Publications

morphometric analysis of the cell outlines of normal and polyomavirus-transformed fr 3t3 fibroblasts.	a method is described for the analysis of cell shape, using an image analyzer connected to a computer to assess the cell outline. a series of parameters to assess the contribution of large cytoplasmic expansions to cell morphology and to cell spreading on a planar substratum were used to quantify the visual morphologic differences between normal (nontransformed; n.3t3) and polyomavirus-transformed (py.3t3) fisher rat 3t3 fibroblasts. the results show that the py.3t3 fibroblasts are more spherica ...	1987	2822058
presynaptic opioid kappa-receptor and regulation of the release of met-enkephalin in the rat brainstem.	opioid kappa-agonists had much more potent inhibitory effects on the high k+-evoked met-enkephalin release from rat brain slices than did the mu- or delta-agonists. the opioid kappa- antagonist, mr2266 enhanced the evoked release of met-enkephalin to a greater extent than did mu- or delta-antagonists in vitro and had a potent analgesia in mice in vivo. these findings suggest that the release of met-enkephalin may be regulated in vitro and in vivo, mainly by presynaptic kappa-receptor-mediated me ...	1987	2829060
[cigarette smoking and lung metabolism--effects of cigarette smoking on plasma levels of complement c3a and c5a in rabbits].		1987	3500346
the kappa agonists pd117302 and u50488 produce a biphasic effect on 24 hour food intake in the rat.	the effects of the selective kappa opioid receptor agonists pd117302 [(+/-)trans-n-methyl-n-[2-(1-pyrrolidinyl)-cyclohexyl-]benzo-[b]- thiophene-4-acetamide] and u50488 (trans-3,4-dichloro-n-methyl-n-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide) were investigated on food intake in non-deprived rats over a 24 hr period following subcutaneous administration. at doses of 2.5 mg/kg and 5 mg/kg, both pd117302 and u50488 initially increased food intake. between 6-24 hr, however, pd117302 (2.5-10 ...	1987	2829048
subfractionation of human t lymphocyte subpopulations by partitioning: surface heterogeneity of the okt8/leu2+ t cell subset.	human peripheral blood mononuclear cells (pbmc) were subjected to countercurrent distribution in a charge-sensitive dextran-poly (ethylene glycol) aqueous two-phase system. cells are thereby subfractionated on the basis of their charge-associated surface properties. the helper/inducer t cell subset (okt4/leu3+) has a single distribution curve with a low partition ratio (p). in contrast, the suppressor/cytotoxic (okt8/leu2+) subset is clearly heterogeneous and gives two peaks, one with a lower an ...	1987	2955975
chronic cardiac toxicity after inhalation of 1,1,1-trichloroethane.	two patients showed evidence of chronic cardiac toxicity after repeated exposure to 1,1,1-trichloroethane. in both cases there was circumstantial evidence of a deterioration after routine anaesthetic use of the related compound halothane. an adolescent boy who sniffed trichloroethane presented with multiple ventricular arrhythmias during tonsillectomy. follow up showed mild chronic left ventricular impairment. a 54 year old man had repeated industrial exposure to trichloroethane and deteriorated ...	1987	3105712
chronic cardiac toxicity after inhalation of 1,1,1-trichloroethane.	two patients showed evidence of chronic cardiac toxicity after repeated exposure to 1,1,1-trichloroethane. in both cases there was circumstantial evidence of a deterioration after routine anaesthetic use of the related compound halothane. an adolescent boy who sniffed trichloroethane presented with multiple ventricular arrhythmias during tonsillectomy. follow up showed mild chronic left ventricular impairment. a 54 year old man had repeated industrial exposure to trichloroethane and deteriorated ...	1987	3105712
renal functional changes after converting enzyme inhibition or nitroprusside in hypertensive rats.		1987	3038467
the leeuwenhoek lecture, 1986. environmental carcinogens and papillomaviruses in the pathogenesis of cancer.	in many areas of the world there is a geographically localized high incidence of alimentary and bladder cancer in cattle. studies in western scotland have demonstrated that this phenomenon is associated with ingestion of bracken fern. however, the affected animals and herds were shown also to have an unusually high infection rate of alimentary papillomas caused by a previously unrecognised bovine papillomavirus (bpv) and that these tumors could undergo malignant transformation. long-term field a ...	1987	2888116
high rate of plasmodium vivax relapse following treatment of falciparum malaria in thailand.	within two months of treatment for falciparum malaria, plasmodium vivax infections developed in 58 (33%) of 174 patients who had received a quinine or quinidine regimen and in 46 (32%) of 145 patients who had received mefloquine with inpatient follow-up of more than six weeks. the time to vivax relapse was significantly longer after mefloquine treatment (median 47 days, range 30-65) than after quinine or quinidine treatment (21 days, 15-36; p less than 0.0001). all patients remained outside area ...	1987	2889965
reinfection of guinea pigs with herpes simplex virus type 2: failure to establish a second latent ganglionic infection.	guinea pigs were infected with herpes simplex virus type 2 (hsv 2) and at various times thereafter reinfected at a different site with the same or a different strain of hsv 2. viruses were isolated from infected tissues either from the site of primary or secondary infection or from regional ganglia. viral isolates were characterised by dna fingerprinting using restriction endonucleases capable of differentiating between the virus strains used. the second infection resulted in a second site of pe ...	1987	2825951
molecular nature of a cell membrane antigen specific for human t-cell acute lymphoblastic leukemia.	in the present work, we characterized the molecular nature of a t-cell acute lymphoblastic leukemia (t all) specific antigen, termed talla, which is defined by monoclonal antibody sn1. sn1 shows an extremely high specificity for t all. in the present study, sn1 was further shown not to react significantly with various normal solid tissues. talla was determined to be a glycoprotein with an approximate molecular weight of 150,000. however, the molecular nature of talla is peculiar in that heating ...	1987	2440562
secretagogue-induced changes in intracellular ph and amylase release in mouse pancreatic acini.	the response of the intracellular ph (phi) to stimulation of enzyme secretion in pancreatic acini was measured using the fluorescent dye 2'-7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. acini suspended in ph 7.40 buffer demonstrated cytoplasmic alkalinization of 0.17, 0.14, and 0.15 ph units 2 min after addition of the secretagogues carbachol (10(-5) m), caerulein (10(-10) m), and bromo-a23187 (10(-6) m). corresponding net stimulated amylase secretion over 30 min was 9.2, 10.3, and 5.6% of total ...	1987	2446509
unusual association of bone marrow necrosis, disseminated intravascular coagulation, and a rare 8;16 chromosomal translocation in an adult patient with acute nonlymphocytic leukemia.	in a patient with acute nonlymphocytic leukemia of the classic type (fab subtype m2), three infrequently observed phenomena occurred together; bone marrow necrosis, disseminated intravascular coagulation, and an 8;16 chromosomal translocation. all three resolved with antileukemic therapy, only to reemerge when the leukemia relapsed, suggesting a causal relationship among these phenomena. such observations and the consistent application of cytogenetic studies to patients with leukemia may help el ...	1987	3791177
cardiovascular response to sudden strenuous exercise.	cardiac responses to sudden strenuous exercise were studied in seven dogs instrumented to measure cardiac output (q), stroke volume (sv), left ventricular (lv) pressure, aortic pressure and circumflex coronary blood flow (cbf). the dogs were run on a treadmill at 12.9 km/h, 20% grade for 15s without prior warm-up. during the first 10s of the run, hr and q increased rapidly. by 2s, myocardial o2 requirements, as estimated from either the tension time index (tti) or calculated wall tension, had in ...	1987	3632566
immunization with heat-killed pneumococci, but not pneumococcal capsular polysaccharides, improves survival in splenectomized mice.	immunization with pneumococcal capsular polysaccharides (pn ps) is advocated after splenectomy to decrease the risk of overwhelming sepsis. the clinical and experimental evidence for the benefit of immunization after splenectomy is controversial. various reports in the literature have claimed a benefit of immunization after splenectomy, but careful review of methodologies reveals that heat-killed pneumococci (pn) were used to immunize the experimental animals. since we have not been able to prot ...	1987	3807350
[screening and other alternatives in the fight against hiv].		1987	3424318
[the effect of neythumun in comparison with 2-cyanoethylurea on the white blood count of the rat].	the stimulation effect of neythymun-sol f+k (nthy) and 2-cyanethylcarbamide (cec) on the leucocytopoesis was studied in 30 wistar rats and a moderate but significant increase in the total number of leucocytes was found. the increase produced by cec didn't prove significantly higher than that by nthy. after 32 d the blood count showed a substantial difference concerning the neutrophils with an increase from 3000 to 9000 without deviation to the left, which was found only under neythymun. this com ...	1986	3797457
influence of single neonatal treatment with allylestrenol or diethylstilbestrol on microsomal enzyme activity of rat liver in adulthood.	a single neonatal treatment of rats with a steroid (allylestrenol or diethylstilbestrol) did not alter the later activity of the hepatic microsomal (cytochrome p-450) enzyme system, but inhibited the inducer action of another steroid (testosterone) administered at the age of six weeks. this suggests that a hormonal imprinting-like mechanism also operates in the case of enzymes.	1986	3784633
influence of single neonatal treatment with allylestrenol or diethylstilbestrol on microsomal enzyme activity of rat liver in adulthood.	a single neonatal treatment of rats with a steroid (allylestrenol or diethylstilbestrol) did not alter the later activity of the hepatic microsomal (cytochrome p-450) enzyme system, but inhibited the inducer action of another steroid (testosterone) administered at the age of six weeks. this suggests that a hormonal imprinting-like mechanism also operates in the case of enzymes.	1986	3784633
[detection of the thyrostatic drug methylthiouracil (mtu) using high performance liquid chromatography (hplc) and high performance thin layer chromatography in tissues and tissue extracts of fattening cattle].		1986	3775348
effect of sodium pentobarbital on behavioral thermoregulation in rats and mice.	in this study on behavioral thermoregulation, male sprague-dawley rats were given intraperitoneal (ip) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male cba/j mice were given doses of 0, 5, 10, 15 or 30 mg/kg. the animals were immediately placed in a temperature gradient which allowed them to select their preferred ambient temperature (ta). the preferred ta of rats increased following an injection of 10 mg/kg sodium pentobarbital, whereas, the barbiturate had no eff ...	1986	3754969
promoting informed consent of women in labor.	laboring women are increasingly being asked to participate in perinatal research. these women should be considered captive or special subjects who deserve greater protection of their rights. essential elements of informed consent are reviewed. specific guidelines are suggested for promoting informed consent for women in labor participating in clinical research.	1986	3639933
influence of mouse genotype on responses of central biogenic amines to alcohol intoxication and aging.	dopamine and serotonin responses to various periods of alcohol treatment have been followed in striatum and hippocampus of two inbred strains of mice and related to the effect of aging. a striking strain dependency was noted for chronic alcohol effects and also for senescence. for both neurotransmitters studied the c57bl strain loses tolerance to prolonged alcohol injury earlier than the balb/c strain. this loss of tolerance accompanying aging may be indicative of more widespread changes in cns ...	1986	3814344
dose-related effects of synthetic human beta-endorphin and naloxone on fed gastrointestinal motility.	in humans, plasma beta-endorphin levels rise during application of acute stressful stimuli (vertigo, cold pain, and transcutaneous electrical stimulation) that induce gut motor disturbances. whereas it is possible that circulating beta-endorphin participates in the mediation of these central effects on gut motility, its role cannot be established solely on the basis of changes in plasma levels. therefore, we designed the present study to investigate 1) the dose-related effects of intravenous syn ...	1986	2942039
structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model.	physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ...	1986	2946570
structure-activity relationships of sex steroid analogs determined in vitro in a thyroid hormone-responsive membrane ca2+-atpase model.	physiological concentrations of l-t4 were found previously to stimulate ca2+-atpase activity in vitro in reticulocyte membranes from female rabbits and to inhibit this enzyme in reticulocyte membranes from males. in these previous studies, preincubation of intact cells or ghosts with testosterone (5 x 10(-11) m) converted female-source reticulocyte membranes to male-type responsiveness to thyroid hormone (inhibition of ca2+-atpase activity). preincubation of reticulocyte membranes with 17 beta-e ...	1986	2946570
cellular distribution of lysosomal hydrolase activities in the regenerating rat liver.	cathepsins b and d, beta-galactosidase, and acid phosphatase activities were found to be decreased in the regenerating rat liver, the reduction being maximal around the peak of hepatocyte mitoses (30 h). to investigate whether these changes could be heterogeneously distributed among hepatic cells, total cell populations from control or two-thirds hepatectomized rat livers were dissociated by the collagenase perfusion technique and analysed by different procedures. isopycnic centrifugation in a m ...	1986	3089641
[requirement of cyclic 3',5'-monophosphate in the production of a permeability increasing factor by vibrio cholerae].		1986	3018312
physiology and pathophysiology of the colonic circulation.	there is growing evidence that colonic blood flow is controlled by both intrinsic and extrinsic factors. the existence of intrinsic vascular control mechanisms is evidenced by pressure-flow (and oxygen uptake) autoregulation, reactive hyperemia, vascular responses to acute venous hypertension, and a functional hyperemia. although myogenic factors have long been considered to be solely responsible for the intrinsic ability of the colon to regulate its blood flow, recent developments indicate that ...	1986	3536216
a common mechanism of chromosomal translocation in t- and b-cell neoplasia.	the chromosomal breakpoint involved in the t(8;14)(q24;q11) chromosome translocation in the skw-3 cell line, which directly involves the 3' flanking region of the c-myc gene, was cloned and sequenced. the breakpoint on chromosome 8 mapped to a position 3 kb 3' of c-myc while the chromosome 14 breakpoint occurred 36 kb 5' of the gene for the constant region of the alpha chain of the t-cell receptor (tcr). the translocation resulted in a precise rearrangement of sequences on chromosome 8 and what ...	1986	3490692
hydatid disease: research and control in turkana. ii. the role of immunological techniques for the diagnosis of hydatid disease.	immunological studies have been applied to the immunodiagnosis of human hydatidosis in turkana and for the specific identification of echinococcus eggs, particularly in regard to their potential for the assessment of a hydatid control programme in the north-west of the district. a high rate of false negatives has been obtained with sensitive antibody tests for proven hydatid patients in turkana and presents problems for prevalence estimation in the population. a seroepidemiological study using s ...	1986	3787677
immunoelectrophoresis in quality control of veterinary clostridial products.	each year the pharmaceutical industry produces 150-250 batches of anti-clostridial vaccines and sera for veterinary use in the u.k. under medicines act requirements these products must be tested for potency before release to the public, such tests being performed in animals. the ministry of agriculture, as licensing authority, also carries out potency test on representative samples of these products. to avoid unnecessary use of animals we employ immunoelectrophoresis (iep) as a screening test. r ...	1986	3792642
[osmotic resistance of erythrocytes in cattle].		1986	3087113
effects of total parenteral nutrition on the development of intestinal endotoxemia in rats: a comparison between glucose and lipid.	the effects of parenteral nutrition (pn) and of the difference in the pn regimens between glucose and lipid emulsion on the development of endogenous endotoxemia were studied in 40 wister rats. endotoxemia was induced by occluding the superior mesenteric vein (smv) for 30 min. the plasma endotoxin in the portal blood at the time of the release of the smv occlusion and that in the arterial blood 10 min after the release were quantified. twenty of the 40 rats had received pn for 48 hr prior to the ...	1986	3091866
phosphoenolpyruvate carboxykinase as a selective indicator of ochratoxin a induced nephropathy.		1986	2881768
insulin stimulates cord blood erythroid progenitor growth: evidence for an aetiological role in neonatal polycythaemia.	polycythaemia in the neonate is a serious pathologic entity which occurs particularly in infants of diabetic mothers (idm) and small-for-gestational age (sga) infants. both of these conditions are associated with fetal hyperinsulinaemia. cultures of cord blood mononuclear cells from polycythaemic idm showed increased growth of late erythroid progenitor colonies, compared to cord blood mononuclear cells from non-polycythaemic infants, reflecting a possible expansion of this progenitor population ...	1986	3539174
[experimental hypovitaminosis d in guinea pigs administered different amounts of vitamin c].	the experimental model of d-hypovitaminosis is first obtained on guinea pigs. it is established that the least degree of its manifestation is determined under conditions of the optimal supply of the organism with vitamin c. the necessity of using ascorbic acid in a complex of rachitis prophylaxis measures is substantiated.	1986	3705209
fine structure of the organic matrix of human pancreatic stones.	pancreatic stones that were removed from the pancreatic ducts of patients with chronic calcifying pancreatitis were decalcified so the organic matrix could be studied by scanning and transmission electron microscopy. the observations made by scanning electron microscopy were compared with those made on undecalcified stones, and the findings were correlated with light microscopic observations. after the calcium carbonate was removed, the stones consisted of multiple partitions arranged like a spo ...	1986	3575306
relationships between pulmonary inflammation, plasma transudation, and oxygen metabolite secretion by alveolar macrophages.	we have previously shown that alveolar macrophages from normal rabbit lungs do not synthesize reactive oxygen intermediates unless first conditioned by culture in vitro in the presence of serum for 24 to 48 hr. this conditioning process is mediated by a serum constituent that partitions on gel exclusion columns with an apparent m.w. of 30,000 to 50,000 daltons. alveolar macrophage conditioning in vitro requires protein synthesis, is associated with the generation of membrane nadph oxidase activi ...	1986	3486910
[sequential histochemical studies of the esophageal carcinoma in rats induced by n-methyl-n-amylnitrosamine].		1985	4032830
tabulation and assessment of 113 human surveillance cytogenetic studies conducted between 1965 and 1984.	there is an increasing tendency to monitor human exposure to genotoxic chemicals by the assessment of chromosomal aberrations or sister-chromatid exchanges (sces) in peripheral blood lymphocytes. in order to assess the sensitivity of these techniques, and to discern minimal criteria for their conduct, a survey of 113 human lymphocyte cytogenetic surveillance studies conducted between 1965 and 1984 has been undertaken. the present survey indicates the urgent need for standardization of study prot ...	1985	4033683
copper deficiency in infants fed cow milk.		1985	3998919
identification of two cases of bovine undifferentiated tumours (squamous cell carcinoma and adenocarcinoma) by electron microscopy.	two cases of undifferentiated tumours were found in cows. electron microscopy revealed that one was an undifferentiated squamous cell carcinoma of unknown primary site and the other an undifferentiated adenocarcinoma of the lung.	1985	3837797
diversity and structure of genes of the alpha family of mouse t-cell antigen receptor.	we have analysed 19 complementary dna clones encoding the alpha-chain of the t-cell antigen receptor derived from thymic transcripts, and find that 15 of them contain partial or complete variable (v alpha) genes. seven of these genes cross-hybridize to over 40 germline v alpha gene segments in southern blot analyses. of the 19 joining (j alpha) sequences examined, 18 seem to be encoded by distinct gene segments, hence the repertoire of j alpha gene segments is much larger than those of the immun ...	1985	3839904
protein antigens of encapsulated klebsiella pneumoniae surface exposed after growth in the presence of subinhibitory concentrations of cephalosporins.	it recently has been reported by us that cephalosporins, at a concentration below that influencing growth rate, reduced the production of enterochelin and capsule formation of iron-depleted klebsiella pneumoniae. we now report on the antigenicity of the outer membrane components and surface-exposed protein antigens of iron-depleted cells grown in the presence or absence of cephalosporins. all major outer membrane proteins, including iron-regulated membrane proteins, were immunogenic. encapsulate ...	1985	3914857
stoichiometry and kinetics of the interaction of prostaglandin h synthase with anti-inflammatory agents.	we have examined the kinetics, stoichiometry, and chemical nature of the interaction of three anti-inflammatory agents (indomethacin, flurbiprofen, and meclofenamic acid) with pure ovine prostaglandin h synthase. the kinetics of the interaction with the synthase for each of the three agents, monitored by the decrease in cyclooxygenase activity, was consistent with the model proposed by rome and lands (rome, l.h., and lands, w.e.m. (1975) proc. natl. acad. sci. u.s.a. 72, 4863-4865): a rapid and ...	1985	3930499
[the effect of intraperitoneal administration of isoprenaline on atpase activity in the brain of rats of different ages].		1985	3155871
identification of apolipoproteins involved in the interaction of human high density lipoprotein3 with receptors on cultured cells.	human high density lipoprotein (hdl), devoid of apolipoproteins e or b, binds with high affinity and specificity to cultured cells derived from several tissues. in order to investigate the ligand specificity of the putative receptor, we have performed competitive inhibition studies to identify the components of high density lipoprotein that bind to cell surfaces of rat adrenal cortical cells and human skin fibroblasts. radiolabeled hdl3 was displaced with unlabeled apolipoprotein-dimyristoylphos ...	1985	2982866
thio-analogues of inorganic pyrophosphate inhibit the replication of influenza virus a in vitro.	mono- and bisthiopyrophosphate can inhibit the replication of influenza virus a/x49 in madin-darby canine kidney (mdck) cells at concentrations at which no cytotoxic effect is observed after 3 days. the thiopyrophosphate analogues inhibit the rna transcriptase activity of this virus possibly by chelating with an essential metal ion in the transcriptase complex. [31p]nmr spectroscopy indicates that bisthiopyrophosphate coordinates to zinc through sulphur and magnesium through oxygen which may inf ...	1985	2990333
studies on the mechanism of action of omeprazole.	the effects of omeprazole on preparations of pig gastric (h+ + k+)-atpase have been studied. omeprazole was found to inhibit the (h+ + k+)-atpase activity in a time-dependent manner. inhibition was more pronounced at ph 6.1 compared with ph 7.4 and decreased as the concentration of (h+ + k+)-atpase preparation increased. the potency of omeprazole was therefore highly dependent upon the conditions used. when pre- incubated with (h+ + k+)-atpase preparation (30 micrograms protein/ml) for 30 min at ...	1985	2992525
legionella in power station cooling waters.		1985	2862486
multilayer-enzyme linked immunosorbent assay (ml-elisa) for detection of entamoeba histolytica trophozoite coproantigen.	multilayer elisa (ml-elisa) method for entamoeba histolytica trophozoite coproantigen was developed for diagnosis of amoebiasis and its usefulness vis-a-vis microscopic examination analysed for paired specimens from 87 patients from lucknow and hyderabad, india. all the stool specimens positive for trophozoites were also found to be positive in ml-elisa. out of a total 32 samples positive for cysts in microscopy 21 (65.62%) gave positive reactions for coproantigen. results on 26 samples drawn fr ...	1985	2867033
trends in cancer mortality in italy, 1955-1978.	trends in age-specific and age-standardized cancer death certification rates in italy from 1955 to 1978 were analyzed. in males total cancer mortality rates increased in all age groups. however, when respiratory and other tobacco-related neoplasms were excluded, death certification rates were roughly stable up to age 64. moderate decreases in overall cancer mortality have been apparent at younger ages (35-44) since the early 1970's. in females, all the age-specific and the age standardized, unde ...	1985	4024279
preferential uptake of intravenously administered hyaluronidase (hyalosidase) by damaged rat myocardium.	the induction of myocardial infarction in rats by ligation of the left-anterior coronary artery was confirmed by measurement of increased plasma levels of creatine kinase, aspartate aminotransferase and lactate dehydrogenase. using this model system it has been established that intravenous administration of 125i-labelled hyaluronidase to rats resulted in a preferential uptake of the enzyme by damaged myocardium as compared to normal heart tissue.	1985	4027352
enhanced responsiveness of the coronary blood vessel of the dog heart-lung preparation to pgi2 after chronic chemical sympathectomy.	chronic chemical denervation of the sympathetic nervous system with 6-oh dopamine resulted in an augmentation of the coronary blood flow (cbf) increase inherent in the canine heart-lung preparation, but not in an augmented accumulation of 6-keto pgf1 alpha in the circulating blood. in denervated hlp, 6-keto pgf1 alpha was lower and the vasodilator response to pgi2 larger at the start of the experiments. it was concluded that exaggerated increase in cbf was due to a potentiation of the vasodilato ...	1985	3932732
hypercalcemia in the neuroleptic malignant syndrome.	the neuroleptic malignant syndrome (nms) developed in a 32-year-old man following fluphenazine enanthate administration. hypercalcemia was initially present, perhaps reflecting release of calcium from skeletal muscle stores. the elevated serum calcium levels support the existence of a peripheral muscle abnormality in the pathogenesis of the nms and provides another point of similarity between nms and malignant hyperthermia.	1985	3970627
injections of atropine into the caudate nucleus impair the acquisition and the maintenance of passive avoidance.	two experiments were performed to test the hypotheses that cholinergic activity of the caudate nucleus (cn) is involved in the acquisition and in the maintenance of passive avoidance behavior. rats were trained, in one trial, to avoid one of two compartments of a conditioning box and retention of the task was measured 24 hours later. several doses of atropine were injected into the cn of independent groups of animals. in experiment 1 the atropine was injected 2 minutes after training and in expe ...	1985	3983217
excretion of radioactivity in faeces and urine of rats injected with 3h,14c-lipopolysaccharide.	the route of excretion of lipopolysaccharide (lps) and its possible degradation in vivo was studied in rats using biosynthetically radiolabelled lps from salmonella abortus equi, carrying 3h activity exclusively in fatty acids and 14c activity in fatty acids and sugars. following intravenous injection of the above lps in as2 rats with or without anaesthesia, excretion of radioactivity occurred mainly in the faeces and to smaller extent in urine. the rate of excretion was slow, a large part of th ...	1985	4005148
[proportions of the femur and humerus in relation to bone length].	taking as a starting point the known fact that the vertical proportions of man are dependent upon stature, a study has been made to investigate if the relations between individual segments of long tubular bones are also dependent upon overall bone length. for these investigations, use was made of 356 human femurs of unknown sex, which were obtained from the bone collection of the institute of anatomy (kurp 1979), and 70 human humeri of known sex (kropf 1979), which were obtained from the institu ...	1985	4073525
immunization and immunosuppression in mice reared for high or low immune responsiveness against nematospiroides dubius.		1985	4030203
dyschondroplasia/osteochondrosis of the femoral trochanter in the fowl.	of 104 lame broilers, 12 birds with femoral trochanteric abnormalities were identified by post-mortem and radiographic examination. defects occurred in ossification of either the trochanteric zenith or its medial aspect. lesions were identified as dyschondroplasia, osteochondrosis or osteochondrosis dissecans affecting the articular surface of the femoral trochanter. in the absence of concomitant musculoskeletal disease, degrees of lameness can be attributed to trochanteric lesions. breaches in ...	1985	4031131
selective regulation of carboxypeptidase peptide hormone-processing enzyme during enkephalin biosynthesis in cultured bovine adrenomedullary chromaffin cells.	bovine adrenomedullary chromaffin cells in culture were incubated with reserpine or forskolin, two agents acting through different mechanisms, which increase cellular [met]enkephalin levels by 2-fold after 72 h. cells were harvested and chromaffin granules were purified on a linear sucrose gradient. after reserpine treatment, carboxypeptidase-processing enzyme specific activity in chromaffin granule fractions was stimulated 1.9-fold, and co2+-stimulated carboxypeptidase specific activity was sti ...	1985	4039723
extravasation of polymorphonuclear leukocytes from the cerebral microvasculature. inflammatory response induced by alpha-bungarotoxin.	postcapillary venules represent the segment of the microvasculature most vulnerable to inflammatory processes. while there is a considerable body of data on the peripheral vasculature, little is known about the primary events occurring during inflammatory reactions in cerebral blood vessels. we introduce here a model by which the migration of polymorphonuclear leukocytes through the cns endothelial barrier can be studied. alpha-bungarotoxin is used as a chemotactic agent and is shown, for the fi ...	1985	4053172
a rickettsia-like microorganism similar to wolbachia pipientis and its occurrence in culex mosquitoes.		1983	6863975
reproduction of an inbred strain of culex pipiens prevented by loss of wolbachia pipientis.		1983	6404990
guinea pig transfer factor: restriction of macrophage migration inhibitory activity to extraordinary dilution confirmed with demonstration of diminished potency of stored preparations.		1979	88292
serial prolactin and thyrotropin responses to thyrotropin-releasing hormone throughout normal human pregnancy.		1979	107178
persistence of ketosis despite suppression of lipolysis by 16,16-dimethylprostaglandin e2 in experimental diabetic ketoacidosis in rats.		1979	113273
[intravenous cholangiography in hyperbilirubinaemia (author's transl)].	the effect of bilirubin on biliary and renal excretion of methylglucamine-iodipamide at an infusion rate of 1.3, 2.6 and 5.2 mu mol/min/kg was studied by intravenous injection into five dogs with normal liver functions and chronic duodenal fistulas. unconjugated bilirubin administered in a dose of 0.1 mu mol/min/kg reduced biliary iodipamide excretion and concentration significantly, but did not affect renal contrast material excretion. this indicates that the unsatisficatory radiological result ...	1979	153309
an evaluation of three new commercial peptones used in some nutrient media designed for the isolation and characterization of pathogenic vibrios.		1979	262509
origin and early development of canine circumanal glands.		1979	517821
the ultrastructure of the rickettsia-like microorganism wolbachia pipientis and associated virus-like bodies in the mosquito culex pipiens.		1978	671578
ultrastructural localization of calcium around the membrane of the surface connected system in the human platelet.	the localization of calcium in the membrane system of human platelets was determined by ultrahistochemical methods equipped with an electron probe x-ray microanalyzer. after potassium oxalate-glutaraldehyde treatment large amounts of electron opaque precipitates were observed around the membrane of the surface connected system. electron probe x-ray microanalysis clearly defined that the precipitates were composed of calcium oxalate. the localization of calcium on the membrane of the surface conn ...	1978	96043
proceedings of the fifteenth congress of the european dialysis and transplant association, istanbul, turkey, 1978.		1978	33380
tissue fractionation in neurobiochemistry: an analytical tool or a source of artifacts.		1977	22511
an electromyographic study of uterotubal activity in the ewe.	the electrical activity of the oviduct and uterus was automatically registered on a potentiometric pen recorder in ewes fitted with an extracellular multielectrode assembly. the duration and amplitude of local non-propagating activity of the uterus increased and became progressively grouped into phases as natural oestrus progressed. phases of contractions lasting 5-6 min were initially propagated at a rate of 2/hr. their frequency increased within 24 hr of the decline in plasma progesterone leve ...	1976	60491
changes in monoamine oxidase and monoamines with human development and aging.	a series of studies of monoamines and their metabolism in a variety of human tissues indicate that there are aging effects that may alter neurotransmitter substances. monoamine oxidase (mao) activity has a significant positive correlation with age in plasma and blood platelets of normal subjects and patients suffering from depressive disorders. monoamine oxidase and age correlate positively in hindbrain and in eight separate ares of human brains from patients who died from a variety of causes. h ...	1975	1088942
comparative morphology of genital cones of genus ancylostoma dubini, 1843.	male worms of ancylostoma braziliense, a. ceylanicum, a. kusimaense, a. malayanum, a. duodenale, a. caninum, a. tubaeforme, agriostomum vryburgi and cyclodontostomum purvisi have the external appendages beside the anogenital aperture. these anogenital structures are morphologically similar and are assumed to be homologous among the species with three pairs of teeth or more. in hookworms with two pairs of teeth, the anogenital structures are complex. anogenital features can be used as a taxonomic ...	1975	1166351
the effect of magnesium deficiency on serum aldosterone in rats fed two levels of sodium.		1975	1196006
[effects of combination alfaxalone and alfadolone, anesthetic derivatives of pregnanedione, on cerebral hemodynamics in cats].	intravenous injection of ct 1341 (a mixture of alphaxalone and alphadolone dissolved in cremophor el) induced a decrease in cerebral blood flow (cbf) measured by 133xe clearance in cats with artificial respiration (the mean reduction in cbf was 2 ml/100 g/mn for 1,2 mg/kg or ct 1341. so, cbf was decreased by 22% when ct 1341 (7,2 mg/kg) was intravenously injected, (mean pa co2 equals 30 mm hg). changes in cbf following ct 1341 intravenous injection seems to be caused by cerebral vascular constri ...	1975	126719
immunohistochemistry of liver in alpha1-antitrypsin deficiency. a comparative study.		1974	4137719
gamma-aminobutyric acid: drug-induced elevation in monkey brain.		1974	4153580
rate of thrombin-fibrinogen reaction in some mammalian species.		1974	4213348
letter: influenza virus vaccination and renal transplant rejection.		1974	4595178
[abortive infections produced by myxoviruses and rhabdoviruses and their possible causes].		1974	4374832
importance of sperm capacitation for gamete contact in the rabbit.		1974	4413787
importance of sperm capacitation for gamete contact in the rabbit.		1974	4413787
ionic effects on the motility of bull and chimpanzee spermatozoa.		1974	4413987
correlation of c-type virus (wf-1) production and heme synthesis in a rat fibroblastic cell line.		1974	4360116
[functional changes of the thyroid and adrenal glands in the course of immunological reactions].		1973	4144094
effect of weak acids on amino acid transport by penicillium chrysogenum: evidence for a proton or charge gradient as the driving force.	a variety of weak acids at and below their pk(a) are potent inhibitors of transport in penicillium chrysogenum. the effective compounds include sorbate, benzoate, and propionate (common antifungal agents), indoleacetate (a plant hormone), acetylsalicylate (aspirin), hexachlorophene, and a yellow pigment produced by the mycelia under nutrient-deficient conditions, as well as the classical uncouplers 2,4-dinitrophenol, p-nitrophenol, and azide. the results suggest that a proton gradient or charge ...	1973	4632394
study of albumin synthesis in relation to urea synthesis.		1973	4746768
[the teratogenic effect of busulfan on testis cells of the fetal rat].		1973	4800446
alterations in cerebral protein-synthesizing systems during maturation.		1973	4802996
proceedings: correlation of androgenic activities of the lower testosterone esters in rat, with rm values and hydrolysis rates.		1973	4150536
the isolation of erythrocyte membrane proteins in aqueous media.		1972	4199550
agglutination of african primate and rodent erythrocytes by adenoviruses, reoviruses, and enteroviruses.	african nonhuman primate and rodent erythrocytes were tested for agglutination by adenoviruses, reoviruses, and enteroviruses. squirrel erythrocytes were agglutinated by reovirus serotypes and adenovirus types 3, 11, 16, and 21. adenoviruses also agglutinated brazza monkey erythrocytes to the same titers as those obtained with either rhesus or grey monkey cells. prototype reovirus types 1 and 2 agglutinated grey monkey erythrocytes to much lower titers than either squirrel or human group o red c ...	1972	4631106
human skeletal muscle phosphorylase activities with exercise and training.		1972	4640795
[experimental studies for the fluorochroming of human spermatozoa with special reference to so-called vital fluorochroming].		1972	4651092