Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| direct retinal pathways to the limbic thalamus of the monkey. | tritiated proline, horseradish peroxidase (hrp), and wheat germ agglutinin conjugated to hrp (wga-hrp) were used as anterograde tracers in the monkey to reveal visual pathways. after intravitreal injections, three separate, direct routes of labeled retinal axons were followed to the thalamus. these routes eventually converged to innervate the lateral dorsal and anterodorsal thalamic nuclei. thus, retinal input may reach the posterior cingulate cortex after a single synapse in lateral and anterio ... | 1986 | 3754221 |
| [3h]pirenzepine and (-)-[3h]quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites. i. characterization and regulation of agonist binding to putative muscarinic subtypes. | the binding and regulation of selected muscarinic agonists to putative subtypes in rat cerebral cortex and heart were studied. parallel inhibition studies of [3h]pirenzepine ([3h]pz) and (-)-[3h]quinuclidinylbenzilate [(-)-[3h]qnb]-labeled membranes were done with and without 30 microm guanyl-5'-yl imidodiphosphate [gpp(nh)p] at 25 degrees c in 10 mm na-k-phosphate buffer which enhances pz binding affinity and in modified krebs-phosphate buffer, which mimics physiological conditions. classical a ... | 1986 | 3754580 |
| ketoconazole-induced reduction in serum 1,25-dihydroxyvitamin d. | the antimycotic agent ketoconazole is known to inhibit several cytochrome p450-dependent enzymes involved in the biosynthesis of steroid hormones from cholesterol. since 1,25-dihydroxyvitamin d is also a sterol synthesized by cytochrome p450-dependent enzymes, we assessed whether ketoconazole would lower serum 1,25-dihydroxyvitamin d levels. in nine normal men, administration of ketoconazole for 1 week in doses of 300-1200 mg/day led to a dose-dependent reduction in serum 1,25-dihydroxyvitamin d ... | 1986 | 3755445 |
| how a child's blood pressure is related to psychological influences. some results with r. zazzo's bestiary test. | the purpose of the study was to investigate the relationships between some psychological characteristics and blood pressure. we used the bestiary test which gives an impression of the child's psychological characteristics and his way of coping with personal conflicts. the test was applied to 766 children between the ages of 4-10 years. by discriminant analysis we established relations between systolic blood pressure, and the responses to the test. by correspondence analysis we found that hyperte ... | 1986 | 3757284 |
| uptake of 450191-s, a 1h-1,2,4-triazolyl benzophenone derivative, in the everted sac of rat small intestine: role of intestinal aminopeptidases. | 5-[(2-aminoacetamido)methyl]-1-[p-chloro-2-(o-chlorobenzoyl)phenyl ]-n,n-dimethyl-1 h-1,2,4-triazole-3-carboxamide hydrochloride dihydrate (450191-s), a sleep inducer, is a ring-opened derivative of 1,4-benzodiazepine and has been reported to be activated by intestinal aminopeptidases in a step of absorption. in this study, we investigated the role of the intestinal aminopeptidases in the uptake of 450191-s by the intestine by using various aminopeptidase inhibitors in everted sacs of rat small ... | 1986 | 3761138 |
| myocardial ischemia stimulates catecholamine synthesis and catabolism in the dog adrenal medulla. | the effects of regional ischemia of the myocardium upon metabolism and catabolism of catecholamines were studied in the dog adrenal medulla. regional ischemia was induced by ligating a small branch of the left anterior descending coronary artery for 1 or 24 hours. sham-operated controls were run in parallel. coronary ligation for 24 hours resulted in a decrease in the level of epinephrine and an increase in the level of dopamine in the adrenal medulla, and also resulted in an increase in the act ... | 1986 | 3761566 |
| the complex nature of food antigens: studies of cross-reacting crustacea allergens. | 1986 | 3767090 | |
| [establishment of a spontaneously transformed human fetal lung cell line and its biological characteristics]. | a spontaneously transformed human fetal lung cell line (hflt) was derived from a human fetal lung diploid fibroblast cell line (2bs) by continuous culture. the biological characteristics of this cell line were studied and compared with those of 2bs cells. accompanying the morphological alteration, the growth rate of the transformed cell was accelerated and the maximum cell density was increased. the anchorage-independent growth was shown by its ability to form colonies in soft agar. the collagen ... | 1986 | 3769747 |
| widowhood, sex, labor force participation, and the use of physician services by elderly adults. | this paper investigated the relationships of widowhood, sex, and labor force participation with the use of ambulatory physician services by elderly adults. data on 18,441 individuals aged 55 and over were taken from the 1978 health interview survey. hierarchical regression results indicated that although these three factors are related to physician utilization at the zero- and first-partial levels, only sex remained significant when their two- and three-way interactions and other variables from ... | 1986 | 3772057 |
| a human y-chromosome specific repeated dna family (dyz1) consists of a tandem array of pentanucleotides. | we have determined the complete nucleotide sequence of a 3564 bp ecori fragment which represents a major component of the human y-chromosome specific repeated dna family (dyz1). sequencing result showed a tandem array of pentanucleotides after five nucleotides were inserted or deleted at four positions. 229 out of the 713 pentanucleotides were ttcca, and 297 were its single-base substituents. southern hybridization analyses of male genomic dnas showed that several endonuclease cleavage sites wer ... | 1986 | 3774538 |
| effects of sex steroids on the development of two granule cell subpopulations in the rat accessory olfactory bulb. | the effects of postnatal male castration on day 1 (d1) after birth and female androgenization on accessory olfactory bulb (aob) light and dark granule cell populations were studied. control males showed a greater number of both light and dark aob granule cells than females. postnatal treatment reversed these differences in the light granule cells. female androgenization on d1 does not affect the number of aob dark granule cells. however, male orchidectomy also on d1 significantly decreases the n ... | 1986 | 3779445 |
| gangliosides and synaptosomal calcium homeostasis. | in this study, depolarization-dependent (net) calcium transport and binding capacity to rat brain synaptosomes was investigated under conditions affecting the ganglioside composition of the synaptoplasmatic membranes. specific interaction of the monosialoganglioside gm1 with the membrane, as observed in low (40 nm) concentration of ganglioside, resulted in significant inhibition of the maximal depolarization-induced calcium uptake. the changes in ganglioside composition of synaptosomes produced ... | 1986 | 3781769 |
| the mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. | we describe the structure of a novel and unusually heterologous beta-tubulin isotype (m beta 1) isolated from a mouse bone marrow cdna library, and a second isotype (m beta 3) isolated from a mouse testis cdna library. comparison of m beta 1 and m beta 3 with the completed (m beta 4, m beta 5) or extended (m beta 2) sequence of three previously described beta-tubulin isotypes shows that each includes a distinctive carboxy-terminal region, in addition to multiple amino acid substitutions througho ... | 1986 | 3782288 |
| the mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. | we describe the structure of a novel and unusually heterologous beta-tubulin isotype (m beta 1) isolated from a mouse bone marrow cdna library, and a second isotype (m beta 3) isolated from a mouse testis cdna library. comparison of m beta 1 and m beta 3 with the completed (m beta 4, m beta 5) or extended (m beta 2) sequence of three previously described beta-tubulin isotypes shows that each includes a distinctive carboxy-terminal region, in addition to multiple amino acid substitutions througho ... | 1986 | 3782288 |
| [the effect of the alkaloid narcotine and its diols on tissue histamine levels]. | 1986 | 3786390 | |
| estimation of regional gas and tissue volumes of the lung in supine man using computed tomography. | this study was intended to discover how well computed tomography could recover the volume and weight of lung like foams in a body like shell, and then how well it could recover the volume and weight of the lungs in supine man. model thoraces were made with various loaves of bread submerged in water. computed tomography scans recovered the volume of the model lungs (true volume range 250-12,500 ml) within +0.2 (sd 68) ml and their weights (true range 72-3125 g) within +30 (78) g. scans also recov ... | 1986 | 3787544 |
| methylhistidine changes in tibialis anterior muscles of 6-mercaptopurine-treated rats. | 1986 | 3787652 | |
| failure of norfloxacin to eradicate chlamydia trachomatis in nongonococcal urethritis. | norfloxacin has some activity in vitro against chlamydia trachomatis and ureaplasma urealyticum, although not at levels attainable in serum. in this study, norfloxacin was administered (400 mg orally twice daily for 10 days) to men with acute nongonococcal urethritis. of 25 men from whom c. trachomatis was initially isolated, 21 had the organism reisolated at the first follow-up visit posttreatment, and there were minimal changes in the number of inclusion-forming units in culture. ultimately, a ... | 1986 | 3789692 |
| frequency of four classes of tetracycline resistance determinants in salmonella and shigella spp. clinical isolates. | the frequencies of tetracycline resistance determinants of the classes a, b, c, and d were determined in 53 non-lactose-fermenting clinical isolates. the most frequent class of determinant in salmonella typhimurium and shigella flexneri strains was class b; however, the predominant determinant in shigella sonnei strains was class c. | 1986 | 3789700 |
| glucose regulation of cephamycin biosynthesis in streptomyces lactamdurans is exerted on the formation of alpha-aminoadipyl-cysteinyl-valine and deacetoxycephalosporin c synthase. | glucose exerted a concentration-dependent negative regulation on the biosynthesis of cephamycin c by streptomyces lactamdurans. formation of the cephamycin precursor delta(alpha-aminoadipyl)-cysteinyl-valine was greatly decreased by excess glucose. the ring-expanding enzyme deacetoxycephalosporin c synthase was strongly repressed by glucose in vivo. isopenicillin n synthase (cyclase) and isopenicillin n epimerase were not repressed by glucose. however, the activity of isopenicillin n synthase wa ... | 1986 | 3794640 |
| suppression of free fatty acids and triglycerides in normal and hypertriglyceridemic rats by the adenosine receptor agonist phenylisopropyladenosine. | activation of adenosine receptors leads to the inhibition of lipolysis in the fat cells of several species including humans. we have examined the effects of the adenosine analog phenylisopropyladenosine (pia) on lipolysis in vivo in intact rats. pia suppresses markedly serum-free fatty acid (ffa) concentrations when injected s.c. (-)-pia is more potent than (+)-pia in suppressing ffa concentrations; also, this effect of (-)-pia is blocked by the adenosine receptor antagonist 8-(p-sulfophenyl)the ... | 1986 | 3795036 |
| inhibition of the platelet activating factor (paf)-induced in vivo responses in rats by trans-2,5-(3,4,5-trimethoxyphenyl) tetrahydrofuran (l-652,731), a paf receptor antagonist. | trans-2,5-bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran (l652, 731), a potent and specific receptor antagonist of platelet activating factor (paf) (hwang et al., j. biol. chem. 260: 15639-15645, 1985), potently inhibits several paf-induced in vivo responses in rats. intravenously and p.o. administered l-652,731 gave a dose-response inhibition of paf-induced lysosomal hydrolase secretion and extravasation with ed50 values of 1 and 3 mg/kg, respectively. inhibitions of 87% were achieved with 50 mg/k ... | 1986 | 3795043 |
| [role of the diabetogenic factor in the activation of the blood coagulation system in experimental alloxan diabetes]. | 1986 | 3797076 | |
| response of dogs to challenge with ancylostoma ceylanicum during the tenure of a primary hookworm infection. | a model of human hookworm infection has been developed which shows that dogs currently infected with small numbers of hookworms are considerably resistant to a challenge infection with a large inoculum of infective larvae. two groups of dogs were infected with 500 larvae and four weeks after infection one group together with a previously uninfected control group were infected with 5,000 larvae and followed for six weeks. when compared with the secondary infection control dogs, faecal egg excreti ... | 1986 | 3798534 |
| rabbit endocervical epithelium: morphometric analysis of secretory cell populations. | in this report we quantitated ultrastructural changes in two cytologically distinct secretory cell populations from the rabbit endocervix. type i and type ii cells from estrous animals differ only in the presence of one or more empty cytoplasmic vacuoles in type ii cells. comparing type ii cells from 5-day pseudopregnant (psp) rabbits with type ii cells from estrous controls, there is no increase (p greater than .05) in the average vacuole volume. when type i and type ii cells from psp animals a ... | 1986 | 3799998 |
| [changes in the characteristics of glucocorticoid hormone binding in human peripheral blood lymphocytes during myocardial infarct]. | competitive binding was used to determine the number of binding sites to glucocorticoid hormones in peripheral blood leukocytes of normal subjects, patients with unstable angina pectoris and patients with myocardial infarction. a sharp (2-3-fold) increase in the number of binding sites was observed in patients with myocardial infarction during the first 24 hours after the onset of the disease. | 1986 | 3801148 |
| a contribution to indirect ophthalmotonometry in beagles. | a test of suitability of the electroimpression tonometer from fritz schwarzer gmbh, munich, for measuring intraocular pressure in dogs was performed. intraocular pressure of 63 clinically healthy english beagles was measured in both eyes using the instrument with different plunger weights. intraocular pressure and volume of corneal depression during measurement were determined as a function of the plunger weight from readings on the tonometer with the aid of friedenwald's tables (2). using fried ... | 1986 | 3807468 |
| inferior olive lesion induces long-term modifications of cerebellar inhibition on deiters nuclei. | the frequency of discharge of cerebellar purkinje cells and lateral vestibular nuclear cells were recorded at different intervals of time after injection of 3-acetylpyridine (3ap), which destroys the inferior olivary nucleus. during the first few days, purkinje cells showed an increase of simple spike firing, while deiters cells showed a strong depression of their discharge. recordings up to 3 months demonstrated, for both groups of cells, a recovery, whose time course is faster for deiters cell ... | 1986 | 3808481 |
| inferior olive lesion induces long-term modifications of cerebellar inhibition on deiters nuclei. | the frequency of discharge of cerebellar purkinje cells and lateral vestibular nuclear cells were recorded at different intervals of time after injection of 3-acetylpyridine (3ap), which destroys the inferior olivary nucleus. during the first few days, purkinje cells showed an increase of simple spike firing, while deiters cells showed a strong depression of their discharge. recordings up to 3 months demonstrated, for both groups of cells, a recovery, whose time course is faster for deiters cell ... | 1986 | 3808481 |
| the hypoxic ventilatory response of rats with increased blood oxygen affinity. | experimental work has established an interspecific relationship between the threshold for the hypoxic ventilatory response and the 'knee' of the hb-o2 dissociation curve. however, whether this relationship exists intraspecifically remains unclear. to examine the problem further rats were treated with sodium cyanate (naocn) to lower p50 and their hypoxic ventilatory response was measured. naocn treated rats had a lower pao2 and higher hct than control rats. there was no difference between the con ... | 1986 | 3809758 |
| the hypoxic ventilatory response of rats with increased blood oxygen affinity. | experimental work has established an interspecific relationship between the threshold for the hypoxic ventilatory response and the 'knee' of the hb-o2 dissociation curve. however, whether this relationship exists intraspecifically remains unclear. to examine the problem further rats were treated with sodium cyanate (naocn) to lower p50 and their hypoxic ventilatory response was measured. naocn treated rats had a lower pao2 and higher hct than control rats. there was no difference between the con ... | 1986 | 3809758 |
| differences in adhesiveness among type 1 fimbriate strains of enterobacteriaceae revealed by an in vitro hep2 cell adhesion model. | ten type 1 fimbriate strains of enterobacteriaceae were examined in an in vitro adhesion assay with hep2 epithelial cells. the range of hep2 cell adhesiveness, which was characteristic for each strain, was affected by motility, type 1 fimbriation and production of mannose sensitive haemagglutinin. nevertheless, not all type 1 fimbriate strains adhered well in this model. the findings are discussed with regard to the possibility that different type 1 fimbriate enterobacteria, though all are manno ... | 1986 | 2881915 |
| anti-surface antibodies to entamoeba histolytica and their role in complement lysis. | 1986 | 2884957 | |
| glial differentiation in dissociated cell cultures of neonatal rat brain: noncoordinate and density-dependent regulation of oligodendroglial enzymes. | the mixed glial system of primary cultures of cells dissociated from neonatal rat brain was utilized to study glial differentiation. the investigation was addressed specifically to the possibility of noncoordinate regulation of two manifestations of oligodendroglial differentiation, i.e., activities of glycerol-3-phosphate dehydrogenase (gpdh) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (cnp), as well as the effects of initial cell density on the time of onset and the intensity of express ... | 1986 | 2870195 |
| transglutaminase and neuronal differentiation. | during mouse brain maturation cellular transglutaminase specific activity increases 2.5 fold from day 3 to adulthood. a more pronounced increase is seen during morphological differentiation of mouse neuroblastoma cells, where serum withdrawal induces neurite outgrowth concomitant with a 10 fold increase in transglutaminase specific activity. in contrast, non-dividing neuroblastoma cells lacking neurites show only a 1.5 fold increase in enzyme specific activity. transglutaminase activity does not ... | 1986 | 2870428 |
| transglutaminase and neuronal differentiation. | during mouse brain maturation cellular transglutaminase specific activity increases 2.5 fold from day 3 to adulthood. a more pronounced increase is seen during morphological differentiation of mouse neuroblastoma cells, where serum withdrawal induces neurite outgrowth concomitant with a 10 fold increase in transglutaminase specific activity. in contrast, non-dividing neuroblastoma cells lacking neurites show only a 1.5 fold increase in enzyme specific activity. transglutaminase activity does not ... | 1986 | 2870428 |
| integrating treatments in schizophrenia. | schizophrenia is a common and severe illness found throughout the world. onset is usually in adolescence and young adulthood, and many individuals have illness-related impairments for life. schizophrenia assaults the very essence of what is distinctly human. the personality is devastated, subjective experience and thought distorted, and the psychological building blocks of everyday life torn asunder. this article discusses diagnostic and conceptual considerations, pharmacotherapy, and interperso ... | 1986 | 2870478 |
| influence of dietary lipids on the effect of chlorpromazine on membrane properties of rabbit red cells. | the effect of diets containing different types of common natural oils on physical properties of red cells was investigated by using rabbits. the rabbits were fed for 18 months on a standard diet in which 8% of its energy content was provided by safflower oil and 32% energy by either more safflower oil or fish oil, linseed oil, olive oil or palm oil. erythrocyte deformability was significantly decreased by the fish oil diet compared with each of the other diets. osmotic fragility was significantl ... | 1986 | 2870499 |
| platelet aggregation caused by carybdea rastonii toxins (crtx-i, ii and iii) obtained from a jellyfish, carybdea rastonii. | the pharmacological mechanisms of platelet aggregation induced by highly toxic proteins (crtx-i, crtx-ii, and crtx-iii) obtained from tentacles of a jellyfish, carybdea rastonii, were investigated. when the partially purified toxin (pcrtx) and crtxs were added to the citrated platelet-rich plasma (prp), aggregation was produced in a concentration-dependent manner. the activity of crtxs was approximately 100 times more potent than pcrtx. the crtxs-induced aggregation was little affected by indome ... | 1986 | 2870502 |
| blood-finding strategy of a capillary-feeding sandfly, lutzomyia longipalpis. | salivary gland homogenates of adult female lutzomyia longipalpis inhibited platelet aggregation induced by adp and collagen. apyrase (atp diphosphohydrolase) activity was prominent, requiring ca2+ but not mg2+ and a ph optimum of 8.0. human as well as rabbit hosts developed a well delimited erythema, evident 2-3 min after initial probing and lasting for as long as 2 days. erythema, not accompanied by itching or swelling, developed in previously exposed hosts as well as in those not previously ex ... | 1986 | 2870860 |
| blood-finding strategy of a capillary-feeding sandfly, lutzomyia longipalpis. | salivary gland homogenates of adult female lutzomyia longipalpis inhibited platelet aggregation induced by adp and collagen. apyrase (atp diphosphohydrolase) activity was prominent, requiring ca2+ but not mg2+ and a ph optimum of 8.0. human as well as rabbit hosts developed a well delimited erythema, evident 2-3 min after initial probing and lasting for as long as 2 days. erythema, not accompanied by itching or swelling, developed in previously exposed hosts as well as in those not previously ex ... | 1986 | 2870860 |
| pharmacokinetics of t-2 toxin and its metabolite ht-2 toxin, after intravenous administration in dogs. | the pharmacokinetics of t-2 toxin and ht-2 toxin were investigated comparatively in five dogs, after iv administration of the toxins (0.4 mg/kg). t-2 toxin was very rapidly and almost completely biotransformed to ht-2 toxin (fm = 83.6 +/- 3.9%). the following mean pharmacokinetic parameters were determined in this study for t-2 toxin and ht-2 toxin, respectively: half-life 5.3 +/- 2.1 and 19.6 +/- 4.7 min, clearance 0.107 +/- 0.056 and 0.167 +/- 0.074 liters/min/kg, and volume of distribution 0. ... | 1986 | 2870902 |
| pharmacokinetics of t-2 toxin and its metabolite ht-2 toxin, after intravenous administration in dogs. | the pharmacokinetics of t-2 toxin and ht-2 toxin were investigated comparatively in five dogs, after iv administration of the toxins (0.4 mg/kg). t-2 toxin was very rapidly and almost completely biotransformed to ht-2 toxin (fm = 83.6 +/- 3.9%). the following mean pharmacokinetic parameters were determined in this study for t-2 toxin and ht-2 toxin, respectively: half-life 5.3 +/- 2.1 and 19.6 +/- 4.7 min, clearance 0.107 +/- 0.056 and 0.167 +/- 0.074 liters/min/kg, and volume of distribution 0. ... | 1986 | 2870902 |
| two bradykinin binding sites with picomolar affinities. | bradykinin (bk) and related peptides exert a wide range of effects on several organ systems. we have attempted to sort out these effects by studying the binding interaction of [3h]bk at the membrane level with in vitro receptor binding techniques. high specific activity [3h]bk and an enzyme inhibitor "cocktail" has enabled us to label two bk binding sites with different affinity and peptide specificity in several guinea-pig tissues. in the guinea-pig ileum the high-affinity site has an equilibri ... | 1986 | 2871174 |
| potent antagonism of escherichia coli, bacteroides ovatus, fusobacterium varium, and enterococcus faecalis, alone or in combination, for enteropathogens in anaerobic continuous flow cultures. | interactions between representative strains of four predominant resident bacteria of the human colon, escherichia coli, enterococcus faecalis, bacteroides ovatus, and fusobacterium varium, and strains of seven enteropathogens, yersinia enterocolitica, shigella flexneri, salmonella typhimurium, vibrio parahaemolyticus, v. cholerae serogroup non o1, staphylococcus aureus, and clostridium perfringens, were examined in studies with an anaerobic continuous flow culture system and medium resembling th ... | 1986 | 2875188 |
| the neurobiologic consequences of down syndrome. | trisomy of the whole or distal part of human chromosome 21 (hsa 21) (ts21) results in down syndrome (ds), which is characterized in part by mental retardation and associated neurological abnormalities. structural abnormalities observed frequently include reduced brain weight, decreased number and depth of sulci in the cerebral cortices, neuronal heterotopias, and reduced numbers of specific populations of neurons, such as granule cells, in the cerebral cortices. abnormalities in the structure of ... | 1986 | 2875770 |
| the fine structure of atypical ciliated cells in the human gastric epithelium. | gastric mucosa obtained from the body and pyloric portions of the human stomach were observed by light and transmission electron microscopy. ciliated cells were found in two of 18 subjects examined, one patient with gastric ulcer and the other one with gastric adenocarcinoma. the ciliated cells were found in epithelia at sites away from the main lesions. the tissues containing ciliated cells showed intestinal metaplasia combined with mild chronic gastritis in both cases. the epithelial layer fac ... | 1986 | 2876543 |
| evidence for a migratory capability of rat kupffer cells to portal tracts and hepatic lymph nodes. | the present study concerns the migratory ability of kupffer cells in the rat. phagocytic cells were labeled with colloidal carbon or gold, these markers being administered intravenously either into a tail vein, which resulted in generalized reticuloendothelial uptake, or in low dose into the portal vein, which produced uptake by kupffer cells alone. cells containing marker were observed in the portal tracts and in hepatic lymph nodes from 1 to 3 days after injection into the portal vein. the dir ... | 1986 | 2876547 |
| 6,7-dichloro-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline . a structurally novel beta-adrenergic receptor blocking agent. | replacement of the catecholic hydroxyl groups of the beta-adrenergic receptor agonist 6,7-dihydroxy-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (trimetoquinol) with chloro substituents results in a compound with marked beta-adrenoceptor antagonist properties. this, therefore, parallels the similar transformation of the beta-adrenoreceptor agonist isoproterenol into the antagonist dichloroisoproterenol. in a test for inhibition of isoproterenol-induced enhancement of the rate of con ... | 1986 | 2878080 |
| phenotypic modification of human glioma and non-small cell lung carcinoma by glucocorticoids and other agents. | glucocorticoids are cytostatic for human glioma grown at a high cell density in cell culture. the effect is not cytotoxic, appears to involve a modification of the cell surface, and has been detected with methyl prednisolone, dexamethasone, and beta-methasone. glucocorticoids were also found to reduce malignancy-associated properties (plasminogen activator and endothelial mitogenesis) and enhance differentiation (glutamyl synthetase activity and high affinity gaba uptake). cytostasis was also se ... | 1986 | 2879508 |
| genetic analysis of the plasmid region controlling virulence in yersinia enterocolitica 0:9 by mini-mu insertions and lac gene fusions. | enteropathogenic strains of yersinia enterocolitica harbor a virulence plasmid (pyve plasmid) of 70 kilobases (kb) which specifies, at 37 degrees c, a calcium requirement for growth, autoagglutinability, resistance to the bactericidal activity of human serum, and the expression of outer membrane proteins (omp). some mutations suppress the calcium requirement for growth while others make the bacteria unable to grow at 37 degrees c, even in the presence of calcium. to analyse the genes involved in ... | 1986 | 2854600 |
| anti-hla-b27 antibodies in sera from patients with gram-negative bacterial infections. | several forms of seronegative polyarthritis are strongly associated with hla-b27, and a number of microorganisms have been implicated in the etiology of these diseases. to explain the association between hla-b27 and arthritis initiated by infection with these organisms, it has been proposed that there is immunologic cross-reactivity between the b27 molecule and 1 or more microbial antigens, and that this cross-reactivity leads to tolerance to such infection and/or to the production of anti-hla-b ... | 1986 | 2421739 |
| [effect of levamisole immunocorrective therapy on the dynamics of infectious o-antigenemia and the clinical manifestations in dysentery patients]. | the immunocorrecting agent levamisole decreases the duration of infectious o-antigenemia, determined in the o-aggregate hemagglutination test and in the enzyme immunoassay, essentially accelerates the progress of convalescence and considerably decreases the possibility of the prolonged relapsing course of the disease in comparison with common methods of treatment. | 1986 | 2422855 |
| the response of the lung to foreign compounds that produce free radicals. | 1986 | 2423026 | |
| the interaction of myelin basic protein with tubulin and the inhibition of tubulin carboxypeptidase activity. | tubulin carboxypeptidase was found to be inhibited by myelin basic protein in a concentration dependent manner. the inhibition was produced by the interaction between myelin basic protein with the substrate. as a consequence of this interaction, turbid insoluble aggregates were formed at either 5 degrees or 37 degrees c. the turbidity increased by increasing the myelin basic protein concentration and it reached a plateau at a molar ratio of myelin basic protein to tubulin dimer of about 6. at pl ... | 1986 | 2423083 |
| mechanism of rna redistribution of the 17,000g postmitochondrial supernatant after incubation at 37 degrees c and its impact on other related biochemical investigations. | evidence for stripping of ribosomes from rer in the 17,000g pms of the liver of the cancer patient was obtained in the 1.35 m region which is the region between the ser and rer. rna/protein ratios for the ser, 1.35 m region, and rer of 0.001, 0.083, and 0.235, respectively, for this liver are consistent with the degranulation of rer compared with rna/protein ratios for ser and rer from normal livers of 0.025 +/- 0.003, and 0.35 + 0.030, respectively. a rna/protein ratio of 0.235 was obtained for ... | 1986 | 2423101 |
| monoclonal antibodies specific for shigella flexneri lipopolysaccharides: clones binding to type i and type iii:6,7,8 antigens, group 6 antigen, and a core epitope. | monoclonal antibodies against the shigella flexneri lipopolysaccharide (lps) were generated in two fusions by using the myeloma cell line sp2/0 as a fusion partner with spleen cells from balb/c mice immunized with s. flexneri serotypes 1b and 3a bacteria. the antibodies were characterized by immunoblotting, enzyme-linked immunosorbent assay (elisa), hemagglutination, and coagglutination. four different types of monoclonal antibodies were isolated: antibodies specific for the core antigen of the ... | 1986 | 2424839 |
| shigella flexneri o-antigen epitopes: chemical and immunochemical analyses reveal that epitopes of type iii and group 6 antigens are identical. | in the present investigation we studied the nature of a shigella flexneri o antigen, the type iii antigen. no structural entity has yet been attributed to this antigen. phenol-water-extracted lipopolysaccharides (lpss) from all s. flexneri serotypes possessing either group 6 antigen or both type iii antigen and group 6 antigen were subjected to de-o-acetylation by weak alkali treatment. two-dimensional nuclear magnetic resonance spectra of serotype 3a native lps and de-o-acetylated lps were comp ... | 1986 | 2424840 |
| [nbt-test stimulation of neutrophilic granulocytes by bacterial preparations in healthy persons]. | 1986 | 2425131 | |
| changes in tonicity of perfusion medium cause prolonged opening of calcium channels of the rat chromaffin cells to evoke explosive secretion of catecholamines. | secretion of catecholamines (ca) from the isolated rat adrenal gland during and after perfusion with hypertonic krebs bicarbonate solution was studied. perfusion with hypertonic solution made by adding either 156 mm sodium chloride, choline chloride, arginine hydrochloride, sodium thiocyanate, or 312 mm sucrose had no effect on the spontaneous secretion of ca. the secretion evoked by splanchnic nerve stimulation (10 hz for 30 sec) and nicotine (2 micrograms) remained unaffected during perfusion ... | 1986 | 2427669 |
| human p85 glycoprotein bears three distinct epitopes defined by several monoclonal antibodies. | a glycoprotein of apparent mol. wt 85,000 isolated from human cells of b lineage by affinity to 50b4-igg immunoadsorbent was shown previously to express two spatially distinct epitopes identified with monoclonal antibodies 50b4 and 50e6 [letarte et al. (1985) molec. immun. 22, 113-124]. it is now demonstrated that the p85 glycoprotein is homologous to the f10-44-2 antigen, defined initially as a t-lymphocyte-granulocyte-brain antigen [dalchau et al. (1980) eur. j. immun. 10, 745-749], the a1g3 h ... | 1986 | 2427941 |
| hla-b27m1m2 and high immune responsiveness to shigella flexneri in post-dysenteric arthritis. | the heterogeneous hla-b27 antigen is closely associated with post-infectious or reactive arthritis (rea) and is comprised of two serologically defined variants: b27m1+m2+ and b27m1+m2-. an outbreak of dysentery (n = 120) caused by a shigella flexneri 2a strain, which possessed cell envelope antigens with epitopes resembling b27m2, resulted in five b27m1+m2+ patients with rea. the remaining seven b27m1+m2+, one b27m1+m2- and all but three b27-negative patients remained free of joint symptoms; the ... | 1986 | 2428743 |
| colonization, virulence, and mucosal interaction of an enteropathogenic escherichia coli (strain rdec-1) expressing shigella somatic antigen in the rabbit intestine. | the group factor 3,4 somatic antigen was transferred by recombination from a donor strain of shigella flexneri type 2a to the escherichia coli o15 rabbit pathogen strain rdec-1. a hybrid clone (7482-1-1) that expressed only the s. flexneri 3,4 somatic antigen and a second clone (7482-1-7) from the same mating mixture that expressed only the o15 somatic antigen were compared for virulence in rabbits. the 7482-1-1 strain produced diarrhea in 10% of rabbits versus 84% for the 7482-1-7 strain (p les ... | 1986 | 2430026 |
| induction in rats of lysine imbalance by dietary homoarginine. | the use of dietary homoarginine (ha) to produce a lysine imbalance was examined in young rats. ha, a basic amino acid analogue, was shown earlier to compete with lysine for transport across the blood-brain barrier. feeding a diet limiting in lysine and containing ha reduced food intake and growth; increasing dietary lysine content lessened these effects. a 3-fold increase in dietary lysine caused 10, 4, 20 and 50-fold increases in lysine concentrations in plasma, brain, liver and muscle, respect ... | 1986 | 2430077 |
| an activated harvey ras oncogene produces benign tumours on mouse epidermal tissue. | studies of the mutagenic action required for specific chemicals to produce benign or malignant tumours suggest that in mouse skin at least two genetic events occur before carcinoma formation. the isolation of an activated form of the c-rash gene from skin papillomas has provided evidence that this gene may be a target for the first mutation, which could constitute the initiating mutation in skin carcinogenesis. in vitro studies indicate that the v-rash gene of harvey murine sarcoma virus (ha-msv ... | 1986 | 2430189 |
| [synthesis of a repeating unit and the dimer of the repeating unit of the major chain of shigella flexneri o-antigen polysaccharide]. | methyl glycoside of the tetrasaccharide glcnac(beta 1-2)rha(alpha 1-2)rha(alpha 1-3)rha, which represents a repeating unit of the basic chain of shigella flexneri o-antigenic polysaccharides, was synthesized using acylated monosaccharide synthons. a dimer of the repeating unit, octasaccharide [glcnac(beta 1-2)rha(alpha 1-2) rha(alpha 1-3)rha(alpha 1-3)]2-ome was obtained by trclo4-catalyzed condensation of two tetrasaccharide blocks. | 1986 | 2430581 |
| lack of correlation between hla-b27 like antigenic epitopes on shigella flexneri and the occurrence of reactive arthritis. | 1986 | 2430745 | |
| [intergeneric antigenic relation of hafnia and shigella (s. flexneri and s. boydii) bacteria]. | the o-antigenic relationships between hafnia and shigellae (s. flexneri and s. boydii) have been studied. for the first time the presence of antigenic relationship between hafnia o19, o4, o9, o33, o5, o16, o12, o7, o29, o28, o10, o32, o24, o25, o18, o1, o13, o3, o22, o30, o37, o14, o11, o25, o23, o21, o28, o16, o24, o8, o26, o27 and s. flexneri la, lb, 2a, 2b, 4a, 4b, 6, 5a, 5b, as well as between hafnia o10, o21, o35, o36, o9, o28, o8, o30 and s. boydii 1, 3, 6, 14, 2, 5, 2, 12 have been reveal ... | 1986 | 2431565 |
| in situ hybridization methods for the detection of somatostatin mrna in tissue sections using antisense rna probes. | in situ hybridization studies with [32p] and [3h] labelled antisense rna probes were undertaken to determine optimal methods of tissue fixation, tissue sectioning, and conditions of hybridization, and to compare the relative merits of the two different radioactive labels. the distribution of somatostatin mrna in neurons of rat brain using a labelled antisense somatostatin rna probe was employed as a model for these studies. the highest degree of sensitivity for in situ hybridization was obtained ... | 1986 | 2435682 |
| interaction studies in mice of sch 29851, a potential non-sedating antihistamine, with commonly used therapeutic agents. | sch 29851 was studied for its ability to interact with selected drugs used in man. the non-sedating antihistamine terfenadine and the sedating antihistamine diphenhydramine were also studied for comparison. sch 29851 at 80 mg/kg po in mice, a dose about 50 times its ed50 for blocking histamine-induced paw edema in the same species, potentiated the anticonvulsant effects of diazepam. at the high dose of 320 mg/kg po, about 80 times its ed50 for antihistamine effects, sch 29851 potentiated the abi ... | 1986 | 2945410 |
| effect of mononuclear cell factors on calcium transport in sarcoplasmic reticulum vesicles. | the effect of supernatants from cultures of mitogen-stimulated human mononuclear cells on calcium transport by sarcoplasmic reticulum was examined. calcium transport was assayed by measuring the time course of calcium accumulation by sarcoplasmic reticulum incubated with supernatants from stimulated mononuclear cells was 20% less than that by vesicles exposed to control supernatants (p less than 0.001). in contrast, no difference in calcium-dependent atpase activity was noted between vesicles in ... | 1986 | 2946307 |
| structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model. | physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ... | 1986 | 2946570 |
| structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model. | physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ... | 1986 | 2946570 |
| docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. | the docosahexaenoic acid (dha) status of preterm infants (less than 32 wk gestation) was measured as the molar percent of dha in individual red blood cell phospholipids: 1) in cord venous blood immediately following delivery, 2) after infants were receiving greater than 60 kcal x kg x day of energy from oral-gastric feedings, and 3) at a mean of 7 wk later. infants on full feeding received either preterm human milk or formula. the dha concentration of all phospholipid classes declined between bi ... | 1986 | 2947455 |
| [effects of my-5116 on experimental animal models of type i-type iv allergic reactions and the formation of ige antibody]. | the effects of a new anti-allergic agent, my-5116: isoamyl 5,6-dihydro-7,8-dimethyl-4,5-dioxo-4h-pyrano [3,2-c] quinoline-2-carboxylate, on experimental animal models of type i approximately type iv allergic reactions and the formation of ige antibody were investigated. my-5116 administered intraperitoneally at doses of 30 and 100 mg/kg suppressed significantly the homologous pca in guinea pigs. my-5116 administered intraperitoneally at the dose of 100 mg/kg also suppressed significantly the het ... | 1986 | 2947841 |
| cnbr cleavage of the light chain of human complement factor i and alignment of the fragments. | the light chain and heavy chain of reduced and alkylated human complement factor i were purified by high-pressure gel-permeation chromatography. cnbr cleavage of factor i light chain yielded four major fragments, which were purified by gel filtration. n-terminal sequence analysis of the cnbr-cleavage fragments allowed identification of 200 of the approx. 240 amino acid residues of the light chain. an alignment is proposed, based on sequence analysis of peptides obtained after cleavage at arginin ... | 1986 | 2937401 |
| effects of heparan sulfate removal on attachment and reattachment of fibroblasts and endothelial cells. | human skin fibroblasts and calf aorta endothelial cells were grown as tissue culture monolayers in the presence of [35s]sulfate in order to label the glycosaminoglycan portions of proteoglycans for investigation of their role in cell attachment. the [35s]glycosaminoglycans were then selectively removed from the cell monolayers by the addition of various glycosaminoglycan-degrading enzymes. as previously described, in contrast to trypsin treatment none of these enzymes removed any cells from the ... | 1986 | 2937448 |
| chromophore/protein interaction in bacterial sensory rhodopsin and bacteriorhodopsin. | retinal analogues with altered conjugated double bond systems or altered stereochemistry were incorporated into the phototaxis receptor sensory rhodopsin (sr) and the light-driven proton pump bacteriorhodopsin (br) from halobacterium halobium. wavelength shifts in absorption ("opsin shifts") due to analogue interaction with the protein microenvironment demonstrate that the same overall electrostatic and steric properties of the retinal binding-site structures exist in both proteins despite their ... | 1986 | 2937462 |
| cultured human endothelial cells synthesize a plasma membrane protein complex immunologically related to the platelet glycoprotein iib/iiia complex. | we have previously demonstrated that endothelial cells synthesize a plasma membrane protein indistinguishable from platelet glycoprotein (gp) iia. the present study provides evidence for a further analogy between the platelet and the endothelial cell membrane by showing that cultured endothelial cells also synthesize a membrane protein complex immunologically related to the platelet gp iib/gp iiia complex. this evidence is based on the following observations: (1) c17, a murine monoclonal antipla ... | 1986 | 2937471 |
| a follow up of t-cell subsets and of anti-m. leprae antibody titer as measured by the fla-abs test in melanesian leprosy patients under polychemotherapy. | melanesian leprosy patients from new caledonia were studied for the following parameters during the course of polychemotherapy: peripheral blood t-cell subsets, as identified in an immunofluorescence assay with monoclonal antibodies okt3 ("pan-t"), okt4 ("helper/inducer"), and okt8 ("cytotoxic-suppressor"), and anti-mycobacterium leprae antibodies in the serum, as measured by the fluorescent leprosy antibody absorption test. a group of melanesian healthy subjects with no known exposure to m. lep ... | 1986 | 2940306 |
| [risk factors in the epidemiology of dysentery]. | the general tendency of a decrease in the morbidity rates of dysentery induced by shigella sonnei and shigella flexneri (separately) from monday to the end of the week (saturday-sunday) has been revealed, and at the same time the "infection risk" for both kinds of salmonellosis has been found to fall on the last days of the week (friday-sunday). | 1986 | 2940778 |
| dose-related effects of synthetic human beta-endorphin and naloxone on fed gastrointestinal motility. | in humans, plasma beta-endorphin levels rise during application of acute stressful stimuli (vertigo, cold pain, and transcutaneous electrical stimulation) that induce gut motor disturbances. whereas it is possible that circulating beta-endorphin participates in the mediation of these central effects on gut motility, its role cannot be established solely on the basis of changes in plasma levels. therefore, we designed the present study to investigate 1) the dose-related effects of intravenous syn ... | 1986 | 2942039 |
| isolation, characterization and utilization of the fifth component (c5) of porcine complement. | the fifth component (c5) of porcine complement was isolated in immunochemically pure, homogeneous and native form. the isolated component was characterized, it has a molecular weight of 187,000 (under non-reducing conditions) and two non-identical chains of 112,000 and 76,000 under reducing conditions, respectively. the isolated c5 can be used for the detection of the c5b receptors on murine macrophages. our findings are in good agreement with the results obtained using a rabbit and a human mode ... | 1986 | 2943607 |
| ultracytochemical evidence for a proton-pump adenosine triphosphatase in chick osteoclasts. | the distribution of mg++-atpase in osteoclasts along the endosteal surface of the chick tibia was investigated by neutral and alkaline ph cytochemical methods at the electron-microscopic level. reaction product was observed in mitochondria, cytoplasmic vesicles, and ruffled-border membrane. levamisole, ouabain, and vanadate did not affect the enzymatic activity. para-chloromercuribenzoic acid (pcmb) prevented staining of mitochondria, ruffled border, and most cytoplasmic vesicles. tri-n-butyltin ... | 1986 | 2944590 |
| intestinal bacterial flora and host defense mechanisms. | the protective mechanisms of intestinal bacterial flora against exogenous infections will be discussed in this paper. experimental data on protective function of escherichia coli, enterococcus faecalis and bacteroides distasonis comprising intestinal flora against oral infection of shigella flexneri which causes localized infection are presented. furthermore, the present investigation deals with non-specific defense mechanism which indicate that protective activity of intestinal flora against pa ... | 1986 | 2968005 |
| hormonal control of polyamine levels in bovine adrenocortical cells. | the implication of polyamines in cellular growth and differentiation processes and the existence of a polyamine-mediated protein phosphorylation system in adrenocortical cells suggest that polyamines may be examined as potential intracellular messengers in the pleiotypic action of acth. bovine adrenocortical cells in culture exhibit a specific, energy-dependent, partly sodium-supported, inward polyamine transport system, independent of the a, l, and n aminoacid uptake systems. steroidogenic conc ... | 1986 | 3004891 |
| studies on the glycoprotein nature of the thyrotropin receptor: interaction with lectins and purification of the bovine protein with the use of bandeiraea (griffonia) simplicifolia i affinity chromatography. | the tsh receptor from triton-solubilized bovine microsomal membranes was found to bind to a substantial extent to columns of the immobilized lectins bandeiraea (griffonia) simplicifolia i, ricinus communis i, wheat germ, and concanavalin a, whereas it was not retained by dolichos biflorus. elution of tsh receptor activity from these lectins could be achieved with the appropriate saccharides in all cases except concanavalin a. the most extensive adsorption of the receptor occurred on b. simplicif ... | 1986 | 3004903 |
| [similar organization of beta,beta'-subunit rna-polymerase genes and adjacent ribosomal protein genes in enterobacteriaceae and pseudomonas putida]. | the genes coding for the rna-polymerase beta,beta'-subunits and adjacent ribosomal protein genes in escherichia coli, salmonella typhimurium, shigella flexneri, serratia marcescens, proteus mirabilis and pseudomonas putida are compared by the southern hybridization procedure. in all the species studied close clustering of the genes rplkajl and rpobc is demonstrated. preliminary physical maps for these genes in s. typhimurium, s. flexneri, s. marcescens and p. mirabilis are proposed. rifampicin i ... | 1986 | 3005845 |
| enteropathogens associated with acute diarrhea in hospitalized infants. | thirty-five infants of low socioeconomic status who were living in urban santiago were hospitalized for acute diarrhea were prospectively evaluated for the presence of enteropathogens associated with the episode. some degree of malnutrition was evident in 20 infants (57.1%); 15 of these (75%) were under 6 months of age. mean duration of the hospital stay was 11.8 days for well-nourished patients and 15.7 days for the malnourished patients. one or more enteropathogens were found in 60% of the cas ... | 1986 | 3007718 |
| complete dissociation between the activation of phosphoinositide turnover and of nadph oxidase by formyl-methionyl-leucyl-phenylalanine in human neutrophils depleted of ca2+ and primed by subthreshold doses of phorbol 12,myristate 13,acetate. | evidences have been provided by many laboratories that the activation of the nadph oxidase in neutrophils by formyl-methionyl-leucyl-phenylalanine (fmlp) is strictly linked to a transduction pathway that involves the stimulation, via gtp binding protein, of the phosphoinositide turnover and the increase in [ca2+]i. the results presented in this paper demonstrate that fmlp can activate the nadph oxidase by triggering a transduction pathway completely independent of phosphoinositide turnover and c ... | 1986 | 3008746 |
| identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the l component of herpes simplex virus genome. | in the course of studies on the a sequences located at the termini of and at the junction between the l and s components of herpes simplex virus 1 dna, j. chou and b. roizman (j. virol. 57:629-637, 1986) noted that the a sequence acted as a gamma 1 promoter when fused to the structural sequence of the thymidine kinase gene, the b inverted repeat sequences located in the l component next to the a sequences contained an open reading frame predicted to encode the protein of 358 amino acids with a m ... | 1986 | 3009891 |
| radioreceptor assay of anti-tsh receptor antibody activity: comparison of assays using unextracted serum and immunoglobulin fractions, and standardization of expression of activities. | a radioreceptor assay for tsh receptor antibodies developed by shewring and smith is described in which unextracted serum is used. the assay is simple and reproducible. tsh-binding inhibitor immunoglobulin (tbii) activity determined using unextracted serum correlated well with that determined using the immunoglobulin fraction purified with polyethylene glycol. the assay detected tsh receptor antibodies in 81 of 85 patients (95%) with untreated graves' disease, no patients with graves' disease in ... | 1986 | 3016274 |
| anti-htlv-iii screening of blood donors. | in a survey on 82,383 blood donor specimens from hessen, west germany, the observed percentage of repeatedly positive htlv-iii/lav antibody elisa results was 0.2%, but only 0.018% were confirmed by western blot, immunofluorescence assay or radioimmunoprecipitation assay. these data are consistent with larger epidemiological data compiled from other german blood banks and suggest a high degree of nonspecific false-positive results; one of the causes for false-positives are hla-dr4 antibodies, whi ... | 1986 | 3017001 |
| effects of theophylline and camp on amphiuma small intestine. | 1986 | 3017122 | |
| effect of age on the formation of cyclic nucleotides in guinea-pig tracheal smooth muscle in response to pharmacological agents. | the effects of isoproterenol, carbachol and other drugs on the cyclic amp and cyclic gmp levels in tracheal smooth muscles of guinea-pigs of four different ages were investigated. isoproterenol increased the cyclic amp level several-fold in tracheal muscles from newborn (1 week) and young (4-7 weeks) guinea-pigs, but it caused less increase in the level in muscles from middle-aged (12 weeks) and old (20-24 weeks) guinea-pigs, although the basal cyclic amp level at these ages was not significantl ... | 1986 | 3017724 |
| steroid-responsive bronchiolitis after human heart-lung transplantation. | this report describes the clinical course of a patient who developed obliterative bronchiolitis after viral infection on three separate occasions. long-term follow-up is given. it is suggested that the syndrome of late pulmonary deterioration after transplantation may be steroid responsive if treatment is initiated early in the natural history of the syndrome. in addition, it is suggested that increased emphasis should be placed on the documentation of viral infection in transplant recipients to ... | 1986 | 3018383 |
| testing for htlv-iii/lav antibody. | 1986 | 3019171 | |
| studies on the antihypertensive effect of single doses of the angiotensin converting enzyme inhibitor ramipril (hoe 498) in man. | the time course of the blood pressure lowering effect and the dose-response relationship of the new angiotensin converting enzyme inhibitor ramipril (hoe 498) were studied in 8 patients, with essential hypertension. as compared with placebo, a single oral dose of 2.5 mg ramipril lowered systolic and diastolic blood pressure. the antihypertensive action of single oral doses of 5, 7.5 and 10 mg ramipril was more pronounced. no change in heart rate occurred. angiotensin converting enzyme activity w ... | 1986 | 3019702 |
| studies on the antihypertensive effect of single doses of the angiotensin converting enzyme inhibitor ramipril (hoe 498) in man. | the time course of the blood pressure lowering effect and the dose-response relationship of the new angiotensin converting enzyme inhibitor ramipril (hoe 498) were studied in 8 patients, with essential hypertension. as compared with placebo, a single oral dose of 2.5 mg ramipril lowered systolic and diastolic blood pressure. the antihypertensive action of single oral doses of 5, 7.5 and 10 mg ramipril was more pronounced. no change in heart rate occurred. angiotensin converting enzyme activity w ... | 1986 | 3019702 |
| animal models for retrovirus-induced immunodeficiency disease. | 1986 | 3019879 |