Publications

[role of catalase in shigella flexneri and s. sonnei survivability in phagocytes].		1981	7024743
studies on virulence of shigella flexneri. protective effect of outer membrane proteins.	groups of mice were immunized intraperitoneally with proteins isolated from outer membrane of virulent strain of shigella flexneri 3a and its avirulent variant. all the animals were found to survive challenge with ld100 of virulent sh. flexneri 3a. similar protective effect against challenge with sh. flexneri 3a gave also immunization of mice with outer membrane proteins isolated from sh. flexneri of other serotypes (2a, 4a, 6, and x) and from escherichia coli, hafnia alvei and shigella sonnei.	1981	7025793
a chronic carrier of trimethoprim-sulphamethoxazole-resistant shigella flexneri serotype 1.		1981	7026229
shigellosis in infants and children.		1981	7026439
[rare case of mixed infection (tick-borne encephalitis, typhoid, dysentery and opisthorchiasis)].		1981	7026892
[relation of dysentery drug therapy to the development of antibiotic resistance in shigella].		1981	7027914
[group of derepressed pkmr plasmids found in wild strains of shigella].	a group of derepressed (drd) r plasmids was identified in 3 clinical isolates of shigella, i. e. sh. flexneri 1b, sh. flexneri 3c and sh. sonnei resistant to ampicillin (ap), streptomycin (sm), tetracycline (tc), chloramphenicol (cm), kanamycin (km) and sulfathiazole (su). the plasmids were designated as pkmr 202-2 (sm, tc, cm, km, su), pkmr 203-3 (ap, tc, cm, su), pkmr 204--2 (sm, km, su), pkmr 204-3 (ap, sm, cm, km, su), pkmr 204-4 (ap, sm, km, su), pkmr 204-5 (km, su), pkmr 204-6 (ap, sm, tc, ...	1981	7027918
[radioprotective properties of shigella antigens].		1981	7029609
[outcomes of acute dysentery].		1981	7029905
[formation of l-forms of shigella flexneri and shigella sonnei in vitro].		1981	7029982
endemic enteric disease in vervet monkeys.	comprehensive bacteriological investigation indicates shigellae as the probable aetiological bacteria in one endemic enteric disease situation. one species and four serotypes have been detected. in vitro antibiotic sensitivity spectra have been determined. epidemiology, pathology and pathogenesis in relation to the experimental animal situation and experimental results are considered. a rationale for treatment and control is suggested.	1981	7031245
enhancement of gas production in a strain of shigella flexneri serotype 6 by r plasmids.	the introduction of four different r plasmids into an aerogenic strain of shigella flexneri serotype 6 resulted in changes in the amount of gas produced and in the range of carbohydrates from which this occurred. the possible causes of these changes and their implications for bacterial identification are discussed.	1981	7031253
[mechanism of adhesion of shigella to the intestinal mucosa].		1981	7032161
[nature of the epidemic process in sonne and flexner dysenteries and the causes of its induction].	a comparative study of the epidemic process in sh. sonnei and sh. flexneri dysentery in different regions of the ussr revealed that the morbidity level of sh. sonnei dysentery changed simultaneously in the regions under study at intervals of 2-3 years. sh. flexneri dysentery showed morbidity rises occurring at intervals 6-8 years, and their occurrence did not coincide with the periods of elevated morbidity in sh. sonnei dysentery. the data obtained in the cohort analysis and in the study of recu ...	1981	6457474
shigella septicaemia following renal transplantation.	two patients are described who developed septicaemia with shigella flexneri following renal transplantation. pre-operative screening had not identified either patient as a chronic carrier of shigella sp. the acute management and problems posed by unrecognized carriers amongst patients undergoing transplantation in areas of the world where shigella is endemic, are discussed.	1980	7022421
[mapping of mutations in genes of flexner shigellae controlling the synthesis of certain ribosomal proteins and study of the effect of these mutations on bacterial virulence].	the study, carried out to localize the mutations which determine resistance to spectinomycin and neamin, has revealed that in sh. flexneri the genes of the str -- s area and located in the order similar to the order of their location in e. coli k12: spc a -- nea a -- str a -- nea b. mutation in spc a gene was shown to have no influence on the capacity of the shigellae for causing keratoconjunctivitis, whereas nea a mutation resulted in the complete loss of virulence; in str a and nea b mutations ...	1980	7013375
[shigella interaction with immune enterocytes].	the immunity induced in rabbits by oral immunization with boivin shigella polyantigen results in activation of enterocytes: hypertrophy and dilatation of the golgi apparatus and endoplasmic reticulum, increase in the number of sizes of primary and secondary lysosomes. resistance of the immune enterocytes to shigella is manifested in a decreased number of bacteria able to penetrate the cytoplasm, the absence of lysis of heterophagosome membrane surrounding the organisms, and the lack of fusion of ...	1980	7011272
fatal shigella dysentery complicated by toxic megacolon and bone marrow aplasia in a patient with chronic granulocytic leukemia in remission.	a patient with philadelphia positive chronic granulocytic leukemia in clinical remission is described, who developed shigella dysentery complicated by fatal toxic megacolon, pancytopenia and bone marrow aplasia. the difficulties of differential diagnosis between active ulcerative colitis and shigella dysentery and problems relating to the management of these two disorders are discussed. leukocyte function in chronic granulocytic leukemia and its role in infection in these patients is also briefl ...	1980	7009362
artificial carbohydrate antigens: synthesis of rhamnose trisaccharide and disaccharide haptens common to shigella flexneri o-antigens.		1980	6987247
artificial carbohydrate antigens: the synthesis of a tetrasaccharide hapten, a shigella flexneri o-antigen repeating unit.	the 8-methoxycarbonyloctyl glycoside of the tetrasaccharide hapten, o-alpha-l-rhamnopyranosyl-(1 leads to 2)-o-alpha-l-rhamnopyranosyl-(1 leads to 3)-o-alpha-l-rhamnopyranosyl-(1 leads to 3)-2-acetamido-2-deoxy-beta-d-glucopyranoside and the trisaccharide glycoside 8-methoxycarbonyloctyl o-alpha-l-rhamnopyranosyl-(1 leads to 3)-o-alpha-l-rhamnopyranosyl-(1 leads to 3)-2-acetamido-2-deoxy-beta-d-glucopyranoside were synthesized by sequential koenigs-knorr reactions from monosaccharide units. the ...	1980	6988076
corneal ulceration due to shigella flexneri.	shigella keratitis with ulceration is a rare occurrence with only four previous reports in the literature. corneal ulceration appears to be characteristically superficial with a predilection for the inferior cornea. in the case reported here, resolution of ulceration occurred with the use of gentamicin and chloramphenicol, following a poor response to sulfacetamide. experimental evidence strongly suggests that the course of infection is usually self-limited but that corneal scarring is a common ...	1980	6988565
[state of immunogenesis in different methods of treating acute dysentery].		1980	6988643
[sensitivity to antibacterial preparations of the causative agents of intestinal infections in transcarpathia. ii. shigella and enteropathogenic escherichia].		1980	6988685
effect of shigella flexneri endotoxin on ureagenesis and liver ultrastructure in rabbits.		1980	6991279
clinicopathological conference: eleven month old child with bloody diarrhea.		1980	6994225
[therapeutic effectiveness of nevigramon in the complex treatment of acute dysentery].		1980	6994350
cross-reactivity of major outer membrane proteins of enterobacteriaceae, studied by crossed immunoelectrophoresis.	outer membrane fractions were prepared from 11 bacteria in the family enterobacteriaceae: escherichia coli serotypes o1k-, o4k2, o26k60, o75k-, and o111k58, shigella flexneri, salmonella typhimurium, klebsiella pneumonia, serratia marcescens, proteus vulgaris, proteus mirabilis, and providencia stuartii. all strains studied were found to contain one non-peptidoglycan-bound, heat-modifiable outer membrane protein, and one or two peptidoglycan-associated major outer membrane proteins in the 27,000 ...	1980	6995435
resistogram typing of shigella flexneri.	fifty strains of shigella flexneri from sporadic cases of bacillary dysentery were tested for their resistance to 7 antibacterial compounds. sixteen combinations or results were obtained and these were used to form resistograms for the bacteria. the results agreed well with those of serotyping.	1980	6996117
[multiplication dynamics in a pulmonary model of sh. sonnei and sh. flexneri differing in virulence].	the most essential differences in the time course proliferation of virulent and a virulent sh. sonnei and sh. flexneri strains in the pulmonary model were found to become, manifest 3--6--9 hours postinoculation. in contrast to the avirulent sh. flexneri strains smooth type, with its intensive elimination, the avirulent sh. sonnei strains in phase i were preserved on their primary infective level during these hours, and their subsequent elimination was slower. the differences thus revealed seem t ...	1980	6996394
reiter's syndrome in a five-year-old girl.		1980	6996691
a new nitrogen base 5-hydroxycytosine in phage n-17 dna.		1980	6997086
[formation of iron-binding metabolites by bacteria of the enterobacteriaceae family].	the capacity of enterobacteriaceae strains cultivated in a synthetic medium for the biosynthesis of catechols and hydroxamates has been studied. among the strains under study all strains of the genera salmonella (8 strains), escherichia (102 strains), citrobacter (5 strains), enterobacter (2 strains), serratia (1 strain) synthesize catechols. in the genus shigella (128 strains) all sh. flexneri serovars (79 strains) do not synthesize catechols, other representatives of this genus synthesize iron ...	1980	6998212
[dissemination of bdellovibrio acteriovorus in animals and their interaction with the agents of acute intestinal infections].	cows, horses, pigs and ducks have been found to contain bdellovibrio bacteriovorus in their intestine and to constantly excrete them with feces into the environment. these microorganisms have not been detected in the feces of man, white mice, frogs and fish. bdellovibrio, if introduced together with shigella or after them, prevent the development of keratoconjunctivitis in some of the rabbits. no manifestations of the lytic activity of bdellovibrio in relation to salmonella and vibrio cholerae h ...	1980	6998228
[live vaccines for the prevention of intestinal infections].	shigella live vaccine was applied orally, four or five times, to 12000 children, aged between one and seven years. morbidity in the immunised group was 3.5 times as high (9.3 times after boostering) as that in the non-immunised control group. immunity could be provided for four months, and it was strictly specific of types. results so far obtained from animal experiments, such as pulmonary and kerato-conjunctival tests on mice, are likely to support the idea of developing a combination vaccine f ...	1980	6998403
[local immune response in rabbits following enteral immunization with live attenuated bacterial enterobacteriaceae vaccines].	streptomycin-dependent and inactivated shigella flexneri 2a and shigella sonnei strains were intra-intestinally applied to rabbits for immunisation. rosette and plaque tests and well as indirect haemagglutination gave short-time secretion of low titres of specific copro-antibody, following monovaccines and bivaccines. high titres of secretory antibody were induced, depending on doses, by re-immunisation. no antigen competition was established. the localised immune response caused by shigella liv ...	1980	6998404
detection of r plasmids with a restrictive effect on phage-bacteria shigella flexneri and shigella sonnei systems.		1980	6998412
randomized trial of high- and low-dose ampicillin therapy for treatment of severe dysentery due to shigella dysenteriae type 1.	to establish optimal therapy for severe dysentery due to shigella dysenteriae type 1 and shigella flexneri, we compared in a prospective randomized trial two oral ampicillin doses (50 and 150 mg/kg per day) in 57 children and 39 adults in dacca, bangladesh. clinical failure did not occur in either group, indicating that conventional doses need not be increased even in severe disease. among children 3 years of age or under, bacteriological relapses tended to be more frequent in the low-dose group ...	1980	6999981
possible role of colonic content in the mucosal association of pathogenic shigella.	association of shigella flexneri to cecal membrances was studied by incubating the pathogen with cecal slices of germfree mice. the slices were first incubated with stool supernatants from germfree, shigella-monocontaminated, and conventional animals. quantitation of shigellae in homogenates of treated slices revealed an increase of organisms only in those slices exposed to contaminated stool supernatants.	1980	7000704
antibody-dependent cell-mediated antibacterial activity: k lymphocytes, monocytes, and granulocytes are effective against shigella.	normal human peripheral blood lymphocytes, monocytes, and granulocytes decreased the viability of shigella flexneri in vitro in cooperation with heat-inactivated rabbit hyperimmune anti-shigella antisera. purified k and t lymphocyte populations used before the removal of fc receptor-bearing cells were effective in this antibody-dependent complement-free system. in contrast, b lymphocytes and t lymphocytes from which fc receptor-bearing cells were removed exhibited no activity. in the absence of ...	1980	7000906
isolation and characterization of minicell-producing mutants of shigella spp.	minicells are small, anucleate cells resulting from aberrant cell divisions at the polar ends of bacilli. we have isolated minicell-producing mutant strains of shigella flexneri 2a (mc-i) and shigella dysenteriae 1 (mc-v) after mutagenesis with n-methyl-n'-nitro-n-nitrosoguanidine. microscopically, broth cultures of mc-i and mc-v were found to contain free minicells, normal cells, and filamentous cells with polar, attached minicells. both strains retained their ability to provoke keratoconjuncti ...	1980	7002790
protection against keratoconjunctivitis shigellosa induced by immunization with outer membrane proteins of shigella spp.	active immunization of guinea pigs and rabbits with outer membrane proteins (omp) isolated from shigella flexneri 3a and shigella sonnei phase i protected the animals against keratoconjunctivitis shigellosa induced with the homologous or heterologous strain. protection was also achieved in rabbits after passive immunization with anti-omp immune serum. active immunization with lipopolysaccharide of s. flexneri 3a did not protect rabbits against keratoconjunctivitis shigellosa.	1980	7002794
contrasting epidemiology of shigellae dysenteriae and shigellae flexneri, dacca.		1980	7003832
[etiological structure of dysentery in the verkhnebureya district, khabarovsk territory, in 1974-1976].		1980	7004000
[enteric dysentery vaccines and their effectiveness in a rabbit intestinal loop model. i. the residual virulence of attenuated vaccinal strains of shigella administered into the intestinal loops].	virulent sh. flexneri strain 2a, sh. sonnei strain, attenuated sh. flexneri vaccine strain 2a 516m, and sh. sonnei vaccine strain 6s (isolated by yu. a. belaya), as well as streptomycin-dependent sh. flexneri strain 2a 1605/3 (isolated by v. v. sergeev) were introduced into the ligated loops of the rabbit ileum. the use of light and immunofluorescent microscopy, the measurement of the volume of the fluid in the intestinal loops and the quantitative inoculation of their contents resulted in revea ...	1980	7004003
[shigella flexneri mutation giving rise to the appearance of fosfomycin-resistant avirulent forms with disordered carbohydrate utilization].	the present work analyzes pt44 mutation in sh. flexneri resulting in the appearance of the following phenotypical properties: resistance to phosphomycin, avirulence, pleiotropic disturbances in carbohydrate utilization. the data provided by the biochemical and genetic analysis have indicated that pts44 mutation occupies the region between purc and ptsi loci on the chromosome of sh. flexneri. merodiploids containing the mutant allele pts44 and the plasmid including purc-ptsi-ptsh genes from e. co ...	1980	7004011
[certain features of the boivin antigens of streptomycin-dependent sh. flexneri 2a strains differing in immunogenicity].		1980	7004013
[characteristics of attenuated immunogenic mutants of shigella flexneri selected from phosphomycin-resistant clones].	sh. flexneri mutants no. 2a, resistant to phosphomycin (25 microgram/ml), differ in their fermentability in respect to glucose, mannitol, mannose and fructose. the mutants fall into 7 groups by this characteristic. all the resistant mutants, irrespective of the type of hydrocarbon fermentation, have lost their ability of causing keratoconjunctivitis. the decreased virulence of the phosphomycin-resistant mutants is linked with the loss of their penetration properties, although their adhesiveness ...	1980	7004017
[chromosomal transformation of escherichia coli by shigella flexneri dna].		1980	7004023
effects of endotoxin from different bacteria on ovum transport in rabbits.		1980	7004496
yersinia pseudotuberculosis infection in a group of macaca fascicularis.	diarrheal disease associated with abortions and stillbirths occurred in a group of 42 macaca fascicularis. the group was composed of wild-caught adults and their colony-born offspring housed in a half-acre cage. thirteen adult females and 1 infant male were affected. all 14 monkeys had diarrhea and all 9 pregnant females either aborted or had a stillbirth. yersinia pseudotuberculosis was isolated from 7 animals. in addition, y enterocolitica was isolated from 1 monkey and shigella flexneri type ...	1980	7005202
faecal excretion of entero-pathogens in a pakistani family returning to the u.k. after a visit to rawalpindi.	the family consisted of two parents and five children. while the father remained in cardiff, the mother and all the children visited rawalpindi, pakistan, for 6 weeks to stay with relatives. travel was by flight from heathrow airport to pakistan and by a short road journey to rawalpindi. mrs m. - the mother - as a guest, did no cooking on the holiday. the house which they were living in had a piped water supply, thought to be treated. there was no flush toilet but a commode was available and was ...	1980	7005329
[serum creatine phosphokinase, got, and gpt activity in different types of infectious diseases in monkeys].	an increase in creatine phosphokinase (cpk) activity as well as a decrease in activities of aspartate aminotransferase (aat) and alanine aminotransferase (alt) were observed in monkey blood serum under conditions of experimental infection of the animals with dysentery. contrary to the non-immunized animals, the activity of cpk was increased but the activities of aat and alt were unaltered in blood serum of the immunized monkeys. estimation of the enzymatic activity might be used for diagnosis of ...	1980	7006207
survival of shigellae in soil.	the survival of four shigella strains in soil (sh. sonnei, sh. boydii, sh. flexneri and sh. dysenteriae) was studied under various conditions. their survival period was tested in two different types of sterile soil at 18-20 degrees c and in one type of soil at 4 and 37 degrees c. this latter type of soil, after enrichment with casaminoacids or (nh4)2hpo4 was also used for testing again the survival of the strains at 18-20 degrees c. though the initial number of the inoculated microorganisms was ...	1980	7006270
endotoxin-induced uveitis in the rat.	experimental studies of ocular inflammation induced by endotoxin have been performed almost exclusively in rabbits. although the rat has been considered refractory to both the systemic and local effects of endotoxin, the present study has shown that intravitreal injection of endotoxin evoked a characteristic acute inflammatory response which was reproducible and dose-dependent. in addition, a consensual ocular response in the control eye occurred which was less severe but also dose-dependent. pr ...	1980	7006439
resistance to trimethoprim and other antibiotics in shigellae isolated in the province of ontario.	antimicrobial susceptibility determinations for three commonly used and seven seldom used antibacterial drugs against 482 strains of shigellae isolated in ontario during 1977 and 1978 were carried out. resistance to the first-line treatment drugs, ampicillin and tetracycline, occurred in 20.5 and 39.2% of strains, respectively. the emergence of trimethoprim-sulfamethoxazole resistance was noted for the first time in 3.2% of the strains in 1978. all strains retained their susceptibility to gentam ...	1980	7006767
structural studies on shigella flexneri serotype 6 core region.	the core structure of shigella flexneri serotype 6 has been investigated. the methods used in these studies involved methylation analysis, periodate oxidation, smith degradation and enzymic modifications of core oligosaccharides isolated from two smooth strains and four rough mutants. as a result the complete core region was established (formula: see text) where dgalp = d-galactopyranose, dglcp = d-glucopyranose, l alpha dhepp = l-glycero-d-mannoheptapyranose, docla = 3-deoxy-d-manno-octulosonic ...	1980	7007048
[effect of antibacterial therapy on regeneration of large-intestinal mucosa in dysentery].		1980	7008234
shigellosis in the marshall islands: epidemiologic aspects of an outbreak.	an outbreak of diarrheal illness caused by shigella flexneri 1b and associated with 11 deaths occurred in the marshall islands during june and july 1977. a house-to-house survey on majuro indicated an attack rate of 6.2%. neither the survey nor a case-control study uncovered a common source of exposure on majuro, and it is believed that transmission was mainly person-to-person. socioeconomic factors, type of water supply, distance to municipal water supply, and type of sanitary facility could no ...	1980	7386724
[antibiotic resistance of shigella strains isolated in cádiz (author's transl)].	the incidence of shigellosis at the residencia sanitaria fernando zamacola (cáciz, spain) and the antibiotic sensitivity of 94 strains of shigella sonnei and 40 strains of shigella flexneri, isolated during the year 1979, has been studied taking into account the present status of strain resistance to the major antibiotics. three epidemic bouts of shigellosis were detected: one in february by shigella sonnei (16 cases), and two others in august-september and november due to shigella flexneri (43 ...	1980	7464328
salmonella typhi r-plasmids in hungary.	the antibiotic sensitivity of 4095 salmonella typhi strains isolated in hungary from january, 1974 to june 1979, was tested. twelve strains derived from one patient and seven chronic carriers were resistant to antibiotics due to r-plasmids. one of the s. typhi strains carried two r-plasmids and the change in the phage type of this strain was caused by one of the plasmids. r-plasmid of the same restrictive property was found in an escherichia coli strain isolated from the faeces of the correspond ...	1980	7468321
high frequency of hla-b27 and reiter's syndrome in navajo indians.	eighteen cases of reiter's syndrome were found in a population of approximately 6,000 navajo indians. the phenotype frequency of hla-b27 in this population was found to be 36%. the area in which these people live is endemic for shigellosis, shigella flexneri being the most common species isolated. presumably the high frequency of hla-b27 and shigella infections account for the high incidence and prevalence of reiter's syndrome in this population.	1980	7205829
liposomes as vehicles for vaccines.	lipid a from shigella flexneri lps, or acylated derivatives of muramyl dipeptide (mdp), were incorporated into the lipid bilayer of liposomes to enhance the adjuvanticity of the liposomes in rabbits. liposomes containing lipid a induced antibodies against lipid a, phosphocholine, phosphatidylcholine, and sphingomyelin. lipid a was resolved into eight fractions, some of which did, and others of which did not, induce antibodies against liposomes. anti-liposome antibodies also were induced (in the ...	1980	7208512
a study on experimental keratoconjunctivitis shigellosa.		1980	7035740
bacteriological and epidemiological approaches to the prophylaxis of enteric infection. vi. in vitro studies on the mechanism of acquired resistance to shigella flexneri infection (1).		1980	7035741
stimulation of prostaglandin e production by bacterial endotoxins in cultured human synovial fibroblasts.	e coli, shigella, salmonella, and cholera endotoxins stimulated prostaglandin e (pge) production by cultured human synovial and foreskin fibroblasts. the minimal effective dose of shigella endotoxin was 2 micrograms/ml and a maximal response was observed at 10 micrograms/ml. pge stimulation was first detected 7 hours after addition of cholera endotoxin. stimulation by shigella endotoxin of both pge and hyaluronic acid production was inhibited by indomethacin and aspirin. the present results sugg ...	1980	6157394
[change in the nonesterified fatty acid makeup of shigella flexneri no. 15172 type 3a in the process of passage on developing chick embryos].	composition of nonesterified fatty acids/nefaj from shigella flexneri was similar to that from other gram-negative bacteria of the enteritic group. at the same time, nefa of the dysenteric bacteria contained comparatively high amount of branched and cyclopropane-bearing fatty acids. adaptation of shigella flexneri in the medium of developing chicken embryo led to a distinct increase in total nefa content as well as of cyclopropane-bearing and saturated fatty acids in the bacteria and to a decrea ...	1980	6245536
genetic and physical evidence for plasmid control of shigella sonnei form i cell surface antigen.	virulent shigella sonnei synthesize a surface antigen (form i) which appears to be one of several requirements needed for this host to invade epithelial cells. upon restreaking on agar media, form i cells readily and irreversibly generate form ii cells that lack the form i antigen. all form ii cells are avirulent. plasmid deoxyribonucleic acid of form i and ii cells of four different s. sonnei isolates, obtained from different areas of the world, was analyzed by agarose gel electrophoresis. a la ...	1980	6249756
isolation of two protein-free and chemically different lipopolysaccharides from bordetella pertussis phenol-extracted endotoxin.	endotoxin prepared from several bordetella pertussis strains in both immunological phases i and iv gave two lipopolysaccharide peaks (lps-i and lps-ii) when analyzed on hydroxylapatite columns in a phosphate buffer containing 0.1% sodium dodecyl sulfate; these lipopolysaccharides, present in the ratio of 2:3, are true endotoxins by both chemical and biological criteria. endotoxins isolated from escherichia coli, salmonella typhimurium, and shigella flexneri gave single lipopolysaccharide peaks w ...	1980	6249793
neutron irradiation of bacteria in the presence and absence of secondary charged-particle equilibrium.		1980	6251509
[isolation and characteristics of polymyxin-resistant mutants of shigella flexneri].	some characteristics of s. flexneri 2a mutants resistant to various concentrations of polymyxin m were studied. the data indicate that mutations resulting in low (50 microgram/ml) and high (300 microgram/ml) levels of the antibiotic resistance were determined by different genes. polymyxin resistance led to changed permeability of the outer membrane with respect to detergents and some antibiotics, such as aminoglycosides, penicillins, chloramphenicol and amphotericin b but did not change sensitiv ...	1980	6252826
[shigella: microbiological aspects and incidence in our environment].		1980	6755638
monocyte function in rheumatoid arthritis.	monocytes derived from peripheral blood of patients with rheumatoid arthritis (ra) had a marked defect in their bactericidal activity against staphylococcus albus and listeria monocytogenes; whereas the phagocytic capacity of monocytes from ra patients for both staph. albus and shigella flexneri was similar to that of monocytes from healthy subjects. there were no significant differences between the patient and control groups with regard to antibody dependent cellular cytotoxicity (adcc) of mono ...	1980	6769149
[isolation of metal-resistant shigella flexneri and its application to experimental animal infection. 1. isolation of cd and zn resistant strain and its characters (author's transl)].		1980	6770010
[isolation of metal resistant shigella flexneri and its application to experimental animal infection. 2. comparison of biochemical and serological characters among the original, the cd, zn resistant and the tc resistant strain (author's transl)].		1980	6772717
[features of the infectious process caused by shigellae of different species].		1980	6778021
synthesis and utilization of siderophores by shigella flexneri.	strains of shigella flexneri secrete a hydroxamate-type siderophore when grown in low-iron media. this hydroxamate appears to be identical with aerobactin, a siderophore synthesized by aerobacter aerogenes. in contrast to other enteric bacteria, s. flexneri did not produce detectable phenolate siderophores, although it could utilize an exogenously supplied phenolate.	1980	6447691
[tendencies in the epidemic process of dysentery in ryazan].	in shigellosis caused by sh. sonnei and sh. flexneri the epidemic process was found to have considerable difference in the tendencies and pace of its development. shigellosis which dominated in the etiological structure at the period following 1966 was dysentery caused by sh. sonnei; it showed the tendency towards a decrease in morbidity rate. dysentery caused by sh. flexneri was second in respect to the frequency of its occurrence after 1966 and showed the tendency towards increase. the simulta ...	1980	6449121
[use of data on shigella contamination and immunity indices for studying the activity of the epidemic process in dysentery].	the comparative study of the monthly distribution of characteristics indicating the levels of contamination with sh. sonnei and sh. flexneri separately, as well as the seasonal dynamics of the corresponding antibodies, in the years with high and low morbidity levels has been made with the use the indirect hemagglutination test. the possibility of using these characteristics for the evaluation of the activity of the epidemic process in dysentery caused by sh. sonnei is shown.	1980	6449816
time in chemo-immunotherapy models: an absolute or a relative variable? lessons from the levamisole experience.	an analysis is presented of the findings from the available studies in several cancer models, where 2.5-20 mg/kg levamisole was given in combination with different types of cytostatic drugs. it appears that in chemo-immunotherapy experiments it may be preferable to measure time variables (increase in life span, timing of chemotherapy and of immunotherapy) as a per cent of the median survival time of the untreated controls instead of using time as an absolute measure (in days). as regards the stu ...	1980	551097
time--a neglected aspect of psychiatric treatments.	this review attempts to deal with the complex issues involved in the time to heal, with special reference to psychological processes. the questions of convalescence and relapse in organic medicine are explored and extrapolated to psychiatric processes. the concept of a latency period of change in treatment outcome is discussed with reference to both less complicated reactive states as well as highly charged neurotic processes. the problems of recognizing slow but perceptible change and separatin ...	1980	283799
children in cars. results of an observational study in new zealand.	if children under the age of 14 years were adequately restrained while travelling in cars, many deaths and injuries could be prevented. seventeen thousand, one hundred and fifty-five children under 14 years of age were observed in cars. only 20 percent overall were appropriately restrained. a breakdown into different age groups showed that the percentage of children who were adequately restrained varied with ages: less than six months 54 percent; six months-four years 18 percent; five-seven year ...	1980	294525
mesothelioma on the coast of brittany, france.		1980	294184
preventing the birth of a handicapped child.		1979	243247
measurement of functional capacity with visual analogue scales.	the value of three visual analogue scales for measuring aspects of functional capacity was assessed in 22 patients with rheumatoid arthritis receiving long-term treatment. a scale in which patients were allowed to choose a function which was a particular problem gave the best results, with more severe initial impairment and greater change with treatment. this scale was as useful as pain in assessing the result of treatment.	1979	414343
[preclinical diabetes mellitus in children].		1979	414321
[roentgeno-morphologic changes in the bones of battered children].	the demonstrated characteristic bone lesions should raise the suspicion of "battered child syndrome". the important role of the radiologist is stressed.	1979	1457479
the relationship between genetics and environment in the pathogenesis of rheumatic diseases.	major developments have taken place to further our understanding of the relationship between genetics and the environment in the pathogenesis of rheumatic disorders. the association between hla markers and human disease is becoming clearer. for instance, hla-drw4 frequently occurs in patients with rheumatoid disease, and penicillamine and gold toxicity are seen most often in patients with hla-drw2 or drw3. antisera to b alloantigens help define the genetic differences between systemic lupus eryt ...	1979	18748470
macrophage fatty acid composition and phagocytosis: effect of unsaturation on cellular phagocytic activity.	in order to manipulate the physical properties of the macrophages membrane, methods were developed which potentiated the incorporation of exogenously supplied fatty acids into membrane lipids. chromatograms of macrophages which were grown in the presence of a variety of fatty acids demonstrated that exogenously supplied unsaturated fatty acids (palmitoleic, oleic, elaidic, linoleic, linolenic and arachidonic acids) were readily incorporated into the cells and selectively altered the fatty acyl c ...	1979	374248
protein and ribonucleic acid syntheses in heat-damaged and heat-killed escherichia coli.	protein and ribonucleic acid (rna) syntheses were measured in both lethally injured and thermally damaged viable cells after heating at lethal temperatures. immediately after heating, cells were incubated in growth media containing either [14c]leucine or [3h]uracil. the labeled cells were subsequently treated with penicillin. viable cells were shown to lyse, and the intact nonviable cells were collected by centrifugation. the results showed that after heating, protein and rna synthesis were rein ...	1979	374390
non-random distribution of transduction termini in transductants from the integrated r plasmid, r100-1.	tra+ and tra- derivatives of drug resistance plasmid, r100-1, were isolated by phage p1 from an hfr donor with integrated r100-1 and then analyzed by complementation tests with tra- point mutants of flac. tra+ derivatives of r100-1 carrying tetracycline resistance alone and those carrying all six drug-resistrance genes could support transfer of tra- point mutants of flac except flac traj, whereas all of tra- derivatives of r100-1 failed to complement any one of tra- point mutants of flac. this s ...	1979	375027
shigella vaginitis: report of 38 patients and review of the literature.	thirty-eight cases of shigella vaginitis were identified in a retrospective review of records kept over the past 14 years. the cases of vaginitis were due to three subgroups of shigella. vaginitis varied in severity and duration, persisting for several months in some instances. in 47% of the cases, there was associated bloody vaginal discharge. only two children had diarrhea temporally associated with vaginitis, but six others had had diarrhea. many treatment modalities were used. systemic antib ...	1979	375177
nucleotide sequence of the transposable dna-element is2.	the complete sequence of the transposable dna element is2 in gal op-308:: is2 (i) has been determined. this element is 1.327 bp long. the integrated element is flanked by a five base pair long sequence duplication. the termini of is2 are not perfect inverted repeats, but a close approximation.	1979	375194
bacteremia caused by shigella flexneri.		1979	375454
[conjugative r plasmids of enterobacteria].		1979	375629
[interrelationship between the serum lysozyme level and the leukocyte count in sonne and flexner dysenteries].	interrelation between the level of the serum lysozyme and the count of the leucocytes, as well as the severity of the disease was found in testing of the peripheral blood of 133 patients with acute sonnei and flexner dysentery. it is recommended to use the lysozyme index in the clinical practice as one of the additional criteria for estimation of the severity of acute dysentery.	1979	375827
shigella serotypes in recent isolations at lucknow.		1979	376439
further studies on the activation of lymphocytes by endotoxin protein.	endotoxin protein, an outer membrane protein of gram-negative bacteria associated with lipopolysaccharide endotoxin, has been found to be a potent activator of lymphocytes. in the absence of t lymphocytes and macrophages, endotoxin protein can stimulate murine b lymphocytes to synthesize dna and produce antibodies of diverse specificities. this stimulation is greater than that obtained with two well known murine b cell activators, lipopolysaccharide endotoxin or ppd-tuberculin. splenic lymphocyt ...	1979	376715
quantitative determination of titers of anti-zona serum.	the titers of rabbit antiserum against isolated mouse zonae pellucidae were examined by several methods in connection with inhibitory effect on fertilization. the titers determined by zona precipitate, zona dissolution, indirect immunofluorescence and in vitro fertilization tests were 2(4), 2(1) to 2(4), 2(7) and 2(4), respectively. cytotoxic effect could not be detected from zona antibody. the indirect immunofluorescence was most sensitive for detection of zona antibody but did not represent th ...	1979	376778
composition of isolated edema fluid in cold-induced brain edema.	edema fluid isolated from cats with cold-induced brain edema was subjected to analysis of electrolyte content, enzyme activities, colloid osmotic pressure and the radioactivity of intravenously injected 99mtc-labeled albumin. the findings corroborate the essential features of vasogenic edema, such as its origin from the blood plasma, its rapid propagation into the white matter of the brain as contrasted with the delayed spread into gray matter, and its contribution to composition of cerebrospina ...	1979	376787
[storage of shigella flexneri with virulence preserved].		1979	376977