Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [design and construction of the platform for comparative genomics]. | to design a versatile genome comparison and visualization platform based on browser/server mode supported by a local server. | 2010 | 20159684 |
| new class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets. | the urgent medical need for innovative approaches to control influenza is emphasized by the widespread resistance of circulating subtype h1n1 viruses to the leading antiviral drug oseltamivir, the pandemic threat posed by the occurrences of human infections with highly pathogenic avian h5n1 viruses, and indeed the evolving swine-origin h1n1 influenza pandemic. a recently discovered class of human monoclonal antibodies with the ability to neutralize a broad spectrum of influenza viruses (includin ... | 2010 | 20161706 |
| determination of serum antibodies against swine-origin influenza a virus h1n1/09 by immunofluorescence, haemagglutination inhibition, and by neutralization tests: how is the prevalence rate of protecting antibodies in humans? | in april 2009, a new variant of influenza a virus, subtype h1n1v emerged in mexico and spread all over the world producing the h1n1 pandemic in mankind after 1918-1920 and 1978/1979. obviously there was no herd immunity against this new virus variant. mainly young people, but less elderly were affected and presented severe and even lethal courses of disease. since virus-specific antibodies are commonly regarded as markers of partial or complete immunoprotection, we performed antibody determinati ... | 2010 | 20162304 |
| world trade, the poor and swine flu. | 2010 | 20166286 | |
| experimental inoculation of pigs with pandemic h1n1 2009 virus and hi cross-reactivity with contemporary swine influenza virus antisera. | a novel a/h1n1 was identified in the human population in north america in april 2009. the gene constellation of the virus was a combination from swine influenza a viruses (siv) of north american and eurasian lineages that had never before been identified in swine or other species. | 2010 | 20167045 |
| interferon-induced sus scrofa mx1 blocks endocytic traffic of incoming influenza a virus particles. | the interferon-induced mx proteins of vertebrates are dynamin-like gtpases, some isoforms of which can additionally inhibit the life cycle of certain rna viruses. here we show that the porcine mx1 protein (pomx1) inhibits replication of influenza a virus and we attempt to identify the step at which the viral life cycle is blocked. in infected cells expressing pomx1, the level of transcripts encoding the viral nucleoprotein is significantly lower than normal, even when secondary transcription is ... | 2010 | 20167191 |
| assessment of the efficacy of commercially available and candidate vaccines against a pandemic h1n1 2009 virus. | the emergence and global spread of the pandemic h1n1 2009 influenza virus have raised questions regarding the protective effect of available seasonal vaccines and the efficacy of a newly produced matched vaccine. | 2010 | 20170374 |
| computational analysis and determination of a highly conserved surface exposed segment in h5n1 avian flu and h1n1 swine flu neuraminidase. | catalytic activity of influenza neuraminidase (na) facilitates elution of progeny virions from infected cells and prevents their self-aggregation mediated by the catalytic site located in the body region. research on the active site of the molecule has led to development of effective inhibitors like oseltamivir, zanamivir etc, but the high rate of mutation and interspecies reassortment in viral sequences and the recent reports of oseltamivir resistant strains underlines the importance of determi ... | 2010 | 20170556 |
| youtube as a source of information on the h1n1 influenza pandemic. | the ongoing h1n1 influenza pandemic has created a significant amount of health concern. adequate dissemination of correct information about h1n1 influenza could help in decreasing the disease spread and associated anxiety in the population. | 2010 | 20171526 |
| swine influenza (h1n1) pneumonia: clinical considerations. | influenza is a viral zoonosis of birds and mammals that has probably existed since antiquity. attack rates of influenza are relatively high but mortality is relatively low. influenza mortality is highest in the very young, the very old, and the immunosuppressed. influenza has the potential for rapid spread and may involve large populations. this article examines the swine influenza (h1n1) strain of recent origin, and compares the microbiology, epidemiology, clinical presentation, differential, c ... | 2010 | 20171553 |
| swine flu vaccine adjuvants and multiple sclerosis - is there potential for harmful effect? | vaccines are generally considered a simple compound and clinicians are sometimes unaware of the possible dangers related to the new adjuvanted vaccine approach. due to their cost effectiveness and in order to obtain stronger response with a lower antigen dose, adjuvanted vaccines are preferred during pandemics. adjuvants are strong immunostimulants and may be harmful in some special patient groups, such as in multiple sclerosis. there is a significant need for the effort among clinicians to heig ... | 2010 | 20171793 |
| naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza a (h1n1) viruses. | the 2009 pandemic influenza a (h1n1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. we found that human monoclonal antibodies recognized the sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. these antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo. | 2010 | 20042511 |
| cytospin-enhanced immunofluorescence and impact of sample quality on detection of novel swine origin (h1n1) influenza virus. | nasopharyngeal swabs (n = 601) from 278 adult and 323 pediatric patients were tested within 24 h of receipt by cytospin-enhanced direct immunofluorescence antibody testing (dfa) and real-time reverse transcriptase pcr (rt-pcr) using the cdc assay. cytospin-enhanced dfa detected 230 (84.6%) of 272 swine influenza a pcr-positive results overall but 25 (92.6%) of 27 positive results in patients less than 5 years old and 208 (96.7%) of 215 positive samples with cycle threshold values of <26. | 2010 | 20042632 |
| swine-origin pandemic h1n1 influenza virus-like particles produced in insect cells induce hemagglutination inhibiting antibodies in balb/c mice. | recent outbreaks of influenza a highlight the importance of rapid and sufficient supply for pandemic and inter-pandemic vaccines. classical manufacturing methods for influenza vaccines fail to satisfy this demand. alternatively, cell culture-based production systems and virus-like particle (vlp)-based technologies have been established. we developed swine-origin pandemic h1n1 influenza vlps consisting of hemagglutinin (a/california/04/2009) and matrix protein. hemagglutinin and matrix protein we ... | 2010 | 20041443 |
| ventilator management for hypoxemic respiratory failure attributable to h1n1 novel swine origin influenza virus. | novel h1n1 swine origin influenza virus has led to a worldwide pandemic. during the pandemic, a significant number of patients became critically ill primarily because of respiratory failure. most of these patients required intubation and mechanical ventilation and were treated with conventional modes of mechanical ventilation using a lung-protective strategy with low tidal volumes, plateau pressures <30 to 35 cm h2o, and optimal positive end-expiratory pressure. in some patients with persistent ... | 2010 | 20042855 |
| human host factors required for influenza virus replication. | influenza a virus is an rna virus that encodes up to 11 proteins and this small coding capacity demands that the virus use the host cellular machinery for many aspects of its life cycle. knowledge of these host cell requirements not only informs us of the molecular pathways exploited by the virus but also provides further targets that could be pursued for antiviral drug development. here we use an integrative systems approach, based on genome-wide rna interference screening, to identify 295 cell ... | 2010 | 20027183 |
| detection of molecular markers of drug resistance in 2009 pandemic influenza a (h1n1) viruses by pyrosequencing. | the m2 blockers amantadine and rimantadine and the neuraminidase (na) inhibitors (nais) oseltamivir and zanamivir are approved by the fda for use for the control of influenza a virus infections. the 2009 pandemic influenza a (h1n1) viruses (h1n1pdm) are reassortants that acquired m and na gene segments from a eurasian adamantane-resistant swine influenza virus. nai resistance in the h1n1pdm viruses has been rare, and its occurrence is mainly limited to oseltamivir-exposed patients. the pyroseque ... | 2010 | 20028826 |
| cytokine profiles induced by the novel swine-origin influenza a/h1n1 virus: implications for treatment strategies. | background. given the apparent high mortality associated with the novel swine-origin influenza a/h1n1 virus (s-oiv) in mexico, we aimed to study the cytokine profiles induced by s-oiv and the effect of immunomodulators. methods. we assayed cytokines and their messenger rna (mrna) levels in culture supernatants of human macrophages infected with h5n1, s-oiv california/04/2009 (s-oiv-ca), s-oiv hong kong/415742 (s-oiv-hk), or seasonal h1n1 with or without celecoxib and mesalazine. results. among t ... | 2010 | 20030555 |
| serologic cross-reactivity with pandemic (h1n1) 2009 virus in pigs, europe. | we tested serum samples from pigs infected or vaccinated with european swine influenza viruses (sivs) in hemagglutination-inhibition assays against pandemic (h1n1) 2009 virus and related north american sivs. we found more serologic cross-reaction than expected. data suggest pigs in europe may have partial immunity to pandemic (h1n1) 2009 virus. | 2010 | 20031049 |
| swine-origin influenza a (h1n1) viral infection in children: initial chest radiographic findings. | purpose: to evaluate initial chest radiographic findings of swine-origin influenza a (s-oiv) (also known as h1n1) viral infection in children. materials and methods: this was an institutional review board-approved, hipaa-compliant retrospective study of 108 patients who had microbiologically confirmed s-oiv infection and available initial chest radiographs obtained between april 2009 and october 2009. the final study group was divided on the basis of clinical course (group 1, outpatients without ... | 2010 | 20032128 |
| occurrence of a pig respiratory disease associated with swine influenza a (h1n2) virus in tochigi prefecture, japan. | in february 2008, a feeder pig herd of the affected farm in tochigi prefecture, japan, showed increasing respiratory symptoms; by april, the situation worsened with 12-16 pigs dying daily. diagnostic tests revealed the presence of h1n2 subtype of swine influenza virus (siv) and pasteurella multocida from nasal swab and lung emulsion. serological tests by hemagglutination inhibition method and enzyme-linked immunosorbent assay method (elisa; imported from u.s.a.) indicated the spread of siv into ... | 2010 | 20035121 |
| broad-spectrum and virus-specific nucleic acid-based antivirals against influenza. | rapid increase in drug-resistant influenza virus isolates, and pandemic threat posed by highly pathogenic avian influenza a and swine flu viruses provide clear and compelling reasons for fast tracking development of novel antiviral drugs. nucleic acid-based drugs represent a promising class of novel antiviral agents that can be designed to target various seasonal, pandemic and avian influenza viruses. nucleic acids can be designed to elicit broad-spectrum antiviral responses in the host, by supp ... | 2010 | 20036985 |
| swine flu: a new emerging disease. | swine flu is an important zoonotic disease that has been recognized as an important global health problem by any one of several types of swine influenza virus or swine-origin influenza virus. due to its increasing incidence in many countries of the world and occurrence of several large outbreaks in present year, it is a burning issue nowadays. it is thought to be a mutation--more specifically, a reassortment of four known strains of influenza a virus subtype h1n1. swine influenza virus is common ... | 2010 | 20046190 |
| preferential lower respiratory tract infection in swine-origin 2009 a(h1n1) influenza. | we report a case of 2009 influenza a(h1n1) virus infection in which virus was detected predominantly in specimens from the lower respiratory tract but was absent or at very low levels in nasopharyngeal swab samples. this presentation suggests that, in certain hosts or for particular variants of 2009 a(h1n1) virus, the lower respiratory tract may be the preferred site of infection. | 2010 | 20047483 |
| predicting the antigenic structure of the pandemic (h1n1) 2009 influenza virus hemagglutinin. | the pandemic influenza virus (2009 h1n1) was recently introduced into the human population. the hemagglutinin (ha) gene of 2009 h1n1 is derived from "classical swine h1n1" virus, which likely shares a common ancestor with the human h1n1 virus that caused the pandemic in 1918, whose descendant viruses are still circulating in the human population with highly altered antigenicity of ha. however, information on the structural basis to compare the ha antigenicity among 2009 h1n1, the 1918 pandemic, ... | 2010 | 20049332 |
| activity of isatine-sulfadimidine derivatives against 2009 pandemic h1n1 influenza virus in cell culture. | the development of antiviral drugs has provided crucial new means to mitigate or relieve the debilitating effects of many viral pathogens. new classes of inhibitors are essential to combat swine influenza viral infection. | 2010 | 20054101 |
| swine-origin h1n1 influenza a virus and dental practice: a critical review. | since the spring of 2009, there have been a considerable number of infected as well as fatal cases by virologically confirmed swine-origin h1n1 influenza a virus (s-oiv). the virus continues to spread globally. the world health organization (who) has now raised the level of s-oiv influenza pandemic alert to phase 6 ('the pandemic phase') because of the human-to-human transmission of the virus and the community-level outbreaks worldwide. the who also issues its concerns about the global surveilla ... | 2010 | 20054591 |
| oseltamivir carboxylate, the active metabolite of oseltamivir phosphate (tamiflu), detected in sewage discharge and river water in japan. | oseltamivir phosphate (op; tamiflu) is a prodrug of the anti-influenza neuraminidase inhibitor oseltamivir carboxylate (oc) and has been developed for the treatment and prevention of both a and b strains of influenza. the recent increase in op resistance in influenza a virus (h1n1; commonly called "swine flu") has raised questions about the widespread use of tamiflu in seasonal epidemics and the potential ecotoxicologic risk associated with its use in the event of a pandemic. | 2010 | 20056566 |
| initial behavioural and attitudinal responses to influenza a, h1n1 ('swine flu'). | 2010 | 20056970 | |
| does glycosylation as a modifier of original antigenic sin explain the case age distribution and unusual toxicity in pandemic novel h1n1 influenza? | a pandemic novel h1n1 swine-origin influenza virus has emerged. most recently the world health organization has announced that in a country-dependent fashion, up to 15% of cases may require hospitalization, often including respiratory support. it is now clear that healthy children and young adults are disproportionately affected, most unusually among those with severe respiratory disease without underlying conditions. one possible explanation for this case age distribution is the doctrine of ori ... | 2010 | 20059763 |
| prevention of nosocomial transmission of swine-origin pandemic influenza virus a/h1n1 by infection control bundle. | after the outbreak of severe acute respiratory syndrome in hong kong, the importance of preventing nosocomial transmission of respiratory viruses has become a top priority in infection control. during the containment and early mitigation phases of the swine-origin influenza virus (s-oiv) a h1n1 pandemic, an infection control bundle consisting of multiple coherent measures was organised by our infection control team to minimise nosocomial transmission. this included repeated open staff forum achi ... | 2010 | 20061056 |
| critical issues related to porcine xenograft exposure to human viruses: lessons from allotransplantation. | xenotransplantation of tissues from swine into humans poses the threat of bidirectional transfer of porcine or human microorganisms to the recipient or to the xenograft, respectively. this review focuses on recipient-derived infection. recent data are reviewed that assess the susceptibility of porcine cells to human viruses. on the basis of the experience in allotransplantation, potential consequences for the xenograft are discussed. | 2010 | 20061950 |
| government is in talks with gsk to offload surplus swine flu vaccine. | 2010 | 20064849 | |
| swine flu (s-oiv) pandemic. | 2010 | 20065045 | |
| development of a rapid automated influenza a, influenza b, and respiratory syncytial virus a/b multiplex real-time rt-pcr assay and its use during the 2009 h1n1 swine-origin influenza virus epidemic in milwaukee, wisconsin. | rapid, semiautomated, and fully automated multiplex real-time rt-pcr assays were developed and validated for the detection of influenza (flu) a, flu b, and respiratory syncytial virus (rsv) from nasopharyngeal specimens. the assays can detect human h1n1, h3n2, and swine-origin (s-oiv) h1n1 flu a viruses and were effectively used to distinguish flu a infections (of all subtypes) from flu b and rsv infections during the current s-oiv outbreak in milwaukee, wi. the analytical limits of detection we ... | 2010 | 19959800 |
| significant neutralizing activity of human immunoglobulin preparations against pandemic 2009 h1n1. | 2010 | 19961480 | |
| rapid diagnosis of swine-origin influenza a (h1n1) virus (s-oiv): useful or hype? | 2010 | 19995179 | |
| diagnostic performance of rapid influenza antigen assays in patients infected with the new influenza a (h1n1) virus. | the new swine influenza (h1n1) requires fast and accurate diagnosis. currently, there are few reports about the diagnostic performance of influenza antigen tests with regard to the h1n1 virus infection. we evaluated the reactivity of eight commercially available rapid antigen tests in samples from confirmed infected patients. | 2010 | 19995180 |
| subtype identification of the novel a h1n1 and other human influenza a viruses using an oligonucleotide microarray. | a novel strain of influenza a (h1n1) virus was isolated in mexico and the us in march and april 2009. this novel virus spread to many countries and regions in a few months, and who raised the level of pandemic alert from phase 5 to phase 6 on june 11, 2009. the accurate identification of h1n1 virus and other human seasonal influenza a viruses is very important for further treatment and control of their infections. in this study, we developed an oligonucleotide microarray to subtype human h1n1, h ... | 2010 | 19998047 |
| [influenza a (h1n1) virus infection in humans: review to 30th october 2009]. | since human infection by a novel influenza virus a h1n1 of swine origin was reported in april 2009, the virus has spread worldwide causing a pandemic. in the southern hemisphere, the first pandemic wave has taken place, coinciding with austral winter. in the northern hemisphere, transmission has been sustained under the basal level of epidemic until the first weeks of october, when incidence rates have risen up to the pidemic level in some countries, including spain. this work reviews the differ ... | 2010 | 19962791 |
| the value of lung ultrasound monitoring in h1n1 acute respiratory distress syndrome. | we present the case of a healthy young male who developed acute respiratory failure as a result of infection with influenza a/h1n1 of swine-origin and in whom ventilatory support was optimised and recovery of lung function was monitored by the use of sequential chest ultrasound examinations. the potential pivotal role of bedside lung ultrasonography in h1n1-induced respiratory failure is discussed. | 2010 | 20002364 |
| swine influenza (h1n1) pneumonia during the 'herald wave' of the pandemic: no increase in bacterial pneumonia without empirical antibiotics. | 2010 | 20005682 | |
| one-step real-time rt-pcr for pandemic influenza a virus (h1n1) 2009 matrix gene detection in swine samples. | in the spring of 2009, a novel (h1n1) influenza a virus began to spread among humans worldwide. although the 2009 h1n1 is related genetically to swine influenza viruses, human infection has not been connected to pig exposure. because the virus is now circulating widely in the human population, swine herds are at increased risk of becoming infected. in order to investigate potential outbreaks of the 2009 pandemic virus in pigs, a quantitative real-time reverse transcriptase-polymerase chain react ... | 2010 | 20005904 |
| swine infuenza (h1n1) pneumonia: bacterial airway colonization common but fatalities due to bacterial pneumonia remain relatively rare. | 2010 | 20007024 | |
| structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 h2n2 pandemic. | the hemagglutinin (ha) envelope protein of influenza viruses mediates essential viral functions, including receptor binding and membrane fusion, and is the major viral antigen for antibody neutralization. the 1957 h2n2 subtype (asian flu) was one of the three great influenza pandemics of the last century and caused 1 million deaths globally from 1957 to 1968. three crystal structures of 1957 h2 has have been determined at 1.60 to 1.75 a resolutions to investigate the structural basis for their a ... | 2010 | 20007271 |
| alterations in receptor-binding properties of swine influenza viruses of the h1 subtype after isolation in embryonated chicken eggs. | alterations of the receptor-binding properties of swine influenza a viruses (sivs) during their isolation in embryonated chicken eggs have not been well studied. in this study, the receptor-binding properties of classical h1 sivs isolated solely in eggs or madin-darby canine kidney (mdck) cells were examined. sequencing analysis revealed substitutions of d190v/n or d225g in the haemagglutinin (ha) proteins in egg isolates, whereas mdck isolates retained ha genes identical to those of the origina ... | 2010 | 20007353 |
| antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from alpinia katsumadai. | at present, neuraminidase (na) inhibitors are the mainstay of pharmacological strategies to fight against global pandemic influenza. in the search for new antiviral drug leads from nature, the seed extract of alpinia katsumadai has been phytochemically investigated. among the six isolated constituents, four diarylheptanoids showed in vitro na inhibitory activities in low micromolar ranges against human influenza virus a/pr/8/34 of subtype h1n1. the most promising constituent, katsumadain a (4; i ... | 2010 | 20014777 |
| honey bee sting and venom offering active as well as passive immunization could reduce swine flu pandemic a (h1n1). | 2010 | 20015597 | |
| genetic and pathobiologic characterization of pandemic h1n1 2009 influenza viruses from a naturally infected swine herd. | since its initial identification in mexico and the united states, concerns have been raised that the novel h1n1 influenza virus might cause a pandemic of severity comparable to that of the 1918 pandemic. in late april 2009, viruses phylogenetically related to pandemic h1n1 influenza virus were isolated from an outbreak on a canadian pig farm. this outbreak also had epidemiological links to a suspected human case. experimental infections carried out in pigs using one of the swine isolates from th ... | 2010 | 20015998 |
| animal models for the preclinical evaluation of candidate influenza vaccines. | at present, new influenza a (h1n1)2009 viruses of swine origin are responsible for the first influenza pandemic of the 21st century. in addition, highly pathogenic avian influenza a/h5n1 viruses continue to cause outbreaks in poultry and, after zoonotic transmission, cause an ever-increasing number of human cases, of which 59% have a fatal clinical outcome. it is also feared that these viruses adapt to replication in humans and become transmissible from human to human. the development of effecti ... | 2010 | 20021306 |
| phenotypic characteristics of novel swine-origin influenza a/california/07/2009 (h1n1) virus. | the 2009 novel a(h1n1) virus appears to be of swine origin. this strain causing the current outbreaks is a new virus that has not been seen previously either in humans or animals. we have previously reported that viruses causing pandemics or large outbreaks were able to grow at a temperature above the normal physiological range (temperature resistance, non-ts phenotype), were found to be inhibitor resistant and restricted in replication at suboptimal temperature (sensitivity to grow at low tempe ... | 2010 | 20021501 |
| an ex vivo swine tracheal organ culture for the study of influenza infection. | the threat posed by swine influenza viruses with potential to transmit from pig populations to other hosts, including humans, requires the development of new experimental systems to study different aspects of influenza infection. ex vivo organ culture (evoc) systems have been successfully used in the study of both human and animal respiratory pathogens. | 2010 | 20021502 |
| pathological and ultrastructural analysis of surgical lung biopsies in patients with swine-origin influenza type a/h1n1 and acute respiratory failure. | cases of h1n1 and other pulmonary infections evolve to acute respiratory failure and death when co-infections or lung injury predominate over the immune response, thus requiring early diagnosis to improve treatment. | 2010 | 21340209 |
| monoclonal antibodies isolated from human b cells neutralize a broad range of h1 subtype influenza a viruses including swine-origin influenza virus (s-oiv). | the new h1n1 swine-origin influenza virus (s-oiv) strain is a global health problem. the elucidation of the virus-host relationship is crucial for the control of the new infection. two human monoclonal antibody fab fragments (hmab) neutralizing the novel h1n1 influenza strain at very low concentrations were cloned before the emergence of s-oiv from a patient who had a broad-range h1n1 serum neutralizing activity. the two hmabs neutralized all tested h1n1 strains, including s-oiv and a swine stra ... | 2010 | 20096915 |
| [current situation of a/h1n1 influenza in the world]. | between march and april, 2009 a new strain of influenza capable of causing severe disease and mortality in humans was identified in north america, leading to the declaration by the world health organization (who) of the first pandemic of the 21st century. the prompt intervention of world health authorities allowed the early identification of the virus as triple assortment a(h1n1) derived from avian, swine and human viruses, and a descendant of the a(h1n1) virus that caused the 1918 influenza pan ... | 2010 | 21384641 |
| novel swine influenza a/h1n1 and the phase six pandemic. | the family orthomyxoviridae consists of influenza a virus which is negative sense single stranded virus. the genome of the virus is segmented and possesses a peculiar trait of genetic reassortment. the influenza virus on its envelop consists of the antigenic glycoprotein like haemagglutinin (ha) and neuraminidase (na). the changes in those glycoprotein components due to antigenic shift and antigenic drift leads to the development of new strain of influenza a viruses. now the novel swine influenz ... | 2010 | 22049835 |
| physicians' recommendations to their patients concerning a novel pandemic vaccine: a cross-sectional survey of the 2009 influenza a/h1n1 pandemic in japan. | objectives: striking a balance between the rapid availability of a novel vaccine while ensuring its safety, quality, and efficacy is a major challenge during a pandemic. we aimed to elucidate physicians' attitudes regarding the novel vaccine during the influenza a/h1n1 pandemic of 2009, and to determine factors that affected their vaccination recommendations to patients. methods: of a random sample of 1,000 general practitioners (gps) in japan, 515 participated in the cross-sectional anonymous s ... | 2010 | 21431784 |
| [analyses of serological and genetic characteristics on novel h1n1 influenza a virus from the infected patient in shenzhen]. | analysis of serological and genetic characteristics on 2009 swine-origin influenza a (h1n1) virus (s-oiv) isolated from four patients with severe disease in shenzhen were performed. microneutralization assay showed that the neutralizing antibody titers of the infected patients did not exceed 1 : 20 in a short term post infection, which could not neutralize the viruses efficiently. hemagglutination inhibition (hi) tests confirmed that the antigenicity of s-oiv from the patients was distinct from ... | 2010 | 21344749 |
| the effectiveness of an educational intervention on clinicians' knowledge of pandemic influenza. | the growing numbers of h1n1 "swine influenza" cases should prompt national health systems to achieve dual preparedness: preparedness of clinicians to recognize and treat cases of human h1n1 flu, and national preparedness for an influenza pandemic. this is similar to recent contingency planning for an avian flu pandemic. | 2010 | 21337812 |
| avian and human influenza a virus receptors in trachea and lung of animals. | influenza a viruses are capable of crossing the specific barrier between human beings and animals resulting in interspecies transmission. the important factor of potential infectivity of influenza a viruses is the suitability of the receptor binding site of the host and viruses. the affinities of avian and human influenza virus to bind with the receptors and the distributions of receptors in animals are different. | 2010 | 21337915 |
| dna damage and mutagenesis: is it an issue for swine flu? | 2010 | 21329187 | |
| communicating information regarding human h1n1-09 virus to high-risk consumers: knowledge and understanding of copd patients in melbourne, australia. | one of the public health challenges during an influenza pandemic is how to rapidly access groups of high-risk individuals to ensure that they have accurate information regarding prevention and management of infection. the aim of this survey was to evaluate the level of understanding of the h1n1-09 (swine flu) pandemic, amongst a high-risk group of individuals with chronic lung disease. this study was conducted in melbourne, australia towards the end of the 2009 pandemic. | 2010 | 21319468 |
| understanding the influenza a h1n1 2009 pandemic. | a new strain of influenza a virus, with quadruple segment translocation in its rna, caused an outbreak of human infection in april 2009 in usa and mexico. it was classified as influenza a h1n1 2009. the genetic material originates from three different species: human, avian and swine. by june 2009, the world health organization (who) had classified this strain as a pandemic virus, making it the first pandemic in 40 years. influenza a h1n1 2009 is transmitted by respiratory droplets; the transmiss ... | 2010 | 21509228 |
| [pandemic influenza a/h1n1 (sw2009) in russia: epidemiology, diagnosis, clinical picture, and treatment]. | to study the epidemiological and clinical features of the 2009-2010 pandemic influenza in russia. | 2010 | 21381341 |
| swine flu--an epidemiological review. | 2009 | 22010480 | |
| the early molecular epidemiology of the swine-origin a/h1n1 human influenza pandemic. | swine-origin pandemic human influenza a virus (h1n1pdm) has spread rapidly around the world since its initial documentation in april 2009. here we have updated initial estimates of the rate of molecular evolution and estimates of the time of origin of this virus in the human population using the large number of viral sequences made available as part of the public health response to this global pandemic. currently sampled h1n1pdm sequences share a most recent common ancestor in the first 7 weeks ... | 2009 | 20025195 |
| swine flu has been "considerably less lethal than feared," says donaldson. | 2009 | 20026511 | |
| virus of the year. the novel h1n1 influenza. | 2009 | 20019257 | |
| swine flu (h1n1/09): an interim assessment. | 2009 | 20019860 | |
| absence of 2009 pandemic h1n1 influenza a virus in fresh pork. | the emergence of the pandemic 2009 h1n1 influenza a virus in humans and subsequent discovery that it was of swine influenza virus lineages raised concern over the safety of pork. pigs experimentally infected with pandemic 2009 h1n1 influenza a virus developed respiratory disease; however, there was no evidence for systemic disease to suggest that pork from pigs infected with h1n1 influenza would contain infectious virus. these findings support the who recommendation that pork harvested from pand ... | 2009 | 20020048 |
| gps make deals with local nhs to vaccinate children against swine flu. | 2009 | 20008016 | |
| passive immunity to pandemic h1n1 2009 by swine flu parties. | the general population is concerned about the probable devastating effects of pandemic h1n1 2009. based upon the 1918 spanish flu pandemic, scientific publications and theories, the idea of swine flu parties to achieve passive immunity against pandemic h1n1 2009 has been proposed. public health officials have asked the general public not to resort to this method. however, no concrete evidence of the reasoning behind the recommendation has been given. in this paper, we have dynamically modeled th ... | 2009 | 20009274 |
| novel swine-origin (s-oiv) h1n1 influenza a pneumonia in a lung transplant patient: a case report and review of the literature on performance characteristics of rapid screening tests for the s-oiv. | rapid screening tests are insensitive for detecting the novel swine-origin influenza a (h1n1) virus (s-oiv), and false negatives can delay the diagnosis and initiation of appropriate antiviral therapy. the case of a 26-year-old double lung transplant recipient presenting with fever, bilateral pulmonary infiltrates, and a negative influenza direct immunofluorescent antibody on bronchoalveolar lavage is presented. a diagnosis was made, and antiviral therapy was started 10 days after the initial br ... | 2009 | 20010157 |
| swine flu infection among medical students: an issue of concern. | 2009 | 20004815 | |
| fall in swine flu cases may not signal an end of the epidemic, warns professor donaldson. | 2009 | 19969608 | |
| genomic signatures of influenza a pandemic (h1n1) 2009 virus. | adaptive mutations that have contributed to the emergence of influenza a pandemic (h1n1) 2009 virus, which can replicate and transmit among humans, remain unknown. we conducted a large-scale scanning of influenza protein sequences and identified amino acid-conserving positions that are specific to host species, called signatures. of 47 signatures that separate avian viruses from human viruses by their nonglycoproteins, 8 were human-like in the pandemic (h1n1) 2009 virus. close examination of the ... | 2009 | 19998748 |
| [bird populations--hatching grounds of pandemic influenza viruses?]. | aquatic wild birds constitute the natural reservoir of influenza a viruses. under appropriate selection pressure these viruses display a remarkable genetic flexibility which is based on their high mutation rate. at least 16 subtypes of the viral hemagglutinin glycoprotein (ha) und 9 of the viral neuraminidase (na) are distinguishable as a result of natural evolution. due to the segmentation of the viral genome, genetic reassortments and, thus, a theoretically unrestricted combination of ha and n ... | 2009 | 19999379 |
| swine influenza viruses and their pandemic potential. | 2009 | 20000235 | |
| adaptive strategies of the influenza virus polymerase for replication in humans. | transmission of influenza viruses into the human population requires surmounting barriers to cross-species infection. changes in the influenza polymerase overcome one such barrier. viruses isolated from birds generally contain polymerases with the avian-signature glutamic acid at amino acid 627 in the pb2 subunit. these polymerases display restricted activity in human cells. an adaptive change in this residue from glutamic acid to the human-signature lysine confers high levels of polymerase acti ... | 2009 | 19995968 |
| early assessment of anxiety and behavioral response to novel swine-origin influenza a(h1n1). | since late april, 2009, a novel influenza virus a (h1n1), generally referred to as the "swine flu," has spread around the globe and infected hundreds of thousands of people. during the first few days after the initial outbreak in mexico, extensive media coverage together with a high degree of uncertainty about the transmissibility and mortality rate associated with the virus caused widespread concern in the population. the spread of an infectious disease can be strongly influenced by behavioral ... | 2009 | 19997505 |
| the severity of pandemic h1n1 influenza in the united states, from april to july 2009: a bayesian analysis. | accurate measures of the severity of pandemic (h1n1) 2009 influenza (ph1n1) are needed to assess the likely impact of an anticipated resurgence in the autumn in the northern hemisphere. severity has been difficult to measure because jurisdictions with large numbers of deaths and other severe outcomes have had too many cases to assess the total number with confidence. also, detection of severe cases may be more likely, resulting in overestimation of the severity of an average case. we sought to e ... | 2009 | 19997612 |
| the enigma of the h1n1 flu: are you ready? | this flu season, health care providers must be prepared to treat patients who have the seasonal flu and also those who have contracted a novel strain of the h1n1 influenza virus. although h1n1 flu is sometimes incorrectly called "swine flu," the virus is transmitted from person to person; it cannot be contracted from pigs or from eating pork products. symptoms of the h1n1 flu include fever, chills, nausea, vomiting, body aches, lethargy, and fatigue, which usually appear in rapid succession. peo ... | 2009 | 19961971 |
| "flu" before "swine"? | 2009 | 19960729 | |
| [h1n1 influenza pandemic of 2009]. | 2009 | 20067043 | |
| [impact of pandemic h1n1 2009 influenza virus on critical care in australia: a single centre case series]. | in late may 2009, an outbreak of the novel swine - influenza a virus (h1n1) was identified in the southern hemisphere. we describe the clinical and epidemiologic characteristics ofpatients infected with h1n1 requiring intensive care (icu) admission at a sydney university hospital. | 2009 | 20070030 |
| [hemagglutination inhibition test for retrospective diagnosis of avian influenza in mammals]. | to compare usage of native and formalinized erythrocytes from different animal species in hemagglutination inhibition (hi) test for detection of level of specific antibodies to h5n1 influenza virus in sera of mammals. | 2009 | 20063797 |
| h1n1: a mexican perspective. | in april this year, a new influenza virus of swine origin emerged in mexico and spread rapidly around the world. as the northern hemisphere winter flu season kicks off, laura vargas-parada reports on the measures that mexico is taking to combat the h1n1 pandemic. | 2009 | 20064360 |
| pandemic influenza a (h1n1) 2009 in malaysia--the next phase. | 2009 | 20058566 | |
| "swine" flu: a new challenge. | 2009 | 20058722 | |
| pigs, people and now pets. | 2009 | 20054914 | |
| evaluation of the efficacy and cross-protectivity of recent human and swine vaccines against the pandemic (h1n1) 2009 virus infection. | the current pandemic (h1n1) 2009 virus remains transmissible among humans worldwide with cases of reverse zoonosis, providing opportunities to produce more pathogenic variants which could pose greater human health concerns. to investigate whether recent seasonal human or swine h1n1 vaccines could induce cross-reactive immune responses against infection with the pandemic (h1n1) 2009 virus, mice, ferrets or mini-pigs were administered with various regimens (once or twice) and antigen content (1.77 ... | 2009 | 20037716 |
| [swine flu (h1n1) pandemic: challenges and repercussions for the health care system]. | 2009 | 20038387 | |
| e14-f55 combination in m2 protein: a putative molecular determinant responsible for swine-origin influenza a virus transmission in humans. | the species-specific signatures of the swine-origin influenza a (h1n1) virus (s-oiv), which caused the current influenza pandemic, have not been well defined. by comparing the protein sequences of s-oivs with those of swine, avian and human influenza viruses, we found that that almost all human iavs and those causing influenza pandemics, including the 2009 s-oivs, had a combination of glutamic acid (e) residue at position 14 and phenylalanine (f) residue at position 55 in their m2 protein, while ... | 2009 | 20029615 |
| [swine influenza virus: evolution mechanism and epidemic characterization--a review]. | pigs may play an important role in the evolution and ecology of influenza a virus. the tracheal epithelium of pigs contain both sa alpha 2,6 gal and sa alpha 2,3 gal receptors and can be infected with swine, human and avian viruses, therefore, pigs have been considered as an intermediate host for the adaptation of avian influenza viruses to humans or as mixing vessels for the generation of genetically reassortant viruses. evolution patterns among swine influenza viruses including evolution of ho ... | 2009 | 20030049 |
| swine flu's unsportsmanlike conduct. athletes are trying to avoid h1n1. but must friendly gestures lose out? | 2009 | 20027933 | |
| [743 new york emergency room rotation under the threat of swine flu]. | 2009 | 20027972 | |
| making the h1n1 (swine) flu vaccine mandatory for hospital employees. | 2009 | 20043367 | |
| too early to declare h1n1 swine flu pandemic over, says who chief. | 2009 | 20044393 | |
| pandemic swine flu 2009. | 2009 | 20042043 | |
| outbreak of 2009 pandemic influenza a (h1n1) at a new york city school. | in april 2009, an outbreak of novel swine-origin influenza a (2009 h1n1 influenza) occurred at a high school in queens, new york. we describe the outbreak and characterize the clinical and epidemiologic aspects of this novel virus. | 2009 | 20042754 |