Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| multiplication of an ancestral gene encoding secreted fungalysin preceded species differentiation in the dermatophytes trichophyton and microsporum. | dermatophytes are human and animal pathogenic fungi which cause cutaneous infections and grow exclusively in the stratum corneum, nails and hair. in a culture medium containing soy proteins as sole nitrogen source a substantial proteolytic activity was secreted by trichophyton rubrum, trichophyton mentagrophytes and microsporum canis. this proteolytic activity was 55-75 % inhibited by o-phenanthroline, attesting that metalloproteases were secreted by all three species. using a consensus probe co ... | 2004 | 14766908 |
| isolation of a promoter region of a secreted metalloprotease gene from microsporum canis. | mep3 of microsporum canis encodes a 43.5 kda extracellular keratinolytic metalloprotease, which is thought to be one of the virulence-related factors in dermatophytosis. in order to analyze the system underlying the regulation of mep3 gene expression, the 5'-upstream region was isolated by inverse pcr. the nucleotide sequence of a dna fragment of about 2.1 kb containing the coding region contains putative transcription factor binding sites and transcriptional initiation points. further analyses ... | 2004 | 14985633 |
| therapeutic options in the treatment of tinea capitis. | tinea capitis is primarily a disease of pre-adolescent children. in north america and the uk, trichophyton tonsurans is responsible for > 90% of cases. microsporum canis is the predominant pathogen in certain parts of europe. the standard of care for the treatment of tinea capitis is oral griseofulvin and so far, it remains the only medication approved by the us fda for this condition. the newer oral antifungal agents, such as terbinafine, itraconazole and fluconazole, appear to be effective, sa ... | 2004 | 14996619 |
| etiology of tinea capitis in athens, greece -- a 6-year (1996-2001) retrospective study. | a total of 577 patients with tinea capitis have been diagnosed at the mycology laboratory of 'a. sygros' hospital of skin and venereal diseases, athens, greece between 1996 and 2001. from these patients, 100 were immigrants from balkan, near east and african countries. the vast majority of the patients (95%) were children, mainly at preschool and school age and only 5% were adults. zoophilic dermatophytes accounted for 86.5% followed by anthropophilic (12.4%) and geophilic (1.2%) dermatophytes. ... | 2004 | 15189185 |
| the epidemiology of microsporum canis infections in rijeka area, croatia. | the aim of the study was to analyze the microsporum canis infections in the rijeka area, croatia, observed between 1990 and 2001. a total of 724 cases of dermatophytosis caused by m. canis were diagnosed in 320 individuals with the tinea capitis and 404 with tinea corporis. the m. canis infections constituted 32.8% of all dermatophytes isolated during the study period. | 2004 | 15189188 |
| kerion celsi in a newborn due to microsporum canis. | the present study deals with a case of a 40-day-old girl with kerion celsi caused by microsporum canis. the source of the infection were the parents who presented tinea corporis caused by m. canis. systemic treatment was carried out with terbinafine and complete recovery was achieved. tinea capitis is unusual in children during their first year of life and its evolution towards kerion is very rare in newborns. | 2004 | 15189191 |
| antifungal cobalt(ii), copper(ii), nickel(ii) and zinc(ii) complexes of furanyl-,thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins. | some novel cephalexin-derived furanyl, thiophenyl, pyrrolyl, salicylyl and pyridyl schiff's bases and their cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes have been synthesized and studied for their antifungal properties against trichophyton longifusus, candida albicans, aspergillus flavus, microsporum canis, fusarium solani and candida glaberata. the presence of metal ions in the investigated schiff's base complexes reported here lead to significant antifungal activity, whereas t ... | 2004 | 15202498 |
| development of an in vitro, isolated, infected spore testing model for disinfectant testing of microsporum canis isolates. | the isolated infected hair model is a commonly used technique to test the fungicidal efficacy of topical therapies against microsporum canis. the most commonly used model uses mats of infective hairs, and results from various laboratories have differed. the objectives of this study were to develop a method to produce spores for testing when only mycelial forms were available and to develop a semiquantitative testing method that used only infective spores from hairs, and not pooled hair samples f ... | 2004 | 15214954 |
| generalized microsporum canis dermatophytosis in six yorkshire terrier dogs. | six yorkshire terrier dogs with generalized, chronic dermatophytosis caused by microsporum canis were seen over a 3-year period. specific tests showed that they also had concurrent leishmaniosis (four cases), leishmaniosis and ehrlichiosis (one case) or diabetes mellitus (one case). although specific therapy for these infectious diseases was instituted and the dogs were treated systemically and topically with appropriate antifungal drugs, only partial clinical resolution of the dermatophytosis w ... | 2004 | 15214955 |
| intra- and interlaboratory study of a method for testing the antifungal susceptibilities of dermatophytes. | the national committee for clinical laboratory standards (nccls) m38-a standard for the susceptibility testing of conidium-forming filamentous fungi does not explicitly address the testing of dermatophytes. this multicenter study, involving six laboratories, investigated the mic reproducibility of seven antifungal agents tested against 25 dermatophyte isolates (5 blinded pairs of five dermatophyte species per site for a total of 300 tests), using the method of dermatophyte testing developed at t ... | 2004 | 15243047 |
| frequency and risk factors of dermatophytosis in students living in rural areas in eskişehir, turkey. | our study included 2384 students from five villages around eskişehir, turkey. we asked every student for their personal identification and also for their sanitation in order to get an idea about dermatophytosis. samples taken from suspicious lesion were collected and inoculated onto sabouraud dextrose agar slants. for identification of fungi which were grown, macroscopic appearance of colonies, microscopic examination and biochemical tests were used. we found suspicious lesions in 245 (10.3%) an ... | 2004 | 15281399 |
| itraconazole in the treatment of tinea capitis caused by microsporum canis: experience in a large cohort. | mycotic scalp infection caused by microsporum canis is one of the more recalcitrant disorders, with increasing incidence during the last decade. we report our experience with administration of itraconazole in 163 children (86 girls, 77 boys) with m. canis tinea capitis. fifty-five patients had previous treatment with terbinafine without success. in all children, the dosage of itraconazole was adjusted according to body weight, with 5 mg/kg/day given in a continuous regimen either as a capsule (1 ... | 2004 | 15283801 |
| [statistical study of dermatomycosis for 30 years (1968-1997) in sendai national hospital]. | a statistical study on dermatomycoses for the 30 years from 1968 to 1997 in the dermatologic section of sendai national hospital was carried out with the following results. the total number of dermatomycosis patients was 14,259 and accounted for 9.59% of all new outpatients during this period. these cases of dermatomycoses were composed of the following: dermatophytoses 10,656, candidiasis 3,287, malassezia infection 566, sporothrichosis 20, aspergillosis 7, and chromomycosis 1. annual changes i ... | 2004 | 15284829 |
| tinea capitis in a dermatology center in the city of fortaleza, brazil: the role of trichophyton tonsurans. | over a 3-year period (march 1999 to march 2002), 944 patients with scalp lesions attended a dermatology reference center in the city of fortaleza, ceará, brazil. clinical specimens were examined at the specialized medical mycology center, federal university of ceará, fortaleza-ce, brazil, to detect patients with tinea capitis. | 2004 | 15304180 |
| dermatophytoses in split and dalmatia, croatia, 1996-2002. | the aim of the study was to investigate the epidemiology of dermatophyte infections in split and dalmatia county, croatia, between 1996 and 2002. of 5792 samples 1318 (23.8%) were positive. tinea corporis and tinea cruris were the most common types of dermatophytoses. microsporum canis (36.5%), trichophyton mentagrophytes (24.8%), and t. rubrum (21.5%) were the main etiologic factors. | 2004 | 15310333 |
| dermatophytosis in children and adolescents in gdansk, poland. | during a 3-year period (1999-2001) a total of 94 cases of dermatophytosis were seen in patients from 0 to 18 years of age attending the department of dermatology, venerology and allergology of gdańsk medical university. mycoses were diagnosed on the basis of clinical picture and direct microscopy and were confirmed by positive cultures. the most frequent pathogens were microsporum canis (62%) and trichophyton rubrum (12%). the most often forms of dermatophytosis in children were tinea cutis glab ... | 2004 | 15310339 |
| the novel azole r126638 is a selective inhibitor of ergosterol synthesis in candida albicans, trichophyton spp., and microsporum canis. | r126638 is a novel triazole with in vitro activity similar to that of itraconazole against dermatophytes, candida spp., and malassezia spp. in animal models of dermatophyte infections, r126638 showed superior antifungal activity. r126638 inhibits ergosterol synthesis in candida albicans, trichophyton mentagrophytes, trichophyton rubrum, and microsporum canis at nanomolar concentrations, with 50% inhibitory concentrations (ic(50)s) similar to those of itraconazole. the decreased synthesis of ergo ... | 2004 | 15328084 |
| [identification of geophilic and zoophilic dermatophytes in siblings with tinea capitis. a pathogenic factor or contamination?]. | two siblings of african origin presented with multiple scaling patches and alopecia on the scalp four weeks after returning from a vacation in eritrea. direct koh examination revealed fungal elements; trichophyton mentagrophytes and trichophyton terrestre were identified in the fungal culture. we discuss the putative pathogenic role of both microorganisms in causing disease. although infection with microsporum canis currently accounts for almost fifty percent of all cases of tinea capitis in ger ... | 2004 | 15340708 |
| in vitro antifungal activity of sertaconazole against 309 dermatophyte clinical isolates. | three hundred and nine strains belonging to 11 species of dermatophyte moulds were tested against sertaconazole following mainly the national committee for clinical laboratory standards (m38-p) for filamentous fungi. however, several important factors such as the temperature (28 degrees c vs 35 degrees c) and time of incubation (4-10 d vs 21-74 h), have been modified. sertaconazole was active against all the clinically important dermatophyte moulds involved in human infections tested. overall ge ... | 2003 | 14998079 |
| tinea barbae (tinea sycosis): experience with nine cases. | tinea barbae is a rare dermatophytosis that affects the hair and hair follicles of the beard and mustache. this paper presents 9 cases of tinea barbae observed over an 18-year period of time and classified as follows: 1 was superficial and 8 were deep (6 folliculitis-like and 2 kerion-like). most of the cases (4) were associated with topical steroid therapy, others with pet contact (3 cases) and one with diabetes. the causal agents isolated were: trichophyton rubrum in 3; microsporum canis in 3; ... | 2003 | 14739517 |
| tinea capitis among children and adolescents in the farwaniya region of kuwait. | analysis of 325 patients (182 males, 143 females) of mycologically proven tinea capitis (tc) seen over a period of two years from january 2001--december 2002 in the farwaniya region of kuwait is presented in this study. the age range was 8 months to 17 years. peak incidence was observed in the 3-14 year age group (79.6%). positive family history and contact with pets were noted in 22% and 36.7% of the cases, respectively. the non-inflammatory 'gray patch' variety was the most common clinical typ ... | 2003 | 14739518 |
| dermatophyte agents in the city of são paulo, from 1992 to 2002. | dermatophytosis are superficial mycoses caused by fungi that can invade stratum corneum and keratinized tissues. in order to study the frequency of dermatophytes species and the clinical manifestations caused by these fungi, in são paulo, sp, brazil, the authors analyzed cultures isolated at the mycology laboratory from a selected population (15,300 out-patients of the hospital das clínicas, department of dermatology, faculty of medicine of university of são paulo) from january 1992 to june 2002 ... | 2003 | 14743665 |
| a recombinant 31.5 kda keratinase and a crude exo-antigen from microsporum canis fail to protect against a homologous experimental infection in guinea pigs. | a microsporum canis recombinant 31.5 kda keratinase and a m. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. animals were vaccinated subcutaneously three times at two-week intervals with either the keratinase, the exo-antigen or the adjuvant alone. cutaneous challenge was performed blindly. both humoral and cellular-specific immune responses to m. canis antigens were evaluated every 14 days, while a blind evaluation of clinical lesion developmen ... | 2003 | 14678442 |
| epidemiology of dermatophytoses in an area south of tehran, iran. | dermatophyte infections have been considered to be a major public health problem in many parts of the world. the aim of this study was to identify the etiological and epidemiological factors of dermatophyte infections in an area south of tehran. a total of 1254 patients suspected to have dermatophytic lesions were examined over a period of three years (1999-2001). material collected from skin, hair, and nails was submitted to direct microscopic examination using koh, cultured in sabouraud dextro ... | 2003 | 14682452 |
| occurrence of dermatomycoses and in-vitro therapeutic efficacy of three antifungal drugs on the growth of epidermophyton floccosum. | the occurrence of dermatomycoses and the in-vitro therapeutic efficacy of some antifungal agents on dermatomycotic organisms were investigated. of the 550 primary school children screened, the incidence was one hundred (18%), 70 were males (representing 20% of the males screened) and 30 females (15% of the females sampled). the differences between male and female prevalence were insignificant. three species of dermatophytes were isolated and identified. these were microsporum canis, trichophyton ... | 2003 | 14682454 |
| high rate of microsporum canis feline and canine dermatophytoses in northeast brazil: epidemiological and diagnostic features. | over a one year period (november 2000-december 2001), clinical specimens from 189 dogs and 38 cats, from the city of fortaleza, ceará, brazil, were examined at the specialized medical mycology center at the federal university of ceará to detect animals with dermatophytoses. the mycological analyses were conducted by direct microscopy and by fungal culture on sabouraud agar, sabouraud chloramphenicol agar and mycosel agar. dermatophytes were isolated from 27 of the 189 (14.3%) canine specimens an ... | 2003 | 14682455 |
| humoral and cellular immune response to a microsporum canis recombinant keratinolytic metalloprotease (r-mep3) in experimentally infected guinea pigs. | in order to better understand the host-fungus relationship in microsporum canis dermatophytosis and to identify major fungal antigens, the immune response to a crude exoantigen preparation and to a purified recombinant keratinolytic metalloprotease (r-mep3) was evaluated in guinea pigs experimentally infected with m. canis. humoral and cellular immune responses were assessed from day 0 to day 57 post-infection (pi), the former by enzyme-linked immunosorbent assay (elisa) and the latter via a lym ... | 2003 | 14725323 |
| constituents of the argentinian medicinal plant baccharis grisebachii and their antimicrobial activity. | the resinous exudate of baccharis grisebachii which is used to treat ulcers, burns, and skin sores in argentina showed activity towards dermatophytes and bacteria. two diterpenes, eight p-coumaric acid derivatives, and two flavones were isolated from the exudate and the structures elucidated by spectroscopic methods. 3-prenyl-p-coumaric acid and 3,5-diprenyl-p-coumaric acid were active towards epidermophyton floccosum and trichophyton rubrum with mics of 50 and 100-125 microg/ml, respectively. t ... | 2003 | 14522435 |
| [epidemiological survey of dermatophytosis in spain (april-june 2001)]. | a three-month (april-june 2001) cross-sectional study was designed to assess the epidemiological profile of dermatophytosis in spain. | 2003 | 14572379 |
| [in vitro activity of voriconazole and three other antifungal agents against dermatophytes]. | the increase in infections due to dermatophytes in recent years led us to study the effectiveness of new antifungal formulations against these microorganisms. | 2003 | 14572380 |
| [current types of human dermatophytoses transmitted from animals]. | microsporum canis, trichophyton verrucosum and t. mentagrophytes are the most common dermatophytes isolated from human and animals. m. canis infection in human is closely related to companion animals such as cats and dogs. according to a recent epidemiological survey in japan, human m. canis infection is decreasing. t. verrucosum is usually transmitted from cows to human. t. verrucosum infection in human is not restricted to daily farming prefectures, however, suggesting that this species has al ... | 2003 | 14615787 |
| epidemiology of dermatophyte infection in auckland, new zealand. | this report describes the epidemiology of culture-proven dermatophyte infection in auckland, new zealand. the authors undertook a retrospective review of laboratory data for the period from june 1999 to july 2002. there were 10 004 dermatophyte isolates. the most common isolates were trichophyton rubrum (69%) and trichophyton mentagrophytes (19%). microsporum canis was mainly isolated from children. the prevalence of t. mentagrophytes increased with patient age (p < 0.001). trichophyton rubrum w ... | 2003 | 14616492 |
| environmental detection of microsporum canis arthrospores in the households of infected cats and dogs. | microsporum canis is the dermatophyte most frequently recovered from canine and feline ringworm cases. the household environment can be contaminated both by symptomatic animals and through asymptomatic m canis carriage, resulting in a potential human health risk. the load of m canis arthrospores was determined in households harbouring infected pets, in order to evaluate the infectivity of the animals versus the environment. the environments inhabited by 30 symptomatic animals (21 cats and 9 dogs ... | 2003 | 14623201 |
| action mechanisms of modern antifungal agents and resulting problems in the management of onychomycosis. | successful treatment of onychomycosis in the infection site depends not only on achieving the minimal inhibitory concentration (mic) of the antifungal agent, usually determined on fresh, proliferating fungal strains, but also on the effectivity against fungal spores dormant in nail keratin. ciclopiroxolamine and terbinafine were investigated for their fungicidal properties against proliferating and dormant dermatophyte strains. while ciclopiroxolamine was 100% effective against trichophyton ment ... | 2003 | 14641625 |
| dermal mass aspirate from a persian cat. | a 1-year-old spayed female persian cat with alopecia and weight loss had numerous variably ulcerated dermal nodules. cytologic examination of an aspirate of one of the nodules revealed pyogranulomatous inflammation along with septate hyphae and basophilic round bodies, 0.5-1.0 microm in diameter, surrounded by a thin clear halo (arthrospores). the cytologic diagnosis was dermatophytic pseudomycetoma. histologically, there were dermal granulomas containing poorly staining, septate hyphae with bul ... | 2003 | 14655108 |
| in vitro antagonistic activity of monoterpenes and their mixtures against 'toe nail fungus' pathogens. | the antibiotic effect of the active ingredients in meijer medicated chest rub (eucalyptus oil, camphor and menthol) as well as the inactive ingredients (thymol, oil of turpentine, oil of nutmeg and oil of cedar leaf) were studied in vitro using the fungal pathogens responsible for onychomycosis, such as the dermatophytes tricophyton rubrum, trichophyton mentagrophytes, microsporum canis, epidermophyton fl occosum and epidermophyton stockdale. the zones of inhibition data revealed that camphor (1 ... | 2003 | 12722144 |
| effects of lufenuron treatment in cats on the establishment and course of microsporum canis infection following exposure to infected cats. | to determine effects of lufenuron treatment in cats on the establishment and course of microsporum canis infection following exposure to infected cats. | 2003 | 12725307 |
| fluorescent method for studying the morphogenesis and viability of dermatophyte cells. | the dermatophyte microsporum canis is commonly isolated from human and animal infection. the morphogenesis of this fungus was studied during its developmental stages through the fluorescent method fluorescein diacetate and ethidium bromide. to this end, 50 microl dermatophyte suspension were transferred onto cellophane wrapping esterilized discs (2.5 cm of diameter) placed over the surface of sabouraud dextrose agar on petri dishes and incubated at 25 degrees c for 30 days. every 60 minutes duri ... | 2003 | 12733625 |
| the prevalence of immediate and delayed type hypersensitivity reactions to microsporum canis antigens in cats. | spontaneous recovery from microsporum canis infections in cats is thought to be dependent on the development of a competent immune response. the purpose of this study was to determine the prevalence of positive delayed type hypersensitivity reactions in cats with and without dermatophytosis. four groups of cats were intradermally skin tested with m canis extract and test sites were evaluated both subjectively and objectively at 0, 24 and 48 h after injection. delayed intradermal testing (idt) re ... | 2003 | 12765626 |
| dermatomycoses in the rijeka area, croatia, before, during and after the war 1990-1999. | the frequency of dermatomycoses as well as the spectrum of causative agents in the rijeka area, northwestern part of croatia, in the periods before and during the war (1990-1994) and in the postwar period (1995-1999) were analyzed. a total of 20 463 patients with clinically suspected dermatomycoses referred to the department of dermatovenerology, clinical hospital center rijeka, was examined. in the period from 1990 till 1994, 2462 samples were positive, compared with 2250 positive samples durin ... | 2003 | 12801365 |
| prevalence of tinea capitis in primary schools in turkey. | the aim of our study was to determine the prevalence of tinea capitis in middle anatolia. between february 2000 and april 2000, a school survey of 4760 primary school children was carried out and 34 cases of tinea capitis were clinically diagnosed. sixteen (0.3%) of them were diagnosed both clinically and using culture. eighteen cases (52.9%) were diagnosed microscopically whereas the remaining 16 cases (47.0%) had a clinical diagnose. we also isolated and identified the following species of fun ... | 2003 | 12801366 |
| dermatophytes isolated from domestic animals in iran. | between 1994 and 1998, a total of 790 feather, hair and skin specimens from a variety of animals with suspected dermatophytoses were studied, of which 248 (31.4%) yielded dermatophytes. the most frequent dermatophytes isolated were microsporum canis (38.3%), trichophyton verrucosum (31.8%), t. mentagrophytes (13.3%) and m. gypseum (7.7%). there was a significantly higher proportion of positive cultures from cats (54.8%) than dogs (8.2%), and m. canis was the most common species isolated (87.2 an ... | 2003 | 12801367 |
| [prevalence of zoophilic dermatophytes in the sarajevo region]. | zoophlic dermatophytes are common cause of tinea infections in europe, especially in mediterranean area. the aim of our study was to determine the prevalence of zoophilic dermatophytes in sarajevo area, during a five-year period (1998-2002). samples (skin scrapings or nail fragments) were taken from 2,142 patients who presented with suspected dermatophytoses and cultured on sabouraud agar. after three weeks of incubations 465 (21.7%) dermatophytes were identified based on macroscopic and microsc ... | 2003 | 12822383 |
| antifungal activity of the methanolic extract and alkaloids of glaucium oxylobum. | the methanolic extract and total alkaloids of the aerial parts of glaucium oxylobum exhibited good activity against microsporum gypseum, microsporum canis, trichophyton mentagrophytes and epidermophyton floccosum. four alkaloids, dicentrine, glaucine, protopine, and alpha-allocryptopine, were identified as the compounds responsible for the antifungal activity of this plant. | 2003 | 12837370 |
| onychomycosis in systemic lupus erythematosus: a case control study. | immunosuppressed patients are prone to develop onychomycosis. in systemic lupus erythematosus (sle) there are no previous studies. we aimed to establish the prevalence, clinical characteristics, and organisms causing onychomycosis in sle patients compared with controls. | 2003 | 12858446 |
| inhibition of dermatophytes by optical brighteners. | the aim of this study was to investigate a possible effect of optical brighteners on the growth of dermatophytes. typical strains of trichophyton rubrum, t. mentagrophytes, microsporum canis and epidermophyton floccosum were grown on agar plates containing two different brighteners of stilbenedisulfonic acid type in concentrations between 5 x 10(-5) and 1 x 10(-2) mol l-1 and their thallus diameters were compared with controls. in addition, hyphae grown with brighteners were compared with contro ... | 2003 | 12870200 |
| recombinant expression and antigenic properties of a 31.5-kda keratinolytic subtilisin-like serine protease from microsporum canis. | a secreted 31.5-kda keratinolytic subtilase (sub3; aj431180) is thought to be a microsporum canis virulence factor and represents a candidate for vaccination trials. in this study, the recombinant keratinase (r-sub3) was produced by the pichia pastoris expression system and purified to homogeneity. recombinant sub3 displayed identical biochemical properties with the native protease. experimentally cutaneously infected guinea pigs showed specific lymphoproliferative response towards r-sub3, while ... | 2003 | 12900052 |
| [analysis of dermatophyte flora at a private clinic in sapporo during the period 1992 to 2001]. | statistical analysis was made of a total of 5530 patients (6798 cases) of dermatophytoses presenting at our private clinic during the period 1992 to 2001. the number of patients and cases represents 8.0% and 9.8% of the entire outpatient population during that time, respectively. sex ratio (male/female) was 1.5. among the 6798 dermatophytoses cases, tinea pedis was most frequent (65.8%), followed by tinea unguium (20.7%), tinea cruris (7.2%), tinea corporis (3.9%), tinea manuum (2.4%) and tinea ... | 2003 | 12913811 |
| presence of dermatophytes on the nails of tinea capitis patients. prospective study in the area of sfax (tunisia). | between january 1995 and december 2000, 512 cases with mycologically confirmed tinea capitis have been diagnosed in our laboratory. in addition, finger nail samples have been taken from 211 patients out of 512. the culture of the nail samples taken was positive for 80 patients (38%). the isolated dermatophytes were the same in the nails and the scalp. microsporum canis was isolated in 82% of nail samples. trichophyton violaceum grew only in 18% and trichophyton quinckeanum in one case. a t. viol ... | 2003 | 12950904 |
| [tinea capitis et corporis due to microsporum canis in an immunocompromised female adults patient]. | tinea capitis as well as tinea corporis in adults may occur under conditions of immunosuppression. if suspected clinically, direct microscopy and examination by culture is indispensable. therapeutic intervention should start without delay. a proven fungal infection of scalp hairs warrants immediate initiation of systemic treatment. hereby prevention of disfiguring hair loss, permanent formation of scar tissue, spread of fungal organisms to other cutaneous regions as well as infection of other pe ... | 2003 | 12955848 |
| bioactive alkyl phenols and embelin from oxalis erythrorhiza. | the benzoquinone embelin and four alkyl phenols were isolated from an argentinean collection of oxalis erythrorhiza. 3-heptadecyl-5-methoxy-phenol is reported for the first time. the structures were determined by spectroscopic methods. embelin presented inhibitory effect on methicillin-resistant staphylococcus aureus, escherichia coli and the dermatophytic fungi epidermophyton floccosum, microsporum canis, microsporum gypseum, trichophyton mentagrophytes and trichophyton rubrum with mics ranging ... | 2003 | 12963150 |
| tinea capitis in cleveland: survey of elementary school students. | tinea capitis, a fungal infection of the scalp, is of increasing public health importance, and trichophyton tonsurans has become the primary causative agent in north america. | 2003 | 12582387 |
| synergistic inhibition of the growth in vitro of microsporum canis by miconazole and chlorhexidine. | an agar dilution technique was used to assess the minimum inhibitory concentrations (mic) of miconazole, chlorhexidine and a 1:1 combination of both agents for 10 isolates of microsporum canis. for nine of 10 of the isolates, a combination of miconazole and chlorhexidine was more effective than either agent alone; fractional inhibitory concentration indices indicated a synergistic effect for five isolates and an additive effect for four. these results illustrate the potent antimycotic effect of ... | 2003 | 12662267 |
| characteristics of superficial mycoses in malta. | a study was conducted to determine the chief agents of superficial mycoses in malta. data were collected over a 5-year period from mycologic investigations carried out on all dermatologic specimens sent to the mycology laboratory at st. luke's hospital in malta. | 2003 | 12694490 |
| in vitro antimicrobial activity of ethanol and water extracts of cassia alata. | crude ethanol and water extract of leaves and barks from cassia alata were tested in vitro against fungi, (aspergillus fumigatus and microsporum canis), yeast (candida albicans) and bacteria (staphylococcus aereus and escherichia coli). c. albicans showed concentration-dependent susceptibility towards both the ethanol and water extracts from the barks, but resistant towards the extracts of leaves. the degree of susceptibility varied, the water extract from barks showed bigger inhibition zone tha ... | 2003 | 12499068 |
| study of the dermatophytes in dogs and the risk of human infection. | the infiltrative growth of fungi that multiplies in the tissues (dermatophytes, candida, agents of visceral mycoses) is the generally known proof of "active" functioning of these organisms. the relative importance of fungi as inducers of human and animal diseases grows constantly. | 2003 | 15168865 |
| [dermatophyte infection and colonization in dogs from south santiago, chile]. | our main aim was to determine the dermatophyte infection and colonization prevalence in canines from south santiago, chile. we studied 241 dogs, 121 of them presented cutaneous lesions suggestive of dermatophytosis and the other 120 were free from lesions and were considered clinically healthy. dermatophytes were isolated from the lesions of 48.8% of animals with cutaneous diseases and from 5% of healthy dogs. microsporum canis was the principal species isolated with a frequency of 98.3% from de ... | 2003 | 15456352 |
| [tinea capitis in children from goiânia, brazil]. | during the period january 1999 to july 2002 a total de 164 cases of tinea capitis were diagnosed by mycological examination in instituto de patologia tropical e saúde pública of the universidade federal de goiás. of the 164 patients 94 (57.3%) were males, with an age of 3 months to 13 years. laboratory studies were performed by direct examination with 20% koh and cultivated on mycobiotic agar medium and sabouraud dextrose agar with chloramphenicol. the following species were identified: microspo ... | 2003 | 15049102 |
| fluconazole in the treatment of pediatric tinea capitis caused by microsporum canis. | fluconazole has been shown to be effective in the treatment of fungal scalp infections in children; however, there is limited experience of its use in microsporum scalp infections. we studied 11 children with tinea capitis caused by microsporum canis who received oral fluconazole at a dose of 5-7.5 mg/kg/day for 6 weeks. mycological cure was observed in two of the 11 patients at week 4 from the start of therapy, in four patients at week 8 and in three patients at week 16. one of the remaining pa ... | 2002 | 12512234 |
| dermatophytes isolated from symptomatic dogs and cats in tuscany, italy during a 15-year-period. | between january, 1, 1986 and december, 31, 2000, dermatological specimens from 10.678 animals (7.650 cats and 3.028 dogs) were examined for dermatophytes. all the animals presented clinical signs of ringworm. two thousand-four hundred fifty-six of the 10.678 (23%) examined animals scored positive for dermatophytes, 566 out of 3.028 canine (18.7%) and 1890 out of 7.650 feline specimens (24.7%). microsporum canis constituted 83% and 97% of the isolated dermatophytes respectively in dogs and cats, ... | 2002 | 12715942 |
| [clinical and epidemiological survey of dermatophytoses in jaen (spain)] | prevalence of dermatophytosis, with respect to age and sex and dermatophyte species, in jaen was investigated during a period of three years (1996-1999). the prevalence of dermatophytosis over three years was 4.48 cases / 1000 inhabitants. the isolated species were: microsporum canis (48.6%), trichophyton mentagrophytes (27.1%), epidermophyton floccosum (10%), trichophyton rubrum (8.6%), trichophyton violaceum (4.3%), and microsporum gypseum (1.4%). the most frequently observed dermatophytoses w ... | 2002 | 12716229 |
| [three years incidence of dermatophytes in a hospital in porto (portugal)]. | we evaluated the incidence of dermatophytes isolated at our hospital in the years of 1997 to 2000 and correlated it with anatomical site and age. trichophyton rubrum was the predominant species in all anatomical sites, excluding scalp, followed by microsporum canis, the leading agent of tinea capitis. all dermatophytosis, except tinea capitis by m. canis and trichophyton schoenleinnii appeared mainly in adult patients. our results revealed no substantial differences to other portuguese studies r ... | 2002 | 12825982 |
| further evaluation of rwandan medicinal plant extracts for their antimicrobial and antiviral activities. | a total of 45 rwandan plant extracts, belonging to 37 different plant species out of 21 families, were investigated for their antibacterial, antifungal, and antiviral properties. the plants were selected on the base of their ethnomedicinal use against infections and autoimmune diseases. from all the plant extracts tested, only clematis hirsuta (leaves) showed a pronounced antifungal activity against candida albicans and the dermatophytes trichophyton rubrum, epidermophyton floccosum, and microsp ... | 2002 | 11801376 |
| case report. tinea corporis due to microsporum canis in a professional cyclist. | we report the case of a 20-year-old man, a professional cyclist, with multiple scaling plaques on his limbs that had been present for 40 days. our case of tinea corporis presented some peculiarities related to the aetiological agent microsporum canis and also its mode of transmission. | 2002 | 11856439 |
| topical treatment of tinea capitis in a neonate. | tinea capitis is the most common fungal skin infection in children. given that this infection invades the hair shaft and the pilosebaceous unit, systemic antifungal therapy is the gold standard of treatment. despite the neonate's increased susceptibility to infections, tinea capitis is rare in this population. we present the case of a 16-day-old infant with tinea capitis caused by microsporum canis and effectively treated with topical bifonazole 1%. | 2002 | 11868981 |
| [epidemiology and etiology of dermatophytosis in goiânia, go, brazil]. | dermatophytes are a group of closely related fungi that have the capacity to invade keratinized tissue (skin, hair, and nails) of humans and animals to produce infections called dermatophytosis. in order to review the etiology and epidemiology of dermatophytosis in goiânia, go, 1955 specimens with diagnostic suspicion of dermatophytic lesions, were collected from january to december, 1999, from the mycology laboratory in the institute of tropical pathology and public health, federal university o ... | 2002 | 11873256 |
| evaluation of topically applied enilconazole for the treatment of dermatophytosis in a persian cattery. | many persian catteries have long-standing dermatophyte infections and are particularly difficult to treat. enilconazole is a topical antifungal agent that has demonstrated good efficacy in recent studies. twenty-two persian cats naturally infected with microsporum canis in a breeding cattery were treated with topical 0.2% enilconazole and monitored for 180 days. the treatments were repeated every 3 days for a total of eight applications. all the cats improved clinically and became culture negati ... | 2002 | 11896967 |
| synthesis of variously 9,9-dialkylated octahydropyrimido [3,4-a]-s-triazines with potential antifungal activity. | 9,9-dialkyloctahydropyrimido[3,4-a]-s-triazines were synthesized by iminodimethylation reaction between a 5,5-dialkyl-6-aminopyrimidine-2.4(3h,5h)-dione, a substituted aniline and two moles of formaldehyde. the synthesis of.5,5-dialkyl-6-aminopy-rimidinedione consisted of the condensation of urea with ethyl 2,2-dialkylcyanoacetates. 18 octahydropyrimido[3,4-a]-s-triazines were synthesized and compounds resulting from a supplementary aminomethylation were also obtained. most of these compounds we ... | 2002 | 11902652 |
| trichophyton violaceum is the dominant cause of tinea capitis in children in tripoli, libya: results of a two year survey. | the causative agents of tinea capitis in libyan nationals attending the out patient dermatology clinic of the tripoli medical centre over the period december 1997 to december 1999 were investigated. samples (hair and scalp scrapings) were taken from 940 patients who presented with suspected tinea capitis. the etiological agents were identified in 584 cases. trichophyton violaceum was found to be the most prevalent organism isolated being responsible for 64.4% (376/584) of culture positive cases, ... | 2002 | 11998877 |
| dermatophytes and other fungi associated with skin mycoses in tripoli, libya. | this study sought to determine the prevalence of skin infections and their causative agents in the libyan population. samples were collected from 2224 patients attending the dermatology clinics of the tripoli medical centre (tmc) between august 1997 and december 1999 and were submitted to a mycology laboratory for analysis. diagnosis was confirmed by microscopic examination in 1180 cases (53.1%) and the causative agent was isolated and cultured in 1160 cases (52.2%). dermatophytes, malassezia fu ... | 2002 | 12000510 |
| a study of dermatophytoses in sana'a, yemen republic. | the present study describes the extent and causative agents of dermatophytoses in sana'a, the capital of yemen republic. out of 1100 patients with various skin diseases, 16.6% were affected with dermatophytoses. among them, 70% were male and the age group 11-20 years was most susceptible to tinea infections. tinea corporis was the most common disease, followed by tinea capitis. one hundred and seventy isolates of dermatophytes related to 9 species were identified. microsporum canis was the most ... | 2002 | 12000511 |
| case report. rosacea-like tinea incognito. | we report a case of dermatophytosis of the face due to microsporum canis that was exacerbated and altered clinically by a long-term application of topical corticosteroids. we considered this case a rosacea-like tinea incognito of the beard area. | 2002 | 12000520 |
| drug efficacy of terbinafine hydrochloride (lamisil) during oral treatment of cats, experimentally infected with microsporum canis. | cats represent a primary source of microsporum canis infections in humans. terbinafine hydrochloride (lamisil) is commonly used in the treatment of microsporosis in humans as its fungicidal action permits short periods of treatment. the aim of the present study was to estimate the efficacy of the drug in cats. nine cats were experimentally infected with m. canis and treated with terbinafine hydrochloride at a dose of 10-20 mg/kg (once daily, sid; low-dose group, ldg). another nine cats were simi ... | 2002 | 12019941 |
| proximal white subungual onychomycosis caused by microsporum canis in systemic lupus erythematosus. | we report the case of a mexican lupus patient who developed proximal white subungual onychomycosis on multiple toenails. microsporum canis was the causative agent. both nail invasion by m. canis and proximal white subungual onychomycosis are rare conditions indicative of an underlying immunodeficiency. | 2002 | 12036214 |
| in vitro susceptibility of microsporum canis and other dermatophyte isolates from veterinary infections during therapy with terbinafine or griseofulvin. | we investigated the in vitro activity of terbinafine against fresh veterinary isolates of microsporum canis and the potential of this organism to develop resistance in vivo during oral therapy. dermatophyte cultures (n = 300) were obtained from naturally infected cats and dogs undergoing oral therapy with terbinafine or griseofulvin. m. canis comprised 92% of isolates; other species included microsporum gypseum and trichophyton mentagrophytes. minimum inhibitory concentrations (mics) and minimum ... | 2002 | 12058731 |
| yeasts of the genus candida are the dominant cause of onychomycosis in libyan women but not men: results of a 2-year surveillance study. | the reported frequency of recovery of fungi from infected nails varies according to the geographical area. | 2002 | 12072073 |
| evaluation of the efficacy of oral lufenuron combined with topical enilconazole for the management of dermatophytosis in catteries. | the efficacy of oral lufenuron, a chitin synthetase inhibitor, combined with topical enilconazole, was evaluated for the management of microsporum canis infection in 100 cats housed in two catteries in france. the cats were treated with weekly rinses with enilconazole (0.2 per cent) for four weeks and, in each cattery, one group (a) was also treated with micronised griseofulvin (25 mg/kg administered orally twice a day for five weeks) and a second group (b) was treated with 60 mg/kg lufenuron ad ... | 2002 | 12081306 |
| use of the sensititre colorimetric microdilution panel for antifungal susceptibility testing of dermatophytes. | the sensititre yeastone antifungal panel was used to test 49 dermatophytes belonging to the species epidermophyton floccosum, microsporum gypseum, microsporum canis, trichophyton tonsurans, trichophyton rubrum, and trichophyton mentagrophytes. the mics of four antifungals obtained with the sensititre yeastone antifungal panel were compared with those obtained by the reference nccls microdilution method. the levels of agreement between the two methods (<or=2 dilutions) were 81.6% with amphoterici ... | 2002 | 12089289 |
| [morphological study of human hair infected with microsporum canis]. | some aspects in forensic medical examination of hairs damaged by microsporum canis are discussed. the data of microscopic, fluorescent, and serological studies of damaged hairs and methods for their examination are presented. | 2002 | 12165955 |
| terbinafine: efficacy and tolerability in young children with tinea capitis due to microsporum canis. | we carried out an open, prospective, uncontrolled study to evaluate the efficacy and tolerability of terbinafine in the treatment of young children with tinea capitis due to microsporum canis. | 2002 | 12195561 |
| survey of dermatophyte infections in the lausanne area switzerland. | the dermatophytes are important in the swiss medical environment since 5-10% of consultations in dermatology concern mycotic infections. | 2002 | 12218248 |
| secreted metalloprotease gene family of microsporum canis. | keratinolytic proteases secreted by dermatophytes are likely to be virulence-related factors. microsporum canis, the main agent of dermatophytosis in dogs and cats, causes a zoonosis that is frequently reported. using aspergillus fumigatus metalloprotease genomic sequence (mep) as a probe, three genes (mep1, mep2, and mep3) were isolated from an m. canis genomic library. they presented a quite-high percentage of identity with both a. fumigatus mep and aspergillus oryzae neutral protease i genes. ... | 2002 | 12228297 |
| unusual presentation of microsporum canis in human hair. | this study reports an unusual presentation of microsporum canis in infected human hair in a three-year-old boy. infected hairs showed ectothrix colonization with a mass of small conidia and numerous macroconidia typical of the genus microsporum. the infected hairs also showed strong invasion by hyphae bearing small numbers of arthroconidia. these hyphae were thinner and longer than those normally found in hair and scalp. it is well known that in cases of tinea capitis due to m. canis, ectothrix ... | 2002 | 12230223 |
| chemical analysis and antifungal activity of the essential oil of calea clematidea. | the chemical composition of the essential oils of calea clematidea baker obtained by hydrodistillation of the leaves and flowers was analysed by gc and gc/ms and the oils were assayed for their antifungal activities. the essential oil of the leaves showed a high content of a new natural epoxy terpenoid, named clemateol (ca. 70 %), with minor amounts of o-vanillin (6.5 %), spathulenol (4.2 %), alpha-terpinene (4.0 %), germacrene b (2.9 %), yomogi alcohol (1.8 %), ( e)-caryophylene (1.7 %), m-cyme ... | 2002 | 12357399 |
| antifungal evaluation of bis mannich bases derived from acetophenones and their corresponding piperidinols and stability studies. | the development of resistance to current antifungal therapeutics drives the search for effective new agents. the fact that some acetophenone-derived mannich bases had shown antifungal activities in our previous studies led us to design and synthesize acetophenone-derived bis mannich bases, b1-b5, bis(beta-aroylethyl)methylamine hydrochlorides, to evaluate their antifungal activity. these bis mannich bases were then converted to the corresponding piperidinols, c1-c5, which are structural isomers ... | 2002 | 12392084 |
| isolation of a microsporum canis gene family encoding three subtilisin-like proteases expressed in vivo. | microsporum canis is the main agent of dermatophytosis in dogs and cats and is responsible for frequent zoonosis. the pathogenesis of the disease remains largely unknown, however. among potential fungal virulence factors are secreted keratinolytic proteases, whose molecular characterization would be an important step towards the understanding of dermatophytic infection pathogenesis. m. canis secretes a 31.5 kda keratinolytic subtilisin-like protease as the major component in a culture medium con ... | 2002 | 12406327 |
| safety and immunologic effects after inoculation of inactivated and combined live-inactivated dermatophytosis vaccines in cats. | to determine antidermatophyte immunologic effects of an experimental combined live-inactivated dermatophytosis vaccine (clidv) and a commercial inactivated dermatophytosis vaccine (idv) in cats and to evaluate adverse effects associated with administration of these vaccines. | 2002 | 12428663 |
| fluconazole downregulates metallothionein expression and increases copper cytotoxicity in microsporum canis. | azole antifungals are widely used to treat infections with dermatophyte fungi. whereas it is well established that this class of drugs interferes with fungal ergosterol synthesis, little is known about its potential other biological effects. here we report the isolation and structural organization of microsporum canis metallothionein gene and demonstrate that fluconazole is able to downregulate the baseline as well as copper-induced expression of this gene. since this effect occurred within 30 m ... | 2002 | 12470632 |
| involvement of tnf-alpha changes in human cancer development, prevention and palliative care. | cancer development and ageing are complex sciences. from the study on the process of rodent carcinogenesis, we identified tumor necrosis factor-alpha (tnf-alpha) as an important mediator of cancer development. this paper presents three clinical examples of tnf-alpha up-regulation: by cord factors of mycobacterium tuberculosis, such as trehalose 6-monomycolate, as an activator of protein kinase c and by a cord factor like fraction of microsporum canis obtained in the air inside houses in thailand ... | 2002 | 12470903 |
| production of extracellular enzymes by microsporum canis and their role in its virulence. | microsporum canis is the most prevalent dermatophyte of domestic animals. several enzymes produced by dermatophytes, particularly keratinases, are considered to play a role in the virulence of this fungus. to investigate the possible relationship between the clinical status of m. canis infection and enzymatic activity of isolates, we studied the relationship between keratinase, elastase, lipase and dnase levels produced in vitro by different isolates and virulence as expressed in a guinea pig mo ... | 2001 | 12054058 |
| [fungistatic activity of a sesquiterpene lactone (tomentosin) isolated from fresh inula viscosa (asteraceae) flowers from the puglia region]. | a sesquiterpene lactone, tomentosin, has been isolated and identified form inula viscosá ait (asteraceae) flowers. the molecule, at 1 mg/ml concentration, showed to be active in vitro against microsporum canis, microsporum gypseum and trichophyton mentagrophytes. | 2001 | 11921538 |
| phenotypic characterization of microsporum canis isolated from cats and dogs. | to characterize strains of microsporum canis that infect dogs and cats in são paulo city, 30 isolates of this dermatophyte were tested for their ability to assimilate carbon and nitrogen sources, for proteinase and phospholipase secretion, for susceptibility to yeast killer toxins, and for susceptibility to the antifungals fluconazole, ketoconazole, itraconazole, 5-fluorocytosine and amphotericin b, in e test. all samples assimilated the nitrogen sources asparagine, ammonium sulphate, urea and s ... | 2001 | 11820261 |
| dermatophytoses in prague, czech republic, between 1987 and 1998. | over a 12-year period, from 1987 to 1998, the spectrum of aetiological agents isolated from 11208 patients (6265 females and 4943 males) suspected of having dermatomycosis was analysed in the mycological laboratory of the department of dermatology, charles university, prague. the most frequently examined locations were toenails (34.9%), feet (15.6%), fingernails (12.8%), toe webs (11%), trunk (10%) and hands (8.7%). dermatophytes were isolated from 5605 (30.2%) of all 18528 samples examined. amo ... | 2001 | 11820263 |
| synthesis of some 4-(alkylidene/arylidene)amino-2,4-dihydro-5- (2-thienyl)-3h-1,2,4-triazole-3-thiones tested for antimicrobial activity. | a series of 4-(alkylidene/arylidene)amino-2,4-dihydro-5- (2-thienyl)-3h-1,2,4-triazole-3-thiones (2a-h) were synthesized. the structural elucidation of all the compounds was made on the basis of analytical and spectral data (ir, 1h-nmr and eims). all synthesized compounds were evaluated for in vitro antimicrobial activity against various bacteria and fungi. some of the compounds demonstrated antimicrobial activity against staphylococcus aureus atcc 6538, staphylococcus epidermidis atcc 12228, tr ... | 2001 | 11822231 |
| tinea capitis in infants less than 1 year of age. | tinea capitis is the most frequent manifestation of dermatophyte infection in children, but because it is rare in the first months of life it is often misdiagnosed. here we report 15 cases of tinea capitis observed in italy in infants less than 1 year of age. there were 10 boys and 5 girls (mean age 6 months). diagnosis was confirmed by mycologic examination. microsporum canis was isolated in nine cases and trichophyton mentagrophytes in three. these 12 infants were italian and animals were the ... | 2001 | 11841628 |
| itraconazole is effective in the treatment of tinea capitis caused by microsporum canis. | tinea capitis is a relatively common superficial fungal infection in children which requires oral antifungal therapy. in a prospective, open study over 24 weeks, itraconazole 5 mg/kg/day, given as capsules or as an oral suspension for a period of 2-12 weeks, was used to treat children 1-12 years of age who had m. canis tinea capitis. children with mycologic evidence of m. canis tinea capitis were entered into the study and asked to return at week 2 and then every 2 weeks thereafter until cured, ... | 2001 | 11841643 |
| efficacy of itraconazole as a combined continuous/pulse therapy in feline dermatophytosis: preliminary results in nine cases. | this study evaluated the efficacy of itraconazole as a combined continuous/pulse therapy for feline dermatophytosis. nine cats with dermatophytosis caused by microsporum canis were treated with itraconazole at 10 mg kg(-1) orally once daily for 28 days and then on an alternate week regimen (1 week off, 1 week on) at the same dosage. cats were re-evaluated by physical examination and fungal culture at days 28, 42, 56 and 70 if necessary. treatment was stopped when two consecutive negative fungal ... | 2001 | 11844225 |
| pseudomycetoma caused by microsporum canis in a persian cat: lack of response to oral terbinafine. | an eight-year-old neutered female persian cat with a four-year history of relapsing skin disease, characterised by ulcerated nodules with a yellow granular discharge, was examined. a diagnosis of granulomatous dermatitis and panniculitis (pseudomycetoma) caused by microsporum canis was made on the basis of history, clinical signs, histopathological examination of skin biopsy specimens and culture of macerated tissue. because previous therapy, comprising repeated surgical excision and the adminis ... | 2001 | 11721986 |
| determination of terbinafine hydrochloride in cat hair by two chromatographic methods. | terbinafine hydrochloride (terbhcl) concentration on the site of infection with microsporum canis is a very important indicator of drug effectiveness. several chromatographic methods exist that can be used for the determination of terbhcl concentration in biological samples. a high performance liquid chromatographic (hplc) method and a gas chromatographic (gc) method have been compared and critically evaluated for the determination of a terbhcl levels in cat hair. the sensitivity and the lineari ... | 2001 | 11748682 |
| tinea capitis in adults during 1981-95 in northern greece. | the mycological laboratory of our hospital examined 31,073 patients between 1981 and 1995. sex, age, the residence of patients, the clinical type of tinea and contacts with other persons and animals were investigated. all the patients were also examined under wood's light. tinea capitis was diagnosed in 35 adults. trichophyton violaceum was the commonest aetiological agent (54.5%), especially in elderly women. the other anthropophilic fungi were t. rubrum (8.5%), t. schoenleinii (5.7%) and t. to ... | 2001 | 11766106 |