Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| two cases of angioimmunoblastic t-cell lymphoma with concomitant positive serology for acute epstein-barr virus infection. | 2017 | 29071053 | |
| managing epstein-barr virus and other risk factors in ms-future perspectives. | here, we discuss the rationale and feasibility of treatment directed against the modifiable risk factors in multiple sclerosis. the established environmental risk factors vitamin d insufficiency, cigarette smoke exposure, adolescence overweight, and epstein-barr virus infection are reviewed. already available measures to target these risk factors are discussed. | 2017 | 29068493 |
| is the hygiene hypothesis relevant for the risk of multiple sclerosis? | the hygiene hypothesis, suggesting that low exposure to pathogens early in life can increase the risk for immune-mediated diseases, has been proposed as an explanation for the increase in incidence of allergy and autoimmune diseases in industrialized countries during the last decades. several aspects of the hygiene hypothesis have been related to ms. already in 1966, the risk of ms was suggested to be higher in individuals with high hygienic standard during childhood. further, an episode of infe ... | 2017 | 29068485 |
| the perivascular microenvironment in epstein-barr virus positive primary central nervous system lymphoma: the role of programmed cell death 1 and programmed cell death ligand 1. | it has been shown that high expression of certain immune checkpoint molecules, including those of the programmed death protein 1/programmed death ligand 1 (pd-1/pd-l1) axis, can be utilized to regulate immunosuppression in the microenvironment of malignant neoplasms. for the purpose of clarifying the immune-escape mechanism of primary central nervous system lymphomas (pcnsls), particularly in epstein-barr virus (ebv)-positive cases, markers for pd-1, pd-l1, tumor-associated macrophages (tams), a ... | 2017 | 29067721 |
| iatrogenic solid tumors following immunosuppressive therapy. | immunosuppression induced by chronic medication, such as occurs post-transplantation, may increase a patient's risk of developing solid tumors. these are often rare tumors characterized by odd presentations. this review focuses on commonly encountered iatrogenic, non-hematopoietic solid tumors following immunotherapy and provides a practical approach to their diagnosis. all of the malignancies covered in this review are viral-induced. they include human papillomavirus (hpv)-associated carcinomas ... | 2017 | 29066044 |
| the battle of rna synthesis: virus versus host. | transcription control is the foundation of gene regulation. whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. over the course of evolution and adaptation, viruses have found diverse ways to optimally exploit cellular host processes such as transcription to their own benefit. just as cells are increasingly understood to employ nascent rnas in transcription regulation, recent discoveries are revealing how viruses use n ... | 2017 | 29065472 |
| gammaherpesviral tegument proteins, pml-nuclear bodies and the ubiquitin-proteasome system. | gammaherpesviruses like epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) subvert the ubiquitin proteasome system for their own benefit in order to facilitate viral gene expression and replication. in particular, viral tegument proteins that share sequence homology to the formylglycineamide ribonucleotide amidotransferase (fgarat, or pfas), an enzyme in the cellular purine biosynthesis, are important for disrupting the intrinsic antiviral response associated with promye ... | 2017 | 29065450 |
| epstein-barr virus infection and oral squamous cell carcinoma risk: a meta-analysis. | the evidence for association between epstein-barr virus (ebv) infection and risk of oral squamous cell carcinoma (oscc) is inconsistent in the literature. therefore, this meta-analysis was conducted to clarify this association. | 2017 | 29065191 |
| evaluation of pd1/pdl1 expression and their clinicopathologic association in ebv-associated lymphoproliferative disorders in nonimmunosuppressed patients. | epstein-barr virus (ebv)-associated lymphoproliferative disorders (lpd)/lymphomas in nonimmunosuppressed patients represent a unique entity and have been proposed to be related to immune senescence. engagement of programmed cell death 1 (pd1) by its ligand programmed death ligand 1 (pdl1) inhibits t-cell activation, and leads to t-cell exhaustion. in clinical trials, therapeutic antibodies that block the pd1-pdl1 axis have shown promising therapeutic activity in certain types of lymphomas. altho ... | 2017 | 29084057 |
| [advances on epstein-barr virus related post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation]. | 2017 | 29081206 | |
| [clinical features of mononucleosis because of epstein-barr virus and cytomegalovirus co-infection in adult patients]. | objective: to identify the clinical features of mononucleosis caused by co-infection of epstein-barr virus (ebv) and cytomegalovirus (cmv) in adult patients. methods: a total of 103 inpatients with mononucleosis in peking university third hospital from may 2013 to may 2016 were collected as the study subjects.the patients were divided into three groups according to the responsible pathogens: 33 patients infected with ebv and cmv, 53 infected with ebv alone and 17 infected with cmv alone.furtherm ... | 2017 | 29081150 |
| cytokines associated with burkitt's lymphoma in western kenya. | burkitt's lymphoma (bl) is a common aggressive non-hodgkin's lymphoma in east and central africa among children. persistent infections with epstein barr virus or plasmodium falciparum are associated with immune hyperstimulation. it is hypothesised that inadvertent cytokine responses to infections indirectly or directly influence b cell neoplastic transformation through c-myelocytomatosis (c-myc) gene translocation. we sought to describe cytokines in children and adolescents with bl. participants ... | 2017 | 29078819 |
| is epstein-barr virus infection associated with the pathogenesis of microscopic colitis? | epstein-barr virus (ebv) has been associated with inflammation in the colon, particularly in patients with inflammatory bowel disease (ibd). even if a relevant plasmocytosis, similar to ibd, is present in microscopic colitis (mc), the frequency of ebv infection in this setting is unknown. | 2017 | 29078077 |
| 18f-fdg pet for detection of primary tracheobronchial t-/natural killer-cell-derived posttransplant lymphoproliferative disorder after lung transplantation. | posttransplant lymphoproliferative disorder (ptld) is a rare, but potentially devastating complication of solid organ transplantation. epstein-barr virus-associated ptlds of t-cell origin are exceedingly rare. we present the case of a 20-year-old man with extranasal t-/natural killer-cell-derived ptld after lung transplantation who underwent an f-fdg pet/ct scan for staging of disease. the f-fdg-pet scan demonstrated an unusual pattern of lymphomatous involvement limited to the recipients trache ... | 2017 | 29076909 |
| multiple oncogenic viruses are present in human breast tissues before development of virus associated breast cancer. | multiple oncogenic viruses including, mouse mammary tumor virus, bovine leukemia virus, human papilloma virus, and epstein barr virus, have been identified as separate infectious pathogens in human breast cancer. here we demonstrate that these four viruses may be present in normal and benign breast tissues 1 to 11 years before the development of same virus breast cancer in the same patients. | 2017 | 29075317 |
| serology of viral infections and tuberculosis screening in an ibd population referred to a tertiary centre of southern italy. | with the introduction of more potent immunosuppressive agents in inflammatory bowel disease, prevention of opportunistic infections has become necessary by introducing screening programs. prevalence of the most important infectious agents may vary in different geographical areas. the aim of our study was to assess the immune status for hepatitis b, varicella, mononucleosis, and cytomegalovirus infection together with the determination of the hepatitis c and tuberculosis status in southern italy. | 2017 | 29075289 |
| protective effect of rituximab in chronic graft-versus-host disease occurrence in allogeneic transplant patients with epstein barr virus viremia. | b cells are involved in chronic graft-versus-host disease (cgvhd) pathogenesis, and rituximab may have a therapeutic effect on cgvhd in allogeneic hematopoietic stem cell transplantation (allo-hsct) patients. herein, we retrospectively evaluated the prophylactic effect of rituximab on cgvhd in a group of chinese allo-hsct patients. a total of 102 patients, who suffered epstein barr virus (ebv) viremia within 100 days after allo-hsct, were included in this study. fifty patients received rituximab ... | 2017 | 29075063 |
| ebv latent membrane protein 2a orchestrates p27kip1 degradation via cks1 to accelerate myc-driven lymphoma in mice. | epstein-barr virus (ebv) establishes lifelong infection in b lymphocytes of most human hosts and is associated with several b lymphomas. during latent infection, ebv encodes latent membrane protein 2a (lmp2a) to promote the survival of b cells by mimicking host b-cell receptor signaling. by studying the roles of lmp2a during lymphoma development in vivo, we found that lmp2a mediates rapid myc-driven lymphoma onset by allowing b cells to bypass myc-induced apoptosis mediated by the p53 pathway in ... | 2017 | 29074502 |
| intratumoural pd-l1 expression is associated with worse survival of patients with epstein-barr virus-associated gastric cancer. | this study investigated the clinical relevance and prognostic impact of the overall expression of programmed cell death protein ligand-1 (pd-l1) and programmed cell death protein ligand-2 (pd-l2), in patients with epstein-barr virus-associated gastric cancer (ebvagc). | 2017 | 29073638 |
| the epstein-barr virus b-zip protein zta recognizes specific dna sequences containing 5-methylcytosine and 5-hydroxymethylcytosine. | the epstein-barr virus (ebv) b-zip transcription factor zta binds to many dna sequences containing methylated cg dinucleotides. using protein binding microarrays (pbms), we analyzed the sequence specific dna binding of zta to four kinds of double-stranded dna (dsdna): (1) dna containing cytosine in both strands, (2) dna with 5-methylcytosine (5mc) in one strand and cytosine in the second strand, (3) dna with 5-hydroxymethylcytosine (5hmc) in one strand and cytosine in the second strand, and (4) ... | 2017 | 29072898 |
| characterization of an anti-fetal achr monoclonal antibody isolated from a myasthenia gravis patient. | we report here the sequence and functional characterization of a recombinantly expressed autoantibody (mab 131) previously isolated from a myasthenia gravis patient by immortalization of thymic b cells using epstein-barr virus and tlr9 activation. the antibody is characterized by a high degree of somatic mutations as well as a 6 amino acid insertion within the vhcdr2. the recombinant mab 131 is specific for the γ-subunit of the fetal achr to which it bound with sub-nanomolar apparent affinity, a ... | 2017 | 29089519 |
| actionable gene-based classification toward precision medicine in gastric cancer. | intertumoral heterogeneity represents a significant hurdle to identifying optimized targeted therapies in gastric cancer (gc). to realize precision medicine for gc patients, an actionable gene alteration-based molecular classification that directly associates gcs with targeted therapies is needed. | 2017 | 29089060 |
| the conundrum of the epstein-barr virus-associated gastric carcinoma in the americas. | epstein-barr virus-associated gastric carcinoma shows a higher prevalence in the americas than asia. we summarize all studies of epstein barr virus-associated gastric carcinoma in the americas, focusing on host characteristics, environmental associations and phylogeographic diversity of epstein-barr virus strains. in the americas, the prevalence of epstein barr virus-associated gastric carcinoma is 11.4%, more frequent in males and portray predominantly diffuse-type histology. ebers, ebnas, bart ... | 2017 | 29088902 |
| irak4 is essential for tlr9-induced suppression of epstein-barr virus bzlf1 transcription in akata burkitt's lymphoma cells. | burkitt's lymphoma (bl) is the most common childhood cancer in equatorial africa, and is endemic to areas where people are chronically co-infected with epstein-barr virus (ebv) and the malaria pathogen plasmodium falciparum. the contribution of these pathogens in the oncogenic process remains poorly understood. we showed earlier that the activation of toll-like receptor (tlr) 9 by hemozoin, a disposal product formed from the digestion of blood by p. falciparum, suppresses the lytic reactivation ... | 2017 | 29088270 |
| adenovirus-associated acute appendicitis: an under-recognized relationship? | acute appendicitis (aa) is one of the most common causes of a surgical abdomen worldwide, occurring most frequently in those age 10 to 29 years. adenovirus (adv) is a rare but reported cause of aa in children and a well-recognized cause of intussusception in infants and young children. annually, about 36,000 basic military trainees (bmts) undergo initial training at joint base san antonio lackland, texas. before reintroduction of the adv 4/7 vaccine in november 2011, one-third of bmts developed ... | 2017 | 29087922 |
| epstein-barr virus brlf1 induces genomic instability and progressive malignancy in nasopharyngeal carcinoma cells. | nasopharyngeal carcinoma (npc) is a serious health problem in china and southeast asia. relapse is the major cause of mortality, but mechanisms of relapse are mysterious. epstein-barr virus (ebv) reactivation and host genomic instability (gi) have correlated with npc development. previously, we reported that lytic early genes dnase and balf3 induce genetic alterations and progressive malignancy in npc cells, implying lytic proteins may be required for npc relapse. in this study, we show that imm ... | 2017 | 29108278 |
| lymphoproliferative disorders with concurrent hhv8 and ebv infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder. | lymphoproliferative disorders (lpd) characterised by human herpesvirus 8 (hhv8) and epstein-barr virus (ebv) infection are rare and two entities are included in the world health organisation classification: primary effusion lymphoma (pel) and germinotropic lpd. these two entities have very different clinicopathological presentations and prognosis. here we describe two cases of hhv8-positive, ebv-positive lymphoma with clinicopathological features that are not consistent with either pel or germin ... | 2017 | 29105119 |
| pathogenic role of exosomes in epstein-barr virus (ebv)-associated cancers. | exosomes are 40- to 100-nm membrane-bound small vesicles that carry a great variety of cellular cargoes including proteins, dna, messenger rnas (mrnas), and micrornas (mirnas). these nanovesicles are detected in various biological fluids such as serum, urine, saliva, and seminal fluids. exosomes serve as key mediators in intercellular communication by facilitating the transfer and exchange of cellular components from cells to cells. they contain various pathogenic factors whereby their adverse e ... | 2017 | 29104494 |
| association between epstein barr virus and tongue squamous cell carcinoma in iranian patients. | detection of epstein-barr virus in oral squamous cell carcinoma suggests its involvement in the carcinogenesis of oral cavity. but, there are few studies on the incidence of ebv genome in squamous cell carcinomas at specific locations in the oral cavity like tongue and with different tumor progression. in this study the presence of ebv genome in tongue squamous cell carcinoma (tscc) in iranian patients were investigated. accordingly, a total of 94 cases with tscc were firstly analyzed for the pr ... | 2017 | 29103768 |
| single nucleotide polymorphism rs2274084 of gap junction protein beta 2 gene among epstein-barr virus-associated tumors. | gap junction protein beta 2 gene (gjb2) encodes one of connexins- connexin 26 (cx26), which mainly expressed in epithelial cells. cx26 is usually considered a channel to exchange information between cells, which plays a critical role in tumor cell proliferation. | 2017 | 29103018 |
| a rare localised nasal cd30+ primary cutaneous t-cell lymphoma following liver transplantation. | cutaneous t-cell post-transplant lymphoproliferative disorder (ptld) is a rare clinical presentation that can potentially turn aggressive in solid-organ transplant recipients if not detected and intervened on early. we encountered a rare case of rapidly worsening primary cutaneous cd30-positive, epstein-barr virus-negative anaplastic large cell lymphoma (alcl) of t-cell origin, manifesting as an isolated nasal tip lesion in a 71-year-old man 4 years after orthotopic liver transplantation. excisi ... | 2017 | 29103006 |
| early disseminated lyme disease masquerading as mononucleosis: a case report. | disseminated lyme disease can be difficult to diagnose, as it begins with nonspecific signs and symptoms, which, if not treated correctly, can lead to atrioventricular conduction blocks and meningitis. in addition, the diagnosis can be further complicated by potentially false-positive test results. | 2017 | 29102094 |
| how immunologic and genetic biomarkers impact hodgkin lymphoma classification, diagnosis, and management: a huge potential that yet needs to be exploited. | "ne è passata di acqua sotto i ponti." it has been a long time since the diagnosis of hodgkin lymphoma (hl) was exclusively based on the detection of typical reed-sternberg cells and the recognition of the characteristic morpho-histological background, as well as on the pathologist's skill. the discovery of immunologic, molecular genetic and virologic biomarkers has provided an objective contribution to the diagnosis and a scientific basis for a modern classification of hl. recent updates have c ... | 2017 | 29099538 |
| hodgkin's lymphoma arising in a case of mycosis fungoides: an unusual association. | mycosis fungoides is a cutaneous t-cell lymphoma with a high risk for developing secondary malignancies, especially b-cell lymphoproliferative disorders. about 40 cases of hodgkin's lymphoma associated with mycosis fungoides have been reported in literature till date. we report a case of a 35-year-old gentleman who presented with intensely itchy reddish lesions all over the body. multiple skin biopsies taken from the lesions on scalp and back confirmed the clinical diagnosis of mycosis fungoides ... | 2017 | 29098990 |
| epstein-barr virus dna load kinetics analysis in allogeneic hematopoietic stem cell transplant recipients: is it of any clinical usefulness? | there is a lack of clinical information regarding the usefulness of plasma epstein-barr virus (ebv) dna load kinetics analyses in the management of ebv infections in allogeneic hematopoietic stem cell transplantation (allo-hsct) recipients. namely, it remains unknown whether this type of analysis can help physicians to anticipate the development of high-level ebv dnaemia episodes requiring rituximab treatment or predict the risk of recurrent ebv dnaemia or post-transplant lymphoproliferative dis ... | 2017 | 29096390 |
| age-related macular degeneration: a connection between human herpes virus-6a-induced cd46 downregulation and complement activation? | viruses are able to interfere with the immune system by docking to receptors on host cells that are important for proper functioning of the immune system. a well-known example is the human immunodeficiency virus that uses cd4 cell surface molecules to enter host lymphocytes and thereby deleteriously destroying the helper cell population of the immune system. a more complicated mechanism is seen in multiple sclerosis (ms) where human herpes virus-6a (hhv-6a) infects astrocytes by docking to the c ... | 2017 | 29093709 |
| nasopharyngeal carcinoma risk prediction via salivary detection of host and epstein-barr virus genetic variants. | genetic susceptibility and epstein-barr virus (ebv) infection are important etiological factors in nasopharyngeal carcinoma (npc). in this study, in southern china, where npc is endemic, a single nucleotide polymorphism (snp) in the ebv-encoded rpms1 gene (locus 155391: g > a [g155391a]) and seven host snps (rs1412829, rs28421666, rs2860580, rs2894207, rs31489, rs6774494, and rs9510787) were confirmed to be significantly associated with npc risk in 50 npc cases versus 54 hospital-based controls ... | 2017 | 29221111 |
| low levels of antibodies against common viruses associate with anti-citrullinated protein antibody-positive rheumatoid arthritis; implications for disease aetiology. | infection by common viruses has long been discussed in the aetiology of a number of autoimmune diseases, including rheumatoid arthritis (ra). however, studies investigating this hypothesis in ra show conflicting results. these studies often lack well-matched control populations, and many do not include data on autoantibodies, genetic risk factors and other environmental factors, which are known to contribute to disease only in subgroups of patients. in the present study, we have therefore examin ... | 2017 | 28962582 |
| safety and efficacy of biologic agents for the management of inflammatory bowel disease after liver transplantation. | primary sclerosing cholangitis (psc) frequently progresses to end-stage liver disease and cirrhosis, requiring liver transplantation. approximately 70% of patients with psc have concomitant inflammatory bowel disease (ibd) during their clinical course. after liver transplantation for psc, corticosteroids and other high-intensity immunosuppressants are initiated to keep ibd in remission. patients with ibd that is refractory to these agents may need to be managed with biologic therapies. biologic ... | 2017 | 28960437 |
| il-27-induced type 1 regulatory t-cells produce oxysterols that constrain il-10 production. | the behaviors of lymphocytes, including cd4+ t helper cells, are controlled on many levels by internal metabolic properties. lipid metabolites have recently been ascribed a novel function as immune response modulators and perturbation of steroids pathways modulates inflammation and potentially promotes a variety of diseases. however, the impact of lipid metabolism on autoimmune disease development and lymphocyte biology is still largely unraveled. in this line, oxysterols, oxidized forms of chol ... | 2017 | 28993775 |
| a distinctive subgroup of oral ebv+ b-cell neoplasm with polymorphous features is potentially identical to ebv+ mucocutaneous ulcer. | epstein-barr virus-positive mucocutaneous ulcer (ebvmcu) is a newly recognized provisional entity included in mature b-cell neoplasm in the latest 2016 world health organization classification. it has a self-limited growth potential with a high predilection for oral cavities and occurs in age-related or iatrogenic immunodeficiency with indolent clinical courses. however, it shares histological features with ebv-positive diffuse large b-cell lymphoma (dlbcl), and this often leads to diagnostic ch ... | 2017 | 28993276 |
| [the epstein-barr virus and the centriole: new tricks from an old dog]. | 2017 | 28990548 | |
| epstein-barr virus fusion with epithelial cells triggered by gb is restricted by a gl glycosylation site. | epstein-barr virus (ebv) entry into epithelial cells is mediated by the conserved core fusion machinery, composed of the fusogen gb and the receptor-binding complex gh/gl. the heterodimeric gh/gl complex binds to the ebv epithelial cell receptor or gp42, which binds to the b-cell receptor, triggering gb-mediated fusion of the virion envelope with cellular membranes. our previous study found that the gl glycosylation mutant n69l/s71v had an epithelial cell-specific hyperfusogenic phenotype. to st ... | 2017 | 28956769 |
| epstein-barr virus-associated haemophagocytic lymphohistiocytosis presenting with acute sensorineural hearing loss: a case report and review of the literature. | epstein-barr virus-associated haemophagocytic lymphohistiocytosis (ebv-hlh) is a life-threatening catastrophic and rarely seen complication of ebv infection especially in adults. while typical presentation of ebv infection is easily diagnosed as mononucleosis syndrome in teenagers and adults, some atypical clinical presentations may be challenged. we did not encounter any patient presenting with sudden sensorineural hearing loss associated with ebv infection in our english medical literature res ... | 2017 | 28956548 |
| [clinical analysis of 7 patients with epstein-barr virus encephalitis after allogeneic hematopoietic stem cell transplantation]. | objective: to summarize the clinical features, treatment and prognosis of patients with epstein barr virus (ebv) encephalitis after allogeneic hematopoietic stem cell transplantation (allo-hsct) . methods: the clinical data of 7 patients with ebv encephalitis who had undergone allo-hsct in the first affiliated hospital of soochow university from january 2012 to december 2015 were reviewed. results: the incidence of ebv encephalitis was 0.70% (7/998) , and the median time was 63 (10-136) d after ... | 2017 | 28954347 |
| depressive symptoms are associated with salivary shedding of epstein-barr virus in female adolescents: the role of sex differences. | adolescent females have a higher prevalence of depression in comparison to their male peers - a disparity that has been increasing over the past decade. depression is of concern as it is associated with chronic disease and to immune dysregulation, which may be one mechanism linking depression to future pathology. this study examined the extent to which sex moderated the association between depressive symptoms and immune dysregulation during adolescence using epstein-barr virus (ebv) reactivation ... | 2017 | 28954244 |
| resveratrol inhibits extranodal nk/t cell lymphoma through activation of dna damage response pathway. | extranodal nk/t cell lymphoma (nktcl) is a highly aggressive non-hodgkin lymphoma with poor prognosis. resveratrol (rsv, 3,5,4'-trihydroxystilbene), a natural nontoxic phenolic compound found in the skin of grapes and some other spermatophytes, performs multiple bioactivities, such as antioxidant activity, anti-aging activity, reduction of cardiovascular disease risk and anticarcinogenic effect. here we report the anti-tumor effect of rsv in nktcl cell lines snt-8, snk-10 and snt-16. | 2017 | 28950914 |
| the epstein-barr virus mir-bhrf1 micrornas regulate viral gene expression in cis. | the epstein-barr virus (ebv) mir-bhrf1 microrna (mirna) cluster has been shown to facilitate b-cell transformation and promote the rapid growth of the resultant lymphoblastoid cell lines (lcls). however, we find that expression of physiological levels of the mir-bhrf1 mirnas in lcls transformed with a mir-bhrf1 null mutant (∆123) fails to increase their growth rate. we demonstrate that the pri-mir-bhrf1-2 and 1-3 stem-loops are present in the 3'utr of transcripts encoding ebna-lp and that excisi ... | 2017 | 28950226 |
| lytic ebv infection investigated by detection of soluble epstein-barr virus zebra in the serum of patients with ptld. | the zebra protein (encoded by the bzlf1 gene), is the major transcription factor of ebv, expressed upon ebv lytic cycle activation. several studies highlighted the critical role of ebv lytic infection as a risk factor for lymphoproliferative disorders like post-transplant lymphoproliferative disease (ptld). here, we use an antigen-capture elisa assay specifically designed to detecting the circulating soluble zebra (szebra) in serum samples (threshold value determined at 40ng/ml). we retrospectiv ... | 2017 | 28874674 |
| extranodal nasal-type natural killer/t-cell lymphoma with penile involvement: a case report and review of the literature. | extranodal natural killer/t-cell lymphoma (enktl) usually presents as a localized disease in the nasal cavity; extension to the male genitourinary system is very rare and has been characterized only recently. most cases present with predominantly extranodal involvement, advanced stage disease, highly aggressive course, and strong association with epstein-barr virus (ebv). while metastasis is common in enktls, the penis is rarely involved in both nasal and non-nasal enktls and only one report was ... | 2017 | 28874193 |
| primary cutaneous nk/t-cell lymphoma of nasal type: an age-related lymphoproliferative disease? | among extranodal nk/t-cell lymphoma of nasal type (nktl), the extranasal variant (enktl) is known to have a worse prognosis with advanced clinical stage than the nasal variant of nktl. however, detailed clinicopathological features of the localized extranasal disease have not been well documented in english literature. here, we described the clinicopathological profiles of 14 patients with stage i enktl, including 7 in the skin, 5 in the gastrointestinal tract, and 2 in the central nervous syste ... | 2017 | 28873353 |
| transforming growth factor-β, interleukin-10, and serological markers in ebv-associated gastric carcinoma. | the association between epstein-barr virus (ebv) and gastric cancer (gc) has been reported by many researchers. immunosuppressive cytokines, such as interleukin-10 (il-10) and transforming growth factor β (tgfβ), play an important role in the tumor process. the aim of the present study was to detect antibodies against ebv and explore the levels of tgfβ and il-10 in polish gc patients. | 2017 | 28870905 |
| unexplained dyspnea in a young adult with epstein-barr virus infectious mononucleosis: pulmonary involvement or co-infection with mycoplasma pneumoniae pneumonia? | clinically, in young immunocompetent adults, epstein-barr virus (ebv) usually manifests as infectious mononucleosis (im). typical clinical findings of ebv im include fever, profound fatigue, pharyngitis, bilateral posterior cervical adenopathy, and splenomegaly. respiratory involvement with ebv im may occur, but is distinctly rare. we present a case of a 20 year old female who with classic ebv im, but was inexplicably dyspneic and hypoxemic. further diagnostic testing confirmed co-infection with ... | 2017 | 28869530 |
| epstein-barr virus infection in children with renal transplantation: a single-center experience. | this study aimed to investigate the incidence, timing, manifestations, managements, and outcomes of epstein-barr virus (ebv) infection in pediatric renal transplant recipients in korea. | 2017 | 28869325 |
| massive splenomegaly due to concurrent primary epstein-barr virus and cytomegalovirus infection in a patient on adalimumab. | a 32-year-old man who was receiving adalimumab for seronegative rheumatoid arthritis presented with a 4-week history of fever, night sweats, fatigue, myalgias and diarrhoea. on examination, he had obvious splenomegaly but no lymphadenopathy or pharyngitis. full blood count revealed mild neutropenia and significant lymphocytosis, with a blood film showing atypical lymphocytes. liver function tests were mildly deranged with a mixed hepatitic and obstructive pattern. ultrasound confirmed massive sp ... | 2017 | 28864556 |
| beating 'guangdong cancer': a review and update on nasopharyngeal cancer. | once endemic in southern china, nasopharyngeal cancer is becoming less prevalent in hong kong. this is probably due to a better understanding of the risk factors associated with the disease, its genomic landscape, advances in radiotherapy technology, and development of effective systemic agents. more specifically, the close relationship between epstein-barr virus and nasopharyngeal cancer opens up the possibility of using epstein-barr virus dna as a biomarker for early detection and monitoring o ... | 2017 | 28862144 |
| epstein-barr virus-encoded small rnas in idiopathic orbital inflammatory pseudotumor tissues: a comparative case series. | to investigate the positive rate and types of cells that express epstein-barr virus-encoded small rnas (ebers) and to determine the distribution of eber-expressing cells in idiopathic orbital inflammatory pseudotumor (ioip) tissues. | 2017 | 28861354 |
| infectious mononucleosis-like syndrome with high lymphocytosis and positive igm ebv and cmv antibodies in a three-year-old girl. | primary epstein-barr virus (ebv) and cytomegalovirus (cmv) infection usually affects preadolescent children or young adults, causing similar clinical presentation. signs and symptoms are typically mild, and the majority of clinical and laboratory findings resolve spontaneously within one month after onset. in adulthood, the risk of fulminant ebv infection and severe complications is much higher, which may be related to increasing memory cd8+ t-cell population with age. it is still not clear what ... | 2017 | 28860939 |
| interleukin-6-dependent growth in a newly established plasmablastic lymphoma cell line and its therapeutic targets. | plasmablastic lymphoma (pbl) is a rare, highly aggressive subtype of non-hodgkin lymphoma with plasma-cell differentiation occurring typically in immune-suppressed patients such as those with aids. this study reports the establishment and characterization of a new cell line, pbl-1, derived from a patient with aids-associated pbl. morphological assessment of pbl-1 indicated plasma-cell differentiation with a cd20(-) cd38(+) cd138(+) immunophenotype and igh/c-myc translocation. the cell line harbo ... | 2017 | 28860565 |
| the major histocompatibility complex class i immunopeptidome of extracellular vesicles. | extracellular vesicles (evs) are released by most cell types and have been associated with multiple immunomodulatory functions. mhc class i molecules have crucial roles in antigen presentation and in eliciting immune responses and are known to be incorporated into evs. however, the mhc class i immunopeptidome of evs has not been established. here, using a small-scale immunoisolation of the antigen serotypes hla-a*02:01 and hla-b*27:05 expressed on the epstein-barr virus-transformed b cell line j ... | 2017 | 28860189 |
| epstein-barr virus-encoded latent membrane protein 1 induces epithelial to mesenchymal transition by inducing v-set ig domain containing 4 (vsig4) expression via nf-kb in renal tubular epithelial hk-2 cells. | the epithelial to mesenchymal transition (emt), a hallmark of chronic kidney disease, is a key event in the conversion from tubular epithelial cells to myofibroblasts in renal fibrosis. epstein-barr virus (ebv) is a γ-herpes oncovirus associated with chronic kidney disease. however, the relationship between ebv and the emt process in renal tubular epithelial cells is not well understood. among ebv-latent genes, ebv-encoded latent membrane protein 1 (lmp1) induces emt by regulating a variety of m ... | 2017 | 28859984 |
| a gain-of-function mutation in tnfrsf13b is a candidate for predisposition to familial or sporadic immune thrombocytopenia. | essentials positive family histories suggest the existence of hereditary immune thrombocytopenia (itp). the predisposing gene for familial itp was screened in two familial itp patients. the g76s mutation on tnfrsf13b led to immune dysfunction and induced megakaryocyte apoptosis. the g76s mutation on tnfrsf13b is a gain-of-function mutation and a predisposing variant for itp. | 2017 | 28834165 |
| cutaneous intravascular natural killer/t cell lymphoma with peculiar immunophenotype. | intravascular lymphoma (ivl) is a rare entity. most cases are a variant of extranodal diffuse large b cell lymphoma, and fewer than 10% of the published cases are of t cell origin. only intravascular b cell lymphoma is recognized as a distinct entity in the most recent world health organization (who) classification of lymphoproliferative disorders. we describe a case of cutaneous natural killer (nk)/t ivl, with a cytotoxic immunophenotype and epstein-barr virus (ebv) positivity. however, our cas ... | 2017 | 28766736 |
| ebv-hlh children with reductions in cd4+ t cells and excessive activation of cd8+ t cells. | backgroundin this report, we analyzed the number and activation profiles of t cells in epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh) patients and assessed their value for the diagnosis of ebv-hlh.methodswe compared the quantity of cd4+ t cells and cd8+ t cells in peripheral blood among hlh patients, a sepsis group, and healthy controls. we then analyzed variations in the activation marker in cd4+ t and cd8+ t cells.resultsthe percentage of cd4+ t cells decreased in t ... | 2017 | 28738028 |
| selective expression of ccr10 and cxcr3 by circulating human herpes simplex virus-specific cd8 t cells. | herpes simplex virus (hsv) infection is restricted to epithelial cells and neurons and is controlled by cd8 t cells. these cells both traffic to epithelial sites of recurrent lytic infection and to ganglia and persist at the dermal-epidermal junction for up to 12 weeks after lesion resolution. we previously showed that cutaneous lymphocyte-associated antigen (cla), a functional e-selectin ligand (esl), is selectively expressed on circulating hsv-2-specific cd8 t cells. cla/esl mediates adhesion ... | 2017 | 28701399 |
| triterpenoids from ganoderma lucidum inhibit the activation of ebv antigens as telomerase inhibitors. | nasopharyngeal carcinoma (npc) is a malignant disease that threatens the health of humans. to find effective agents for the inhibition of epstein-barr virus (ebv) infection, which is associated with npc, a phytochemical investigation of ganoderma lucidum was carried out in the present study. five triterpenoids were identified, including ganoderic acid a (compound 1), ganoderic acid b (compound 2), ganoderol b (compound 3), ganodermanontriol (compound 4), and ganodermanondiol (compound 5), on the ... | 2017 | 28912878 |
| epstein-barr virus and cytomegalovirus induced acute hepatitis in young female patient. | acute hepatitis is a disorder that goes with liver cell necrosis and liver inflammation. among the causes of acute hepatitis, the most common reasons are viral hepatitis. about 95% of the acute hepatitis generate because of hepatotropic viruses. epstein-barr virus (ebv) and cytomegalovirus (cmv) are from the family of herpes viruses and rare causes of acute hepatitis. in this case report, acute hepatitis due to ebv and cmv coinfection will be described. | 2017 | 29201691 |
| role of infectious agents in cutaneous t-cell lymphoma: facts and controversies. | the etiology of cutaneous t-cell lymphoma (ctcl) remains unknown, with potential infectious causes having been explored. this contribution evaluates the evidence suggesting an infectious etiology and pathogenesis of the disease, characterizes the relationships between various specific pathogens and ctcl, and discusses some of the difficulties in establishing a causal link between infectious agents and ctcl carcinogenesis. researchers have evaluated ctcl specimens for evidence of infection with a ... | 2017 | 23806159 |
| the histological and biological spectrum of diffuse large b-cell lymphoma in the world health organization classification. | diffuse large b-cell lymphomas (dlbcls) are aggressive b-cell lymphomas that are clinically, pathologically, and genetically diverse, in part reflecting the functional diversity of the b-cell system. the focus in recent years has been toward incorporation of clinical features, morphology, immunohistochemistry, and ever evolving genetic data into the classification scheme. the 2008 world health organization classification reflects this complexity with the addition of several new entities and vari ... | 2017 | 23006945 |
| t-cell lymphoma/sézary syndrome in a liver transplant recipient. | cutaneous t-cell lymphoma is a rare subtype of posttransplantation lymphoproliferative disease, with only 29 cases reported in the literature to date, the majority of which are post-renal transplantation. only a few were reported after pancreas, heart, and bone marrow transplantation. there have been no reports of cutaneous t-cell lymphoma following liver transplantation to date. | 2017 | 22418000 |
| effects of epstein-barr virus on the development of dendritic cells derived from cord blood monocytes: an essential role for apoptosis. | epstein-barr virus (ebv) is a ubiquitous human γ-herpes virus, which can adapt and evade host immune defense. dendritic cells (dcs) play a pivotal role in the initiation and maintenance of immune responses. this study investigated the effects of ebv on cord blood monocytes derived dcs (cbdc). | 2017 | 22358351 |
| use of plasma epstein-barr virus dna monitoring as a tumor marker in follow-up of patients with nasopharyngeal carcinoma: preliminary results and report of two cases. | recent studies suggest that plasma epstein-barr virus (ebv) dna may reflect tumor burden in patients with nasopharyngeal cancer. a prospective study was initiated to investigate this correlation in 125 patients (34 pretreatment [group a], 78 in remission [group b] and 13 relapsed [group c]) and 19 healthy controls. in group a, ebv dna was detected in plasma samples of 24 (70%) patients. in group b, ebv dna was detected in 7 patients (range 77-13,731 copies/ml) and further imaging in all but one ... | 2017 | 28207133 |
| epstein-barr positive t-cell lymphoma in the ocular region. | to present two cases of rapidly growing tumors in the ocular adnexa. both tumors were epstein-barr virus (ebv) positive peripheral t-cell lymphoma. | 2017 | 28221481 |
| a new case of acute idiopathic frosted branch angiitis in europe. | a 20-year-old male with no history of any systemic or eye disease developed loss of visual acuity in both eyes. white exudates surrounding the retinal veins from the posterior pole to the periphery, retinal edema and hemorrhages in both eyes were evident on ophthalmoscopy. fluorescein angiography showed leakage of the dye from the veins and extensive staining of the vein walls. a diagnosis of acute frosted branch angiitis was made. systemic examination revealed axillary, submandibular and inguin ... | 2017 | 28226129 |
| characterization and serotype distribution of aggregatibacter actinomycetemcomitans: relationship of serotypes to herpesvirus and periodontal status in indian subjects. | the virulence of aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) in any individual depends on the type of strain of this bacterium. to our knowledge, there have been no studies reported in indian subjects about a. actinomycetemcomitans serotype occurrence, co-existence with herpes virus and the possible influence of such co-existence on periodontal pathology. | 2017 | 28668607 |
| [bilateral facial nerve palsy associated with epstein-barr virus infection in a 3-year-old boy]. | bilateral facial nerve palsy is a rare and sometimes difficult diagnosis. we describe a case of bilateral simultaneous facial nerve palsy associated with epstein-barr virus (ebv) infection in a 3-year-old boy. several symptoms led to the diagnosis of ebv infection: the clinical situation (fever, stomachache, and throat infection), white blood cell count (5300/mm(3) with 70% lymphocyte count), seroconversion with ebv-specific antibodies, lymphocytic meningitis, and a positive blood ebv polymerase ... | 2017 | 28416425 |
| evaluation of a taqman array card for detection of central nervous system infections. | infections of the central nervous system (cns) are often acute, with significant morbidity and mortality. routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-saharan africa. we developed a taqman array card (tac) that detects multiple pathogens simultaneously from cerebrospinal fluid. the 21-pathogen cns multiple-pathogen tac (cns-tac) assay includes two parasites (ba ... | 2017 | 28404679 |
| unrelated umbilical cord blood transplantation for sickle cell disease following reduced-intensity conditioning: results of a phase i trial. | hematopoietic stem cell transplantation from hla-matched sibling donors results in disease-free survival of >90% in patients with sickle cell disease (scd); however, only approximately 18% of these patients have suitable donors available. unrelated cord blood transplantation (ucbt) is one way to expand donor options for patients with severe scd, but historically has been associated with high graft rejection rates (50% to 62%). we hypothesized that the addition of thiotepa to a previously tested ... | 2017 | 28578010 |
| mumps clinical diagnostic uncertainty. | during recent years, various mumps outbreaks have occurred among populations vaccinated for mumps worldwide. in italy, improving routine coverage with two doses of measles, mumps and rubella (mmr) vaccine is one of the key strategies to eliminate measles and rubella. to monitor the effect of the vaccination programme on the population, the surveillance of these vaccine-preventable diseases has been implemented. this provided the opportunity to evaluate the accuracy of the clinical diagnosis of t ... | 2017 | 28633302 |
| a b cell-driven autoimmune pathway leading to pathological hallmarks of progressive multiple sclerosis in the marmoset experimental autoimmune encephalomyelitis model. | the absence of pathological hallmarks of progressive multiple sclerosis (ms) in commonly used rodent models of experimental autoimmune encephalomyelitis (eae) hinders the development of adequate treatments for progressive disease. work reviewed here shows that such hallmarks are present in the eae model in marmoset monkeys (callithrix jacchus). the minimal requirement for induction of progressive ms pathology is immunization with a synthetic peptide representing residues 34-56 from human myelin ... | 2017 | 28744286 |
| mountain gorilla lymphocryptovirus has epstein-barr virus-like epidemiology and pathology in infants. | epstein-barr virus (ebv) infects greater than 90% of humans, is recognized as a significant comorbidity with hiv/aids, and is an etiologic agent for some human cancers. the critically endangered mountain gorilla population was suspected of infection with an ebv-like virus based on serology and infant histopathology similar to pulmonary reactive lymphoid hyperplasia (prlh), a condition associated with ebv in hiv-infected children. to further examine the presence of ebv or an ebv-like virus in mou ... | 2017 | 28706209 |
| histone h4k20 tri-methylation at late-firing origins ensures timely heterochromatin replication. | among other targets, the protein lysine methyltransferase pr-set7 induces histone h4 lysine 20 monomethylation (h4k20me1), which is the substrate for further methylation by the suv4-20h methyltransferase. although these enzymes have been implicated in control of replication origins, the specific contribution of h4k20 methylation to dna replication remains unclear. here, we show that h4k20 mutation in mammalian cells, unlike in drosophila, partially impairs s-phase progression and protects from d ... | 2017 | 28778956 |
| risk of superinfection in peri-implantitis after systemic broad spectrum antibiotics. | peri-implant disease has developed over the last few years as a complication that is often difficult to resolve. the disease process is mainly attributed to bacterial infection. proposed combined therapies use broad-spectrum antibiotics to halt its progression. a major associated risk is the undetected development of superinfections that are difficult to eradicate. a group of healthy individuals with advanced peri-implantitis (pi) were referred for evaluation due to severe, rapidly progressive b ... | 2017 | 28854287 |
| simultaneous pancreas/kidney transplant recipients are predisposed to tissue-invasive cytomegalovirus disease and concomitant infectious complications. | infections have increased in simultaneous pancreas/kidney transplant recipients (spktrs) with cytomegalovirus (cmv) infection being the most important viral infection with adverse impact on patient and allograft outcomes. | 2017 | 28665480 |
| impact of stem cell graft on early viral infections and immune reconstitution after allogeneic transplantation in adults. | viral infections are well-known complications after allogeneic stem cell transplant (allo-sct). | 2017 | 28601677 |
| are the polyomaviruses bk and jc associated with opportunistic infections, graft-versus-host disease, or worse outcomes in adult patients receiving their first allogeneic stem cell transplantation with low-dose alemtuzumab? | the association of polyomaviruses bk and jc with other opportunistic infections and graft-versus-host disease (gvhd) in allogeneic stem cell transplantation is controversially discussed. | 2017 | 28591758 |
| primary central nervous system diffuse large b-cell lymphoma shows an activated b-cell-like phenotype with co-expression of c-myc, bcl-2, and bcl-6. | diffuse large b-cell lymphoma (dlbcl) is the most common non-hodgkin lymphoma, whose main prognostic factor is closely related to germinal center b-cell-like subtype (gcb- dlbcl) or activated b-cell-like type (non-gcb-dlbcl). the most common type of primary central nervous system lymphoma is diffuse large b-cell type with poor prognosis and the reason is unclear. this study aims to stratify primary central nervous system diffuse large b-cell lymphoma (pcns-dlbcl) according to the cell-of-origin ... | 2017 | 28552541 |
| [evaluation of dynamic telomere length shortening of lymphocytes in immunocompromised children with chronic diseases of the respiratory]. | nowadays it is common to observe the growth of viral-viral and viral-bacterial co-infections in children of different ages, due to dysfunction of lymphocytes (dl), which can be connected with the process of the accelerated shortening of the end structures of chromosomal telomeres, telomere length changes are described in lymphocytes of children with chronic mono-infections. the conducted study has shown the shortening of telomere lymphocytes in children with cdrt seropositive for mixed-herpes vi ... | 2017 | 28628024 |
| viral aetiologies of acute encephalitis in a hospital-based south asian population. | the aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. we aimed to identify the viruses that cause infectious encephalitis in sri lanka, which represents a south asian population. | 2017 | 28438128 |
| herpes simplex virus 1 and cytomegalovirus are associated with pemphigus vulgaris but not with pemphigus foliaceus disease. | pemphigus vulgaris (pv) and pemphigus foliaceus (pf) are blistering autoimmune diseases that depend on interaction between genetic and environmental factors. viral infections, like herpes simplex viruses 1 and 2 (hsv1/2), cytomegalovirus (cmv), epstein-barr virus and dengue virus, could trigger or exacerbate pemphigus. igm and igg antibodies against these viruses in serum from pv and pf, their relatives and controls were determined. hsv1/2 expression was evaluated by direct immunofluorescence (d ... | 2017 | 28370424 |
| real-time pcr detection of the most common bacteria and viruses causing meningitis. | central nervous system (cns) infections require prompt diagnosis, as the clinical condition progresses rapidly and may lead to severe permanent sequelae or death. the causative agents include viruses, bacteria, fungi, and parasites. in this study, samples with the diagnosis of cns infection based on cerebrospinal fluid (csf) sent to us from other hospitals/labs, were studied by multiplex real-time polymerase chain reaction (pcr) method. the purpose of this study is to demonstrate, retrospectivel ... | 2017 | 28397477 |
| seasonality and autoimmune diseases: the contribution of the four seasons to the mosaic of autoimmunity. | autoimmune diseases (ads) are a heterogeneous groups of diseases that occur as a results of loss of tolerance to self antigens. while the etiopathogeneis remain obscure, different environmental factors were suggested to have a role in the development of autoimmunity, including infections, low vitamin d levels, uv radiation, and melatonin. interestingly, such factors possess seasonal variation patterns that could influence disease development, severity and progression. vitamin d levels which reac ... | 2017 | 28624334 |
| prevalence and characteristics of epstein-barr virus-associated gastric carcinomas in portugal. | gastric cancer (gc) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. epstein-barr virus (ebv) has been associated with approximately 10% of the total cases of gastric carcinomas. no previous study has analyzed the prevalence of ebv infection in gastric cancer of the portuguese population. | 2017 | 28814970 |
| cytokine expression associated with helicobacter pylori and epstein-barr virus infection in gastric carcinogenesis. | helicobacter pylori and epstein-barr virus (ebv) infection, and associated cytokines are involved in gastric carcinogenesis. we investigated the expression of these cytokines and their relationship with clinicopathological characteristics. the study included specimens from 207 patients with gastric adenocarcinoma, 56 with chronic gastritis, 32 with metaplasia, and 30 with low-grade epithelial dysplasia. tissue microarrays were constructed and immunohistochemical staining for il-1β, il-6, il-10, ... | 2017 | 28736845 |
| cancer incidence attributable to lifestyle and environmental factors in alberta in 2012: summary of results. | estimates of the proportion of cancer cases that can be attributed to modifiable risk factors are not available for canada and, more specifically, alberta. the purpose of this study was to estimate the total proportion of cancer cases in alberta in 2012 that could be attributed to a set of 24 modifiable lifestyle and environmental risk factors. | 2017 | 28687643 |
| aberrant expression of aid and aid activators of nf-κb and pax5 is irrelevant to ebv-associated gastric cancers, but is associated with carcinogenesis in certain ebv-non-associated gastric cancers. | epstein-barr virus-associated gastric carcinoma (ebvagc) is a distinct subtype of gastric cancer characterized by clinicopathological features including lymphoepithelioma-like histology. aberrant expression of activation-induced cytidine deaminase (aid) as a genomic modulator was demonstrated through pathogen-related nuclear factor κb (nf-κb) signaling in helicobacter pylori-associated gastric cancer. to elucidate whether or not aid expression is relevant to carcinogenesis in ebvagc, immunohisto ... | 2017 | 28588701 |
| the gastric microbiome and its influence on gastric carcinogenesis: current knowledge and ongoing research. | gastric malignancies are a leading cause of cancer-related death worldwide. at least 2 microbial species are currently linked to carcinogenesis and the development of cancer within the human stomach. these include the bacterium helicobacter pylori and the epstein-barr virus. in recent years, there has been increasing evidence that within the human gastrointestinal tract it is not only pathogenic microbes that impact human health but also the corresponding autochthonous microbial communities. thi ... | 2017 | 28501083 |
| preanalytical stability of antibodies to pathogenic antigens. | background: serologic testing for antibodies against epitopes from pathogens is a valuable tool for investigating the relationship between infection and disease. this study comprehensively evaluates the impact of preanalytic variation on antibody seropositivities to a selected set of antigens arising from delays in processing of blood samples, preprocessing storage temperature, and vacutainer type.methods: we assessed peripheral blood collected from 29 volunteers in four different vacutainer typ ... | 2017 | 28483968 |
| lymphoepithelioma-like gastric carcinoma: clinicopathological characteristics and infection status. | lymphoepithelioma-like gastric carcinoma (llgc) is a rare subtype of gastric carcinoma (gc) characterized by prominent lymphocytic infiltration. llgc may be associated with latent epstein-barr virus (ebv) infection or microsatellite instability (msi). this study aims to assess the clinicopathological characteristics, ebv infection, and msi status in llgc. | 2017 | 28457323 |
| status of epstein-barr virus coinfection with helicobacter pylori in gastric cancer. | epstein-barr virus is a ubiquitous human herpesvirus whose primary infection causes mononucleosis, burkett's lymphoma, nasopharyngeal carcinoma, autoimmune diseases, and gastric cancer (gc). the persistent infection causes malignancies in lymph and epithelial cells. helicobacter pylori causes gastritis in human with chronic inflammation. this chronic inflammation is thought to be the cause of genomic instability. about 45%-word population have a probability of having both pathogens, namely, h. p ... | 2017 | 28421114 |