Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| neonatal shigellosis with bowel perforation. | 1985 | 3895181 | |
| a marker of early amacrine cell development in rat retina. | a monoclonal antibody, hpc-1, labels only amacrine and displaced amacrine cells in adult rat retina. reactivity with displaced amacrine cells was demonstrated by double-label immunofluorescence with hpc-1 and ganglion cell-specific reagents. hpc-1 antibody reacts with a polypeptide of apparent molecular weight 35,000. hpc-1 antibody labels migrating amacrine cells in late embryonic retinas. the results define cell-specific gene expression in relation to migration of one subclass of cns neurons. | 1985 | 3896407 |
| [acute alithiasic cholecystitis caused by infectious gastroenteritis]. | 1985 | 3897740 | |
| [structural characteristics of the remote interaction of shigella and salmonella with enterocytes of experimental animals]. | the electron-microscopic analysis of the adhesion of shigella and salmonella nonfimbriated strains to the surface of enterocytes of laboratory animals in vivo and in vitro has revealed the presence of structural links, whose formation occurs with the participation of the glycocalix of the interacting cells and the extracellular gel. | 1985 | 3898674 |
| plasmid-mediated drug resistance of shigellae in kuwait. | of 153 clinical isolates of shigellae examined, 64.7% belonged to shigella flexneri, 18.9% to sh. sonnei, 11.8% to sh. boydii and 4.6% to sh. dysenteriae. part of these isolates were resistant to sulfamethoxazole and streptomycin (88.2% each), ampicillin (66.7%), tetracycline (63.4%) and co-trimoxazole (43.1%), with levels of resistance (mic50 and mic90) being invariably high. resistance to three or more drugs (multidrug resistance) was seen in 77.8% of the isolates. all the 25 strains examined ... | 1985 | 3899007 |
| [interrelation of erythropoiesis and lymphopoiesis in experimental infectious processes and in viral leukemogenesis]. | interrelation of erythropoiesis and immune response was studied in mice of various lines infected with mycoplasma species, shigella flexneri 2a and rauscher leukemia virus (r-mlv). intensity of erythropoiesis was estimated by the endocolonization data of sublethally irradiated mice and 59fe incorporation, while immune reactivity--by generation of splenic antibody-forming cells in response to immunization with sheep erythrocytes. the inverse correlation between the ability of infectious agents to ... | 1985 | 3899611 |
| four cases of shigella septicemia in israel. | four cases of shigella septicemia are presented. in two children infection was caused by shigella flexneri and in two adults, who had underlying diseases which caused immunosuppression, by shigella sonnei and shigella schmitzi. all four patients responded to intravenous antibiotic therapy. in one patient the organism persisted in the stool, but was eliminated after oral administration of chloramphenicol. shigella septicemia is not uncommon and blood cultures should be obtained in suspected cases ... | 1985 | 3899637 |
| hla-b27 and clinical aspects of ankylosing spondylitis: results of prospective studies. | 1985 | 3899917 | |
| shigellosis (antibiotic resistance and transfer of r-factor). | 1985 | 3900357 | |
| [functional status of monocytes of the peripheral blood in dysentery]. | 1985 | 3900573 | |
| comparative biology of intracellular parasitism. | 1985 | 3900672 | |
| [effectiveness of thymalin and prodigiozan in the complex treatment of patients with dysentery]. | 1985 | 3901509 | |
| sensitivity to bile salts of shigella flexneri sublethally heat stressed in buffer or broth. | batch cultures of shigella flexneri m4243 were grown at 37 degrees c in broth to early stationary phase, washed, and heated at 50 degrees c in 0.1 m phosphate buffer (ph 7.0). cells were surface plated on a tryptic phytone glucose agar (tpga), tpga with 0.15 or 0.85% bile salts no. 3 (tpga-bs 0.15 or tpga-bs 0.85), or tpga with 0.25 or 0.50% sodium deoxycholate (tpga-dc 0.25 or tpga-dc 0.50). cells sampled after no heating produced colony counts on tpga-bs 0.85 or on tpga-dc 0.50 that were no mo ... | 1985 | 3901919 |
| localization and synthesis of the tumor protein oncomodulin in extraembryonic tissues of the fetal rat. | the calcium-binding protein oncomodulin, previously found only in tumors, has been detected during rat development. specific antisera to purified rat hepatoma oncomodulin (mw 11,500) were used to detect oncomodulin by radioimmunoassay (ria) and by avidin-biotin-peroxidase complex (abc) immunohistochemistry. using ria, oncomodulin was found to increase in placenta from below the limits of detection (2 ng/mg protein) on day 13 to approximately 25 ng/mg on day 16 of pregnancy, and to remain high th ... | 1985 | 3902538 |
| susceptibility and hla-b27 in post-dysenteric arthropathies. | a recent outbreak of bacillary dysentery in the netherlands revealed that, despite the close association of hla-b27 with post-dysenteric or reactive arthritis (rea), not even in one family did all hla-b27 positive patients infected by an arthritogenic bacterium, develop rea. this dissociation shows that additional factors beside b27 may determine susceptibility to rea. | 1985 | 3902627 |
| cyclosporine and partial liver allotransplants in a simplified rat model. | we designed a simplified rat model to assess the effects of cyclosporine (csa) on liver transplants. auxiliary liver grafts consisting of 20 per cent of the whole liver were supplied with portal inflow and the bile was drained into the stomach. the cuff technique was used routinely for both end-to-end and end-to-side venous anastomoses. the host liver was totally deprived of portal inflow. two inbred strains of rats, lew and f344, were used for isograft (lew----lew) and allograft (f344----lew). ... | 1985 | 3903301 |
| [functional status of the small intestine in dysentery sonnei and flexneri]. | 1985 | 3904028 | |
| decreased chemiluminescent associated phagocytic response of peripheral blood mononuclear cells to chlamydia trachomatis in patients with hla-b27+ anterior uveitis. | the chemiluminescent (cl) associated phagocytic response of peripheral blood monocytes to two serovars of chlamydia trachomatis, shigella flexneri and zymosan was assessed in a group of 26 patients with anterior uveitis (au). hla-b27+ patients with au, when compared to hla-b27- patients with au and appropriate controls, had a significantly decreased cl response to c. trachomatis but no difference between groups in the response to s. flexneri and zymosan. the decreased chemiluminescent (phagocyti ... | 1985 | 3904888 |
| identification and antigenic characterization of virulence-associated, plasmid-coded proteins of shigella spp. and enteroinvasive escherichia coli. | seven plasmid-coded polypeptides, designated a through g, were identified by two-dimensional nonequilibrium ph gradient electrophoresis of radiolabeled extracts from minicells of virulent shigella flexneri serotypes 2a and 5 and enteroinvasive escherichia coli o143. these polypeptides were deemed to be products of 140-megadalton (mda) virulence-associated plasmids because they were not synthesized in minicells which were not harboring a 140-mda plasmid or in minicells which were carrying an f la ... | 1985 | 3905608 |
| characterization of monoclonal antibodies against shiga-like toxin from escherichia coli. | three monoclonal antibodies, designated mab 16e6, mab 13c4, and mab 19g8, were produced which recognize shiga-like toxin (slt) from escherichia coli. all three monoclonal antibodies neutralized the cytotoxicity of e. coli slt and were able to immunoprecipitate intact labeled toxin with staphylococcus aureus protein a. the three antibodies were of the g1 heavy and kappa light chain classes. mab 16e6 bound to the b subunit of slt in western blots and also neutralized the lethality of the toxin for ... | 1985 | 3905611 |
| interspecific reconstitution of maltose transport and chemotaxis in escherichia coli with maltose-binding protein from various enteric bacteria. | in escherichia coli, the periplasmic maltose-binding protein (mbp), the product of the male gene, is the primary recognition component of the transport system for maltose and maltodextrins. it is also the maltose chemoreceptor, in which capacity it interacts with the signal transducer tar (taxis to aspartate and some repellents). in studies of the maltose system in other members of the family enterobacteriaceae, we found that mbp is produced by salmonella typhimurium, klebsiella pneumoniae, ente ... | 1985 | 3905762 |
| changing pattern of resistant shiga bacillus (shigella dysenteriae type 1) and shigella flexneri in bangladesh. | shigella dysenteriae type 1 (shiga bacillus) has made a dramatic comeback in bangladesh after 10 years when shigella flexneri was the dominant serogroup. whereas s. flexneri showed little increase in resistance to the commonly used antimicrobial agents--namely, trimethoprim-sulfamethoxazole (tmp-smx) and ampicillin-over the years, s. dysenteriae type 1 underwent rapid changes with regard to sensitivity pattern during the last two years. the first tmp-smx-resistant strain of s. dysenteriae type 1 ... | 1985 | 3905980 |
| [3-year study of shigellosis epidemic in rwanda, central africa. problems of public health and bacteriological aspects]. | since 1979, the lakes region (kivu in zaïre, western uganda, rwanda, burundi) has been stricken by a bacillary dysentery epidemic at s. dysenteriae type 1. supposed to be extinct since the 1950s., this bacillus has revealed a very noticeable virulence as well by the number of registered cases (524/100.000 in 1983 at ruhengeri-rwanda) as its fast break through. demographic density (from 400 to 600/km2) has played an important role and has facilitated the transition toward epidemicity. systematic ... | 1985 | 3906345 |
| [the nature of the cyclic course of the epidemiological process in dysentery]. | 1985 | 3907219 | |
| determination of nanogram quantities of vanadium in biological material by isotope dilution thermal ionization mass spectrometry with ion counting detection. | 1985 | 3907412 | |
| refined structure of alkaline phosphatase from escherichia coli at 2.8 a resolution. | the structure of alkaline phosphatase from escherichia coli has been determined to 2.8 a resolution. the multiple isomorphous replacement electron density map of the dimer at 3.4 a was substantially improved by molecular symmetry averaging and solvent flattening. from these maps, polypeptide chains of the dimer were built using the published amino acid sequence. stereochemically restrained least-squares refinement of this model against native data, starting with 3.4 a data and extending in steps ... | 1985 | 3910843 |
| n-methyl-l-glutamate synthase. | 1985 | 3911004 | |
| [study of the sensitivity of anaerobic bacteria using 2 dilution technics]. | we studied forty-seven anaerobic strains recovered from blood cultures or pus from deep infections over three months. antibiotic sensitivity was tested using two dilution techniques. for both, a standardized, controlled inoculum was used and strains with known susceptibilities were included. the first method consisted of dilution of antibiotics in schaedler broth and mic determination using microplates. in the second method, dilutions in wilkins-chalgren broth with 1.5 g/l agar and atb-api plate ... | 1985 | 3911155 |
| photochemical modifications of lac repressor: effect of effectors binding on tryptophan photooxidation. | 1985 | 3911222 | |
| [significance of isolating shigella under epidemiological circumstances]. | 1985 | 3911318 | |
| viruses and immune reactions in the liver. | the immunopathology of hepatitis b and delta virus infections of the liver are reviewed. it is clear there are several antigen/antibody systems of importance in acute and chronic hbv infection. antibodies to hbs, hb core/hbe and antibodies to dane specific determinants are involved in virus neutralisation. elimination of virus infected hepatocytes is dependent on recognition of viral determinants in association with hla proteins on the infected hepatocytes by cytotoxic t cells. the hla protein d ... | 1985 | 3911368 |
| the potential dependence of the intestinal na+-dependent sugar transporter. | the unidirectional influx of the lipophilic cation tetraphenylphosphonium (tpp+) into isolated intestinal epithelial cells exhibits a marked dependence on the membrane potential (delta psi) maintained by or experimentally imposed on these cells. by taking advantage of this fact, we have described a "crossover" procedure that allows the relative permeability of a cation and anion pair to be determined. measurements of such relative permeabilities permits diffusion potentials of defined magnitude ... | 1985 | 3911844 |
| [preventing bacillary dysentery with magnetized drinking water]. | 1985 | 3912058 | |
| [epidemiologic survey of an outbreak of food-borne bacillary dysentery]. | 1985 | 3912060 | |
| plasmid characterization of shigella spp. isolated from children with shigellosis and asymptomatic excretors. | strains of shigella dysenteriae type 1 and sh. flexneri isolated during 1981-82 from children with shigellosis and also from asymptomatic excretors were examined for drug resistance and for the presence of plasmids. shigella strains isolated from dysenteric children showed multiple plasmid bands. thirty-eight percent of the strains transferred the drug resistance factor(s), either partially or fully to a recipient escherichia coli k12 strain. plasmids in the molecular weight range from between 4 ... | 1985 | 3912364 |
| shigella flexneri bacteraemia in a patient with acquired immune deficiency syndrome. | 1985 | 3913261 | |
| studies on specificity of protection induced by immunization with outer membrane proteins of shigella. | immunization of c3h/hej mice with outer membrane proteins (omp) and with peptidoglycan associated proteins (pgp) isolated from shigella flexneri 3a and from shigella sonnei phase i protected the animals against lethal dose of homologous and heterologous bacteria and against various serotypes of shigella flexneri. neither of the protein preparations protected the animals against challenge with escherichia, klebsiella, citrobacter, salmonella, serratia, proteus and pseudomonas. omp preparations ho ... | 1985 | 3914866 |
| transfer of immunity by means of spleen cells from mice immunized with outer membrane proteins of shigella flexneri. | intraperitoneal immunization of mice with a single dose (5 micrograms) of outer membrane proteins (omp) of shigella flexneri was found to evoke in the spleen the appearance of cells by means of which immunity to lethal dose of shigella could be transferred into other mice. active cells capable of transferring immunity appeared in the spleen of the animals as early as on day 3, reached the strongest protective activity on day 4 and disappeared on day 8 after immunization. active cells from animal ... | 1985 | 3914867 |
| [emergence of resistance to antibiotics in enteropathogens. implications and speculations]. | 1985 | 3915679 | |
| emergence of sulfamethoxazole-trimethoprim resistant shigella flexneri in northeastern brazil. | in contrast to prior experience in this setting, three of four shigella flexneri strains recently isolated from patients in northeastern brazil with acute inflammatory diarrhea were found to be resistant to sulfamethoxazole, trimethoprim and the combination in vitro. we performed mating studies to determine if the resistance was transferable, and then isolated and characterized plasmid dna from the resistant shigella isolates, other resistant enterobacteriaceae isolated simultaneously from the s ... | 1985 | 3915680 |
| systemic mycosis in scottish red deer (cervus elaphus). | the pathological features of 10 cases of systemic infection of young red deer by fungi morphologically identified as phycomycetes are described. the most frequently affected organs were the kidneys, followed by liver and central nervous system. the fungi stimulated an acute pyogenic inflammatory reaction and a phagocytic giant cell response. vasculitis with thrombosis and spread of fungi to the surrounding tissue was a common finding. culture was attempted in 4 cases; one yielded absidia, 2 aspe ... | 1985 | 3915751 |
| [shigellemia in a patient with the septic variant of the course of dysentery (clinical case)]. | 1985 | 3916350 | |
| cell-mediated immunity in type i (insulin-dependent) diabetes of man and the bb rat. | 1985 | 3916413 | |
| [effect of sulfonamides on the fatty acid composition of enterobacterial lipids]. | 1985 | 3917183 | |
| inefficacy of penicillin v in acute laryngitis in adults. evaluation from results of double-blind study. | patients with acute laryngitis following an upper respiratory tract infection are often treated with antibiotics for their voice complaints, although, to our knowledge, the effect of such therapy has not been examined. in the present study, comprising 100 adults with laryngitis, the rate of resolution of vocal symptoms, as estimated from voice recordings or subjectively by the patients, was the same in patients who received penicillin v (pcv) as in those who received placebo. similarly, the degr ... | 1985 | 3918495 |
| in vivo efficacy and ultrastructural effects of mitomycin c against experimental alveolar hydatid disease. | the in vivo efficacy and ultrastructural effects of mitomycin c were determined against alveolar hydatid disease in experimentally infected animals and compared to mebendazole treatment. mitomycin c inhibited the mean cyst mass of treated versus control animals by 84.1% which was statistically significant at the alpha = 0.01 level. mebendazole given daily inhibited the mean cyst mass by 80.1%, while mebendazole administration on the same treatment schedule as that used for mitomycin c inhibited ... | 1985 | 3921601 |
| effect of human gamma interferon on invasiveness of salmonella typhimurium in hep-2 cell cultures. | the effect of human gamma interferon (huifn-gamma) on the invasiveness of salmonella typhimurium, shigella flexneri and yersinia enterocolitica serotype 0:3 in hep-2 cell cultures was examined. the intracellular and extracellular bacteria were identified by a combination of nomarski differential interference contrast microscopy and uv incident light microscopy applied on the same microscope. pretreatment of hep-2 cells with huifn-gamma reduced in a dose dependent manner the number of s. typhimur ... | 1985 | 3921632 |
| properties of human anti-lipopolysaccharide gamma globulin: specificity and protective effects. | blood donated to the natal blood transfusion service was screened by an enzyme-linked immunosorbent assay (elisa) for anti-lipopolysaccharide (anti-lps) antibodies. plasma units with high concentrations (greater than 40 micrograms/ml) of anti-lps igg were pooled and fractionated to obtain a gamma globulin (lot lg-1). the binding of lg-1 antibodies to lps prepared from 14 bacterial species and strains was found to be the highest to lps from shigella flexneri, salmonella abortus equi and salmonell ... | 1985 | 3922117 |
| isolation and characterization of a new endo-beta-galactosidase from diplococcus pneumoniae. | an endo-beta-galactosidase, which hydrolyzes the internal beta-galactosidic linkages of r----glcnac (or galnac) beta 1----3gal beta 1----4glcnac (or glc), was isolated from the culture supernatant of diplococcus pneumoniae. the enzyme, named endo-beta-galactosidase dii, hydrolyzed linear n-acetyllactosamine repeating structures in glycolipids and glycopeptides to release oligosaccharides. the specificity of endo-beta-galactosidase dii is the same as that of escherichia freundii endo-beta-galacto ... | 1985 | 3922410 |
| pressure- and temperature-dependent adhesion of pseudomonas aeruginosa to hep-2 cells. | pseudomonas aeruginosa bacteria adhere to human epitheloid (hep-2) cells in culture. under normal atmospheric conditions (1 ata), this adhesion increased significantly when the temperature rose from 22 to 37 degrees c. under hyperbaric atmosphere (= air, 7 ata) conditions, a similar, significant enhancement of bacterial adhesion to the cells was noted when the temperature rose. if the temperature was kept stable at 22 or 37 degrees c and the pressure was increased from 1 to 7 ata, a pressure-ind ... | 1985 | 3925713 |
| radioimmunoassay of thyroxine in saliva. | a simple radioimmunoassay (ria) for thyroxine (t4) in saliva has been described. fifty euthyroid control subjects, 14 euthyroid pregnant women, 23 thyreotoxic and 10 hypothyroid patients were examined. serum t3, t4, thyroxine binding globulin (tbg) and tsh were measured simultaneously. the mean level of t4 in saliva in controls was 1.10 +/- 0.07 nmol/l. there was a good correlation between the saliva and serum t4 concentrations (r = 0.74) and between saliva t4 values and the t4/tbg ratio (r = 0. ... | 1985 | 3926523 |
| fractionation of radioactivity in the milk of goats administered 14c-aflatoxin b1. | a detailed fractionation of radioactivity in the milk of goats administered 14c-aflatoxin b1 at low doses was performed. the milk collected in the first 24 h following dosing contained radioactivity equivalent to 0.45-1.1% of the dose given. the radioactivity in each sample was partitioned into 4 fractions: ether, protein, dichloromethane, and water-alcohol. over 80% of the radioactivity was detected in the dichloromethane fraction, of which over 95% was attributable to aflatoxin m1. no aflatoxi ... | 1985 | 3926742 |
| fractionation of radioactivity in the milk of goats administered 14c-aflatoxin b1. | a detailed fractionation of radioactivity in the milk of goats administered 14c-aflatoxin b1 at low doses was performed. the milk collected in the first 24 h following dosing contained radioactivity equivalent to 0.45-1.1% of the dose given. the radioactivity in each sample was partitioned into 4 fractions: ether, protein, dichloromethane, and water-alcohol. over 80% of the radioactivity was detected in the dichloromethane fraction, of which over 95% was attributable to aflatoxin m1. no aflatoxi ... | 1985 | 3926742 |
| improved control in advanced head and neck cancer with simultaneous radiation and cisplatin/5-fu chemotherapy. | chemotherapy with cisplatin plus 5-fu infusion was given simultaneously with radiation therapy; both were administered every other week. twenty-seven patients with stage iv disease and three with stage iii disease were treated; 57% had t4, 33% had n3, and 10% had m1 disease. of these patients, 17 (57%) achieved complete response and the rest achieved partial response. however, whether or not a clinically complete response occurred had no effect on subsequent risk for disease recurrence. with a m ... | 1985 | 3928158 |
| in vitro pyocin activity of pseudomonas aeruginosa strains pretreated with antibiotics. | fifty-six selected strains of pseudomonas aeruginosa belonging to 8 different pyocin types (h, i, 15, 6, pti-1, pti-2, pti-3, pti-4) were treated with subinhibitory concentrations (mic/2) of either gentamicin or carbenicillin. both treatments induced changes in pyocin patterns for all types but at different levels. the percentage of strains that retained their pyocin pattern were more or less equal in both treatments. in treated and untreated producers, the growth inhibition ability for 5 differ ... | 1985 | 3928466 |
| clues to the puzzle of purpose. | 1985 | 3929138 | |
| [study on an intestinal loop test of virulent shigella bacillus]. | 1985 | 3932548 | |
| selected overview of nongynecologic surgical intra-abdominal infections. prophylaxis and therapy. | true prophylaxis of intra-abdominal nongynecologic infections is limited to elective, nonemergency surgery and is best shown in three clean-contaminated surgical procedures. all of these have an infection rate of approximately 10 to 20 percent and include all colon resection surgery, most gastric surgery, and about one third of the cholecystectomies for chronic calculous cholecystitis. each of these three surgical procedures has a somewhat different pattern of bacterial pathogens. the most usefu ... | 1985 | 3934966 |
| [enhanced effectiveness of antibiotic therapy with an exogenous lysozyme in dysentery in children]. | the course of dysentery and the host immune responsiveness were studied in 171 children with acute flexner's and sonne dysentery. 67 children were treated with monomycin in combination with lysozyme and 104 children with monomycin alone. it was shown that the recovery period in children treated with monomycin and lysozyme was shorter as compared to that in children treated with monomycin alone. the immunity characteristics in children treated with monomycin were closer to the physiological value ... | 1985 | 3936408 |
| evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with trypanosoma cruzi strains of different types. | a test was made of the susceptibility of 30 strains of trypanosoma cruzi to chemotherapy with nifurtimox (bay 2502) and benznidazole (ro 7-1051). the strains had previously been classified as type i, ii, or iii according to their morphobiological and isoenzymic characteristics. three type i strains, 14 type ii strains, and 13 type iii strains were studied. mice were infected with 2 x 10(5) blood forms of these parasites and treated for 90 days with benznidazole or nifurtimox. all the surviving m ... | 1985 | 3936634 |
| chlamydial proctitis? | chlamydia trachomatis was isolated from 21 (7%) of 309 specimens obtained in october 1982 from the rectum of homosexual men undergoing proctoscopy. during the same period neisseria gonorrhoeae was isolated from 12 (3%) of 454 specimens obtained similarly. the clinical features of patients infected with each of these micro-organisms were compared with those of an uninfected group of homosexual men. no characteristic diagnostic features were noted in the infected men. | 1985 | 3936777 |
| arteriovenous flow reversal, experimental investigations. i. complete flow reversal of the small intestine and of the rear extremity of the dog. | segments of the small intestine and hind extremities of dogs were perfused under the condition of complete arterio-venous flow reversal (avfr). in the intestinal segments, the peripheral resistance under avfr conditions was 4.4 times higher than under orthograde perfusion. petechiae and hemorhagic infarction were observed. the average flow resistance of the hind extremities was 2.4 times higher than the resistance in control extremities. the po2 and the o2 saturation in the blood, outflowing fro ... | 1985 | 3937361 |
| assessment by a two-site enzyme immunoassay of human epidermal growth factor (urogastrone) in the urine of patients with various gastrointestinal diseases including malignant tumors. | by using our two-site enzyme immunoassay (eia) system, the levels of human epidermal growth factor (hegf) in the urine of patients with various gastrointestinal diseases including malignant tumors were measured. urinary excretion of hegf in patients having undergone gastric resection, expressed as a function of creatinine, was found to be somewhat decreased. while the levels of hegf in patients with gastric cancer were significantly increased. then, the molecular features of hegf in the urine of ... | 1985 | 3937528 |
| initiation and promotion in young and old animals. implications for human tumour formation. | the significance of ageing in experimental skin carcinogenesis and on the manifestation of tumour formation in man was studied. initiation with the carcinogenic hydrocarbon 7,12-dimethylbenz [a]anthracene and promotion with croton oil in mouse skin showed that tumour formation was unchanged when promotion was delayed 3, 10, 23 or 43 weeks in comparison with that in untreated animals of the same age. the sensitivity to carcinogen treatment of animals over 71 weeks of age was less than that of ani ... | 1985 | 3938448 |
| [virulence of shigella: epithelial cell invasiveness and other dysentery-producing factors]. | 1985 | 3938489 | |
| the distribution of acetylcholine and choline in guinea pig heart. | the regional distributions of acetylcholine (ach) and choline (ch) in the guinea pig heart were investigated with a pyrolysis-mass fragmentography technique. using ach as a marker for cholinergic neurons, we have described a pattern of parasympathetic innervation in the guinea pig heart. this distribution is very similar to that suggested by studies using several different cholinergic indicators in various species. atrial areas receive richer parasympathetic innervation than ventricular areas, w ... | 1985 | 3965854 |
| characterisation of a dictyostelium discoideum dna fragment coding for a putative trnavalguu gene. evidence for a single transcription unit consisting of two overlapping class iii genes. | a genomic dna fragment from dictyostelium discoideum was characterized. this dna, although 74% d(a + t)-rich, codes for a putative trnavalguu. the trnaval gene overlaps at its 5' half with another rna polymerase iii transcription unit. this rna polymerase iii transcription unit can be folded into a trna-like shape and is comprised of significant amounts of invariant and semi-invariant nucleotides present in all eukaryotic trnas. this unit contains the two promoter blocks defined for rna polymera ... | 1985 | 3967666 |
| development and morphology of rat synovial membrane. | the development of the knee joint and synovial membrane in wistar rats was studied from the 13th fetal day until adulthood by means of light microscopy, transmission electron microscopy and scanning electron microscopy. using acid phosphatase and peroxidase methods, the different cell types of synovial membrane could be identified. | 1985 | 3969821 |
| structural identification of platelet activating factor in psoriatic scale. | platelet activating factor was isolated from the lesional scale of psoriatic patients using the method described by bligh and dyer (8). the extract was subjected to thin layer chromatography, and the region of the plate co-migrating with platelet activating factor removed. a portion of each sample was assayed for aggregating activity using washed guinea-pig platelets and the remainder treated with phospholipase c, derivatised, and subjected to reversed phase high performance liquid chromatograph ... | 1985 | 3970690 |
| spatial contrast sensitivity deficits in monkeys produced by optically induced anisometropia. | an anisometropia was simulated in infant rhesus monkeys by securing a high-powered minus lens (-10 d) in front of one eye. the anisometropia rearing procedure was initiated at 30 days of age and was continued for durations of 30, 60, or 90 days. behavioral measurements of spatial contrast sensitivity obtained when the animals were 9 months of age indicated that the monkeys treated for 30 days had equal or nearly equal contrast sensitivities and cut-off spatial frequencies in the two eyes. the 30 ... | 1985 | 3972513 |
| synthesis of bunyavirus-specific proteins in a continuous cell line (xtc-2) derived from xenopus laevis. | the xtc-2 cell line, derived from xenopus laevis, supported the replication of representative viruses from each of the four genera in the family bunyaviridae. generally, viral titres were higher in xtc-2 cells than in other susceptible cell lines, and for some viruses plaques were detected earlier in xtc-2 cells. the xtc-2 cell line permitted comparative analyses of bunyavirus-specific protein synthesis. the patterns of synthesis of viral proteins, characteristic of each of the genera, were obse ... | 1985 | 3973561 |
| effects of neuronal activity on inositol phospholipid metabolism in the rat autonomic nervous system. | the effect of nerve stimulation on inositol phospholipid hydrolysis in autonomic tissue was assessed by direct measurement of [3h]inositol phosphate production in ganglia that had been preincubated with [3h]inositol. within minutes, stimulation of the preganglionic nerve increased the [3h]inositol phosphate content of the superior cervical sympathetic ganglion indicating increased hydrolysis of inositol phospholipids. this effect was blocked in a low ca2+, high mg2+ medium. it was also greatly r ... | 1985 | 3973589 |
| noninvasive measurement of pressure/volume characteristics in human limb veins by electrical admittance plethysmography. | 1985 | 3974317 | |
| [effects of porta-systemic shunts on the liver]. | 1985 | 3979196 | |
| chronic cutaneous granulomatous dermopathy: morphologic and serologic evaluation, differential diagnosis and pharmacologic control. | we report on a syndrome of disfiguring lower extremity cutaneous lesions of 6 years duration. previous medical evaluations included 5 skin biopsies and several therapeutic regimens which did not alter the course of illness. the histologic interpretations of skin biopsies included panniculitis, papulonecrosis, and granuloma. one biopsy was interpreted as a localized cutaneous vasculitis with a wedge-shaped infarct. infectious, collagen vascular, and factitious etiologies could not be demonstrated ... | 1985 | 3980110 |
| complement and hla. further definition of high-risk haplotypes in insulin-dependent diabetes. | the families of 41 probands with type i (insulin-dependent) diabetes mellitus (iddm) were typed for hla-a, hla-b, and hla-dr antigens in addition to the complement polymorphisms c2, c4a, c4b, and bf. all of these loci are encoded on the short arm of human chromosome 6 in a narrow region. alleles at hla-b (8, 15, 18, and 40), hla-dr (3 and 4), and bf (f1) have been associated with increased relative risk (rr) for iddm, while hla-b7 and hla-dr2 have been associated with decreased rr for iddm. this ... | 1985 | 3987976 |
| the effect of intermittent lighting on growth, feed:gain ratio, and abdominal fat content of broiler chickens of various genotypes and sex. | intermittent lighting (il) regimens were tested for rearing broiler chickens from 2 to 7 weeks of age. in experiments 1 and 2, the effects of 6 cycles of light (l) and darkness (d) of 1l:3d vs. 12 cycles of .25l:1.75 d were compared on the performance of 2400 broiler chickens. eight genotypes of 5170 mixed-sex broilers were used to compare effects of 6 cycles of 1l:3d vs. 1 cycle per day of 23.5l:.5d on broiler performance (experiment 3). the sexes responded differently to two il regimens in exp ... | 1985 | 3991421 |
| [persistent chlamydia infection in cell culture]. | 1985 | 3993192 | |
| plasma prolactin in the rat during suckling without prior separation from pups. | the relation between suckling and plasma prolactin (prl) was studied in the rat, without prior separation of the dam from its pups. when the pups were replaced by a hungry foster litter, upon renewed suckling plasma prl showed episodic increases and decreases in individual rats. when, subsequent to litter removal, similar rats were injected with perphenazine, a significant increase of plasma prl was observed. this indicates that a decline of plasma prl during suckling was not caused by exhaustio ... | 1985 | 3993313 |
| the corneal endothelial cell interface. | the apical edges of corneal endothelial cells have been separated along lines forming a crisscross pattern, by the help of a special method of preparation. the visualization by sem of the lateral faces of the cells is thereby made possible. the separation leads to the formation of thin strands spanning the gap between the apical edges of adjoining cells. they are formed by stretching of the normal apical flaps. this stretching demonstrates that the main intercellular adherence is located at the ... | 1985 | 3993338 |
| the acquired immunodeficiency syndrome (aids) in denmark. a report from the copenhagen study group of aids on the first 20 danish patients. | twenty danish patients with the acquired immunodeficiency syndrome (aids) had been diagnosed by january 1984, 14 of them after 1982. eighteen patients were male homosexuals, 8 of whom had visited the usa after 1979, 2 were heterosexual males with a history of sexual contacts in central africa, suggesting a transmission of aids from woman to man. aids has not been observed in drug abusers, hemophiliacs or transfused non-risk persons in denmark. the clinical picture varied according to the presenc ... | 1985 | 3993435 |
| longitudinal study of salt preferences in normotensive and hypertensive rats. | to determine whether age-related changes in salt preferences occur over the lifespans of spontaneously hypertensive rats (shr) and wistar-kyoto rats (wky), the same animals of each genotype were tested as juveniles, and as young and older adults. taste preference ratios for nacl and kcl, at concentrations from 0.001 to 1.0 m, were calculated using 24-hour, two-bottle preference tests of each salt versus distilled water. genotype exerted a significant effect on preference for both nacl and kcl (p ... | 1985 | 3997218 |
| longitudinal study of salt preferences in normotensive and hypertensive rats. | to determine whether age-related changes in salt preferences occur over the lifespans of spontaneously hypertensive rats (shr) and wistar-kyoto rats (wky), the same animals of each genotype were tested as juveniles, and as young and older adults. taste preference ratios for nacl and kcl, at concentrations from 0.001 to 1.0 m, were calculated using 24-hour, two-bottle preference tests of each salt versus distilled water. genotype exerted a significant effect on preference for both nacl and kcl (p ... | 1985 | 3997218 |
| cadmium chloride susceptibility, a characteristic of campylobacter spp. | we report a simple diagnostic characteristic useful in the presumptive identification of campylobacter jejuni and campylobacter coli. filter paper disks impregnated with cadmium chloride were placed on streaked agar medium. zones of growth inhibition for campylobacter spp. occurred at 1.25 micrograms per disk. other enteropathogens (salmonella spp., shigella spp., vibrio cholerae, vibrio parahaemolyticus, escherichia coli, and yersinia enterocolitica) were resistant to at least 40 micrograms per ... | 1985 | 3998099 |
| complement activation and clearance in acute illness and injury: evidence for c5a as a cell-directed mediator of the adult respiratory distress syndrome in man. | the appearance of the adult respiratory distress syndrome (ards) during the course of acute illness is believed to result, in part, from intrapulmonary neutrophil sequestration and degranulation induced by circulating inflammatory mediators. to evaluate the role of complement-neutrophil interactions in the pathogenesis of ards in man, 34 patients suffering from intra-abdominal sepsis (seven), multisystem trauma (15), or acute pancreatitis (12) were serially studied with regard to neutrophil migr ... | 1985 | 4002115 |
| hemodilution during standardized hemorrhage in high-altitude acclimatized rats. | ten control rats and sixteen high-altitude acclimatized rats were bled at sea level into a reservoir which maintained arterial pressure at 35 mm hg. as soon as the animals had spontaneously taken back 30% of the maximum bleeding volume, all the shed blood remaining in the reservoir was reinfused. hemodilution was studied during the first half phase of hypotension starting from the point of initial blood withdrawal and ending at the point of maximum blood loss. changes in hematocrit, hemoglobin c ... | 1985 | 4004677 |
| hemodilution during standardized hemorrhage in high-altitude acclimatized rats. | ten control rats and sixteen high-altitude acclimatized rats were bled at sea level into a reservoir which maintained arterial pressure at 35 mm hg. as soon as the animals had spontaneously taken back 30% of the maximum bleeding volume, all the shed blood remaining in the reservoir was reinfused. hemodilution was studied during the first half phase of hypotension starting from the point of initial blood withdrawal and ending at the point of maximum blood loss. changes in hematocrit, hemoglobin c ... | 1985 | 4004677 |
| 31p-saturation-transfer nuclear-magnetic-resonance measurements of phosphocreatine turnover in guinea-pig brain slices. | the technique of 31p saturation-transfer n.m.r. was used to determine the forward and the reverse rate constants of creatine phosphotransferase in superfused guinea-pig cerebral tissues in vitro. the calculated forward rate constant of 0.22 +/- 0.03s-1 compared well with a previously reported value for rat brain in vivo [shoubridge, briggs & radda (1982) febs lett. 140, 288-292]. the reverse rate constant was found to be 0.55 +/- 0.10s-1. 3. by using concentrations of atp and phosphocreatine est ... | 1985 | 4004799 |
| lack of effect of intranigral administration of a dopamine analogue, (+/-)-3-(3-hydroxyphenyl)-n,n-propylpiperidine [(+/-)-3-ppp], on nigrostriatal dopamine neurones. | bilateral injection of apomorphine into the zona reticulata of substantia nigra in rats reduced locomotor activity and striatal dopamine (da) turnover. in contrast, bilateral injection of (+/-)-3-(3-hydroxyphenyl)-n,n-propylpiperidine [(+/-)-3-ppp] into the zona reticulata (zr) did not reduce locomotor activity and did not affect striatal da turnover. a high dose of (+/-)-3-ppp increased locomotor activity. unilateral injection of (+/-)-3-ppp, but not of apomorphine, into the zr induced a brief ... | 1985 | 4011049 |
| [mechanism of the anti-arrhythmic action of phosphocreatine in acute myocardial ischemia]. | the association between phosphocreatine's antifibrillatory action and its effect on the excitement propagation processes in the ischemic area was investigated under acute coronary arterial occlusion in dogs. ischemia considerably reduced the amplitude, and increased the duration and time of onset, in local electrograms, and provoked cardiac fibrillation at the time of occlusion or during the recovery of coronary flow. a single intravenous injection of 300 mg/kg phosphocreatine eliminated cardiac ... | 1985 | 4021280 |
| isolation and sequence of cdna clones coding for a member of the family of high mobility group proteins (hmg-t) in trout and analysis of hmg-t-mrna's in trout tissues. | a specific oligonucleotide has been used to isolate a cdna prepared from the mrna for a trout high mobility group (hmg) protein closely related to trout hmg-t and bovine hmg 1 and 2 proteins. the sequence isolated more closely resembles bovine hmg-1 than the previously sequenced hmg-t protein in regions corresponding to the n terminal half of the protein. northern blot analysis at low stringency indicated that 2 related sequences are expressed in total trout testis mrna. southern blots of total ... | 1985 | 4022777 |
| tenckhoff catheter obstruction resulting from invasion by curvularia lunata in the absence of peritonitis. | a 60-year-old black woman on continuous ambulatory peritoneal dialysis (capd) presented with tenckhoff catheter malfunction. she exhibited no signs or symptoms of acute peritonitis. darkly pigmented plaques were adherent to the inner wall of the catheter and exchange tubing focally throughout its length. similar material was adherent to the protein coagulum in the dialysis bag. the tenckhoff catheter and tubing were removed, and hemodialysis was initiated. cultures of the catheter and the dialys ... | 1985 | 4025332 |
| identification of urinary metabolites of the nephrotoxic hydrocarbon 2,2,4-trimethylpentane in male rats. | the compound 2,2,4-trimethylpentane (2,2,4 tmp) is reported to be especially potent in inducing kidney lesions in male rats (1,2). although the pathology produced by 2,2,4 tmp has been examined (1), there are no reports concerning the metabolism of 2,2,4 tmp by the male rat. the eight principal urinary metabolites of 2,2,4 tmp found in the urine of fischer 344 male rats are: 2,2,4-trimethyl-1-pentanol, 2,4,4-trimethyl-1-pentanol, 2,4,4-trimethyl-2-pentanol, 2,2,4-trimethyl-1-pentanoic acid, 2,4, ... | 1985 | 4026835 |
| [characteristics of a cell line obtained from a human hypernephroma]. | a stable tumorigenic cell line has been obtained from the human hypernephrome. the culture grew as monolayers of large polygonal cells with foamy cytoplasm and 1-2 nucleoli. the cells formed monolayer after the third day after planting into flask and then formed multilayered growth. the electron microscopic studies of hypernephrome sections revealed the dark and light cells. the hypernephrome cells have characteristics of tumor cells. on the 200th passage the cells are aneuploid with a model num ... | 1985 | 4027291 |
| the effect of histone h1 on the compaction of oligonucleosomes. a quasielastic light scattering study. | the structural properties of h1-depleted oligonucleosomes are investigated by the use of quasielastic laser light scattering, thermal denaturation and circular dichroism and compared to those of h1-containing oligomers. to obtain information on the role of histone h1 in compaction of nucleosomes, translational diffusion coefficients (d) are determined for mono-to octanucleosomes over a range of ionic strength. the linear dependences of d on the number of nucleosomes show that the conformation of ... | 1985 | 4027333 |
| outbreak of shigella flexneri 1 infection in british columbia. | 1985 | 4027813 | |
| myocardial recovery after hypothermic arrest: a comparison of oxygenated crystalloid to blood cardioplegia. the role of calcium. | we compared multidose crystalloid hyperkalemic cardioplegic solutions with and without added red cells in 24 canine hearts subjected to 5 hr of arrest at 10 degrees c. all cardioplegic solutions were fully oxygenated at 4 degrees c before delivery. since blood cardioplegia contained ca++ carried over with the red cells, ca++ was added to the crystalloid solution in one group. the table below shows the hematocrit (hct) and ionized ca++ concentrations of the cardioplegic solutions, and coronary ar ... | 1985 | 4028363 |
| myocardial recovery after hypothermic arrest: a comparison of oxygenated crystalloid to blood cardioplegia. the role of calcium. | we compared multidose crystalloid hyperkalemic cardioplegic solutions with and without added red cells in 24 canine hearts subjected to 5 hr of arrest at 10 degrees c. all cardioplegic solutions were fully oxygenated at 4 degrees c before delivery. since blood cardioplegia contained ca++ carried over with the red cells, ca++ was added to the crystalloid solution in one group. the table below shows the hematocrit (hct) and ionized ca++ concentrations of the cardioplegic solutions, and coronary ar ... | 1985 | 4028363 |
| stable oil-in-water emulsions: preparation and use as vaccine vehicles for lipophilic adjuvants. | many of the most potent immunoadjuvants for inclusion in vaccines are extremely hydrophobic surfactants. lipophilic vehicles are needed as carriers for these water-insoluble adjuvants and to provide the hydrophilic-hydrophobic interfacial surface at which they act. we used emulsifiers comprised of fatty acid esters of polyoxyethylene sorbitan (tweens) or sorbitan (spans) to prepare oil-in-water (o/w) emulsions of hexadecane. emulsion stability could be predicted from a ratio of spectrophotometri ... | 1985 | 4036272 |
| role of uricase in the triggering of germination of bacillus fastidiosus spores. | the likelihood that uric acid was the only compound capable of triggering germination of bacillus fastidiosus spores was reinforced by the finding that ureidoglycollic acid, urea, nh4cl, 2,8-dihydroxypurine and a combination of l-alanine and o-carbamoyl-d-serine were ineffective as germinants. uric acid-triggered germination of b. fastidiosus was prevented by a range of inhibitors that also inhibited uricase activity in dormant spore extracts. o2 uptake during germination started immediately aft ... | 1985 | 4038258 |