Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| cip2a promotes t-cell activation and immune response to listeria monocytogenes infection. | the oncoprotein cancerous inhibitor of protein phosphatase 2a (cip2a) is overexpressed in most malignancies and is an obvious candidate target protein for future cancer therapies. however, the physiological importance of cip2a-mediated pp2a inhibition is largely unknown. as pp2a regulates immune responses, we investigated the role of cip2a in normal immune system development and during immune response in vivo. we show that cip2a-deficient mice (cip2ahoz) present a normal immune system developmen ... | 2016 | 27100879 |
| recent advances in subunit vaccine carriers. | the lower immunogenicity of synthetic subunit antigens, compared to live attenuated vaccines, is being addressed with improved vaccine carriers. recent reports indicate that the physio-chemical properties of these carriers can be altered to achieve optimal antigen presentation, endosomal escape, particle bio-distribution, and cellular trafficking. the carriers can be modified with various antigens and ligands for dendritic cells targeting. they can also be modified with adjuvants, either covalen ... | 2016 | 27104575 |
| antihelminthics in helminth-endemic areas: effects on hiv disease progression. | helminth infections, such as soil-transmitted helminths, schistosomiasis, onchocerciasis, and lymphatic filariasis, are prevalent in many countries where human immunodeficiency virus (hiv) infection is also common. there is some evidence from observational studies that hiv and helminth co-infection may be associated with higher viral load and lower cd4+ cell counts. treatment of helminth infections with antihelminthics (deworming drugs) may have benefits for people living with hiv beyond simply ... | 2016 | 27075622 |
| examining the factor structure of the 39-item and 15-item versions of the five facet mindfulness questionnaire before and after mindfulness-based cognitive therapy for people with recurrent depression. | research into the effectiveness and mechanisms of mindfulness-based interventions (mbis) requires reliable and valid measures of mindfulness. the 39-item five facet mindfulness questionnaire (ffmq-39) is a measure of mindfulness commonly used to assess change before and after mbis. however, the stability and invariance of the ffmq factor structure have not yet been tested before and after an mbi; pre to post comparisons may not be valid if the structure changes over this period. our primary aim ... | 2016 | 27078186 |
| development of a short version of msqol-54 using factor analysis and item response theory. | the multiple sclerosis quality of life-54 (msqol-54, 52 items grouped in 12 subscales plus two single items) is the most used ms specific health related quality of life inventory. | 2016 | 27078146 |
| docosahexenoic acid treatment ameliorates cartilage degeneration via a p38 mapk-dependent mechanism. | osteoarthritis (oa) is a common chronic inflammatory disease, characterized by cartilage degradation. the aberrant expression of matrix metalloproteinase-13 (mmp-13) plays a vital role in the pathogenesis of oa. the anti‑inflammatory property of docosahexenoic acid (dha) was previously revealed and showed that dha retards the progress of many types of inflammatory disease. to evaluate the prophylactic function of dha in oa, the effect of dha on cartilage degeneration was assessed in interleukin‑ ... | 2016 | 27082436 |
| nav1.7 and other voltage-gated sodium channels as drug targets for pain relief. | chronic pain is a massive clinical problem. we discuss the potential of subtype selective sodium channel blockers that may provide analgesia with limited side effects. | 2016 | 26941184 |
| regularized structural equation modeling. | a new method is proposed that extends the use of regularization in both lasso and ridge regression to structural equation models. the method is termed regularized structural equation modeling (regsem). regsem penalizes specific parameters in structural equation models, with the goal of creating easier to understand and simpler models. although regularization has gained wide adoption in regression, very little has transferred to models with latent variables. by adding penalties to specific parame ... | 2016 | 27398019 |
| autoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosis. | dendritic cells (dcs) rendered suppressive by treatment with mitomycin c and loaded with the autoantigen myelin basic protein demonstrated earlier their ability to prevent experimental autoimmune encephalomyelitis (eae), the animal model for multiple sclerosis (ms). this provides an approach for prophylactic vaccination against autoimmune diseases. for clinical application such dcs are difficult to generate and autoantigens hold the risk of exacerbating the disease. | 2016 | 27131971 |
| binding of cfa/i pili of enterotoxigenic escherichia coli to asialo-gm1 is mediated by the minor pilin cfae. | cfa/i pili are representatives of a large family of related pili that mediate the adherence of enterotoxigenic escherichia coli to intestinal epithelial cells. they are assembled via the alternate chaperone-usher pathway and consist of two subunits, cfab, which makes up the pilus shaft and a single pilus tip-associated subunit, cfae. the current model of pilus-mediated adherence proposes that cfa/i has two distinct binding activities; the cfae subunit is responsible for binding to receptors of u ... | 2016 | 26975993 |
| epigenetic regulation of spinal cord gene expression contributes to enhanced postoperative pain and analgesic tolerance subsequent to continuous opioid exposure. | opioids have become the mainstay for treatment of moderate to severe pain and are commonly used to treat surgical pain. while opioid administration has been shown to cause opioid-induced hyperalgesia and tolerance, interactions between opioid administration and surgery with respect to these problematic adaptations have scarcely been addressed. accumulating evidence suggests opioids and nociceptive signaling may converge on epigenetic mechanisms in spinal cord to enhance or prolong neuroplastic c ... | 2016 | 27094549 |
| self-compassion scale (scs): psychometric properties of the french translation and its relations with psychological well-being, affect and depression. | over the past few years, the topic of self-compassion has attracted increasing attention from both scientific and clinical fields. the self-compassion scale (scs) was created to specifically capture this way of being kind and understanding towards oneself in moments of turmoil. in this article, we present a french adaptation of the scs. we first explore the psychometric properties of this adaptation and then investigate its relation to psychological well-being. as in the original version of the ... | 2016 | 27078886 |
| dimethyl fumarate treatment induces adaptive and innate immune modulation independent of nrf2. | dimethyl fumarate (dmf) (bg-12, tecfidera) is a fumaric acid ester (fae) that was advanced as a multiple sclerosis (ms) therapy largely for potential neuroprotection as it was recognized that faes are capable of activating the antioxidative transcription factor nuclear factor (erythroid-derived 2)-like 2 (nrf2) pathway. however, dmf treatment in randomized controlled ms trials was associated with marked reductions in relapse rate and development of active brain mri lesions, measures considered t ... | 2016 | 27078105 |
| coping with occupational stress: the role of optimism and coping flexibility. | the current study aimed at measuring whether coping flexibility is a reliable and valid construct in a uk sample and subsequently investigating the association between coping flexibility, optimism, and psychological health - measured by perceived stress and life satisfaction. a uk university undergraduate student sample (n=95) completed an online questionnaire. the study is among the first to examine the validity and reliability of the english version of a scale measuring coping flexibility in a ... | 2016 | 27186146 |
| confidence-more a personality or ability trait? it depends on how it is measured: a comparison of young and older adults. | the current study (n = 244) compared two independently developed and substantively different measures of self-confidence; a self-report measure, and a measure described as "online." online measures are confidence-accuracy judgments made following each item on a cognitive task; in the current study, online measures were yoked to tasks of fluid and crystallized intelligence. the self-report and online measures had not previously been compared, and it was unknown if they captured the same self-conf ... | 2016 | 27148126 |
| validation of the spanish version of mackey childbirth satisfaction rating scale. | the "mackey childbirth satisfaction rating scale" (mcsrs) is a complete non-validated scale which includes the most important factors associated with maternal satisfaction. our primary purpose was to describe the internal structure of the scale and validate the reliability and validity of concept of its spanish version mcsrs-e. | 2016 | 27084092 |
| azacitidine front-line in 339 patients with myelodysplastic syndromes and acute myeloid leukaemia: comparison of french-american-british and world health organization classifications. | the mds-iwg and nccn currently endorse both fab and who classifications of mds and aml, thus allowing patients with 20-30 % bone marrow blasts (aml20-30, formerly mds-raeb-t) to be categorised and treated as either mds or aml. in addition, an artificial distinction between aml20-30 and aml30+ was made by regulatory agencies by initially restricting approval of azacitidine to aml20-30. thus, uncertainty prevails regarding the diagnosis, prognosis and optimal treatment timing and strategy for pati ... | 2016 | 27084507 |
| cross-culture validation of the hiv/aids stress scale: the development of a revised chinese version. | being hiv-infected is a stressful experience for many individuals. to assess hiv-related stress in the chinese context, a measure with satisfied psychometric properties is yet underdeveloped. this study aimed to examine the psychometric characteristics of a simplified chinese version of the hiv/aids stress scale (ss-hiv) among people living with hiv/aids in central china. | 2016 | 27043134 |
| triptolide modulates trem-1 signal pathway to inhibit the inflammatory response in rheumatoid arthritis. | triptolide (tp), an active component isolated from tripterygiumwilfordii hook f, has therapeutic potential against rheumatoid arthritis (ra). however, the underlying molecular mechanism has not been fully elucidated. the aim of this study is to investigate the mechanisms of tp acting on ra by combining bioinformatics analysis with experiment validation. the human protein targets of tp and the human genes of ra were found in the pubchem database and ncbi, respectively. these two dataset were then ... | 2016 | 27049384 |
| transformation of human cd34+ hematopoietic progenitor cells with dek-nup214 induces aml in an immunocompromised mouse model. | acute myeloid leukemia (aml) is a heterogeneous disease comprising a large number of subtypes defined by specific chromosome abnormalities. one such subtype carries the t(6;9)(p22;q34) chromosome rearrangement, which leads to expression of the dek-nup214 chimeric gene, and has a particularly poor outcome. to provide a better understanding of the molecular etiology of these relatively rare individual aml variants, it is necessary to generate in vivo models, which can also serve as a means to eval ... | 2016 | 27065320 |
| resveratrol attenuates inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis neurons associated with hyperalgesia in rats. | resveratrol, a component of red wine, has been reported to decrease prostaglandin e2 production by inhibiting the cyclooxygenase-2 cascade and to modulate various voltage-dependent ion channels, suggesting that resveratrol could attenuate inflammatory hyperalgesia. however, the effects of resveratrol on inflammation-induced hyperexcitability of nociceptive neurons in vivo remain to be determined. thus, the aim of the present study was to determine whether daily systemic administration of resvera ... | 2016 | 27068286 |
| induction of autoimmune disease by deletion of ctla-4 in mice in adulthood. | cytotoxic t lymphocyte antigen-4 (ctla-4) is essential for immunological (self-) tolerance, but due to the early fatality of ctla-4 ko mice, its specific function in central and peripheral tolerance and in different systemic diseases remains to be determined. here, we further examined the role of ctla-4 by abrogating ctla-4 expression in adult mice and compared the resulting autoimmunity that follows with that produced by congenital ctla-4 deficiency. we found that conditional deletion of ctla-4 ... | 2016 | 27071130 |
| cxcr3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-th17 cytokine milieu and reducing cns-infiltrating th17 cells. | experimental autoimmune encephalomyelitis (eae) is a mouse model of multiple sclerosis (ms). it has been shown that th17 cells are critical for eae pathogenesis. mice lacking cxcr3 develop aggravated eae compared with wild-type (wt) mice. this study investigated the effect of cxcr3 on th17 expansion during eae and further addressed the underlying mechanism. | 2016 | 27068264 |
| hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity. | hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated from the mavolanate-shikimate biosynthesis pathways in plants. several simple phenolic compounds such as cinnamic acid, p-coumaric acid, ferulic acid, caffeic acid, chlorgenic acid, and rosmarinic acid belong to this class. these phenolic compounds possess potent antioxidant and anti-inflammatory properties. these compounds were also showed potential therapeutic benefit in experimental diabetes and hyperlip ... | 2016 | 27069498 |
| real-time estimation of wildfire perimeters from curated crowdsourcing. | real-time information about the spatial extents of evolving natural disasters, such as wildfire or flood perimeters, can assist both emergency responders and the general public during an emergency. however, authoritative information sources can suffer from bottlenecks and delays, while user-generated social media data usually lacks the necessary structure and trustworthiness for reliable automated processing. this paper describes and evaluates an automated technique for real-time tracking of wil ... | 2016 | 27063569 |
| characterization of seed storage proteins from chickpea using 2d electrophoresis coupled with mass spectrometry. | proteomic analysis was employed to map the seed storage protein network in landrace and cultivated chickpea accessions. protein extracts were separated by two-dimensional gel electrophoresis (2d-ge) across a broad range 3.0-10.0 immobilized ph gradient (ipg) strips. comparative elucidation of differentially expressed proteins between two diverse geographically originated chickpea accessions was carried out using 2d-ge coupled with mass spectrometry. a total of 600 protein spots were detected in ... | 2016 | 27144024 |
| adaptation and validation of the short version whoqol-hiv in ethiopia. | quality of life of patients is an important element in the evaluation of outcome of health care, social services and clinical trials. the whoqol instruments were originally developed for measurement of quality of life across cultures. however, there were concerns raised about the cross-cultural equivalence of the whoqol-hiv when used among people with hiv in ethiopia. therefore, this study aimed at adapting the whoqol-hiv bref for the ethiopian setting. | 2016 | 27064377 |
| psychometric properties of the norwegian version of the kidscreen-27 questionnaire. | the norwegian version of the kidscreen-27, a measure of generic health-related quality of life, has not yet been validated. thus, the aim of this study was to investigate the reliability and validity of the norwegian kidscreen-27, in 10 year-old children. | 2016 | 27062022 |
| developing physical frailty specifications for investigation of frailty pathways in older people. | different frailty definitions are suitable for different purposes. when investigating its key multidimensional predictors and effects, narrower definitions of frailty that exclude these elements may be more desirable. for this purpose, candidate physical frailty specifications are constructed and then evaluated on their construct and concurrent validity. for 4638 participants aged 65 to 89 years from wave 2 (2004) of the english longitudinal study of ageing, confirmatory factor analysis is perfo ... | 2016 | 27059656 |
| stability of the encoding plasmids and surface expression of cs6 differs in enterotoxigenic escherichia coli (etec) encoding different heat-stable (st) enterotoxins (sth and stp). | enterotoxigenic escherichia coli (etec), one of the most common reasons of diarrhea among infants and children in developing countries, causes disease by expression of either or both of the enterotoxins heat-labile (lt) and heat-stable (st; divided into human-type [sth] and porcine-type [stp] variants), and colonization factors (cfs) among which cs6 is one of the most prevalent etec cfs. in this study we show that etec isolates expressing cs6+sth have higher copy numbers of the cssabcd operon en ... | 2016 | 27054573 |
| a single amino acid substitution prevents recognition of a dominant human aquaporin-4 determinant in the context of hla-drb1*03:01 by a murine tcr. | aquaporin 4 (aqp4) is considered a putative autoantigen in patients with neuromyelitis optica (nmo), an autoinflammatory disorder of the central nervous system (cns). hla haplotype analyses of patients with nmo suggest a positive association with hla-drb1* 03:01. we previously showed that the human (h) aqp4 peptide 281-300 is the dominant immunogenic determinant of haqp4 in the context of hla-drb1*03:01. this immunogenic peptide stimulates a strong th1 and th17 immune response. aqp4281-300-speci ... | 2016 | 27054574 |
| synthesis and characterization of a disubstituted piperazine derivative with t-type channel blocking action and analgesic properties. | t-type calcium channels are important contributors to signaling in the primary afferent pain pathway and are thus important targets for the development of analgesics. it has been previously reported that certain piperazine-based compounds such as flunarizine are able to inhibit t-type calcium channels. thus, we hypothesized that novel piperazine compounds could potentially act as analgesics. | 2016 | 27053601 |
| inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor gfrα3. | tissue injury prompts the release of a number of proalgesic molecules that induce acute and chronic pain by sensitizing pain-sensing neurons (nociceptors) to heat and mechanical stimuli. in contrast, many proalgesics have no effect on cold sensitivity or can inhibit cold-sensitive neurons and diminish cooling-mediated pain relief (analgesia). nonetheless, cold pain (allodynia) is prevalent in many inflammatory and neuropathic pain settings, with little known of the mechanisms promoting pain vs. ... | 2016 | 27051069 |
| sialylation converts arthritogenic igg into inhibitors of collagen-induced arthritis. | rheumatoid arthritis (ra)-associated igg antibodies such as anti-citrullinated protein antibodies (acpas) have diverse glycosylation variants; however, key sugar chains modulating the arthritogenic activity of igg remain to be clarified. here, we show that reduced sialylation is a common feature of ra-associated igg in humans and in mouse models of arthritis. genetically blocking sialylation in activated b cells results in exacerbation of joint inflammation in a collagen-induced arthritis (cia) ... | 2016 | 27046227 |
| substance use and depression symptomatology: measurement invariance of the beck depression inventory (bdi-ii) among non-users and frequent-users of alcohol, nicotine and cannabis. | depression is a highly heterogeneous condition, and identifying how symptoms present in various groups may greatly increase our understanding of its etiology. importantly, major depressive disorder is strongly linked with substance use disorders, which may ameliorate or exacerbate specific depression symptoms. it is therefore quite plausible that depression may present with different symptom profiles depending on an individual's substance use status. given these observations, it is important to ... | 2016 | 27046165 |
| recent progress in endothelial progenitor cell culture systems: potential for stroke therapy. | endothelial progenitor cells (epcs) participate in endothelial repair and angiogenesis due to their abilities to differentiate into endothelial cells and to secrete protective cytokines and growth factors. consequently, there is considerable interest in cell therapy with epcs isolated from peripheral blood to treat various ischemic injuries. quality and quantity-controlled culture systems to obtain mononuclear cells enriched in epcs with well-defined angiogenic and anti-inflammatory phenotypes h ... | 2016 | 27041632 |
| hyperoside exerts anti-inflammatory and anti-arthritic effects in lps-stimulated human fibroblast-like synoviocytes in vitro and in mice with collagen-induced arthritis. | hyperoside is a flavonol glycoside mainly found in plants of the genera hypericum and crataegus, which has shown anti-oxidant, anti-cancer and anti-inflammatory activities. in this study, we investigated the effects of hyperoside on human rheumatoid fibroblast-like synoviocytes (flss) in vitro and on mouse collagen-induced arthritis (cia) in vivo. | 2016 | 27041460 |
| kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination. | multiple sclerosis (ms) is characterized by autoimmune damage to the central nervous system. all the current drugs for ms target the immune system. although effective in reducing new lesions, they have limited effects in preventing the progression of disability. promoting oligodendrocyte-mediated remyelination and recovery of neurons are the new directions of ms therapy. the endogenous opioid system, consisting of mor, dor, kor and their ligands, has been suggested to participate in the pathogen ... | 2016 | 27040771 |
| a simple and novel strategy for the production of a pan-specific antiserum against elapid snakes of asia. | snakebite envenomation is a serious medical problem in many tropical developing countries and was considered by who as a neglected tropical disease. antivenom (av), the rational and most effective treatment modality, is either unaffordable and/or unavailable in many affected countries. moreover, each av is specific to only one (monospecific) or a few (polyspecific) snake venoms. this demands that each country to prepare av against its local snake venoms, which is often not feasible. preparation ... | 2016 | 27058956 |
| validity assessment of the persian version of the nordic safety climate questionnaire (nosacq-50): a case study in a steel company. | the nordic safety climate questionnaire-50 (nosacq-50) was developed by a team of nordic occupational safety researchers based on safety climate and psychological theories. the aim of this study was to develop and validate the persian version of nosacq-50 and assess the score of safety climate on a group of workers in a steel company in iran. | 2016 | 27924236 |
| icariin exerts estrogen-like activity in ameliorating eae via mediating estrogen receptor β, modulating hpa function and glucocorticoid receptor expression. | estrogen exerts neuroprotective and anti-inflammatory effects in eae and multiple sclerosis (ms), but its clinical application is hindered due to side effects and risk of tumor. phytoestrogen structurally or functionally mimics estrogen with fewer side effects than endogenous estrogen. icariin (ica), an active component of epimedium extracts, demonstrates estrogen-like neuroprotective effects. however, it is unclear whether ica is effective in eae and what are the underlying mechanisms. | 2016 | 27186315 |
| β2-adrenoceptor signaling reduction in dendritic cells is involved in the inflammatory response in adjuvant-induced arthritic rats. | rheumatoid arthritis (ra) is characterized by inflammation of the synovium, which leads to the progressive destruction of cartilage and bone. adrenoreceptor (ar) signaling may play an important role in modulating dendritic cell (dc), which may be involved in the pathogenesis of ra. we examined the effect of the β-ar agonist isoprenaline (iso) on dc function, the impact of the β2-ar agonist salbutamol on adjuvant-induced arthritic (aa) rats, and changes in β2-ar signaling in dcs during the course ... | 2016 | 27079168 |
| psychometric evaluation of the ford insomnia response to stress test (first) in early pregnancy. | to evaluate the construct validity and factor structure of the spanish-language version of the ford insomnia response to stress test questionnaire (first-s) when used in early pregnancy. | 2016 | 26857055 |
| clec4a4 is a regulatory receptor for dendritic cells that impairs inflammation and t-cell immunity. | dendritic cells (dcs) comprise several subsets that are critically involved in the initiation and regulation of immunity. clec4a4/dc immunoreceptor 2 (dcir2) is a c-type lectin receptor (clr) exclusively expressed on cd8α(-) conventional dcs (cdcs). however, how clec4a4 controls immune responses through regulation of the function of cd8α(-) cdcs remains unclear. here we show that clec4a4 is a regulatory receptor for the activation of cd8α(-) cdcs that impairs inflammation and t-cell immunity. cl ... | 2016 | 27068492 |
| prevalence of lymphatic filariasis and treatment effectiveness of albendazole/ ivermectin in individuals with hiv co-infection in southwest-tanzania. | annual mass treatment with ivermectin and albendazole is used to treat lymphatic filariasis in many african countries, including tanzania. in areas where both diseases occur, it is unclear whether hiv co-infection reduces treatment success. | 2016 | 27070786 |
| macrophage-colony stimulating factor derived from injured primary afferent induces proliferation of spinal microglia and neuropathic pain in rats. | peripheral nerve injury induces proliferation of microglia in the spinal cord, which can contribute to neuropathic pain conditions. however, candidate molecules for proliferation of spinal microglia after injury in rats remain unclear. we focused on the colony-stimulating factors (csfs) and interleukin-34 (il-34) that are involved in the proliferation of the mononuclear phagocyte lineage. we examined the expression of mrnas for macrophage-csf (m-csf), granulocyte macrophage-csf (gm-csf), granulo ... | 2016 | 27071004 |
| highlights of the 8th international conference on vaccines for enteric diseases: the scottish encounter to defeat diarrheal diseases. | infectious diarrhea is a leading cause of morbidity and of mortality; the burden of disease affects individuals of all ages but particularly young children, especially those living in poor regions where the disease is endemic. it is also a health concern for international travelers to these areas. experts on vaccines and enteric infections and advocates for global health improvement gathered in scotland from 8 to 10 july 2015 to discuss recent advances in the assessment and understanding of the ... | 2016 | 26936100 |
| chitosan-based intranasal vaccine against escherichia coli o157:h7. | enterohemorrhagic escherichia coli (ehec) o157:h7 is an infectious zoonotic pathogen causing human infections. these infections, in some cases, can lead to hemolytic uremic syndrome and its life-threatening complications and even death worldwide. the first intimate bacterial adhesion, intimin (i), with its own receptor translocated intimin receptor (tir) and e. coli secreted protein a, acting as tir conduit, are highly immunogenic proteins for vaccine development against e. coli o157:h7. | 2016 | 26724233 |
| the autoimmunity-associated gene rgs1 affects the frequency of t follicular helper cells. | rgs1 (regulator of g-protein signaling 1) has been associated with multiple autoimmune disorders including type i diabetes. rgs1 desensitizes the chemokine receptors ccr7 and cxcr4 that are critical to the localization of t and b cells in lymphoid organs. to explore how rgs1 variation contributes to autoimmunity, we generated rgs1 knockdown (kd) mice in the nonobese diabetic (nod) model for type i diabetes. we found that rgs1 kd increased the size of germinal centers, but decreased the frequency ... | 2016 | 27029527 |
| oxygen depletion recorded in upper waters of the glacial southern ocean. | oxygen depletion in the upper ocean is commonly associated with poor ventilation and storage of respired carbon, potentially linked to atmospheric co2 levels. iodine to calcium ratios (i/ca) in recent planktonic foraminifera suggest that values less than ∼2.5 μmol mol(-1) indicate the presence of o2-depleted water. here we apply this proxy to estimate past dissolved oxygen concentrations in the near surface waters of the currently well-oxygenated southern ocean, which played a critical role in c ... | 2016 | 27029225 |
| social justice and social order: binding moralities across the political spectrum. | two studies explored the relationship between political ideology and endorsement of a range of moral principles. political liberals and conservatives did not differ on intrapersonal or interpersonal moralities, which require self-regulation. however differences emerged on collective moralities, which involve social regulation. contrary to moral foundations theory, both liberals and conservatives endorsed a group-focused binding morality, specifically social justice and social order respectively. ... | 2016 | 27031103 |
| infected groin (graft/patch): managed with sartorious muscle flap. | the purpose of this study was to review the natural history, clinical outcome and safety in patients undergoing sartorius muscle flap (smf) for groin infection, including lymphocele. | 2016 | 27051655 |
| characteristics of older adults admitted to hospital versus those discharged home, in emergency department patients referred to internal medicine. | frail older adults present to the emergency department (ed) with complex medical, functional, and social needs. when these needs can be addressed promptly, discharge is possible, and when they cannot, hospital admission is required. we evaluated the care needs of frail older adults in the ed who were consulted to internal medicine and seen by a geriatrician to determine, under current practices, which factors were associated with hospitalization and which allowed discharge. | 2016 | 27076860 |
| [18f]cfa as a clinically translatable probe for pet imaging of deoxycytidine kinase activity. | deoxycytidine kinase (dck), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dn) salvage pathway, is an important therapeutic and positron emission tomography (pet) imaging target in cancer. pet probes for dck have been developed and are effective in mice but have suboptimal specificity and sensitivity in humans. to identify a more suitable probe for clinical dck pet imaging, we compared the selectivity of two candidate compounds-[(18)f]clofarabine; 2-chloro-2'-deoxy-2'-[(18)f]fluoro ... | 2016 | 27035974 |
| classical dendritic cells are required for dietary antigen-mediated induction of peripheral t(reg) cells and tolerance. | oral tolerance prevents pathological inflammatory responses to innocuous foreign antigens by peripheral regulatory t cells (pt(reg) cells). however, whether a particular subset of antigen-presenting cells (apcs) is required during dietary antigen exposure for the 'instruction' of naive cd4(+) t cells to differentiate into pt(reg) cells has not been defined. using myeloid lineage-specific apc depletion in mice, we found that monocyte-derived apcs were dispensable, while classical dendritic cells ... | 2016 | 27019226 |
| ct angiography analysis of axillary artery diameter versus common femoral artery diameter: implications for axillary approach for transcatheter aortic valve replacement in patients with hostile aortoiliac segment and advanced lung disease. | objective. the use of the axillary artery as an access site has lost favor in percutaneous intervention due to the success of these procedures from a radial or brachial alternative. however, these distal access points are unable to safely accommodate anything larger than a 7-french sheath. to date no studies exist describing the size of the axillary artery in relation to the common femoral artery in a patient population. we hypothesized that the axillary artery is of comparable size to the cfa i ... | 2016 | 27110403 |
| validation of a german version of the ethical leadership at work questionnaire by kalshoven et al. (2011). | the present study evaluates the psychometric properties of a german version of the ethical leadership at work questionnaire (elw-d), and further embeds the construct of ethical leadership within its nomological network. confirmatory factor analyses (cfas) based on the total sample of n = 363 employees support the assumed seven-factor structure of the german translation. within a sub-sample of n = 133, the elw-d shows positive correlations with related leadership behaviors (transformational leade ... | 2016 | 27065916 |
| validation of a spanish translation of the gratitude questionnaire (gq-6) with a chilean sample of adults and high schoolers. | recent studies have associated positive emotions with several variables such as learning, coping strategies or assertive behaviour. the concept of gratitude has been specifically defined as a tendency to recognise and respond to people or situations with grateful emotion. unfortunately in latin america, no validated measures of gratitude on different populations are available. the aim of this study was to analyse the psychometric properties of the gratitude questionnaire (gq-6) in two chilean sa ... | 2016 | 27036956 |
| social networking site use while driving: adhd and the mediating roles of stress, self-esteem and craving. | adults who present adhd symptoms have an increased risk for vehicle accidents. one conceivable overlooked account for this association is the possibility that people with adhd symptoms use rewarding technologies such as social networking sites (sns) while driving, more than others. the objective of this study was to understand if and how adhd symptoms can promote sns use while driving and specifically to conceptualize and examine mechanisms which may underlie this association. to do so, adhd is ... | 2016 | 27065923 |
| the dirty dozen scale: validation of a polish version and extension of the nomological net. | in five studies (total n = 1300) we developed and validated a polish version of the dirty dozen measure (dtdd-p) that measures the three traits of the dark triad, machiavellianism, psychopathy, and narcissism. we detail the presence and stability of a bifactor structure of the 12 items and present evidence for good internal consistency and test-retest reliability. we examine the nomological network surrounding the dark triad and show that both the dark triad total score and the subscales have ac ... | 2016 | 27065915 |
| stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human p2x3 receptors and inflammatory pain. | a growing body of evidence suggests that atp-gated p2x3 receptors (p2x3rs) are implicated in chronic pain. we address the possibility that stable, synthetic analogs of diadenosine tetraphosphate (ap4a) might induce antinociceptive effects by inhibiting p2x3rs in peripheral sensory neurons. | 2016 | 27030723 |
| myelin-reactive antibodies initiate t cell-mediated cns autoimmune disease by opsonization of endogenous antigen. | in the pathogenesis of central nervous system (cns) demyelinating disorders, antigen-specific b cells are implicated to act as potent antigen-presenting cells (apc), eliciting waves of inflammatory cns infiltration. here, we provide the first evidence that cns-reactive antibodies (ab) are similarly capable of initiating an encephalitogenic immune response by targeting endogenous cns antigen to otherwise inert myeloid apc. in a transgenic mouse model, constitutive production of ab against myelin ... | 2016 | 27022743 |
| generation of recombinant monoclonal antibodies from immunised mice and rabbits via flow cytometry and sorting of antigen-specific igg+ memory b cells. | single b cell screening strategies, which avoid both hybridoma fusion and combinatorial display, have emerged as important technologies for efficiently sampling the natural antibody repertoire of immunized animals and humans. having access to a range of methods to interrogate different b cell subsets provides an attractive option to ensure large and diverse panels of high quality antibody are produced. the generation of multiple antibodies and having the ability to find rare b cell clones produc ... | 2016 | 27022949 |
| long-term effects of (-)-epigallocatechin gallate (egcg) on pristane-induced arthritis (pia) in female dark agouti rats. | rheumatoid arthritis (ra)--a widespread chronic inflammatory disease in industrialized countries--is characterized by a persistent and progressive joint destruction. the chronic pro-inflammatory state results from a mutual activation of the innate and the adaptive immune system, while the exact pathogenesis mechanism is still under discussion. new data suggest a role of the innate immune system and especially polymorphonuclear granulocytes (pmns, neutrophils) not only during onset and the destru ... | 2016 | 27023113 |
| controversies regarding the psychometric properties of the brief cope: the case of the brazilian-portuguese version "cope breve". | the brief coping orientation to problems experienced (cope) inventory investigates the different ways in which people respond to stressful situations. knowledge is lacking regarding the coping strategies and styles of people in developing countries, including brazil. this study aimed to adapt and validate the brief cope to brazilian portuguese (named cope breve) by focusing on dispositional coping. for the cross-cultural adaptation, the original brief cope in english (28 items grouped into 14 su ... | 2016 | 27007646 |
| sex-specific neural circuits of emotion regulation in the centromedial amygdala. | sex-related differences in emotion regulation (er) in the frequency power distribution within the human amygdala, a brain region involved in emotion processing, have been reported. however, how sex differences in er are manifested in the brain networks which are seeded on the amygdala subregions is unclear. the goal of this study was to investigate this issue from a brain network perspective. utilizing resting-state functional connectivity (rsfc) analysis, we found that the sex-specific function ... | 2016 | 27004933 |
| complement receptor 3 mediates renal protection in experimental c3 glomerulopathy. | c3 glomerulopathy is a complement-mediated renal disease that is frequently associated with abnormalities in regulation of the complement alternative pathway. mice with deficiency of factor h (cfh(-/-)), a negative alternative pathway regulator, are an established experimental model of c3 glomerulopathy in which complement c3 fragments including ic3b accumulate along the glomerular basement membrane. here we show that deficiency of complement receptor 3 (cr3), the main receptor for ic3b, enhance ... | 2016 | 26924054 |
| factor structure of the positive and negative affect schedule (panas) in adult women with fibromyalgia from southern spain: the al-ándalus project. | fibromyalgia is a syndrome characterized by the presence of widespread chronic pain. people with fibromyalgia report lower levels of positive affect and higher levels of negative affect than non-fibromyalgia peers. the positive and negative affect schedule (panas)-a widely used questionnaire to assess two core domains of affect; namely 'positive affect' and 'negative affect' -has a controversial factor structure varying across studies. the internal structure of a measurement instrument has an im ... | 2016 | 27047704 |
| rorγt+ cells selectively express redundant cation channels linked to the golgi apparatus. | retinoid-related orphan receptor gamma t (rorγt) is a master transcription factor central to type 17 immunity involving cells such as t helper 17, group 3 innate lymphoid cells or il-17-producing γδ t cells. here we show that the intracellular ion channel tmem176b and its homologue tmem176a are strongly expressed in these rorγt(+) cells. we demonstrate that tmem176a and b exhibit a similar cation channel activity and mainly colocalise in close proximity to the trans-golgi network. strikingly, in ... | 2016 | 27009467 |
| diagnosing depression in chronic pain patients: dsm-iv major depressive disorder vs. beck depression inventory (bdi). | diagnosing depression in chronic pain is challenging due to overlapping somatic symptoms. in questionnaires, such as the beck depression inventory (bdi), responses may be influenced more by pain than by the severity of depression. in addition, previous studies have suggested that symptoms of negative self-image, a key element in depression, are uncommon in chronic pain-related depression. the object of this study is to assess the relationship of the somatic and cognitive-emotional items of bdi w ... | 2016 | 27008161 |
| flagellar cap protein flid mediates adherence of atypical enteropathogenic escherichia coli to enterocyte microvilli. | the expression of flagella correlates with different aspects of bacterial pathogenicity, ranging from adherence to host cells to activation of inflammatory responses by the innate immune system. in the present study, we investigated the role of flagella in the adherence of an atypical enteropathogenic escherichia coli (aepec) strain (serotype o51:h40) to human enterocytes. accordingly, isogenic mutants deficient in flagellin (flic), the flagellar structural subunit; the flagellar cap protein (fl ... | 2016 | 26831466 |
| depletion of regulatory t cells leads to an exacerbation of delayed-type hypersensitivity arthritis in c57bl/6 mice that can be counteracted by il-17 blockade. | rodent models of arthritis have been extensively used in the elucidation of rheumatoid arthritis (ra) pathogenesis and are instrumental in the development of therapeutic strategies. here we utilise delayed-type hypersensitivity arthritis (dtha), a model in c57bl/6 mice affecting one paw with synchronised onset, 100% penetrance and low variation. we investigate the role of regulatory t cells (tregs) in dtha through selective depletion of tregsand the role of il-17 in connection with tregdepletion ... | 2016 | 26822477 |
| structure and relationships of university instructors' achievement goals. | the present study examines the achievement goals of university instructors, particularly the structure of such goals, and their relationship to biographic characteristics, other aspects of instructors' motivation, and teaching quality. two hundred and fifty-one university instructors (184 without ph.d., 97 with ph.d., thereof 51 full professors; 146 males, 92 females) answered a questionnaire measuring achievement goals, self-efficacy, and enthusiasm in altogether 392 courses. teaching quality w ... | 2016 | 27047411 |
| il-10 modulates th17 pathogenicity during autoimmune diseases. | the immune system is essential for host defense against pathogen infections; however dysregulated immune response may lead to inflammatory or autoimmune diseases. elevated activation of both innate immune cells and t cells such as th17 cells are linked to many autoimmune diseases, including multiple sclerosis (ms), arthritis and inflammatory bowel disease (ibd). to keep immune homeostasis, the immune system develops a number of negative feedback mechanisms, such as the production of anti-inflamm ... | 2016 | 27308096 |
| interleukin-1β induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes. | arthritis is a process of chronic inflammation that results in joint damage. il (interleukin)-1β is an inflammatory cytokine that acts as a key mediator of cartilage degradation, and is abundantly expressed in arthritis. neovascularization is one of the pathological characteristics of arthritis. however, the role of il-1β in the angiogenesis of chondrocytes remains unknown. in the present study, we demonstrate that stimulating chondrocytes (atdc5) with il-1β increased the expression of fgf (fibr ... | 2016 | 26811540 |
| ongoing oxidative stress causes subclinical neuronal dysfunction in the recovery phase of eae. | most multiple sclerosis (ms) patients develop over time a secondary progressive disease course, characterized histologically by axonal loss and atrophy. in early phases of the disease, focal inflammatory demyelination leads to functional impairment, but the mechanism of chronic progression in ms is still under debate. reactive oxygen species generated by invading and resident central nervous system (cns) macrophages have been implicated in mediating demyelination and axonal damage, but demyelina ... | 2016 | 27014271 |
| does subjective rating reflect behavioural coding? personality in 2 month-old dog puppies: an open-field test and adjective-based questionnaire. | a number of studies have recently investigated personality traits in non-human species, with the dog gaining popularity as a subject species for research in this area. recent research has shown the consistency of personality traits across both context and time for adult dogs, both when using questionnaire based methods of investigation and behavioural analyses of the dogs' behaviour. however, only a few studies have assessed the correspondence between these two methods, with results varying cons ... | 2016 | 26977588 |
| increased serum level of cyclopropaneoctanoic acid 2-hexyl in patients with hypertriglyceridemia-related disorders. | we recently reported the presence of various cyclopropane fatty acids-among them, cyclopropaneoctanoic acid 2-hexyl-in the adipose tissue of obese women. the aim of this study was to verify whether the presence of cyclopropaneoctanoic acid 2-hexyl in human serum was associated with obesity or chronic kidney disease (both being related to dyslipidemia), and to find potential associations between the serum level of this compound and specific markers of the these conditions. the serum concentration ... | 2016 | 27003900 |
| psychometric properties of the greek tci-r and its clinical correlates: schizotypy and the self-regulation of affective and cognitive functioning. | background. the revised temperament and character inventory (tci-r) measures cloninger's psychobiological model of personality. the average effects of individual temperament and character traits have been associated with schizotypy and with impaired regulation of affect and cognition. we extended prior research by testing predictions about the association of specific multidimensional configurations of temperament and character traits on schizotypy, affect balance, and self-perceived cognitive fu ... | 2016 | 27019787 |
| estrogen-mediated downregulation of aire influences sexual dimorphism in autoimmune diseases. | autoimmune diseases affect 5% to 8% of the population, and females are more susceptible to these diseases than males. here, we analyzed human thymic transcriptome and revealed sex-associated differences in the expression of tissue-specific antigens that are controlled by the autoimmune regulator (aire), a key factor in central tolerance. we hypothesized that the level of aire is linked to sexual dimorphism susceptibility to autoimmune diseases. in human and mouse thymus, females expressed less a ... | 2016 | 26999605 |
| concurrent validity of self-rating scale of self-directed learning and self-directed learning instrument among italian nursing students. | self-directed learning develops when students take the initiative for their learning, recognising needs, formulating goals, identifying resources, implementing appropriate strategies and evaluating learning outcomes. this should be seen as a collaborative process between the nurse educator and the learner. at the international level, various instruments have been used to measure self-directed learning abilities (sdl), both in original and in culturally-adapted versions. however, few instruments ... | 2016 | 27006641 |
| schistosoma japonicum hsp60-derived peptide sjmhe1 suppresses delayed-type hypersensitivity in a murine model. | parasite-derived molecules with immunomodulatory properties, which have been optimised during host-parasite co-evolution, exhibit potential applications as novel immunotherapeutics. we have previously demonstrated that schistosoma japonicum hsp60-derived peptide sjmhe1 induces cd4(+)cd25(+) regulatory t-cells (tregs) and that adoptively transferred sjmhe1-induced cd4(+)cd25(+) tregs inhibit delayed-type hypersensitivity (dth) in mice. however, multiple concerns regarding this method render this ... | 2016 | 26971312 |
| designing iranian model to assess the level of health system responsiveness. | given the rapid pace of changes in community health needs and the mission of healthcare organizations to provide and promote the community's health, the growing need to increase health system responsiveness to people as a key element of observance and fulfillment of justice is felt more than ever. | 2016 | 27247795 |
| validation data of a rabbit antiserum and affinity purified polyclonal antibody against the n-terminus of human gpr30. | rabbit antiserum was generated against the n-terminus of human gpr30 followed by peptide affinity purification. in this article, the methodology used and validation data are presented. the peptide affinity purified polyclonal antibody specifically detects human gpr30 in elisa and on western blots of total protein prepared from human breast cancer cell lines. | 2016 | 27408914 |
| myeloid deletion of sirt1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation. | the type iii histone deacetylase silent information regulator 1 (sirt1) is an enzyme that is critical for the modulation of immune and inflammatory responses. however, the data on its role in rheumatoid arthritis (ra) are limited and controversial. to better understand how sirt1 regulates adaptive immune responses in ra, we evaluated collagen-induced arthritis (cia) in myeloid cell-specific sirt1 knockout (msirt1 ko) and wild-type (wt) mice. arthritis severity was gauged on the basis of clinical ... | 2016 | 26987484 |
| immune complexes indirectly suppress the generation of th17 responses in vivo. | the precise context in which the innate immune system is activated plays a pivotal role in the subsequent instruction of cd4+ t helper (th) cell responses. th1 responses are downregulated when antigen is encountered in the presence of antigen-igg immune complexes. to assess if th17 responses to antigen are subject to similar influences in the presence of immune complexes we utilized an inflammatory airway disease model in which immunization of mice with complete freund's adjuvant (cfa) and ovalb ... | 2016 | 26978520 |
| mechanosensory and atp release deficits following keratin14-cre-mediated trpa1 deletion despite absence of trpa1 in murine keratinocytes. | keratinocytes are the first cells that come into direct contact with external tactile stimuli; however, their role in touch transduction in vivo is not clear. the ion channel transient receptor potential ankyrin 1 (trpa1) is essential for some mechanically-gated currents in sensory neurons, amplifies mechanical responses after inflammation, and has been reported to be expressed in human and mouse skin. other reports have not detected trpa1 mrna transcripts in human or mouse epidermis. therefore, ... | 2016 | 26978657 |
| immunogenicity of a chimeric plasmodium falciparum merozoite surface protein vaccine in aotus monkeys. | the production of properly folded, recombinant sub-unit plasmodium falciparum malaria vaccine candidates in sufficient quantities is often a challenge. success in vaccine immunogenicity studies in small animal models does not always predict immunogenicity in non-human primates and/or human subjects. the aim of this study was to assess the immunogenicity of a chimeric blood-stage malaria vaccine in aotus monkeys. this vaccine candidate includes the neutralizing b cell epitopes of p. falciparum me ... | 2016 | 26975721 |
| the annexin a2 promotes development in arthritis through neovascularization by amplification hedgehog pathway. | the neovascularization network of pannus formation plays a crucial role in the development of rheumatoid arthritis (ra). annexin a2 (axna2) is an important mediating agent that induces angiogenesis in vascular diseases. the correlation between axna2 and pannus formation has not been studied. here, we provided evidence that compared to osteoarthritis (oa) patients and healthy people, the expression of axna2 and axna2 receptor (axna2r) were up-regulated in patients with ra. joint swelling, inflamm ... | 2016 | 26963384 |
| retirement as meaningful: positive retirement stereotypes associated with longevity. | studies examining the association between retirement and health have produced mixed results. this may be due to previous studies treating retirement as merely a change in job status rather than a transition associated with stereotypes or societal beliefs (e.g., retirement is a time of mental decline or retirement is a time of growth). to examine whether these stereotypes are associated with health, we studied retirement stereotypes and survival over a 23-year period among 1,011 older adults. as ... | 2016 | 27346893 |
| psychometric evaluation of the sinhalese version of macnew heart disease health related quality of life questionnaire in patients with stable angina. | a sinhalese version of a validated, disease-specific patient-reported heart disease health related quality of life instrument is lacking. the purpose of this study was to validate the interviewer-administered sinhalese version of the macnew heart disease health-related quality of life questionnaire (macnew) in patients with clinically diagnosed stable angina. | 2016 | 26980077 |
| item response theory analysis of centers for disease control and prevention health-related quality of life (cdc hrqol) items in adults with arthritis. | examine the feasibility of performing an item response theory (irt) analysis on two of the centers for disease control and prevention health-related quality of life (cdc hrqol) modules - the 4-item healthy days core module (hdcm) and the 5-item healthy days symptoms module (hdsm). previous principal components analyses confirm that the two scales both assess a mix of mental (cdc-mh) and physical health (cdc-ph). the purpose is to conduct item response theory (irt) analysis on the cdc-mh and cdc- ... | 2016 | 26969513 |
| "there is no free here, you have to pay": actual and perceived costs as barriers to intermittent preventive treatment of malaria in pregnancy in mali. | "there is no free here," the words of a malian husband, illustrate how perceptions of cost can deter uptake of intermittent preventive treatment of malaria in pregnancy (iptp). the malian ministry of health (moh) recommends a minimum of three doses of iptp at monthly intervals. however, despite a national policy that iptp be provided free of charge, only 35% of pregnant women receive at least one dose and less than 20% receive two or more doses. | 2016 | 26968167 |
| involvement of nipsnap1, a neuropeptide nocistatin-interacting protein, in inflammatory pain. | chronic pain associated with inflammation is an important clinical problem, and the underlying mechanisms remain poorly understood. 4-nitrophenylphosphatase domain and nonneuronal snap25-like protein homolog (nipsnap) 1, an interacting protein with neuropeptide nocistatin, is implicated in the inhibition of tactile pain allodynia. although nocistatin inhibits some inflammatory pain responses, whether nipsnap1 affects inflammatory pain appears to be unclear. here, we examined the nociceptive beha ... | 2016 | 27030720 |
| spinal glutamate transporters are involved in the development of electroacupuncture tolerance. | electroacupuncture (ea) tolerance is a gradual decline in ea antinociception because of its repeated or prolonged use. this study aims to explore the role of spinal glutamate transporters (gts) in ea tolerance (eat). | 2016 | 26978348 |
| correction of severe columella and tip retraction in silicone implanted asian short noses. | silicone implants and other alloplastic materials are frequently used in rhinoplasty to augment asian short noses. however, nasal deformities as a result of implant-related infections are increasing in incidence. the resulting tissue scarrings hinder the application of traditional techniques of lengthening short noses. the following paper presents a technique to correct severe postoperative retractions of the tip and columella caused by silicone implants. | 2016 | 26965308 |
| confirmatory and exploratory factor analysis for validating the phlegm pattern questionnaire for healthy subjects. | background. phlegm pattern questionnaire (ppq) was developed to evaluate and diagnose phlegm pattern in korean medicine and traditional chinese medicine, but it was based on a dataset from patients who visited the hospital to consult with a clinician regarding their health without any strict exclusion or inclusion. in this study, we reinvestigated the construct validity of ppq with a new dataset and confirmed the feasibility of applying it to a healthy population. methods. 286 healthy subjects w ... | 2016 | 27051447 |
| human embryonic stem cell-derived mesenchymal stromal cells ameliorate collagen-induced arthritis by inducing host-derived indoleamine 2,3 dioxygenase. | the immunosuppressive and anti-inflammatory properties of mesenchymal stromal cells (msc) have prompted their therapeutic application in several autoimmune diseases, including rheumatoid arthritis. adult msc are finite and their clinical use is restricted by the need for long-term expansion protocols that can lead to genomic instability. inhibition of smad2/3 signaling in human pluripotent stem cells (hpsc) provides an infinite source of msc that match the phenotype and functional properties of ... | 2016 | 27036118 |
| measuring psychological capital: construction and validation of the compound psycap scale (cpc-12). | with the psychological capital questionnaire (pcq) being the standard measure to assess psychological capital (psycap) in the context of organizations, this paper aims to broaden this domain-specific approach by introducing a measure with universal claim. two studies were conducted to create and validate a german self-report scale (cpc-12) measuring psycap. we performed confirmatory factor analyses and correlations with other positive psychological constructs on the data of two german samples (n ... | 2016 | 27035437 |
| validation of the flourishing scale in a sample of people with suboptimal levels of mental well-being. | there is growing interest in measuring the eudaimonic perspective of mental well-being (social and psychological well-being) alongside existing measures of the hedonic perspective of mental well-being (subjective well-being). the flourishing scale (fs) assesses core aspects of social-psychological functioning and is now widely used in research in practice. however, the reliability and validity of eudaimonic measures such as the fs has not yet been tested in people with low or moderate levels of ... | 2016 | 26988345 |