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[survey among female university students on hpv infection epidemiology and prevention].human papilloma virus (hpv) is one of the most common sexually transmitted infections. the vaccine has the maximum benefit when given before starting sexual activity and its efficacy is proved also in sexually active women in which the incidence of the infection is higher. in 2010 a questionnaire on hpv was administered to 299 female students of university of rome tor vergata. the results compared with those obtained in a similar 2007-08 survey, and with international data, showed that knowledge ...201021132046
comparison of self-collected and clinician-collected materials for cervical cytology and human papillomavirus genotyping: analysis by linear array assay.this study compared the usefulness of self-collected (sc) and clinician-collected (cc) materials for cervical cytology and human papillomavirus (hpv) genotyping.201021135530
the hpv16 e6 binding protein tip-1 interacts with arhgef16, which activates cdc42.guanidine exchange factor (gef)-catalysed activation of rho proteins such as cdc42 has been shown to have a crucial role in cellular transformation, malignant progression and invasion. we have previously shown that the hpv16 e6 oncoprotein binds to the pdz domain protein tax-interacting-protein 1 (tip-1) and we now report identification and functional analysis of a novel tip-1 binding gef.201021139582
integrating novel primary- and secondary-prevention strategies: the next challenge for cervical cancer control.the advent of prophylactic vaccines against human papillomavirus (hpv) infection, the cause of cervical cancer, and of new molecular methods to screen for this disease have become key developments in cancer control in the last 5 years. although pap cytology has had a significant history as a key method for cervical cancer screening, not all countries have benefited from this technology or have been able to implement the necessary public health steps to manage and treat the precancerous lesions t ...201021142659
vaccination against human papillomavirus types 16 and 18: the impact on cervical cancer. 201021142854
introduction of hematoxylin as an electroactive label for dna biosensors and its employment in detection of target dna sequence and single-base mismatch in human papilloma virus corresponding to oligonucleotide.for the detection of dna hybridization, a new electrochemical biosensor was developed on the basis of the interaction of hematoxylin with 20-mer deoxyoligonucleotides (from human papilloma virus, hpv). the study was performed based on the interaction of hematoxylin with an alkanethiol dna probe self-assembled gold electrode (ss-dna/aue) and its hybridization form (ds-dna/aue). the optimum conditions were found for the immobilization of hpv probe on the gold electrode (aue) surface and its hybrid ...201021146975
aptima hpv e6/e7 mrna test is as sensitive as hybrid capture 2 assay but more specific at detecting cervical precancer and cancer.detection of human papillomavirus (hpv) e6/e7 oncogene expression may be more predictive of cervical cancer risk than testing for hpv dna. the aptima hpv test (gen-probe) detects e6/e7 mrna of 14 oncogenic types. its clinical performance was compared with that of the hybrid capture 2 dna test (hc2; qiagen) in women referred for colposcopy and those routinely screened. aptima was also compared with the pretect hpv-proofer e6/e7 mrna assay (proofer; norchip) in the referral population. cervical sp ...201021147950
human papillomavirus e7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases.infection by human papillomaviruses (hpv) leads to the formation of benign lesions, warts, and in some cases, cervical cancer. the formation of these lesions is dependent upon increased expression of proangiogenic factors. angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-inducible factor 1α (hif-1α). our studies indicate that the hpv e7 protein enhances hif-1 transcriptional activity whereas e6 functions to counteract the repressive effects of p53. bo ...201021148070
prevalence and determinants of high-risk human papillomavirus infection in women from a sub-saharan african community.background:: human papillomavirus infection with high-risk types (hr-hpv) is a necessary cause of cervical cancer, the most common malignancy among sub-saharan african women. little is known about prevalence of cervical hr-hpv infection in this region. methods:: a cross-sectional study of 1528 women examined the determinants of hr-hpv infection among women in kinshasa, democratic republic of congo. information was collected on sociodemographic, reproductive, lifestyle characteristics, and health ...201021150817
computer-aided analysis of structural properties and epitopes of iranian hpv-16 e7 oncoprotein.infection by human papillomavirus type 16 (hpv-16) is the cause of 50% or more of cervical cancers in women. the e7 oncoprotein of hpv-16 has long been known as a potent immortalizing and transforming agent. we used different servers like pseaac, mhc_binding, mhc_ii_binding and expasy for the present computational prediction. the results for t cell epitopes showed that b1501, a0203, a0201, a0202, a6801 and drb0405 alleles had lower ic50 than other alleles. we also predicted several peptides with ...201021153780
expression of cytokines in cervical stroma in patients with high-grade cervical intraepithelial neoplasia after treatment with intralesional interferon alpha-2b.conservative treatment with interferons (ifns) has the advantage of preserving reproductive capacity in patients with grade 2 or 3 cervical intraepithelial neoplasia (cin). the objective of this work was to study patients with high-grade cin treated with intralesional ifn alpha-2b and to analyze the expression of th1, th2 and th3 cytokines in cervical stroma. we observed that patients with a satisfactory response (60%) to treatment with ifn alpha-2b expressed more th1 (ifn-gamma tnf-alpha, il-2) ...201021061793
the clinical significance of hpv screening in premalignant cervical lesions.we evaluated the clinical significance of human papilloma virus (hpv) screening in premalignant cervical lesions.201021061813
hpv vaccine acceptance among female greek students.the human papillomavirus (hpv) vaccine protects against hpv-related disease. the aim of this study was to assess acceptance of hpv vaccination among female greek students. a sample of 573 students aged 18-25 years participated in the present study. interviews were performed using a structured questionnaire. of the respondents, 3% were not aware of the hpv vaccine. of the subjects, 10.47% had been administered the hpv vaccine. of the respondents who had not been administered the vaccine, 43.86% w ...201021061928
integrative genomic approaches in cervical cancer: implications for molecular pathogenesis.cervical cancer (cc) as a single diagnostic entity exhibits differences in clinical behavior and poor outcomes in response to therapy in advanced tumors. although infection of high-risk human papillomavirus is recognized as an important initiating event in cervical tumorigenesis, stratification of cc into subclasses for progression and response to treatment remains elusive. existing knowledge of genetic, epigenetic and transcriptional alterations is inadequate in addressing the issues of diagnos ...201021062161
cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings.baseline information on human papillomavirus (hpv) prevalence and type distribution is highly desirable to evaluate the impact of prophylactic hpv vaccines in the near future.201021067372
quadrivalent human papillomavirus vaccination and trends in genital warts in australia: analysis of national sentinel surveillance data.quadrivalent human papillomavirus (hpv) vaccine has high efficacy in clinical trials but no reports describe its effects at a population level. from july, 2007, australia was the first country to fund a vaccination programme for all women aged 12-26 years. we established a national surveillance network in australia and aimed to identify trends in diagnoses of genital warts in 2004-09.201021067976
human papillomavirus (hpv) types 16, 18, 31, 45 dna loads and hpv-16 integration in persistent and transient infections in young women.hpv burden is a predictor for high-grade cervical intraepithelial neoplasia and cancer. the natural history of hpv load in young women being recently exposed to hpv is described in this paper.201021070660
systemic lupus erythematosus, human papillomavirus infection, cervical pre-malignant and malignant lesions: a systematic review.the purpose of this study was to review and evaluate systematically the scientific evidence on the relationship between systemic lupus erythematosus (sle), human papillomavirus (hpv) infection, pre-cancerous cervical abnormalities, and cervical cancer. establishing strict inclusion and exclusion criteria, we performed an extensive search for studies in medline and bireme databases to assess the studies that evaluated the frequency of hpv infection, pre-cancerous cervical abnormalities, and cervi ...201021072553
genomic instability and cancer: lessons learned from human papillomaviruses.high-risk hpv e6 and e7 oncoproteins cooperate to subvert critical host cell cycle checkpoint control mechanisms in order to promote viral genome replication. this results not only in aberrant proliferation but also in host cellular changes that can promote genomic instability. the hpv-16 e7 oncoprotein was found to induce centrosome abnormalities thereby disrupting mitotic fidelity and increasing the risk for chromosome missegregation and aneuploidy. in addition, expression of the high-risk hpv ...201021075512
human papillomavirus (hpv)-type distribution in relation to oral contraceptive use in women with cervical intraepithelial neoplasia, durban, south africa.to determine hpv-type distribution among women with cervical dysplasia in relation to oral contraceptive usage.201021077468
differential expression of cellular micrornas in hpv-11 transfected cells. an analysis by three different array platforms and qrt-pcr.human papillomavirus type 11 (hpv-11) infects the genital and the respiratory tract leading to condylomas and respiratory papillomatosis. hpv infections are restricted to epithelial tissue and the progression through the virus lifecycle is tightly coordinated to the differentiation of the host cell. the changes of cellular micrornas by hpv-11 gene expression were investigated in a cell culture model of hacat cells transfected with hpv-11, with the goal of understanding which cellular processes w ...201021078297
human papillomavirus: the silent intruder. 201021079318
author's reply to: multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants. 201021080437
civil society: a critical new advocate for vaccination in europe.the vaccinology landscape has changed, with national authorities now being increasingly accountable to new stakeholders such as health insurers, regional regulatory bodies, the media, and civil society. here, we discuss how civil society organisations (csos), such as patient and women's groups, have become important drivers in the introduction and sustainability of new vaccination programs. this shift in public implication in vaccine policy has been well illustrated in the recent introduction of ...201021081178
cost-effectiveness of screening high-risk hiv-positive men who have sex with men (msm) and hiv-positive women for anal cancer.anal cancer is uncommon and predominantly a disease of the elderly. the human papillomavirus (hpv) has been implicated as a causal agent, and hpv infection is usually transmitted sexually. individuals who are human immunodeficiency virus (hiv)-positive are particularly vulnerable to hpv infections, and increasing numbers from this population present with anal cancer.201021083999
prospective evaluation of longitudinal changes in human papillomavirus genotype and phylogenetic clade associated with cervical disease progression.changes in the hpv genotype detected in patients over time could alter cervical disease progression. identification of patterns in the alteration of hpv genotype should also be related to cytological and histological findings. thus, we assessed the risk for low-grade squamous intraepithelial lesion (lsil) or high-grade sil (hsil)/squamous cell carcinoma (scc) associated with alterations in the hpv genotype detected, presence of multiple hpv genotypes, and individual genotyping or hpv clade group ...201021087788
assessment of immunohistochemistry for p16ink4 and high-risk hpv dna by in situ hybridization in esophageal squamous cell carcinoma.the role of high-risk human papillomavirus (hpv) in the pathogenesis of esophageal squamous cell carcinoma (escc) remains unclear. p16(ink4) is used as a surrogate marker to detect hpv-related tumors but has had discrepant results in escc. in this study, 32 cases of escc were examined to determine the relationship between p16(ink4) expression and high-risk hpv. all the tumors were stained by immunohistochemistry for p16(ink4). tumors having p16(ink4) nuclear and/or nuclear and cytoplasmic expres ...201021087981
maternal support for human papillomavirus vaccination in honduras.cervical cancer is a leading cause of cancer death for women in latin america, and vaccinating against human papillomavirus (hpv) has the potential to limit this disease. we sought to determine honduran women's awareness of hpv vaccination and interest in vaccinating their daughters against hpv.201021091226
condyloma accuminata: what's in a name? 201021093667
factors associated with initiation and completion of human papillomavirus vaccine series among young women enrolled in medicaid.to determine age- and race-specific uptake rates of human papillomavirus (hpv) vaccine among females aged 9-20 years who participated in the florida medicaid during the first 2 years after approval by the food and drug administration, and to identify factors associated with hpv vaccine initiation and series completion.201021094437
chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohort.cofactors might affect the risk of the rare progression from infection with carcinogenic human papillomavirus (hpv) to cervical premalignancy to invasive cancer. some studies have observed that chlamydia trachomatis infection is associated with increased risk for cervical cancer. in a large prospective cohort, we assessed the role of c trachomatis in cervical premalignancy and addressed confounding by hpv.201021098758
colposcopy prediction of progression in human papillomavirus infections with minor cervical lesions.to evaluate the risk of progression to cervical intraepithelial neoplasia (cin) grade 2 or 3 in women with positive human papillomavirus (hpv) testing and low-grade (low-grade squamous intraepithelial lesions), borderline (atypical squamous cells of undetermined significance), or no cervical lesions, and to determine the accuracy of initial colposcopy to predict progression.201021099598
common abnormal results of pap and human papillomavirus cotesting: what physicians are recommending for management.to evaluate the association between physician and practice characteristics and adherence to management guidelines to better understand the factors associated with different screening recommendations by primary care physicians.201021099599
projecting the need for gynecologic oncologists for the next 40 years.to estimate the ratio of gynecologic cancer cases to practicing gynecologic oncologists in the united states over the next 40 years.201021099604
rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young women.to describe the natural history of cervical intraepithelial neoplasia (cin) 2 in a prospective study of adolescents and young women, and to examine the behavioral and biologic factors associated with regression and progression.201021099605
inhibition of cervical cancer cell growth in vitro and in vivo with dual shrnas.rna interference (rnai)-based gene silencing is widely used in laboratories for gene function studies and also holds a great promise for developing treatments for diseases. however, in vivo delivery of rnai therapy remains a key issue. lentiviral vectors have been employed for stable gene transfer and gene therapy and therefore are expected to deliver a stable and durable rnai therapy. but this does not seem to be true in some disease models. here, we showed that lentivirus delivered short-hairp ...201021102424
human papillomavirus genotype distribution in cervical samples collected in routine clinical practice at the nantes university hospital, france.objective: the objective was to assess the human papillomavirus (hpv) overall and type-specific prevalence in smears collected during routine clinical practice. design: hpv genotyping and smears were performed independently between 2000 and 2006 for routine clinical follow-up (primary screening and follow-up) in the university hospital of nantes, france. population: all women with a cytological sample collected no more than 12 months before hpv genotyping were included. methods: pcr was performe ...201021107591
controversy undermines support for state mandates on the human papillomavirus vaccine.state actions requiring adolescent girls to receive the human papillomavirus (hpv) vaccine created controversy following the vaccine's approval in 2006. some health professionals worried that the controversy might dampen public support for those state policies and for other school immunizations in general. we fielded an experimental internet survey to determine how controversy affects attitudes about vaccines. we discovered that public support for the hpv vaccine mandates wanes when the public i ...201021041746
[the study of gene variation and phylogenetic analysis of hpv16 e6 and e7 gene in hubei, china].to study the gene variation and the distribution of hpv16 variant in hubei, china, dna was extracted from cervical cancer tissue samples. the e6 and e7 genes of hpv16 were amplified and the pcr products were sequenced using e6- and e7-specific primers. fortyseven cases were found mutations at nucleotide position 178 of hpv16 e6 gene in 80 cervical cancer samples. this mutation resulted in amino acid change from asp to glu. the rate of mutation at nucleotide position 178 of e6 gene was 58. 75%. t ...201021043136
putative mechanisms of antitumor activity of cyano-substituted heteroaryles in hela cells.six recently synthesized cyano-substituted heteroaryles, which do not bind to dna but are highly cytotoxic against the human tumor cell line hela, were analyzed for their antitumor mechanisms of action (moa). they did not interfere with the expression of human papillomavirus oncogenes integrated in the hela cell genome, but they did induce strong g1 arrest and result in the activation of caspase-3 and apoptosis. a computational analysis was performed that compared the antiproliferative activitie ...201021046426
human papillomavirus disease and vaccines in adolescents.review of the most recent evidence indicates that screening for cervical cancer in females younger than 21 years of age likely leads to more harm than good. in addition, screening during adolescence has not lead to decreased cervical cancers in this age group. the rate of cervical cancer remains extremely low in adolescents. in contrast, abnormal cytology is extremely common, of which most is benign. hence, referral to colposcopy is unnecessary and costly. new guidelines recommend cervical cance ...201021047033
thermodynamics of cooperative dna recognition at a replication origin and transcription regulatory site.binding cooperativity guides the formation of protein-nucleic acid complexes, in particular those that are highly regulated such as replication origins and transcription sites. using the dna binding domain of the origin binding and transcriptional regulator protein e2 from human papillomavirus type 16 as model, and through isothermal titration calorimetry analysis, we determined a positive, entropy-driven cooperativity upon binding of the protein to its cognate tandem double e2 site. this cooper ...201021047141
quality of life of homosexual males with genital warts: a qualitative study.abstract:201021050431
[effect of adenovirus delivered tissue inhibitor of metalloproteinases 3 on the irradiation sensitivity of human papillomavirus positive cervical cancer cells].to explore the effects of adenovirus-delivered tissue inhibitor of metalloprotein- ases-3 (ad-timp-3) on the irradiation sensitivity of human papillomavirus (hpv)-positive cervical cancer cells.201021050555
seroprevalence of human papillomavirus 6, 11, 16, and 18 in young primiparous women in sao paulo, brazil.data on epidemiology of hpv infection are needed for the development of human papillomavirus (hpv) vaccine recommendations, especially in countries where hpv vaccination is not yet included in public vaccination programs. the aim of this study was to determine the prevalence of serum antibodies to hpv types 6, 11, 16, and 18 and associated factors among young women after birth of the first child.201021051985
human papillomavirus and epstein barr virus in oral hairy leukoplakia among hiv positive venezuelan patients.oral hairy leukoplakia (ohl) is commonly found in individuals infected with hiv and represents the most frequent oral manifestation. the purpose of this study was to detect the presence of human papillomavirus (hpv) and epstein barr virus (ebv) in ohl of hiv+ venezuelan patients. we evaluated 21 hiv+ adult patients with clinically present ohl lesions: 11 under antiretroviral therapy, 10 without therapy, and 10 oral mucosal samples as controls. nested-pcr was used to detect ebv and hpv infection. ...201021053684
feasibility of using maternal cancer screening visits to identify adolescent girls eligible for human papillomavirus vaccination.breast or cervical cancer screening visits may present an opportunity to motivate mothers to have their daughters vaccinated against human papillomavirus (hpv). in preparation for a future intervention study, we sought to establish the feasibility of using these visits to identify women with at least one daughter in the appropriate age range for adolescent hpv vaccination.201021054184
detection of human papilloma virus in normal skin and in superficial and nodular basal cell carcinomas in immunocompetent subjects.background  human papilloma virus (hpv) is increasingly recognized as an important human carcinogen but its role in the aetiopathogenesis of basal cell carcinoma (bcc) in immunocompetent individuals is unclear. objective  a prospective case-control study was designed to compare the prevalence of hpv in bcc and normal skin samples from immunocompetent subjects and to assess the influence of different clinical features on the risk of cutaneous hpv. methods  a total of 142 samples from 70 bcc cases ...201021054564
advancements in the control of genital human papillomavirus infections and related diseases: highlighting australia's role. 201021058495
commentary on opinion pieces re australian human papillomavirus vaccine policy. 201021058498
development of peptide aptamer microarrays for detection of hpv16 oncoproteins in cell extracts.protein microarrays represent an emerging technology that promises to facilitate high-throughput proteomics. the major goal of this technology is to employ peptides, full-length proteins, antibodies, and small molecules to simultaneously screen thousands of targets for potential protein-protein interactions or modifications of the proteome. this article describes the performance of a set of peptide aptamers specific for the human papillomavirus (hpv) type 16 oncoproteins e6 and e7 in a microarra ...201021059336
the association between dietary intake and cervical intraepithelial neoplasia grade 2 or higher among women in a high-risk rural area of china.objective: to evaluate the relationship between dietary intake and risk of cervical intraepithelial neoplasia grade 2 or higher (cin2+) while controlling for human papillomavirus (hpv) infection. methods: in 1999 and 2002, 11,031 women aged 35-50, were screened as part of two cross-sectional population-based cervical cancer screening studies in china. dietary food intake information was collected by a 79-item food frequency questionnaire (ffq). 748 hpv-positive women (557 normal biopsy; 95 cin2, ...201021061128
aberrant expression and constitutive activation of stat3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection.recent observations indicate potential role of transcription factor stat3 in cervical cancer development but its role specifically with respect to hpv infection is not known. present study has been designed to investigate expression and activation of stat3 in cervical precancer and cancer in relation to hpv infection during cervical carcinogenesis. established cervical cancer cell lines and prospectively-collected cervical precancer and cancer tissues were analyzed for the hpv positivity and eva ...201020977777
[cervical intraepithelial neoplasia 2+ in low-grade squamous intraepithelial lesion pathologically diagnosed by colposcopy-assisted biopsy].to assess the accuracy of colposcopy-assisted biopsy for the diagnosis of cervical intraepithelial neoplasia i (cin(1)) and to reappraise the correlative factors of missed cin(2+) in low-grade sil(squamous intraepithelial lesion)pathologically diagnosed by colposcopy-assisted biopsy.201020979903
p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression.p38 kinases activated by growth factors, hormones, and environmental stresses exert diverse functions in regulating normal and malignant cell pathophysiology. enhanced levels of activated p38 isoforms have been linked with poor prognosis in breast cancer, although the mechanistic basis for this association is poorly understood. in this study, we report that p38 activation in cervical cancer cells is driven by osteopontin (opn), an extracellular matrix-associated cytokine that drives invasive pro ...201020980434
differential regulation of human papillomavirus type 8 by interferon regulatory factors 3 and 7.the genus β human papillomavirus (hpv) type 8 is associated with nonmelanoma skin cancer in patients with epidermodysplasia verruciformis, and evidence for its protumorigenic potential in the general population increases. to date, strategies to suppress genus β hpv infections are limited. interferon regulatory factors irf-3 and irf-7 play key roles in the activation of the innate immune response to viral infections. in this study, we show for the first time that both irf-3 and irf-7 regulate tra ...201020980500
oropharyngeal cancer epidemic and human papillomavirus.a growing body of research shows that human papillomavirus (hpv) is a common and increasing cause of oropharyngeal squamous cell carcinoma (oscc). thus, the international agency for research against cancer has acknowledged hpv as a risk factor for oscc, in addition to smoking and alcohol consumption. recently, in finland, the united kingdom, the netherlands, the united states, and sweden, incidence of oscc has increased, and an increase in the proportion of hpv-positive tumors was noted. on the ...201021029523
[association between hpv infection and hla-dqb1 alleles polymorphism in the cervical carcinogenesis in uyghur women in southern xinjiang].to investigate the association between hpv infection and hla-dqb1 alleles polymorphism in the cervical carcinogenesis in uyghur women in southern xinjiang.201021029690
high-risk human papillomavirus dna in paraaortic lymph nodes in advanced stages of cervical carcinoma.paraaortic lymph nodes represent the second level in the lymphatic spread of cervical cancer. recent studies have confirmed the association of hpv dna in pelvic lymph nodes in early-stage disease with metastatic involvement and a less favourable prognosis.201021035386
expression of nonclassical molecule human leukocyte antigen-g in oral lesions.introduction: human leukocyte antigen (hla)-g is a nonclassic class i molecule that acts as a modulator of immune responses, and the expression of these molecules in virus-infected cells has been associated with subversion of the immune response. objective: in this study, we performed a cross-sectional study, systematically comparing the expression of the hla-g in benign, premalignant, and malignant oral lesions and correlating it with the presence of high-risk and low-risk human papillomavirus ...201021035918
human papilloma virus vaccination in nepal: an initial experience in nepal.cervical cancer is the most common cancer among women in nepal. human papilloma virus (hpv) infection, a recognized cause of cervical cancer, is very common in sexually active women and hpv vaccination has been recommended as a prophylactic therapy. if hpv infection is prevented by the hpv vaccination to the adolescent girls, cervical cancer is also prevented. we received 3,300 vials of quadrivalent human papilloma virus (types 6, 11, 16, 18) recombinant vaccine (gardasil; merck and co.) as a gi ...201021039025
hpv vaccine acceptance among women in the asian pacific: a systematic review of the literature.to inform human papillomavirus (hpv) vaccination programs in the asian pacific region by elucidating factors associated with women's intent to receive the vaccine.201021039030
the attitudes of australian gynaecologists to hpv vaccination: an asccp survey.with human papilloma virus (hpv) vaccines now approved for women up to 45 years of age, gynaecologists in australia will be approached increasingly for advice on whether to have the hpv vaccine.201021039383
disparities in human papillomavirus vaccine series initiation among adolescent girls enrolled in florida medicaid programs, 2006-2008.to better understand the human papillomavirus (hpv) vaccine series initiation among 9-17-year-old female medicaid beneficiaries in florida programs between june 2006 and december 2008 (n = 237,015).201020864008
medical and surgical approaches to vulvar intraepithelial neoplasia.vulvar intraepithelial neoplasia (vin) is a precursor to invasive vulvar carcinoma. the two major types of vin, usual and differentiated, differ in epidemiology, pathogenesis, clinical manifestations, pathology, and malignant potential. usual vin commonly occurs in younger women. it is associated with human papillomavirus and tends to have multifocal and multicentric involvement. differentiated vin is frequently associated with benign vulvar dermatoses such as lichen sclerosus and lichen simplex ...201020868402
[infection of human papillomavirus 16/18 dna in patients with head and neck squamous cell carcinoma and its relationship with expression of ki-67 and p53 protein].to detect the infection of human papillomavirus (hpv) 16/18 in patients with head and neck squamous cell carcinoma and explore the relationship between hpv infection and expressions of ki-67 and p53 proteins in tumor tissue.201020868604
human papillomavirus-positive basaloid squamous cell carcinomas of the head and neck. 201020868902
cervical cancer working group report.disease burden of cervical cancer in asia was summarized. human papillomavirus 16 is the most oncogenic human papillomavirus type. korea's national cervical cancer screening program targets women aged 30 or over, with coverage of almost 80%. japan has a long history (50 years) of cervical cancer screening, and cytological screening programs have reduced the incidence/mortality of cervical cancer by 70%. but, recent cervical cancer screening coverage is ∼24%. modeling suggested that vaccination o ...201020870919
prevalence of low-risk and high-risk types of human papillomavirus and other risk factors for hpv infection in germany within different age groups in women up to 30 years of age: an epidemiological observational study.human papillomavirus (hpv) infection is frequent in young women and persistent infection may lead to cervical cancer. therefore, vaccination against hpv is recommended for young women in the age group from 12-17 years in germany. however, epidemiological data on the prevalence of hpv types and risk factors for infection for younger women in germany is scarce. to address this, an observational study was performed in germany including 1,692 women aged 10-30 years. after a routine pap smear, cervic ...201020872721
mutational analysis of kinetic partitioning in protein folding and protein-dna binding.kinetic partitioning between competing routes is present in many biological processes. here, we propose a methodology to characterize kinetic partitioning through site-directed mutagenesis and apply it to parallel routes for unfolding of the ti i27 protein and for recognition of its target dna by the human papillomavirus e2 protein. the balance between the two competing reaction routes can be quantified by the partitioning constant k(p). k(p) is easily modulated by point mutations, opening the w ...201020876193
composite cervical adenocarcinoma composed of adenoma malignum and gastric type adenocarcinoma (dedifferentiated adenoma malignum) in a patient with peutz jeghers syndrome.an unusual cervical adenocarcinoma is reported in a 50-year-old woman with a history of peutz jeghers syndrome. the carcinoma contained two morphologically distinct and spatially separate components, one comprising typical well differentiated adenoma malignum and the other a moderately differentiated neoplasm, in keeping with gastric type adenocarcinoma. both components were positive for hik1083 and muc6 and negative for p16, and did not contain human papillomavirus. it is believed that such a c ...201020876329
cervical hpv infection in brazil: systematic review.to assess the prevalence of human papillomavirus (hpv) infection in women in brazil.201020877926
hpv knowledge in mexican college students: implications for intervention programmes.in order to promote new human papillomavirus (hpv) prevention and detection methods effectively in mexico, it is important to understand how much the population knows about the virus. this study aimed to determine the demographic and behavioural factors associated with hpv awareness and knowledge in a population of mexican college students. with a response rate of 77%, data were collected from 1109 college students aged 17-25 years old at the autonomous university of the state of morelos in 2006 ...201020880104
atypical clinical behavior of p16-confirmed hpv-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy.purpose: to report atypical clinical behavior observed in human papillomavirus (hpv)-related oropharyngeal carcinoma (opc) treated with radiotherapy. methods and materials: a retrospective cohort study was conducted for all newly diagnosed opc cases treated with radiotherapy on july 1, 2003 to april 30, 2009. hpv positivity was determined by p16 immunostaining in tumors. the incidence of additional malignancies and the pattern of distant metastases (dms) were compared between the hpv-positive (h ...201020950953
evolution of human papillomavirus carcinogenicity.members of the alphapapillomavirus genus are the causative agent for virtually all cases of cervical cancer. however, strains (commonly referred to as types) within this genus span the entire range of pathogenicity from highly carcinogenic (e.g., hpv16, odds ratio = 281.9, responsible for 50% of all cervical cancers), moderately carcinogenic (e.g., hpv31) to not carcinogenic (e.g., hpv71). the persistent expression of the viral oncoproteins (e6 and e7) from hpv16 has been shown to be necessary a ...201020951869
behavioral/lifestyle and immunologic factors associated with hpv infection among women older than 45 years.cervical human papilloma virus (hpv) detection increases after menopause, but its determinants need clarification.201020952561
molecular and structural characterization of the l1 virus-like particles that are used as vaccine antigens in cervarix™, the as04-adjuvanted hpv-16 and -18 cervical cancer vaccine.cervarix™ is a prophylactic human papillomavirus (hpv)-16/18 vaccine developed for the prevention of cervical cancer. the vaccine antigens are hpv-16 and hpv-18 l1 virus-like particles (vlps) made from baculovirus expression vector system (bevs)-produced hpv-16 and hpv-18 l1 proteins, respectively. in this study, we demonstrate that truncation of the nuclear targeting and dna binding signals at the c-terminus of the hpv-16 and hpv-18 l1 proteins prevented intranuclear formation of the vlps in th ...201020953154
evaluating societal preferences for human papillomavirus vaccine and cervical smear test screening programme.cervical cancer and genital warts are diseases associated with human papillomavirus (hpv) infection. cervical smear testing is used as a cervical cancer screening tool in most countries worldwide. the newly introduced vaccines that prevent hpv infections are the quadrivalent vaccine (gardasil), which prevents genital warts and cervical cancer, and the bivalent vaccine (cervarix), which prevents cervical cancer only. public preferences for hpv vaccines and smear test screening were determined usi ...201020956352
regression of cutaneous warts in a patient with wild syndrome following recombinant quadrivalent human papillomavirus vaccination. 201020956677
breast and cervical cancer screening programme implementation in 16 countries.there is a continuing need to monitor and evaluate the impact of organized screening programmes on cancer incidence and mortality. we report results from a programme assessment conducted within the international cancer screening network (icsn) to understand the characteristics of cervical screening programmes within countries that have established population-based breast cancer screening programmes.201020956724
hierarchical clustering of human papilloma virus genotype patterns in the ascus-lsil triage study.anogenital cancers are associated with ∼13 carcinogenic human papilloma virus (hpv) types in a broader group that cause cervical intraepithelial neoplasia (cin). multiple concurrent cervical hpv infections are common, which complicates the attribution of hpv types to different grades of cin. here we report the analysis of hpv genotype patterns in the atypical squamous cells of undetermined significance-low-grade squamous intraepithelial lesion triage study with the use of unsupervised hierarchic ...201020959485
human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy.this study examines the prognostic significance of human papillomavirus (hpv) in patients with locally advanced oropharyngeal squamous cell carcinoma (scc) treated primarily with surgery or definitive radiotherapy.201020959828
[association between penoscopy data and urethral cytology among men with partners who had cervical lesions associated with human papilloma virus].the aim of this study was to identify human papillomavirus lesions in a group of men whose sexual partners had cervical intraepithelial lesions associated with low-grade hpv confirmed by pcr-dna. we carried out a correlation between urethral cytology penoscopy data and pcr-dna results.201020964071
immunohistological analysis of hpv l1 capsid protein and p16 protein in low-grade dysplastic lesions of the uterine cervix.human papillomavirus (hpv) l1 capsid protein (l1) is associated with the productive phase of hpv infection. however, the expression of l1 and its relationship to p16 expression, a surrogate marker for hpv infection, are unknown. we examined the relationship between l1 and p16 expression in cervical intraepithelial neoplasia. tissues were divided into four categories: regressive lesions (n=48), progressive lesions (n=40), and randomly selected cin1-2 (n=67) and cin3 (n=44). p16 positivity in the ...201020965668
evaluation of a liquid bead array system for high-risk human papillomavirus detection and genotyping in comparison with hybrid capture ii, dna chip and sequencing methods.since persistent infection with high-risk human papillomavirus (hpv) is a known cause of high-grade cervical intraepithelial neoplasia and cervical cancer, several hpv dna detection methods have been developed during the last decade. the hybrid capture ii (hcii) assay, which allows detection of 13 high-risk hpvs, has been well validated; however, it does not provide any genotype-specific information. the oncogenic activity of hpv is dependent on its genotype. the prophylactic effects of hpv vacc ...201020965919
the presence of human papillomavirus or p16 in six cases of retroperitoneal carcinoma.to describe six cases of unknown primary carcinoma of the retroperitoneum that were positive for human papillomavirus (hpv), a surrogate molecular marker for high-risk hpv (p16), or both.201020966687
investigation of the influence of high-risk human papillomavirus on the biochemical composition of cervical cancer cells using vibrational spectroscopy.the main aetiology of cervical cancer is infection with high-risk human papillomavirus (hpv). cervical cancer is almost 100% curable if detected in the early stages. thus, information about the presence and levels of hpv in patient samples has high clinical value. as current screening methods, such as the pap smear test, are highly subjective and in many cases show low sensitivity and specificity, new supportive techniques are desirable to improve the quality of cervical cancer screening. in thi ...201020967345
determinants of head and neck cancer survival by race.background: several factors contribute to the documented racial disparity in head and neck cancer, among which are socioeconomic status, access to care, and biologic factors. methods: clinical characteristics of 87 african-american patients with head and neck cancer and a random sample of 261 white patients matched on age and smoking dose were associated with outcome. results: black patients with cancers of the oral cavity and larynx were more likely diagnosed with advanced stages than whites, a ...201020967872
[human papilloma virus genotyping in women with cin 1].cervical cancer remains a considerable diagnostic and therapeutic problem in poland. despite progress in creating an active cancer prevention program in our country poland occupies one of the last places in the eu in terms of cervical cancer- morbidity and mortality supplement of secondary prevention of primary prophylaxis-hpv 16, 18 vaccination, offers hope for improvement of the situation. epidemiology of individual hpv types differs, depending on the geographical location of the study populat ...201020973202
human papilloma virus transformed caski cells constitutively express high levels of functional serpinb2.many malignant tissues, including human papilloma virus (hpv)-associated cancers, express serpinb2, also known as plasminogen activator inhibitor type-2 (pai-2). whether serpinb2 is expressed by the hpv-transformed cancer cells, and if so, whether serpinb2 is mutated or behaves aberrantly remains unclear. here we show that hpv-transformed caski cells express high levels of constitutive wild-type serpinb2, with cellular distribution, glycosylation, secretion, cleavage, induction and urokinase bin ...201020974129
detection of human papillomavirus type 67 from bowenoid papulosis. 201020974556
skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model.better delivery systems are needed for routinely used vaccines, to improve vaccine uptake. many vaccines contain alum or alum based adjuvants. here we investigate a novel dry-coated densely-packed micro-projection array skin patch (nanopatch™) as an alternate delivery system to intramuscular injection for delivering an alum adjuvanted human papillomavirus (hpv) vaccine (gardasil®) commonly used as a prophylactic vaccine against cervical cancer.201020976136
effects of photodynamic therapy using topical applied hexylaminolevulinate and methylaminolevulinate upon the integrity of cervical epithelium.cervical intraepithelial neoplasia (cin) is associated with genital human papillomavirus (hpv) infection and represents the precursor of cervical cancer. established ablative treatment methods may cause substantial complications in following pregnancies including premature delivery and the birth of low-weight babies. photodynamic therapy (pdt) of cin using esters of 5-aminolevulinic acid (5-ala) represents a promising alternative. however, it has not been analyzed yet if the pdt itself leads to ...201020976802
novaprep(®) vial test is a suitable liquid-based cytology medium for high risk human papillomavirus testing by hybrid capture 2.liquid-based cytology (lbc) for cervical cancer screening presents the advantage that cytological and virological investigations can be undertaken from the same specimen. nevertheless, the fixative may alter dna integrity and the sample may be inadequate for hpv dna detection. the novaprep(®) vial test (nvt) (novacyt, vélizy-villacoublay, france) is a new device dedicated to lbc which permits an automated cell spreading over slides and an automated cell sampling for molecular analyses.201020884288
prevalence of high-risk human papillomavirus types and cervical squamous intraepithelial lesions in women over 30 years of age in st. petersburg, russia.cytology-based screening has significantly decreased incidence of and mortality from cervical cancer. high sensitivity of high-risk human papillomavirus (hrhpv) test for the detection of high-grade cervical intraepithelial neoplasia (cin) makes it a useful screening tool, especially in settings where cytology is not available or not quality assured. the study aimed to determine the prevalence of hrhpv and associated cervical lesions in russian women over 30 years of age and to assess usefulness ...201020884314
cutaneous hpv5 e6 causes increased expression of osteoprotegerin and interleukin 6 which contribute to evasion of uv-induced apoptosis.human papillomaviruses (hpvs) are small dna viruses, which specifically infect keratinocytes at different body sites. the association between cutaneous squamous cell carcinoma (scc) formation, ultraviolet (uv) irradiation and infection with a high-risk subset of cutaneous hpvs has been postulated although the underlying molecular mechanisms by which hpv may play a role in scc development are not yet fully elucidated. expression of the viral e6 oncoprotein has been shown to interfere with dna dam ...201020884685
off-label high-risk hpv dna testing of vaginal asc-us and lsil cytologic abnormalities at parkland hospital.to investigate the frequency and outcome of high-risk human papillomavirus (hpv) dna testing of atypical squamous cell of unknown significance (asc-us) and low-grade squamous intraepithelial lesion (lsil) vaginal thinprep pap tests (tppts).201020885164
apropos knowledge and attitudes of adult peruvian women vis-à-vis human papillomavirus, cervical cancer, and the human papillomavirus vaccine. 201020885172
asian society of gynecologic oncology workshop 2010.this workshop was held on july 31-august 1, 2010 and was organized to promote the academic environment and to enhance the communication among asian countries prior to the 2nd biennial meeting of australian society of gynaecologic oncologists (asgo), which will be held on november 3-5, 2011. we summarized the whole contents presented at the workshop. regarding cervical cancer screening in asia, particularly in low resource settings, and an update on human papillomavirus (hpv) vaccination was desc ...201020922136
factors associated with prevalent abnormal anal cytology in a large cohort of hiv-infected adults in the united states.the prevalence of and risk factors for abnormal anal cytology among men and women with human immunodeficiency virus (hiv) infection have not been extensively investigated.201020925532
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