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frequency and antibiogram of isolates from surgical units of a tertiary care hospital in quetta.to determine the frequency and antibiogram of the isolates from infected patients in surgical units of a tertiary care hospital.201728406770
synthesis and characterization of tetrahydropyran-based bacterial topoisomerase inhibitors with antibacterial activity against gram-negative bacteria.there is an urgent unmet medical need for novel antibiotics that are effective against a broad range of bacterial species, especially multidrug resistant ones. tetrahydropyran-based inhibitors of bacterial type ii topoisomerases (dna gyrase and topoisomerase iv) display potent activity against gram-positive pathogens and no target-mediated cross-resistance with fluoroquinolones. we report our research efforts aimed at expanding the antibacterial spectrum of this class of molecules toward difficu ...201728406300
a topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity.many infectious diseases are associated with multidrug-resistant (mdr) bacteria residing in biofilms that require high antibiotic concentrations. while oral drug delivery is frequently ineffective, topical treatments have the potential to deliver higher drug concentrations to the infection site while reducing systemic side effects. this study determined the antibiofilm activity of a surgical wound gel loaded with the iron chelator deferiprone (def) and the heme analogue gallium-protoporphyrin (g ...201728396543
in vitro selection and identification of potential probiotics isolated from the gastrointestinal tract of nile tilapia, oreochromis niloticus.fish gut bacteria can be used as probiotics for aquaculture. the aim of this study is to screen and identify beneficial probiotic bacteria from the gut of nile tilapia, oreochromis niloticus. nine out of one hundred thirty-five isolates were non-pathogenic through intraperitoneal injection and had antibacterial activities with at least a strain from the five isolated fish pathogens, aeromonas sobria, aeromonas hydrophila, pseudomonas aeruginosa, pseudomonas putida, and staphylococcus aureus. fur ...201728819794
assessment of cultivable oral bacterial flora from important venomous snakes of india and their antibiotic susceptibilities.snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of india. snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. the pathogens from the oral cavity of the snake tend to initiate an infection, resulting ...201728733908
haematological changes in south indian fresh water murrel, channa punctatus have both eus and a. hydrophila infection.the mixed infection in fishes is a common feature and in this pathogens like bacteria, fungi and protozoan's are found together to cause ill health to the fishes known as epizootic ulcerative syndrome (eus). in this syndrome the low temperature and aquatic pollution aggravates the infection in fishes. in the present study the fresh water edible fish, channa punctatus (murrel) was found infected with the bacteria namely, aeromonas hydrophila, staphylococcus aureus, pseudomonas aeruginosa and salm ...201728615835
a c-type lectin, nattectin-like protein (cantc) in qihe crucian carp carassius auratus: binding ability with lps, pgn and various bacteria, and agglutinating activity against bacteria.c-type lectins (ctls), as the members of pattern-recognition receptors (prrs), play the significant roles in innate immunity through binding with pathogen-associated molecular patterns (pamps) on the surface of microbe. in the present study, a novel ctl, nattectin-like protein (named as cantc), was investigated in qihe crucian carp carassius auratus. the full-length cdna of cantc was composed of 776 bp, with a 152 bp 5'-untranslated region (utr), a 492 bp orf encoding a 163-aa protein, and a 132 ...201728602683
the prevalence of antibiotic-resistant bacteria (arb) in waters of the lower ballona creek watershed, los angeles county, california.screening for the prevalence of antibiotic-resistant bacteria (arb) was done at the ballona creek and wetlands, an urban-impacted wetland system in los angeles, california. the goals were (1) to assess the overall prevalence of arb, and (2) compare differences in arb abundance and the types of antibiotic resistance (ar) among the following sample types: lagoon water from del rey lagoon, urban runoff from ballona creek, and water from the ballona wetlands (tidal water flooding in from the adjacen ...201728488226
antagonistic properties of some halophilic thermoactinomycetes isolated from superficial sediment of a solar saltern and production of cyclic antimicrobial peptides by the novel isolate paludifilum halophilum.this study has focused on the isolation of twenty-three halophilic actinomycetes from two ponds of different salinity and the evaluation of their ability to exert an antimicrobial activity against both their competitors and several other pathogens. from the 23 isolates, 18 strains showed antagonistic activity, while 19 showed activities against one or more of the seven pathogen strains tested. six strains exhibited consistent antibacterial activity against gram-negative and gram-positive pathoge ...201728819625
the antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human hel 12469 cells.six essential oils (from oregano, thyme, clove, lavender, clary sage, and arborvitae) exhibited different antibacterial and antifungal properties. antimicrobial activity was shown against pathogenic (escherichia coli, salmonella typhimurium, yersinia enterocolitica, staphylococcus aureus, listeria monocytogenes, and enterococcus faecalis) and environmental bacteria (bacillus cereus, arthrobacter protophormiae, pseudomonas fragi) and fungi (chaetomium globosum, penicillium chrysogenum, cladospori ...201728811611
production, characterization, and antimicrobial activity of mycocin produced by debaryomyces hansenii dsmz70238.the present study was conducted to estimate the antimicrobial activity and the potential biological control of the killer toxin produced by d. hansenii dsmz70238 against several pathogenic microorganisms. in this study, the effects of nacl, ph, and temperature, killer toxin production, and antimicrobial activity were studied. the results showed that the optimum inhibitory effect of killer toxin was at 8% nacl, and the diameters of clear zones were 20, 22, 22, 21, 14, and 13 mm for staphylococcus ...201728757872
spectroscopic characterisation of two polyketide metabolites from cylindrocarpon sp. from driftwood.two new polyketides, (5r,7r,9r)-7,9-dihydroxy-5-decanolide and (4e,6r,9r)- 6,9-dihydroxydec-4-enoic acid (2), were isolated from rice cultures of cylindrocarpon sp. sy-39 discovered during screening of driftwood at a shonai coast area in yamagata, japan. the structures of 1 and 2 were determined using a variety of spectroscopic methods. compound 2 exhibited moderate antimicrobial activity against staphylococcus aureus nbrc 13276 and aspergillus clavatus f 318a at a concentration of 50 μg per dis ...201728562088
evaluation of anthelmintic antimicrobial and antioxidant activity of chenopodium album.the objective of this study was to evaluate the anthelmintic, antimicrobial and antioxidant activities of chenopodium album against gastrointestinal nematodes of sheep and some pathogenic microbes. a worm motility inhibition assay was used for in vitro study, and a faecal egg count reduction assay was used for an in vivo study. various concentrations ranging from 100 to 500 μg/ml of the extract were subjected to antimicrobial screening by disc diffusion method against four selected bacterial (st ...201728735356
production of recombinant antimicrobial polymeric protein beta casein-e 50-52 and its antimicrobial synergistic effects assessment with thymol.accelerating emergence of antimicrobial resistance among food pathogens and consumers' increasing demands for preservative-free foods are two contemporary challenging aspects within the food industry. antimicrobial packaging and the use of natural preservatives are promising solutions. in the present study, we used beta-casein-one of the primary self-assembly proteins in milk with a high polymeric film production capability-as a fusion partner for the recombinant expression of e 50-52 antimicrob ...201728561787
phytochemical screening, antimicrobial and cytotoxicity studies of ethanol leaf extract of aphaniasenegalensis (sapindaceae).aphania senegalensis (sapindaceae) is commonly used in senegalese traditional medicine to treat pain, inflammation, asthenia, bacterial and fungal infections. the aim of this study was to determine the type of phytochemical constituents present in the ethanol leaf extract and its antimicrobial activity against selected bacterial and fungal pathogens.201728638876
synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs.new benzimidazole analogs were prepared and tested for antimicrobial efficacy toward escherichia coli atcc 12435, bacillus cereus uw 85, staphylococcus aureus atcc 29213, candida albicans and aspergillus fumigatus 293. results indicated that compound 10 has potent and broad spectrum antimicrobial activity. in addition, 4b and 5c showed eminent antimicrobial efficacy toward b. cereus, s. aureus, c. albicans and a. fumigatus. furthermore, 12 and 14 demonstrated interesting antifungal activity towa ...201728623814
post-tuberculosis mycetoma: bronchoscopic removal.a 76-year-old male non-smoker presented to our institution with cough and haemoptysis. he had been treated for cavitatory pulmonary mycobacterium tuberculosis of the right upper lobe 10 years previously. chest radiograph and subsequent computed tomography (ct) of the chest demonstrated a right upper cavity containing a mass suspicious for mycetoma. flexible bronchoscopy under conscious sedation demonstrated a mass obstructing the anterior segment of the right upper lobe. the abnormality was subs ...201728580148
microbiology of the upper and lower airways in pediatric cystic fibrosis patients.objective to evaluate the microbiology of the upper and lower airways in pediatric cystic fibrosis (cf) patients who underwent sinus surgery. study design retrospective case series with chart review. setting tertiary care children's hospital. subjects and methods a total of 201 paired sinus and pulmonary cultures from 105 cf patients were identified between 1996 and 2014. demographics and culture results were analyzed. results the mean age of patients was 11.2 ± 5.4 years (range, 1-27 years), an ...201728440108
antimicrobial activity and chemical composition of brunfelsia uniflora flower oleoresin extracted by supercritical carbon dioxide.brunfelsia genus is traditionally utilized in popular medicine due to its antibacterial and antifungal properties to name but a few. however, studies on the antimicrobial activity of brunfelsia uniflora flower oleoresin have not been found yet. this study aimed to evaluate the chemical composition and antimicrobial activity of b. uniflora flower oleoresin obtained by supercritical carbon dioxide. oleoresin from the plant dried flowers was obtained by carbon dioxide, and the chemical composition ...201728407186
biogenic fabrication of cunps, cu bioconjugates and in vitro assessment of antimicrobial and antioxidant activity.in the present study, the authors synthesised copper nanoparticles (cunps) by using extract of zingiber officinale (ginger) and later the nps were bioconjugated with nisin, which shows antimicrobial activity against food spoilage microorganisms. cunps and its bioconjugate were characterised by ultraviolet-vis spectroscopy, np tracking analysis, zetasizer, transmission electron microscopy analysis, x-ray diffraction and fourier transform infra-red (ftir) spectroscopy. zeta potential of cunps and ...201728745291
ultrasound assisted phytosynthesis of iron oxide nanoparticle.the present work deals with the ultrasound assisted green synthesis of iron oxide nano particle using coriandrum sativum leaf extract as a reducing agent. the synthesized iron oxide nanoparticle was confirmed by uv spectra. the characterization was done to know more about morphology and size of the particle by sem analysis which shows spherical particles with size ranging from 20 to 90nm. the antimicrobial activity of the leaf extract and the synthesized nanoparticles was studied against the pat ...201728732967
green synthesis and characterization of gold and silver nanoparticles using mussaenda glabrata leaf extract and their environmental applications to dye degradation.plant-derived nanomaterials opened a green approach in solving the current environment issues. present study focused on rapid microwave-assisted synthesis and applications of gold and silver nanoparticles mediated by aqueous leaf extract of mussaenda glabrata. the synthesized nanoparticles were characterized by uv-vis, ft-ir, powder xrd, energy-dispersive x-ray spectroscopy (edx), transmission electron (tem), and atomic force microscopic techniques (afm). fcc crystal structure of both nanopartic ...201728589274
preparation of chitosan-tio2 composite film with efficient antimicrobial activities under visible light for food packaging applications.by incorporation of tio2 nano-powder in chitosan, a chitosan-tio2 composite film was prepared with efficient antimicrobial activity against food-borne pathogenic microbes and expected to be a promising food packaging material. scanning electron microscopy analysis showed that the tio2 nano-powder was successfully and uniformly dispersed into the chitosan matrix. tio2 addition led to enhanced hydrophilicity, to better mechanical properties, and to decreased light transmittance in visible light re ...201728504125
design, synthesis, and biological evaluation of vanillin hydroxamic acid derivatives as novel peptide deformylase inhibitors.infectious disease is increasingly hampering human health, which challenge the discovery of new antibacterial target. peptide deformylase (pdf), a metalloenzyme responsible for catalyzing the remove of the n-formyl group from nascent proteins, was considered as an important target in antibacterial drug discovery.201728606047
antibacterial constituents from antarctic fungus, aspergillus sydowii sp-1.one new alkaloid, named as acremolin c (1), was isolated from static culture of antarctic fungus, aspergillus sydowii sp-1, in an investigation of the antimicrobial constituents of this antarctic microorganism, and its structure was determined by spectroscopic methods. additionally, four known compounds, cyclo-(l-trp-l-phe) (2), 4-hydroxyphenylacetic acid (3), (7s)-(+)-hydroxysydonic acid (4) and (7s, 11s)-(+)-12-hydroxysydonic acid (5), were isolated and identified. biological studies disclosed ...201728602098
bio-mining the forest ecosystem of north east india for identification of antimicrobial metabolites from fungi through submerged fermentation.in this study, fungi isolated from less explored forest soil ecosystem of northeast india were studied for the production of potential antimicrobial metabolites (amm). out of the 68 fungi isolated from forest soil of manipur, 7 of them showed ama against the test pathogens. among them, aspergillus terreus (ibsd-f4) showed the most significant activity against staphylococcus aureus (atcc-25923), bacillus anthracis (ibsd-c370), pseudomonas fluorescens (atcc-13525), salmonella typhimurium (atcc-140 ...201728578806
effects of lactobacillus rhamnosus and lactobacillus acidophilus on bacterial vaginal pathogens.the human vagina is colonized by a variety of microbes. lactobacilli are the most common, mainly in healthy women; however, the microbiota composition can change rapidly, leading to infection or to a state in which potential pathogenic microorganisms co-exist with other commensals. in premenopausal women, urogenital infections, such as bacterial vaginosis and aerobic vaginitis, remain an important health problem. treatment of these infections involves different kind of antibiotics; however, the ...201728580872
characterisation and antimicrobial activity of biosurfactant extracts produced by bacillus amyloliquefaciens and pseudomonas aeruginosa isolated from a wastewater treatment plant.biosurfactants are unique secondary metabolites, synthesised non-ribosomally by certain bacteria, fungi and yeast, with their most promising applications as antimicrobial agents and surfactants in the medical and food industries. naturally produced glycolipids and lipopeptides are found as a mixture of congeners, which increases their antimicrobial potency. sensitive analysis techniques, such as liquid chromatography coupled to mass spectrometry, enable the fingerprinting of different biosurfact ...201728571306
functional silver nanocomposites as broad-spectrum antimicrobial and biofilm-disrupting agents.biofilms' tolerance has become a serious clinical concern due to their formidable resistance to conventional antibiotics and prevalent virulence. therefore, there is an urgent need to develop alternative antimicrobial agents to eradicate biofilms but avoid using antibiotics. herein, we successfully developed polymer functional silver nanocomposites by reduction of silver nitrate in the presence of a biocompatible carbohydrate polymer and a membrane-disrupting cationic polymer. the nanocomposites ...201728481506
elucidation of the recognition sequence of sortase b from bacillus anthracis by using a newly developed liquid chromatography-mass spectrometry-based method.sortases are enzymes that are responsible for the attachment of secreted proteins to the cell wall of gram-positive bacteria. hereby, the sortases recognize short, five-residue amino acid sequences present in the target proteins and fuse them to the peptidoglycan layer via a transpeptidation reaction, creating a new peptide bond between the c-terminus of the recognition sequence and the cell wall. the transpeptidation activity of sortases is widely used in protein engineering for modification of ...201728475305
antimicrobial and antioxidant activities of the extract and fractions of tetradenia riparia (hochst.) codd (lamiaceae) leaves from brazil.tetradenia riparia (lamiaceae) is native to central africa popularly known as myrrh, used in folk medicine to treat various diseases like malaria, gastroenteritis, and tropical skin disease. this research was to evaluate the antioxidant and antibacterial activities of the crude extract (ce) and fractions (fr) of the t. riparia by classical chromatography. the ce of t. riparia leaves was submitted to column chromatographic fractionation to obtain four fractions of the interest, which were identif ...201728840299
antimicrobial activity of endophytic bacterial populations isolated from medical plants of iran.endophytic actinobacteria colonize inside the plant tissues without causing damages to the host plant. since these microorganisms colonize in the different parts of plants and can stop plant disease, they have been applied as biological agents for controlling human diseases. the aim of this study was molecular identification and measuring the antimicrobial activity of endophytic actinomycetes isolated from medicinal plants of iran.201728775818
phenolic acids and flavonoids of peanut by-products: antioxidant capacity and antimicrobial effects.peanut skin (ps) and meal from dry-blanched peanuts (mdbp) were evaluated as sources of phenolic compounds. ps rendered the highest total phenolic content, antioxidant capacity towards abts radical cation, dpph and hydroxyl radicals as well as reducing power. phenolic acids were present in ps and mdbp whereas proanthocyanidins and monomeric flavonoids were found only in ps as identified by hplc-dad-esi-ms(n). procyanidin-rich extracts prevented oxidation in non-irradiated and gamma-irradiated fi ...201728764032
formulation of menthol-loaded nanostructured lipid carriers to enhance its antimicrobial activity for food preservation.purpose: due to the antimicrobial property, menthol have significant potential for food preservation and foodstuff shelf life improvement. nevertheless, menthol instability, insolubility, and rapid crystallization in aqueous media make it unsuitable for used in food products. this work was aimed to prepare menthol-loaded nanostructured lipid carriers (nlcs) to enhance its antimicrobial activity. methods: morphology, particle size and size distribution, encapsulation efficiency percent (ee%), and ...201728761828
cyclohexene-fused 1,3-oxazines with selective antibacterial and antiparasitic action and low cytotoxic effects.oxazine derivatives, a class of heterocyclic compounds, exhibit a variety of biological properties, such as anticonvulsant and antitumor activities. in this study, we evaluated the effect of two cyclohexene-fused 1,3-oxazines (cis‑1-benzyl-n-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (1) and trans‑n-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (2)) in cultures of bacillus cereus, enterococcus faecalis, escherichia coli, klebsiella pneumoniae, salmonella enterica, serratia mar ...201728755871
antibacterial activity of fusion from biosynthesized acidocin/silver nanoparticles and its application for eggshell decontamination.bacteriocins from lactic acid bacteria (lab) are useful to control the persistent development of pathogenic microorganisms in food and medicine fields. the bacteriocin acidocin was extracted from lactobacillus acidophilus m1 that was isolated from fermented milk, purified using ammonium sulphate fractionation, and gel filtration column chromatography using sephadex matrix and applied as a potential antibacterial agent. the molecular weight of the purified acidocin was estimated using sds-page to ...201728736866
characterization of enterotoxigenic bacillus cereus sensu lato and staphylococcus aureus isolates and associated enterotoxin production dynamics in milk or meat-based broth.bacillus cereus sensu lato species, as well as staphylococcus aureus, are important pathogenic bacteria which can cause foodborne illness through the production of enterotoxins. this study characterised enterotoxin genes of these species and examined growth and enterotoxin production dynamics of isolates when grown in milk or meat-based broth. all b. cereus s. l. isolates harboured nhea, hbla and entfm toxin genes, with lower prevalence of bcet and hlyii. when grown at 16 °c, toxin production by ...201728714887
detection of eight foodborne bacterial pathogens by oligonucleotide array hybridization.simultaneous and rapid detection of multiple foodborne bacterial pathogens is important for the prevention of foodborne illnesses.201728713514
enhanced antibacterial activity of ent-labdane derivatives of salvic acid (7α-hydroxy-8(17)-ent-labden-15-oic acid): effect of lipophilicity and the hydrogen bonding role in bacterial membrane interaction.in the present study, the antibacterial activity of several ent-labdane derivatives of salvic acid (7α-hydroxy-8(17)-ent-labden-15-oic acid) was evaluated in vitro against the gram-negative bacterium escherichia coli and the gram-positive bacteria staphylococcus aureus and bacillus cereus. for all of the compounds, the antibacterial activity was expressed as the minimum inhibitory concentration (mic) in liquid media and minimum inhibitory amount (mia) in solid media. structure activity relations ...201728644410
high level bacterial contamination of secondary school students' mobile phones.while contamination of mobile phones in the hospital has been found to be common in several studies, little information about bacterial abundance on phones used in the community is available. our aim was to quantitatively determine the bacterial contamination of secondary school students' mobile phones.201728626737
isolation, morphological identification and in vitro antibacterial activity of endophytic bacteria isolated from azadirachta indica (neem) leaves.the objective of this study was to isolate endophytic bacteria from azadirachta indica (neem) leaves, their identification and investigate their antibacterial activity against three gram-positive bacteria, staphylococcus aureus, streptococcus pyogenes and bacillus cereus and gram-negative bacteria escherichia coli, salmonella typhimurium and klebsiella pneumoniae.201728620254
isolation and preliminary characterization of a bacteriocin-producer bacillus strain inhibiting methicillin resistant staphylococcus aureus.in a multivalent approach to discover new antimicrobial substance, a total of 160 bacilli were isolated from termitarium soil, characterized on the basis of their morphological and physiological characters and screened for their antimicrobial activity by agar well diffusion method against certain drug resistant pathogenic bacteria such as staphylococcus aureus, methicillin resistant staphylococcus aureus and common food contaminating bacteria listeria monocytogenes. after preliminary screening, ...201728605978
characterization of hypericum perforatum polysaccharides with antioxidant and antimicrobial activities: optimization based statistical modeling.in this study, the extracting parameters of crude polysaccharides (cpss) from the hypericum perforatum (hp) including extraction time (eti, 60-180min), extraction temperature (ete, 60-90°c), and the water/solid ratio (w/s, 10-30 was optimized by using three-variable-three-level box-behnken design-response surface methodology (bbd-rsm) based on the single-factor experiments. the optimal extraction conditions were as follow: eti 117.5min, ete 74.28°c, and w/s 20.3:1. under these conditions, the ex ...201728602988
an enhancement of antimicrobial efficacy of biogenic and ceftriaxone-conjugated silver nanoparticles: green approach.of the various methods explored for the synthesis of nanoparticles, biogenesis of silver nanoparticles (agnps) received great attention due to their versatile properties. in this report, daucus carota extract was used for the synthesis of agnps and ceftriaxone was conjugated with agnps to enhance their antimicrobial efficacy. the conjugated and unconjugated agnps were characterized by adopting uv-vis spectroscopy, ftir, afm, dls, and tem, which revealed the spr peak at 420 nm and spherical shape ...201728600792
heteroleptic metal(ii) complexes of hydrotris(methimazolyl)borate and diimines: synthesis, theoretical calculations, antimicrobial, antioxidant, in vitro cytotoxicity and molecular docking studies.a series of heteroleptic metal(ii) complexes of formulation [m(tm)(diimine)](clo4) (1-8), [tm = hydrotris(methimazolyl)borate, diimine = 2,2'-bipyridyl or 1,10-phenanthroline and m = mn(ii), ni(ii), cu(ii) or zn(ii)] have been synthesized and characterized by spectroscopic methods. the geometric parameters of the complexes were determined using uv-vis spectroscopy and dft calculations. the analyses of homo and lumo have been used to explain the charge transfer within the molecule. antimicrobial ...201728546116
diversity and probiotic potential of lactic acid bacteria isolated from horreh, a traditional iranian fermented food.the aim of this study was to evaluate the probiotic potential of lactic acid bacteria (lab) strains isolated from horreh. some probiotic properties, e.g., resistance to acid, bile tolerance, antibacterial activity, and antibiotic susceptibility, were investigated. a total of 140 gram-positive and catalase-negative isolates from horreh were subjected to identification and grouping by cultural methods and the 16s rrna sequencing. the new isolates were identified to be lactobacillus (fermentum, pla ...201728527125
release study and inhibitory activity of thyme essential oil-loaded chitosan nanoparticles and nanocapsules against foodborne bacteria.the antibacterial property of thyme essential oil due to different volatile compounds, has been well documented in the literature. to overcome the high volatility of essential oil components, encapsulation has emerged as a new alternative. in this work, chitosan and thyme essential oil-loaded chitosan nanoparticles (teo-csnps) and nanocapsules (teo-csncs) were prepared by nanoprecipitation and nanoencapsulation, respectively. the morphology, encapsulation efficiency, release kinetics, and inhibi ...201728526346
non-contact electromagnetic induction heating for eradicating bacteria and yeasts on biomaterials and possible relevance to orthopaedic implant infections: in vitro findings.infection of implants is a major problem in elective and trauma surgery. heating is an effective way to reduce the bacterial load in food preparation, and studies on hyperthermia treatment for cancer have shown that it is possible to heat metal objects with pulsed electromagnetic fields selectively (pemf), also known as induction heating. we therefore set out to answer the following research question: is non-contact induction heating of metallic implants effective in reducing bacterial load in v ...201728522446
cyclic diarylheptanoids from corylus avellana green leafy covers: determination of their absolute configurations and evaluation of their antioxidant and antimicrobial activities.the methanol extract of the leafy covers of corylus avellana, source of the italian pgi (protected geographical indication) product "nocciola di giffoni", afforded two new cyclic diarylheptanoids, giffonins t and u (2 and 3), along with two known cyclic diarylheptanoids, a quinic acid, flavonoid-, and citric acid derivatives. the structures of giffonins t and u were determined as highly hydroxylated cyclic diarylheptanoids by 1d and 2d nmr experiments. their relative configurations were assigned ...201728520428
antibacterial and antioxidative activity of o-amine functionalized chitosan.cinnamaldehyde was immobilized to o-amine functionalized chitosan via a coupling reaction. fourier transform infrared spectroscopy confirmed n-cinnamyl substitution. wetting analyses demonstrate more hydrophobicity in the n-cinnamyl substituted o-amine functionalized chitosan compared to chitosan or unsubstituted o-amine functionalized chitosan. thermal gravimetric analysis and differential scanning calorimetry demonstrates that the prepared n-cinnamyl substituted o-amine functionalized chitosan ...201728504167
green synthesis, characterisation and bioactivity of plant-mediated silver nanoparticles using decalepis hamiltonii root extract.consistent search of plants for green synthesis of silver nanoparticles (snps) is an important arena in nanomedicine. this study focuses on synthesis of snps using bioreduction of silver nitrate (agno3) by aqueous root extract of decalepis hamiltonii. the biosynthesis of snps was monitored by uv-vis analysis at absorbance maxima 432 nm. the fluorescence emission spectra of snps illustrated the broad emission peak 450-483 nm at different excitation wavelengths. the surface characteristics were st ...201728476981
self assembled snowball-like hybrid nanostructures comprising viburnum opulus l. extract and metal ions for antimicrobial and catalytic applications.herein, we report the production of novel organic-inorganic nanobio-catalytic and antimicrobial agents called "nanosnowball" (nsbs) with a rational design and elucidate the increase in the catalytic and antimicrobial activities. the nsbs resemble to guelder rose were formed of the extract of viburnum opulus (vo) as the organic component and copper (ii) ions (cu(2+)) as the inorganic component. the effects of the vo extract and cu(2+) concentrations on the morphology of nsbs were systematically e ...201728465062
epidemiological study of common diseases and their risk factors in camels in south punjab, pakistan.bacteriological study of mastitis along with common blood protozoan diseases were studied in dromedary camels in cholistan, dera ismail khan and rahim yar khan districts in south punjab, pakistan. for this purpose 300 camels were sampled randomly at different common grazing and watering point. for study of blood parasites clinically suspected and apparently healthy camels, 150 each, were sampled. an overall prevalence of 15%and 5% was recorded for trypanosomiasis and anaplasmosis respectively. t ...201728428133
production and characterization of curcumin microcrystals and evaluation of the antimicrobial and sensory aspects in minimally processed carrots.nontoxic conserving agents are in demand by the food industry due to consumers concern about synthetic conservatives, especially in minimally processed food. the antimicrobial activity of curcumin, a natural phenolic compound, has been extensively investigated but hydrophobicity is an issue when applying curcumin to foodstuff. the objective of this work was to evaluate curcumin microcrystals as an antimicrobial agent in minimally processed carrots. the antimicrobial activity of curcumin microcry ...201728406506
analysis of kudoa septempunctata as a cause of foodborne illness and its associated differential diagnosis.recently kudoa septempuctata in olive flounders is suggested as a cause of food poisoning, however whether kudoa septempuctata can affect human gastrointestinal systems is controversial and its pathogenecity remains unclear. in view of the field epidemiology, food poisonings caused by kudoa septempuctata should be distinguished from those caused by staphylococcus aureus and bacillus cereus.201728395399
antibacterial and antibiotic potentiating activities of tropical marine sponge extracts.increasing prevalence of antibiotic resistance has led research to focus on discovering new antimicrobial agents derived from the marine biome. although ample studies have investigated sponges for their bioactive metabolites with promising prospects in drug discovery, the potentiating effects of sponge extracts on antibiotics still remains to be expounded. the present study aimed to investigate the antibacterial capacity of seven tropical sponges collected from mauritian waters and their modulat ...201728392375
use of whey as a culture medium for bacillus clausii for the production of protein hydrolysates with antimicrobial and antioxidant activity.the use of whey as a natural culture medium to produce hydrolysates with antimicrobial from bacillus clausii is the objective of this research. the fermentation process was carried out at 25 ℃ for five days, where proteolytic activity, soluble peptides quantification, and antimicrobial activity using the disc diffusion method were determined every day. the fermented whey reached values ​​of proteolytic activity between 90 and 260 u ml(-1) and a production of soluble peptides between 100 and 2070 ...201728816527
utilization of industrial waste for the production of bio-preservative from bacillus licheniformis me1 and its application in milk and milk-based food products.the bio-preservative efficacy of a partially purified antibacterial peptide (ppabp) produced by bacillus licheniformis me1 in an economical medium developed using agro-industry waste was evaluated by direct application in milk and milk-based food products. the addition of ppabp in milk samples stored at 4 ± 2 °c and 28 ± 2 °c resulted in the growth inhibition of pathogens listeria monocytogenes scott a, micrococcus luteus atcc 9341, and staphylococcus aureus fri 722. the shelf life of milk sampl ...201728842843
vendor effects on murine gut microbiota influence experimental abdominal sepsis.experimental animal models are indispensable components of preclinical sepsis research. reproducible results highly rely on defined and invariant baseline conditions. our hypothesis was that the murine gut microbiota varies among different distributors of laboratory animals and that these variations influence the phenotype of abdominal sepsis derived from a bacterial inoculum model (intraperitoneal stool injection).201728501108
molecular characterization and functional analysis of the hepcidin gene from roughskin sculpin (trachidermus fasciatus).hepcidin is a kind of cysteine-rich antimicrobial peptide that plays a vital role in host innate immune activity and iron regulation. here, we report the molecular characterization and functional analysis of a novel hamp1 hepcidin isoforms tf-hep from roughskin sculpin, trachidermus fasciatus. a cdna fragment of 988 bp with an orf of 273 bp was obtained. the coding sequence encodes for a signal peptide of 24 amino acids coupled with a prodomain of 40 amino acids and a mature peptide of 26 amino ...201728743631
ultraviolet/ultrasound-activated persulfate for degradation of drug by zinc selenide quantum dots: catalysis and microbiology study.in this study, wet chemical method used for znse quantum dots (qds) and characterized by, uv-vis, photoluminescence spectroscopy, x-ray diffraction and transmission electron microscopy. the crystallites size of znse qds was 4.0nm. the average diameters of znse qds were 3.0-5.3nm. ritalin was degraded using the uv/znse qds/persulfate process. the several parameters investigated for the influence of rtialin degradation were the temperature, the persulfate concentration, and the initial ritalin con ...201728475974
inactivation of pathogenic microorganisms in freshwater using hso5(-)/uv-a led and hso5(-)/m(n+)/uv-a led oxidation processes.freshwater disinfection using photolytic and catalytic activation of peroxymonosulphate (pms) through pms/uv-a led and pms/m(n+)/uv-a led [m(n+) = fe(2+) or co(2+)] processes was evaluated through the inactivation of three different bacteria: escherichia coli (gram-negative), bacillus mycoides (sporulated gram-positive), staphylococcus aureus (non-sporulated gram-positive), and the fungus candida albicans. photolytic and catalytic activation of pms were effective in the total inactivation of the ...201728651081
lactolisterin bu, a novel class ii broad spectrum bacteriocin from lactococcus lactis subsp. lactis bv. diacetylactis bgbu1-4.lactococcus lactis subsp. lactis bv. diacetylactis bgbu1-4 produces a novel bacteriocin, lactolisterin bu, with strong antimicrobial activity against many species of gram-positive bacteria, including important food spoilage and food-borne pathogens such as listeria monocytogenes, staphylococcus aureus, bacillus sp. and streptococci. lactolisterin bu was extracted from the cell surface of bgbu1-4 by propan-2-ol and purified to homogeneity by c18 solid phase extraction and reversed phase hplc. the ...201728842543
enhancing antidiabetic and antimicrobial performance of ocimum basilicum, and ocimum sanctum (l.) using silver nanoparticles.the role of silver nanoparticles (agnps) is an attractive proposition for advancing modern diabetes therapies and applied science. stable agnps with a size range of 3-25 nm were synthesized using aqueous leaf extracts from ocimum basilicum, ocimum sanctum, and in combination. the concentration of the extracts facilitated the reduction of silver nitrate that led to the rapid formation of agnps at room temperature, indicating a higher reaction rate as opposed to harsh chemical methods, and high co ...201728855825
a proteomic signature of dormancy in the actinobacterium micrococcus luteus.dormancy is a protective state in which diverse bacteria, including mycobacterium tuberculosis, staphylococcus aureus, treponema pallidum (syphilis), and borrelia burgdorferi (lyme disease), curtail metabolic activity to survive external stresses, including antibiotics. evidence suggests dormancy consists of a continuum of interrelated states, including viable but nonculturable (vbnc) and persistence states. vbnc and persistence contribute to antibiotic tolerance, reemergence from latent infecti ...201728484042
structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation.hydrogen sulfide (h2s) is a signaling molecule that is toxic at elevated concentrations. in eukaryotes, it is cleared via a mitochondrial sulfide oxidation pathway, which comprises sulfide quinone oxidoreductase, persulfide dioxygenase (pdo), rhodanese, and sulfite oxidase and converts h2s to thiosulfate and sulfate. natural fusions between the non-heme iron containing pdo and rhodanese, a thiol sulfurtransferase, exist in some bacteria. however, little is known about the role of the pdo-rhodane ...201728684420
pre-banking microbial contamination of donor conjunctiva and storage medium for penetrating keratoplasty.the aims of this study were to investigate the incidence of positive donor tissue cultures before transfer to preservation medium (optisol™-gs) for penetrating keratoplasty, to verify the efficacy of antibiotics contained in optisol™-gs by examining the drug susceptibility and to assess the relationship between the results of our microbial assessments as well as donor factors and the incidence of contamination.201728597192
multidrug resistant bacteria are sensitive to euphorbia prostrata and six others cameroonian medicinal plants extracts.multidrug resistant (mdr) bacteria are responsible for therapeutic failure and there is an urgent need for novels compounds efficient on them.201728743314
development of an isothermal amplification-based assay for the rapid visual detection of salmonella bacteria.the efficient and timely detection of pathogens is a major concern worldwide. the aim of this study was to establish a rapid detection method for salmonella bacteria in food samples to facilitate timely treatment. widely used detection methods currently include culture-based methods and pcr-based methods. the former are time consuming, requiring 2 to 3 d, whereas the latter have higher accuracy but are typically complicated, requiring expertise and expensive instruments. in this study, a sensiti ...201728711269
a rapid salmonella detection method involving thermophilic helicase-dependent amplification and a lateral flow assay.salmonella is a major foodborne pathogen that is widespread in the environment and can cause serious human and animal disease. since conventional culture methods to detect salmonella are time-consuming and laborious, rapid and accurate techniques to detect this pathogen are critically important for food safety and diagnosing foodborne illness. in this study, we developed a rapid, simple and portable salmonella detection strategy that combines thermophilic helicase-dependent amplification (thda) ...201728526589
[effects of vacuum sealing drainage technique in acute and chronic suppurative tenosynovitis of hand].objective: to investigate the effects of vacuum sealing drainage technique in acute and chronic suppurative tenosynovitis of hand. methods: a total of 9 cases acute and chronic suppurative tenosynovitis patients from january 2013 to april 2015 in puai hospital affiliated to tongji medical college, huazhong university of science and technology were retrospectively reviewed. there were 6 males and 3 females, aging from 27 to 65 years, the average age was 55 years. there were 3 cases of index finge ...201728464581
a comparative study of oral microbiota in infants with complete cleft lip and palate or cleft soft palate.few reports have been published on the early microbiota in infants with various types of cleft palate. we assessed the formation of the oral microbiota in infants with complete cleft lip and palate (clp n = 30) or cleft soft palate (csp n = 25) in the neonatal period (t1 time) and again in the gum pad stage (t2 time). culture swabs from the tongue, palate, and/or cleft margin at t1 and t2 were taken. we analysed the prevalence of the given bacterial species (the percentage) and the proportions i ...201728393073
evidence for the evolutionary steps leading to meca-mediated β-lactam resistance in staphylococci.the epidemiologically most important mechanism of antibiotic resistance in staphylococcus aureus is associated with meca-an acquired gene encoding an extra penicillin-binding protein (pbp2a) with low affinity to virtually all β-lactams. the introduction of meca into the s. aureus chromosome has led to the emergence of methicillin-resistant s. aureus (mrsa) pandemics, responsible for high rates of mortality worldwide. nonetheless, little is known regarding the origin and evolution of meca. differ ...201728394942
bacterial prevalence and antibiotic resistance in clinical isolates of diabetic foot ulcers in the northeast of tamaulipas, mexico.diabetic foot ulcers (dfus) are a serious and common problem in patients with diabetes mellitus and constitute one of the major causes of lower extremity amputation. the microbiological profile of dfus depends on the acute or chronic character of the wound. aerobic gram-positive cocci are the predominant organisms isolated from dfus. diabetic foot biopsies from patients admitted to the angiology and vascular surgery hospital of the northeast, in reynosa, tamaulipas from december 2011 to april 20 ...201728682727
isolation and characterization of lactic acid bacteria from traditional pickles of himachal pradesh, india.a total of 15 isolates of lactic acid bacteria (lab) were isolated from traditional pickles of rural and urban areas of himachal pradesh. these isolates were identified as enterococcus faecalis (7), lactobacillus plantarum (3), pediococcus pentosaceus (2), leuconostoc mesenteroides (1), lactococcus lactis (1) and enterococcus sp. (1) on the basis of morphological, biochemical and 16s rdna sequence analysis. all the labs produced exopolysaccharides, have antibiotic susceptibility, and possess act ...201728720951
characterization and bioactivities of the exopolysaccharide from a probiotic strain of lactobacillus plantarum wlpl04.exopolysaccharide (eps) was extracted and purified from lactobacillus plantarum wlpl04, which has been confirmed previously as a potential probiotic for its antagonistic and immune-modulating activity. it has a molecular weight of 6.61 × 10(4) da, consisting of xylose, glucose, and galactose in an approximate molar ratio of 3.4: 1.8: 1. microstructural studies demonstrated that the eps appeared as a smooth sheet structure with many homogeneous rod-shaped lumps. the preliminary in vitro assays in ...201728711240
urea-derived graphitic carbon nitride (u-g-c3n4) films with highly enhanced antimicrobial and sporicidal activity.in this manuscript, we describe the fabrication of photoactive biocidal or sporicidal films from urea-derived graphitic carbon nitride (u-g-c3n4). co-deposited films of u-g-c3n4 and escherichia coli o157:h7 (ic50=14.1±0.2mj) or staphylococcus aureus (methicillin resistant ic50=33.5±0.2mj, methicillin sensitive ic50=42.7±0.5mj) demonstrated significantly enhanced bactericidal behavior upon administration of visible radiation (400nm≤λ≤426nm). in all cases, complete eradication of the microbial sam ...201728675870
impacts of pulsed electric field and heat treatment on quality and sensory properties and microbial inactivation of pomegranate juice.synergistic effects of pulsed electric field+mild heat on quality properties of pomegranate juice were modeled using the best-fit multiple (non-) linear regression models with inactivation kinetics parameters of escherichia coli o157:h7 and staphylococcus aureus. no significant difference was detected between the control and the treated samples in terms of ph; °brix; total antioxidant capacity; total monomeric anthocyanin content; total ascorbic acid concentration; and the sensory properties of ...201728610446
sensitive detection of staphylococcus aureus with vancomycin-conjugated magnetic beads as enrichment carriers combined with flow cytometry.a novel sandwich strategy was designed to detect staphylococcus aureus. the strategy is based on an antibacterial agent that captures bacterial cells and a fluorescein-labeled antibody that acts as the signal-output probe. vancomycin (van), which exerts a strong antibacterial effect on gram-positive bacteria, was utilized as a molecular recognition agent to detect pathogenic bacteria. to effectively concentrate s. aureus, we used bovine serum albumin (bsa) as the amplification carrier to modify ...201728590745
bactericidal effect of 266 to 279nm wavelength uvc-leds for inactivation of gram positive and gram negative foodborne pathogenic bacteria and yeasts.recently, uvc-led technology has been validated as an alternative to irradiation with conventional mercury uv lamps. in this study, we sought to determine primary factors affecting reduction trends shown in several microorganisms. four major foodborne pathogens (escherichia coli o157:h7, salmonella spp. listeria monocytogenes, staphylococcus aureus) and spoilage yeasts (saccharomyces pastorianus, pichia membranaefaciens), important to the brewing industry, were inoculated onto selective and non- ...201728578053
silver nanoparticles: antimicrobial activity, cytotoxicity, and synergism with n-acetyl cysteine.the fast progression of nanotechnology has led to novel therapeutic interventions. antimicrobial activities of silver nanoparticles (ag nps) were tested against standard atcc strains of staphylococcus aureus (atcc 9144), escherichia coli (o157:h7), pseudomonas aeruginosa (atcc 27853), and candida albicans (atcc 90028) in addition to 60 clinical isolates collected from cancer patients. antimicrobial activity was tested by disk diffusion method and mic values for ag nps alone and in combination wi ...201728543603
production and characterization of a new biodegradable fenugreek seed gum based active nanocomposite film reinforced with nanoclays.in the present work, fenugreek seed gum (fsg)/clay nanocomposite films were prepared with nanoclays (na(+) montmorillonite [mmt], halloysite [hnt] and nanomer(®) i.44 p [nm]) at different amounts (0, 2.5, 5.0 and 7.5g clay/100g fsg) by solution casting method and characterized. increasing amount of nanoclay significantly (p<0.05) improved oxygen barrier and thermal properties of the biodegradable films. agar diffusion tests revealed that fsg based nanocomposite films exhibited strong antimicrobi ...201728536016
[synthesis of antibiotic loaded polylactic acid nanoparticles and their antibacterial activity against escherichia coli o157:h7 and methicillin-resistant staphylococcus aureus].polymeric nanoparticles are promising nanotechnology tools to fight pathogenic bacteria resistant to conventional antibiotics.201728527243
efficacy of (+)-lariciresinol to control bacterial growth of staphylococcus aureus and escherichia coli o157:h7.this study was undertaken to assess the antibacterial potential of a polyphenolic compound (+)-lariciresinol isolated from rubia philippinensis against selected foodborne pathogens staphylococcus aureus kctc1621 and escherichia coli o157:h7. (+)-lariciresinol at the tested concentrations (250 μg/disk) evoked a significant antibacterial effect as a diameter of inhibition zones (12.1-14.9 mm) with minimum inhibitory concentration (mic), and minimum bactericidal concentration values of 125-250 and ...201728515721
development of a gold nanoparticle-based universal oligonucleotide microarray for multiplex and low-cost detection of foodborne pathogens.bacterial foodborne diseases remain major threats to food safety and public health, especially in developing countries. in this study a novel assay, combining gold nanoparticle (gnp)-based multiplex oligonucleotide ligation-pcr and universal oligonucleotide microarray technology, was developed for inexpensive, specific, sensitive, and multiplex detection of eight common foodborne pathogens, including shigella spp., campylobacter jejuni, bacillus cereus, escherichia coli o157:h7, listeria monocyt ...201728505584
development of gold nanoparticles coated with silica containing the antibiofilm drug cinnamaldehyde and their effects on pathogenic bacteria.emerging resistance to antibiotics is a mounting worldwide health concern and increases the need for nonantibiotic strategies to combat infectious diseases caused by bacterial pathogens. in this study, the authors used the antibiofilm activity of the naturally occurring antimicrobial cinnamaldehyde (cnma) conjugated to the surface of gold nanoparticles (gnps) to deliver cnma efficiently and eradicate biofilms of gram-negative organisms (enterohemorrhagic escherichia coli o157:h7, and pseudomonas ...201728435260
antibacterial action of jineol isolated from scolopendra subspinipes mutilans against selected foodborne pathogens.this study was undertaken to assess the antibacterial potential of 3,8-dihydroxyquinoline (jineol) isolated from scolopendra subspinipes mutilans against selected foodborne pathogens escherichia coli o157:h7 and staphylococcus aureus kctc-1621. jineol at the tested concentration (50 μl; corresponding to 250 μg/disk) exhibited significant antibacterial effects as a diameter of inhibition zones (11.6-13.6 mm), along with minimum inhibitory concentration (mic) and minimum bactericidal concentration ...201728400770
risk of cardiac pacemaker pocket infection in a tertiary care hospital.the risk of pacemaker pocket infections (ppis) is rare with good antisepsis techniques and use of advanced antibiotics. however, injudicious antibiotic usage leads to the rise of multidrug-resistant bacteria, which may cause ppi. few reports exist about the microbial spectrum of the ppi from our country, prompting us to study the same.201728631632
reduction of reactive red 241 by oxygen insensitive azoreductase purified from a novel strain staphylococcus ku898286.an oxygen insensitive azoreductase was purified from a novel bacterial strain (staphylococcus sp. ku898286) that was isolated from an abandoned site of the textile waste discharge unit. the isolated enzyme had efficiently cleaved the azo-bonds through reductive transformation under aerobic conditions. initial phenotypic characterization and final construction of phylogenetic tree on the basis of 16s rdna demonstrated 99% resemblance of the isolate to staphylococcus aureus. the purified azoreduct ...201728467413
endogenous bacterial endophthalmitis. a report of 2cases.the cases are presented on 2patients with bacterial endogenous endophthalmitis. the first one was caused by streptococcus bovis, developed after colonoscopy, which had a poor outcome and resulted in evisceration. the second case was caused by a methicillin resistant staphylococcus aureus from an arthrodesis complicated with a para-spinal abscess. it had an excellent visual outcome.201728427732
[brain abscess in children: ten years of experience in a third level pediatric hospital].brain abscess is a focal infection that occurs with a frequency of 0.3-1.3 cases per 100,000 people/year. we describe the epidemiology, clinical and microbiology characteristics of 38 children diagnosed with brain abscess hospitalized between 4/1/2005 and 12/31/2015 at hospital de pediatría "prof. dr. juan p. garrahan" in buenos aires city. twenty-four patients were male. the median age was 132 months. predisposing factors were detected in 25 children. the median evolution from onset of symptoms ...201728737874
update on the epidemiology and antibiotic resistance of ocular infections.the purpose of this review is to provide an update on the epidemiology and current antibiotic-resistant threats in ophthalmology.201728546690
the changing epidemiology and clinical features of infective endocarditis: a retrospective study of 196 episodes in a teaching hospital in china.infective endocarditis is an uncommon but life-threatening infectious disease. to our knowledge, current investigations of the characteristics of infective endocarditis in our region are scarce. in this study, we aimed to investigate the changes in the epidemiology and clinical features of infective endocarditis.201728482820
bacterial and histopathological findings in deep head and neck infections: a retrospective analysis.deep neck infections are among the most dangerous acute diseases in the head and neck region. this analysis gives an overview of the bacterial and histopathologic findings of deep neck infections.201728411005
derivatives of holomycin and cyclopropaneacetic acid from streptomyces sp. dt-a37.on the basis of the one strain-many compounds strategy, five compounds including two new holomycin derivatives 2 - 3, two new cyclopropaneacetic acid derivatives 4 - 5, together with one known compound holomycin (1) were isolated from a marine-derived bacterium streptomyces sp. dt-a37. their structures were elucidated using nmr and hr-esi-ms analyses. all these compounds were evaluated for their antimicrobial activity, cytotoxic activity, and inhibitory activity against brd4 protein. compound 1 ...201728627048
neo-actinomycins a and b, natural actinomycins bearing the 5h-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived streptomyces sp. imb094.neo-actinomycins a and b (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5h-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete streptomyces sp. imb094. their structures were elucidated by spectroscopic analyses. the presence of this ring system was proposed to originate from a condensation between actinomycin d (3) with α-ketoglutarate and pyruvate, respectively. compound 1 showed potent cytotoxic activities against human canc ...201728620204
bioactive bafilomycins and a new n-arylpyrazinone derivative from marine-derived streptomyces sp. hzp-2216e.a meoh extract prepared from culture of an actinomycete streptomyces sp. hzp-2216e isolated from marine green algae ulva pertusa was found to significantly inhibit proliferation of human glioma cells. two different media were applied to culture this marine actinomycete, which produced two new compounds of 23-o-butyrylbafilomycin d and streptoarylpyrazinone a, together with known bafilomycin d, 9-hydroxybafilomycin d, and bafilomycin a1. structures of new compounds were determined by extensive nm ...201728571080
chalcomycins from marine-derived streptomyces sp. and their antimicrobial activities.dihydrochalcomycin (1) and chalcomycin, (2), two known chalcomycins, and chalcomycin e (3), a new compound, were isolated from marine-derived streptomyces sp. hk-2006-1. their structures were elucidated by detailed spectroscopic and x-ray crystallographic analysis. the antimicrobial activities against staphylococcus aureus, escherichia coli, candida albicans, and aspergillus niger of 1-3 were evaluated. compounds 1-2 exhibited activities against s. aureus with minimal inhibitory concentrations ( ...201728555051
isolation, purification, and characterization of five active diketopiperazine derivatives from endophytic streptomyces suk 25 with antimicrobial and cytotoxic activities.in our search for new sources of bioactive secondary metabolites from streptomyces sp., the ethyl acetate extracts from endophytic streptomyces suk 25 afforded five active diketopiperazine (dkp) compounds. the aim of this study was to characterize the bioactive compounds isolated from endophytic streptomyces suk 25 and evaluate their bioactivity against multiple drug resistance (mdr) bacteria such as enterococcus raffinosus, staphylococcus aureus, klebsiella pneumoniae, acinetobacter baumanii, p ...201728535606
lobophorin k, a new natural product with cytotoxic activity produced by streptomyces sp. m-207 associated with the deep-sea coral lophelia pertusa.the present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin k (1), from cultures of the marine actinobacteria streptomyces sp. m-207, previously isolated from the cold-water coral lophelia pertusa collected at 1800 m depth during an expedition to the submarine avilés canyon. its structure was determined using a combination of spectroscopic techniques, mainly esi-tof ms and 1d and 2d nmr. this new natural product displayed cytotoxic acti ...201728534807
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