Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| endocrine-mediated effects of 4,4'-(hexafluoroisopropylidene)diphenol in sd rats, based on a subacute oral toxicity study. | the purpose of this study was to investigate the endocrine-mediated effects of 4,4'-(hexafluoroisopropylidene)diphenol according to oecd test guideline no. 407. the estrogenic properties of this chemical have already been shown on uterotrophic assay, and this chemical is classified as a low-production volume chemical in reach program. rats were orally gavaged with 0, 10, 30, and 100-ámg/kg/day of test chemical for at least 28-ádays, beginning at 8-áweeks of age. in the 100-ámg/kg group of male r ... | 2011 | 21713527 |
| re: aggressive surgical approach for patients with t4 gastric carcinoma: promise or myth? | 2011 | 21725684 | |
| highly sensitive chemiluminescent point mutation detection by circular strand-displacement amplification reaction. | single nucleotide polymorphism (snp) genotyping is attracting extensive attentions owing to its direct connections with human diseases including cancers. here, we have developed a highly sensitive chemiluminescence biosensor based on circular strand-displacement amplification and the separation by magnetic beads reducing the background signal for point mutation detection at room temperature. this method took advantage of both the t4 dna ligase recognizing single-base mismatch with high selectivi ... | 2011 | 21684734 |
| radiochemotherapy versus surgery plus radio(chemo)therapy for stage t3/t4 larynx and hypopharynx cancer - results of a matched-pair analysis. | the standard treatment for non-metastatic t3/t4 larynx and hypopharynx cancer varies. this study compared definitive radiochemotherapy to surgery followed by radio(chemo)therapy. forty-four patients treated with radiochemotherapy were matched to 88 patients receiving surgery plus radio(chemo)therapy. groups were matched 1:2 for eight factors including age, gender, performance status, tumour site, histologic grade, t-/n-category and ajcc stage. groups were compared for loco-regional control, meta ... | 2011 | 21726998 |
| t4 rna ligase 2 truncated active site mutants: improved tools for rna analysis. | abstract: | 2011 | 21722378 |
| effects of uranium uptake on transcriptional responses, histological structures and survival rate of the crayfish procambarus clarkii. | this work aims to investigate the accumulation levels and effects (transcriptional responses, histopathology and survival rate) associated with a wide range of dissolved uranium (u) concentrations (0, 0.03, 0.6, 4 and 8mg/l of u) on adult male crayfish procambarus clarkii during 4 (t4) and 10 (t10) days of exposure. the follow-up of the crayfish mortality showed that p. clarkii was highly resistant to u. increasing waterborne u concentrations led to increasing bioaccumulation in key crayfish org ... | 2011 | 21741087 |
| phase ii trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (t4) pancreatic adenocarcinoma: correlation of smad4(dpc4) immunostaining with pattern of disease progression. | this phase ii trial was designed to assess the efficacy and safety of cetuximab, gemcitabine, and oxaliplatin followed by cetuximab, capecitabine, and radiation therapy in locally advanced pancreatic cancer (lapc). | 2011 | 21709185 |
| effects of supplementing erythrina brucei leaf as a substitute for cotton seed meal on growth performance and carcass characteristics of sidama goats fed basal diet of natural grass hay. | the replacement value of dried erythrina brucei leaf for cotton seed meal (csm) on growth performance and carcass characteristics was evaluated. twenty-five yearling buck goats (15.8ôçë-¦ôçë1.4-ákg) were assigned into five treatments in a randomized complete block design: natural grass hay alone (t1) or supplemented with 100% csm (t2), 67% csmôçë+ôçë33% e. brucei (t3), 33% csmôçë+ôçë67% e. brucei (t4), and 100% e. brucei (t5) on dry matter (dm) basis. supplemented goats consumed more (pôçë<ôçë0. ... | 2011 | 21735342 |
| simple and efficient synthesis of 5' pre-adenylated dna using thermostable rna ligase. | we report a simple method of enzymatic synthesis of pre-adenylated dna linkers/adapters for next-generation sequencing using thermostable rna ligase from methanobacterium thermoautotrophicum (mthrnl). using rna ligase for the reaction instead of the existing chemical or t4 dna ligase-based methods allows quantitative conversion of 5'-phosphorylated single-stranded dna (ssdna) to the adenylated form. the mthrnl adenylation reaction is specific for atp and either ssdna or rna. in the presence of m ... | 2011 | 21724605 |
| evaluation of resistance development and viability recovery by a non-enveloped virus after repeated cycles of apdt. | nowadays, the emergence of drug resistant microorganisms is a public health concern. the antimicrobial photodynamic therapy (apdt) has an efficient action against a wide range of microorganisms and can be viewed as an alternative approach for treating microbial infections. the aim of this study was to determine if a model target virus (t4-like bacteriophage), in the presence of the tricationic porphyrin 5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin tri-iodide (tri-py(+)-m ... | 2011 | 21722673 |
| functional imaging of larynx via 256-slice multi-detector computed tomography in patients with laryngeal tumors: a faster, better and more reliable pre-therapeutic evaluation. | objective: to determine the clinical utility of using dynamic maneuvers during imaging of larynx via 256-slice multi-detector computed tomography in the pre-therapeutic evaluation of laryngeal tumors. materials and methods: a total of 27 patients (7 women, 20 men; aged 53-76 years) diagnosed with laryngeal squamous cell carcinoma were evaluated pre-therapeutically via contrast enhanced axial ct scans during consecutive phases of phonation (pp), inspiration (ip) and valsalva maneuver (vp). result ... | 2011 | 21724356 |
| the effectiveness of a walking booster program for seniors. | to determine the effectiveness of a 3-month home-based booster program for seniors to increase walking. | 2011 | 21721960 |
| elements of oxidation/reduction balance in experimental hypothyroidism. | the aim of this study was to investigate the effect of the decreased level of thyroid hormones on selected parameters of the oxidation/reduction balance by assessing the activity of antioxidant enzymes: superoxide dismutase (sod), and glutathione peroxidase (gsh-px); the level of antioxidant vitamins (a, c, and e); and the concentration of compounds reacting with thiobarbituric acid (tbars). | 2011 | 21717403 |
| comparison of methimazole and propylthiouracil in the management of children and adolescents with graves' disease: efficacy and adverse reactions during initial treatment and long-term outcome. | the aim of this study was to compare the efficacy and adverse reactions during initial treatment and long-term outcome between children and adolescents with graves' disease (gd) treated with propylthiouracil (ptu) and those treated with methimazole (mmi). | 2011 | 21823520 |
| functional evaluation of bacteriophage t4 rad50 signature motif residues. | the repair of dna double-strand breaks (dsbs) is essential to maintaining the integrity of the genome, and organisms have evolved a conserved mechanism to facilitate their repair. in eukaryotes, archaea, and some bacteriophage, a complex made up of mre11 and rad50 (mr complex), which are a nuclease and atpase, respectively, is involved in the initial processing of dsbs. rad50 is a member of the atp binding cassette (abc) protein superfamily, the members of which contain an important signature mo ... | 2011 | 21675703 |
| a comparison of spinal isobaric levobupivacaine and racemic bupivacaine for lower abdominal and lower extremity surgery. | levobupivacaine is a new long-acting local anesthetic, which is the isolated s-enantiomer of racemic bupivacaine with less cardiovascular and central nervous system toxicity than bupivacaine. reports using levobupivacaine for epidural or brachial plexus anesthesia suggested equivalent clinical efficacy to bupivacaine. however, inadequate information for spinal anesthesia was found | 2011 | 21696081 |
| using free energy of binding calculations to improve the accuracy of virtual screening predictions. | virtual screening of small molecule databases against macromolecular targets was used to identify binding ligands and predict their lowest energy bound conformation (i.e., pose). autodock4-generated poses were rescored using mean-field pathway decoupling free energy of binding calculations and evaluated if these calculations improved virtual screening discrimination between bound and nonbound ligands. two small molecule databases were used to evaluate the effectiveness of the rescoring algorithm ... | 2011 | 21696204 |
| treatment of t4 esophageal cancer. definitive chemo-radiotherapy vs chemo-radiotherapy followed by surgery. | the outcome of patients with t4 esophageal cancer, defined as a tumor that invades neighboring structures (e.g., aorta, trachea, bronchus, and lung), is extremely poor. despite recent advances in surgical techniques, these tumors are usually considered inoperable. two distinct therapeutic options are currently available for t4 esophageal cancers: chemo-radiotherapy followed by surgery (crt-s), which comprises esophagectomy following down-staging of the tumor by crt, and definitive chemo-radiothe ... | 2011 | 21697781 |
| transcriptional regulation by nonclassical action of thyroid hormone. | abstract: thyroid hormone (th) is essential for normal development, growth and metabolism. its effects were thought to be principally mediated through triiodothyronine (t3), acting as a ligand for the nuclear th receptors (trs) +¦ and +¦ residing on thyroid hormone response elements (tres) in the promoter of th target genes. in this classical model of th action, t3 binding to trs leads to recruitment of basal transcription factors and increased transcription of th responsive genes.recently, the ... | 2011 | 21835053 |
| the association of insulin resistance with subclinical thyrotoxicosis. | background: although overt thyrotoxicosis is associated with reduced insulin sensitivity (is), the effects of subclinical thyrotoxicosis (sctox) (i.e., suppressed serum thyroid-stimulating hormone with free thyroxine and tri-iodothyronine within the reference range) on glucose metabolism are not clear. sctox may be of endogenous origin or due to ingestion of supraphysiological amounts of thyroid hormone. our hypotheses were that reduced is is present in sctox and that the degree of reduction dif ... | 2011 | 21834678 |
| campylobacter jejuni group iii phage cp81 contains many t4-like genes without belonging to the t4-type phage group: implications for the evolution of t4 phages. | cp81 is a virulent campylobacter group iii phage whose linear genome comprises 132,454 bp. at the nucleotide level, cp81 differs from other phages. however, a number of its structural and replication/recombination proteins revealed a relationship to the group ii campylobacter phages cp220/cpt10 and to t4-type phages. unlike the t4-related phages, the cp81 genome does not contain conserved replication and virion modules. instead, the respective genes are scattered throughout the phage genome. mor ... | 2011 | 21697478 |
| naturally resident and exogenously applied t4-like and t5-like bacteriophages can reduce escherichia coli o157:h7 levels in sheep guts. | in preparing sheep for an in vivo escherichia coli o157:h7 eradication trial, we found that 20/39 members of a single flock were naturally colonized by o157:h7-infecting phages. characterization showed these were all one phage type (subsequently named cev2) infecting 15/16 o157:h7, 7/72 ecor and common lab strains. further characterization by pfge (genomeôê+120 kb), restriction enzyme digest (dna appears unmodified), receptor studies (fhua but not tonb is required for infection) and sequencing ( ... | 2011 | 21687531 |
| immune-endocrine interactions in treated and untreated cats naturally infected with fiv. | feline immunodeficiency virus (fiv) is a lentivirus that causes a progressive disruption of immune function in cats. the neuroendocrine and immune systems communicate bidirectionally, mediated by cytokines such as tumour necrosis factor-+¦ (tnf), several interleukins (il-1, il-6, il-10), and through signals induced by the ratio of il-10 to il-12. fiv can affect both pituitary adrenal and thyroid axis function. twenty fiv-infected cats in similar stages of the disease were evaluated for six month ... | 2011 | 21723621 |
| adjuvant chemotherapy improves survival in patients with american joint committee on cancer stage ii colon cancer. | background: it is unclear whether the administration of adjuvant chemotherapy improves survival in patients with american joint committee on cancer (ajcc) stage ii colon cancer. methods: the authors used the state of california cancer surveillance program (csp) to assess patients ages 18 to 80 years with ajcc stage ii colon cancer (ie, t3 or t4 and n0) who underwent surgical resection during 1991 and 2006. patients who had rectal and rectosigmoid cancers were excluded. the cohort was stratified ... | 2011 | 21692068 |
| vitiligo and alopecia areata associated with subclinical/clinical hypothyroidism. | the parents of an 18-year-old woman had noticed white hair while combing their daughter's hair 12 years ago. they found tiny white spots on her scalp, but she was asymptomatic. the spots have since progressed. examination of the affected skin on the scalp was marked by the presence of a chalky/ivory white macule, 8 to 10 cm in diameter, conforming to that of segmental (zosteriformis) vitiligo (figure 1). the lesions were located on the temporoparietal region of the scalp. the hair over the macul ... | 2011 | 21675503 |
| induction/synchronization of oestrus and ovulation in dairy goats with different short term treatments and fixed time intrauterine or exocervical insemination system. | two experiments were carried out on ionica dairy goats in order to test the efficiency of: (1) short term-5-day combined progestogen-pgf2+¦-gnrh treatments on induction/synchronization of oestrus and fertility after natural mating in lactating goats and during the transition period (experiment 1); (2) short term-9-day fga-pgf2+¦-ecg treatments on synchronizing oestrus and ovulation (experiment 2.1) and artificial insemination (ai) fixed time system in synchronized does (experiment 2.2), during t ... | 2011 | 21741783 |
| microbiologic changes in subgingival plaque before and during the early period of orthodontic treatment. | abstract objective: to evaluate changes in subgingival microbiota before and during the leveling and alignment orthodontic stage using the polymerase chain reaction (pcr) method. materials and methods: thirty orthodontic patients (17 females and 13 males; aged 16.7 -¦ 6.5-áy) were included in this study. subgingival microbial samples were taken from the disto-buccal gingival crevice of the left upper central incisors, the left lower central incisors, the mesio-buccal gingival crevice of the left ... | 2011 | 21827233 |
| adjuvant therapy for elderly patients with resected gastric adenocarcinoma: population-based practices and treatment effectiveness. | background: a study was undertaken to determine the survival benefit of postoperative chemoradiation therapy for elderly patients with resected gastric adenocarcinoma. methods: the authors identified 1023 individuals aged 65 years and older (median = 76) who underwent gastrectomy for nonmetastatic stage ib-iv gastric adenocarcinoma diagnosed between 2000 and 2002 in the linked surveillance, epidemiology, and end results-medicare database. they examined factors associated with receiving postopera ... | 2011 | 21692071 |
| lysis from without. | in this commentary i consider use of the term "lysis from without" (lo) along with the phenomenon's biological relevance. lo originally described an early bacterial lysis induced by high-multiplicity virion adsorption and that occurs without phage production (here indicated as lo(v)). notably, this is more than just high phage multiplicities of adsorption leading to bacterial killing. the action on bacteria of exogenously supplied phage lysin, too, has been described as a form of lo (here, lo(l) ... | 2011 | 21687534 |
| accuracy of radiological staging in identifying high-risk colon cancer patients suitable for neoadjuvant chemotherapy: a multicentre experience. | aim:ôçé a pilot study was undertaken to determine the accuracy of ct staging in identifying patients with high risk colon cancers who would be considered a candidates for a neoadjuvant therapy trial (foxtrot) and those at low risk (t1/t2) who would be excluded.. method:ôçé participating radiologists from 19 centres attended workshops for standardisation of image interpretation according to previously defined prognostic criteria: good prognosis tumoursd including, t1/t2, intermediate prognosis, t ... | 2011 | 21689323 |
| leptin stimulates hepatic activation of thyroid hormones and promotes early posthatch growth in the chicken. | hepatic iodothyronine deiodinases (ds) are involved in the conversion of thyroid hormones (ths) which interacts with growth hormone (gh) to regulate posthatch growth in the chicken. previous studies suggest that leptin-like immunoreactive substance deposited in the egg may serve as a maternal signal to program posthatch growth. to test the hypothesis that maternal leptin may affect early posthatch growth through modifying hepatic activation of ths, we injected 5.0++g of recombinant murine leptin ... | 2011 | 21679771 |
| the prognostic importance of midline involvement in oral tongue cancer. | objectives: to examine the importance of midline involvement and other clinicopathologic factors in predicting the rate of contralateral lymph node metastasis and survival in oral tongue squamous cell carcinoma. methods: we used surveillance, epidemiology, and end results data to identify a cohort of 5430 patients with laterally rising tumors. clinicopathologic factors examined as potentially predictive of contralateral lymph node metastasis included extension to midline, t classification, anato ... | 2011 | 21701377 |
| [laryngeal cancer treatment outcomes in our department]. | laryngeal cancer is one of the most common types of head and neck cancer. numerous studies have reported treatment outcomes, and therapeutic approaches and results are generally well established. however, the widespread use of concurrent chemoradiation therapy(ccrt)has led to differences among hospitals in laryngeal preservation rates in patients with t2 and t3 tumors. ccrt is the mainstay of treatment for laryngeal cancer in our department, given our goals of achieving organ and functional pres ... | 2011 | 21829068 |
| the role of radiotherapy for t4 non-melanoma skin carcinoma. | introduction: to review outcomes of patients treated with radiotherapy (rt) for t4 non-melanoma skin cancer (nmsc). methods: a retrospective chart review was performed of 21 patients who received rt for t4 nmsc from 2004 to 2010. outcomes of treatment efficacy, rt technique and patient morbidity were analysed. twelve patients (57.1%) were treated definitively without prior treatment, five (23.8%) were recurrent lesions and four (19.1%) were treated postoperatively. ten patients (47.6%) had evide ... | 2011 | 21843177 |
| radiolocalization of sentinel lymph nodes in clinically n0 laryngeal and hypopharyngeal cancers. | we sought to analyze the characteristics of radioactive lymph nodes with metastatic disease and to explore methods for the localization of sentinel lymph nodes (slns) with radionuclide in clinically n0 laryngeal and hypopharyngeal cancer. | 2011 | 21675592 |
| expression, characterization, and antimicrobial ability of t4 lysozyme from methylotrophic yeast hansenula polymorpha a16. | lysozyme is an enzyme that is essential for protection against bacterial infections. in this study, a t4 lysozyme gene was cloned into the yeast expression vector ppic9k under the control of the pichia pastoris glyceraldehyde-3-phosphate dehydrogenase promoter (pgap). a hansenula polymorpha-derived ribosomal dna (rdna)-targeting element was inserted into the expression vector and was critical for stable dna integration into the h. polymorpha chromosome. recombinant t4 lysozyme was successfully e ... | 2011 | 21706412 |
| variations of brain activities of acupuncture to te5 of left hand in normal subjects. | this paper presents the evident effects of acupoint stimulation, using eeg (electroencephalogram) measurements. with acupuncture stimulation and the eeg measurement on the same meridian, eeg is able to accurately detect the effects of acupunctural point stimulation on brain waves. in this study, 24 subjects without heart or neural diseases were randomly separated into two groups of 12, named test and control groups. similar procedures are performed; the subjects lay on a bed with eyes closed for ... | 2011 | 21721148 |
| effect of prepartum supplementation of selenium and vitamin e on serum se, igg concentrations and colostrum of heifers and on hematology, passive immunity and se status of their offspring. | forty heifers at the late stage of gestation were randomly assigned into five groups. heifers were balanced for age, weight, and time of calving in each group. four and 2-áweeks before expected time of calving, the heifers were injected with 0-áml (c), 10-áml (t1), 20-áml (t2), 30-áml (t3), and 40-áml (t4) se and ve supplements, respectively. each milliliter of the supplement contained of 0.5-ámg se as sodium selenite and 50-áiu of dl-alpha-tocopheryl acetate. blood samples were collected from t ... | 2011 | 21833648 |
| effects of intravesical onabotulinumtoxina on bladder dysfunction and autonomic dysreflexia after spinal cord injury: role of nerve growth factor. | study type - aetiology (case control) level of evidenceôçâ3c what's known on the subject? and what does the study add? neurogenic detrusor overactivity (ndo) and autonomic dysreflexia (ad) are common outcomes following spinal cord injury (sci). in this study, we showed that onabotulinumtoxina controlled ndo and ad in rats with t4-sci, and also provided a mechanism for the control of as. objective: ôçóôçé to assess the significance of onabotulinumtoxina (onabota) intravesical administration in bl ... | 2011 | 21733076 |
| relative hypoadiponectinemia, insulin resistance, and increased visceral fat in euthyroid prepubertal girls with low-normal serum free thyroxine. | a lower activity of the thyroid axis within the clinical reference range is related to a dysmetabolic phenotype in adult populations. we posited that such an association is already present as early as in prepubertal childhood. serum thyroid stimulating hormone (tsh) and free t4, body fat (bioelectric impedance), insulin resistance (homeostasis model assessment of insulin resistance (homa(ir))), total and high molecular weight (hmw)-adiponectin and serum lipids were assessed in 234 euthyroid prep ... | 2011 | 21738234 |
| genome of low-temperature t4-related bacteriophage vb_ecom-vr7. | the complete genome sequence of the t4-related low-temperature escherichia coli bacteriophage vb_ecom-vr7 was determined. the genome sequence is 169,285 bp long, with a g+c content of 40.3%. overall, 95% of the phage genome is coding. it encodes 293 putative protein-encoding open reading frames (orfs) and trna(met). more than half (59%) of the genomic dna lacks significant homology with the dna of t4, but once translated, 72% of the vb_ecom-vr7 genome (211 orfs) encodes protein homologues of t4 ... | 2011 | 21830070 |
| fluorescence amplified fragment length polymorphism for subtyping of genotypes of acanthamoeba isolated from patients with keratitis. | acanthamoeba keratitis (ak) is a painful and vision-threatening ocular infection. the differentiation of acanthamoeba at the species and subspecies level is complicated. nearly all the ak isolates have been shown to belong to t4 genotype when analysed by ribosomal rna gene sequences and there is no universally acceptable method for differentiation of different subtypes of t4. the purpose of this study was to attempt further discrimination of t4 genotypes. | 2011 | 21321424 |
| persistence of goitre in the post-iodization phase: micronutrient deficiency or thyroid autoimmunity? | despite years of salt iodization, goitre continues to be a major public health problem worldwide. we examined the prevalence of goitre in the post-iodization phase and the relationship of goitre with micronutrient status and thyroid autoimmunity in school children of chandigarh, north india. | 2011 | 21321427 |
| megalin and androgen receptor gene expression in young and old human skeletal muscle before and after three sequential exercise bouts. | androgen signaling occurs primarily via the androgen receptor. megalin, a low-density lipoprotein endocytic receptor located in various mammalian tissues, has been recently shown to facilitate sex hormone–binding globulin (shbg) steroid complexes across cell membranes. the purpose of this investigation is to determine if the megalin gene is expressed in human skeletal muscle and if present to determine how megalin and androgen receptor mrna expression change in response to sequential exercise bo ... | 2011 | 21322835 |
| type 2 iodothyronine deiodinase is expressed in human preadipocytes. | type 2 iodothyronine deiodinase (d2) is an enzyme that catalyzes the production of triiodothyronine (t3) from thyroxine (t4) and plays a critical role in providing the local intracellular t3. although d2 is highly expressed in brown adipose tissue, it was thought that d2 is hardly expressed in white adipose tissue. in the present study, we examined whether d2 is expressed in human preadipocytes, using human mesenteric and subcutaneous preadipocytes (hmpa and hscpa, respectively). | 2011 | 21323585 |
| type of skin eruption is an independent prognostic indicator for adult t-cell leukemia/lymphoma. | cutaneous involvement is seen in ~ 50% of adult t-cell leukemia/lymphoma (atll) patients. we investigated the association between skin eruption type and prognosis in 119 atll patients. atll eruptions were categorized into patch (6.7%), plaque (26.9%), multipapular (19.3%), nodulotumoral (38.7%), erythrodermic (4.2%), and purpuric (4.2%) types. when the t stage of the tumor-node-metastasis-blood (tnmb) classification of mycosis fungoides/sézary syndrome was applied to atll staging, 16.0% were t1, ... | 2011 | 21325600 |
| myogenic mrna markers in young and old human skeletal muscle prior to and following sequential exercise bouts. | this study examined how multiple bouts of conventional resistance training affected the mrna expression of transcripts and a protein associated with satellite cell activity in human skeletal muscle. ten younger men (means ± se; age, 21.0 ± 0.5 years; body mass, 82.3 ± 4.2 kg; height, 178.4 ± 2.2 cm; percent body fat, 15.4% ± 2.9%) and 10 older men (age, 66.4 ± 1.6 years; body mass, 94.2 ± 3.7 kg; height, 180.9 ± 2.2 cm; percent body fat, 27.4% ± 1.8%) completed 3 lower-body workouts (monday, wed ... | 2011 | 21326383 |
| the incidence of thyroid dysfunction following radiotherapy for early stage carcinoma of the larynx. | external beam radiotherapy is currently the commonest form of treatment for early laryngeal cancer (t1/2) and thyroid dysfunction is a well recognised complication of this treatment. overt hypothyroidism is a specific clinical disorder which in most patients will be recognized and treated. the problems associated with subclinical hypothyroidism (elevated tsh with normal t4), however, are only now being recognized and their management is to some extent still controversial. the aims of our study a ... | 2011 | 21328003 |
| oncological outcomes in patients undergoing radical nephrectomy and vena cava thrombectomy for renal cell carcinoma with venous extension: a single-centre experience. | to report on the effectiveness of the surgical management of renal cell carcinoma (rcc) in patients with a neoplastic thrombus of the vena cava. | 2011 | 21330093 |
| a randomized phase ii study of 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy compared with bevacizumab plus 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy for intermediate-stage and t4n0-1 head and neck cancers. | introduction: we conducted a randomized phase ii study to evaluate the impact of adding bevacizumab (b) to 5-fluorouracil (5-fu), hydroxyurea (hu), and radiotherapy (fhx) for intermediate-stage and select t4 head and neck squamous cell cancers (hnscc). patients and methods: eligible patients had newly diagnosed hnscc. randomization was 2:1 in favor of bfhx. all patients received 500 mg hu p.o. b.i.d., 600 mg/m(2)/day continuous infusion 5-fu, and b.i.d. radiotherapy with or without bevacizumab 1 ... | 2011 | 21330337 |
| intravitreal recombinant tissue plasminogen activator without and with additional gas injection in patients with submacular haemorrhage associated with age-related macular degeneration. | purpose: to compare intravitreal recombinant tissue plasminogen activator (rt-pa) treatment with and without gas injection in patients with submacular haemorrhage associated with age-related macular degeneration. methods: we conducted a retrospective, non-randomized comparative case study of 110 eyes from 76 women and 34 men (mean age 78.1 ± 6.9 years). evaluations of the data were performed for baseline visit (t1), and visits 1-3 weeks (t2), 3 months (t3) and 6 months after (t4). the patients ... | 2011 | 21332673 |
| thoracoscopic resection of symptomatic herniated thoracic discs: clinical results in 121 patients. | abstract: study design: retrospective review of a prospectively maintained surgical database.objective: report the indications for, surgical procedures performed, and outcomes of the largest series of thoracoscopically treated herniated thoracic discs (htds). we also compared approach-related complications to an unmatched cohort undergoing thoracotomy for htd.summary of background data: symptomatic htds are rare and their surgical management is technically challenging.methods: a prospectively ma ... | 2011 | 21336237 |
| inactivation of escherichia coli and bacteriophage t4 by high levels of dissolved co2. | little information is available regarding the effectiveness of water disinfection by co(2) at low pressure. the aim of this study was to evaluate the use of high levels of dissolved co(2) at 0.3-0.6 mpa for the inactivation of microorganisms. bacteriophage t4 was chosen as the model virus and escherichia coli was selected as the representative bacterium. the results of the study showed a highly effective log inactivation of e. coli and bacteriophage t4 at low and medium initial concentrations by ... | 2011 | 21336924 |
| mycobacterium tuberculosis expresses ftse gene through multiple transcripts. | bacterial ftse gene codes for the atp-binding protein, ftse, which in complex with the transmembrane protein, ftsx, participates in diverse cellular processes. therefore, regulated expression of ftse and ftsx might be critical to the human pathogen, mycobacterium tuberculosis, under stress conditions. although ftsx gene of m. tuberculosis (mtftsx) is known to be transcribed from a promoter inside the upstream gene, ftse, the transcriptional status of ftse gene of m. tuberculosis (mtftse) remains ... | 2011 | 21336990 |
| influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken. | the aim of the study was to investigate the interactions between selenium (se) and various trace elements, both toxic and essential, involved in the antioxidant system. a total of 128 day-old chicks (gallus gallus, broilers) were used to investigate the effect of se yeast supplementation on the accumulation of cadmium (cd), copper (cu) iron (fe) and zinc (zn). there were four replicates of four dietary treatments: t1 (basal diet with no added se, analyzed to contain 0.21 mg kg(-1)), t2 (t1 with ... | 2011 | 21337231 |
| intra-operative radiotherapy of rectal cancer: results of the french multi-institutional randomized study. | to assess efficacy and tolerance of intra-operative radiation therapy (iort) in patients suffering from locally advanced rectal cancer, treated with preoperative radiotherapy followed by surgical resection. | 2011 | 21339010 |
| human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and african americans. | to evaluate the frequency of human papillomavirus-related oropharyngeal squamous cell carcinoma in african americans and whites and to examine patient outcomes in these 2 groups. | 2011 | 21339403 |
| syringomyelia associated with syphilitic spinal meningitis: real complication or possible association? | the study has been designed as a case report. | 2011 | 21339760 |
| clinical evaluation of the function of hypothalamo-pituitary-thyroid axis in children with central nervous system infections. | it is well known that certain non-thyroidal critical illness may lead to euthyroid sick syndrome(ess). there are little reports about the change of thyroid hormone in the children's central nervous system (cns) infections. | 2011 | 21314949 |
| marginal iodide deficiency and thyroid function: dose-response analysis for quantitative pharmacokinetic modeling. | severe iodine deficiency (id) results in adverse health outcomes and remains a benchmark for understanding the effects of developmental hypothyroidism. the implications of marginal id, however, remain less well known. the current study examined the relationship between graded levels of id in rats and serum thyroid hormones, thyroid iodine content, and urinary iodide excretion. the goals of this study were to provide parametric and dose-response information for development of a quantitative model ... | 2011 | 21315791 |
| features of time-intensity curve parameters of colorectal adenocarcinomas evaluated by double-contrast enhanced ultrasonography: initial observation. | purpose: this study is to investigate the value of double contrast-enhanced ultrasonography (dceu) in assessing microcirculation of colorectal adenocarcinomas and to describe the perfusion features of the tumours. material and methods: dceus was performed in 42 patients with adenocarcinoma. the time-intensity curve parameters (arrival time (at), time-to-peak (ttp), peak intensity (pi) and area under the curve (auc)) within the tumours were extracted. the parameters were compared among the tumour ... | 2011 | 21316889 |
| t4 or mi? | 2011 | 21317744 | |
| association of the ugt1a1-53(ta)n polymorphism with l-thyroxine doses required for thyrotropin suppression in patients with differentiated thyroid cancer. | there is a considerable interindividual variation in l-thyroxine [3,5,3',5'-tetraiodo-l-thyronine (t4)] dose required for thyrotropin (thyroid-stimulating hormone) suppression in patients with differentiated thyroid cancer. to investigate whether uridine diphosphate-glucuronosyl transferase 1a1 (ugt1a1)-mediated t4 glucuronidation in liver affects t4 dose, we genotyped 101 patients for the common ugt1a1-53(ta)n polymorphism and compared t4 doses among patients having zero (5/6 and 6/6 genotypes) ... | 2011 | 21317830 |
| concurrent cisplatin, continuous infusion fluorouracil and radiotherapy followed by tailored consolidation treatment in non metastatic anal squamous cell carcinoma. | to evaluate efficacy and feasibility of chemo-radiotherapy in patients with non-metastatic anal squamous-cell-cancer. | 2011 | 21291546 |
| cdna library generation from ribonucleoprotein particles. | most, if not all, known noncoding rnas (ncrnas) are associated with rna binding proteins, thus forming ribonucleoprotein particles or rnps. here we describe a protocol for the generation of a specialized cdna library from rnps, thereby increasing the proportion of functional ncrna species in the library. to that end, cellular extracts are fractionated on 10-30% glycerol gradients. subsequently, rnp-derived ncrnas are isolated and 3'-tailed by cytidine triphosphate and poly(a) polymerase; this is ... | 2011 | 21293458 |
| associations between mercury and hepatic, renal, endocrine, and hematological parameters in atlantic bottlenose dolphins (tursiops truncatus) along the eastern coast of florida and south carolina. | we evaluated associations between total mercury (hg) concentrations in blood and skin and endocrine, hepatic, renal, and hematological parameters in free-ranging bottlenose dolphins (tursiops truncatus). dolphins in indian river lagoon, fl had higher concentrations of hg in blood (0.67 µg/l wet wt) and skin (7.24 µg/g dry wt) compared with those from charleston harbor, sc (0.15 µg/l wet wt, 1.68 µg/g dry wt). an inverse relationship was observed between blood and skin hg concentrations and total ... | 2011 | 21340575 |
| correlation between iodine intake and thyroid function in subjects with normal thyroid function. | excessive iodine intake is known to induce hypothyroidism in people who have underlying thyroid disorders. however, few studies have been performed on subjects with normal thyroid function without a history of autoimmune thyroid disease. we hypothesized that high iodine intake may cause a subtle change in thyroid function even in subjects with normal thyroid function. we analyzed 337 subjects (64 men and 273 women; mean age, 49 years) who showed normal levels of thyroid peroxidase antibodies (tp ... | 2011 | 21340678 |
| localized tongue amyloidosis in a patient with neurofibromatosis type ii. | localized amyloidosis (al) may rarely involve oral mucosa. this is the first known reported case describing the development of tongue al in a 30-year-old patient with neurofibromatosis (nf) type-2. | 2011 | 21340708 |
| prognostic significance of adverse events associated with preoperative radiotherapy for rectal cancer. | adverse events may occur in patients receiving preoperative radiotherapy (prt) for rectal cancers. the aim of this study is to clarify the clinical and pathological features of the patients with prt-related adverse events, and the significance of the adverse events on the clinical outcome. | 2011 | 21340716 |
| differential expression of the a2,3-sialic acid residues in breast cancer is associated with metastatic potential. | aberrant sialylation is closely associated with the malignant phenotype of cancer cells and metastatic potential. however, the precise nature of the molecules in breast cancers has not been unveiled. in this study, we investigated the expression levels of a2,3-sialic acid residues of 50 primary tumor cases, 50 pair-matched lymph node metastasis tumor samples and in the mda-mb-231, t-47d and mcf-7 breast cancer cell lines with different metastatic potential. the expression of a2,3-sialic acid res ... | 2011 | 21344161 |
| total thyroidectomy: a safe and effective treatment for graves' disease. | thyroidectomy as a first line treatment for graves' disease is rarely utilized in the us. the purpose of this study was to analyze the safety and efficacy of thyroid surgery among patients with graves' disease. | 2011 | 21345453 |
| [robotic-assisted laparoscopic radical cystectomy: evaluation of functional and oncological results]. | radical cystectomy remains the most effective treatment for patients with localized, invasive bladder cancer and recurrent noninvasive disease. we report our experience with 84 consecutive cases of robotic assisted laparoscopic radical cystectomy with regard to perioperative results, pathological outcomes and surgical complications. | 2011 | 21345519 |
| effect of subzero-balanced ultrafiltration on lung gas exchange capacity after cardiopulmonary bypass in adult patients with heart valve disease. | this study was conducted to evaluate the effect of a new ultrafiltration technique--the subzero-balanced ultrafiltration (sbuf)--on lung gas exchange capacity after cardiopulmonary bypass (cpb) in adult patients with heart valve disease. | 2011 | 21345773 |
| rna and dna bacteriophages as molecular diagnosis controls in clinical virology: a comprehensive study of more than 45,000 routine pcr tests. | real-time pcr techniques are now commonly used for the detection of viral genomes in various human specimens and require for validation both external and internal controls (ecs and ics). in particular, ics added to clinical samples are necessary to monitor the extraction, reverse transcription, and amplification steps in order to detect false-negative results resulting from pcr-inhibition or errors in the technical procedure. here, we performed a large scale evaluation of the use of bacteriophag ... | 2011 | 21347398 |
| risk factors and clinical courses of chemoradiation-related arterio-esophageal fistula in esophageal cancer patients with clinical invasion of the aorta. | although concurrent chemoradiotherapy (crt) is a standard treatment for esophageal cancer invading adjacent structures (t4-ec), arterio-esophageal fistula (aef) occurs occasionally as a critical adverse event of t4-ec with crt. the frequency, clinical course, and risk factors of aef related to crt are not well known. | 2011 | 21347631 |
| [horner syndrome and brachial plexus blockade after epidural anesthesia for obstetric labor and cesarean section]. | a 30-year-old woman (asa ii, obese) in her 40th week of a first pregnancy required epidural analgesia for labor. when the cervix had dilated to 5 cm, the epidural infusion was started with a 9-ml bolus of 0.2% ropivacaine and 50 pg of fentanyl, after a negative test dose. an infusion of 0.2% ropivacaine and 1 microg/ml of fentanyl was started at a rate of 8 ml/h. a cesarean section was required after insufficient progress was made during 8 hours of labor. eight milliliters of 0.75% ropivacaine w ... | 2011 | 21348219 |
| predictors of the use of supplemental androgen suppression therapy and external beam radiation in men with high-risk prostate cancer undergoing brachytherapy in community practice. | we assessed clinical- and practice-related variables associated with the use of trimodality treatment (androgen suppression therapy, external beam radiation therapy, and brachytherapy) in a community-based cohort of men with high-risk prostate cancer. | 2011 | 21349778 |
| elevated thyroid-stimulating hormone level in a euthyroid neonate caused by macro thyrotropin-igg complex. | elevated thyroid-stimulating hormone (tsh) was discovered by routine neonatal screening in a newborn with no clinical symptoms. thyroid function tests were repeated and confirmed a high tsh value but normal total thyroxine (t4) and triiodothyronine (t3). however, the mother also had elevated serum tsh with normal levels of t4 and t3. the results suggested a transmitted maternal interfering factor, and no treatment was started while further investigation was performed. gel filtration chromatograp ... | 2011 | 21352360 |
| tumor length as a prognostic factor in esophageal squamous cell carcinoma. | tumor size is an important prognostic factor in many cancers, but its role in esophageal cancer remained undetermined. the aim of this study is to investigate the impact of tumor length on survival for patients with resected esophageal squamous cell carcinoma. | 2011 | 21353021 |
| thyroid-stimulating hormone (tsh): measurement of intracellular, secreted, and circulating hormone in xenopus laevis and xenopus tropicalis. | thyroid-stimulating hormone (tsh) is an important regulator of the hypothalamic-pituitary-thyroid (hpt) axis in xenopus laevis. to evaluate the role of this hormone on developing tadpoles, immunologically-based western blots and sandwich elisas were developed for measuring intracellular (within pituitaries), secreted (ex vivo pituitary culture), and circulating (serum) amounts. despite the small size of the tadpoles, these methods were able to easily measure intracellular and secreted tsh, and c ... | 2011 | 21354158 |
| discrepancies between two alternative staging systems (european neuroendocrine tumor society 2006 and american joint committee on cancer/union for international cancer control 2010) of neuroendocrine neoplasms of the pancreas. a study of 50 cases. | the aim of our study was to identify and describe potential inconsistencies between two alternative staging systems of pancreatic neuroendocrine neoplasms (pnens)--the european neuroendocrine tumor society (enets) system (2006) and the american joint committee on cancer/union for international cancer control (ajcc-uicc) system (2010). to address this issue, we performed a retrospective clinico-pathological study of 50 cases of pnens. we found 9 (18%) cases of enets/ajcc-uicc discrepancies regard ... | 2011 | 21354717 |
| [reference values for thyroid hormones in the population of pregnant women in jaen (spain)]. | to evaluate thyroid function in the three trimesters of pregnancy in healthy women taking iodine and to define the reference ranges of normality in this population. | 2011 | 21354872 |
| a promiscuous dna packaging machine from bacteriophage t4. | complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. during genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. the capsid expands after about 10%-25% of the genome is packaged. when the head is full, the motor cuts the concatemeric dna and dissociates from the head. conformational changes, particularly in the portal, are thought to drive these sequential tr ... | 2011 | 21358801 |
| factors influencing the outcome of breast cancer patients with 10 or more metastasized axillary lymph nodes. | background: the purpose of this study was to investigate prognostic factors in breast cancer patients with metastasis of ten or more lymph nodes (pathologic n3a). methods: we conducted a retrospective analysis of the cases of 304 breast cancer patients with pathologic n3a disease who had undergone definitive surgery between 1986 and 2006, and investigated the correlation between clinicopathologic characteristics and treatment outcomes. results: with a median follow-up period of 55 months, the 5- ... | 2011 | 21360123 |
| first trimester maternal serum papp-a and free ß-hcg levels in hyperemesis gravidarum. | to evaluate whether hyperemesis gravidarum (hg) affects first-trimester maternal serum papp-a and free ß-hcg levels. | 2011 | 21360554 |
| effects of propofol anesthesia and sevoflurane anesthesia on the differentiation of human t-helper cells during surgery. | surgical stress causes a helper t-cell type 2 (th2)-dominant status and disturbs the th1/th2 cytokine balance. anesthesia can suppress the stress response to surgery, therefore it may inhibit the imbalance in the th1/th2 ratio. in this study, we assessed if propofol anesthesia and sevoflurane anesthesia influence the th1/th2 cytokine balance, and which anesthesia method better attenuates this ratio. | 2011 | 21362275 |
| effect of intraoperative saline fill volume on perioperative outcomes in tissue expander breast reconstruction. | the effect of tissue expander saline fill volume on perioperative complications in breast reconstruction is unclear. the authors evaluated patients undergoing immediate breast reconstruction with tissue expanders with varying saline fill volumes to determine patient-, surgery-, and disease-related factors associated with complication risk. | 2011 | 21364408 |
| hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development. | notch signalling plays an important role in endocrine development, through its target gene hes1. hes1, a bhlh transcriptional repressor, influences progenitor cell proliferation and differentiation. recently, hes1 was shown to be expressed in the thyroid and regulate expression of the sodium iodide symporter (nis). to investigate the role of hes1 for thyroid development, we studied thyroid morphology and function in mice lacking hes1. during normal mouse thyroid development, hes1 was detected fr ... | 2011 | 21364918 |
| potentially pathogenic free-living amoebae isolated from hospital wards with immunodeficient patients in tehran, iran. | this study investigated the occurrence of free-living amoebae (fla) in immunodeficiency wards of hospitals in tehran, iran. a total of 70 dust and biofilm samples from wards serving transplant, pediatric (malignancies), hiv, leukemia and oncology patients of five university hospitals were collected and examined for the presence of fla using culturing and molecular approaches. based on the morphology of the amoebae in plate cultures, primer sets were applied for molecular identification of acanth ... | 2011 | 21365453 |
| perinatal exposure to low-dose de-71 increases serum thyroid hormones and gonadal osteopontin gene expression. | polybrominated diphenyl ethers (pbdes) are flame retardants that have been widely used in manufacturing. they are major household and environmental contaminants that bioaccumulate. humans are exposed primarily through dust inhalation and dietary ingestion of animal products. in animal studies, high doses of penta-brominated diphenyl ethers (penta-bdes) in the mg/kg body weight (bw) range negatively impact brain development, behavior, memory, circulating thyroid hormone concentrations, the reprod ... | 2011 | 21367881 |
| transverse mesocolon invasion in advanced gastric cancer: should we reconsider current t staging? | according to the ajcc/uicc tnm classification, t mesocolon invasion in agc is classified as t2b or t3 according to the presence or the absence of serosa invasion. however, many authors have considered t mesocolon invasion in agc as t4. this study was performed to evaluate the appropriate t stage for t mesocolon invasion in agc. | 2011 | 21369743 |
| engineered t4 viral nanoparticles for cellular imaging and flow cytometry. | viruses are of particular interest as scaffolds for biotechnology applications given their wide range of shapes and sizes and the possibility to modify them with a variety of functional moieties to produce useful virus-based nanoparticles (vnps). in order to develop functional vnps for cell imaging and flow cytometry applications, we used the head of the t4 bacteriophage as a scaffold for bioconjugation of fluorescent dyes. bacteriophage t4 is a double-stranded dna virus with an elongated icosah ... | 2011 | 21375348 |
| efficacy and safety of radiotherapy in acromegaly. | transsphenoidal surgery remains the treatment of choice in acromegaly, yet 40-50% of patients require secondary forms of therapy such as radiation therapy (rt) and somatostatin analogues (sa). we undertook this study to evaluate the efficacy and safety of rt in acromegaly. | 2011 | 21376263 |
| comparison of volume-controlled and pressure-controlled ventilation in steep trendelenburg position for robot-assisted laparoscopic radical prostatectomy. | to compare the effects of volume-controlled ventilation (vcv) and pressure-controlled ventilation (pcv) on respiratory mechanics and hemodynamics in steep trendelenburg position. | 2011 | 21377341 |
| the pituitary-thyroid axis during the parr-smolt transformation of coho salmon, oncorhynchus kisutch: quantification of tsh ß mrna, tsh, and thyroid hormones. | the objective of this investigation was to quantify pituitary thyroid stimulating hormone (tsh) ß mrna, pituitary and plasma tsh and plasma thyroid hormone levels during the parr-smolt transformation of coho salmon that occurs in spring from february to may. the status of the pituitary-thyroid axis was assessed using an rnase protection assay for pituitary tsh ß mrna and radioimmunoassays for salmon pituitary and plasma tsh and thyroid hormones. tsh ß mrna was highest during late winter (februar ... | 2011 | 21377468 |
| signs of overload after an intensified training. | this study investigated effects of a 9-week intensified aerobic training and 3-weeks of recovery on signs of overload in 9 healthy active young males. blood and saliva samples were collected and psychological questionnaires were administered during baseline (t1), intermediate load (t2), maximal load (t3), and recovery (t4) periods. maximal oxygen uptake increased and blood lactate concentration decreased in t3, while running time in a 3ôçë000ôçë m track field test was significantly shorter. no s ... | 2011 | 21380974 |
| dietary administration of bacillus thuringiensis on the cellular innate immune response of african catfish (clarias gariepinus) against aeromonas hydrophila. | an experiment was conducted to evaluate the use of bacillus thuringiensis (bt) as a probiotic to enhance the cellular innate immune response of the african catfish (clarias gariepinus) challenged with a bacterial fish pathogen, aeromonas hydrophila. | 2011 | 21381499 |
| hormones of hypothalamic-pituitary-thyroid axis are significant regulators of synthesis and secretion of vitamin k-dependent plasma coagulation factors. | present data about hormonal regulation of haemostasis are often contradictory and are mostly based on clinical observations. the aim of the current research is to study the effects of the hormones of hypothalamic-pituitary-thyroid (hpt) axis on plasma levels (i.e. on the synthesis and secretion) of vitamin k-dependent coagulation factors in rats. the study was carried out on 65 male wistar rats, divided into five groups. the animals were injected subcutaneously (s.c.) once daily for three consec ... | 2011 | 21382270 |
| effects of zoledronic acid on sutural bone formation: a computed tomography study. | the aim of this study was to investigate the effects of systemically applied zoledronic acid (za) on osteoblastic bone formation and relapse in the rat sagittal suture after expansion. eighteen 12-week-old male wistar rats were divided into three groups. in groups 1 and 2, a saline solution was given subcutaneously after expansion and the retention period lasted for 14 and 7 days, respectively. in group 3, 0.1 mg of za was diluted with saline and given subcutaneously after expansion: the retenti ... | 2011 | 21382907 |
| effect of long-term music therapy intervention on autonomic function in anthracycline-treated breast cancer patients. | anthracyclines are potent antineoplastic agents associated with cardiotoxicity, which may lead to congestive heart failure, causing impairment of autonomic cardiovascular function as assessed by heart rate variability (hrv). this decreases survival rates. this study aimed to determine whether music therapy intervention improves autonomic function in anthracyclinetreated breast cancer patients, and if so, whether such improvements persist after cessation of the intervention. participants were 12 ... | 2011 | 21382955 |