Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [assessment of diagnostic prospects for a method of immunoenzyme analysis during mass testing of feces of patients for the purpose of detecting rotavirus antigens]. | 1989 | 2555970 | |
| enzyme polymorphism and clinical variability of diseases: a study of diabetes mellitus. | we investigated possible relations among four common neonatal manifestations of diabetic pregnancy (macrosomia, hypoglycemia, hypocalcemia, jaundice) and four enzyme polymorphisms (pgm1, ada, ak1, acp1 in a sample of infants born of diabetic mothers. the pattern of associations observed between the two sets of variables is consistent with known differences in enzymatic activity within phenotypes of each system, suggesting that low enzymatic activity may have unfavorable effects on fetal developm ... | 1989 | 2556341 |
| in vivo presynaptic modulation of serotonergic neurotransmission in the rat hippocampus by diazepam. | the effect of the benzodiazepine agonist, diazepam, on serotonergic (5-ht) neurotransmission was assessed in in vivo electrophysiological experiments. diazepam enhanced, in a dose-dependent manner (0.05-2 mg/kg i.v.), the effect of electrical stimulation of the ascending 5-ht pathway on the firing activity of dorsal hippocampus pyramidal neurons. this effect was blocked by the benzodiazepine antagonist, flumazenil. diazepam did not modify the efficacy of microiontophoretic application of 5-ht an ... | 1989 | 2559857 |
| [acute maternal anterior poliomyelitis in a non-endemic zone]. | the authors report the case of a 26 year old woman with acute anterior poliomyelitis contracted during the vaccination of her baby. despite having been herself vaccinated in infancy she was not protected against the poliovirus. the clinical interest of this uncommon case is a severe paralytic state with definitive paraplegia. the authors suggest serologic testing of patients born before 1967 especially if they are at risk of encountering the virus. | 1989 | 2561040 |
| characterization of l-glutamate action on the release of endogenous dopamine from the rat caudate-putamen. | in the present study the effect of l-glutamic acid (l-glu), n-methyl-d-aspartic acid (nmda), kainic acid (ka) and quisqualic acid (quis) on the release of endogenous dopamine (da) from slices of the rat caudate-putamen was investigated. da was measured by high-performance liquid chromatography coupled to an electrochemical detector. l-glu, nmda, ka and quis, in the absence of mg++, produced a dose-related, ca++-dependent increase in da release. the order of agonist efficacy was l-glu greater tha ... | 1989 | 2563769 |
| effect of endogenous opioid peptides on trh release from rat stomach in vitro. | the effect of endogenous opioid peptides (beta-endorphin, leucine-enkephalin, dynorphin 1-13 on the release of thyrotropin releasing hormone (trh) from the rat stomach in vitro was studied. the rat stomach was incubated in the medium 199 with 1.0 mg/ml of bacitracin (ph 7.4) (medium) and the amount of trh released into the medium was measured by radioimmunoassay. the release of trh from the rat stomach was inhibited significantly in a dose-related manner with the addition of endogenous opioid pe ... | 1989 | 2565806 |
| interleukin-6 in the epidermis of patients with psoriasis before and during puva treatment. | biopsies from lesional and unaffected skin of 6 patients with psoriasis, taken before and during treatment with psoralen plus uva (puva) were examined immunohistologically, using partially purified polyclonal antibodies to crude supernatants of activated human blood monocytes. by absorption with recombinant derived human monokines, we were able to demonstrate that interleukin-6 (il-6) (but not il-1 alpha or il-1 beta) was located in a laminar and granular pattern in stratum corneum, and on epide ... | 1989 | 2566221 |
| genome type analysis of adenoviruses: isolates from one year from the hannover area. | adenoviruses (av), isolated from 138 children during the year 1981 in the hannover area, were studied by dna restriction analysis with the enzymes bamhi, bglii, bsteii, ecori, hindiii, kpni, and smai and compared with the respective prototypes. varying fragment patterns were depicted and genome types analyzed. prototype-like strains of av1 and 5 were not found. types 2, 5, 1, 3, and 7 showed decreasing genetic variation in that order. altered restriction sites were physically mapped on the genom ... | 1989 | 2566302 |
| agonistic effects of anti-cd2 and anti-cd16 antibodies on human natural killer killing. | two monoclonal antibodies (moab), 9-1 (anti-cd2) and 3g8 (anti-cd16), were previously shown to enhance the cytotoxic activity of human natural killer (nk) cells. the present study examined the effect of 9-1 and 3g8 with different effector and target cells to determine whether they activate nk cells through a common mechanism. analysis of purified lymphocyte subpopulations demonstrated that the cd3+cd16+cd3- nk effector cell population is enhanced by both antibodies, while purified cd2+cd16-cd3+ ... | 1989 | 2567053 |
| long-range structure of h-ras 1-selected transgenomes. | we have used chromosome-mediated gene transfer (cmgt) and whole cell fusion to derive human-mouse hybrid cells carrying reduced human chromosomes 11, by selecting for expression of the transforming h-ras 1 oncogene. to realize the full potential of these somatic cell genetic techniques as resources for enriched dna probe isolation and the fine structure mapping of chromosomes, the nature of any molecular rearrangements that may accompany the process of dna transfer must be understood. we have an ... | 1989 | 2567060 |
| the cd2 antigen associates with the t-cell antigen receptor cd3 antigen complex on the surface of human t lymphocytes. | t lymphocytes can be activated by various stimuli directed either against the t-cell antigen receptor-cd3 antigen complex (ti-cd3) or the cd2 molecule; see ref. 1 for a review. activation signals generated by antigen binding to the antigen-specific alpha/beta heterodimer (ti) are thought to be transduced via the invariant cd3 gamma, epsilon and delta chains, and the associated zeta and eta subunits. the physiological role of the interaction of cd2 with its homologous cell-surface associated liga ... | 1989 | 2567497 |
| randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. | in a prospective study, 105 infants aged 3-12 months with acute otitis media were randomly assigned to one of three treatment groups: amoxycillin/clavulanate ('augmentin') alone (36 patients), myringotomy plus placebo (35 patients), or augmentin plus myringotomy (34 patients). the last two groups were double-blinded. bacterial pathogens, mainly haemophilus influenzae (of which 20% were beta-lactamase producers) and streptococcus pneumoniae, were isolated from 60% of the ear exudates and all isol ... | 1989 | 2567903 |
| assessment of pancreatic islet-cell population in the hyperglycemic athymic nude mouse: immunohistochemical, ultrastructural, and hormonal studies. | previous studies in diabetic animal models have demonstrated altered pancreatic islet-cell populations. to further characterize the diabetic syndrome in our athymic nude mouse colony, we studied the population of endocrine cells in pancreatic islets of 4-week-old normoglycemic and 8-week-old hyperglycemic athymic nude (nu/nu) mice using immunohistochemistry, morphometry, and electron microscopy. in normoglycemic 4-week athymic nu/nu mice, the proportions of b (insulin-secreting) cells and a (glu ... | 1989 | 2569196 |
| cloning and structural characterization of the genes coding for adenosylcobalamin-dependent methylmalonyl-coa mutase from propionibacterium shermanii. | the structural genes coding for both subunits of adenosylcobalamin-dependent methylmalonyl-coa mutase from the gram-positive bacterium propionibacterium shermanii have been cloned, with the use of synthetic oligonucleotides as primary hybridization probes. the genes are closely linked and are transcribed in the same direction. nucleotide sequence analysis of 4.5 kb of dna encompassing both genes allowed us to infer the complete amino acid sequence of the two subunits: the beta-subunit is the pro ... | 1989 | 2569861 |
| hydrogen peroxide mutagenicity towards salmonella typhimurium. | in bioassays conducted under controlled, comparable conditions, weak direct mutagenicity responses were observed for hydrogen peroxide in the standard (ames test) agar plate incorporation bioassay with salmonella typhimurium strains ta97, ta98, ta102, and ta1537, in a 20 min preincubation test with strains ta97, ta98, ta100, ta102, ta1537, and ta1538, and in a liquid incubation modification using strain ta1537. these results conclusively demonstrate that hydrogen peroxide is a weak mutagen, espe ... | 1989 | 2572065 |
| bacteroides loeschei pk1295 cells express two distinct adhesins simultaneously. | bacteroides loeschei synthesizes two distinct adhesins that mediate its coaggregation with streptococcus sanguis 34 and actinomyces israeli pk14. streptococcal adhesin-specific and actinomyces adhesin-specific monoclonal antibodies were used to prepare antibody-coated 5- or 10-nm gold particles. these were used in immunoelectron microscopic studies to establish that essentially all bacteroides cells in a population express both adhesins. in general, the two sizes of gold particles representing e ... | 1989 | 2572563 |
| influence of infused beta-adrenergic agonists on porcine blood metabolites and catecholamines. | anesthetized pigs were infused sequentially with increased concentrations of beta-adrenergic agonists. at selected times during infusion, blood pressure, heart rate and plasma concentrations of free fatty acids (ffa), glycerol, glucose, lactate, norepinephrine, epinephrine and dopamine were measured. azaperone, a drug used to calm the pigs before anesthesia, caused hypotension and bradycardia but did not affect plasma metabolites. infusion of norepinephrine, epinephrine, isoproterenol or clenbut ... | 1989 | 2572576 |
| restriction fragment length polymorphism of the human insulin receptor gene among mexican americans. | recently, we examined a restriction fragment length polymorphism (rflp) at the insulin receptor locus in mexican americans. this rflp can be detected using the restriction endonuclease rsa i, and has three alleles of 3.4 kb, 6.2 kb, and 6.7 kb. our data suggested that the 3.4 kilobase pair (kb) allele may be associated with type ii (non-insulin dependent) diabetes mellitus in mexican americans. we initiated studies to identify additional polymorphisms at the insulin receptor locus that might be ... | 1989 | 2573118 |
| modulation of the autonomic control of the failing heart. | the failing heart operates with an abnormal combination of heart rate, stroke volume, and enddiastolic volume. this mismatch becomes more evident during exercise of patients with heart failure, when an increase in cardiac output is achieved with higher heart rate, a lower stroke volume and a higher enddiastolic volume. using the beta 1-adrenoceptor partial agonist xamoterol which lacks beta 2-adrenoceptor agonism the response of the heart to sympathetic stimulation can be modulated. at rest and ... | 1989 | 2573339 |
| on the mechanism of positive inotropic effects of alpha-adrenoceptor agonists. | the positive inotropic effect of the alpha 1-adrenoceptor agonist phenylephrine is accompanied by an increase in the presumed second messengers inositol 1,4,5-trisphosphate (1,4,5-ip3) and inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-ip4). both 1,4,5-ip3 and 1,3,4,5-ip4 sensitize myocardial contractile proteins in chemically skinned fibers. in addition to the ca++ releasing effect of 1,4,5-ip3 from the sarcoplasmic reticulum the ca++-sensitizing effect of the inositol phosphates may play a role i ... | 1989 | 2573342 |
| glutamine synthetase and glutaminase activities in various hepatoma cells. | glutamine synthetase and glutaminase activities in a series of hepatoma cells of human and rat origins were determined for comparison with normal liver tissues. marked decrease in glutamine synthetase activity was observed in the tumor cells. phosphate-dependent and phosphate-independent glutaminase activities were increased compared with those from normal liver tissues. well coupled mitochondria were isolated from huh 13 line of human hepatoma cells and human liver. oxypolarographic tests showe ... | 1989 | 2573354 |
| structure-activity relationships as a response to the pharmacological differences in beta-receptor ligands. | with a few notable exceptions, beta-receptor ligands (agonists and antagonists) belong to the aryl- or heteroaryl-ethanolamine series and to the aryl- or heteroaryl-oxypropanolamine series. structure-activity relationships for beta-adrenergic agonists show that a secondary amine in the phenylethanolamine side chain ending is essential for receptor stimulation. the 3,4-dihydroxyphenyl groups may be replaced by "phenol equivalents" (-ch2oh, -nhconh2, -choh, -nhso2ch3). in contrast, substitution at ... | 1989 | 2573372 |
| [effects of bombesin on gastrin, somatostatin, glucagon and acid secretion from isolated rat stomach in vitro]. | effects of bombesin on the secretion of gastric acid and gastro-intestinal hormones were investigated in isolated perfused rat stomach. bombesin (intra-arterial, 2 x 10(-10) mol/l, 0.3 ml/min) stimulated gastric acid secretion from basal 2.50 +/- 0.05 x 10(-1) to 8.40 +/- 1.50 x 10(-1) meq/min (p less than 0.001). exogenous addition of pentagastrin did not potentiate this effect of bombesin. bombesin induced twice releasing of gastrin and somatostatin in portal effluent but inhibited glucagon se ... | 1989 | 2574916 |
| central and peripheral actions of alpha 2-adrenergic agonists on renal function in long-evans and brattleboro rats. | the effects of 3 alpha 2-adrenergic receptor agonists on renal function in vasopressin (avp)-deficient brattleboro (di) rats were evaluated. the aim of this study was to determine the relative contribution of central versus peripheral alpha 2-adrenoceptors in mediating diuresis and natriuresis, as well as the role of alpha 2-adrenoceptors in antagonizing the actions of avp. in addition to the studies of renal function, the effects of avp deficiency on renal alpha 2-adrenoceptor affinity and numb ... | 1989 | 2575260 |
| study of the negative inotropic action of somatostatin. | somatostatin was evaluated as a chronotropic and inotropic agent in isolated, spontaneously beating guinea-pig atria. somatostatin (3 x 10(-5)-1 x 10(-3) mm) caused a concentration-dependent negative inotropic effect and a small reduction of atrial rate. the negative inotropic effect of somatostatin was evaluated at different concentrations of extracellular calcium, on the positive inotropic response induced by calcium and on the positive chronotropic response induced by adrenaline. small, nonsi ... | 1989 | 2575886 |
| immunoglobulin m, a, and g antibody response to lipopolysaccharide o antigen in symptomatic and asymptomatic shigella infections. | the antilipopolysaccharide antibody response in sera obtained from subjects involved in 10 outbreaks of shigellosis occurring in israeli military field units was determined by an enzyme-linked immunosorbent assay and a passive hemagglutination test. both tests were found to be sensitive and specific for the diagnosis of shigellosis. a significant antibody response was detected in 73 to 82% of the symptomatic and 48 to 60% of the asymptomatic subjects during the shigella sonnei and shigella flexn ... | 1989 | 2463995 |
| [comparative diagnostic value of methods for detecting dysentery antigens in substrates of the patient's body]. | the comparative evaluation of different immunological methods, such as the enzyme immunoassay, the aggregate hemagglutination test and the complement fixation test, used for the detection of specific shigella antigens in biological body substrates obtained from 287 patients with acute dysentery caused by s. sonnei, s. flexneri and s. newcastle has been carried out. the enzyme immunoassay and the aggregate hemagglutination test most effective (97.5 +/- 0.5 and 92.4 +/- 0.9, respectively), the obj ... | 1989 | 2469267 |
| reducing the illegal sale of cigarettes to minors. | this study reports on an effort to stop the illegal sale of cigarettes to minors. in santa clara county, calif, 412 stores and 30 vending machines were visited by 18 minors aged 14 through 16 years with the intent to purchase cigarettes; they were successful at 74% of the stores and 100% of the vending machines. after an aggressive six-month campaign using communitywide media, direct merchant education, contact with the chief executive officers of chain stores and franchise operations owned by m ... | 1989 | 2908999 |
| effect of aging on populations of estrogen receptor-containing cells in the rat uterus. | estrogen receptor-containing cells were identified in uteri of mature and senescent rats by means of quantitative autoradiography. cell numbers and density were assessed in the various uterine layers. it was determined that despite decreases in receptor concentrations in endometrium, endometrial stroma, myometrium, and epithelium, no significant cell loss occurred in any region. receptor content per cell clearly decreased with age in the endometrial stroma, while only in the myometrium was there ... | 1989 | 2909390 |
| protective role of serum antibody in immunity to chlamydial genital infection. | female guinea pigs were injected intraperitoneally with pooled immunoglobulin derived from animals immunized to the chlamydial agent of guinea pig inclusion conjunctivitis. genital infections in animals receiving pooled immunoglobulin from immune animals were markedly decreased with regard to the number of inclusions detected compared with control animals. these data indicated that serum-derived antibody was able to provide a degree of protection against a chlamydial genital tract infection. | 1989 | 2909492 |
| newer techniques of laryngeal reinnervation. | we relate the experience obtained in the use of the right superior laryngeal nerve (motor branch)--cricothyroid muscle pedicle flap in dogs in an attempt to reinnervate the right posterior cricoarytenoid muscle (pca). the right vocal cord was paralyzed by severance and removal of 2.5 cm of the right recurrent laryngeal nerve. evaluation 6 months postoperatively revealed the vocal fold remobilization on the right side to have an average of about one half the mobility of the left, normal side. aft ... | 1989 | 2910195 |
| polyclonal anti-idiotypes influence macrophage chemotaxis in coxsackievirus-induced murine myocarditis. | investigation into the mechanism(s) whereby monocytes-macrophages are mobilized to the myocardium of coxsackievirus (cvb3)-infected mice was approached by assessing the role of anti-idiotypic antibodies against specific antiviral igg molecules. balb/c mice preinoculated with polyclonal anti-idiotypic, syngeneic antibodies resulted in significantly decreased myocarditis after virus challenge. on the other hand, oil-induced peritoneal exudate cells obtained from virus-exposed animals demonstrated ... | 1989 | 2911021 |
| polyamines are sufficient to drive the transport of the precursor of ornithine carbamoyltransferase into rat liver mitochondria: possible effect on mitochondrial membranes. | the polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. the presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, suggesting a possible role of these molecules in the transport of the precursor of ornithine carbamoyltransferase into mitochondria, by the formation and/or stabilization of mitochon ... | 1989 | 2912450 |
| failure of vitamin e to protect the retina against damage resulting from bright cyclic light exposure. | cumulative light-mediated damage to the retina over a long time period may be involved in the development of age-related retinopathies. light is thought to produce retinal damage by initiating autoxidative reactions among the molecular components of the retina. experiments were therefore conducted (1) to confirm that long-term differences in cyclic light intensity affect the rate of age-related photoreceptor cell loss from the retina; and (2) to determine whether the antioxidant, vitamin e, is a ... | 1989 | 2912912 |
| aplysia synaptosomes. i. preparation and biochemical and morphological characterization of subcellular membrane fractions. | we prepared and characterized subcellular membrane fractions from the cns of aplysia californica that are enriched in isolated nerve terminals (synaptosomes). ganglia were homogenized in 1.1 m sucrose and fractionated on a 2-step sucrose gradient, yielding 50 micrograms protein/animal in the synaptosomal fraction (p3), which was enriched 3-fold in plasma membrane as compared with the initial homogenate. quantitative morphometry of electron micrographs revealed that p3 contained 25% intact synapt ... | 1989 | 2913212 |
| improved sexual function in hemodialysis patients on recombinant erythropoietin: a possible role for prolactin. | as it was reported that correction of anemia in long-term hemodialysis patients by recombinant human erythropoietin (r-huepo) is associated with improved sexual function, we conducted the present study to further delineate the mechanism(s) by which this is brought about. serum prolactin, testosterone, and parathyroid hormone (pth) levels were followed during 4 months of r-huepo therapy. within 4 months of treatment with r-huepo, hematocrit values rose from 23.7 +/- 1.2 to 35.7 +/- 0.2% and hemog ... | 1989 | 2914405 |
| the protective effect of thromboxane synthetase inhibition on renal function in systemic sepsis. | to study the role of thromboxane in systemic sepsis and renal failure, peritonitis was induced surgically in 22 sheep, leading to local and systemic sepsis. a selective thromboxane synthetase inhibitor, u63,557a (upjohn co, kalamazoo, mi) was given before surgery in five animals and 30 minutes after surgery in five animals. a typical picture of volume-loaded, normotensive, vasodilated septic shock developed in all animals. twenty four hours after induction of sepsis, the control group showed a m ... | 1989 | 2916566 |
| ph-dependent uptake and macrofilaricidal effects of chloroquine on adult filarial parasites in vitro. | uptake and macrofilaricidal effects of chloroquine (cq) and other aminoquinolines were found to be highly ph dependent in brugia pahangi, acanthocheilonema viteae, onchocerca volvulus, and dirofilaria immitis. using [3h]cq, it was found that all of the parasites took up more drug under alkaline conditions (rpmi 1640 at ph 8.4) than in neutral (ph 7.4) or acidic (ph 6.8) media. differences were seen in the amount of drug taken up among the filariae studied. b. pahangi and a. viteae took up 7 time ... | 1989 | 2917628 |
| hepatic structural correlates of liver fibrosis: a morphometric analysis. | liver fibrosis is an important feature of many liver diseases, and the assessment of fibrosis is essential for diagnosis and prognosis. liver needle biopsy, however, tends to sample preferentially the soft parenchyma, which poorly reflects the true extent of fibrosis. therefore, we have searched for capsule and parenchymal features that are correlated with the fibrosis. to test for these correlations, we used a morphometric analysis of a rat model of liver fibrosis. we demonstrated that, of the ... | 1989 | 2920817 |
| degradation of type ix collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells. | the degradation of type ix collagen, a minor collagen in cartilage, was examined by treatment with three different types of matrix metalloproteinases (mmps) purified from the culture medium of rheumatoid synovial cells. neither mmp-1 (collagenase) nor mmp-2 (so-called 'gelatinase') could digest type ix collagen, but mmp-3 (stromelysin) readily degraded it into smaller fragments. this suggests that mmp-3 may be responsible for the pathological degradation and/or normal turnover of type ix collage ... | 1989 | 2920840 |
| sensitivity of campylobacter pylori to colloidal bismuth subcitrate. | 1989 | 2921366 | |
| chronic colitis after aeromonas infection. | 1989 | 2583575 | |
| some trematodes of freshwater fishes from north vietnam with a list of recorded endohelminths by fish hosts. | the present paper comprises a systematic survey of trematodes collected from 12 species of freshwater fishes from north vietnam (the red river near hanoi). altogether 16 trematode species (14 adults and 2 juvenile forms) have been recorded. these include: amurotrema dombrowskajae, platycladorchis microacetabularis, p. macroacetabularis, neocladorchis multilobularis, carassotrema koreanum, azygia hwangtsiyui, phyllodistomum clariasi, phyllodistomum sp., orientocreadium batrachoides, masenia colla ... | 1989 | 2583614 |
| route of delivery of phenylalanine influences its effect on short-term food intake in adult male rats. | the effect of phenylalanine (phe) on plasma and brain phe and tyrosine (tyr) levels and on short-term food intake in male rats was measured after intragastric (i.g.), subcutaneous (s.c.) and intraperitoneal (i.p.) administration. compared to equimolar alanine (ala), which served as the control, phe significantly suppressed feeding at a dose of 90 mg/kg body wt when given i.p., but doses up to 720 mg/kg body wt had no effect when given i.g. or s.c. the high doses of phe given by the i.g. or s.c. ... | 1989 | 2585142 |
| expression and desensitisation of a2 purinoceptors on cultured bovine aortic endothelial cells. | purine nucleotides and their metabolites are important mediators of vascular tone. adenosine promotes relaxation of vascular smooth muscle, acting on the a2 subclass of purinoceptors. there is some evidence that these receptors are also present on vascular endothelial cells. we have therefore examined cultured aortic endothelial cells for adenosine (a2) sensitivity. bovine aortic endothelial cells (ag4762) were obtained from the institute of aging cell repository (usa), and cultured in monolayer ... | 1989 | 2590913 |
| recovery of proteins and peptides with nanogram loads on non-porous packings. | 1989 | 2592499 | |
| causes of death and the histopathologic findings in fatal shigellosis. | thirty-seven children (median age, 2 years) with shigellosis in bangladesh were subjected to postmortem examination to determine causes of death and the spectrum of intestinal histopathology. infecting species were: shigella dysenteriae 1, 7 cases; s. dysenteriae 2, 2 cases; shigella flexneri, 23 cases; shigella boydii, 4 cases; and mixed infection with shigella boydii and shigella sonnei, 1 case. complicating conditions detected before death included malnutrition in 25 cases, pneumonia in 11 ca ... | 1989 | 2594452 |
| differential blocking effects of atropine and gallamine on negative chronotropic and dromotropic responses to vagus stimulation in anesthetized dogs. | the negative dromotropic response to cervical vagus stimulation was inhibited less than the negative chronotropic response to cervical vagus stimulation by the same dose of atropine in neurally decentralized, anesthetized dogs. atropine and gallamine bind different muscarinic binding sites. we thus investigated the blocking effects of atropine and gallamine on the negative chronotropic and dromotropic responses to stimulation of the vagus nerves. we stimulated the intracardiac vagus nerves to th ... | 1989 | 2600814 |
| rheumatoid synovial fluid reconstitutes the b-cell defect in cba/n mice. | synovial fluid from patients with rheumatoid arthritis (ra-sf) contains a biological activity which can replace t cells for activation of antibody secretion in human blood lymphoid cells and which can also induce the selective differentiation of igg2b-secreting cells in lipopolysaccharide (lps)-pre-activated mouse spleen cells. the b-cell activity of this factor was studied in cba/n mice which have an x-linked b-cell immunodeficiency which manifests itself as a defective humoral response to cert ... | 1989 | 2602914 |
| cardiopulmonary baroreflex control of brachial artery diameter in sustained essential hypertension. | an exaggerated reflex response of forearm resistance vessels following stimulation of cardiac mechanoreceptors has been observed in human hypertension. in the present study we analyze the possibility that such an increased response also involves the large brachial artery. for that purpose, the influence of leg elevation in subjects in a supine position on brachial artery diameter and blood flow velocity was studied in 12 healthy, normal males and 17 males of the same age with sustained essential ... | 1989 | 2607141 |
| signal structure of the cis-acting element recognized by virg protein, a positive regulator in agrobacterium. | virg protein is known to be the positive regulator for vir genes of ri and ti plasmids in agrobacterium. to investigate the cis-acting element recognized by virg, we have determined the transcriptional start points of the vir genes on ri plasmid (pria4b). from the analysis of the upstream sequences, it has been found that the sequences generally similar to 5'tg(a/t)aa(c/t)3' appear in phase with an 11-base pair interval, and that the -35 and -10 regions of the promoters are located nearly in the ... | 1989 | 2608465 |
| symptoms associated with diarrhoeal illness at san lazaro hospital, manila in 1983 and 1984. | the clinical features associated with various agents of diarrhoeal disease were studied using 2,836 patients admitted to san lazaro hospital, manila. three general patient groups were considered including single pathogen isolations, "multiple pathogen" isolations, and "no pathogen" isolations. in general, symptoms of diarrhoeal illness were found to be non-specific. however, shigella flexneri. vibrio parahemolyticus, and rotavirus were significantly associated with a number of prominent symptoms ... | 1989 | 2609210 |
| three dimensional observations of the palisade-shaped nerve endings of normal hair of rat's snout. | the nerve endings of normal hair of the rat's snout, partially digested with trypsin and hydrochloric acid, were studied by scanning electron microscopy. each lanceolate structure measured ca. 10 microns in length and was arranged around the hair follicle. these palisade-shaped nerve endings were situated almost beneath the sebaceous glands, ran upward, parallel to the axis of the hair follicle, and terminated in pointed shape. 2 kinds of cells, teloglia cell type i showing flat profile, and tel ... | 1989 | 2610376 |
| studies on acute toxic effects to keratinocytes induced by hematoporphyrin derivatives and laser light. | human epidermal keratinocytes were grown in culture and the uptake of hematoporphyrin derivatives (hpds) used in photodynamic therapy was estimated. keratinocytes loaded with hpds were irradiated with laser light of 632 nm generated by a helium-neon laser and cell toxicity was determined by the trypan blue exclusion test and the measurement of enzyme release. with increasing intracellular concentration of hpds and with increasing intensity of the laser light, an increasing number of cells took u ... | 1989 | 2610520 |
| ecotoxicological characterization of industrial wastewater--sulfite pulp mill with bleaching. | different process wastewaters from a sulfite pulp mill with bleaching were characterized by chemical analysis and toxicity tests. the amount of adsorbable organically bound halogen (aox) from the bleachery was 3.6 kg per ton pulp. the extractable organically bound chlorine was 15% of aox. some identified organochlorine compounds in the effluent could be traced in the receiving water. effluents from the chlorination and alkaline extraction stages and the condensate were the main contributors to t ... | 1989 | 2612424 |
| ecotoxicological characterization of industrial wastewater--sulfite pulp mill with bleaching. | different process wastewaters from a sulfite pulp mill with bleaching were characterized by chemical analysis and toxicity tests. the amount of adsorbable organically bound halogen (aox) from the bleachery was 3.6 kg per ton pulp. the extractable organically bound chlorine was 15% of aox. some identified organochlorine compounds in the effluent could be traced in the receiving water. effluents from the chlorination and alkaline extraction stages and the condensate were the main contributors to t ... | 1989 | 2612424 |
| effects of postnatal dexamethasone treatment on development of alveoli in adult rats. | we compared the effects of dexamethasone given to rats from age 4 to 14 days, on alveolar development at age 99 days. judged by similar nose-to-tail length and body weight, somatic growth was not altered by dexamethasone treatment. lung volumes in both air- and saline-filled lungs and mean chord length (lm) were increased, whereas alveolar surface area (sa) and surface-to-volume ratio (s/v) were diminished in dexamethasone-treated adult rats. these changes were associated with a significant redu ... | 1989 | 2612450 |
| effects of postnatal dexamethasone treatment on development of alveoli in adult rats. | we compared the effects of dexamethasone given to rats from age 4 to 14 days, on alveolar development at age 99 days. judged by similar nose-to-tail length and body weight, somatic growth was not altered by dexamethasone treatment. lung volumes in both air- and saline-filled lungs and mean chord length (lm) were increased, whereas alveolar surface area (sa) and surface-to-volume ratio (s/v) were diminished in dexamethasone-treated adult rats. these changes were associated with a significant redu ... | 1989 | 2612450 |
| pathophysiological variations in the rat liver plasma membrane serine proteinase activity. | the effects of fasting, diabetes, cholestasis, two-third hepatectomy and adrenalectomy on the rat liver plasma membrane serine proteinase activity were studied. our results show a significant decrease of the enzyme activity during fasting (-50%), during experimental diabetes (-50%), in regenerating liver after partial hepatectomy (-70%) and after extrahepatic cholestasis (-70%). no modifications are noted when the rats are bilaterally adrenalectomized. these findings suggest that the enzyme acti ... | 1989 | 2612451 |
| pathophysiological variations in the rat liver plasma membrane serine proteinase activity. | the effects of fasting, diabetes, cholestasis, two-third hepatectomy and adrenalectomy on the rat liver plasma membrane serine proteinase activity were studied. our results show a significant decrease of the enzyme activity during fasting (-50%), during experimental diabetes (-50%), in regenerating liver after partial hepatectomy (-70%) and after extrahepatic cholestasis (-70%). no modifications are noted when the rats are bilaterally adrenalectomized. these findings suggest that the enzyme acti ... | 1989 | 2612451 |
| characterization of excretory-secretory proteins synthesized in vitro by schistosoma mansoni primary sporocysts. | excretory-secretory (e-s) products released by larval schistosomes have been implicated in the interference of host snail defense systems. because of the potentially important role that e-s products play in the parasite-host relationship, total and newly synthesized e-s proteins from in vitro-cultured schistosoma mansoni primary sporocysts were characterized using incorporation of [35s]methionine followed by sodium dodecylsulfate polyacrylamide gel electrophoresis (sds-page) and fluorography. to ... | 1989 | 2614597 |
| indomethacin blocks the anorexic action of interleukin-1. | it has been reported recently that the central nervous system actions of interleukin-1 are mediated by the prostaglandin system in the brain. the present study was therefore performed in order to examine the hypothesis that indomethacin, an inhibitor of prostaglandin biosynthesis, might alleviate the interleukin-1-induced suppression of food intake in rats. the i.p. injection of interleukin-1 (2 micrograms/rat) resulted in a significant decrease in food intake. the pre-injection of indomethacin ... | 1989 | 2620696 |
| indomethacin blocks the anorexic action of interleukin-1. | it has been reported recently that the central nervous system actions of interleukin-1 are mediated by the prostaglandin system in the brain. the present study was therefore performed in order to examine the hypothesis that indomethacin, an inhibitor of prostaglandin biosynthesis, might alleviate the interleukin-1-induced suppression of food intake in rats. the i.p. injection of interleukin-1 (2 micrograms/rat) resulted in a significant decrease in food intake. the pre-injection of indomethacin ... | 1989 | 2620696 |
| synaptonemal complex analysis of hybrid cattle. i. pachytene substaging and the normal full bloods. | meiotic chromosome pairing abnormalities in full-blood and hybrid bos taurus and b. indicus cattle have been surveyed by electron microscopy of pachytene synaptonemal complex spreads. in this paper the full-blood spreads are described in detail, including the use of xy and nucleolar morphology and other measured parameters for pachytene substaging. pairing abnormalities were observed in up to 9% of the full-blood spreads. most of these pairing abnormalities (83%) occurred in early-pachytene spre ... | 1989 | 2620818 |
| synaptonemal complex analysis of hybrid cattle. i. pachytene substaging and the normal full bloods. | meiotic chromosome pairing abnormalities in full-blood and hybrid bos taurus and b. indicus cattle have been surveyed by electron microscopy of pachytene synaptonemal complex spreads. in this paper the full-blood spreads are described in detail, including the use of xy and nucleolar morphology and other measured parameters for pachytene substaging. pairing abnormalities were observed in up to 9% of the full-blood spreads. most of these pairing abnormalities (83%) occurred in early-pachytene spre ... | 1989 | 2620818 |
| [experimental and clinical studies on the exclusion and bypassing operation for abdominal aortic and iliac artery aneurysms]. | for the purpose of simplifying operative techniques and decreasing operative risks, we evaluated excusion and bypassing operation for infrarenal abdominal aortic and iliac artery aneurysm (aaa) both experimentally and clinically. this method includes dissection and closure of proximal stump of the aneurysm and anatomical bypass technique in principle. in the experiments, the ratio of internal pressure of the excluded aorta (e.ao) to systemic blood pressure (e.p.i.) was 0.62 +/- 0.03 (n = 7, mean ... | 1989 | 2626156 |
| [experimental and clinical studies on the exclusion and bypassing operation for abdominal aortic and iliac artery aneurysms]. | for the purpose of simplifying operative techniques and decreasing operative risks, we evaluated excusion and bypassing operation for infrarenal abdominal aortic and iliac artery aneurysm (aaa) both experimentally and clinically. this method includes dissection and closure of proximal stump of the aneurysm and anatomical bypass technique in principle. in the experiments, the ratio of internal pressure of the excluded aorta (e.ao) to systemic blood pressure (e.p.i.) was 0.62 +/- 0.03 (n = 7, mean ... | 1989 | 2626156 |
| increased erythrocyte adenosine deaminase activity in children with perinatal human immunodeficiency virus infection. | erythrocyte adenosine deaminase (ada) activity was assessed in 33 children born to human immuno-deficiency virus (hiv)-positive mothers. the enzyme values were significantly increased in infected, symptom-free children compared with a control group of hiv-negative subjects (mean +/- sd: 0.34 +/- 0.01 unit/ml red blood cells (rbc) vs. 0.25 +/- 0.04 unit/ml rbc, p less than 0.01) and a further significant increase was found in symptomatic children (0.45 +/- 0.02 unit/ml rbc, p less than 0.01 vs. i ... | 1989 | 2626286 |
| [effects of smoking on human health]. | in this study, 30 cases of male smokers aged 35.7 +/- 5.2 years mean and 30 male nonsmokers aged 36.6 +/- 6.8 years were selected from a factory. before the assay, everyone smoked one pack of cigarette in a day, after that these tests were done. the experimental results as follows. 1. comparing with control group, the levels of igg and igm in serum of smoking group are lower. it was shown that smoking has an inhibitive effect on phagocytosis and bactericidal of am, so smoking has a damaging and ... | 1989 | 2632033 |
| [effects of smoking on human health]. | in this study, 30 cases of male smokers aged 35.7 +/- 5.2 years mean and 30 male nonsmokers aged 36.6 +/- 6.8 years were selected from a factory. before the assay, everyone smoked one pack of cigarette in a day, after that these tests were done. the experimental results as follows. 1. comparing with control group, the levels of igg and igm in serum of smoking group are lower. it was shown that smoking has an inhibitive effect on phagocytosis and bactericidal of am, so smoking has a damaging and ... | 1989 | 2632033 |
| superoxide dismutase activity in some strains of lactobacilli: induction by manganese. | dialyzed cell-free extract of lactobacilli was found to contain superoxide dismutase activity by using a test system in which superoxide ion is generated by xanthine oxidase. the specific activities of lactobacillus acidophilus atcc 4356, lactobacillus murinus atcc 35020, lactobacillus acidophilus crl 358, lactobacillus plantarum atcc 8014, lactobacillus casei crl 431, lactobacillus plantarum crl 353, lactobacillus fermentum atcc 9338, lactobacillus buchneri ncdo 110, and lactobacillus fermentum ... | 1989 | 2632048 |
| superoxide dismutase activity in some strains of lactobacilli: induction by manganese. | dialyzed cell-free extract of lactobacilli was found to contain superoxide dismutase activity by using a test system in which superoxide ion is generated by xanthine oxidase. the specific activities of lactobacillus acidophilus atcc 4356, lactobacillus murinus atcc 35020, lactobacillus acidophilus crl 358, lactobacillus plantarum atcc 8014, lactobacillus casei crl 431, lactobacillus plantarum crl 353, lactobacillus fermentum atcc 9338, lactobacillus buchneri ncdo 110, and lactobacillus fermentum ... | 1989 | 2632048 |
| ozagrel hydrochloride monohydrate, a thromboxane synthase inhibitor, and its metabolites as inhibitors of hepatic microsomal drug metabolism. | the change in the hepatic oxidative drug-metabolizing capacity in humans treated with ozagrel hydrochloride monohydrate (oza), an imidazole derivative and a new thromboxane a2 synthase inhibitor, was studied and the inhibitory potencies of the metabolites of oza (m-1 and m-2) on the mouse hepatic microsomal monooxygenase system in vitro were compared with that of oza. in vitro, m-1 and m-2, which are the beta-oxidized form and the reduced form of oza, respectively, inhibited aminopyrine n-demeth ... | 1989 | 2632083 |
| ozagrel hydrochloride monohydrate, a thromboxane synthase inhibitor, and its metabolites as inhibitors of hepatic microsomal drug metabolism. | the change in the hepatic oxidative drug-metabolizing capacity in humans treated with ozagrel hydrochloride monohydrate (oza), an imidazole derivative and a new thromboxane a2 synthase inhibitor, was studied and the inhibitory potencies of the metabolites of oza (m-1 and m-2) on the mouse hepatic microsomal monooxygenase system in vitro were compared with that of oza. in vitro, m-1 and m-2, which are the beta-oxidized form and the reduced form of oza, respectively, inhibited aminopyrine n-demeth ... | 1989 | 2632083 |
| long residual activity of bacillus sphaericus 1593 against culex quinquefasciatus larvae in artificial pools. | the microbial larvicide, bacillus sphaericus 1593, was evaluated against culex quinquefasciatus larvae in artificial pools at huay kwang area in bangkok between march and october 1985. this study was aimed at determining the residual activity of b. sphaericus 1593 in waste water under field conditions. the larvicidal activity of b. sphaericus 1593 was found to persist for at least 5 months in artificial pools containing waste water. the populations of b. sphaericus 1593 in the test water fluctua ... | 1989 | 2633350 |
| distribution, oxygenation, and clonogenicity of macrophages in a murine tumor. | transplantable murine tumors, such as the squamous cell carcinoma growing in c3h mice, include a significant proportion of normal cells. the nature of these cells, their locations relative to the blood supply, their oxygenation status, and ability to incorporate 3h-thymidine were examined by sorting cells staining positive or negative with fluorescein isothiocyanate-conjugated goat antimouse igg. of the cells that were recovered from this tumor, 39% +/- 19 (n = 25) were igg+ cells, and this perc ... | 1989 | 2639726 |
| molecular studies of human response to allergens. | 1989 | 2639765 | |
| recurrent shigellosis complicating human immunodeficiency virus infection: failure of pre-existing antibodies to confer protection. | 1989 | 2642653 | |
| clinical applications of recombinant human colony-stimulating factors. | the differentiation and maturation of hematopoietic progenitor cells are regulated by certain growth factors. several of these glycoproteins have been characterized, and their amino acid sequences have been delineated. modern dna technology provides sufficient quantities of these hormones for testing in clinical trials. erythropoietin (epo) has been shown to increase the hemoglobin level and hematocrit in patients with end-stage renal disease. granulocyte colony-stimulating factor (g-csf) and gr ... | 1989 | 2642725 |
| intracellular spread of shigella flexneri associated with the kcpa locus and a 140-kilodalton protein. | escherichia coli k-12 hybrids carrying both the 220-kilobase plasmid and the pure-linked kcpa locus from shigella flexneri expressed a 140-kilodalton (kda) protein which was recognized by convalescent sera from monkeys infected with s. flexneri. these hybrids were tested for the ability to produce plaques in hela cell monolayers. hybrid strains which carried both the 220-kilobase plasmid and the kcpa locus had a plaque-forming efficiency of at least 10(-4) pfu/cfu, whereas the plaque-forming eff ... | 1989 | 2643571 |
| characterization of opiate binding sites on membranes of rat lymphocytes. | in view of the importance of membrane receptors for the interconnection between the central nervous system and the immune system, we carried out a study to characterize opiate binding sites on membranes of rat lymphocytes. we found that mitogen-activated spleen cells, but not thymocytes, possess specific and displaceable binding sites for [3h]naloxone. the binding was equally effective and intense while using b-cell-depleted spleen cells. the binding showed two sites of saturation, one at 10 nm ... | 1989 | 2643626 |
| characterization of opiate binding sites on membranes of rat lymphocytes. | in view of the importance of membrane receptors for the interconnection between the central nervous system and the immune system, we carried out a study to characterize opiate binding sites on membranes of rat lymphocytes. we found that mitogen-activated spleen cells, but not thymocytes, possess specific and displaceable binding sites for [3h]naloxone. the binding was equally effective and intense while using b-cell-depleted spleen cells. the binding showed two sites of saturation, one at 10 nm ... | 1989 | 2643626 |
| invasion of vero cells by salmonella species. | the invasiveness of salmonella strains for vero cells was studied by quantitative bacteriology; the technique was more sensitive than phase contrast microscopy. all of 59 salmonella strains, of 19 different serotypes, were more invasive than escherichia coli k12. three strains of shigella were as invasive as most of the salmonella strains whereas 29 strains of e. coli, two of proteus, three of klebsiella and one of serratia were much less invasive. two citrobacter strains exhibited intermediate ... | 1989 | 2643706 |
| virg, a plasmid-coded virulence gene of shigella flexneri: identification of the virg protein and determination of the complete coding sequence. | on the 230-kilobase-pair (kb) virulence plasmid of shigella flexneri 2a strain ysh6000, at least seven separate genetic determinants have been identified. one of them, an approximately 4-kb region, virg, that is required for the sereny reaction, was extensively studied to examine the role of the virg region. the phenotype of a virg- mutant (m94) of ysh6000 in the cytoplasm of cultured mk cells was characterized by a kinetic study of the invading shigellae. the observed phenotype of m94 in the cy ... | 1989 | 2644195 |
| chronic shigella flexneri infection preceding development of acquired immunodeficiency syndrome. | shigella sp. is known to be an important cause of diarrhea in homosexual men, although chronic infection is infrequently recognized. we describe recurrent and relapsing symptomatic infection due to shigella flexneri in a human immunodeficiency virus-infected homosexual man subsequently developed acquired immunodeficiency syndrome. patients with acquired immunodeficiency syndrome may be prone to developing chronic shigellosis because of impaired intestinal cell-mediated immunity. | 1989 | 2644299 |
| shigellosis and aids. report of a case and brief review of the literature. | this report describes the fatal outcome of an infection with shigella flexneri in a 39-yr-old man with the acquired immunodeficiency syndrome (aids). the pertinent literature is reviewed. | 1989 | 2644558 |
| ketopantoyl-lactone reductase from candida parapsilosis: purification and characterization as a conjugated polyketone reductase. | ketopantoyl-lactone reductase (2-dehydropantoyl-lactone reductase, ec 1.1.1.168) was purified and crystallized from cells of candida parapsilosis ifo 0708. the enzyme was found to be homogeneous on ultracentrifugation, high-performance gel-permeation liquid chromatography and sds-polyacrylamide gel electrophoresis. the relative molecular mass of the native and sds-treated enzyme is approximately 40,000. the isoelectric point of the enzyme is 6.3. the enzyme was found to catalyze specifically the ... | 1989 | 2644973 |
| role of m cells in initial antigen uptake and in ulcer formation in the rabbit intestinal loop model of shigellosis. | strains of shigella flexneri with different invasive and pathogenic potentials were inoculated into the intestinal lumen of acutely ligated loops in nonimmune rabbits. after 90 min, tissues processed for ultrastructural as well as light microscopy showed that the bacilli were phagocytosed by m cells over lymphoid follicles of peyer's patches and carried in vacuoles into the epithelium. nonpathogenic as well as pathogenic strains were readily taken up regardless of the presence of the 140-megadal ... | 1989 | 2645214 |
| association of ki-ras with amplified dna sequences, detected in human ovarian carcinomas by a modified in-gel renaturation assay. | a modified in-gel dna renaturation technique, which detects dna sequences amplified greater than 7-fold in human dna, was used to analyze gene amplification in surgical specimens of primary and metastatic ovarian carcinomas. amplified dna sequences were detected in two of eight tumors. hybridization of these samples with different oncogene probes revealed that both tumors contained an amplified ki-ras gene, which in one case was coamplified with c-myc. in one of the tumors, ki-ras was found to b ... | 1989 | 2647292 |
| association of ki-ras with amplified dna sequences, detected in human ovarian carcinomas by a modified in-gel renaturation assay. | a modified in-gel dna renaturation technique, which detects dna sequences amplified greater than 7-fold in human dna, was used to analyze gene amplification in surgical specimens of primary and metastatic ovarian carcinomas. amplified dna sequences were detected in two of eight tumors. hybridization of these samples with different oncogene probes revealed that both tumors contained an amplified ki-ras gene, which in one case was coamplified with c-myc. in one of the tumors, ki-ras was found to b ... | 1989 | 2647292 |
| identification of cell types containing s-100b protein-like immunoreactivity in the islets of langerhans of the guinea pig pancreas with light and electron microscopy. | cell types containing s-100b protein-like immunoreactivity in the islets of langerhans of the guinea pig were studied by light- and electron-microscopic immunocytochemistry using antisera to s-100b protein, insulin, glicentin, somatostatin, and pancreatic polypeptide. two types of s-100b-immunoreactive cells were identified. the first type was stellate and characterized by thin cytoplasmic processes sheathing endocrine-type cells, especially pancreatic a-cells. it was located predominantly in th ... | 1989 | 2647297 |
| identification of cell types containing s-100b protein-like immunoreactivity in the islets of langerhans of the guinea pig pancreas with light and electron microscopy. | cell types containing s-100b protein-like immunoreactivity in the islets of langerhans of the guinea pig were studied by light- and electron-microscopic immunocytochemistry using antisera to s-100b protein, insulin, glicentin, somatostatin, and pancreatic polypeptide. two types of s-100b-immunoreactive cells were identified. the first type was stellate and characterized by thin cytoplasmic processes sheathing endocrine-type cells, especially pancreatic a-cells. it was located predominantly in th ... | 1989 | 2647297 |
| heterotopic heart transplantation: a reliable option for a select group of high-risk patients. | from july 1982 through february 1988, 229 patients underwent heart transplantations at the texas heart institute, houston, 11 of whom had heterotopic transplantations. indications for the heterotopic procedure included pulmonary hypertension (eight patients) and marked body-weight mismatch (greater than or equal to 20%) between the recipient and donor (three patients). the 1-year actuarial survival rate for the heterotopic group is 80.4% compared with 77.9% for the orthotopic group. despite simi ... | 1989 | 2647930 |
| delivered volume during high-frequency ventilation. | 1989 | 2648741 | |
| emergence of highly trimethoprim-sulfamethoxazole-resistant shigella in a native american population: an epidemiologic study. | resistance to trimethoprim-sulfamethoxazole (tmp-smx) emerged among shigella isolates from the navajo reservation in the southwestern united states in 1985, years after this antimicrobial agent came into common use. in the study area, tmp-smx resistance increased dramatically from 3 per cent in 1983 to 21 per cent in 1985. resistance was polyclonal and occurred in both s. sonnei and s. flexneri. no single plasmid was common to all resistant strains. however, all 28 tmp-smx resistant isolates exa ... | 1989 | 2650535 |
| identification of an escherichia coli gene homologous to virr, a regulator of shigella virulence. | virulence in shigella spp., as well as in strains of enteroinvasive escherichia coli, is regulated by growth temperature. previously, virr had been identified as the gene controlling the temperature-regulated expression of shigella virulence. since shigella spp. and e. coli are also known to share greater than 90% dna sequence homology, we sought to determine if nonpathogenic e. coli k-12 c600 contains a gene homologous to the shigella flexneri 2a gene virr. through the use of transduction and m ... | 1989 | 2651420 |
| the human gastric bactericidal barrier: mechanisms of action, relative antibacterial activity, and dietary influences. | 1989 | 2651535 | |
| [resistance to infection. physiology and pathology of the immune system]. | the contribution of observations in congenital deficiency disorders to our understanding of normal mechanisms can hardly be overestimated, as may in particular be seen in the complex field of mechanisms aiming at maintaining the individual integrity. after a brief summary of the natural lines of defense we demonstrate a few cases with typical deficiencies, i.e. of the integuments (ciliary dyskinesia syndrome), of the phagocytes (chronic granulomatous disease = cgd), of specific immune reactions ... | 1989 | 2652037 |
| tropical infections after renal transplantation. | 1989 | 2652678 | |
| androgen-regulated gene expression. | while a great deal of knowledge on the mechanisms of steroid hormone regulated gene expression now exists, specific information relating to androgens is lacking. a number of experimental systems have been developed and show promise as models for molecular studies of androgen regulation. further development of these models must address the issue of whether or not the androgen receptor behaves similarly to other steroid receptors. this will require progress in the purification of the receptor itse ... | 1989 | 2653194 |