Publications

epidemic hemorrhagic fever with renal syndrome in yugoslavia, 1986.	an epidemic of hemorrhagic fever with renal syndrome (hfrs) occurred in yugoslavia may-november 1986; all republics and provinces were involved. serum samples were received from 260 of 276 persons with symptoms clinically compatible with a diagnosis of hfrs. presumptive infection with a hantavirus was determined serologically for 161 of these. many patients with serious clinical pictures, including severe renal insufficiency and shock, were hospitalized; 11 died. indirect fluorescent antibody te ...	1989	2569845
hemorrhagic fever with renal syndrome in yugoslavia: antigenic characterization of hantaviruses isolated from apodemus flavicollis and clethrionomys glareolus.	hantavirus antigens were detected in lung tissues of 8/113 apodemus flavicollis and 2/17 clethrionomys glareolus captured in 1984 in fojnica, a region of yugoslavia endemic for hemorrhagic fever with renal syndrome; hantavirus antigens were not detected in lung tissues from 126 other mammals collected in fojnica. three hantaviruses, 2 from a. flavicollis and 1 from c. glareolus, were isolated directly in vero e6 cells and were partially characterized. the isolates from a. flavicollis, designated ...	1989	2569846
[the incidence and clinical picture of hemorrhagic fever with renal syndrome in east slovakia: the eastern and western type].	hemorrhagic fever with renal syndrome (hfrs) is endemic in east slovakia. the paper presents the clinical picture of 4 serologically confirmed cases. two of the 4 patients had serological evidence of recent hantaan virus infection. positive immunofluorescent reactions with puumala virus (cg 18-20) were detected in the sera of the other two patients. the obtained results suggest the circulation of two serotypes of hfrs in slovakia.	1989	2574625
hantavirus-related acute interstitial nephritis in western europe. expansion of a world-wide zoonosis.	we report the clinical, biological and serological characteristics of 76 cases of hantavirus-induced acute interstitial nephritis diagnosed in belgium and france between 1977 and 1986. the disease is characterized by a fever of sudden onset promptly accompanied by pain in the loin or abdomen, nausea and vomiting, myalgias and occasionally with acute myopia and conjunctival injection. within a week acute renal failure develops, necessitating haemo- or peritoneal dialysis in up to 10 per cent of p ...	1989	2576470
detection of nephropathia epidemica (puumala virus)-specific immunoglobulin m by enzyme-linked immunosorbent assay.	nephropathia epidemica (ne), a less severe form of hemorrhagic fever with renal syndrome, is caused by puumala virus (puu). this communication reports the development of a mu-capture enzyme-linked immunosorbent assay (elisa) for detection of specific immunoglobulin m (igm) antibodies to puu virus in human sera. acute- and early-convalescent-phase sera (collected 1 to 41 days after disease onset) from 29 swedish patients with clinical ne were tested for puu virus-specific igg and igm antibodies b ...	1988	2902106
epidemiology of nephropathia epidemica in sweden.	a comprehensive study of nephropathia epidemica (ne), caused by puumala virus, was conducted in sweden. human sera from residents of various regions of sweden were examined for antibody to puumala virus, and the incidence of ne was determined. small mammals were captured at locations throughout sweden and were examined for antibody to puumala virus and for antigen. the human serosurvey found the highest prevalence rates and the highest incidence rates in northern sweden. the bank vole was found ...	1987	2879874
partial characterization of a hantavirus isolated from a clethrionomys glareolus captured in belgium.	a hantavirus was isolated in vero-e6 cells from lungs of a free living bank vole (clethrionomys glareolus) captured in turnhout, province of antwerp--northern part of belgium. with help of monoclonal antibodies the belgian hantavirus isolate could be clearly differentiated from hantaan virus strain 76-118, prospect hill virus strain ph1 and sr11, a hantavirus isolated from laboratory wistar rat in japan, but not from the nephropathia epidemica virus strain hällnäs.	1987	2886029
detection of hemagglutination-inhibiting antibodies in patients with nephropathia epidemica and korean hemorrhagic fever by using puumala virus cell culture antigen.		1986	2871114
epidemiological investigations following an outbreak of hemorrhagic fever with renal syndrome in greece.	epidemiological investigations were conducted following an outbreak of hemorrhagic fever with renal syndrome (hfrs) which occurred in the state of epirus, northwestern greece, in july and august 1983. a total of 8 patients were hospitalized during the outbreak; 3 were severely ill and 1 died. a serosurvey made in may 1984 sampled 184 of the approximately 400 residents of the village of tsepelovo, where 4 patients resided, and found 12 (6.5%) persons, including convalescent sera from 4 patients, ...	1986	2871769
propagation of nephropathia epidemica virus in mongolian gerbils.	nephropathia epidemica virus, the etiological agent of hemorrhagic fever with renal syndrome in scandinavia, was serially propagated in mongolian gerbils (meriones unguiculatus). intracerebrally inoculated suckling gerbils developed subclinical infections, with viral antigen found in lung, brain, liver and spleen. the distribution of viral antigen was similar to that seen in experimentally infected bank voles (clethrionomys glareolus), the principal wild rodent reservoir of nephropathia epidemic ...	1985	3882997
definition of three serotypes of hantaviruses by a double sandwich elisa with biotin-avidin amplification system.	a total of seven different isolates of hantaviruses from five mammalian species and six geographical areas were examined by a double sandwich elisa with biotin-avidin amplification system. three serotypes were recognized by comparing antigen titres to homologous and heterologous antibody and blocking antibody titres to homologous and heterologous antigens. serotype 1 included four strains: hantaan virus isolated from apodemus agrarius in south korea, hupei-i isolated from acute-phase serum from ...	1985	3926952
experimental infection with puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (clethrionomys glareolus).	subclinical chronic infections characterized by transient viremia, prolonged virus shedding in oropharyngeal secretions and feces, and virus persistence in tissues (particularly lung) developed in laboratory-bred weanling bank voles (clethrionomys glareolus) inoculated intramuscularly with puumala virus (strain hällnäs), the etiologic agent of nephropathia epidemica. viral antigen, as evidence by granular fluorescence, was detected in the lungs, liver, spleen, pancreas, salivary glands, and smal ...	1985	2861296
serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests.	antisera prepared against 16 strains of hantaviruses isolated from patients with hemorrhagic fever with renal syndrome (hfrs) or from rodents captured in hfrs-endemic and nonendemic regions were titrated against hantaan virus strain 76-118, puumala virus strain sotkamo, and prospect hill virus strain prospect hill-i by using the indirect immunofluorescent antibody and plaque reduction neutralization tests. isolates fell into one of four distinct groups or serotypes. serotype 1 included apodemus- ...	1985	2866197
[hemorrhagic fever with renal syndrome caused by puumala virus. 2 cases with hypertriglyceridemia in the aube department].		1985	2866508
propagation of nephropathia epidemica virus in cell culture.		1984	6143926
clinical and serological diagnosis of nephropathia epidemica, the mild type of haemorrhagic fever with renal syndrome.	the serological diagnosis of nephropathia epidemica (ne), the mild european type of haemorrhagic fever with renal syndrome (hfrs), was studied by means of an indirect immunofluorescent antibody technique (ifat) in a large outbreak in finland (morbidity 1.4/1000 population). acetone-fixed sections of lung of bank voles (clethrionomys glareolus) naturally infected with puumala virus served as antigen. altogether 65 patients were followed serologically for up to 20 months. serological results obtai ...	1984	6151960
isolation and propagation of nephropathia epidemica virus in bank voles.	three strains of nephropathia epidemica (ne) virus were isolated from lung tissues of bank voles (clethrionomys glareolus) and a grey-sided vole (c. rufocanus) trapped in västerbotten county, sweden. two of these isolates were serially passaged in seronegative laboratory-bred bank voles. experimentally infected animals developed a subclinical infection characterized by virus persistence, particularly in lung tissue. attempts to infect other species of colonized rodents with ne virus and to isola ...	1984	6208601
muroid virus nephropathies and muroid viruses of the hantaan virus group.	hemorrhagic fever with renal syndrome (hfrs) came dramatically to the attention of western medicine in 1951 with the "new" disease becoming a major source of morbidity and mortality in american troops in korea. known there as epidemic hemorrhagic fever (ehf) or korean hemorrhagic fever (khf), it became apparent that it was the same disease as the endemic (epidemic) hemorrhagic nephroso-nephritis of the soviet far east and songo fever of the japanese army in manchuria. the conjecture that the mil ...	1982	6134336