Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| dysfunctional gastric emptying with down-regulation of muscle-specific micrornas in helicobacter pylori-infected mice. | little is known about the pathogenic mechanisms of functional dyspepsia. we investigated the role of micrornas (mirnas) in gastric motility disorders associated with helicobacter pylori infection. | 2011 | 20801118 |
| the expression of renin-angiotensin system components in the human gastric mucosa. | the aim of the present study was to map the distribution of representative protein components of the renin-angiotensin system (ras) in the human gastric mucosa. | 2011 | 20739374 |
| investigation of the association between helicobacter pylori infection and normal tension glaucoma. | to investigate whether helicobacter pylori infection is associated with normal tension glaucoma (ntg). | 2011 | 20811063 |
| effect of eradication of helicobacter pylori in children with chronic immune thrombocytopenia: a prospective, controlled, multicenter study. | the eradication of helicobacter pylori has been associated with remission of immune thrombocytopenia (itp) in approximately half of eradicated patients. data on children are limited to small case series. | 2011 | 20830773 |
| genetic diversity in strains of helicobacter pylori from india and their relatedness to strains from other parts of the world. | helicobacter pylori is predominantly transmitted within families and infection occurs mostly in early childhood, frequently leading to persistent infection lifelong. in the present study, genetic diversity of helicobacter pylori among north and south indian isolates was evaluated. 16s rdna, caga, vaca and icea genes were amplified followed by sequencing of respective amplicons for diversity analysis. result of pcr assay showed that status of pathogenicity genes varied among strains from varanasi ... | 2011 | 20833269 |
| frequent occurrence of gastritis and duodenitis in patients with inflammatory bowel disease. | the purpose was to study the epidemiology of helicobacter-negative gastritis among a large group of patients with inflammatory bowel disease (ibd) and healthy controls. | 2011 | 20848539 |
| conventional narrow-band imaging has good correlation with histopathological severity of helicobacter pylori gastritis. | narrow-band imaging (nbi) is an optical image enhancement technique that enhances the vessels and patterns of gastric mucosal surface. here we aim to test the diagnostic role of conventional nbi (c-nbi) in identifying helicobacter pylori (hp) infection, severity of gastritis, and gastric atrophy. | 2011 | 20857197 |
| eosinophil counts in upper digestive mucosa of western european children: variations with age, organs, symptoms, helicobacter pylori status, and pathological findings. | the aim of the study was to measure the number of eosinophils per high-power field (eos/hpf) according to age, organs, and clinical symptoms and to compare the results to histological characteristics of the upper digestive tract mucosa in children. | 2011 | 20890222 |
| immunoproteomics of helicobacter pylori infection in patients with atrophic body gastritis, a predisposing condition for gastric cancer. | atrophic body gastritis is considered an outcome of h. pylori infection at high risk for gastric cancer. immunoproteomics has been used to detect h. pylori antigens, which may act as potential markers for neoplastic disease and may be used in specific serological tests. we used immunoproteome technology to identify h. pylori antigens, recognized by sera from patients with atrophic body gastritis. here, we performed 2de protein maps of h. pylori strain 10k, probed against single sera from 3 group ... | 2011 | 20843738 |
| new insights into the distribution of wxg100 protein secretion systems. | protein secretion is an important aspect of bacterial interaction with the environment. the wxg100 secretion system is a poorly understood pathway for the secretion of members of the wxg100 protein family in firmicutes and actinobacteria, notably mycobacteria. this pathway has also been termed the type vii secretion system but there are semantic problems with this nomenclature. this perspective reviews the phylum level distribution of wxg100 secretion systems and presents comparative genomic evi ... | 2011 | 20852931 |
| membrane-associated activation of cholesterol α-glucosyltransferase, an enzyme responsible for biosynthesis of cholesteryl-α-d-glucopyranoside in helicobacter pylori critical for its survival. | helicobacter pylori (h. pylori) is the causative pathogen underlying gastric diseases such as chronic gastritis and gastric cancer. previously, the authors revealed that α1,4-linked n-acetylglucosamine-capped o-glycan (αglcnac) found in gland mucin suppresses h. pylori growth and motility by inhibiting catalytic activity of cholesterol α-glucosyltransferase (chlαgct), the enzyme responsible for biosynthesis of the major cell wall component cholesteryl-α-d-glucopyranoside (cgl). here, the authors ... | 2011 | 20876522 |
| stress controversies: post-traumatic stress disorder, hippocampal volume, gastroduodenal ulceration*. | stress in mammals triggers a neuroendocrine response mediated by the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. increased activity of these two systems induces behavioural, cardiovascular, endocrine and metabolic cascades that enable the individual to fight or flee and cope with the stress. our understanding of stress and stress-response mechanisms is generally robust. here, however, we review three themes that remain controversial and perhaps deserve further scrutiny ... | 2011 | 20973838 |
| population attributable fraction of infection-related cancers in korea. | a number of infectious agents have been classified as human carcinogens. the purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the korean population. materials and methods: the population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly korean studies and national data on cancer incidence and mortality for the year 2007. | 2011 | 20974652 |
| reviewed diagnosis of primary and secondary immune thrombocytopenic purpura in 79 adult patients hospitalized in 2000-2002. | despite the accepted distinction between primary and secondary immune thrombocytopenic purpura (itp), a systematic analysis of the incidence of secondary itp is not available. the present study was aimed at verifying the frequency and, consequently, the approximate rates of prevalence and incidence of secondary itp and analysing its clinical and laboratory characteristics in patients needing ordinary hospital treatment for itp. the study was based on 79 consecutive, adult itp patients admitted t ... | 2011 | 20962625 |
| association of helicobacter pylori infection with acute myocardial infarction. | helicobacter pylori infection has been linked to cardiovascular diseases (cvd) and several studies have reported its positive association with inflammatory response after acute myocardial infarction (ami). on account of the importance of the inflammatory process in the development of cvd, we decided to examine the seroprevalence of h. pylori, the prevalence of cvd risk in the more virulent strains bearing the cytotoxin-associated protein (caga), and the changes in c-reactive protein (crp) as an ... | 2011 | 20962628 |
| malnutrition, infection and arteriovenous fistula failure: is there a link? | the histology of neointimal hyperplasia, the primary cause of arteriovenous fistula (avf) stenosis, resembles the histology of atherosclerosis. we evaluated classic atherogenic risk factors such as hypertension, smoking, diabetes, cholesterol, and evaluated the role of expanded risk factors such as: cytomegalovirus (cmv), helicobacter pylori (h. pylori), chlamydia pneumoniae (c. pneumoniae), infection, and malnutrition, as possible causes of avf failure in hemodialysis (hd) patients. | 2011 | 21038306 |
| pathogenesis of igg4-related disease. | to review studies that have examined underlying genetic and immunological aspects of igg4-related disease. | 2011 | 21045701 |
| impact of helicobacter pylori caga diversity on gastric mucosal damage: an immunohistochemical study of east-asian-type caga. | recently, we successfully produced an anti-east-asian-type caga-specific antibody called α-eas ab, which is specifically immunoreactive only with east-asian-type caga but not western-type caga. in this study, the correlations between helicobacter pylori caga protein diversity and gastric mucosal condition was investigated using immunohistochemical staining with α-eas ab in japan. | 2011 | 21054521 |
| effect of helicobacter pylori infection on growth velocity of school-age andean children. | helicobacter pylori infection affects about half of the world's population and is usually acquired in childhood. the infection has been associated with chronic gastritis, peptic ulcer, and stomach cancer in adulthood. little is known, however, about its consequences on child health. we examined the effect of h. pylori infection on growth among school-age children in the colombian andes by comparing growth velocity in the presence and absence of h. pylori infection. | 2011 | 21068668 |
| a nucleotide insertion between two adjacent methyltransferases in helicobacter pylori results in a bifunctional dna methyltransferase. | helicobacter pylori has a dynamic r-m (restriction-modification) system. it is capable of acquiring new r-m systems from the environment in the form of dna released from other bacteria or other h. pylori strains. random mutations in r-m genes can result in non-functional r-m systems or r-m systems with new properties. hpyaviam and hpyavibm are two solitary dna mtase (methyltransferase) genes adjacent to each other and lacking a cognate restriction enzyme gene in h. pylori strain 26695. interesti ... | 2011 | 21110832 |
| infection, stem cells and cancer signals. | the association of cancer with preceding parasitic infections has been observed for over 200 years. some such cancers arise from infection of tissue stem cells by viruses with insertion of viral oncogenes into the host dna (mouse polyoma virus, mouse mammary tumor virus). in other cases the virus does not insert its dna into the host cells, but rather commandeers the metabolism of the infected cells, so that the cells continue to proliferate and do not differentiate (human papilloma virus and ce ... | 2011 | 21044009 |
| hepatic encephalopathy: from pathophysiology to therapeutic management. | hepatic encephalopathy is a complex and potentially reversible neuropsychiatric syndrome complicating acute or chronic liver disease. clinical manifestations are multiple and varied, ranging from minimal neurological changes to coma. ammonia is the main toxic substance involved in the pathogenesis of hepatic encephalopathy, although other mechanisms, such as modifications of the blood-brain barrier, disruptions in neurotransmission and abnormalities in gabaergic and benzodiazepine pathways may a ... | 2011 | 21099434 |
| efficacy of amifostine in treating patients with idiopathic thrombocytopenia purpura. | idiopathic thrombocytopenic purpura (itp) is an autoimmune disease characterized by the production of antibodies against platelet surface antigens, resulting in platelet destruction. itp is generally treated using glucocorticoids, splenectomy, immunosuppressants, platelet transfusions, and also rituxan and rituximab. however, as these treatments are not effective in some refractory itp patients, especially the elderly, who are also at greater risk of cerebral hemorrhage, we have undertaken this ... | 2011 | 21104159 |
| topographic differences in gastric micromucosal patterns observed by magnifying endoscopy with narrow band imaging. | the distributions and grades of helicobacter pylori induced gastritis are known to vary among h. pylori-associated diseases. the aim of this study was to investigate the differences in distributions of gastric micromucosal structures observed by magnifying narrow band imaging (nbi) endoscopy among patients with different h. pylori-associated diseases. | 2011 | 21155881 |
| is cardia cancer aetiologically different from distal stomach cancer? | the coexistence of two aetiologically distinct types of cardia cancer, with distinctive histological characteristics of the neoplastic and nonneoplastic gastric mucosa, may explain the heterogeneous evidence of its association with helicobacter pylori infection. we compared gastric cardia and noncardia cancers with regard to the frequency of h. pylori infection, the histological characteristics of the nonneoplastic gastric mucosa and the tumour histological type. we evaluated 41 cardia and 339 n ... | 2011 | 21150780 |
| retraction. activation of intercellular adhesion molecule 1 expression by helicobacter pylori is regulated by nf-κb in gastric epithelial cancer cells. | 2011 | 21177931 | |
| retraction. induction of monocyte chemoattractant protein 1 by helicobacter pylori involves nf-κb. | 2011 | 21177932 | |
| retraction. helicobacter pylori induces rantes through activation of nf-κb. | 2011 | 21177933 | |
| retraction. helicobacter pylori induces ccl20 expression. | 2011 | 21177934 | |
| retraction. helicobacter pylori-induced interleukin-12 p40 expression. | 2011 | 21177935 | |
| effects of multistrain probiotic-containing yogurt on second-line triple therapy for helicobacter pylori infection. | the adjuvant effects of probiotic-containing yogurt on second-line triple therapy for helicobacter pylori (h. pylori) infection have not been evaluated. | 2011 | 21175792 |
| correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study. | an algorithm (gastropanel) for the non-invasive diagnosis of atrophic gastritis has been previously proposed, based on serum pepsinogen-i, gastrin-17, and helicobacter pylori (h. pylori) antibodies. the aim of the present study was to evaluate whether serum markers correlate with and predict gastric atrophy in gastroesophageal reflux disease (gerd) patients. | 2011 | 21175799 |
| gastroesophageal reflux disease in asia: a historical perspective and present challenges. | gastroesophageal reflux disease (gerd), previously uncommon in asia, has now become an important disease in the region. although much variability exists between studies, most endoscopy-based studies show a prevalence of erosive esophagitis of more than 10%. symptom-based studies also show a prevalence of 6-10%. two longitudinal follow-up studies on gerd symptoms have shown an increase with time, and several endoscopy-based time trend studies have also shown a significant increase in erosive refl ... | 2011 | 21199509 |
| the ulcer sleuths: the search for the cause of peptic ulcers. | the search for the cause or causes of peptic ulcers has been a long one. it was recognised as early as the 19th century that damage to the stomach or duodenal bulb was likely to result if the resistance of their mucosae to luminal acid was for some reason impaired. an early theory suggested microscopic vascular occlusion leading to local infarction could be the initiating event but evidence was lacking. excessive acid secretion is seen in some patients but not in many so is implausible as the ma ... | 2011 | 21199512 |
| helicobacter pylori and gastritis: untangling a complex relationship 27 years on. | since its' introduction by warren and marshall 27 years ago, helicobacter pylori (hp) has become the linchpin in our understanding of important gastric conditions including gastritis, intestinal metaplasia (im), gastric/duodenal ulcers (gu/du), mucosal associated lymphoid tumour (maltoma) and gastric cancer. initially named campylobacter pyloridis, it was re-named hp when biochemical and genetic characterization of the organism showed that it was not a member of the campylobacter genus. the find ... | 2011 | 21199513 |
| fish oil exacerbates colitis in smad3 mice. | 2011 | 21199808 | |
| association between helicobacter pylori infection and pancreatic cancer. a cumulative meta-analysis. | infection with helicobacter pylori (h. pylori) has been implicated in the etiopathogenesis of various malignant conditions. notwithstanding, its etiological association with pancreatic cancer remains inconclusive. studies focusing on the relationship between h. pylori infection and pancreatic cancer risk have yielded conflicting results. | 2011 | 21206097 |
| helicobacter pylori and beta-2 microglobulin. | 2011 | 21206336 | |
| comparison of two different treatment protocols in helicobacter pylori eradication. | the prevalence of helicobacter pylori (h pylori) in turkey is high and eradication rates are low. as a result, alternative treatment strategies are required. | 2011 | 21206418 |
| evaluation of helicobacter pylori eradication by triple therapy plus lactobacillus acidophilus compared to triple therapy alone. | the purpose of this study was to evaluate the influence of adding lactobacillus acidophilus to a triple regimen for helicobacter pylori eradication in untreated patients with peptic ulcers or ulcer-scars. this was a pre-randomized, single-blind, interventional, treatment-efficacy study with active controls and parallel-assignment, set in coimbra, portugal, on 62 consecutive h. pylori-positive untreated adults with peptic ulcers or ulcer-scars, diagnosed by gastroduodenoscopy, with pre-treatment ... | 2011 | 21207091 |
| the structure of the helicobacter pylori ferric uptake regulator fur reveals three functional metal binding sites. | fur, the ferric uptake regulator, is a transcription factor that controls iron metabolism in bacteria. binding of ferrous iron to fur triggers a conformational change that activates the protein for binding to specific dna sequences named fur boxes. in helicobacter pylori, hpfur is involved in acid response and is important for gastric colonization in model animals. here we present the crystal structure of a functionally active hpfur mutant (hpfur2m; c78s-c150s) bound to zinc. although its fold i ... | 2011 | 21208302 |
| [low penetrance gene polymorphisms involved in helicobacter pylori-immune response. relevance on gastric cancer risk.] | gastric cancer is a complex pathology which represents a worldwide health burden due to its high prevalence and poor prognosis. therefore, prevention and early detection are considered the best options for controlling the disease. current research is based on the study of genetic variants that confer a higher risk and their interactions with environmental exposure. a deeper knowledge of factors involved on gastric cancer development may allow identification of those individuals at elevated risk ... | 2011 | 21208631 |
| hospitalisation of and mortality from bleeding peptic ulcer in sweden: a nationwide time-trend analysis. | background: time-trend analyses of incidence and mortality in bleeding peptic ulcer show divergent results. | 2011 | 21210831 |
| a novel inhibitory domain of helicobacter pylori protein caga reduces caga effects on host cell biology. | the helicobacter pylori protein caga (cytotoxin-associated gene a) is associated with an increased risk for gastric cancer formation. after attachment to epithelial cells, the bacteria inject caga via a type iv secretion apparatus into host cells, where it exerts its biological activity. host cell responses to intracellular caga have been linked exclusively to signaling motifs in the c terminus of the caga protein. little is known about the functional role of the remaining caga protein. using tr ... | 2011 | 21212271 |
| birth and death of genes linked to chromosomal inversion. | the birth and death of genes is central to adaptive evolution, yet the underlying genome dynamics remain elusive. the availability of closely related complete genome sequences helps to follow changes in gene contents and clarify their relationship to overall genome organization. helicobacter pylori, bacteria in our stomach, are known for their extreme genome plasticity through mutation and recombination and will make a good target for such an analysis. in comparing their complete genome sequence ... | 2011 | 21212362 |
| ibd: stress causes flares of ibd--how much evidence is enough? | 2011 | 21212773 | |
| inefficiency of rapid urease test for confirmation of helicobacter pylori. | 2011 | 21196663 | |
| detection, isolation, and characterization of helicobacter species from the gastrointestinal tract of the brushtail possum. | the presence of helicobacter species in australian marsupials was examined systematically using microscopy, culture, and pcr in different regions of the gastrointestinal tract (git) and in the liver of brushtail possums (btps) (trichosurus vulpecula), a common australian marsupial that feeds on eucalyptus leaves. the spatial distribution of helicobacter species in the git sections also was examined microscopically in silver-stained sections and by fluorescent in situ hybridization (fish) using a ... | 2011 | 21216901 |
| in vivo recognition of the feca3 target promoter by helicobacter pylori nikr. | in helicobacter pylori, the transcriptional regulator hpnikr represses transcription of the feca3 gene by binding to two adjacent operators spanning a region of almost 80 nucleotides along the feca3 promoter in a nickel-dependent manner. by employing hydroxyl radical footprinting, we mapped the protected nucleotides within each operator. three short sequences rich in a and t nucleotides were identified within each operator, comprising just 24 bases for both operators, with 4 or 5 protected bases ... | 2011 | 21216998 |
| elevated risk of colorectal adenoma with helicobacter pylori-related chronic gastritis: a population-based case-control study. | the present study investigated correlations between helicobacter pylori infection or chronic atrophic gastritis (cag) and risk of colorectal adenoma in a population-based case-control study. subjects comprised asymptomatic, middle-aged, male japanese factory workers who participated in an annual health check-up program, including cancer screening with colonoscopy. we selected 239 colorectal adenoma cases based on histological evaluation and 239 age-matched adenoma-free controls, and evaluated co ... | 2011 | 21225622 |
| [etiology of atherosclerosis-- special reference to bacterial infection and viral infection]. | atherosclerosis is caused by multiple factors. infectious disease has been proposed to be one of the causative factors, and several bacteria and viruses have been studied for their correlations with atherosclerotic diseases; these organisms include chlamydia pneumoniae, helicobacter pylori, hiv, cmv, hsv and hepatitis viruses. many underlying mechanisms that infectious diseases cause atherosclerosis have been proposed; most of them suggested that inflammatory process provoked by infectious disea ... | 2011 | 21226255 |
| [strategies for extermination of gastric cancer from japan]. | to prevent deaths from gastric cancer, it is important to combine h. pylori eradication for primary prevention with endoscopic follow-up for secondary prevention. we estimated the cost of this strategy. gastric cancer screening by simultaneous measurement of serum pepsinogen and h. pylori antibody combined with eradication of h. pylori in all individuals at risk would initially increase national healthcare expenditure, but would eventually archive great savings by markedly reducing the cost of t ... | 2011 | 21226280 |
| effects of blood group antigen-binding adhesin expression during helicobacter pylori infection of mongolian gerbils. | helicobacter pylori outer membrane proteins, such as the blood group antigen-binding adhesin (baba), are associated with severe pathological outcomes. however, the in vivo role of baba during long-term infection is not clear. in this study, mongolian gerbils were infected with h. pylori and necropsied continuously during 18 months. bacterial clones were recovered and analyzed for baba expression, leb-binding activity, and adhesion to gastric mucosa. baba expression was completely absent by 6 mon ... | 2011 | 21227917 |
| sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract. | glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. the gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. in addition, the membrane-bound glycosylated proteins and lipids create a glycocalyx, which remains adherent on each cell and is dynamic and responsive to the physiological state and environment of the cell. th ... | 2011 | 21228430 |
| health benefits of probiotics: are mixtures more effective than single strains? | most studies on probiotics utilise single strains, sometimes incorporated into yoghurts. there are fewer studies on efficacy of mixtures of probiotic strains. this review examines the evidence that (a) probiotic mixtures are beneficial for a range of health-related outcomes and (b) mixtures are more or less effective than their component strains administered separately. | 2011 | 21229254 |
| geographical differences in autoantibodies and anti-infectious agents antibodies among healthy adults. | much is known about the geoepidemiology of defined autoimmune diseases (ad); however, there is currently limited data regarding the prevalence of autoantibodies among healthy populations of different geographical areas. the aim of this study was to evaluate a large profile of autoantibodies in healthy adults from distinct global regions as well as the prevalence of anti-infectious agents antibodies in those regions. sera samples from 557 healthy donors were obtained at six centers located in dif ... | 2011 | 21229335 |
| the specific linker phosphorylation of smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of helicobacter-associated gastritis. | the gastric corpus and antrum are believed to contain epithelial stem cells in the isthmus. however, the lack of useful markers has hindered studies of their origin. we explored whether smad2/3, phosphorylated at specific linker threonine residues (psmad2/3l-thr), could serve as a marker for stem cells. | 2011 | 21229365 |
| risk factors for erosive esophagitis: a cross-sectional study of a large number of japanese males. | the impact of obesity on gastroesophageal reflux disease remains controversial. we undertook this study, with a large sample size, to investigate risk factors for endoscopic erosive esophagitis by multivariate analysis, including visceral adipose tissue (vat) and subcutaneous adipose tissue (sat) as covariates. | 2011 | 21229366 |
| mild enteropathy as a cause of iron-deficiency anaemia of previously unknown origin. | we assessed whether mild enteropathy with negative coeliac serology may be gluten-dependent, and a cause of iron-deficiency anaemia. in cases not responding to gluten-free diet, the role of helicobacter pylori infection was evaluated. | 2011 | 21233030 |
| helicobacter pylori induces mitochondrial dna mutation and reactive oxygen species level in ags cells. | to investigate the role of ros in the helicobacter pylori (hp) induced mtdna mutations, ags cells were treated by extracts of hp11638 or hp11638m. the ros levels, cytochrome c reductions, and intracellular atp levels were measured. the coding region and the d-loop region were amplified and sequenced. results showed the ros levels, cytochrome c reduction and mtdna mutations were markedly increased and cell viability decreased after treatment with both hp extracts, and 616 mutations were detected ... | 2011 | 21234270 |
| first detection of helicobacter canis in chronic duodenal ulcerations from a patient with crohn's disease. | 2011 | 21234909 | |
| helicovax: epitope-based therapeutic helicobacter pylori vaccination in a mouse model. | helicobacter pylori is the leading cause of gastritis, peptic ulcer disease and gastric adenocarcinoma and lymphoma in humans. due to the decreasing efficacy of anti-h. pylori antibiotic therapy in clinical practice, there is renewed interest in the development of anti-h. pylori vaccines. in this study an in silico-based approach was utilized to develop a multi-epitope dna-prime/peptide-boost immunization strategy using informatics tools. the efficacy of this construct was then assessed as a the ... | 2011 | 21236233 |
| the prevalence of premalignant gastric lesions in asymptomatic patients: predicting the future incidence of gastric cancer. | helicobacter pylori is the main risk-factor for gastric cancer through a cascade from gastritis through atrophic gastritis (ag), intestinal metaplasia (im), dysplasia (dys) to malignancy. the presence of these lesions in the general population predicts the gastric cancer incidence in the coming decades. prevalence data are mostly obtained from serological studies and endoscopy data in symptomatic patients. | 2011 | 21239166 |
| effects of metal on the biochemical properties of helicobacter pylori hypb, a maturation factor of [nife]-hydrogenase and urease. | the biosyntheses of the [nife]-hydrogenase and urease enzymes in helicobacter pylori require several accessory proteins for proper construction of the nickel-containing metallocenters. the hydrogenase accessory proteins hypa and hypb, a gtpase, have been implicated in the nickel delivery steps of both enzymes. in this study, the metal-binding properties of h. pylori hypb were characterized, and the effects of metal binding on the biochemical behavior of the protein were examined. the protein can ... | 2011 | 21239585 |
| inlet patch: clinical presentation and outcome in children. | an inlet patch (ip) is defined as heterotopic gastric mucosa located in the proximal esophagus. little information is available in children. the aim of this retrospective study was to assess clinical significance, endoscopic and histological characteristics, and natural history of ip in children. | 2011 | 21240021 |
| citric acid inhibits growth of helicobacter pylori in vitro: a new strategy for eradication. | about 50% of the world population is infected with helicobacter pylori. the association of peptic ulcer disease with helicobacter pylori is well documented. therefore eradication is obligatory. however, the high costs of multidrug therapy, the resistance of helicobacter pylori to antibiotics as well as the sometimes present drug intolerance are limiting factors. | 2011 | 21240685 |
| the role of interleukin-17 in the helicobacter pylori induced infection and immunity. | helicobacter pylori infection is regarded as the major cause of various gastric diseases and induces the production of several cytokines including interleukin-17 (il-17) recently recognized as an important player in the mammalian immune system. | 2011 | 21241406 |
| strain-dependent proliferation in response to human gastric mucin and adhesion properties of helicobacter pylori are not affected by co-isolated lactobacillus sp. | helicobacter pylori colonize the mucus layer that covers the gastric epithelium and can cause gastritis, ulcers, and gastric cancer. recently, lactobacillus sp. have also been found to reside in this niche permanently. this study compares adhesive properties and proliferation of co-isolated lactobacilli and h. pylori in the presence of mucins and investigates possibilities for lactobacilli-mediated inhibition of h. pylori. | 2011 | 21241407 |
| differences of urease activity and expression of associated genes according to gastric topography. | we hypothesize that ph difference between acid-secreting corpus and non-secreting antrum might influence the activity of h. pylori's urease and/or related genes. we therefore measured urease activity and the expression of amie whose encoded protein that hydrolyzes short-chain amides to produce ammonia. | 2011 | 21241408 |
| pediatric helicobacter pylori infection and circulating t-lymphocyte activation and differentiation. | in this study, h. pylori-infected and noninfected children with gastritis were compared to a control group with respect to circulating cd4(+) and cd8(+) t lymphocytes expressing activation and differentiation markers. additionally, the lymphocyte phenotypes of children with gastritis were correlated with the gastric inflammation scores. | 2011 | 21241409 |
| the role of abdominal ct scan as follow-up after complete remission with successful helicobacter pylori eradication in patients with h. pylori-positive stage i(e1) gastric malt lymphoma. | eradication of helicobacter pylori with antibiotics is the established initial treatment of patients with localized gastric mucosa-associated lymphoid tissue (malt) lymphoma. however, there are few reports on follow-up modalities to identify sustained remission in patients who achieve complete remission (cr). we therefore investigated the role of abdominal computed tomography (ct) as follow-up after cr with h. pylori eradication. | 2011 | 21241410 |
| evaluation of a new antigen for diagnosis of helicobacter pylori infection in stool of adult and children. | nowadays, there is an increasing interest in noninvasive methods to diagnose helicobacter pylori infection. indeed, they can profitably replace endoscopy in predicting the diagnosis. the stool antigen test for h. pylori is a noninvasive immunoassay to diagnose active infection with this bacterium in human fecal samples. the aim of this study was detection of alkyl hydroperoxide reductase protein (ahpc) antigen by immunoblotting in stool samples for diagnosis of h. pylori. | 2011 | 21241411 |
| analysis of antibiotic susceptibility patterns of helicobacter pylori isolates from malaysia. | the prevalence of antibiotic resistance varies in geographic areas. the information on the antibiotic susceptibility patterns of helicobacter pylori (h. pylori) in our local setting is therefore relevant as a guide for the treatment options. | 2011 | 21241412 |
| moxifloxacin-tetracycline-lansoprazole triple therapy for first-line treatment of helicobacter pylori infection: a prospective study. | to document the efficacy and tolerability of 14-day moxifloxacine-tetracycline-lansoprazole (mtl) regimens for helicobacter pylori (hp) eradication as a first-line therapy. | 2011 | 21241413 |
| the effect of helicobacter pylori and economic status on growth parameters and leptin, ghrelin, and insulin-like growth factor (igf)-i concentrations in children. | it was suggested that gastric colonization with helicobacter pylori (h. pylori) was associated with suboptimal nutrition and growth in childhood. furthermore, several studies indicated a relationship between h. pylori colonization and alterations in the circulating levels of growth-related molecules (grm). accordingly, in this study, we investigate the effect of h. pylori infection on grms and on the growth of healthy school children, taking into consideration the effect of their economic status ... | 2011 | 21241414 |
| effect of helicobacter pylori infection on barrett's esophagus and esophageal adenocarcinoma formation in a rat model of chronic gastroesophageal reflux. | to investigate the relationship between helicobacter pylori infection and barrett's esophagus (be), a rat model of chronic gastroesophageal reflux with h. pylori infection was established and the degree of inflammation, incidence of be and esophageal adenocarcinoma (ea) were evaluated. | 2011 | 21241415 |
| uropathogenic e. coli infection provokes epigenetic downregulation of cdkn2a (p16ink4a) in uroepithelial cells. | host cell and bacterial factors determine severity and duration of infections. to allow for bacteria pathogenicity and persistence, bacteria have developed mechanisms that modify expression of host genes involved in cell cycle progression, apoptosis, differentiation and the immune response. recently, helicobacter pylori infection of the stomach has been correlated with epigenetic changes in the host genome. to identify epigenetic changes during escherichia coli induced urinary tract infection (u ... | 2011 | 21242958 |
| polymorphisms in interleukin-1b (il-1b) and interleukin 1 receptor antagonist (il-1rn) genes associate with gastric cancer risk in the chinese population. | gastric cancer is one of the most common malignancies afflicting the chinese population. polymorphisms in interleukin-1b (il-1b) and interleukin-1 receptor antagonist (il-1rn) genes have been associated with increased gastric cancer risk. | 2011 | 21243433 |
| tribbles 3: a novel regulator of tlr2-mediated signaling in response to helicobacter pylori lipopolysaccharide. | helicobacter pylori causes chronic gastritis, peptic ulcers, and gastric carcinoma. gastric epithelial cells provide the first point of contact between h. pylori and the host. tlrs present on these cells recognize various microbial products, resulting in the initiation of innate immunity. although previous reports investigated tlr signaling in response to intact h. pylori, the specific contribution of h. pylori lps with regard to functional genomics and cell-signaling events has not been defined ... | 2011 | 21220698 |
| endoscopic diagnosis of open-type atrophic gastritis is related to the histological diagnosis of intestinal metaplasia and cdx2 expression. | long-term helicobacter pylori infection results in atrophic gastritis and intestinal metaplasia (im) with cdx2 expression. we have tried to determine if there was a link between endoscopic and histological diagnosis of im based on the status of aberrant cdx2 expression. | 2011 | 21221798 |
| effect of acyl chain structure and bilayer phase state on binding and penetration of a supported lipid bilayer by hpa3. | the effect of acyl chain structure and bilayer phase state on binding and penetration by the peptide hpa3 was studied using dual polarisation interferometry. this peptide is an analogue of hp(2-20) derived from the n-terminus of helicobacter pylori ribosomal protein l1 (rpl1) which has been shown to have antimicrobial and cell-penetrating properties. the binding of hpa3 to zwitterionic 1,2-dimyristoyl-sn-glycero-3-phosphocholine (dmpc) or 1-palmitolyl-2-oleyl-sn-glycero-3-phosphocholine (popc) a ... | 2011 | 21222117 |
| low serum levels of pepsinogen and gastrin 17 are predictive of extensive gastric atrophy with high-risk of early gastric cancer. | atrophic gastritis (ag) is a well-recognized high-risk condition for developing gastric cancer (gc). gastrin 17 (g17), a hormone secreted from antral g cells, regulates gastric acid secretion, and its serum level is a possible indicator of antral atrophy. serum pepsinogen is well established as the indicator of ag involving the corpus. here we investigated whether serum pg and g17 levels would be useful for determining the topographic pattern of ag and estimating the risk of gc. enrolled were 12 ... | 2011 | 21222340 |
| helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma. | 2011 | 21245429 | |
| small bowel homing t cells are associated with symptoms and delayed gastric emptying in functional dyspepsia. | immune activation may have an important pathogenic role in the irritable bowel syndrome (ibs). while little is known about immunologic function in functional dyspepsia (fd), we have observed an association between cytokine secretion by peripheral blood mononuclear cells (pbmcs) and symptoms in ibs. upper gastrointestinal inflammatory diseases are characterized by enhanced small bowel homing α4-, β7-integrin, chemokine receptor 9 (ccr9) positive t lymphocytes. we hypothesized that increased cytok ... | 2011 | 21245834 |
| the effect of helicobacter pylori treatment on remission of idiopathic central serous chorioretinopathy. | the aim of this study was to evaluate the effect of helicobacter pylori (h. pylori) treatment on remission of idiopathic central serous chorioretinopathy. | 2011 | 21245962 |
| role of abl and src family kinases in actin-cytoskeletal rearrangements induced by the helicobacter pylori caga protein. | the clinical outcome of infections with helicobacter pylori is determined by a complex interplay of host-pathogen interactions, and persistent infection with this pathogen is the major cause of developing chronic gastritis, peptic ulcers and gastric cancer. highly virulent strains encode a so-called type iv secretion system which translocates the caga effector protein into gastric epithelial target cells. injected caga becomes tyrosine-phosphorylated on epiya sequence motifs by src and abl famil ... | 2011 | 21247656 |
| helicobacter pylori infection in relation to gastric cancer progression. | gastric cancer is a major cause of cancer death worldwide, especially in developing countries. the incidence of gastric cancer varies from country to country, probably as a result of genetic, epigenetic, and environmental factors. h. pylori infection is considered as a major risk factor in the development of gastric cancer. however, the scenario varies in asian countries, exhibiting a higher rate of h. pylori infection and low incidence of gastric cancer, which could be attributed to strain-spec ... | 2011 | 21248438 |
| why is the coexistence of gastric cancer and duodenal ulcer rare? examination of factors related to both gastric cancer and duodenal ulcer. | the coexistence of gastric cancer with duodenal ulcer has been found empirically to be rare, but why it is rare is difficult to explain satisfactorily. to elucidate this question, we carried out a literature review of the subject. the frequency with which the two diseases coexist is 0.1-1.7%, and the main factor associated with both gastric cancer and duodenal ulcer is helicobacter pylori infection. however, there are marked differences between the disorders of hyperchlorhydria in duodenal ulcer ... | 2011 | 21249411 |
| sequential therapy in clarithromycin-sensitive and -resistant helicobacter pylori based on polymerase chain reaction molecular test. | the present study was designed to determine the eradication rate of 10 day sequential therapy in genotypic clarithromycin-resistant helicobacter pylori group identified by molecular polymerase chain reaction (pcr) detection in thai patients. | 2011 | 21251064 |
| usefulness of thyrogastric immune features as predictors of pernicious anaemia that lacks intrinsic factor antibody. | the study aims to evaluate the diagnostic utility of thyrogastric immune features in the identification of intrinsic factor antibody negative (ifa -ve) pernicious anaemia (pa) patients. | 2011 | 21251240 |
| early results of a canadian laparoscopic sleeve gastrectomy experience. | sleeve gastrectomy (sg) is a relatively new bariatric procedure with a number of advantages compared with roux-en-y gastric bypass. however, sg also has a number of disadvantages and associated risks. we sought to examine perioperative complications and outcomes of laparoscopic sg (lsg) in a single major canadian bariatric surgery centre (victoria, bc). | 2011 | 21251414 |
| idiopathic thrombocytopenia and helicobacter pylori infection: platelet count increase and early eradication therapy. | 2011 | 21251467 | |
| helicobacter pylori infection and gastritis: the systematic investigation of gastrointestinal diseases in china (silc). | helicobacter pylori infection remains common in east asia, though its prevalence is decreasing in western countries. h. pylori-related atrophic gastritis (ag) may reduce the likelihood of gastroesophageal reflux disease (gerd). we investigated the prevalence of h. pylori infection and ag and their association with endoscopic findings and symptom-defined gerd in shanghai. | 2011 | 21198827 |
| detection of helicobacter pylori: a faster urease test can save resources. | to investigate whether differences in the rapidity of a positive result for helicobacter pylori can save resources, by comparing two commercially available urease kits. | 2011 | 21253394 |
| impaired ifn-γ production after stimulation with bacterial components by natural killer cells from gastric cancer patients. | gastric adenocarcinoma is a major health problem world-wide, as this is the second most common cause of cancer death in the world. it has been estimated that infection by helicobacter pylori cause at least half of the gastric cancers. previously, we have demonstrated that h. pylori antigens directly activate nk cells to secrete ifn-γ. there is also a marked synergistic effect in nk cells stimulated with bacterial lysate and low levels of il-12, a cytokine which is produced by macrophages and den ... | 2011 | 21255568 |
| effects of a hp0859 (rfad) knockout mutation on lipopolysaccharide structure of helicobacter pylori 26695 and the bacterial adhesion on ags cells. | lipopolysaccharide (lps) is considered as an important virulence factor of helicobacter pylori, and contributes to infection persistence and disease severity. adp-l-glycero-d-manno-heptose-6-epimerase is an enzyme essential for lps synthesis and understanding of its biochemistry is critical for drug development. we cloned one putative ortholog of escherichia colirfad, hp0859, from h. pylori 26695. determination of the native molecular weight of the recombinant hp0859 protein suggests that the pr ... | 2011 | 21256827 |
| [effect of acid pump antagonist (revaprazan, revanex(r)) on the result of 13c urea breath test in the patients with helicobacter pylori associated peptic ulcer disease]. | 2011 | 21258193 | |
| [effect of acid pump antagonist (revaprazan, revanex(r)) on result of 13c urea breath test in patients with helicobacter pylori associated peptic ulcer disease]. | revaprazan (revanex(r)) is a novel proton pump inhibitor (ppi) that has a somewhat different effect on proton pump compared with the other ppi's, also (called as 'acid pump antagonist'). we aimed to examine the false negative rate of 13c-urea breath test (ubt) in the patients with helicobacter pylori (h. pylori) associated peptic ulcer disease who were treated with revaprazan and evaluate the anti-urease activity of revaprazan. | 2011 | 21258195 |
| age and gender differences in urea breath test results. | (13) c urea breath test (ubt) results, used for the diagnosis of helicobacter pylori infection, fluctuate in different age groups. we characterized both the age- and gender-based trends of ubt results, from early childhood through late adulthood. | 2011 | 21261618 |
| helicobacter pylori and pathogenesis of gallbladder cancer. | gallbladder cancer (gbc) is a rare but leading cause of cancer-related deaths worldwide. the incidence of gbc is increasing at an alarming rate in the varanasi region, and its etiology remains obscure. | 2011 | 21261714 |