Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| experimental lassa virus infection in the squirrel monkey. | experimental lassa virus infection was investigated in a nonhuman primate in order to elucidate the target organs of the viral infection and the course of pathologic events. four squirrel monkeys (saimiri scirreus) were inoculated intramuscularly with lassa virus and sacrificed for organ titrations and histopathology, one each day, on days 7, 12, 14, and 28 after inoculation. the animals showed a variable clinical course, with an incubation period of 8 to 18 days. the virus was demonstrated to b ... | 1975 | 1163630 |
| lassa virus hepatitis. observations on a fatal case from the 1972 sierra leone epidemic. | during a recent outbreak of lassa fever in sierre leone, a 20-year-old woman developed an acute febrile disease with tonsillar exudates and hemorrhagic manifestations. lassa virus was isolated in cell cultures from pharyngeal secretions and pleural fluid and was identified by complement fixation. typical arenavirus particles were observed in these infected cell cultures. in a liver biopsy specimen, diffuse hepatocellular damage and focal necroses were evident, with a spectrum of liver cell chang ... | 1975 | 1227472 |
| lassa fever. | 1975 | 1040192 | |
| handling patients with suspected lassa fever entering great britain. | a special isolation unit has been created at the hospital for tropical diseases, london, for the reception of patients arriving in great britain from west africa with suspected lassa fever. the management of such patients and the operation of the unit are described. experience during the first eighteen months of operation has been very satisfactory and valuable lessons have been learned concerning the diagnosis and treatment of lassa fever and the nursing of patients. | 1975 | 1085226 |
| surveillance of lassa fever in missionaries stationed in west africa. | to determine the distribution of lassa virus in west africa, a serological survey was undertaken. a number of mission hospital supplied sera from patients admitted with a history of fever and specimens were also collected in new york from missionaries who had experienced an unusual febrile illness while working in africa. more cases of lassa fever were detected among missionaries than among africans, possibly because many african patients had left hospital before the complement fixation tests ha ... | 1975 | 1085213 |
| lassa fever in onitsha, east central state, nigeria in 1974. | three cases of lassa fever occurred in onitsha, east central state, nigeria, in january and february 1974. the first case was a 19-year-old nigerian; the other 2 cases were german missionary physicians at st charles borromeo hospital, onitsha, one of whom cared for the patient who was the first case. thus, 2 of the 3 cases were hospital acquired. investigations failed to discover a village outbreak or the source of virus for the first case. a serosurvey of 258 hospital staff members and contacts ... | 1975 | 1085214 |
| use of the complement fixation (cf) test in lassa fever surveillance. evidence for persistent cf antibodies. | a survey to detect individuals with antibodies to lassa virus was undertaken among hospital personnel in the eastern and southern provinces of sierra leone late in 1974. sera were evaluated by the complement fixation test. the data obtained showed that some contacts of lassa fever patients in the 1972 epidemic had developed antibodies to the virus; individuals who had never reported being sick also showed evidence of infection, with significant cf antibody titres in their sera. surviving lassa f ... | 1975 | 1085215 |
| editorial: lassa or marburg or jo'burg. | 1975 | 47490 | |
| letter: lassa by letter. | 1975 | 52067 | |
| morphology and morphogenesis of arenaviruses. | arenaviruses have unique structural characteristics; they are pleomorphic, have a mean diameter of 110-130 nm, and consist of a membranous envelope with surface projections surrounding an interior containing ribosomes and filaments. virus particles bud from plasma membranes of infected cells and in many cases large intracytoplasmic inclusion bodies are formed. these characteristics allow generic identification, but not differentiation of individual viruses. ultrastructural identification of viru ... | 1975 | 182396 |
| arenavirus taxonomy: a review. | despite a late beginning, the construction of the arenavirus taxon and its placement in the scheme of the international committee on taxonomy of viruses has now been completed. the bringing together of the member viruses has already provided valuable indications of promising laboratory and field study approaches; in the future this classification will contribute further to our understanding of the natural history and disease processes of the human pathogens of the group. | 1975 | 182395 |
| arenaviruses. | 1975 | 168692 | |
| [viral contamination in laboratories and hospital units]. | viral contamination is at least as important in hospital laboratories and wards as contamination by bacteria or microscopic fungi, but it is much more insidious and sometimes unrecognized. there are two main types: the first has a purely technical effect and only interest the virologist. this is contamination of reagents, reference strains, cell cultures, etc.., by foreign viral agents. it may be the cause of errors on diagnosis or regrettable errors of interpretation of certain experimental dat ... | 1975 | 165448 |
| editorial: lassa fever. | 1975 | 46518 | |
| status of arenavirus vaccines and their application. | a limited but definite need exists for vaccines against lassa, junin, and machupo viruses. medical and laboratory personnel, as well as defined high-risk population groups, require protection from these highly virulent agents. to date little work has been done on inactivated vaccines for these viruses. a live attenuated junin vaccine has been tested successfully in more than 600 persons, and a high-passage machupo virus strain has protected rhesus monkeys against lethal infection produced by a h ... | 1975 | 182407 |
| antigenic properties of the arenaviruses. | arenaviruses are known to show antigenic relationships in the complement-fixation (cf) and fluorescent antibody tests but not in the neutralization test. the humoral response to some of the arenaviruses is characterized by a dissociation between the antibodies determined by the cf test and those determined by the neutralization test and also by its late appearance following natural infection. investigations are reported showing that, as regards the cf test, junin, machupo, amapari, and tacaribe ... | 1975 | 182397 |
| lassa fever: review of epidemiology and epizootiology. | the basic ecology of lassa fever appears to involve enzootic transmission of virus in commensal populations of a single murine species, mastomys natalensis. virus may spill over from the rodent cycle to man by various routes. secondary spread between humans may occur within domiciliary groups, and persons infected within the community who develop clinical disease may introduce the virus into hospital and begin a cycle of nosocomial infection.between 1969, when lassa fever was first described, an ... | 1975 | 782738 |
| editorial: viral haemorrhagic fevers. | 1975 | 810212 | |
| lassa virus infection in mastomys natalensis in sierra leone. gross and microscopic findings in infected and uninfected animals. | pathological examinations of 28 wild-caught mastomys natalensis from sierra leone, 14 of which were positive for lassa virus by tissue culture, are reported. the high frequency of neoplastic and degenerative diseases observed among older animals in closed colonies of m. natalensis were not observed in the wild animals studied. this is probably a reflection of the age distribution of the study population, since the life expectancy of wild mastomys is less than a year. inflammatory lesions were no ... | 1975 | 1085221 |
| [viral hemorrhagic fever in man]. | 1975 | 1103342 | |
| editorial: lassa and marburg viruses. | 1975 | 810647 | |
| indirect immunofluorescence for the diagnosis of lassa fever infection. | the indirect immunofluorescent technique is a rapid method for identification of lassa virus and lassa virus antibody. in the study reported here, lassa virus antigen was detected by this method in vero cell cultures within 24 hours of their inoculation with an infected human blood specimen. a diagnosis could be made from field-collected specimens within 3 days of their receipt.fluorescent antibodies against lassa virus were detected in human serum as early as 7 to 10 days after onset of illness ... | 1975 | 821624 |
| comparative pathology of lassa virus infection in monkeys, guinea-pigs, and mastomys natalensis. | experimental lassa virus infections of squirrel monkeys, guinea-pigs, and the african multimammate rat, mastomys natalensis, were studied virologically and pathologically. in the monkeys, early viral lymphoreticulotropism, hepatotropism, nephrotropism, and viraemia were noted. at the time of death, viral titres in nearly all target organs were associated with necrotic changes: splenic lymphoid necrosis, renal tubular necrosis, myocarditis, arteritis, and hepatocytic regeneration. in convalescent ... | 1975 | 821625 |
| lassa fever and marburg virus disease. | 1974 | 4208764 | |
| lassa fever. | 1974 | 4213599 | |
| hoosiers abroad--report of a case of lassa fever. | 1974 | 4604539 | |
| lassa virus isolation from mastomys natalensis rodents during an epidemic in sierra leone. | lassa fever is a severe febrile illness of man, first recognized in west africa in 1969. during an epidemic in sierra leone, lassa virus was isolated for the first time from wild rodents of mastomys natalensis. a high prevalence of infected mastomys was found in houses occupied by patients with lassa fever. the data presented provide the first demonstration of an extra-human cycle of lassa virus transmission and suggest that rodent control may be an effective method of limiting the disease. | 1974 | 4833828 |
| biochemical and biophysical properties of the arenaviruses. | 1974 | 4608220 | |
| lassa fever in the eastern province of sierra leone, 1970-1972. i. epidemiologic studies. | 1974 | 4429182 | |
| lassa fever in the eastern province of sierra leone, 1970-1972. ii. clinical observations and virological studies on selected hospital cases. | 1974 | 4429183 | |
| [lassa-fever a new dangerous virus infection]. | 1974 | 4453164 | |
| [lassa fever]. | 1974 | 4424106 | |
| [lassa fever (author's transl)]. | 1974 | 4431978 | |
| undiagnosed fever--rickettsial, viral, and helminth infections. | 1974 | 4479614 | |
| tropical pathology. | 1974 | 4619032 | |
| [transport of a patient with lassa fever in a boeing 707 b]. | 1974 | 4281903 | |
| [lassa virus disease]. | 1974 | 4407885 | |
| editorial: rodent control and lassa fever. | 1974 | 4137628 | |
| lassa fever. | 1973 | 4745120 | |
| lassa fever in britain: an imported case. | 1973 | 4755184 | |
| virus diseases associated with cutaneous eruptions. | 1973 | 4356897 | |
| a hospital epidemic of lassa fever in zorzor, liberia, march-april 1972. | 1973 | 4745236 | |
| clinical presentation of lassa fever cases during the hospital epidemic at zorzor, liberia, march-april 1972. | 1973 | 4745237 | |
| [lassa fever (review of the literature)]. | 1973 | 4594659 | |
| editorial: tropical viral infections. | 1973 | 4745118 | |
| [african zoonoses caused by viruses]. | 1973 | 4346544 | |
| lassa fever. | 1972 | 5083882 | |
| [histopathological diagnosis of hepatitis due to lassa virus]. | 1972 | 4679205 | |
| lassa fever, a new virus disease of man from west africa. iv. electron microscopy of vero cell cultures infected with lassa virus. | 1970 | 4987548 | |
| isolation and antigenic characterization of lassa virus. | 1970 | 5428406 | |
| [the tragic story of the discovery of the lassa fever virus]. | 1970 | 5498893 | |
| [lassa virus]. | 1970 | 4991418 | |
| undiagnosed acute viral febrile illnesses, sierra leone. | sierra leone in west africa is in a lassa fever-hyperendemic region that also includes guinea and liberia. each year, suspected lassa fever cases result in submission of ≈500-700 samples to the kenema government hospital lassa diagnostic laboratory in eastern sierra leone. generally only 30%-40% of samples tested are positive for lassa virus (lasv) antigen and/or lasv-specific igm; thus, 60%-70% of these patients have acute diseases of unknown origin. to investigate what other arthropod-borne an ... | 0 | 24959946 |
| a bsl-4 high-throughput screen identifies sulfonamide inhibitors of nipah virus. | nipah virus is a biosafety level 4 (bsl-4) pathogen that causes severe respiratory illness and encephalitis in humans. to identify novel small molecules that target nipah virus replication as potential therapeutics, southern research institute and galveston national laboratory jointly developed an automated high-throughput screening platform that is capable of testing 10,000 compounds per day within bsl-4 biocontainment. using this platform, we screened a 10,080-compound library using a cell-bas ... | 0 | 24735442 |
| the search for animal models for lassa fever vaccine development. | lassa virus (lasv) is the most prevalent arenavirus in west africa and is responsible for several hundred thousand infections and thousands of deaths annually. the sizeable disease burden, numerous imported cases of lassa fever (lf) and the possibility that lasv can be used as an agent of biological warfare make a strong case for vaccine development. currently there is no licensed lf vaccine and research and devlopment is hampered by the high cost of nonhuman primate animal models and by biocont ... | 0 | 23256740 |
| genomic profiling of host responses to lassa virus: therapeutic potential from primate to man. | lassa virus infection elicits distinctive changes in host gene expression and metabolism. we focus on changes in host gene expression that may be biomarkers that discriminate individual pathogens or may help to provide a prognosis for disease. in addition to assessing mrna changes, functional studies are also needed to discriminate causes of disease from mechanisms of host resistance. host responses that drive pathogenesis are likely to be targets for prevention or therapy. host responses to las ... | 0 | 25844088 |
| vectorborne infections, mali. | 0 | 26812625 |