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myotropic activity and immuno-localization of selected neuropeptides of the burying beetle nicrophorus vespilloides (coleoptera: silphidae).burying beetles (nicrophorus sp.) are necrophagous insects with developed parental care. genome of nicrophorus vespilloides has been recently sequenced, which makes them interesting model organism in behavioural ecology. however, we know very little about their physiology, including the functioning of their neuro-endocrine system. in this study, one of the physiological activities of proctolin, myosuppressin (nicve-ms), myoinhibitory peptide (trica-mip-5) and the short neuropeptide f (nicve-snpf ...201829333681
possible protective effect of the algae spirulina against nephrotoxicity induced by cyclosporine a and/or gamma radiation in rats.the present study was conducted to evaluate the possible protective role of the algae spirulina (sp) against nephrotoxicity and oxidative stress which are the main secondary effects induced by the immunosuppressant drug csa and/or ionizing radiation. in this study, male rats were given sp (1 g/kg) either for 15 days before irradiation (6.5 gy) or 5 days before and 10 days concomitant with csa (25 mg/kg). markers used to assess renal injury included serum creatinine, urea, glucose, albumin, prote ...201829333572
a new species of cretalamna sensu stricto (lamniformes, otodontidae) from the late cretaceous (santonian-campanian) of alabama, usa.decades of collecting from exposures of the upper cretaceous tombigbee sand member of the eutaw formation and mooreville chalk in alabama, usa has produced large numbers of isolated cretalamna (sensu stricto) teeth. many of these teeth had formerly been assigned to the extinct late cretaceous shark cretalamna appendiculata (agassiz, 1843), a taxon that is now considered largely restricted to the turonian of europe. recent studies have shed light on the diversity of late cretaceous cretalamna (s. ...201829333348
ontogeny reversal and phylogenetic analysis of turritopsis sp.5 (cnidaria, hydrozoa, oceaniidae), a possible new species endemic to xiamen, china.ontogeny reversal, as seen in some cnidarians, is an unprecedented phenomenon in the animal kingdom involving reversal of the ordinary life cycle. three species of turritopsis have been shown to be capable of inverted metamorphosis, a process in which the pelagic medusa transforms back into a juvenile benthic polyp stage when faced with adverse conditions. turritopsis sp.5 is a species of turritopsis collected from xiamen, china which presents a similar ability, being able to reverse its life cy ...201829333345
exercise on balance and function for knee osteoarthritis: a randomized controlled trial.to assess balance and function of symptomatic and asymptomatic subjects with knee osteoarthritis (oa) and investigate the influence of physical exercise.201829332761
ischemic compression and kinesiotherapy on chronic myofascial pain in breast cancer survivors.assess the effects of ischemic compression and kinesiotherapy on the rehabilitation of breast cancer survivors with chronic myofascial pain.201829332760
effects of spinal manipulation and myofascial techniques on heart rate variability: a systematic review.the analysis of heart rate variability is important to the investigation of stimuli from the autonomic nervous system. osteopathy is a form of treatment that can influence this system in healthy individuals as well as those with a disorder or disease.201829332747
beyond the "lock and key" paradigm: targeting lipid rafts to induce the selective apoptosis of cancer cells.for more than 40 years, the fluid mosaic model of cellular membranes have supported our vision of an inert lipid bilayer containing membrane protein receptors that are randomly hit by extracellular molecules to trigger intracellular signaling events. however, the notion that compartmentalized cholesterol- and sphingomyelin-rich membrane microdomains (known as lipid rafts) spatially arrange receptors and effectors to promote kinetically favorable interactions necessary for the signal transduction ...201829332565
similarity search combined with docking and molecular dynamics for novel hache inhibitor scaffolds.the main purpose of this study was to address the performance of virtual screening methods based on ligands and the protein structure of acetylcholinesterase (ache) in order to retrieve novel human ache (hache) inhibitors. in addition, a protocol was developed to identify novel hit compounds and propose new promising ache inhibitors from the zinc database with 10 million commercially available compounds. in this sense, 3d similarity searches using rapid overlay of chemical structures and similar ...201829332299
photodynamic antimicrobial chemotherapy (pact) using toluidine blue inhibits both growth and biofilm formation by candida krusei.among non-albicans candida species, the opportunistic pathogen candida krusei emerges because of the high mortality related to infections produced by this yeast. the candida krusei is an opportunistic pathogen presenting an intrinsic resistance to fluconazol. in spite of the reduced number of infections produced by c. krusei, its occurrence is increasing in some groups of patients submitted to the use of fluconazol for prophylaxis. photodynamic antimicrobial chemotherapy (pact) is a potential an ...201829332258
kynurenic acid and its derivatives are able to modulate the adhesion and locomotion of brain endothelial cells.the neuroprotective actions of kynurenic acid (kyna) and its derivatives in several neurodegenerative disorders [characterized by damage to the cerebral endothelium and to the blood-brain barrier (bbb)] are well established. cell-extracellular matrix (ecm) adhesion is supposedly involved in recovery of impaired cerebral endothelium integrity (endothelial repair). the present work aimed to investigate the effects of kyna and its synthetic derivatives on cellular behaviour (e.g. adhesion and locom ...201829332257
heparin-coated grafts reduce mortality in pediatric patients receiving systemic-to-pulmonary shunts.we aimed to evaluate the outcomes of systemic-to-pulmonary (sp) shunt procedures utilizing heparin-coated (hc) polytetrafluoroethylene (ptfe) vascular grafts compared to uncoated (non-hc) grafts, in order to observe any benefits in pediatric patients. our institution switched from using non-hc grafts to hc grafts in march 2011. we conducted a retrospective review of consecutive pediatric patients receiving sp shunts from may 2008 to december 2015. perioperative variables including baseline chara ...201829332215
prevalence of the pfdhfr and pfdhps mutations among asymptomatic pregnant women in southeast nigeria.sulfadoxine-pyrimethamine (sp) is the recommended drug for intermittent preventive treatment of malaria in pregnancy in most of sub-saharan africa. resistance to sp is related to mutations in the dhfr and dhps gene of plasmodium falciparum. this study determined the prevalence of pfdhfr and pfdhps polymorphisms found in asymptomatic pregnant women attending antenatal care in calabar, nigeria. from october 2013 to november 2014, asymptomatic pregnant women attending antenatal care clinics were en ...201829332155
purification and characterization of a novel organic solvent-tolerant and cold-adapted lipase from psychrobacter sp. zy124.by screening 25 different psychrophilic strains isolated from the arctic habitat, we isolated a strain capable of producing lipase. we identified this strain as psychrobacter sp. zy124 based on the amplified 16s rdna sequence. the lipase, named as lipase zc12, produced from the supernatant of psychrobacter sp. zy124 cultured at 15 °c was purified to homogeneity by ammonium sulfate precipitation followed by phenyl sepharose ff gel hydrophobic chromatography. based on the obtained amino acid seque ...201829332142
cultivable fungi present in antarctic soils: taxonomy, phylogeny, diversity, and bioprospecting of antiparasitic and herbicidal metabolites.molecular biology techniques were used to identify 218 fungi from soil samples collected from four islands of antarctica. these consisted of 22 taxa of 15 different genera belonging to the zygomycota, ascomycota, and basidiomycota. mortierella, antarctomyces, pseudogymnoascus, and penicillium were the most frequently isolated genera and penicillium tardochrysogenum, penicillium verrucosus, goffeauzyma gilvescens, and mortierella sp. 2 the most abundant taxa. all fungal isolates were cultivated u ...201829332141
treatment of allergic rhinitis using mobile technology with real world data: the mask observational pilot study.large observational implementation studies are needed to triangulate the findings from randomized control trials (rcts) as they reflect "real world" everyday practice. in a pilot study, we attempted to provide additional and complementary insights on the real life treatment of allergic rhinitis using mobile technology.201829336067
effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia.menopausal women are at high risk of developing heart disease. however, physical exercise practice can reverse this scenario. we evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for ldl receptor with estrogen deprivation by ovariectomy. animals were divided into six groups (n = 5): sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariecto ...201829335884
hydrogen metabolic patterns driven by clostridium-streptococcus community shifts in a continuous stirred tank reactor.the hydrogen (h2) production efficiency in dark fermentation systems is strongly dependent on the occurrence of metabolic pathways derived from the selection of microbial species that either consume molecular h2 or outcompete hydrogenogenic bacteria for the organic substrate. in this study, the effect of organic loading rate (olr) on the h2 production performance, the metabolic pathways, and the microbial community composition in a continuous system was evaluated. two bacterial genera, clostridi ...201829335876
a new species of pararrhopalites bonet & tellez (collembola, symphypleona, sminthuridae) from iron caves in brazil.a second species of the genus pararrhopalites is described from caves inserted in iron ore lithology. both species present a particular sensory organ in the interantennal region. the new species, pararrhopalites ubiquum n.sp., has a wider distribution and it is not restricted to a single cave, as it is the case of pararrhopalites sideroicus zeppelini & brito, in fla entomol 97(4):1733-1744, 2014, being found even in the mesovoid shallow substratum. an update to the previously published identific ...201829335870
hydrogel implant is as effective as osteochondral autologous transplantation for treating focal cartilage knee injury in 24 months.the treatment approach for a patient with knee joint focal cartilage lesion is a difficult decision. to date, there has been no randomized clinical trial involving hydrogel (cartiva™). this study evaluated and compared the results of a hydrogel implant (cartiva™) with autologous osteochondral transplantation (aot) for treating knee joint focal cartilage lesions.201829335748
association of cast2, hsp90aa1, dnaja1 and hspb1 genes with meat tenderness in nellore cattle.the objective of this study was to evaluate the association of expression of capn1, capn2, cast, hsp90aa1, dnaja1 and hspb1 genes with meat tenderness in nellore cattle. three experimental groups were selected by shear force (sf): moderately tender (sf=34.3±5.8n), moderately tough (sf=56.8±7.8n), and very tough meat (sf=80.4±15n). gene expression was evaluated by real-time pcr. expression of the capn1, capn2, cast and cast1 genes did not differ between groups. expression of the cast2 was up-regu ...201829331838
characterization of sp3 bond content of carbon films deposited by high power gas injection magnetron sputtering method by uv and vis raman spectroscopy.this paper presents the results of investigations of carbon films deposited by a modified version of the magnetron sputtering method - hipgims (high power gas injection magnetron sputtering). in this experiment, the magnetron system with inversely polarized electrodes (sputtered cathode at ground potential and positively biased, spatially separated anode) was used. this arrangement allowed us to conduct the experiment using voltages ranging from 1 to 2kv and a power supply system equipped with 2 ...201829331814
alcohol-induced risk behaviors among brazilian nightclub patrons: a latent class analysis.the aim of this study is to identify risk behavior profiles associated with alcohol consumption among patrons during or just after departure from nightclubs in são paulo, brazil.201829331772
the effect of different precooling rates and cold storage on milk microbiological quality and composition.the objective of this study was to measure the effect of different milk cooling rates, before entering the bulk tank, on the microbiological load and composition of the milk, as well as on energy usage. three milk precooling treatments were applied before milk entered 3 identical bulk milk tanks: no plate cooler (np), single-stage plate cooler (sp), and double-stage plate cooler (dp). these precooling treatments cooled the milk to 32.0 ± 1.4°c, 17.0 ± 2.8°c, and 6.0 ± 1.1°c, respectively. milk w ...201829331470
disposable inkjet-printed electrochemical platform for detection of clinically relevant her-2 breast cancer biomarker.rapidly fabricated, disposable sensor platforms hold tremendous promise for point-of-care detection. here, we present an inexpensive (< $0.25) fully inkjet printed electrochemical sensor with integrated counter, reference, and working electrodes that is easily scalable for commercial fabrication. the electrochemical sensor platform featured an inkjet printed gold working 8-electrode array (wea) and counter electrode (ce), along with an inkjet -printed silver electrode that was chlorinated with b ...201829331430
decreased health-related quality of life in children and adolescents with autoimmune hepatitis.the objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis.201829331407
interplay of spkg kinase and the slr0151 protein in the phosphorylation of ferredoxin 5 in synechocystis sp. strain pcc 6803.in synechocystis 6803, the ferredoxin 5 (fd5) phosphoprotein and the s/t protein kinase spkg are encoded by the slr0148 and slr0152 genes respectively, which belong to the slr0144-slr0152 cluster. using a targeted proteomic approach, we showed that spkg is responsible for the phosphorylation of fd5 on residues t18 and t72. sequence alignments and fd5 structure modelling suggest that these phosphorylation events modulate protein-protein interaction. further, fd5 phosphorylation is affected by the ...201829331018
biochemical characterization of recombinant thermostable cohnella sp. a01 β-glucanasetypically, non-cellulytic glucanase, including fungi and yeast cell wall hydrolyzing enzymes, are release by some symbiotic fungi and plants during the mycoparasitic fungi attack on plants. these enzymes are known as the defense mechanisms of plants. this study intends to investigate the biochemical properties of β-1,6-glucanase (bg16m) from native thermophilic bacteria, cohnella a01.201829331014
henoch-schönlein purpura nephritis: initial risk factors and outcomes in a latin american tertiary center.the objective of this study was to evaluate prevalence, initial risk factors, and outcomes in henoch-schönlein purpura nephritis (hspn) patients in latin america. two hundred ninety-six patients (validated eular/printo/pres hsp criteria) were assessed by demographic data, clinical/laboratorial involvements, and treatments in the first 3 months after diagnosis. they were followed-up in a latin american tertiary center and were divided in two groups: with and without nephritis. persistent non-neph ...201829330742
glycogen production in marine cyanobacterial strain synechococcus sp. nkbg 15041c.an important feature offered by marine cyanobacterial strains over freshwater strains is the capacity to grow in seawater, replacing the need for often-limited freshwater. however, there are only limited numbers of marine cyanobacteria that are available for genetic manipulation and bioprocess applications. the marine unicellular cyanobacteria synechococcus sp. strain nkbg 15041c (nkbg15041c) has been extensively studied. recombinant dna technologies are available for this strain, and its genomi ...201829330710
volatile compounds from beneficial or pathogenic bacteria differentially regulate root exudation, transcription of iron transporters, and defense signaling pathways in sorghum bicolor.our results show that sorghum bicolor is able to recognize bacteria through its volatile compounds and differentially respond to beneficial or pathogens via eliciting nutritional or defense adaptive traits. plants establish beneficial, harmful, or neutral relationships with bacteria. plant growth promoting rhizobacteria (pgpr) emit volatile compounds (vcs), which may act as molecular cues influencing plant development, nutrition, and/or defense. in this study, we compared the effects of vcs prod ...201829330694
the effectiveness of problem-solving therapy for primary care patients' depressive and/or anxiety disorders: a systematic review and meta-analysis.there is increasing demand for managing depressive and/or anxiety disorders among primary care patients. problem-solving therapy (pst) is a brief evidence- and strength-based psychotherapy that has received increasing support for its effectiveness in managing depression and anxiety among primary care patients.201829330248
clinical challenges of antimicrobial photodynamic therapy for bovine mastitis. 201829330053
effects of acupuncture on the heart rate variability, cortisol levels and behavioural response induced by thunder sound in beagles.sound stimuli such as fireworks, firearms, and claps of thunder have been used as a stress reactivity model for dogs. acupuncture has been widely used to treat and prevent physiological and behavioural disorders induced by stress. our study aims to evaluate the effects of acupuncture on cardiac autonomic modulation (heart rate variability - hrv), behavioural (reactivity) and endocrine (cortisol levels) responses in dogs exposed to sounds of thunder. twenty-four laboratory beagles (12 males and 1 ...201829330044
quercetin decrease somatic cells count in mastitis of dairy cows.quercetin is a dietary flavonoid which has an effect on inflammation, angiogenesis and vascular inflammation. in several other flavonoids (e.g. kaempferol, astragalin, alpinetin, baicalein, indirubin), anti-inflammatory mechanism was proven by using mice mastitis model. the aim of the current study was pilot analysis of quercetin tolerability and its impact on somatic cells count (scc) after multiple intramammary treatment on dairy cows with clinical mastitis. based on scc and clinical investiga ...201829331686
acinetobacter baumannii st317 can be identified with martins' trilocus sequence-based multiplex-pcr. 201829331669
normative distribution of substance p and its tachykinin neurokinin-1 receptor in the medullary serotonergic network of the human infant during postnatal development.substance p (sp) and its tachykinin nk1 receptor (nk1r) function within key medullary nuclei to regulate cardiorespiratory and autonomic control. we examined the normative distribution of sp and nk1r in the serotonergic (5-hydroxytryptamine, [5-ht]) network of the human infant medulla during postnatal development, to provide a baseline to facilitate future analysis of the sp/nk1r system and its interaction with 5-ht within pediatric brainstem disorders in early life. [125i] labelled bolton hunte ...201829331576
estimates of repeatability and correlations of hemoparasites infection levels for cattle reared in endemic areas for rhipicephalus microplus.rhipicephalus microplus is a vector of cattle tick fever, a disease caused by the protozoans babesia bovisand b. bigemina, and also anaplasmosis, produced by the rickettsiales anaplasma marginale. these tick-borne pathogens cause considerable losses to brazilian livestock breeders and represent an obstacle to the expanded use of taurine breeds due to their higher sensitivity to ticks and hemoparasites compared to zebu breeds. differences in the susceptibility to hemoparasites were also verified ...201829329629
determination and validation of discriminating concentration of ivermectin against rhipicephalus microplus.rhipicephalus microplus, the major cattle tick species of india is prevalent all over the country and causes huge economic loss directly or indirectly to the dairy industries. chemical acaricides are playing an important role in managing tick infestations on livestock for many years and consequently, resistance to commonly used organophosphate (op) and synthetic pyrethroid (sp) compounds has been reported. subsequently, ivermectin (ivm) has been emerged as an alternative to manage op and sp resi ...201829329620
comparative analysis of uranium bioassociation with halophilic bacteria and archaea.rock salt represents a potential host rock formation for the final disposal of radioactive waste. the interactions between indigenous microorganisms and radionuclides, e.g. uranium, need to be investigated to better predict the influence of microorganisms on the safety assessment of the repository. hence, the association process of uranium with two microorganisms isolated from rock salt was comparatively studied. brachybacterium sp. g1, which was isolated from the german salt dome gorleben, and ...201829329319
simultaneous accelerated solvent extraction and hydrolysis of 11-nor-δ9-tetrahydrocannabinol-9-carboxylic acid glucuronide in meconium samples for gas chromatography-mass spectrometry analysis.cannabis misuse during pregnancy is associated with severe impacts on the mother and baby health, such as newborn low birth weight, growth restriction, pre-term birth, neurobehavioral and developmental deficits. in most of the cases, drug abuse is omitted or denied by the mothers. thus, toxicological analyzes using maternal-fetal matrices takes place as a suitable tool to assess drug use. herein, meconium was the chosen matrix to evaluate cannabis exposure through identification and quantificati ...201829329090
directing group participated benzylic c(sp3)-h/c(sp2)-h cross-dehydrogenative coupling (cdc): synthesis of azapolycycles.an efficient method to construct azapolycycles via directing group participated benzylic c(sp3)-h/c(sp2)-h cross-dehydrogenative coupling reactions is described. the reaction proceeded through a palladium catalyzed c(sp3)-h activation followed by coupling with a c(sp2)-h bond of quinoline to afford the azapolycyclic compounds. the reaction works with a broad substrate scope affording the products in moderate to good yields with excellent diastereoselectivities. control experiments further suppor ...201829328666
thalamic atrophy in ms: an mri marker of neurodegeneration throughout disease.thalamic volume is a candidate mri-based marker associated with neurodegeneration to hasten development of neuroprotective treatments. our objective is to describe the longitudinal evolution of thalamic atrophy in ms and normal aging, and to estimate sample sizes for study design.201829328531
surface modification using the biomimetic method in alumina-zirconia porous ceramics obtained by the replica method.the modification of biomaterials approved by the food and drug administration could be an alternative to reduce the period of use in humans. porous bioceramics are widely used as support structures for bone formation and repair. this composite has essential characteristics for an implant, including good mechanical properties, high chemical stability, biocompatibility and adequate aesthetic appearance. here, three-dimensional porous scaffolds of al2 o3 containing 5% by volume of zro2 were produce ...201829328519
oxidative radical divergent si-incorporation: facile access to si-containing heterocycles.a copper-catalyzed oxidative radical strategy to avoid the use of the highly expensive noble metal/ligand catalytic systems is described, which allows selective activation of dual chemical bonds around the si-atom center relying on the nature of alkylsilanes. while for tertiary silanes selective functionalization of si-h/silyl c(sp3)-h bonds in intermolecular oxidative annulation cascades with n-(2-(ethynyl)aryl)acrylamides toward silino[3,4-c]quinolin-5(3h)-ones, when using secondary silanes an ...201829328345
localized excitation of polarized light emission by cathodoluminescence spectroscopy.surface plasmons (sps), the resonance of free electrons on the metal-air interface, may strongly interact with light and generate some extraordinary optical effects. instead of using conventional planar light excitation, here we excite sps with a focused electron beam on metallic nanostructures with different geometrical symmetries. with the help of a polarizer and filter in the detection system, we obtain cathodoluminescence (cl) images with different polarizations at certain wavelengths. the m ...201829328221
cyanobacterial photosynthesis under sulfidic conditions: insights from the isolate leptolyngbya sp. strain hensonii.we report the isolation of a pinnacle-forming cyanobacterium isolated from a microbial mat covering the sediment surface at little salt spring-a flooded sinkhole in florida with a perennially microoxic and sulfidic water column. the draft genome of the isolate encodes all of the enzymatic machinery necessary for both oxygenic and anoxygenic photosynthesis, as well as genes for methylating hopanoids at the c-2 position. the physiological response of the isolate to h2s is complex: (i) no induction ...201829328062
afrina sporoboliae sp. n. (nematoda: anguinidae) associated with sporobolus cryptandrus (torr.) a. gray from idaho, usa; phylogenetic relationships and population structure.the dropseed gall-forming nematode, afrina sporoboliae sp. n., is described from seed galls of sporobolus cryptandrus (poaceae: chloridoideae: sporobolinae) collected in idaho, usa. this is the third report of an afrina species in north america and the first report of this genus in a natural plant population on this continent. morphological, morphometric, and molecular analyses placed this nematode in genus afrina and demonstrated that it differs from af. hyparrheniae and af. spermophaga by havi ...201829327647
gamma-aminobutyric acid enriched rice bran diet attenuates insulin resistance and balances energy expenditure via modification of gut microbiota and short-chain fatty acids.in this study, gamma-aminobutyric acid (gaba) enriched rice bran (erb) was supplemented to obese rats to investigate the attenuation of metabolic syndromes induced by high-fat diet. erb-containing diet stimulated butyrate and propionate production by promoting anaerostipes, anaerostipes sp., and associated synthesizing enzymes. this altered short-chain fatty acid (scfa) distribution further enhanced circulatory levels of leptin and glucagon-like peptide-1, controlling food intake by downregulati ...201829327584
relative stability of ploidy in a marine synechococcus across various growth conditions.marine picocyanobacteria of the genus synechococcus are ubiquitous phototrophs in oceanic systems. consistent with these organisms occupying vast tracts of the nutrient impoverished ocean, most marine synechococcus so far studied are monoploid i.e. contain a single chromosome copy. the exception is the oligoploid strain synechococcus sp. wh7803, which on average possesses around 4 chromosome copies. here, we set out to understand the role of resource availability (through nutrient deplete growth ...201829327508
nitrogen sources affect productivity, desiccation tolerance, and storage stability of beauveria bassiana blastospores.nitrogen is a critical element in industrial fermentation media. this study investigated the influence of various nitrogen sources on blastospore production, desiccation tolerance, and storage stability using two strains of the cosmopolitan insect pathogenic fungus beauveria bassiana.201829327477
tuning the activity of carbon for electrocatalytic hydrogen evolution via an iridium-cobalt alloy core encapsulated in nitrogen-doped carbon cages.graphene, a 2d material consisting of a single layer of sp2 -hybridized carbon, exhibits inert activity as an electrocatalyst, while the incorporation of heteroatoms (such as n) into the framework can tune its electronic properties. because of the different electronegativity between n and c atoms, electrons will transfer from c to n in n-doped graphene nanosheets, changing inert c atoms adjacent to the n-dopants into active sites. notwithstanding the achieved progress, its intrinsic activity in ...201829327475
aboveground herbivory-induced jasmonates disproportionately reduce plant reproductive potential by facilitating root nematode infestation.different plant-feeders, including insects and parasitic nematodes, can influence each other by triggering systemic changes in their shared host plants. in most cases however, the underlying mechanisms are unclear, and the consequences for plant fitness are not well understood. we studied the interaction between leaf feeding manduca sexta caterpillars and root parasitic nematodes in nicotiana attenuata. simulated manduca sexta attack increased the abundance of root parasitic nematodes in the fie ...201829327360
inclusion complex and nanoclusters of cyclodextrin to increase the solubility and efficacy of albendazole.albendazole (abz), a benzimidazole widely used to control gastrointestinal parasites, is poorly soluble in water, resulting in variable and incomplete bioavailability. this has favored the appearance abz-resistant nematodes and, consequently, an increase in its clinical ineffectiveness. among the pharmaceutical techniques developed to increase drug efficacy, cyclodextrins (cds) and other polymers have been extensively used with water-insoluble pharmaceutical drugs to increase their solubility an ...201829327323
phylogenetic analysis and biological evaluation of marine endophytic fungi derived from red sea sponge hyrtios erectus.forty-four endophytic fungal isolates obtained from marine sponge, hyrtios erectus, were evaluated and screened for their hydrolase activities. most of the isolates were found to be prolific producers of hydrolytic enzymes. only 11 isolates exhibited maximum cellular contents of lipids, rhamnolipids, and protein in the fungal isolates under the isolation numbers merva5, merva22, merva25, merva29, merva32, merva34, merv36, merva39, merva42, merva43, and merva44. these isolate extracts exhibit the ...201829327320
isolated avulsion fracture of the first metatarsal base at the peroneus longus tendon attachment: a case report.avulsion fractures of the first metatarsal (mt1) base at the peroneus longus (pl) tendon attachment are rare and may be undiagnosed during an emergency visit. if the injury is not treated properly, chronic pain or persistent impairment for inversion and plantar-flexion of the first ray may occur. this case report presents a 30-year-old woman who presented 10 weeks post trauma to a foot and ankle surgeon due to a swollen right midfoot with diffuse tenderness over the medial lisfranc joint. furthe ...201829327128
evaluation of committed and primitive cord blood progenitors after expansion on adipose stromal cells.umbilical cord blood mononuclear fraction is a valuable source of hematopoietic stem and progenitor cells (cb hspcs). the rarity of this population is a serious limitation of its application in cell therapy. ex vivo expansion enables to significantly amplify the number of hematopoietic precursors of different commitment. here, we expand cb mncs in co-culture with human adipose tissue-derived stromal cells (ascs) to enrich hspcs and describe phenotypic features of newly formed hematopoietic popul ...201829327082
a cu(ii) metal-organic framework with significant h2 and co2 storage capacity and heterogeneous catalysis for the aerobic oxidative amination of c(sp3)-h bonds and biginelli reactions.a cu(ii) metal-organic framework, {[cu2(l)(h2o)2]·(5dmf)(4h2o)}n (1), has been synthesized using an angular tetracarboxylic acid ligand (h4l) incorporating both trifluoromethyl (-cf3) and amine (-nh2) groups. notably, the framework possesses high water and thermal stability. at atmospheric pressure, the activated framework 1' exhibits substantially high amounts of co2 (35.5 and 20.8 wt% at 273 and 298 k respectively) and h2 (1.72 wt% at 77 k) adsorption. also, 1' exhibits excellent catalytic act ...201829326992
transcriptome datasets of macrophages infected with different strains of leptospira spp.the datasets reported herein provide information about microarray experiment of macrophage cell line j774a.1 infected with three different strains of leptospira spp. transcriptomic profiles were generated using affymetrix® mouse gene 2.1 st array strip. data was normalized and statically process, p-value < 0.01, fdr < 0.05 and log2 fold change (± 2). the microarray raw data are available in gene expression omnibus (geo) under accession number gse105141.201829326966
sleep findings in brazilian children with congenital zika syndrome.zika virus infection during pregnancy may result in congenital zika syndrome (czs), whose characteristics are being described.201829325155
subject-specific pulse wave propagation modeling: towards enhancement of cardiovascular assessment methods.cardiovascular diseases are the leading cause of death worldwide. pulse wave analysis (pwa) technique, which reconstructs and analyses aortic pressure waveform based on non-invasive peripheral pressure recording, became an important bioassay for cardiovascular assessment in a general population. the aim of our study was to establish a pulse wave propagation modeling framework capable of matching clinical pwa data from healthy individuals on a per-subject basis. radial pressure profiles from 20 h ...201829324835
course of sp-d, ykl-40, ccl18 and ca 15-3 in adult patients hospitalised with community-acquired pneumonia and their association with disease severity and aetiology: a post-hoc analysis.sp-d, ykl-40, ccl18 and ca 15-3 are pulmonary markers that have been extensively investigated in different chronic pulmonary diseases. however, in acute pulmonary diseases, such as community-acquired pneumonia (cap), little is known about the course of these markers and their relationship with the aetiological agent. the aim of this study was to investigate the course of these four markers in cap and to study influence of disease severity, aetiology and antibiotic use prior to admission on their ...201829324810
genome-wide identification, characterization and expression profile analysis of expansins gene family in sugarcane (saccharum spp.).expansins refer to a family of closely related non-enzymatic proteins found in the plant cell wall that are involved in the cell wall loosening. in addition, expansins appear to be involved in different physiological and environmental responses in plants such as leaf and stem initiation and growth, stomata opening and closing, reproduction, ripening and stress tolerance. sugarcane (saccharum spp.) is one of the main crops grown worldwide. lignocellulosic biomass from sugarcane is one of the most ...201829324804
barriers of attendance to dog rabies static point vaccination clinics in blantyre, malawi.rabies is a devastating yet preventable disease that causes around 59,000 human deaths annually. almost all human rabies cases are caused by bites from rabies-infected dogs. a large proportion of these cases occur in sub saharan africa (ssa). annual vaccination of at least 70% of the dog population is recommended by the world health organisation in order to eliminate rabies. however, achieving such high vaccination coverage has proven challenging, especially in low resource settings. despite bei ...201829324737
physiological and comparative genomic analysis of arthrobacter sp. srs-w-1-2016 provides insights on niche adaptation for survival in uraniferous soils.arthrobacter sp. strain srs-w-1-2016 was isolated on high concentrations of uranium (u) from the savannah river site (srs) that remains co-contaminated by radionuclides, heavy metals, and organics. srs is located on the northeast bank of the savannah river (south carolina, usa), which is a u.s. department of energy (doe) managed ecosystem left historically contaminated from decades of nuclear weapons production activities. predominant contaminants within the impacted srs environment include u an ...201829324691
traditional vs. suspended pushup muscle activation in athletes and sedentary females.many strength training (st) programs incorporate pushup exercises, which primarily activate upper body muscles. past data supports the fact that shoulder girdle muscles [i.e., triceps (t) and anterior deltoids (ad)] exhibit greater electromyography (emg) activity when a pushup is performed on an unstable [i.e., suspended (sp)] vs. stable [i.e., traditional (td)] surface (andrade, 2011). sixty-nine healthy female volunteers [soccer players (so), n=24; gymnasts (gy), n=21; sedentary (se), n=24) pe ...201829324579
cardiopulmonary effects induced by occupational exposure to titanium dioxide nanoparticles.although some toxicological studies have reported that exposure to titanium dioxide nanoparticles (nano-tio2) may elicit adverse cardiopulmonary effects, related data collected from human are currently limited. the purpose of this study is to explore cardiopulmonary effects among workers who were exposed to nano-tio2 and to identify biomarkers associated with exposure. a cross-sectional study was conducted in a nano-tio2 manufacturing plant in eastern china. exposure assessment and characterizat ...201829324056
esophageal manometry and regional transpulmonary pressure in lung injury.esophageal manometry is the clinically available method to estimate pleural pressure, thus enabling calculation of the transpulmonary pressure (pl). however, many concerns make uncertain in which lung region esophageal manometry reflects local pl.201829323931
the acetabular and spino-pelvic morphologies are different in subjects with symptomatic cam femoro-acetabular impingement.acetabular and spino-pelvic (sp) morphological parameters are important determinants of hip joint dynamics. this prospective study aimed to determine whether acetabular and sp morphological differences exist between hips with and without cam morphology and between symptomatic and asymptomatic hips with cam morphology. a cohort of 67 patients/hips was studied. hips were either asymptomatic with no cam (controls, n = 18), symptomatic with cam (n = 26) or asymptomatic with cam (n = 23). ct-based qu ...201829323746
identification of a novel botulinum neurotoxin gene cluster in enterococcus.the deadly neurotoxins of clostridium botulinum (bonts) comprise eight serotypes (a-g; x). the neurotoxin gene cluster encoding bont and its accessory proteins includes an operon containing an ntnh gene upstream of the bont gene. another operon contains either ha (haemagglutinin) or orfx genes (of unknown function). here we describe a novel bont gene cluster from enterococcus sp. 3g1_div0629, with a typical ntnh gene and an uncommon orfx arrangement. the neurotoxin (designated putative ebont/j) ...201829323697
negative poisson's ratio and high-mobility transport anisotropy in sic6 siligraphene.the diverse forms of silicon carbides lead to versatile properties, but an auxetic allotrope at zero pressure has never been reported. here, using first-principles calculations we propose a two-dimensional (2d) auxetic silicon carbide material, namely sic6 siligraphene. the plausibility of the sic6 siligraphene is verified by the low formation energy, positive phonon spectrum and high mechanical stability. the unique framework of sp2 carbon and sp3 silicon atoms leads to unusual in-plane negativ ...201829323686
on-demand synthesis of organozinc halides under continuous flow conditions.organozinc reagents are versatile building blocks for introducing c(sp2)-c(sp3) and c(sp3)-c(sp3) bonds into organic structures. however, despite their ample synthetic versatility and broad functional group tolerance, the use of organozinc reagents in the laboratory is limited because of their instability, exothermicity and water sensitivity, as well as their labor-intensive preparation. herein, we describe an on-demand synthesis of these useful reagents under continuous flow conditions, overcom ...201829323664
catheter-associated urinary tract infections in persons with neurogenic bladders.this review is based on the author's donald munro lecture given at the annual conference of the academy of spinal cord injury professionals in new orleans, la. indwelling catheters play an important role in bladder management following sci for many individuals with neurogenic bladders. there is an increased risk of uti compared to other types of bladder management with indwelling urethral catheters but not sp catheters. to minimize the risk of symptomatic uti, the following steps are essential: ...201829323625
high positive end-expiratory pressure renders spontaneous effort non-injurious.in ards, atelectatic 'solid-like' lung tissue impairs transmission of negative 'swings' in pleural pressure (ppl) resulting from diaphragmatic contraction. the localization of more negative ppl proportionally increases dependent lung stretch by drawing gas either from other lung regions, e.g., non-dependent lung (pendelluft) or from the ventilator. lowering of the level of spontaneous effort and/or converting solid-like to fluid-like lung might render spontaneous effort non-injurious.201829323536
chemical profiling of two congeneric sea mat corals along the brazilian coast: adaptive and functional patterns.metabolomic profiles were explored to understand environmental and taxonomic influences on the metabolism of two congeneric zoanthids, palythoa caribaeorum and p. variabilis, collected across distinct geographical ranges. integrated mass spectrometry data suggested the major influence of geographical location on chemical divergence when compared to species differentiation.201829323379
expression of cry2ah1 and two domain ii mutants in transgenic tobacco confers high resistance to susceptible and cry1ac-resistant cotton bollworm.to improve the novel bacillus thuringiensis insecticidal gene cry2ah1 toxicity, two mutants cry2ah1-vp (v354vp) and cry2ah1-sp (v354sp) were performed. swiss-model analysis showed two mutants had a longer loop located between β-4 and β-5 of domain ii, resulting in higher binding affinity with brush border membrane vesicles (bbmv) of helicoverpa armigera comparing with cry2ah1. the cry2ah1, cry2ah1-vp, and cry2ah1-sp were optimized codon usage according to plant codon bias, and named mcry2ah1, mc ...201829323243
gastropod shell size and architecture influence the applicability of methods used to estimate internal volume.obtaining accurate and reproducible estimates of internal shell volume is a vital requirement for studies into the ecology of a range of shell-occupying organisms, including hermit crabs. shell internal volume is usually estimated by filling the shell cavity with water or sand, however, there has been no systematic assessment of the reliability of these methods and moreover no comparison with modern alternatives, e.g., computed tomography (ct). this study undertakes the first assessment of the m ...201829323195
new anti-inflammatory guaianes from the atlantic hydrotherm-derived fungus graphostroma sp. mccc 3a00421.nine new guaianes (graphostromanes a-i, 1-9) were isolated from the deep-sea-derived fungus graphostroma sp. mccc 3a00421, along with four known ones (10-13). the relative configurations were established mainly by detailed analysis of the nmr and hresims data, while the absolute configurations were assigned using the x-ray crystallography and modified mosher's method. all isolates were evaluated for their inhibitory effects against lipopolysaccharide (lps)-induced nitric oxide (no) production in ...201829323171
observation of layered antiferromagnetism in self-assembled parallel nisi nanowire arrays on si(110) by spin-polarized scanning tunneling spectromicroscopy.the layered antiferromagnetism of parallel nanowire (nw) arrays self-assembled on si(110) have been observed at room temperature by direct imaging of both the topographies and magnetic domains using spin-polarized scanning tunneling microscopy/spectroscopy (sp-stm/sts). the topographic stm images reveal that the self-assembled unidirectional and parallel nisi nws grow into the si(110) substrate along the [formula: see text] direction (i.e. the endotaxial growth) and exhibit multiple-layer growth ...201829322945
purification and characterization of a novel high molecular weight alkaline protease produced by an endophytic bacillus halotolerans strain ct2.a protease-producing strain ct2 isolated from tunisian potatoes, exhibiting a potent protease activity (prot ct2), was identified as bacillus halotolerans according to 16s ribosomal dna sequence analysis. maximum prot ct2 production was obtained in medium supplemented with bean seed proteins. proteolytic activity was purified by ammonium sulphate precipitation, sephacryl s-200 gel filtration and sp-sepharose cation-exchange chromatography. optimal enzyme activity was reached at ph 9 and temperat ...201829320724
genetic diversity of cryptosporidium isolates from human populations in an urban area of northern tunisia.cryptosporidium is an enteric parasite infecting a wide range of hosts. it has emerged as an important cause of chronic life-threatening diarrhea in humans worldwide. several subtypes of cryptosporidium sp. have been described to be responsible for several large outbreaks related to water contamination in developed countries. however, there is a lack of information in the genetic diversity of cryptosporidium among human population especially in developing countries. the present study aimed to up ...201829320719
the glutamine synthetase of trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection.trypanosoma cruzi, the etiological agent of chagas disease, consumes glucose and amino acids depending on the environmental availability of each nutrient during its complex life cycle. for example, amino acids are the major energy and carbon sources in the intracellular stages of the t. cruzi parasite, but their consumption produces an accumulation of nh4+ in the environment, which is toxic. these parasites do not have a functional urea cycle to secrete excess nitrogen as low-toxicity waste. glu ...201829320490
bacillibactin and bacillomycin analogues with cytotoxicities against human cancer cell lines from marine bacillus sp. pku-ma00093 and pku-ma00092.nonribosomal peptides from marine bacillus strains have received considerable attention for their complex structures and potent bioactivities. in this study, we carried out pcr-based genome mining for potential nonribosomal peptides producers from our marine bacterial library. twenty-one "positive" strains were screened out from 180 marine bacterial strains, and subsequent small-scale fermentation, hplc and phylogenetic analysis afforded bacillus sp. pku-ma00092 and pku-ma00093 as two candidates ...201829320403
antimicrobial and antioxidant activities of two polyketides from lichen-endophytic fungus preussia sp.two compounds, compounds 1 and 2, were isolated from preussia sp. the molecular structures of both compounds were elucidated by analyzing one-dimensional (1d) and 2d nuclear magnetic resonance data along with high-resolution mass spectrometry data. compound 1 was obtained as novel in structure, and compound 2 was recently reported elsewhere. compound 1 did not show antioxidant and antimicrobial activities and brine shrimp toxicity, while compound 2 showed strong antioxidant activity (dpph reduct ...201829320367
neuromyelitis optica spectrum disorders: spectrum of mr imaging findings and their differential diagnosis.neuromyelitis optica (nmo) is an autoimmune demyelinating disorder for which the aquaporin-4 (aqp4) water channels are the major target antigens. advances in the understanding of nmo have clarified several points of its pathogenesis, clinical manifestations, and imaging patterns. a major advance was the discovery of the aqp4 antibody, which is highly specific for this disorder. descriptions of new clinical and radiologic features in seropositive patients have expanded the spectrum of nmo, and th ...201829320331
atypical sites of deeply infiltrative endometriosis: clinical characteristics and imaging findings.endometriosis is defined as the presence of endometrial tissue that is located outside the uterine cavity and associated with fibrosis and inflammatory reaction. it is a polymorphic and multifocal disease with no known cure or preventive mechanisms. patients may be asymptomatic or may experience chronic pelvic pain, dysmenorrhea, dyspareunia, or infertility. the pelvic cavity is the most common location for endometriotic implants, which usually affect the retrocervical space, ovaries, vagina, re ...201829320327
translabial us and dynamic mr imaging of the pelvic floor: normal anatomy and dysfunction.pelvic floor dysfunction (pfd) is a common condition that typically affects women older than 50 years and decreases the quality of life. weakening of support structures can involve all three pelvic compartments and cause a combination of symptoms, including constipation, urinary and fecal incontinence, obstructed defecation, pelvic pain, perineal bulging, and sexual dysfunction. the causes of pfd are complex and multifactorial; however, vaginal delivery is considered a major predisposing factor. ...201829320316
stereospecific stille cross-couplings using mn(ii)cl2.cross-coupling reactions are a staple in organic synthesis, especially for c-c bond formation with sp- and sp2-carbon electrophiles. in recent years, the range of accessible c-c bonds has been extended to stereogenic centers which expedites access to greater molecular complexity. however, these reactions predominantly depend upon late transition metal (ltm) catalysts whose cost, toxicity, and/or environmental impact have come under increasing scrutiny and governmental regulation. here, we report ...201829320181
crystal structure of an aldehyde oxidase from methylobacillus sp. ky4400.hetero-trimeric aldehyde oxidases of bacterial origin, which use o2 to catalyse the oxidation of various aldehydes but not those of aromatic n-heterocycles, belong to the xanthine oxidase family. in the present study, the crystal structure of a recombinant aldehyde oxidase from methylobacillus sp. ky4400 (mb-aox) was determined at 2.5 å resolution. the structures of its subunits resemble those of the corresponding subunits or domains of other structurally characterised enzymes belonging to the f ...201829319807
characterization of a novel endo-type alginate lyase derived from shewanella sp. yh1.alginate, which is an anionic polysaccharide, is widely distributed in the cell wall of brown algae. alginate and the products of its degradation (oligosaccharides) are used in stabilizers, thickeners, and gelling agents, especially in the food industry. the degradation of alginate generally involves a combination of several alginate lyases (exo-type, endo-type, and oligoalginate lyase). enhancing the efficiency of the production of alginate degradation products may require the identification of ...201829319800
the effect of isabelin, a sesquiterpene lactone from ambrosiaartemisiifolia, on soil microorganisms and human pathogens.ambrosia artemisiifolia l. (common ragweed) is an invasive weed, well-known for the strong allergenic effect of its pollen, as well as for its invasiveness and impact in crop fields (e.g. causing yield losses). this species produces a broad range of sesquiterpenoids. in recent years, new bioactive molecules have been discovered in this plant, e.g. isabelin, a sesquiterpene dilactone. the bioactivity of isabelin has been already demonstrated on allergy-related receptors and its inhibitory effect ...201829319784
granulomatous intersticial nephritis secondary to sarcoidosis.granulomatous interstitial nephritis is a rare condition, in which renal involvement is uncommon. its etiology is variable, and may be medicinal, infectious or inflammatory origin.201829319778
clinical and histological features of patients with membranoproliferative glomerulonephritis classified by immunofluorescence findings.new classification for membranoproliferative glomerulonephritis has been proposed in the literature. the aim of this study was to compare the clinical, biochemical, etiology and renal biopsy findings of these patients grouped by immunofluorescence as proposed by the new classification.201829319772
peritoneal dialysis as the first dialysis treatment option initially unplanned.most patients with stage 5 ckd start rrt of unplanned manner. unplanned dialysis, also known as urgent start, may be defined as hemodialysis (hd) started without permanent vascular access, i.e., using a central venous catheter (cvc), or as peritoneal dialysis (pd) started within seven days after implantation of the catheter, without family training. although few studies have evaluated the pd as an immediate treatment option for patients starting urgent rrt, theirs results suggest that it is a fe ...201829319771
factors associated with hospital mortality in renal transplant patients admitted to the intensive care unit with acute respiratory failure.the lungs are often involved in a variety of complications after kidney transplantation. acute respiratory failure (arf) is one of the most serious manifestations of pulmonary involvement.201829319770
impact of an early physiotherapy program after kidney transplant during hospital stay: a randomized controlled trial.cardiorespiratory and musculoskeletal dysfunctions are common in the postoperative period of kidney transplant patients and are often accompanied by low exercise tolerance.201829319769
the current burden of cytomegalovirus infection in kidney transplant recipients receiving no pharmacological prophylaxis.cytomegalovirus (cmv) infection in kidney transplantation has changed its clinical spectrum, mostly due to the current and more effective immunosuppression. in the absence of preventive strategies it is associated with significant morbi-mortality.201829319768
epic trial: education programme impact on serum phosphorous control in ckd 5d patients on hemodialysis.in stage 5d chronic kidney disease (ckd 5d) patients, the encouragement of treatment adherence by health professionals is a significant clinical challenge.201829319766
isotonic sports drink promotes rehydration and decreases proteinuria following karate training.adequate hydration status in the sport is essential for good health, yet the relationship between hydration, proteinuria and sports is little studied.201829319761
cytomegalovirus infection after transplantation: prevention is still the challenge. 201829319758
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