Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| safety and immunologic effects after inoculation of inactivated and combined live-inactivated dermatophytosis vaccines in cats. | to determine antidermatophyte immunologic effects of an experimental combined live-inactivated dermatophytosis vaccine (clidv) and a commercial inactivated dermatophytosis vaccine (idv) in cats and to evaluate adverse effects associated with administration of these vaccines. | 2002 | 12428663 |
| fluconazole downregulates metallothionein expression and increases copper cytotoxicity in microsporum canis. | azole antifungals are widely used to treat infections with dermatophyte fungi. whereas it is well established that this class of drugs interferes with fungal ergosterol synthesis, little is known about its potential other biological effects. here we report the isolation and structural organization of microsporum canis metallothionein gene and demonstrate that fluconazole is able to downregulate the baseline as well as copper-induced expression of this gene. since this effect occurred within 30 m ... | 2002 | 12470632 |
| involvement of tnf-alpha changes in human cancer development, prevention and palliative care. | cancer development and ageing are complex sciences. from the study on the process of rodent carcinogenesis, we identified tumor necrosis factor-alpha (tnf-alpha) as an important mediator of cancer development. this paper presents three clinical examples of tnf-alpha up-regulation: by cord factors of mycobacterium tuberculosis, such as trehalose 6-monomycolate, as an activator of protein kinase c and by a cord factor like fraction of microsporum canis obtained in the air inside houses in thailand ... | 2002 | 12470903 |
| fungal flora of human toe webs. | a total of 100 young adults (67 males and 33 females) participated in the study. clinical evaluation showed that only 10 of the volunteers showed some scaling, fissuring and peeling of the toe webs. four of these complained of occasional itching. fourteen different genera of fungi were recovered from 78 of the 100 youths screened. yeasts were recovered from 21 (27%) of the positive cases, nondermatophytes from 38 (49%) and dermatophytes from 19 (24%). microsporum gypseum was the most commonly re ... | 2002 | 12472726 |
| case report. tinea corporis due to microsporum canis in a professional cyclist. | we report the case of a 20-year-old man, a professional cyclist, with multiple scaling plaques on his limbs that had been present for 40 days. our case of tinea corporis presented some peculiarities related to the aetiological agent microsporum canis and also its mode of transmission. | 2002 | 11856439 |
| [dermatophyte flora at the dermatology clinic of kimitsu chuo hospital from 1994 through 1999]. | kimitsu chuo hospital is located in the middle of chiba prefecture along tokyo bay. an epidemiological survey of dermatophytosis was made at the dermatology clinic of the hospital from january 1994 through december 1999. dermatophytosis patients numbered 2,580 and disease types were composed of: tinea pedis 1,656 (64.2%), tinea unguium 377 (14.6%), tinea corporis 308 (11.9%), tinea cruris 139 (5.4%), tinea manuum 92 (3.6%), tinea capitis 6 (0.2%) and tinea profunda 2 (0.1%). species frequencies ... | 2002 | 11865297 |
| topical treatment of tinea capitis in a neonate. | tinea capitis is the most common fungal skin infection in children. given that this infection invades the hair shaft and the pilosebaceous unit, systemic antifungal therapy is the gold standard of treatment. despite the neonate's increased susceptibility to infections, tinea capitis is rare in this population. we present the case of a 16-day-old infant with tinea capitis caused by microsporum canis and effectively treated with topical bifonazole 1%. | 2002 | 11868981 |
| [epidemiology and etiology of dermatophytosis in goiânia, go, brazil]. | dermatophytes are a group of closely related fungi that have the capacity to invade keratinized tissue (skin, hair, and nails) of humans and animals to produce infections called dermatophytosis. in order to review the etiology and epidemiology of dermatophytosis in goiânia, go, 1955 specimens with diagnostic suspicion of dermatophytic lesions, were collected from january to december, 1999, from the mycology laboratory in the institute of tropical pathology and public health, federal university o ... | 2002 | 11873256 |
| evaluation of topically applied enilconazole for the treatment of dermatophytosis in a persian cattery. | many persian catteries have long-standing dermatophyte infections and are particularly difficult to treat. enilconazole is a topical antifungal agent that has demonstrated good efficacy in recent studies. twenty-two persian cats naturally infected with microsporum canis in a breeding cattery were treated with topical 0.2% enilconazole and monitored for 180 days. the treatments were repeated every 3 days for a total of eight applications. all the cats improved clinically and became culture negati ... | 2002 | 11896967 |
| synthesis of variously 9,9-dialkylated octahydropyrimido [3,4-a]-s-triazines with potential antifungal activity. | 9,9-dialkyloctahydropyrimido[3,4-a]-s-triazines were synthesized by iminodimethylation reaction between a 5,5-dialkyl-6-aminopyrimidine-2.4(3h,5h)-dione, a substituted aniline and two moles of formaldehyde. the synthesis of.5,5-dialkyl-6-aminopy-rimidinedione consisted of the condensation of urea with ethyl 2,2-dialkylcyanoacetates. 18 octahydropyrimido[3,4-a]-s-triazines were synthesized and compounds resulting from a supplementary aminomethylation were also obtained. most of these compounds we ... | 2002 | 11902652 |
| subcutaneous infection by microsporum gypseum. | we report a case of subcutaneous infection caused by the dermatophyte microsporum gypseum in an immunocompetent host. the patient acquired the infection in the knee through a traumatic inoculation of a splinter. to our knowledge this is the first case of subcutaneous infection caused by this fungus. | 2002 | 11903246 |
| fungi isolated from skins and pens of healthy animals in nigeria. | the mycoflora of 220 skin scrapings, hair, nail samples and pens' materials of apparently healthy animals including cows, sheep, goats, rabbits, pigs and dogs were determined. twenty eight species of fungi belonging to ten genera were recovered. chrysosporium spp. were the most common and c. keratinophilum was recovered from all animals. dermatophytes which are known causal agents of dermatophytosis were also isolated in different frequencies (microsporum gypseum, m. canis, trichophyton mentagro ... | 2002 | 11913761 |
| further evaluation of rwandan medicinal plant extracts for their antimicrobial and antiviral activities. | a total of 45 rwandan plant extracts, belonging to 37 different plant species out of 21 families, were investigated for their antibacterial, antifungal, and antiviral properties. the plants were selected on the base of their ethnomedicinal use against infections and autoimmune diseases. from all the plant extracts tested, only clematis hirsuta (leaves) showed a pronounced antifungal activity against candida albicans and the dermatophytes trichophyton rubrum, epidermophyton floccosum, and microsp ... | 2002 | 11801376 |
| antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin. | the phytoalexin resveratrol is commonly found in food and drinks, including red wine, grapes, and peanuts. many studies have shown that this compound has anti-inflammatory properties, and it has been ascribed as having health benefits that help to prevent cancer and coronary heart disease. a treatment that combines antimicrobial and anti-inflammatory actions may be desirable for alleviating many skin conditions that range in severity. therefore, we evaluated the antimicrobial activity of resvera ... | 2002 | 11841782 |
| sensitivity of ornithophillic fungi to some drugs. | the occurrence of ornithophillic fungi and related dermatophytes was evaluated from the poultry farm soil samples. two test species of microsporum were tested by 'spore germination' and 'disc diffusion method' against the two well known antifungal antibiotics i.e. griseofulvin and mycostatin (polyene antibiotic). the data showed cent percent inhibition of fungal spore germination and increased zone of inhibition at higher doses. the antimicrobial drugs including acetyl salicylic acid, benzoic ac ... | 2002 | 15061595 |
| [tinea capitis by microsporum audouinii]. | we report the case of a four year-old girl from equatorial guinea who had been living in spain for the last month. she presented several alopecic patches on the scalp. the direct study of the hair with 40% koh showed an ectothrix infection and the mycological study revealed the etiologic agent was microsporum audouinii. we present this case because of its rarity in our country and we point out the increasing interest of the imported tineas due to immigration from african countries. | 2001 | 15487914 |
| [mixed dermatophyte infection in a cat]. | skin mycoses in animals are mostly caused by microsporum canis, microsporum persicolor, microsporum gypseum and in rare cases by trichophyton mentagrophytes. as a rule only one dermatophyte species is isolated from skin lesions, but at times mixed infection with bacteria occur. in the described case in a cat with typical dermatomycosis, microsporum canis and trichophyton mentagrophytes were isolated simultaneously. to the best of our knowledge this is the first case of mixed dermatophyte infecti ... | 2001 | 16886403 |
| [the enzymatic activity of fungi strains isolated from the skin and skin appendages of humans returning from the tropics]. | the aim of the work was to assess the enzymatic activity of 11 fungi strains isolated from the skin of 10 lódź residents who had visited the tropics over 1998-1999. the strains were cultured by jeske and lupa of the voivodeship outpatient clinic of infectious, parasitic and tropical diseases and fungal infections in lódź. they were as follows: trichophyton rubrum and acremonium kiliense from zambia, myriodontium keratinophilum, beauveria bassiana, cladosporium herbarum, candida famata and tricho ... | 2001 | 16886418 |
| efficacy of itraconazole as a combined continuous/pulse therapy in feline dermatophytosis: preliminary results in nine cases. | this study evaluated the efficacy of itraconazole as a combined continuous/pulse therapy for feline dermatophytosis. nine cats with dermatophytosis caused by microsporum canis were treated with itraconazole at 10 mg kg(-1) orally once daily for 28 days and then on an alternate week regimen (1 week off, 1 week on) at the same dosage. cats were re-evaluated by physical examination and fungal culture at days 28, 42, 56 and 70 if necessary. treatment was stopped when two consecutive negative fungal ... | 2001 | 11844225 |
| [fungistatic activity of a sesquiterpene lactone (tomentosin) isolated from fresh inula viscosa (asteraceae) flowers from the puglia region]. | a sesquiterpene lactone, tomentosin, has been isolated and identified form inula viscosá ait (asteraceae) flowers. the molecule, at 1 mg/ml concentration, showed to be active in vitro against microsporum canis, microsporum gypseum and trichophyton mentagrophytes. | 2001 | 11921538 |
| phenotypic characterization of microsporum canis isolated from cats and dogs. | to characterize strains of microsporum canis that infect dogs and cats in são paulo city, 30 isolates of this dermatophyte were tested for their ability to assimilate carbon and nitrogen sources, for proteinase and phospholipase secretion, for susceptibility to yeast killer toxins, and for susceptibility to the antifungals fluconazole, ketoconazole, itraconazole, 5-fluorocytosine and amphotericin b, in e test. all samples assimilated the nitrogen sources asparagine, ammonium sulphate, urea and s ... | 2001 | 11820261 |
| dermatophytoses in prague, czech republic, between 1987 and 1998. | over a 12-year period, from 1987 to 1998, the spectrum of aetiological agents isolated from 11208 patients (6265 females and 4943 males) suspected of having dermatomycosis was analysed in the mycological laboratory of the department of dermatology, charles university, prague. the most frequently examined locations were toenails (34.9%), feet (15.6%), fingernails (12.8%), toe webs (11%), trunk (10%) and hands (8.7%). dermatophytes were isolated from 5605 (30.2%) of all 18528 samples examined. amo ... | 2001 | 11820263 |
| synthesis of some 4-(alkylidene/arylidene)amino-2,4-dihydro-5- (2-thienyl)-3h-1,2,4-triazole-3-thiones tested for antimicrobial activity. | a series of 4-(alkylidene/arylidene)amino-2,4-dihydro-5- (2-thienyl)-3h-1,2,4-triazole-3-thiones (2a-h) were synthesized. the structural elucidation of all the compounds was made on the basis of analytical and spectral data (ir, 1h-nmr and eims). all synthesized compounds were evaluated for in vitro antimicrobial activity against various bacteria and fungi. some of the compounds demonstrated antimicrobial activity against staphylococcus aureus atcc 6538, staphylococcus epidermidis atcc 12228, tr ... | 2001 | 11822231 |
| tinea capitis in infants less than 1 year of age. | tinea capitis is the most frequent manifestation of dermatophyte infection in children, but because it is rare in the first months of life it is often misdiagnosed. here we report 15 cases of tinea capitis observed in italy in infants less than 1 year of age. there were 10 boys and 5 girls (mean age 6 months). diagnosis was confirmed by mycologic examination. microsporum canis was isolated in nine cases and trichophyton mentagrophytes in three. these 12 infants were italian and animals were the ... | 2001 | 11841628 |
| itraconazole is effective in the treatment of tinea capitis caused by microsporum canis. | tinea capitis is a relatively common superficial fungal infection in children which requires oral antifungal therapy. in a prospective, open study over 24 weeks, itraconazole 5 mg/kg/day, given as capsules or as an oral suspension for a period of 2-12 weeks, was used to treat children 1-12 years of age who had m. canis tinea capitis. children with mycologic evidence of m. canis tinea capitis were entered into the study and asked to return at week 2 and then every 2 weeks thereafter until cured, ... | 2001 | 11841643 |
| terbinafine hydrochloride treatment of microsporum canis experimentally-induced ringworm in cats. | cats represent the most important source of microsporum canis infection to people. terbinafine hydrochloride is commonly used in the treatment of microsporosis. its fungicidal action permits short period of treatment. it was our objective to evaluate the effectiveness of this drug in treatment of microsporosis in cats. we treated nine experimentally m. canis infected cats with terbinafine at a dose of 10-20mg/kg sid (low-dose group, ldg), nine cats with 30-40mg/kg sid (high-dose group, hdg), and ... | 2001 | 11557156 |
| bioactive compounds from iostephane heterophylla (asteraceae). | the novel bisabolene sesquiterpenes 3-6, were isolated from iostephane heterophylla, using bioguided fractionation. the new compounds were determined to be (12r/12s)-12,13-epoxy-xanthorrhizols (3,4) and (12r/12s)-12,13-dihydro-12,13-dihydroxy-xanthorrizols (5,6) and their structures were characterized by analysis of spectroscopic data and by chemical correlation from xanthorrhizol (2). the stereochemistry at c-12 of 5 was deduced using the modified mosher experiment. some of the isolated compoun ... | 2001 | 11561451 |
| doubled dose of oral terbinafine is required for microsporum canis tinea capitis. | fourteen children, ages 1-15 years, with microsporum canis tinea capitis were given oral terbinafine for 4 weeks at the recommended daily dose according to their weight: 10-20 kg, 62.5 mg; 20-40 kg, 125 mg; > 40 kg, 250 mg. because none of the patients had clinically responded to treatment by week 4 the dose of terbinafine was doubled (up to 250 mg) for an additional 4-8 weeks in six patients, and continued at the original dose in six patients. two patients dropped out of the study. on final eva ... | 2001 | 11576412 |
| in vitro activity of tea tree oil against candida albicans mycelial conversion and other pathogenic fungi. | the antifungal activity of melaleuca alternifolia maiden (myrtaceae) essential oil against yeasts (candida spp., schizosaccharomyces pombe, debaryomyces hansenii) and dermatophytes (microsporum spp. and tricophyton spp.) is reported. we focused on the ability of tea tree oil to inhibit candida albicans conversion from the yeast to the pathogenic mycelial form. moreover we carried out broth microdilution test and contact tests to evaluate the killing time. m. alternifolia essential oil inhibited ... | 2001 | 11589479 |
| in vitro activity of posaconazole against clinical isolates of dermatophytes. | a broth macrodilution method following the recommendations established by the national committee for clinical laboratory standards was used to compare the in vitro activity of posaconazole (pcz) with that of itraconazole (itc) against 30 clinical isolates of dermatophytes belonging to six different species. in terms of mics, pcz showed an activity equal to that of itc. mics of pcz at which 50% (mic(50)) and 90% (mic(90)) of the isolates were inhibited were 0.5 and > 4.0 microg/ml, respectively. ... | 2001 | 11682563 |
| tinea capitis in europe: new perspective on an old problem. | a survey of tinea capitis conducted under the auspices of the european confederation of medical mycology showed that laboratories contributing to a voluntary scheme for reporting have recently been seeing a different pattern of scalp ringworm. the survey was conducted among 92 medical mycology laboratories across 19 european countries by postal questionnaire comparing the years 1987 with 1997. the survey shows an overall increase in the numbers of cases caused by anthropophilic infections, which ... | 2001 | 11683286 |
| novel oxindole derivatives and their biological activity. | the antifungal activity of fourteen novel derivatives of oxindole with side chain was studied using representatives of toxinogenic, phytopathogenic and dermatophytic filamentous fungi. derivatives with exocyclic c=c bond in position c-3 exhibited a higher antifungal activity compared with derivatives with an exocyclic c-c bond in the same position. the strongest antifungal effects were shown by 3-(-2-thienoylmethylidene)-indol-2(3h)-ones. | 2001 | 11702401 |
| [an epidemiological study for fungus isolation during the twenty-five year periods from 1976 to 2000 in kitasato university hospital]. | we investigated an epidemiological study for fungus isolation in our hospital from 1976 to 2000. for 25 years, the total sample number of fungus examination were 64,296, and after 1988, the total sample number increased suddenly. as a whole, the positive ratio was constantly about 40%. when our hospital opened, the obstetrical and gynecological samples showed 38.8% for fungus examination, but recently, samples of the respiratory organ has increased. ratio of isolation for yeast, candida albicans ... | 2001 | 11712361 |
| microsporum gypseum isolated from a feline case of dermatophytosis. | the 1- to 2-month-old female cross-breed cat presented with alopecia, erythema and many crusts were present on the tail. microscopic examination of crusts from the tail disclosed epithelial debris, exudate, mycelium, and arthrospores. microsporum gypseum which is rarely isolated from cats as a causative agent of dermatophytsis was cultured from the crusts on a 1/10 sabouraud glucose agar at 27 degrees c for 1 week. the isolate of m. gypseum from the cat was examined by random amplification of po ... | 2001 | 11714073 |
| pseudomycetoma caused by microsporum canis in a persian cat: lack of response to oral terbinafine. | an eight-year-old neutered female persian cat with a four-year history of relapsing skin disease, characterised by ulcerated nodules with a yellow granular discharge, was examined. a diagnosis of granulomatous dermatitis and panniculitis (pseudomycetoma) caused by microsporum canis was made on the basis of history, clinical signs, histopathological examination of skin biopsy specimens and culture of macerated tissue. because previous therapy, comprising repeated surgical excision and the adminis ... | 2001 | 11721986 |
| atypical tinea corporis caused by microsporum gypseum in a subject with acquired immune deficiency syndrome. | 2001 | 11730066 | |
| tinea capitis in two young women: possible favouring role of hair styling products. | 2001 | 11730067 | |
| antifungal principles from piper fulvescens. | activity-guided fractionation of the dichloromethane extract from leaves of piper fulvescens, using an agar overlay bioautographic method, led to the isolation of three antifungal neolignans identified as conocarpan, eupomatenoid 5 and eupomatenoid 6. the minimal inhibitory concentration of these three neolignans against five fungi strains were determined. conocarpan showed the widest activity, whereas eupomatenoid 6 was the most active against dermatophytes. | 2001 | 11745030 |
| determination of terbinafine hydrochloride in cat hair by two chromatographic methods. | terbinafine hydrochloride (terbhcl) concentration on the site of infection with microsporum canis is a very important indicator of drug effectiveness. several chromatographic methods exist that can be used for the determination of terbhcl concentration in biological samples. a high performance liquid chromatographic (hplc) method and a gas chromatographic (gc) method have been compared and critically evaluated for the determination of a terbhcl levels in cat hair. the sensitivity and the lineari ... | 2001 | 11748682 |
| human hair colonizing fungi in water sediments of india. | out of 144 samples of water sediments, 183 isolates belonging to 9 genera and 22 species were isolated. fifty-nine isolates of acremonium, 26 of chrysosporium indicum, 22 of chrysosporium keratinophilum, 17 of malbranchea sp. and 10 of microsporum gypseum were recovered. acremonium implicatum, chrysosporium georgii, chrysosporium xerophilum and geomyces pannorum were reported for the first time from india. | 2001 | 11761148 |
| tinea capitis in adults during 1981-95 in northern greece. | the mycological laboratory of our hospital examined 31,073 patients between 1981 and 1995. sex, age, the residence of patients, the clinical type of tinea and contacts with other persons and animals were investigated. all the patients were also examined under wood's light. tinea capitis was diagnosed in 35 adults. trichophyton violaceum was the commonest aetiological agent (54.5%), especially in elderly women. the other anthropophilic fungi were t. rubrum (8.5%), t. schoenleinii (5.7%) and t. to ... | 2001 | 11766106 |
| epidemiological study of pathogenic fungi in china: 1986 and 1996. | an annual decade epidemiological survey of pathogenic fungi of inpatients or outpatients includes more than 25 provinces in china has been done in 1986 and 1996. | 2001 | 11780317 |
| proximal subungual hyperkeratosis of the big toe due to microsporum gypseum. | 2001 | 11800151 | |
| tinea cruris due to combined infections of trichophyton mentagrophytes and microsporum canis. a case report. | 2001 | 11800157 | |
| production of extracellular enzymes by microsporum canis and their role in its virulence. | microsporum canis is the most prevalent dermatophyte of domestic animals. several enzymes produced by dermatophytes, particularly keratinases, are considered to play a role in the virulence of this fungus. to investigate the possible relationship between the clinical status of m. canis infection and enzymatic activity of isolates, we studied the relationship between keratinase, elastase, lipase and dnase levels produced in vitro by different isolates and virulence as expressed in a guinea pig mo ... | 2001 | 12054058 |
| endemic scalp ringworm: an object lesson in control of a common fungal infection. | 2001 | 11979119 | |
| chitin synthase 1 (chs1) gene sequences of microsporum equinum and trichophyton equinum. | chitin synthase 1 (chs1) genes from microsporum equinum and trichophyton equinum were compared with those of the other dermatophytes. the chs1 nucleotide sequences of these dermatophytes from horses showed more than 80% similarity to those of arthroderma benhamiae, a. fulvum, a. grubyi, a. gypseum, a. incruvatum, a. otae, a. simii, a. vanbreuseghemii, epidermophyton floccosum, t. mentagrophytes var. interdigitale (t. interdigitale), t. rubrum and t. violaceum. especially high degree of nucleotid ... | 2001 | 11118744 |
| in vitro antifungal activity of schizozygia coffaeoides bail. (apocynaceae) extracts. | leaf extracts of schizozygia coffaeoides were investigated for antifungal activity using the disc diffusion assay technique. petroleum ether 40-60 degrees c, dichloromethane-ethyl acetate (1:1) and methanol extracts were fungitoxic to trichophyton mentagrophytes, microsporum gypseum, cladosporium cucumerinum and candida albicans. the extracts were fungistatic in action. | 2001 | 11137346 |
| [1997 epidemiological survey of dermatophytoses in japan]. | an epidemiological investigation on dermatophytoses in japan for the year 1997 was carried out with the following results. the number of dermatomycoses patients visiting the fourteen cooperating institutes that year was 8,284. new outpatients with this condition accounted for 13.3% of all new outpatients in these institutes. dermatophytoses patients numbered 7,314 and were composed of: tinea pedis 4,901 (63.8%), tinea unguium 1,592 (20.7%), tinea corporis 557 (7.2%), tinea cruris 395 (5.1%), tin ... | 2001 | 11173330 |
| microsporum canis tinea capitis in an 8-month-old infant successfully treated with 2 weekly pulses of oral itraconazole. | we report an 8-month-old girl with tinea capitis caused by microsporum canis which was successfully treated with two pulses of oral itraconazole 50 mg/day, each of 1 week duration with an interval of 2 weeks. m. canis tinea capitis can be a difficult therapeutic problem in an infant, as the treatment is usually long, lasting up to 4-6 weeks with griseofulvin and 6-12 weeks with terbinafine, and the desire to provide a safe systemic therapy is particularly important. with an intermittent regimen ... | 2001 | 11207976 |
| antifungal activity of some mono, bis and quaternary mannich bases derived from acetophenone. | the development of resistance to current antifungal therapeutics drives search for new effective agents. some mannich bases have antifungal activity, but no information is available regarding the antifungal activity of acetophenone derived mannich bases. mono mannich bases of acetophenone 1-3 were synthesized and converted into their corresponding bis derivatives, 5-7. representative quaternary derivatives 4 and 8 were also synthesized. antifungal activities of the compounds were evaluated using ... | 2001 | 11215330 |
| a randomized comparison of 4 weeks of terbinafine vs. 8 weeks of griseofulvin for the treatment of tinea capitis. | tinea capitis is a common childhood infection that has recently become more frequent in urban areas in europe and the u.s.a. the current licensed treatment in children is griseofulvin 10 mg kg(-1) daily, which is usually given for 6--8 weeks. | 2001 | 11251566 |
| immunohistochemical detection of interferon-gamma-producing cells in dermatophytosis. | skin lesions of dermatophytosis are thought to be a result of a t cell-dependent inflammatory response that is mediated by various cytokines. we examined whether ifn-gamma-positive cells (as expression of th1 response) were present in the skin lesions of dermatophytosis in situ by immunohistochemical techniques. mixtures of cd4-positive t cells and cd8-positive t cells were found to be present in the dermal infiltrates of the lesions. considerable numbers of cd1a-positive cells were detected in ... | 2001 | 11275803 |
| tinea capitis in two elderly women: transmission at the hairdresser. | tinea capitis is rare in the elderly. we report cases of two elderly women who presented to our dermatology clinic within 8 weeks of each other, with scalp scaling and alopecia. in both cases, microsporum canis grew on fungal culture of their hair, and required prolonged treatment with terbinafine. neither of them gave a history of contact with young children or any animals. both were fairly fit and not systemically immunocompromised. however, both had been regularly visiting the same hairdresse ... | 2001 | 11298558 |
| species identification system for dermatophytes based on the dna sequences of nuclear ribosomal internal transcribed spacer 1. | this describes a new and reliable species identification and classification system for dermatophytes based on the cluster analysis of nuclear ribosomal internal transcribed spacer 1 (its1) dna sequences. in this system, some phenotypically similar species construct a compact monophyleic cluster which seems to be a species. this its1 sequence based species is called an its1-genospecies. the classification of genospecies is a practical concept for dna sequence based species identification. it is p ... | 2001 | 11331465 |
| [advances in molecular biology of dermatophytes]. | during the 44th meeting of the japanese society for medical mycology in nagasaki, 2000, a forum was held entitled advances in molecular biology of dermatophytes. based on the subject, target molecules and kind of approach, we selected seven presentations from over 100 of the poster abstracts. six of them concerned identification and one concerned viability. summaries of the 7 presentations are given in this article. of presentations on the identification methods, 5 demonstrated their usefulness: ... | 2001 | 11331468 |
| dermatophytoses in children: study of 137 cases. | dermatophytoses are common fungal infections caused by dermatophytes but there are few data about this condition in the childhood. 137 children below the age of 12 and clinically diagnosed as tineas were investigated prospectively at instituto de puericultura e pediatria, rio de janeiro, from 1994 to 1999. hair, skin/nails scraping and pus swabs were collected from lesions and processed for fungus. male children from 2 to 12 years were mostly affected; tinea capitis (78 cases) mainly caused by m ... | 2001 | 11340481 |
| tinea capitis: study of asymptomatic carriers and sick adolescents, adults and elderly who live with children with the disease. | tinea capitis is a dermatophyte infection that occurs mainly in childhood; there are few reports, in brazil, in adolescents and adults. the detection of asymptomatic carriers is of great importance in the disease control. from february 1998 to february 1999, a study was performed at the outpatient dermatologic unit of instituto de puericultura e pediatria martagão gesteira (universidade federal do rio de janeiro, brasil) to verify the frequency of asymptomatic carriers and tinea capitis between ... | 2001 | 11340482 |
| cluster analysis of human and animal pathogenic microsporum species and their teleomorphic states, arthroderma species, based on the dna sequences of nuclear ribosomal internal transcribed spacer 1. | we performed a cluster analysis of human and animal pathogenic microsporum species and their teleomorphic states, arthroderma species, including a. otae-related species (m. canis, m. audouinii, m. distortum, m. equinum, m. langeronii, and m. ferrugineum) and m. gypseum complex (a. fulvum, a. gypseum, and a. incurvatum) using dna sequences of nuclear ribosomal internal transcribed spacer 1 (its1). the dendrogram showed the members of a. otae-related species to be monophyletic and to construct an ... | 2001 | 11345530 |
| etiology of dermatophytoses amongst children in northeastern nigeria. | a survey of dermatophytoses was carried out amongst primary school children in borno state, nigeria, during february 1997 to january 1998. a total of 2,193 children aged 4-16 years were screened. out of these, 154 (7.0%) were proved to be mycologically positive by microscopy, culture or both. incidence was significantly higher (p <0.05) in young children aged 7-11 years (8.1%) and 4-6 years (6.9%) than in older children aged 12-16 years (3.6%). there was a significant difference in the incidence ... | 2001 | 11346266 |
| a specific pcr assay for the dermatophyte fungus microsporum canis. | a dna fragment of approximately 1.2 kb, generated from the common dermatophyte microsporum canis by arbitrarily primed polymerase chain reaction (pcr) using random primer opu13, was cloned and sequenced. based on the resulting sequencing data, a forward primer (mc1f) and a reverse primer (mc1r) have been designed and assessed by pcr for their usefulness in the improved identification of m. canis. the results obtained suggest that these primers are specific for m. canis, as a band of 900 bp was a ... | 2001 | 11346271 |
| a case of feline otitis externa due to microsporum canis. | we describe a case of a 3-month-old persian male cat with a persistent waxy, ceruminous, otic discharge in both external auditory canals. after microbiological culture, only microsporum canis was isolated with no concurrent fungal or bacterial flora. fungal otitis due to dermatophytes was diagnosed and specific treatment with griseofulvin was administered. after 4 weeks of treatment, no m. canis colonies were isolated and clinical recovery had occurred. in view of this case, dermatophytosis shou ... | 2001 | 11346273 |
| intra-abdominal dermatophytic pseudomycetoma in a persian cat. | 2001 | 11380034 | |
| tinea capitis. | 2001 | 11398258 | |
| the aetiological agents of tinea capitis in zaragoza (spain). | between 1977 and 1997, 190 cases of tinea capitis were observed. the age groups most commonly infected were 1-10 years old. the following dermatophytes were isolated: microsporum canis (119), trichophyton mentagrophytes (57), trichophyton tonsurans (seven), trichophyton verrucosum (three), trichophyton violaceum (one), trichophyton schoenleinii (one), trichophyton soudanense (one) and microsporum audouinii (one). | 2001 | 11398641 |
| exocellular enzyme activity of dermatophytes and other fungi isolated from ruminants in southern iraq. | sixteen fungal species were isolated from 182 specimens collected from four ruminants (buffalo, camel, cattle and sheep) in southern iraq. fungi represented by five species of dermatophytes and eleven species of other fungi were screened for the activity of four enzymes: keratinase. proteinase, lipase and amylase. keratinase was found to be produced by all of the dermatophytes and non-dermatophytes, except for paecillomyces variottii and scytalidium lignicola. however, high keratinase activity w ... | 2001 | 11407490 |
| antifungal activity of modified hederagenin glycosides from the leaves of kalopanax pictum var. chinense. | monodesmosides which were obtained from the partial degradation of hederagenin bisdesmosides exhibited significant antifungal effect against microsporum canis, coccidioides immitis, trichophyton mentagrophytes, cryptococcus neoformans, and candida albicans at the minimal inhibitory concentrations of 6.25-25 microg/ml. the hederagenin glycosides were isolated from the leaves of kalopanax pictum var. chinense. | 2001 | 11411568 |
| oral terbinafine for tinea capitis due to microsporum canis in children. | 2001 | 11411922 | |
| antifungal activities of pelargonic and capric acid on microsporum gypseum. | the inhibitory effects of pelargonic and capric acid on microsporum gypseum were examined. solid and liquid sabouraud glucose media containing different concentrations of pelargonic and capric acid were separately prepared and inoculated with the suspension of mycelium and spores of m. gypseum and incubated at 25 degrees c for 1 month. the culture media were examined periodically for fungal growth and the minimum inhibitory concentration (mic) of each fatty acid was determined. the mic for capri ... | 2001 | 11413921 |
| case report. onychomycosis due to microsporum canis. | a case of distal subungual onychomycosis of the big toe due to microsporum canis is reported in a 69-year-old male asthma patient who had been treated with systemic corticosteroids for the last 3 years. the nail infection was contracted from a cat who was a healthy carrier. the patient was treated successfully with intermittent itraconazole therapy. | 2001 | 11413924 |
| effectiveness of terbinafine in the eradication of microsporum canis from laboratory cats. | in this study, the coats of 20 cats with no dermatophytosis lesions were sampled for colonization by microsporum canis, which was isolated in 45% of cases. all cats were treated with oral terbinafine for 3 weeks. the drug was administered orally at a daily dosage 8.25 mg kg-1. mycologic status was assessed at the end of the treatment; and after follow-up at 2 days, and 4 and 9 weeks. the final evaluation revealed a complete mycologic cure of all cats by obtaining negative cultures, thereby demon ... | 2001 | 11413930 |
| evaluation of the dermatophyte test medium rapidvet-d. | the performance of the dermatophyte test medium (dtm) rapidvet-d was assessed using hair samples collected from experimentally infected guinea pigs. three dermatophyte species were included in the study: microsporum canis, trichophyton mentagrophytes and trichophyton equinum. dtm substrates were inoculated with infected hairs and scales, incubated at 18, 21, 24, 27 or 37 degrees c and examined daily for 15 days. the rapidity of colour change was clearly related to the incubation temperature and ... | 2001 | 11420927 |
| unusual manifestations of dermatophytoses. | 2001 | 11422516 | |
| purification and characterization of a 43.5 kda keratinolytic metalloprotease from microsporum canis. | a keratinolytic protease secreted by a feline clinical isolate of microsporum canis cultivated in a broth containing feline keratin as the sole nitrogen source was purified from the culture filtrate by affinity chromatography on bacitracin-agarose and by hydrophobic chromatography on octyl-agarose. the enzyme had an apparent molecular mass of 43.5 kda and the pi was 7.7. it had a significant activity against keratin azure, elastin-congo red and denatured type i collagen (azocoll). using the latt ... | 2001 | 11446530 |
| hair and scalp mycobiota in school children in nablus area. | hair and scalp mycobiota of 1389 clinically normal children aged 6-12 years attending 12 schools in the nablus district, palestinian authority, was assessed on three occasions over 8-month period (october 1998-may 1999) using the hair brush technique. one hundred and one fungal species belonging to 33 genera were recovered: 6 dermatophytes, 16 dermatophyte-like keratinophilic fungi, and 79 other keratinophilic fungal species. species varied considerably in their frequency of occurrence and abund ... | 2001 | 11469760 |
| antimicrobial activity of alstonia macrophylla: a folklore of bay islands. | the methanolic crude and methanol-aqueous extract of alstonia macrophylla leaves and n-butanol part of the crude extract showed antimicrobial activity against various strains of staphylococcus aureus, staphylococcus saprophyticus, streptococcus faecalis, escherichia coli, proteus mirabilis, trichophyton rubrum, trichophyton mentagrophytes var. mentagrophytes and microsporum gypseum. the minimum inhibitory concentration (mic) values ranges from 64 to 1000 microg/ml for bacteria and 32-128 mg/ml f ... | 2001 | 11483378 |
| purification of diacylglycerol kinase from microsporum gypseum and its phosphorylation by the catalytic subunit of protein kinase a. | diacylglycerol (dg) kinase (ec 2.7.1.107) was purified to homogeneity from the soluble extract of microsporum gypseum, a dermatophyte. purified enzyme showed a final specific activity of 2172 pmol/min/mg protein and its apparent molecular weight on sds-page was found to be 93 kda. the activity of purified enzyme was inhibited in a dose-dependent manner in the presence of dg-kinase inhibitor (d5919, sigma). dg-kinase activity was found to be stimulated in the presence of phosphatidylcholine, phos ... | 2001 | 11488595 |
| two cases of dermatophytic pseudomycetoma in the dog: an immunohistochemical study. | two cases of canine dermatophytic pseudomycetoma resulting in subcutaneous nodules resembling those previously reported in persian cats are described. culture performed from one nodule yielded dark yellow colonies consistent with microsporum canis. immunohistochemistry, using rabbit anti-m. canis, demonstrated specific binding to fungal elements in paraffin sections. the specificity of the antiserum was further tested by an agar gel immunodiffusion assay using a soluble extract from a feline iso ... | 2001 | 11493404 |
| in vitro and in vivo activities of syn2836, syn2869, syn2903, and syn2921: new series of triazole antifungal agents. | the in vitro and in vivo activities of four azole compounds belonging to a new series of 2(2,4-difluorophenyl)-3-(4-substituted piperazin-1-yl)-1-(1,2,4-triazol-1-yl) butanol antifungal agents is described. the compounds were selected from a library of azole compounds synthesized by our group. the in vitro activities of syn2869, syn2836, syn2903, and syn2921 against a panel of over 240 recently collected clinical isolates of yeast and molds were determined, and the results were compared with tho ... | 2001 | 11502508 |
| expression of ubiquitin gene in microsporum canis and trichophyton mentagrophytes cultured with fluconazole. | the expression of the ubiquitin (ub) gene in dermatophytes was examined for its relation to resistance against the antifungal drug fluconazole. the nucleotide sequences and the deduced amino acid sequences of the ub gene in microsporum canis were proven to be 99% similar to those of the ub gene in trichophyton mentagrophytes. expression of mrna of ub in m. canis and t. mentagrophytes was enhanced when the fungi were cultured with fluconazole. the antifungal activity of fluconazole against these ... | 2001 | 11502529 |
| application of pcr to distinguish common species of dermatophytes. | this report describes the application of pcr fingerprinting for the identification of species and varieties of common dermatophytes and related fungi utilizing as a single primer the simple repetitive oligonucleotide (gaca)(4). the primer was able to amplify all the strains, producing species-specific profiles for microsporum canis, microsporum gypseum, trichophyton rubrum, trichophyton ajelloi, and epidermophyton floccosum. intraspecific variability was not observed for these species. instead, ... | 2001 | 11526185 |
| cutaneous xanthomas with concurrent demodicosis and dermatophytosis in a cat. | multiple cutaneous xanthomas, associated with fasting hyperlipidaemia, are described in a 9-month-old domestic long-haired cat. a severely pruritic, papular, and crusting dermatitis affecting the head and neck, initially diagnosed as lesions of the eosinophilic granuloma complex, progressively developed on the head and pinnae. pruritus was controlled with administration of prednisolone and chlorambucil. repeat histological examination confirmed the diagnosis of cutaneous xanthoma and concurrent ... | 2001 | 11549045 |
| dermatophytes and other fungi associated with skin mycoses in tripoli, libya. | our objective in this study was to obtain information on the prevalence of fungi responsible for superficial mycoses in the region of tripoli, libya. | 2001 | 17264550 |
| [urban and rural mycozoonoses]. | the main mycozoonoses are due to specific dermatophytes which are pathogens for man and animals. contamination occurs most often after close contact with the animal showing clinical lesions or with inapparent carriage only. the contaminated environment also participates to the mycozoonotic epidemics. interhuman transmission is more rarely encountered. young children before puberty are most receptive to the disease. the main urban mycozoonosis is due to microsporum canis transmitted by dogs and c ... | 2000 | 11195712 |
| epidemiology of tinea capitis. | this paper addresses the changing epidemiology of tinea capitis in the usa and in europe that has occurred over the last several decades. several dermatophytes are involved in the etiology, and the primary etiological agents of tinea capitis are limited to the genera microsporum and trichophyton. in addition, the sources of these infections are discussed and although geophilic dermatophytes occur worldwide, anthropophilic species and some zoophilic fungi may be geographically restricted, dependi ... | 2000 | 11204144 |
| natural pathogens of laboratory animals and their effects on research. | the natural fungal pathogens of laboratory animals such as rabbits and guinea pigs are mainly dermatophyte species, most commonly trichophyton mentagrophytes and also, less frequently microsporum gypseum and m. canis. however, the incidences of infection and clinical disease are low in well-managed animal facilities. young or immunocompromised rabbits are thought to be most susceptible. dermatophytes infect the epidermis and adnexal structures, including hair follicles and shafts, usually on or ... | 2000 | 11204165 |
| zoophilic and geophilic dermatophytoses among farmers and non-farmers in eastern poland. | the study was aimed at assessing the frequency of zoophilic and geophilic fungal infections among farmers compared to non-farmers in eastern poland. the study was carried out on adult patients with a suspicion of fungal infection of skin or its appendages. skin scrapings or nail fragments were cultured on sabouraud agar with chloramphenicol and cycloheximide for at least 3 weeks, and then identified based on macroscopic and microscopic morphology. in total, 116 subjects were included into the fa ... | 2000 | 11153042 |
| tinea faciei due to microsporum canis abscess formation. | superficial dermatophyte infections are common in children; however, complications are encountered rarely. we describe a child with tinea faciei caused by microsporum canis, who subsequently developed an abscess. complete resolution occurred after treatment with oral terbinafine. | 2000 | 11167972 |
| tinea faciei in a newborn: a new case. | 2000 | 11123794 | |
| keratinopathogenic mould fungi and dermatophytes in healthy and diseased hooves of horses. | specimens of hoof horn from 187 horses were examined for a possible relationship between clinically affected hooves and the occurrence of pathogenic fungi. specimens were taken from the coronary band and from the stratum externum and medium of the coronary horn and transferred on to sabouraud dextrose agar, with and without cycloheximide, and incubated at 28 degrees c. dermatophytes and mould fungi were identified by their macroscopic and microscopic characteristics. the 732 isolates could be as ... | 2000 | 11128074 |
| fungal flora on cutaneous and mucosal surfaces of cats infected with feline immunodeficiency virus or feline leukemia virus. | to compare cutaneous and mucosal mycoflora in cats infected with fiv or felv with that in noninfected cats. | 2000 | 10685687 |
| purification and characterization of camp dependent protein kinase from microsporum gypseum. | a cyclic amp dependent protein kinase (pka), its regulatory (r) and catalytic (c) subunits were purified to homogeneity from soluble extract of microsporum gypseum. purified enzyme showed a final specific activity of 277.9 nmol phosphate transferred min(-1) mg protein(-1) with kemptide as substrate. the enzyme preparation showed two bands with molecular masses of 76 kda and 45 kda on sodium dodecyl polyacrylamide gel electrophoresis. the 76 kda subunit was found to be the regulatory (r) subunit ... | 2000 | 10699496 |
| tinea incognito due to microsporum gypseum in three children. | tinea incognito is a dermatophytosis of atypical clinical character due to the absence of classic features of ringworm. it is caused by prolonged use of topical steroids, sometimes prescribed as a result of incorrect diagnosis. the cases reported in the literature have different clinical presentations and have generally been in adults. we report three children with tinea incognito in whom the lesions were psoriasis-like, eczema-like, and lichenoid, respectively. diagnosis was confirmed by mycolo ... | 2000 | 10720987 |
| once weekly fluconazole is effective in children in the treatment of tinea capitis: a prospective, multicentre study. | in an open, multicentre evaluation carried out in brazil, canada and south africa we have demonstrated that fluconazole 8 mg kg-1 once weekly is effective in tinea capitis caused by trichophyton and microsporum species. there were 61 children, aged (mean +/- se) 5.0 +/- 0.3 years; weight (mean +/- 5.6) 20.0 +/- 0.9 kg; 41 males, 20 females; one asian, 57 black, one caucasian and two hispanic. the organisms were trichophyton violaceum (33 patients), t. tonsurans (11) and microsporum canis (17). t ... | 2000 | 10809856 |
| tinea capitis in benghazi, libya. | tinea capitis is a worldwide problem. it affects mainly school age children. late detection and improper treatment of the inflammatory type of this disease may result in disfigurement and permanent alopecia. the objectives of this study were to determine the prevalence, clinical types, and causative species of tinea capitis in benghazi, libya. | 2000 | 10809973 |
| molecular and conventional taxonomy of the microsporum canis complex. | the validity of taxa around microsporum canis was evaluated by a combination of phenetic and molecular methods. morphological and physiological features were compared with results of sequencing of the internal transcribed spacer (its) region of the ribosomal operon, polymerase chain reaction (pcr) fingerprinting and amplified fragment length polymorphism (aflp) analysis. the seven species investigated seem to be infraspecific taxa and were reclassified or synonymized as m. canis (teleomorph: art ... | 2000 | 10817231 |
| an evaluation of the in vitro activity of terbinafine. | terbinafine has previously been shown to be highly active against dermatophytes and many other filamentous fungi. however, its activity against yeasts is controversial, with earlier reports suggesting that it has low activity, while more recent studies demonstrated that terbinafine is effective against yeasts. in this study, the in vitro activity of terbinafine was evaluated against a broad range of fungal isolates. we examined the susceptibility of 100 yeast strains (10 species including candid ... | 2000 | 10817232 |
| inhibitors of the fungal cell wall. synthesis of 4-aryl-4-n-arylamine-1-butenes and related compounds with inhibitory activities on beta(1-3) glucan and chitin synthases. | as part of our project devoted to the search for antifungal agents, which act via a selective mode of action, we synthesized a series of new 4-aryl- or 4-alkyl-n-arylamine-1-butenes and transformed some of them into 2-substituted 4-methyl-tetrahydroquinolines and quinolines by using a novel three-step synthesis. results obtained in agar dilution assays have shown that 4-aryl homoallylamines not possessing halogen in their structures, tetrahydroquinolines and quinolines, display a range of antifu ... | 2000 | 10819157 |
| efficacy of chlorhexidine against some strains of cultured and clinically isolated microorganisms. | the efficacy of chlorhexidine digluconate was determined against some strains of collected and clinically isolated bacteria and fungi. the efficacy was evaluated either by calculating a minimum inhibitory concentration (mic) or by efficacy trials according to the guidelines of the european committee for standardization. the mic values of chlorhexidine for staphylococcus aureus, microsporum gypseum, microsporum canis and trichophyton mentagrophytes were 0.625 microg/ml, 12.5 microg/ml, 50 microg/ ... | 2000 | 10836268 |
| case reports. pityriasis amiantacea as manifestation of tinea capitis due to microsporum canis. | we report three patients, two infants and an adult, in whom their tinea capitis clinically appeared as pityriasis amiantacea. the mycological studies showed infection due to microsporum canis in all cases. correct diagnosis as well as adequate antimycotic chemotherapy of this atypical manifestation of tinea capitis remain a challenge to the clinician. epidemiological aspects must be regarded also. | 2000 | 10838857 |