Publications

etiology of tick-borne febrile illnesses in adult residents of north-eastern poland: report from a prospective clinical study.	febrile tick-borne diseases can be caused by different pathogens. the study objective was to prospectively determine the etiology of infection among adults exposed to tick bite and to detect acute human granulocytic anaplasmosis (hga), a recently emerging infection, in north-eastern poland. we evaluated 68 patients (34 males and 34 females, mean age 44.2+/-15 years) who had fever within 4 weeks after a tick bite. paired sera were tested for antibodies against tick-borne encephalitis virus, borre ...	2006	16530481
predominant t helper 2 immune responses against bartonella henselae in naturally infected cats.	this study was conducted to explicate the mechanism of long-term bacteremia in bartonella henselae-infected cats by the examining host immune responses. blood samples were collected from three naturally infected cats and the igg antibody titers and the cytokine responses in peripheral blood mononuclear cells (pbmc) were examined by quantitative reverse transcriptase-polymerase chain reactions (rt-pcr). relapsing bacteremia was found in two of the three cats during the examination period. the qua ...	2006	16547414
anti-francisella tularensis dna aptamers detect tularemia antigen from different subspecies by aptamer-linked immobilized sorbent assay.	aptamers are powerful candidates for molecular detection of targets due to their unique recognition properties. these affinity probes can be used to recognize and bind to their targets in the various types of assays that are currently used to detect and capture molecules of interest. they are short single-stranded (ss) oligonucleotides composed of dna or rna sequences that are selected in vitro based on their affinity and specificity for the target. using combinatorial oligonucleotide libraries, ...	2006	16550191
pet ownership in immunocompromised children--a review of the literature and survey of existing guidelines.	pet ownership has been associated with both emotional and physical health benefits. however, owning pets may also pose health risks to immunocompromised patients through zoonotic transmission of disease. our initial impression was that there is a lack of any evidence base in information given by health care professionals regarding these risks. we therefore aimed to produce evidence-based guidelines addressing this issue. a pubmed search was undertaken and a variety of literature on zoonoses revi ...	2006	16581294
co-detection of bartonella henselae, borrelia burgdorferi, and anaplasma phagocytophilum in ixodes pacificus ticks from california, usa.	presence of bartonella dna was explored in 168 questing adult ixodes pacificus ticks from santa cruz county, california. bartonella henselae type i dna was amplified from 11 ticks (6.55%); previously, two (1.19%) were found to be infected with borrelia burgdorferi and five (2.98%) with anaplasma phagocytophilum. detection of b. henselae was not dependent on co-infection. the present study offers additional evidence that ixodes spp. ticks may act as hosts and possibly vectors for b. henselae.	2006	16584332
molecular detection of microbes in nasal tissue of dogs with idiopathic lymphoplasmacytic rhinitis.	lymphoplasmacytic rhinitis (lpr) is a common histologic finding in dogs with chronic nasal disease; however, potential etiologies of this disorder have not been examined. we investigated the hypothesis that specific microbes contribute to clinical disease in dogs with lpr. paraffin-embedded nasal biopsies were obtained from 19 dogs with lpr, 10 dogs with nasal neoplasia, and 10 dogs with nasal aspergillosis. nucleic acids were extracted from paraffin blocks, and real-time quantitative polymerase ...	2006	16594580
rickettsial agents from parasitic dermanyssoidea (acari: mesostigmata).	mites are often overlooked as vectors of pathogens, but have been shown to harbor and transmit rickettsial agents such as rickettsia akari and orientia tsutsugamushi. we screened dna extracts from 27 mites representing 25 species of dermanyssoids for rickettsial agents such as anaplasma, bartonella, rickettsia, and wolbachia by pcr amplification and sequencing. dna from anaplasma spp., a novel bartonella sp., spiroplasma sp., wolbachia sp., and an unclassified rickettsiales were detected in mite ...	2006	16596351
bartonella quintana endocarditis with positive serology for coxiella burnetii.	both bartonella quintana and coxiella burnetii are known to cause of blood culture negative endocarditis. in such case, the diagnosis is usually established by serology. a case of bartonella quintana endocarditis is described where the serology was falsely positive for coxiella burnetii. this case demonstrates the difficulty in distinguishing these two etiologic agents by routine serologic testing.	2006	16386308
antiangiogenic effect of erythromycin: an in vitro model of bartonella quintana infection.	bartonella quintana, the etiological agent of bacillary angiomatosis (ba), causes endothelial cell proliferation. erythromycin has dramatic effects on ba, and the effects are largely unexplained by the compound's bacteriostatic properties. our aim here was to evaluate the possibility that erythromycin alters angiogenesis.	2006	16388485
effects of cow age and pregnancy on bartonella infection in a herd of dairy cattle.	bartonella spp. are small hemotropic bacteria infecting mammals. four bartonella species have been recently described in cattle and wild ruminants. to date, the biology and possible pathogenic role of bartonella species isolated from ruminants are poorly understood. therefore, a dairy herd of 448 cows and heifers was surveyed in order to establish the prevalence of bartonella bovis and b. chomelii infections, the level of bacteremia, and the relationship between bacteremia and age or pregnancy s ...	2006	16390945
first isolation of bartonella alsatica from a valve of a patient with endocarditis.	we report the first documented case of endocarditis in a man infected with bartonella alsatica, which causes bacteremia in healthy wild rabbits. b. alsatica was identified by serology and culture and by pcr of an aortic valve specimen. b. alsatica should be added to the list of zoonotic agents of blood culture-negative endocarditis.	2006	16390990
bartonella henselae infection associated with guillain-barre syndrome.	this is the first report of guillain-barré syndrome (gbs) related to bartonella henselae infection. a 10-year-old girl had difficulty walking and marked myalgia. the search for all causes known to trigger gbs was negative. she was treated with intravenous immunoglobulins and recovered. because she lived in a rural area and had a history of kitten contact, a specific serology for b. henselae infection was performed and confirmed an ongoing infection. she did not show any clinical typical feature ...	2006	16395116
purification of the yada membrane anchor for secondary structure analysis and crystallization.	non-fimbrial adhesins, such as yersinia yada, moraxella uspa1 and a2, haemophilus hia and hsf, or bartonella bada, represent an important class of molecules by which pathogenic proteobacteria adhere to their hosts. they form trimeric surface structures with a head-rod-anchor architecture. whereas their head and rod domains may be of heterologous origin, their anchor domains are homologous and display the properties of autotransporters. conflicting topology models exist for these membrane anchors ...	2006	16405993
dna examination of ancient dental pulp incriminates typhoid fever as a probable cause of the plague of athens.	until now, in the absence of direct microbiological evidence, the cause of the plague of athens has remained a matter of debate among scientists who have relied exclusively on thucydides' narrations to introduce several possible diagnoses. a mass burial pit, unearthed in the kerameikos ancient cemetery of athens and dated back to the time of the plague outbreak (around 430 bc), has provided the required skeletal material for the investigation of ancient microbial dna.	2006	16412683
[fleas and diseases transmissible to man].	fleas are wingless insects that parasitize mammals and more rarely birds. they are able to jump and may bite people. adult fleas are hematophagous. the impact of fleas on public health is related to their ability to act as vectors for transmission of infectious agents during blood meals. the purpose of this article is to describe fleas and the diseases that they transmit to humans. special focus is placed on epidemiological aspects.	2006	16615611
bartonella henselae pap31, an extracellular matrix adhesin, binds the fibronectin repeat iii13 module.	bartonella henselae wound-associated infections suggest involvement of extracellular matrix molecules in adhesion and invasion. pap31 was previously identified as a hemin-binding protein. our recent studies suggest the protein is an adhesin that is recognized by the host's immune systems. in this study we examined the interactions of b. henselae pap31 with fibronectin (fn), heparin (hep), and human umbilical vein endothelial cells (huvecs). the cloned gene was expressed in escherichia coli, and ...	2006	16622186
cat-scratch disease in veterinary-associated populations and in its cat reservoir in taiwan.	in taiwan, the first human case of cat-scratch disease (csd) was diagnosed by a serologic test in 1998. since then, no studies have been conducted to understand the epidemiology of the infection in taiwan. therefore, this study is the first epidemiologic survey of csd in cats and humans in this country. using veterinary-associated individuals as the study population, it was identified that 1.7% of them were seropositive for b. henselae, and residence was the only factor associated with seroposit ...	2006	16641017
images in clinical medicine. cat scratch disease lymphadenopathy.		2006	16641391
parotid mass due to cat scratch disease.	cat scratch disease (csd), due to bartonella henselae, is a self-limited chronic lymphadenopathy. a previously healthy 22-year-old woman presented with a palpable painful swelling in the right submandibular region accompanied by enlarged cervical lymph nodes. a diagnosis of b. henselae infection was made according to her personal history that divulged frequent contacts with cats and to a high titre of immunoglobulin g (igg) and igm antibodies for this agent. the patient improved within 1 month w ...	2006	16669837
systemic granulomatous disease and sialometaplasia in a dog with bartonella infection.	systemic granulomatous disease involving the spleen, heart, lymph nodes, omentum, liver, kidney, lung, mediastinum, and salivary glands developed in an 8-year-old rottweiler. the dog also had sialometaplasia of both submandibular salivary glands. bartonella henselae and b. vinsonii subsp. berkhoffii dna was amplified from the salivary gland by polymerase chain reaction analysis. bartonellae may be the cause of this systemic disease, but to the authors' knowledge, involvement of omentum, mediasti ...	2006	16672593
model structure of the prototypical non-fimbrial adhesin yada of yersinia enterocolitica.	non-fimbrial adhesins, such as yersinia yada, moraxella uspa1 and a2, haemophilus hia and hsf, or bartonella bada represent an important class of molecules by which pathogenic proteobacteria adhere to their hosts. they form trimeric surface structures with a head-stalk-anchor architecture. whereas head and stalk domains are diverse and appear (frequently repetitively) in different combinations, the anchor domains are homologous and display the properties of autotransporters. we have built a mole ...	2006	16675268
[cat-scratch disease. review of eight adult patients hospitalized for fever or adenopathy].	cat-scratch disease is common among children. among adults the disease is less often considered in the differential diagnosis of enlarged lymph nodes and fever.	2006	17186093
[wild small mammals are the reservoir hosts of the bartonella genus bacteria in the south of moscow region].	a total of 103 blood samples collected from wild small mammals captured in the prioksko-terrasny reserve on the south of moscow region were studied to determine the bartonellae prevalence. the examined species were the yellow-necked mice apodemus flavicollis (35 samples), the european wood mouse apodemus uralensis (10 samples), the bank vole clethrionomys glareolus (51 samples), the house mouse mus musculus (3 samples), the common vole microtus arvalis (2 samples), and the shrew sorex araneus (2 ...	2006	17094651
lymph node biopsy specimens and diagnosis of cat-scratch disease.	we report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (csd). the specimens were examined by standard, cell culture, and molecular methods. infectious agents were found in samples from 391 (49.7%) of 786 patients. the most commonly identified infectious agent was bartonella henselae (245 patients, 31.2%), the agent of csd. mycobacteriosis was diagnosed in 54 patients (6.9%) by culture and retrospectively confirmed by using a specific ...	2006	17073081
bartonella quintana, lice, and molecular tools.		2006	17017209
dynamics of the incw genetic backbone imply general trends in conjugative plasmid evolution.	plasmids cannot be understood as mere tools for genetic exchange: they are themselves subject to the forces of evolution. their genomic and phylogenetic features have been less studied in this respect. focusing on the incw incompatibility group, which includes the smallest known conjugative plasmids, we attempt to unveil some common trends in plasmid evolution. the functional modules of incw genetic backbone are described, with emphasis on their architecture and relationships to other plasmid gr ...	2006	17026718
secondary unilateral glaucoma and neuroretinitis: atypical manifestation of cat-scratch disease.		2006	16604397
experimental infection of human body lice with acinetobacter baumannii.	the human body louse is currently recognized as a vector of rickettsia prowazekii, borrelia recurrentis, and bartonella quintana. previous studies have reported the isolation of acinetobacter baumannii from the body lice of homeless patients. to study how the body louse acquires a. baumannii, we infected a rabbit by infusing 2 x 10(6) colony-forming units of the louse strain of a. baumannii. two hundred body lice were infected by feeding on the bacteremic rabbit and compared with 200 uninfected ...	2006	16606978
molecular detection of rickettsia felis, rickettsia typhi and two genotypes closely related to bartonella elizabethae.	a total of 56 fleas were collected from mice, rats, and one hedgehog in national parks of mainland portugal and the madeira island. all fleas were tested for the presence of bacteria of the genera rickettsia and bartonella using pcr assays. in fleas from mainland portugal, we detected rickettsia felis in one archaeopsylla erinacei maura flea and in one ctenophtalmus sp. in five leptopsylla segnis fleas taken from rats in the madeira island, we identified rickettsia typhi. in addition, in four fl ...	2006	17038702
the reach of the genome signature in prokaryotes.	with the increased availability of sequenced genomes there have been several initiatives to infer evolutionary relationships by whole genome characteristics. one of these studies suggested good congruence between genome synteny, shared gene content, 16s ribosomal dna identity, codon usage and the genome signature in prokaryotes. here we rigorously test the phylogenetic signal of the genome signature, which consists of the genome-specific relative frequencies of dinucleotides, on 334 sequenced pr ...	2006	17040564
isolated hepatic involvement of cat scratch disease in immunocompetent adults: enhanced magnetic resonance imaging, pathological findings, and molecular analysis--two cases.	visceral involvement in absence of lymphadenopathy is a rare manifestation in cat scratch disease; hepatic granulomas are rare, representing 0.3% of systemic manifestations of cat scratch disease, and gallbladder extension is a singular case. the present article refers to 2 rare cases of visceral cat scratch disease in immunocompetent adults with hepatic granulomatous inflammation, caused by bartonella henselae infection, with gallbladder involvement in 1 case and no lymphadenopathy. histologica ...	2006	17041206
immunohistochemical study of lymph nodes in patients with cat scratch disease.	bartonella henselaeis the causative agent of cat scratch disease (csd), manifesting as fever and acute regional lymphadenopathy. although serologic testing is the reference method for diagnosis, successful use of immunohistochemical (ihc) stain of regional lymph nodes for the diagnosis of csd has been reported. to determine the characterization and diagnostic potential of ihc in lymphadenopathy of csd, lymph nodes were excised from patients with suspected csd for further evaluation.	2006	17098692
indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following listeria monocytogenes infection.	control of pathogens by formation of abscesses and granulomas is a major strategy of the innate immune system, especially when effector mechanisms of adaptive immunity are insufficient. we show in human listeriosis that dcs expressing indoleamine 2,3-dioxygenase (ido), together with macrophages, are major cellular components of suppurative granulomas in vivo. induction of ido by dcs is a cell-autonomous response to listeria monocytogenes infection and was also observed in other granulomatous inf ...	2006	17111046
bartonella henselae endocarditis in a child.	14-year-old white male with a past medical history of congenital bicuspid aortic valve, streptococcus viridans endocarditis, and pulmonary valve homograft presented with culture-negative endocarditis. molecular studies identified the causative organism as bartonella henselae and subsequent serologic studies supported this diagnosis. this rare cause of endocarditis may be under recognized in children. bartonella henselae endocarditis should be considered in all children with culture-negative endo ...	2006	17111290
infective endocarditis due to bartonella spp. and coxiella burnetii: experience at a cardiology hospital in sao paulo, brazil.	bartonella spp. and coxiella burnetii are recognized as causative agents of blood culture-negative endocarditis (bcne) in humans and there are no studies of their occurrences in brazil. the purpose of this study is to investigate bartonella spp. and c. burnetii as a causative agent of culture-negative endocarditis patients at a cardiology hospital in são paulo, brazil. from january 2004 to december 2004 patients with a diagnosis of endocarditis at our institute were identified and recorded prosp ...	2006	17114712
arthropod-borne diseases in homeless.	homeless people are particularly exposed to ectoparasite. the living conditions and the crowded shelters provide ideal conditions for the spread of lice, fleas, ticks, and mites. body lice have long been recognized as human parasites and although typically prevalent in rural communities in upland areas of countries close to the equator, it is now increasingly encountered in developed countries especially in homeless people or inner city economically deprived population. fleas are widespread but ...	2006	17114713
prevalence of rickettsia felis-like and bartonella spp. in ctenocephalides felis and ctenocephalides canis from la rioja (northern spain).	our aim was to determine the presence of rickettsia spp. and bartonella spp. in ctenocephalides felis and ctenocephalides canis from la rioja (spain). a total of 88 specimens were tested by polymerase chain reaction (pcr) using glta and ompb genes as targets for rickettsia spp., and 16s rrna and ribc genes for bartonella spp. rickettsia felis-like (28.4%), bartonella clarridgeiae (6.8%), and bartonella henselae (3.4%) were detected in ctenocephalides spp. other bartonella sp. different from b. c ...	2006	17114721
population survey of egyptian arthropods for rickettsial agents.	between june 2002 and july 2003, 987 fleas, representing four species, and 1019 ticks, representing one argasid and eight ixodid species, were collected from egyptian animals. these arthropods were tested for rickettsial agents using polymerase chain reaction. dnas from anaplasma and ehrlichia spp. were detected in 13 ticks. previously undescribed bartonella spp. were detected in 21 fleas. coxiella burnetii was detected in two fleas and 20 ticks. rickettsia typhi was detected in 27 fleas from 10 ...	2006	17114742
bartonella infection in domestic cats and wild felids.	bartonella are vector-borne, fastidious gram-negative bacteria causing persistent bacteremia in their reservoir hosts. felids represent a major reservoir for several bartonella species. domestic cats are the main reservoir of b. henselae, the agent of cat-scratch disease. prevalence of infection is highest in warm and humid climates that are optimal for the survival of cat fleas, as fleas are essential for the transmission of the infection. flea feces are the likely infectious substrate. prevale ...	2006	17114749
corpuscular antigenic microarray for the serodiagnosis of blood culture-negative endocarditis.	blood culture-negative endocarditis is due to fastidious bacteria, including coxiella burnetii and bartonella spp. diagnosis of such infection relies on serology and microimmunofluorescence is therefore the reference method. we developed a multiplex serology test featuring automatic incubation and reading and incorporating internal controls. preliminary results indicate that this new serologic test is valuable for the rapid, automated serological diagnosis of blood culture-negative endocarditis.	2006	17114786
a translocated bacterial protein protects vascular endothelial cells from apoptosis.	the modulation of host cell apoptosis by bacterial pathogens is of critical importance for the outcome of the infection process. the capacity of bartonella henselae and b. quintana to cause vascular tumor formation in immunocompromised patients is linked to the inhibition of vascular endothelial cell (ec) apoptosis. here, we show that translocation of bepa, a type iv secretion (t4s) substrate, is necessary and sufficient to inhibit ec apoptosis. ectopic expression in ecs allowed mapping of the a ...	2006	17121462
[endocarditis due to bartonella spp. three new clinical cases and spanish literature review].		2006	17125688
[prevalence of bartonella henselae antibodies in chilean children, adolescents and veterinary workers].	bartonella henselae is the causative agent of cat-scratch disease.	2006	17130969
transient paresis associated with cat-scratch disease: case report and literature review of vertebral osteomyelitis caused by bartonella henselae.	cat-scratch disease (csd) rarely presents as vertebral osteomyelitis. we describe a case with paresis of the arm with total recovery after antibiotic and neurosurgical therapy. we reviewed 20 other cases of csd vertebral osteomyelitis in the literature. this diagnosis should be considered in patients with systemic symptoms, back pain, and cat contact. the prognosis is generally good.	2006	17133166
an unusual outcome in a child with hepatosplenic cat-scratch disease.	typical cat-scratch disease (bartonella henselae infection) in an immunocompetent child is usually associated with a history of scratch, bite or intimate contact with a cat. most patients develop a non-tender papule in the scratch line after three to ten days. this may persist for only a few days or as long as two to three weeks. during the next two weeks or more, regional lymph nodes that drain the area gradually enlarge and then slowly resolve in more than 10% of patients. the nodes develop ov ...	2006	17136337
[bacterial zoonoses: emerging concepts].	bacterial zoonoses are evolving with changes in society, climate and lifestyles. a hierarchy of non food-borne zoonoses was recently proposed in france, and includes characteristics such as severity criteria and bioterrorism potential. the creation of specific networks and reference centers has provided the means to monitor the emergence (or re-emergence) of zoonoses such as brucellosis and q fever. molecular tools have facilitated the detection of bacteria that are transmitted by arthropod vect ...	2006	17140097
demographic features of bartonella infections in richardson's ground squirrels (spermophilus richardsonii).	the epidemiology of bartonella infections in richardson's ground squirrels (spermophilus richardsonii) was studied at multiple sites in saskatchewan, canada, from 2002 to 2004. the overall prevalence of bartonella infection was 48%. juvenile squirrels were significantly more likely to be infected with bartonella than were adults (58% and 37%, respectively), and juvenile animals also were significantly more likely to have high levels of bacteremia compared to adult animals. prevalence of bartonel ...	2006	17255440
effect of experimental ectoparasite control on bartonella infections in wild richardson's ground squirrels.	the purpose of this study was to investigate the role of ectoparasites in transmitting bartonella infections in wild richardson's ground squirrels (spermophilus richardsonii). richardson's ground squirrels were trapped, examined for fleas, and tested for bartonella bacteremia once monthly, at six sites, from april to september 2004. after the initial trapping session in april, burrows at three sites were treated with deltamethrin insecticide. richardson's ground squirrels trapped on treated site ...	2006	17255441
serologic survey of eptesicus fuscus from georgia, u.s.a. for rickettsia and borrelia and laboratory transmission of a rickettsia by bat ticks.	bats and their ectoparasites are associated with bacterial agents of unknown pathogenicity. we tested sera from 56 eptesicus fuscus from georgia against borrelia hermsii, orientia tsutsugamushi, rickettsia conorii, and rickettsia rickettsii. we detected antibodies reactive against a relapsing fever borrelia and spotted fever group rickettsia in 3/56 and 1/56 bats, respectively. we attempted to culture bartonella from the blood of these bats but were unsuccessful. in addition, we fed bat ticks, c ...	2006	17249357
bartonella infections in fleas (siphonaptera: pulicidae) and lack of bartonellae in ticks (acari: ixodidae) from hungary.	fleas (95 pulex irritans, 50 ctenocephalides felis, 45 ctenocephalides canis) and ixodid ticks (223 ixodes ricinus, 231 dermacentor reticulatus, 204 haemaphysalis concinna) were collected in hungary and tested, in assays based on pcr, for bartonella infection. low percentages of p. irritans (4.2%) and c. felis (4.0%) were found to be infected. the groel sequences of the four isolates from p. irritans were different from all the homologous sequences for bartonellae previously stored in genbank bu ...	2006	17252927
[serous macular detachment as an atypical sign in cat scratch disease].	case report: a 58-year-old woman presented with 0.1 visual acuity in the left eye associated with a serous retinal detachment of the macula as the only ocular manifestation of cat scratch disease. this diagnosis was made by serum antibody titers and the clinical course. discussion: although uncommon, cat scratch disease should be considered in patients with a serous detachment in the macula region of the retina.	2006	17199167
[phlebotomine sandflies and transmission of disease agents around the mediterranean basin].	around 800 species of phlebotomine sandflies are widely distributed in tropical and temperate areas. some sand flies are documented vectors of human disease agents including parasitic protozoa, (leishmania spp), bacteria (bartonella bacilliformis) and viruses (phlebovirus). in addition to presenting morphologic, taxonomic and biologic aspects of phlebotomine sandflies, this report focuses on ecologic, epidemiologic, ethologic, and anthropic factors contributing to the proliferation of sand flies ...	2006	17201284
the low seroprevalence of tick-transmitted agents of disease in dogs from southern ontario and quebec.	infectious diseases caused by pathogens transmitted by ticks and other insect vectors are an important cause of morbidity and mortality in both dogs and humans throughout north america. the purpose of this study was to determine the seroprevalence of selected vector-transmitted pathogens in southern ontario and quebec. samples submitted to the vector borne disease diagnostic laboratory (vbddl) at the north carolina state university college of veterinary medicine were evaluated for antibodies to ...	2006	17217089
[rash and purulent lymphadenitis in cat scratch disease].	we present a case of a cat-scratch disease (csd) presenting with typical (primary lesion and regional lymphadenitis) and rare (purulent lymphadenitis and maculopapular rash) symptoms and positive epidemiological data. laboratory blood test showed normal values for routine parameters, except for mild leukocytosis (l 12.4 x 10(9)), elevated erythrocyte sedimentation rate (se 65/h) and moderately elevated asparta e-aminotransferase and alanine-aminotransferase values (ast/alt 48/90), fibrinogen (5. ...	2006	17217106
diversity of bartonella genotypes in richardson's ground squirrel populations.	the diversity and dynamics of bartonella genotypes found in wild richardson's ground squirrels (rgs), spermophilus richardsonii were monitored at multiple sites in saskatchewan, canada from 2002 to 2004. based on sequence analysis of a portion of the bartonella citrate synthase (glta) gene, four different genotypes were detected in 233 isolates from 176 animals. the majority (87%) of sequences were identified as genotype h, with genotypes i, j, and k accounting for 8%, 4%, and 1% of sequences, r ...	2006	17187575
[bartonella henselae as a cause of optical nerve neuritis].	bartonella henselae is included into the group of gram-negative bacteria that can cause not so rare disease known as cat-scratch disease (csd). this disease is characterized by the specific general symptoms, and the complications in the eyes can be manifested in the form of neuroretinitis, follicular conjunctivitis and focal chorioretinitis. in this paper clinical and epidemiological characteristics of a patient with ophthalmologic complications caused by bartonella henselae are described. we in ...	2006	17144434
bartonella quintana endocarditis in dogs.	we provide the first evidence that bartonella quintana can infect dogs and cause typical signs of endocarditis. using pcr and sequencing, we identified b. quintana in the blood of a dog from the united states with aortic valve endocarditis and probably also in the mitral valve of a dog from new zealand with endocarditis.	2006	17326937
bartonellosis: suggestive case reports in adult and pediatric patients and therapeutic issues.	cat-scratch disease warrants extensive investigation, from an epidemiological, a diagnostic, but especially a therapeutic point of view. two suggestive episodes of bartonella henselae-caused cat-scratch disease are reported, and discussed in the light of the most recent literature evidence. the first case occurred in a 60-year-old man, thus suggesting that it is important to maintain an elevated level of suspicion for this disease in adults as well. both episodes were characterized by a very pro ...	2006	17420917
role of dendritic cell-derived cxcl13 in the pathogenesis of bartonella henselae b-rich granuloma.	dendritic cells (dcs) initiate adaptive immunity and regulate the inflammatory response by producing inflammatory chemokines. this study was aimed to elucidate their role in the pathogenesis of the suppurative granuloma induced by bartonella henselae infection, which characterizes cat scratch disease (csd). in vitro dc infection by b. henselae results in internalization of bacteria, phenotypic maturation with increased expression of hla-dr and cd86, and induction of cd83, cd208, and ccr7. in com ...	2006	16189275
prevalence of bartonella species, haemoplasma species, ehrlichia species, anaplasma phagocytophilum, and neorickettsia risticii dna in the blood of cats and their fleas in the united states.	ctenocephalides felis were killed and collected from 92 cats in alabama, maryland, and texas. the fleas and blood from the corresponding cat were digested and assessed in polymerase chain reaction assays that amplify dna of ehrlichia species, anaplasma phagocytophilum, neorickettsia risticii, mycoplasma haemofelis, 'candidatus m haemominutum' and bartonella species. dna consistent with b henselae, b clarridgeiae, m haemofelis, or 'candidatus m haemominutum' was commonly amplified from cats (60.9 ...	2006	16290092
evidence for louse-transmitted diseases in soldiers of napoleon's grand army in vilnius.	many soldiers in napoleon's grand army died of infectious diseases during its retreat from russia. because soldiers were commonly infested with body lice, it has been speculated that louse-borne infectious diseases, such as epidemic typhus (caused by rickettsia prowazekii), were common.	2006	16323139
plasmacytoid monocytes in cat scratch disease with special reference to the histological diversity of suppurative lesions.	it has been suggested that plasmacytoid monocytes (pmos) play an essential role in t-cell-dependent immune response. indeed, numerous pmos are found in close topographical association with epithelioid cell granulomas in hypersensitivity-type granulomas, such as tuberculosis and sarcoidosis. the key pathologic process in cat scratch disease (csd) usually involves a b-cell-associated granulomatous reaction. histologically, csd appears to exhibit a histopathologic diversity, including suppurative l ...	2006	16352403
kikuchi's disease or kikuchi's syndrome?		2006	16421809
transient monoclonal gammopathy in a patient with bartonella quintana endocarditis.	monoclonal gammopathy has been reported rarely in association with infectious diseases. viral infection has been the most frequently reported. we report a case of bartonella quintana endocarditis in a 45-year-old homeless male associated with a monoclonal igg kappa gammopathy. the gammopathy disappeared after 8 months of antibiotics while the bartonella antibody titre was decreasing. this correlation suggests a causative role for b. quintana for the monoclonal gammopathy. to the best of our know ...	2006	16432867
serological survey of vector-borne zoonotic pathogens in pet cats and cats from animal shelters and feral colonies.	although cats and their arthropod parasites can sometimes be important sources of zoonotic diseases in humans, the extent of exposure among various cat populations to many potential zoonotic agents remains incompletely described. in this study, 170 domestic cats living in private homes, feral cat colonies, and animal shelters from california and wisconsin were evaluated by serology to determine the levels of exposure to a group of zoonotic vector-borne pathogens. serological positive test result ...	2006	16434226
confirmation of diagnosis of cat scratch disease by immunohistochemistry.		2006	16434905
[diagnostic imaging (257). a boy with a swollen inguinal gland].	in a 4-year-old boy with left-sided inguinal lymphadenopathy and a papule on his left lower leg situated at the end of a scar of a probable cat scratch, cat scratch disease was confirmed serologically.	2006	16440563
prevalence of selected infectious disease agents in cats from arizona.	the objective of this study was to use polymerase chain reaction (pcr) assays to determine the prevalence of ehrlichia species, anaplasma phagocytophilum, mycoplasma haemofelis, 'candidatus mycoplasma haemominutum' and bartonella species from feral and relinquished cats in phoenix and nogales, arizona. dna from one or more of the organisms was amplified from 31 of 112 blood samples (27.7%). dna consistent with bartonella clarridgeiae 15 (13.4%), bartonella henselae 14 (12.5%), 'candidatus m haem ...	2006	16443383
antibodies to rickettsia rickettsii, rickettsia typhi, coxiella burnetii, bartonella henselae, bartonella quintana, and ehrlichia chaffeensis among healthy population in minas gerais, brazil.	rickettsial diseases except those belonging to spotted fever group rickettsioses are poorly studied in south america particularly in brazil where few epidemiological reports have been published. we describe a serosurvey for rickettsia rickettsii, r. typhi, coxiella burnetii, bartonella henselae, b. quintana, and ehrlichia chaffeensis in 437 healthy people from a brazilian rural community. the serum samples were tested by indirected micro-immunoflourescence technique and a cutoff titer of 1:64 wa ...	2006	16444416
[presence of bartonella henselae in cats: natural reservoir quantification and human exposition risk of this zoonoses in chile].	the availability of a serologic test for cat scratch disease in humans has allowed the diagnosis of an increasing number of cases of this disease in chile.	2006	16446874
hepatic peliosis (bacillary angiomatosis) in aids: ct findings.		2006	16447083
bartonella quintana associated neuroretinitis.	we report an observational case of bartonella quintana-associated neuroretinitis. the patient had a positive igm ifa titer for bartonella quintana early in the disease. after treatment, the neuroretinitis and igm resolved. given the patient's history, symptoms, response to treatment, and igm course, we believe his neuroretinitis was secondary to bartonella quintana.	2006	16449005
bacillary angiomatosis associated with pseudoepitheliomatous hyperplasia.	bacillary angiomatosis is an opportunistic bacterial infection caused by either bartonella henselae or b. quintana. the classic histologic presentation of bacillary angiomatosis involves three components: a lobular proliferation of capillaries with enlarged endothelial cells, neutrophilic debris, and clumps of finely granular material identified as bacteria with staining techniques. pseudoepitheliomatous hyperplasia is a histologic reaction pattern characterized by epithelial proliferation in re ...	2006	16456322
ocular manifestation of cat-scratch disease in hiv-positive patients.	to characterize ocular manifestations of cat-scratch disease in hiv-positive patients.	2006	16458711
a bartonella vinsonii berkhoffii typing scheme based upon 16s-23s its and pap31 sequences from dog, coyote, gray fox, and human isolates.	since the isolation of bartonella vinsonii subspecies berkhoffii from a dog with endocarditis in 1993, this organism has emerged as an important pathogen in dogs and as an emerging pathogen in people. current evidence indicates that coyotes, dogs and gray foxes potentially serve as reservoir hosts. based upon sequence differences within the 16s-23s its region and pap31 gene, we propose a classification scheme that divides b. vinsonii subsp. berkhoffii isolates into four distinct types. two conse ...	2006	16460911
antimicrobial susceptibility of bartonella henselae using etest methodology.	bartonella henselae is a fastidious slow growing pathogen which is seldom cultured in the laboratory. previous descriptions of antimicrobial susceptibility have been largely limited to feline isolates and/or laboratory reference strains, with no accounting for genotypic or phenotypic diversity.	2006	16464897
a serological study of exposure to arthropod-borne pathogens in dogs from northeastern spain.	there is limited information regarding the prevalence of many vector borne pathogens in europe and especially in spanish dogs. we investigated 206 sick and 260 clinically healthy dogs from three different regions in northeastern spain for antibodies to rickettsia conorii (rc), ehrlichia canis (ec), anaplasma phagocytophilum (ap), bartonella henselae (bh), bartonella vinsonii subsp. berkhoffii (bvb), leishmania infantum (li) and borrelia burgdorferi (bb) and for antigen of dirofilaria immitis (di ...	2006	16472522
antibodies to bartonella vinsonii subsp. berkhoffii in moroccan dogs.	bartonella vinsonii subsp. berkhoffii is a fastidious microorganism that has been recognized as an emerging human and canine pathogen. we report for the first time on the prevalence of antibodies to b. vinsonii subsp. berkhoffii in domestic dogs from morocco. the overall seroprevalence was 38% (56 of 147 dogs tested). most of the seropositive dogs were stray dogs from rabat (36%, 8 of 22) and khenifra (47%, 47 of 101). antibodies against b. vinsonii subsp. berkhoffii were found infrequently amon ...	2006	16474074
bartonellae as elegant hemotropic parasites.	bartonella species are hemotropic bacterial parasites of a wide range of mammals that occasionally cause disease in humans. the low prevalence of clinical manifestations compared to the high prevalence of infection underlines the elegance of these parasites that carefully exploit their hosts in a manner that optimizes their transmission. recent research efforts have begun to determine the strategies involved in this exploitation, and significant progress has been made in unraveling an unusually ...	2005	16481527
production of recombinant protein pap31 and its application for the diagnosis of bartonella bacilliformis infection.	tropical bartonellosis is a highly fatal epidemic and endemic infectious disease that occurs throughout the communities of the andes mountains in south america. the disease is caused by the facultative intracellular bacteria, bartonella bacilliformis. the emergence of bartonellosis in new geographic areas and an increase in the number of reported cases suggest the need for a rapid test for epidemiologic study and investigation of the disease burden. the objective of this research is to develop a ...	2005	16481528
bartonella bacilliformis groel: effect on growth of human vascular endothelial cells in infected cocultures.	bartonella are the only bacteria known to induce angioproliferative lesions of the human vasculature and liver during infection. previous work from our lab suggests that groel participates in the mitogenic response observed in huvec cultures supplemented with the soluble fraction of bartonella bacilliformis. work in this study shows that exposure to high concentrations of the fraction is actually cytotoxic for huvecs. to analyze this phenomenon, live b. bacilliformis-huvec cocultures were employ ...	2005	16481529
occurrence of bartonella henselae and bartonella quintana among human immunodeficiency virus-infected patients.	the purpose of this study was to determine the seroprevalence against bartonella henselae and bartonella quintana among a risk group, patients with hiv infection, and to identify the epidemiological factors involved. our data indicate that the prevalence of bartonella infection among hiv-infected patients is much greater than that in the healthy population of the same area and that bartonella infection should be considered in the differential diagnosis for patients with hiv disease.	2005	16481530
bacillary angiomatosis caused by bartonella quintana.	bacillary angiomatosis is a disorder of neovascular proliferation involving skin and lymph nodes of immunosuppressed patients. bartonella henselae or bartonella quintana have been inculpated as causative by direct culture or pcr amplification of dna sequences. here, we report the clinical evolution of a patient infected with human immunodeficiency virus (hiv) whose b. quintana infection was diagnosed by pcr.	2005	16481531
molecular screening of bartonella species in rodents from the russian far east.	a potentially broad-range pcr system for glta gene amplification has been designed. a nearly full (992 bp) sequence of the glta gene was amplified in two steps. dna was extracted from organs (spleen and liver) of four mostly spread species of rodents: apodemus agrarius and apodemus peninsulae mice; clethrionomys rufocanus and microtus fortis voles. all amplicons have been sequenced. the incidence of bartonella species in rodents was 73%, 60%, 60%, and 83% for the above-mentioned rodents, respect ...	2005	16481532
characterization of genes involved in long-term bacteremia in mice by bartonella birtlesii.		2005	16481533
bartonella henselae in porpoise blood.	we report detection of bartonella henselae dna in blood samples from 2 harbor porpoises (phocoena phocoena). by using real-time polymerase chain reaction, we directly amplified bartonella species dna from blood of a harbor porpoise stranded along the northern north carolina coast and from a pre-enrichment blood culture from a second harbor porpoise. the second porpoise was captured out of habitat (in a low-salinity canal along the northern north carolina coast) and relocated back into the ocean. ...	2005	16485476
bartonella quintana in cynomolgus monkey (macaca fascicularis).	we identified a bartonella quintana strain by polymerase chain reaction amplification, cloning, and sequencing of dna extracted from lysed erythrocytes and cultured colonies grown from peripheral blood collected from a captive-bred cynomolgus monkey (macaca fascicularis). this report describes naturally acquired b. quintana infection in a nonhuman primate.	2005	16485482
[cat-scratch disease as cause of lymphadenitis colli].	cat-scratch disease as cause of lymphadenitis colli. cat-scratch disease is a frequent cause of lymphadenitis colli. it mainly affects children and adolescents younger than 21 years. since the clinical picture is not characteristic, a history of contact to cats or kittens is highly valuable for diagnosing the disease. major aspects of the disease concerning epidemiology, diagnostic procedures, clinical presentation and therapy are discussed.	2005	16358204
[inguinal mass as presentation of cat-scratch disease].		2005	16358433
comparative proteomic analysis of b. henselae houston and b. henselae marseille by two-dimensional gel electrophoresis.	to compare the protein difference between b. henselae houston and b. henselae marseille by two-dimensional gel electrophoresis.	2005	16370318
[cat-scratch disease].	to study the etiology, epidemiology, clinical and pathological features, diagnose and treatment of cat-scratch disease(csd).	2005	16375109
clinicopathologic findings in dogs seroreactive to bartonella henselae antigens.	to assess the potential clinical relevance of seroreactivity to bartonella henselae antigens in dogs.	2005	16379647
[prevalence of serum antibodies against bartonella ssp. in a health population from the south area of the seville province].	to know the prevalence of serum antibodies against bartonella spp. in a healthy population from south of spain.	2005	16381097
pattern visual evoked potentials in eyes with disc swelling due to cat scratch disease-associated neuroretinitis.	to evaluate optic nerve function by pattern visual evoked potentials (veps) in eyes with optic disc swelling due to neuroretinitis associated with cat scratch disease (csd).	2005	16328936
aortic valve endocarditis with bartonella quintana - a rare entity.	endocarditis caused by bartonella species is difficult to diagnose and still remains a rare entity. therefore, a young male patient undergoing aortic valve replacement for culture-negative endocarditis is reported in whom the diagnosis of a bartonella quintana infection was made with a great delay postoperatively.	2005	16331372
[detection of the bartonella dna by the method of nested pcr in patients after tick bites in novosibirsk region].	arthropod-borne bacterial pathogen bartonella dna was detected in human blood cells after tick bites in summer 2003 and 2004 in novosibirsk region by nested pcr with primers specific to groel gene of hsp60 protein. comparative assay of 190 p.b. of long pcr fragment revealed that the nucleotide sequences might belong to bartonella henselae and bartonella quintana.	2005	16334219
bacterial 16s ribosomal dna in house dust mite cultures.	allergen extracts prepared from dermatophagoides farinae contain significantly more endotoxin than dermatophagoides pteronyssinus extracts, and extracts from both mite extracts contain more endotoxin than pollen extracts. attempts to culture bacteria from mite cultures have failed to establish the sources of the endotoxin.	2005	16337462
disseminated cat scratch disease with vertebral osteomyelitis and epidural abscess.	a 5-year-old boy with cat scratch disease presented with fever of unknown origin and osteomyelitis of the thoracic spine and epidural abscess. he did not have localizing signs or symptoms. computed tomography of the abdomen, which was initially negative, showed hepatosplenic disease. cat scratch disease has variable systemic presentations and should be included in the differential diagnosis of fever of unknown origin if an epidemiologic risk factor is present.	2005	16351038
detection of bartonella species from ticks, mites and small mammals in korea.	we investigated the prevalence of bartonella infections in ticks, mites and small mammals (rodents, insectivores and weasels) collected during 2001 through 2004, from various military installations and training sites in korea, using pcr and sequence analysis of 16s rrna, 23s rrna and groel heat shock protein genes. the prevalence of bartonella spp. was 5.2% (n = 1,305 sample pools) in ticks, 19.1% (n = 21) in mesostigmatid mites and 13.7% (n = 424 individuals) in small mammals. the prevalence wi ...	2005	16293997
[determination of antibody titer to bartonella henselae by indirect fluorescence antibody assay using b. henselae from domestic cats as antigen].		2005	16296330