Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| bacterial decolorization and detoxification of black liquor from rayon grade pulp manufacturing paper industry and detection of their metabolic products. | this study deals with the decolorization of black liquor (bl) by isolated potential bacterial consortium comprising serratia marcescens (gu193982), citrobacter sp. (hq873619) and klebsiella pneumoniae (gu193983). the decolorization of bl was studied by using the different nutritional as well as environmental parameters. in this study, result revealed that the ligninolytic activities were found to be growth associated and the developed bacterial consortium was efficient for the reduction of cod, ... | 2011 | 21482463 |
| different culture medium formulations induce variant protein expression patterns of outer membrane porins in klebsiella pneumoniae. | outer membrane porin (omp) expression has been shown to play an important role in antimicrobial resistance. in this study, we observed that ompk35 of klebsiella pneumoniae had varied expression profiles in different nutrient broths. the potential factors that could influence protein expression were assessed. k. pneumoniae (atcc 13883) was cultured into two commercial available nutrient broths and also into solutions of the individual ingredients. to ensure that ompk35 was detected, an ompk35 def ... | 2011 | 21482487 |
| comparative ceftaroline activity tested against pathogens associated with community-acquired pneumonia: results from an international surveillance study. | to document the spectrum of activity of ceftaroline, the active form of the prodrug, ceftaroline fosamil, a new cephalosporin with anti-methicillin-resistant staphylococcal activity, against a surveillance collection of clinical isolates obtained from the usa and europe during 2008-09. | 2011 | 21482572 |
| the incidence of postoperative meningitis in neurosurgery: an institutional experience. | introduction : meningitis is the most dreaded cause of morbidity and mortality in neurosurgical patients. the reported incidence of postoperative meningitis is quite varied 0.5-8%. material and methods : the study cohort included all the patients who underwent neurosurgery at the department of neurosurgery, national institute of mental health and neurological sciences, bangalore, india over a period of seven years (2001 - 2007). patients with culture positive meningitis were included for analysi ... | 2011 | 21483116 |
| bacteriologic and plasmid analysis of etiologic agents of conjunctivitis in lagos, nigeria. | background: conjunctivitis, an inflammation of the conjunctiva, is one of the most common eye problems affecting all age groups in nigeria. a better understanding of its epidemiology and the antibiotic susceptibility of etiologic bacterial agents is crucial for the initiation of preventive and therapeutic measures. this study determined the distribution and patterns of bacterial infections in nigerian patients with conjunctivitis. antibiotic resistance patterns and the plasmid profiles of these ... | 2011 | 21484175 |
| phytochemical screening and antibacterial activities of vernonia ambigua, vernonia blumeoides and vernonia oocephala (asteraceae). | some vernonia species (vernonia ambigua, vernonia blumeoides and vernonia oocephala) used in northern nigerian traditional medicine, were subjected to phytochemical screening using standard procedures. the antibacterial activity using the disc diffusion method as outlined by the nccls was carried out on klebsiella pneumoniae, streptococcus pyogenes, staphylococcus aureus, corynbacterium ulcerans, methicillin resistant staphylococcus aureus (mrsa), salmonella typhi, pseudomonas aeruginosa, shigel ... | 2011 | 21485703 |
| [emphysematous pyelonephritis: an unusual clinical onset]. | 2011 | 21487983 | |
| fever and an expanding pancreatic fluid collection. | 2011 | 21488532 | |
| identification of escherichia coli, klebsiella pneumoniae, and pseudomonas aeruginosa in blood cultures: a multicenter performance evaluation of a three-color peptide nucleic acid fluorescence in situ hybridization assay. | a multicenter evaluation was undertaken to evaluate the performance of a new three-color peptide nucleic acid fluorescence in situ hybridization assay that identifies isolates directly from blood cultures positive for gram-negative bacilli (gnb). the assay correctly identified 100% (186/186) of the escherichia coli isolates, 99.1% (109/110) of the klebsiella pneumoniae isolates, and 95.8% (46/48) of the pseudomonas aeruginosa isolates in this study. negative assay results were correctly obtained ... | 2011 | 21490185 |
| familial spread of a virulent clone of klebsiella pneumoniae causing primary liver abscess. | capsule-forming klebsiella pneumoniae k1 caused primary liver abscess in two household members of a family. the causative isolates had identical pulsed-field gel electrophoresis patterns and were determined to be sequence type 23. an additional member of the family was found to carry the same strain without clinical manifestation. | 2011 | 21490191 |
| characterization of metallo-{beta}-lactamase vim-27, an a57s mutant of vim-1 associated with klebsiella pneumoniae st147. | vim-27 metallo-β-lactamase, an ala(57)→ser variant of vim-1, was identified in three klebsiella pneumoniae isolates belonging to sequence type 147. bla(vim-27) was part of a class 1 integron carried by non-self-transferable plasmids. kinetic parameters and mic determinations indicated that vim-27 hydrolyzed less effectively than vim-1 most β-lactams, especially imipenem and cefoxitin. | 2011 | 21518835 |
| dissemination of multiple drug resistance genes by class 1 integrons in klebsiella pneumoniae isolates from four countries: a comparative study. | a comparative genetic analysis of 42 clinical klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to broad-spectrum ß-lactam group, sourced from sydney (australia) and three south american countries is presented. the study focuses on the genetic contexts of class 1 integrons, a mobilizable genetic element best known for their role in the rapid evolution of antibiotic resistance amongst gram-negative pathogens. it was found that the class 1 integrons in this cohort were ... | 2011 | 21518841 |
| gram-negative neonatal osteomyelitis: two case reports. | neonatal osteomyelitis is a rare and challenging diagnosis, particularly in the early onset period. neonatal osteomyelitis is predominantly caused by staphylococcus aureus with single bone involvement. here, we report two cases of neonatal osteomyelitis in premature infants caused by klebsiella pneumoniae with multiple bone lesions. both cases presented with sepsis and meningitis and were initially diagnosed by incidental findings on plain films, with follow-up bone scan imaging. in both cases, ... | 2011 | 21520681 |
| identification of unknown ocular pathogens in clinically suspected eye infections using ribosomal rna gene sequence analysis. | clin microbiol infect 2011; 17: 776-779 abstract: dna sequence-based identification of pathogens from ocular samples of patients with clinically suspected eye infections was accomplished using 16s and internal transcribed spacer (its) ribosomal rna gene sequence analysis. pcr was positive for 24 of 99 samples tested. both culture and 16s rdna sequence analysis identified pseudomonas aeruginosa, streptococci and enterobacteriaceae. isolates misidentified as burkholderia cepacia by biochemical tes ... | 2011 | 21521414 |
| identification of strain harboring both aac(6')-ib and aac(6')-ib-cr variant simultaneously in escherichia coli and klebsiella pneumoniae. | the aac(6')-ib gene is the most prevalent gene that encodes aminoglycoside-modifying enzymes and confers resistance to tobramycin, kanamycin, and amikacin. the aac(6')-ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously. two main methods, sequence analysis and the restriction enzyme method, can detect the aac(6')-ib-cr variant in clinical strains. we collected the 85 strains that were believed to be aac(6')-ib positive from clinical isolates. among ... | 2011 | 21524352 |
| assessment of an extraction protocol to detect the major mastitis-causing pathogens in bovine milk. | despite all efforts to control its spread, mastitis remains the most costly disease for dairy farmers worldwide. one key component of better control of this disease is identification of the causative bacterial agent during udder infections in cows. mastitis is complex, however, given the diversity of pathogens that must be identified. development of a rapid and efficient bacterial species identification tool is thus necessary. this study was conducted to demonstrate the feasibility of bacterial ... | 2011 | 21524507 |
| clinical and microbiological analysis of adult perianal abscess. | in taiwan, klebsiella pneumoniae is the predominant pathogen causing pyogenic liver abscess in patients with diabetes mellitus (dm). the purpose of our hospital-based study was to determine the predominant bacterial species causing perianal abscess in hospitalized patients with and without dm in taiwan. | 2011 | 21524615 |
| clinical manifestations and prognostic factors in cancer patients with bacteremia due to extended-spectrum β-lactamase-producing escherichia coli or klebsiella pneumoniae. | background: clinical information about bacteremia due to extended-spectrum β-lactamase (esbl)-producing pathogens in cancer patients was limited. the study was aimed to identify the clinical manifestations and risk factors for mortality in esbl-producer bacteremia in cancer patients. methods: a retrospective study of bacteremia caused by esbl-producing escherichia coli or klebsiella pneumoniae in adults with cancer in national cheng kung university hospital and national taiwan university hospita ... | 2011 | 21524962 |
| antimicrobial susceptibilities of urinary extended-spectrum beta-lactamase-producing escherichia coli and klebsiella pneumoniae to fosfomycin and nitrofurantoin in a teaching hospital in taiwan. | background: urinary tract infections (utis) caused by extended-spectrum β-lactamase (esbl)-producing escherichia coli and klebsiella pneumoniae have become clinical problems because of limited therapeutic options. the role of fosfomycin in the era of growing bacteria resistance has been widely discussed recently. in this study, we aimed to know the local antimicrobial susceptibilities, fosfomycin susceptibility in particular, of urinary esbl-producing ecoli and kpneumoniae isolates in taiwan. me ... | 2011 | 21524974 |
| microbial isolation and emergence of antimicrobial resistance associated with tigecycline usage. | background: with the increasing experience of tigecycline usage, its ecological impact on microorganisms raises concerns but remains unknown. we aimed to analyze the difference in microorganisms isolated before, during, and after tigecycline usage and their susceptibility to antimicrobial agents. methods: between july 2008 and august 2009, 66 patients who received tigecycline monotherapy for more than 2 days at a taiwan medical center were enrolled. antimicrobial susceptibility testing was perfo ... | 2011 | 21524975 |
| antimicrobial susceptibility of bacteremic isolates from cancer patients with or without neutropenia at a medical center in southern taiwan. | background: few studies focus on comparison of antimicrobial susceptibility for bacteremic isolates in neutropenic and nonneutropenic cancer patients. the purpose of this study was to elucidate the antimicrobial susceptibility of bacteremic isolates from cancer patients. methods: we collected bacterial isolates causing bloodstream infections in cancer patients at a tertiary care hospital from 2003 to 2005 and performed in vitro antimicrobial susceptibility of these pathogens by the disc diffusio ... | 2011 | 21524977 |
| impact of age on neutrophil phagocytic reaction with different capsular serotypes of klebsiella pneumoniae. | background: although the prevalence of k pneumoniae liver abscess is higher in patients older than 55 years, the possible relationship of age with decreased phagocytic function of the patients with klebsiellapneumoniae liver abscess has not been investigated. our aim was to determine whether susceptibility to k pneumoniae infection depended on age-related impairment of phagocytic function. methods: the study enrolled 42 subjects in three age groups: younger than 40 years (n=10), 40-65 years (n=1 ... | 2011 | 21524978 |
| assessment of microbial contamination of toothbrush head: an in vitro study. | background: the most common oral hygiene aid used to improve the oral health of an individual is toothbrush and it is often neglected to maintain in a proper aseptic condition, which could probably result in contamination by various micro-organisms. aims: 1) to assess the microbial contamination of the hard deposit on the toothbrush head, between the bristle tufts, after 1 and 3 months of use. 2) to assess the microbial contamination of the hard deposit on the toothbrush head, between the bristl ... | 2011 | 21525668 |
| the inhibitory effect of zingiber corallinum hance essential oil on drug-resistant bacteria and evaluation of its acute toxicity. | background: the excessive and irregular use of antibiotics could result in the generation and diffusion of drug-resistant bacteria. the aim of this study was to investigate the inhibitory effect of zingiber corallinum hance essential oil (zcho) on drug-resistant bacteria, especially on drug-resistant acinetobacter baumannii.<br /> material/methods: susceptibility testing was used to evaluate the effect of zcho on growth inhibition of drug-resistant bacteria by paper disk method. mice orally admi ... | 2011 | 21525802 |
| phenotypic detection of broad-spectrum beta-lactamases in microbiological practice. | background: enterobacteriaceae producing esbl and ampc enzymes can be associated with failure of antibiotic therapy and related morbidity and mortality. their routine detection in microbiology laboratories is still a problem. the aim of this study was to compare the sensitivity of selected phenotypic methods.<br /> material/methods: a total of 106 strains of the enterobacteriaceae family were tested, in which molecular biology methods confirmed the presence of genes encoding esbl or ampc. in esb ... | 2011 | 21525803 |
| a call for action: the application of the international health regulations to the global threat of antimicrobial resistance. | stephen harbarth and colleagues argue that the international health regulations (ihr) should be applied to the global health threat of antimicrobial resistance. | 2011 | 21526227 |
| [outbreak of multiresistant and extended spectrum β-lactamase producing klebsiella pneumoniae in a high risk neonatal unit]. | klebsiella pneumoniae as a producer of extended spectrum beta-lactamase (esbl) has played an important role as a cause of infection in the neonatal high risk unit (nhru) of the autonomous hospital institute of the universidad de los andes (ahiula). in this paper an outbreak caused by this bacterial specie that affected neonates hospitalized in this unit during february 2007 is described. besides, the environment and the personnel were studied as possible sources of this organism. the strains of ... | 2011 | 21526282 |
| presence and distribution of fungi and bacteria in the reproductive tract of healthy stallions. | a saprophytic bacterial flora is present on the penis and the distal part of the urethra of stallions. little is known about the fungal flora of their reproductive tract. as micro organisms play an important role in mares fertility, the aim of the study was to describe the distribution of fungi and bacteria in the normal genital apparatus of stallions. the microbic flora of the reproductive tract of 11 healthy, fertile stallions was evaluated, collecting samples from 5 different locations: ureth ... | 2011 | 21529914 |
| metallo-β-lactamases: a last frontier for β-lactams? | metallo-β-lactamases are resistance determinants of increasing clinical relevance in gram-negative bacteria. because of their broad range, potent carbapenemase activity and resistance to inhibitors, these enzymes can confer resistance to almost all β-lactams. since the 1990s, several metallo-β-lactamases encoded by mobile dna have emerged in important gram-negative pathogens (ie, in enterobacteriaceae, pseudomonas aeruginosa, and acinetobacter baumannii). some of these enzymes (eg, vim-1 and ndm ... | 2011 | 21530894 |
| clinical study concerning the relationship between community-acquired pneumonia and viral infection in northern thailand. | objective the etiological agents associated with community-acquired pneumonia (cap) in thailand have been studied extensively in bacterial pathogens, but not in viral pathogens. to clarify the association of viral pathogens with cap, we conducted a comprehensive study of viral and bacterial pathogens in patients with cap. methods we enrolled 119 hospitalized patients with cap in nakornping hospital, chiang mai, thailand between 2006 and 2008. the severity of pneumonia was classified and the risk ... | 2011 | 21532221 |
| endogenous klebsiella endophthalmitis associated with liver abscess: first case report from iran. | to report the first case of endogenous klebsiella endophthalmitis associated with liver abscess in iran. | 2011 | 21532995 |
| optimal phenotypic testing of ampc beta-lactamases using boronic acid solutions. | plasmid-mediated class c β-lactamases are reported from escherichia coli and klebsiella pneumoniae with increasing frequency. no screening and confirmatory tests have been uniformly established for these strains. we investigated for the presence of plasmid-mediated ampc production in 51 clinical isolates of enterobacteriaceae, comparing two different boronic acid formulations, phenylboronic acid (pb) and 3-(n-boc-amino)phenylboronic acid (apb), using polymerase chain reaction (pcr). pb performed ... | 2011 | 21533876 |
| conformational change upon product binding to klebsiella pneumoniae udp-glucose dehydrogenase: a possible inhibition mechanism for the key enzyme in polymyxin resistance. | cationic modification of lipid a with 4-amino-4-deoxy-l-arabinopyranose (l-ara4n) allows the pathogen klebsiella pneumoniae to resist the antibiotic polymyxin and other cationic antimicrobial peptides. udp-glucose dehydrogenase (ugd) catalyzes the nad(+)-dependent twofold oxidation of udp-glucose (upg) to produce udp-glucuronic acid (uga), a requisite precursor in the biosynthesis of l-ara4n and bacterial exopolysaccharides. here we report five crystal structures of k. pneumoniae ugd (kpugd) in ... | 2011 | 21536136 |
| the identification of new metallo-β-lactamase inhibitor leads from fragment-based screening. | the emergence of metallo-β-lactamases (mbls) capable of hydrolysing a broad spectrum of β-lactam antibiotics is particularly concerning for the future treatment of bacterial infections. this work describes the discovery of lead compounds for the development of new inhibitors using a competitive colorimetric assay based on the chromogenic cephalosporin centa, and a 500 compound maybridge™ library suitable for fragment-based screening. the interactions between identified inhibitory fragments and t ... | 2011 | 21536436 |
| a promising target for treatment of multidrug-resistant bacterial infections. | multidrug-resistant infections pose a major quandary for clinicians by complicating therapy choice, compromising patient recovery and creating a serious threat to public health.… | 2011 | 21537011 |
| identifying patients harboring esbl-producing enterobacteriaceae on hospital admission: derivation and validation of a scoring system. | increases in community-acquired infections caused by extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae have important implications for hospital infection control and empirical antibiotic therapy protocols. we developed and validated a tool for identifying patients harboring these organisms at hospital admission. we retrospectively analyzed chart data for 849 adult inpatients. the derivation cohort included 339 patients admitted to a large rome hospital during 2008, with (n=113) o ... | 2011 | 21537020 |
| antimicrobial resistance in urinary tract pathogens in canada from 2007 to 2009: canward surveillance study. | from january 2007 to december 2009 an annual canadian national surveillance study (canward) tested 2943 urinary culture pathogens for antimicrobial susceptibilities following clinical and laboratory standards institute (clsi) guidelines. the most frequently isolated urinary pathogens (n, % of all isolates) were escherichia coli (1581, 54%), enterococci (410, 14%), klebsiella pneumoniae (274, 9%), proteus mirabilis (122, 4%), pseudomonas aeruginosa (100, 3%), and staphylococcus aureus (80, 3%). r ... | 2011 | 21537027 |
| in vitro antimicrobial efficacy of a silver alginate dressing on burn wound isolates. | to test the antimicrobial effectiveness of a silver alginate dressing on opportunistic pathogens, namely meticillin-sensitive staphylococcus aureus (mssa) and meticillin-resistant staphylococcus aureus (mrsa), klebsiella spp., enterococcus faecalis, enterococcus faecium, pseudomonas aeruginosa, escherichia coli, enterobacter sakazakii, enterobacter cloacae, serratia marcescens, chryseobacterium indologenes, proteus vulgaris and acinetobacter baumannii. | 2011 | 21537295 |
| chronic organizing retroperitoneal abscess caused by klebsiella oxytoca masquerading as sarcoma: recognition by diff-quik stain on fna material. | 2011 | 21538961 | |
| nosocomial klebsiella pneumoniae bacteraemia in adult cancer patients-characteristics of neutropenic and non-neutropenic patients. | abstract background: neoplastic diseases are common in patients with nosocomial klebsiella pneumoniae bacteraemia. this study investigated the clinical characteristics of neutropenic and non-neutropenic adult cancer patients with nosocomial k. pneumoniae bacteraemia. methods: adult cancer patients with k. pneumoniae bacteraemia were retrospectively analyzed at a medical centre in northern taiwan over a 3-y period. we compared clinical characteristics of cancer patients with nosocomial k. pneumon ... | 2011 | 21539500 |
| surgical treatment of 26 patients with necrotizing pneumonia. | background: this study aimed to review the outcome of patients treated with surgical resection for necrotizing lung infection with various co-morbidities and complications. methods: the records of 26 patients treated with pulmonary resection for necrotizing pneumonia between july 2004 and january 2010 were retrospectively reviewed. surgical procedures included large wedge resection (n = 1), lobectomy (n = 19) and bilobectomy (n = 6). results: the study cohort consisted of 21 men and 5 women aged ... | 2011 | 21540614 |
| synthesis and antimicrobial activities of hexahydroimidazo[1,5-a]pyridinium bromides with varying benzyl substituents. | variously substituted benzyl bromides were employed to quaternize hexahydrobenzylimidazo[1,5-a]pyridine (a) and the resulting bromides (1-11) were evaluated for their in vitro antimicrobial activity against 10 pathogenic microorganisms: staphylococcus aureus, staphylococcus epidermidis, bacillus cereus, micrococcus luteus, proteus vulgaris, escherichia coli, salmonella typhimurium, klebsiella pneumonia, candida albicans and candida krusei. antimicrobial activities were surprisingly high (mic: 0. ... | 2011 | 21543140 |
| an update of the evolving epidemic of blakpc-2-carrying klebsiella pneumoniae in greece (2009-10). | objectives to follow the epidemic of kpc-2-producing klebsiella pneumoniae in greece. methods kpc-2-producing isolates (n = 378) were collected during january 2009-april 2010 in 40 greek hospitals. bla(kpc) and bla(vim) were detected by pcr. carbapenemase production was confirmed by spectrophotometry. sequences flanking bla(kpc-2) and their plasmid carriers were studied. isolates were typed by pfge and multilocus sequence typing (mlst). results all 378 isolates were bla(kpc-2) positive; 18 also ... | 2011 | 21543359 |
| clinical features of healthcare-associated pneumonia (hcap) in a japanese community hospital: comparisons among nursing home-acquired pneumonia (nhap), hcap other than nhap, and community-acquired pneumonia. | summary at a glance: there were differences in bacteriological findings and mortality rates among subgroups of japanese patients with healthcare-associated pneumonia (hcap). the hcap guidelines of the american thoracic society/infectious diseases society of america may not necessarily be applicable for accurate diagnosis and optimum treatment of all japanese patients with hcap. abstract: background and objective: more than 100,000 japanese die of pneumonia every year. the number of people resid ... | 2011 | 21545370 |
| in vitro elution of amikacin and ticarcillin from a resorbable, self-setting, fiber reinforced calcium phosphate cement. | objective: to determine in vitro elution characteristics of amikacin and ticarcillin from fiber reinforced calcium phosphate beads (frcp). sample population: experimental. methods: frcp beads with water (a), amikacin (b), ticarcillin/clavulanate (c), or both amikacin and ticarcillin/clavulanate (d) were bathed in ml phosphate-buffered saline (pbs) at 37°c, 5% co(2) and 95% room air. pbs was sampled (eluent) and beads were placed in fresh pbs at time points 1 and 8 hours and 1, 2, 3, 4, 5, 6, 7, ... | 2011 | 21545461 |
| characterization of esbl-producing escherichia coli and klebsiella pneumoniae isolates from community in morocco. | of 803 community escherichia coli (n=767) and klebsiella pneumoniae (n=36) isolates collected from patients with urinary tract infections in three moroccan cities, 10 e.coli (1.3%) and 2 k. pneumoniae (5.5%) isolates were shown to produce extended-spectrum beta-lactamases. pulsed-field gel electrophoresis revealed that e.coli isolates comprised 7 distinct genotypes. the presence of plasmids in the 12 isolates was revealed by conjugation experiments of plasmids from these enterobacteriaceae strai ... | 2011 | 21546559 |
| disinfection of bacterial biofilms in pilot-scale cooling tower systems. | the impact of continuous chlorination and periodic glutaraldehyde treatment on planktonic and biofilm microbial communities was evaluated in pilot-scale cooling towers operated continuously for 3 months. the system was operated at a flow rate of 10,080 l day(-1). experiments were performed with a well-defined microbial consortium containing three heterotrophic bacteria: pseudomonas aeruginosa, klebsiella pneumoniae and flavobacterium sp. the persistence of each species was monitored in the recir ... | 2011 | 21547755 |
| production and properties of two collagenases from bacteria and their application for collagen extraction. | two collagenolytic protease (collagenase) producing bacteria, a gram positive bacillus cereus cna1 and a gram negative klebsiella pneumoniae cnl3, were isolated under alkaline and acidic conditions, respectively. the production of collagenase by these two bacteria was optimized. glycerol was the suitable carbon source for collagenase production by both strains. the optimal initial ph values for collagenase production by cna1 and cnl3 were 7.5 and 6.0, respectively, and the optimal temperature wa ... | 2011 | 21549225 |
| improved detection of ampc β-lactamases in escherichia coli, klebsiella pneumoniae, and proteus mirabilis using new susceptibility breakpoints for third-generation cephalosporins. | 2011 | 21549542 | |
| empyema thoracis: analysis of 150 cases from a tertiary care centre in north east india. | objectives: to analyze the clinical characteristics, microbiological profile, management, complications and outcome of cases with empyema thoracis. methods: all cases diagnosed as 'empyema thoracis' over a period from january 2006 through june 2010 were identified from the inpatient records and discharge summaries. of the 160 cases identified, 150 cases were taken up for analysis and the rest 10 cases, of which two had significant predisposing co-morbidity and eight cases diagnosed as tubercular ... | 2011 | 21553207 |
| emergence of four cases of kpc-2 and kpc-3-carrying klebsiella pneumoniae introduced to switzerland, 2009-10. | we report four epidemiologically unrelated cases of kpc-carrying klebsiella pneumoniae identified in switzerland between may 2009 and november 2010. three cases were transferred from italy (two kpc-3, one kpc-2) and one from greece (kpc-2). resistance to colistin and doxycycline emerged in one kpc-3-carrying k. pneumoniae strain during therapy. these results demonstrate ongoing dissemination of kpc throughout europe. rapid and reliable identification of kpc and implementation of control measures ... | 2011 | 21435328 |
| correlation between antibiotic consumption and resistance of gram-negative bacteria causing healthcare-associated infections at a university hospital in taiwan from 2000 to 2009. | this study investigated the correlation between antibiotic consumption and antimicrobial resistance in gram-negative bacteria causing healthcare-associated infections at a university hospital in taiwan from 2000 to 2009. | 2011 | 21436153 |
| effect of enhanced ultraviolet germicidal irradiation in the heating ventilation and air conditioning system on ventilator-associated pneumonia in a neonatal intensive care unit. | objective:the objective of this study was to test the hypothesis that enhanced ultraviolet germicidal irradiation (euvgi) installed in our neonatal intensive care unit (nicu) heating ventilation and air conditioning system (hvac) would decrease hvac and nicu environment microbes, tracheal colonization and ventilator-associated pneumonia (vap).studydesign:the study was designed as a prospective interventional pre- and post-single-center study. university-affiliated regional perinatal center nicu. ... | 2011 | 21436785 |
| emergence of ndm-1-positive capsulated escherichia coli with high resistance to serum killing in japan. | the new delhi metallo-+¦-lactamase-1 (ndm-1) gene, bla (ndm-1), is an emerging plasmid-borne drug resistance gene, which encodes for exceptionally broad-spectrum +¦-lactamase, being able to hydrolyze a wide variety of +¦-lactams, including carbapenems, and was first reported in klebsiella pneumoniae from a swedish patient of indian origin in 2009. it is widely distributed among enterobacteriacae and has geographically exhibited extremely rapid and global spread. in this study, we characterized t ... | 2011 | 21437680 |
| evolution of +¦-lactams resistance in gram-negative bacteria in tunisia. | antimicrobial resistance is a major health problem worldwide, but marked variations in the resistance profiles of bacterial pathogens are found between countries and in different patient settings. in tunisia, the strikingly high prevalence of resistance of bacteria to penicillins and cephalorosporins drugs including fourth generation in clinical isolates of gram negative bacteria has been reported. during 30 years, the emerging problem of extended-spectrum +¦-lactamase-producing escherichia coli ... | 2011 | 21438848 |
| changing trends in antimicrobial resistance of major bacterial pathogens, 1985-2005: a study from a medical center in northern taiwan. | antimicrobial resistance is a major health problem worldwide. we evaluated the antimicrobial resistance trends of 16 major bacterial pathogens at a tertiary medical center in northern taiwan. | 2011 | 21439516 |
| diagnostic utility of flexible bronchoscopy in recipients of solid organ transplants. | solid organ transplant (sot) recipients are prone to develop pulmonary complications (pc) due to their immunocompromised state. flexible bronchoscopy (fb) is frequently performed to diagnose the nature of these complications. the aim of this study was to evaluate the diagnostic utility of fb in sot recipients with suspected pc. | 2011 | 21440756 |
| [cmy-2-type plasmid-mediated ampc ß-lactamases emerging in tucumán, argentina]. | in the last years, enterobacteriaceae such as klebsiella pneumoniae, proteus mirabilis and escherichia coli, have acquired resistance to third-generation cephalosporins (c3g) because of the presence of plasmid-mediated ampc ß-lactamases. the aim of this work was to detect plasmid ampc enzymes and to investigate the predominant types in our region. between march and july 2009, 733 consecutive isolates of enterobacteriaceae derived from hospitals and outpatient centers were studied. susceptibility ... | 2011 | 21491062 |
| intra- and inter-species spread of carbapenemase genes in a non-hospitalized patient. | the purpose of this study was to report intra- and inter-species spread of carbapenemase genes between gram negative rods isolated from a non-hospitalized patient with bacteremia. the approach included chart review, antibiotic susceptibility testing and phenotypic screening for metallo-β-lactamase (mbl) detection, pcr and sequencing of bla, aac(6')-ib and qnr genes, and plasmid analysis by pcr-based replicon typing. the clonal relationships between the isolates were analysed by comparing pfge pr ... | 2011 | 21491175 |
| molecular and phenotypic characterization of escherichia coli and klebsiella pneumoniae producing extended-spectrum β-lactamases with focus on ctx-m in a low-endemic area in sweden. | during the last decade increasing prevalence of extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae has been detected worldwide, mainly due to dissemination of escherichia coli and klebsiella pneumoniae producing ctx-m-type esbls. ctx-m-15 is the most widespread ctx-m type, and the predominant type in various countries. dissemination of esbl-producing organisms is caused not only by horizontal transfer of plasmids, but also by clonal spread of esbl-producing strains. in this study, ... | 2011 | 21492229 |
| b lymphocyte subsets in patients with rhinoscleroma. | objective. to identify the presence of b lymphocytes in the rhinoscleroma granulomas as a possible precursor of plasma cells, whose presence has always been described but whose role is still unclear. study design. case series with chart review. setting. sapienza university of rome. methods. the study was carried out on 6 patients (3 women, 3 men). the following parameters were examined for each patient: clinical manifestations, number of leukocytes, lymphocytes and lymphocyte subsets (cd3+, cd4+ ... | 2011 | 21493362 |
| outbreak of klebsiella oxytoca enterocolitis on a rabbit farm in hungary. | 2011 | 21493575 | |
| crystal structure of the branching enzyme i (bei) from oryza sativa l with implications for catalysis and substrate binding. | starch branching enzyme (sbe) catalyzes the cleavage of α-1,4-linkages and the subsequent transfer of α-1,4 glucan to form an α-1,6 branch point in amylopectin. sequence analysis of the rice branching enzyme i (bei) indicated a modular structure in which the central α-amylase domain is flanked on each side by the n-terminal carbohydrate binding module (cbm48) and the α-amylase c-domain. we determined the crystal structure of bei at a resolution of 1.9 å by molecular replacement using the escheri ... | 2011 | 21493662 |
| ultra-fast and sensitive detection of non-typhoidal salmonella using microwave-accelerated metal-enhanced fluorescence ("mamef"). | certain serovars of salmonella enterica subsp. enterica cause invasive disease (e.g., enteric fever, bacteremia, septicemia, meningitis, etc.) in humans and constitute a global public health problem. a rapid, sensitive diagnostic test is needed to allow prompt initiation of therapy in individual patients and for measuring disease burden at the population level. an innovative and promising new rapid diagnostic technique is microwave-accelerated metal-enhanced fluorescence (mamef). we have adapted ... | 2011 | 21494634 |
| the enemy within. | 2011 | 21495481 | |
| risk factors and pathogen profile of ventilator-associated pneumonia in a neonatal intensive care unit in china. | aim: the aim of this study is to explore the incidence, risk factors and summarize the involved pathogens among neonates with vap in our nicu to determine the effective strategies for prevention. methods: a retrospective case-control study including 117 cases of vap and 232 cases of control was conducted from january 2002 to july 2008. the antibiotics sensitivity spectrum was determined by quantitative microbiological evaluation. multiple logistic regression and cox model analysis was performed ... | 2011 | 21496177 |
| real-time pcr assay allows detection of the new delhi metallo-β-lactamase (ndm-1)-encoding gene in france. | in this study, we report the development of a rapid real-time polymerase chain reaction (pcr) assay with taqman(®) probe to detect the new delhi metallo-β-lactamase (ndm-1)-encoding gene directly from bacterial isolates. the specificity of the assay was verified in silico as well as with a large panel of 84 clinically relevant bacteria, including the klebsiella pneumoniae nctc 13443 ndm-1-positive reference strain. using this assay retrospectively on a local series of 44 k. pneumoniae isolates f ... | 2011 | 21497063 |
| impact of previous antibiotic therapy on outcome of gram-negative severe sepsis. | objective:: to determine whether exposure to antimicrobial agents in the previous 90 days resulted in decreased bacterial susceptibility and increased hospital mortality in patients with severe sepsis or septic shock attributed to gram-negative bacteremia. design:: a retrospective cohort study of hospitalized patients (january 2002 to december 2007). setting:: barnes-jewish hospital, a 1200-bed urban teaching hospital. patients:: seven hundred fifty-four consecutive patients with gram-negative b ... | 2011 | 21499086 |
| risk factors for endogenous endophthalmitis secondary to klebsiella pneumoniae liver abscess: 20-year experience in southern taiwan. | purpose:: to identify the risk factors for endogenous endophthalmitis secondary to klebsiella pneumoniae liver abscess. methods:: we conducted a retrospective review of medical records of 602 patients admitted with k. pneumoniae liver abscess from january 1991 to november 2009. variables included age, sex, history, month of onset, systemic condition, initial and final visual acuities, slit-lamp biomicroscopy, intraocular pressure, fundus, course and treatment. results:: endophthalmitis was ident ... | 2011 | 21499189 |
| roles of pseudomonas aeruginosa autoinducers and their degradation products, tetramic acids, in bacterial survival and behavior in ecological niches. | pseudomonas aeruginosa, an opportunistic pathogen, is known to mainly use n-acylhomoserine lactones (ahls) as autoinducers. recent progress in this field demonstrated that not only ahls, but also their degradation products, tetramic acids, may have some biological activities. the present study examined the roles of pseudomonas autoinducers and tetramic acids in bacterial survival and behavior in ecological niches. p. aeruginosa autoinducers and the tetramic acid derivatives were chemically synth ... | 2011 | 21502732 |
| antibiotic susceptibility and imaging findings of the causative microorganisms responsible for acute urinary tract infection in children: a five-year single center study. | we studied the differences in the antibiotic susceptibilities of the microorganisms that causeing urinary tract infections (uti) in children to obtain useful information on appropriate drug selection for childhood uti. | 2011 | 21503201 |
| nosocomial and community infections due to class a extended-spectrum β-lactamase (esbla)-producing escherichia coli and klebsiella spp. in southern brazil. | to determine the prevalence of class a extended spectrum β-lactamases (esbl)-producing escherichia coli and klebsiella spp., and to investigate clonality among esbl-producing isolates of nosocomial and community infections. | 2011 | 21503400 |
| identification of putative new escherichia coli flagellar antigens from human origin using serology, pcr-rflp and dna sequencing methods. | escherichia coli has been isolated frequently, showing flagellar antigens that are not recognized by any of the 53 antisera, provided by the most important reference center of e. coli, the international escherichia and klebsiella center (who) of the statens serum institute, copenhagen, denmark. the objective of this study was to characterize flagellar antigens of e. coli that express non-typeable h antigens. the methods used were serology, pcr-rflp and dna sequencing. this characterization was p ... | 2011 | 21503401 |
| sitafloxacin: in bacterial infections. | sitafloxacin is a fluoroquinolone antibacterial with in vitro activity against a broad range of gram-positive and -negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. it is approved in japan for use in a number of bacterial infections caused by sitafloxacin-susceptible strains of staphylococcus spp., streptococcus pneumoniae, other streptococcus spp., enterococcus spp., moraxella catarrhalis, escherichia coli, citrobacter spp., klebsiella spp., enterobacter sp ... | 2011 | 21504249 |
| bile bacterial flora and its in vitro resistance pattern in patients with acute cholangitis resulting from choledocholithiasis. | abstract introduction. cholangitis and biliary sepsis are severe infectious diseases, which are often observed in patients with choledocholithiasis. the antimicrobial therapy is effective if started as soon as the diagnosis is made. therefore, the profile of bile pathogens and its susceptibility to a number of antibiotics were evaluated. material and methods. bile cultures and antibiograms from 92 patients hospitalized between january 2006 and december 2008 in a tertiary referral center for the ... | 2011 | 21504380 |
| [effect of jinqiaomai on expression of tlr2/4, myd88 mrna and ikappab-alpha in lung tissue of rats with klebsiella pneumonia]. | to study the mechanism of protective effect of jinqiaomai (jqm) on lung injury induced by klebsiella pneumonia in rats. | 2011 | 21506423 |
| bacterial contamination of the hands of doctors: a study in the medicine and dermatology wards. | background: doctors' hands are a common source of bacterial contamination. often, these organisms are found to be virulent species with multidrug-resistance patterns. these are the sources of nosocomial infections in many patients. aims: the present study was undertaken to find out the prevalence of bacterial contamination in the hands of doctors in the medicine and dermatology wards of a tertiary care hospital. methods: the hands of 44 doctors were swabbed and cultured at entry to ward and at e ... | 2011 | 21508569 |
| de-escalation of antimicrobials in the treatment of bacteraemia due to antibiotic-sensitive pathogens in immunocompetent patients. | background: the aim of this study was to examine the safety and efficacy of de-escalating antimicrobial therapy in immunocompetent patients presenting with bacteraemia due to antibiotic-sensitive pathogens. methods: we screened 1,350 positive blood cultures identified in a single, 1,065-bed university hospital over 5 years, and retained 310 cases of bacteraemia due to antibiotic-sensitive pathogens, including (1) methicillin-sensitive staphylococci, (2) penicillin-sensitive streptococci, (3) β-l ... | 2011 | 21509424 |
| cefotaxime resistance and outcome of klebsiella spp bloodstream infection. | we attempt to describe the epidemiology and outcome associated with cefotaxime-resistant (ctx-r) klebsiella spp bacteraemia. klebsiella spp bloodstream infection episodes prospectively collected through a blood culture surveillance programme from january 1991 to december 2008 in a single institution were analysed. a total of 910 monomicrobial episodes of klebsiella spp bacteraemia were identified during the study period. the most important sources were from urinary tract infection, unknown sourc ... | 2011 | 21509474 |
| antibiotic activity of tigecycline against clinical pathogens by the micro dilution method. | resistant pathogens are the cause of clinical infections which threatening the patients lives and challenging the health systems through their economic importance. therefore, new antibacterial agents with a broader spectrum of activity that protect against development of resistance are required. tigecycline (tygacil, wyeth) is a relatively new fda and emea approved glycylcycline antimicrobial with an expanded broad-spectrum activity against pathogens involved in complicated skin and skin structu ... | 2011 | 21513809 |
| in vitro activity of cxa-101 plus tazobactam (cxa-201) against ctx-m-14- and ctx-m-15-producing escherichia coli and klebsiella pneumoniae. | cxa-101, a novel cephalosporin with good antipseudomonal activity, was evaluated against a consecutive and polyclonal collection of extended-spectrum-β-lactamase (esbl)-producing escherichia coli (n = 149) and klebsiella pneumoniae (n = 20), mainly ctx-m-15- (69%) or ctx-m-14 producing (22%). a total of 41% of the e. coli isolates belonged to the international clone o25b-st131. broth microdilution versus cxa-101, cxa-tazobactam 4 and 8 mg/l (cxa-201), ceftazidime-tazobactam (cat), ceftazidime-cl ... | 2011 | 21513849 |
| genetic regulation of the rama locus and its expression in clinical isolates of klebsiella pneumoniae. | tigecycline resistance has been attributed to rama overexpression and subsequent acra upregulation. the rama locus, originally identified in klebsiella pneumoniae, has homologues in enterobacter and salmonella spp. in this study, we identify in silico that the ramr binding site is also present in citrobacter spp. and that enterobacter, citrobacter and klebsiella spp. share key regulatory elements in the control of the roma-rama locus. race (rapid amplification of cdna ends) mapping indicated tha ... | 2011 | 21514798 |
| dissemination in the community of clinical isolates of klebsiella oxytoca harboring cmy-31, vim-1 and a new oxy-2 type variant. | the aim of the present study was to investigate the epidemiological link of multidrug-resistant klebsiella oxytoca isolates causing community-onset infections among patients attending our outpatient department and to investigate the underlying resistance mechanisms. the isolates were tested by agar dilution mics, phenotypic carbapenemase testing, eric-pcr and pfge. pcr assays and nucleotide sequencing were employed for identification of bla gene types and mapping of the integron containing metal ... | 2011 | 21555768 |
| risk factors for infection and treatment outcome of extended-spectrum β-lactamase-producing escherichia coli and klebsiella pneumoniae bacteremia in patients with hematologic malignancy. | this study was performed to evaluate the impact of extended-spectrum β-lactamase (esbl)-producing bacteremia on outcome in patients with hematologic malignancy. we collected and analyzed data on 156 hematologic malignancy patients with escherichia coli or klebsiella pneumoniae bacteremia from the database of nationwide surveillance studies for bacteremia. thirty-seven of the 156 patients (23.7%) harbored esbl-producing bacteremia. no significant differences in underlying diseases were found in e ... | 2011 | 21556875 |
| community and nursing home residents with carbapenemase-producing klebsiella pneumoniae infection. | 2011 | 21558781 | |
| [the distributions and spreads of antimicrobial drug-resistant microorganisms in saga prefecture]. | we investigated the distribution of drug-resistant organisms to clarify transmission of the organisms. drug-resistant organisms were surveyed in 12 facilities in 4 districts of saga prefecture for 2 years, and were analyzed by beta-lactamase typing, antimicrobial susceptibility tests and pulsed-field gel electrophoresis (pfge). the number of isolates was 111,505 for the 2 years. questionnaires for drug-resistant organisms revealed that methicillin-resistant staphylococcus aureus (mrsa) was 64.1% ... | 2011 | 21560403 |
| diverse phenotypic and genotypic characterization among clinical klebsiella pneumoniae and escherichia coli isolates carrying plasmid-mediated quinolone resistance determinants. | a total of 59 and 74 nonduplicate plasmid-mediated quinolone resistance (pmqr) genes-carrying klebsiella pneumoniae and escherichia coli isolates were collected. all strains were assayed for fluoroquinolone susceptibility and the prevalence of quinolone resistance-determining regions (qrdrs) mutation. the association between pmqr determinants and common β-lactamase genes was also analyzed. genetic relatedness of the isolates was analyzed by pulsed-field gel electrophoresis (pfge). the pmqr genes ... | 2011 | 21563956 |
| spread of klebsiella pneumoniae isolates producing oxa-48 {beta}-lactamase in a tunisian university hospital. | 2011 | 21565807 | |
| [trends of causative and antimicrobial resistant organisms among patients with hematological malignancies in japan]. | 2011 | 21566402 | |
| klebsiella pneumoniae yersiniabactin predisposes to respiratory tract infection through evasion of lipocalin 2. | klebsiella pneumoniae is a pathogen of increasing concern because of multidrug-resistance, especially due to k. pneumoniae carbapenemases (kpc). k. pneumoniae must acquire iron to replicate, and utilizes iron scavenging siderophores such as enterobactin (ent). the innate immune protein lipocalin 2 (lcn2) is able to specifically bind ent and disrupt iron acquisition. to determine whether k. pneumoniae must produce lcn2-resistant siderophores to cause disease, we examined siderophore production by ... | 2011 | 21576334 |
| blakpc rna expression correlates with two transcriptional start sites but not always with gene copy number in four genera of gram-negative pathogens. | kpc producing organisms are therapeutically and diagnostically challenging. it is possible that bla(kpc) gene expression plays a role in the variability observed in clinical susceptibility testing. bla(kpc) transformants together with 10 clinical isolates representing four genera were evaluated for bla(kpc) copy number and gene expression and correlated with β-lactam mic data. the data suggest that mechanisms other than gene copy number and expression of bla(kpc) contribute to variability in sus ... | 2011 | 21576436 |
| dissemination of blakpc-2 by the spread of cc258-klebsiella pneumoniae clones (st258, st11, st437) and plasmids (incfii, incn, incl/m) among enterobacteriaceae species in brazil. | this study reports the spread of bla(kpc-2) in são paulo and rio de janeiro states facilitated by globally spread cc258-k. pneumoniae clones (st258, st11, st437) and a diversity of plasmids (incfii, incn, incl/m, two untypeable plasmids carrying tn4401a or tn4401b) successfully disseminated among enterobacteriaceae species (enterobacter cloacae, serratia marcescens and citrobacter freundii). it also constitutes the first description of st258 in brazil which was associated with a nosocomial hospi ... | 2011 | 21576442 |
| susceptibility of gram-positive and -negative bacteria to novel nitric oxide-releasing nanoparticle technology. | the rapidly evolving crisis of antibiotic resistance among microorganisms has contributed to the rise of patient morbidity and mortality from nosocomial and community-acquired infections. therefore, innovative antimicrobial technology targeting mechanisms to which the bacteria are unlikely to evolve resistance is urgently needed. we have previously described a nitric oxide-releasing nanoparticle (no-np) with efficacy against methicillin-resistant staphylococcus aureus (mrsa) and acinetobacter ba ... | 2011 | 21577055 |
| plasminogen activator inhibitor type-1 deficiency exaggerates lps-induced acute lung injury through enhancing toll-like receptor 4 signaling pathway. | mice lacking plasminogen activator inhibitor-1 (pai-1) did not affect lung injury induced by gram-positive bacteria pneumococcal pneumonia but worsened lung injury induced by gram-negative bacteria klebsiella. the exact mechanisms have not been completely elucidated. in this study, we examined the signaling pathway of toll-like receptor 4 (tlr4) with/without pai-1 in acute lung injury (ali) induced by lipopolysaccharides (lps) in mice. pai-1 knockout mice (n = 60) and wild-type mice (n = 60) wer ... | 2011 | 21577093 |
| β-thymosin is upregulated by the steroid hormone 20-hydroxyecdysone and microorganisms. | thymosins have diverse biological activities including actin-sequestering and tissue repair in vertebrates, however, there is little information about the function of thymosins in invertebrates. we isolated a β-thymosin gene in helicoverpa armigera. it has two transcript variants, hathy1 and hathy2, encoding 19.0 kda and 14.5 kda peptides, respectively. hathy1 was mainly transcribed in the integument and midgut, while hathy2 was principally presented in the fat body and haemocytes. the transcrip ... | 2011 | 21585579 |
| predictors of mortality in patients with bloodstream infections caused by kpc-producing klebsiella pneumoniae and impact of appropriate antimicrobial treatment. | clin microbiol infect abstract: bloodstream infections (bsis) caused by klebsiella pneumoniae carbapenemases (kpc)-producing k. pneumoniae (kpc-kp) are associated with high mortality rates. we investigated outcomes, risk factors for mortality and impact of appropriate antimicrobial treatment in patients with bsis caused by molecularly confirmed kpc-kp. all consecutive patients with kpc-kp bsis between may 2008 and may 2010 were included in the study and followed-up until their discharge or death ... | 2011 | 21595793 |
| molecular characterization of vim-producing klebsiella pneumoniae from scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance. | clin microbiol infect abstract: vim-producing klebsiella pneumoniae (vpkp) has been identified as a source of hospital outbreaks and is prevalent particularly in the mediterranean region. in this study we have characterized eight vpkp isolates identified in scandinavia during 2005-2008. with the exception of one isolate, all were from patients with recent history of hospitalization abroad (greece, n = 6; turkey, n = 1). multilocus sequence typing (mlst) resulted in five sequence types (sts), st3 ... | 2011 | 21595797 |
| a multiple antibiotic and serum resistant oligotrophic strain, klebsiella pneumoniae mb45 having novel dfra30, is sensitive to zno qds. | abstract: background: the aim of this study was to describe a novel trimethoprim resistance gene cassette, designated dfra30, within a class 1 integron in a facultatively oligotrophic, multiple antibiotic and human serum resistant test strain, mb45, in a population of oligotrophic bacteria isolated from the river mahananda; and to test the efficiency of surface bound acetate on zinc oxide quantum dots (zno qds) as bactericidal agent on mb45. methods: diluted luria broth/agar (10-3) media was use ... | 2011 | 21595893 |
| synergistic anti-bacterial and proteomic effects of epigallocatechin gallate on clinical isolates of imipenem-resistant klebsiella pneumoniae. | imipenem-resistant klebsiella pneumoniae (irkp) were used to explore the synergistic anti-bacterial and proteomic effects of imipenem alone or in combination with epigallocatechin gallate (egcg). the minimal inhibitory concentrations (mics) of egcg for 12 clinically isolated irkp strains ranged from 300 to 650μg/ml. each of the 12 irkp strains experienced a 4- to 64-fold reduction in the mic of imipenem upon co-incubation with 0.25×mic level of egcg. the time-kill method was used on the 12 irkp ... | 2011 | 21596543 |
| pharmacokinetics of free ertapenem in critically ill septic patients: intermittent versus continuous infusion. | background: the aim of this paper was to compare the pharmacokinetic and pharmacodynamic (pk/pd) parameters of continuous (ci) and intermittent infusion (iti) of ertapenem into critically ill patients with severe abdominal infections. methods: twenty septic patients hospitalized in a university hospital intensive care unit were enrolled in the study. half of the patients received ertapenem as an iti 1 g bolus once daily, and the other half of the patients received the same dose via ci over 24 h ... | 2011 | 21597443 |