Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [chagas disease in argentina: tools for schoolchildren to exercise vector surveillance and identify household risk factors]. | the objective of this paper was to validate tools for schoolchildren to help control chagas disease vectors in their own homes. two types of tables were produced, one reporting on the presence of risk factors in residences and the other to record the presence of triatomines. the materials were tested in the field by 100 students from an endemic area in argentina and validated by technical personnel. the results obtained by students concerning the percentage of households with risk factors and ve ... | 2016 | 15905931 |
| [assessment of diastolic function in chagas' disease with pulsed doppler tissue imaging]. | diastolic function is involved early during the undetermined form of chagas' disease (ch). pulsed doppler tissue imaging (dti) is a new technique to evaluate diastolic function recording myocardial velocities in the longitudinal axis. to evaluate the relevance of dti in patients with ch, we studied, with doppler and echocardiography, 49 patients (average age 49 +/- 12 years) and 20 normal subjects (average age 45 +/- 15 years) as a control group (c). patients were divided in four groups accordin ... | 2016 | 15125264 |
| [manometric and radiologic aspects of chagas' megaesophagus: the importance to its surgical treatment]. | this study analyzed the radiologic and manometric findings of 43 patients suffering from chagasic megaesophagus with positive tests for chagas' disease. there was a significant reduction in the high pressure levels of the body of the esophagus related to the stage of the disease: stage i/ii--42.9 mmhg; stage iii--23.6 mmhg; stage iv--15.6 mmhg. it was observed that 5 (35.7%) stage iii patients had high pressure levels below 20 mmhg and presented advanced megaesophagus and these underwent a subto ... | 2016 | 15049104 |
| [health education for triatomine control in an area under epidemiological surveillance in paraná state, brazil]. | this paper describes a health education project targeting a rural community and health professionals from counties undergoing epidemiological surveillance for chagas disease vectors in the state of paraná, brazil. a group of technicians from the brazilian national health foundation (funasa) was trained, together with teachers, workers, and students from the state university of maringá, who prepared an instructions manual and drew up guidelines for reporting presence of triatomines or suspected c ... | 2016 | 12488880 |
| [hypocontraction of the esophagus in patients with chagas' disease and with primary achalasia]. | the esophageal contraction amplitude is low in patients with chagas' disease and patients with primary achalasia but not every swallow is followed by low contraction amplitude. we evaluated the number of low contraction amplitude in 40 normal volunteers, 99 chagas' disease patients and 14 patients with primary achalasia. each subject performed 10 swallows of a 5 ml bolus of water and the esophageal motility was measured at 5, 10 and 15 cm above the lower esophageal sphincter by the manometric me ... | 2016 | 10962626 |
| [chagas disease in the context of sports activities: recommendations]. | 2016 | 10881142 | |
| [regression of acute chagas cardiopathy in an infant with a suspected transfusion infection]. | chagas disease was described in mexico by mazzotti in 1940. post-transfusional cases have not been described. we report proved case of acute chagasic cardiopathy in a nine months old infant with suspected transfusional infection during neonatal period. she was treated with nifurtimox with disappearance of parasites and regression of cardiopathy. she is asymptomatic nine years afterwards with normal growth and negative parasitology and serology. | 2016 | 10553194 |
| partial left ventriculectomy in patients with dialated failing ventricle. | while partial left ventriculectomy (plv) improves left ventricular energetic efficiency, concomitant reduction in mitral regurgitation may improve ventricular function. | 2016 | 10440648 |
| [cholelithiasis in chronic chageas' disease patients]. | the studies on the occurrence of biliary lithiasis in patients with chronic chagas' disease have shown conflicting results. aiming at contributing to a better understanding of the topic was assessed, by ultrasonographic scan, the frequency of colelithiasis in chagasic patients with different anatomo-clinical forms of the disease. a total of 128 patients were studied, 85 males (mean age: 53 +/- 13 years) and 43 females (mean age: 53 +/_ 10 years) nineteen males and 18 females had the cardiac form ... | 2016 | 9629316 |
| chagas disease. interruption of transmission. | 2016 | 9448479 | |
| management of heart failure. iv. anticoagulation for patients with heart failure due to left ventricular systolic dysfunction. | this article reviews the incidence of arterial thromboembolism in patients with heart failure who are not receiving anticoagulants. we also examine whether more severe ventricular dysfunction increases this incidence and the efficacy and risks of anticoagulation for patients in sinus rhythm. | 2016 | 7966873 |
| [longitudinal radiologic study of the esophagus, in an endemic area of chagas disease, in a period of 13 years]. | a radiological study of the oesophagus of a cohort of patients was carried during a 13 year period in the municipality of mambaí goiás. barium swallow findings were recorded on 70mm film using a portable machine. of 731 patients examined 382 (52.3%) were seropositive for t. cruzi. the sexes were equally divided. the incidence of detectable megaoesophagus was 7.9% among the cohort and 14.2% in the seropositive individuals. progression of the disease was noted during this longitudinal study in 21. ... | 2016 | 7855365 |
| achalasia occurring years after acute poliomyelitis. | we present a case of a 19 year old female patient with dysphagia for 4 months. radiologic, endoscopy and manometric examinations were compatible with the diagnosis of idiopathic achalasia. clinical, epidemiologic and serologic investigation was negative for chagas' disease. when she was three years old she had acute poliomyelitis that left muscular atrophy in her left leg. it is possible that lower esophageal sphincter achalasia was the consequence of lesion in the dorsal motor nucleus of the va ... | 2016 | 8147735 |
| [a longitudinal radiologic study of the esophagus in an endemic area of chagas' disease over a 6-year period]. | a longitudinal study over six years was undertaken of 494 residents of the municipality of mambaí, goiás. two hundred and twelve (43%) were seropositive in 1975/76 and 199 of 464 of the same patients group, positive in 1980/82 (42.8%). at both examination single radiographs of the oesophagus were obtained immediately after ingestion of 75 ml of barium sulphate solution and a second x-ray taken one minute later. among the 201 seropositive patients without megaesophagus in the first study 4 (2%) e ... | 2016 | 1340535 |
| [clinical therapeutic trial of 5-nitro-2-furaldehyde-semicarbazone (nitrofurazone) in the chronic form of chagas' disease]. | 2016 | 14146399 | |
| [trypanosomicidal activity of 5-nitro-2-furaldehyde-2-(2-hydroxyethyl)-semicarbazone (furadroxil) in experimental chagas' disease]. | 2016 | 14110097 | |
| [results obtained with 50% hemolysis complement fixation reaction in the diagnosis of chagas' disease]. | 2016 | 13662338 | |
| [importance of complement fixation in the diagnosis of chagas' disease; new technic employed in the cosme argerich central military hospital]. | 2016 | 13225155 | |
| [a new case of acute chagas' disease]. | 2016 | 13140425 | |
| [chemotherapy of experimental chagas' disease. xii. effects of puromycin alone and with primaquine]. | 2016 | 13140423 | |
| [acute form of chagas' disease in an adult]. | 2016 | 13105740 | |
| [trials of chemotherapy in experimental chagas disease. xi. action of isopentaquine diphosphate, alone and with quinine sulfate]. | 2016 | 13105739 | |
| [studies on chemotherapy of experimental chagas disease; isonicotinic acid hydrazide]. | 2016 | 13018376 | |
| [aggravating effect of cortisone acetate and of aureomycin in experimental chagas' disease]. | 2016 | 13018374 | |
| [trials of chemotherapy in experimental chagas' disease. ix. fumagillin]. | 2016 | 12977852 | |
| [fatal case of acute chagas' disease in an infant]. | 2016 | 12977848 | |
| [chagas' disease in children]. | 2016 | 14925173 | |
| [trial chemotherapy of experimental chagas' disease; cortisone and pentaquine phosphate]. | 2016 | 14858454 | |
| [trial chemotherapy of experimental chagas' disease; synergic action of quinine with pentaquine phosphate]. | 2016 | 14858453 | |
| [acute form of chagas' disease with classic manifestations]. | 2016 | 14821017 | |
| [attempts of chemotherapy in experimental chagas' disease. v. terramycin]. | 2016 | 14821013 | |
| [attempts at the chemotherapy of experimental chagas' disease. viii. effect of cortisone alone and associated with pentaquine phosphate or with the combination of quinine sulfate and pentaquine phosphate; histopathological study]. | 2016 | 14915993 | |
| length and caliber of the rectosigmoid colon among patients with chagas disease and controls from areas at different altitudes. | in this study, we investigated radiological changes in the sigmoid colon in chagasic patients by comparing their colon lengths and caliber with those of non-chagasic living in the same region and non-chagasic living at high altitudes. | 2016 | 24474017 |
| [health professionals' knowledge on chagas disease in the province of almeria, spain]. | health professionals who care for patients with imported diseases often lack enough training. the aim of the study is to assess the knowledge of chagas disease among doctors and nurses attending at-risk pregnant women in our province. | 2016 | 23892678 |
| current epidemiological profile of chagasic megaesophagus in central brazil. | chagasic megaesophagus (cm) is the most common digestive manifestation of chagas disease in brazil, and the state of goiás is one of the most affected regions. in recent decades, the hospital das clínicas (hc)/universidade federal de goiás (ufg) has been a reference center for the study and treatment of cm. the objective of this study was to characterize the current epidemiological profile of patients with cm observed at the hc of the ufg from 1998 to 2010. | 2016 | 23856859 |
| comparison of idiopathic achalasia and chagas' disease esophagopathy at the light of high-resolution manometry. | the comparison between idiopathic achalasia (ia) and chagas' disease esophagopathy (cde) may evaluate if treatment options and their outcomes can be accepted universally. this study aims to compare ia and cde at the light of high-resolution manometry. we studied 86 patients with achalasia: 45 patients with cde (54% females, mean age 55 years) and 41 patients with ia (58% females, mean age 49 years). all patients underwent high-resolution manometry. upper esophageal sphincter parameters were simi ... | 2016 | 23795824 |
| bradyarrhythmias and pacemaker therapy in dogs with chagas disease. | chagas disease (trypanosomiasis) is a cause of myocarditis in the southern united states causing cardiac conduction abnormalities, arrhythmias, and heart failure. | 2016 | 23662590 |
| [imported parasitic diseases in the immigrant population in spain]. | migration has contributed to the emergence of certain infectious diseases in host countries. in spain the number of immigrants has increased exponentially in recent decades. the aim of this review is to identify and analyze the available information on imported parasitic diseases in immigrant population in our country. | 2016 | 25418568 |
| silencing the odorant receptor co-receptor rproorco affects the physiology and behavior of the chagas disease vector rhodnius prolixus. | olfaction is one of the main sensory modalities that allow insects to interpret their environment. several proteins, including odorant-binding proteins (obps) and odorant receptors (ors), are involved in this process. odorant receptors are ion channels formed by a binding unit or and an odorant receptor co-receptor (orco). the main goal of this study was to characterize the orco gene of rhodnius prolixus (rproorco) and to infer its biological functions using gene silencing. the full-length rproo ... | 2016 | 25747010 |
| chitin is a component of the rhodnius prolixus midgut. | chitin is an essential component of the peritrophic matrix (pm), which is a structure that lines the insect's gut and protects against mechanical damage and pathogens. rhodnius prolixus (hemiptera: reduviidae) does not have a pm, but it has an analogous structure, the perimicrovillar membrane (pmm); chitin has not been described in this structure. here, we show that chitin is present in the r. prolixus midgut using several techniques. the ftir spectrum of the koh-resistant putative chitin-materi ... | 2016 | 25910679 |
| putting chagas disease on the us radar screen. | 2016 | 25803331 | |
| on the intersections of basic and applied research in xenotransplantation. | i am very grateful to the council and members of the international xenotransplantation association for this honorary membership. in accepting this prestigious award, i pay tribute to my mentors antonio oriol i anguera, carlos martinez, robert a. good, and hans müller-eberhard for their guidance and friendship as i was beginning my travels in biomedical research. i also thank the many gifted collaborators, students, and technical personnel, as well as the agencies and taxpayers, who funded our re ... | 2016 | 22702465 |
| [association between left ventricular wall motion abnormalities and ventricular arrhythmia in the indeterminate form of chagas disease]. | chagas' disease can lead to severe and potentially lethal damage of cardiac function. thus, the identification of cardiac abnormalities in patients presenting the indeterminate form (if) can be important for risk stratification. this paper aimed to demonstrate whether if chagasic patients who presented wall motion abnormalities showed functional and electric disturbances compared to patients with normal echocardiogram and doppler studies. | 2016 | 21503552 |
| [clinical and radiological evaluation of the esophagus and colon in the acute phase of chagas disease with report of three cases of spontaneous remission of esophageal group i aperistalsis]. | the esophagus and colons of patients with acute chagas disease were studied. | 2016 | 21340412 |
| [radiological study on megacolon cases in an endemic area for chagas disease]. | a radiological study on the colon of patients from an endemic chagas disease zone was conducted using the simplified opaque enema technique of ximenes et al. | 2016 | 21085870 |
| acute chagas disease and risk of congenital infection. | 2016 | 26420798 | |
| adipokinetic hormone receptor gene identification and its role in triacylglycerol metabolism in the blood-sucking insect rhodnius prolixus. | adipokinetic hormone (akh) has been associated with the control of energy metabolism in a large number of arthropod species due to its role on the stimulation of lipid, carbohydrate and amino acid mobilization/release. in the insect rhodnius prolixus, a vector of chagas' disease, triacylglycerol (tag) stores must be mobilized to sustain the metabolic requirements during moments of exercise or starvation. besides the recent identification of the r. prolixus akh peptide, other components required ... | 2016 | 26163435 |
| epicardial ablation of ventricular tachycardia. | epicardial mapping and ablation via a percutaneous subxiphoid technique has been instrumental in improving the working understanding of complex myocardial scars in various arrhythmogenic substrates. endocardial ablation alone may not be sufficient in patients with ischemic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, hypertrophic cardiomyopathy, and chagas disease to prevent recurrent ventricular tachycardia. multiple observational studies have demonst ... | 2016 | 26306131 |
| the prevalence of atrial fibrillation and conduction abnormalities in chagas' disease: a meta-analysis. | chagas' disease (cd) has been associated with atrial fibrillation (af) and electrocardiographic (ecg) conduction defects. however, prior studies have shown conflicting results. we performed a meta-analysis comparing the prevalence of af and conduction abnormalities between cd and non-cd patients. | 2016 | 26412204 |
| cardiac (18)f-fdg uptake in chagas disease. | 2016 | 26122883 | |
| comparing de novo and reference-based transcriptome assembly strategies by applying them to the blood-sucking bug rhodnius prolixus. | high throughput sequencing capabilities have made the process of assembling a transcriptome easier, whether or not there is a reference genome. but the quality of a transcriptome assembly must be good enough to capture the most comprehensive catalog of transcripts and their variations, and to carry out further experiments on transcriptomics. there is currently no consensus on which of the many sequencing technologies and assembly tools are the most effective. many non-model organisms lack a refe ... | 2016 | 26005117 |
| patterns of expression of odorant receptor genes in a chagas disease vector. | rhodnius prolixus is a triatomine bug acting as a relevant vector of chagas disease for which the genome sequence has been recently made available. based on this information, a set of olfactory (ors) and ionotropic receptor (irs) genes potentially related to olfactory processes was characterized, and the expression patterns along bug development and in different structures potentially involved in promoting chemosensory-mediated behaviors were studied. for this, diverse bioinformatic procedures w ... | 2016 | 26003917 |
| identification of g protein coupled receptors for opsines and neurohormones in rhodnius prolixus. genomic and transcriptomic analysis. | the importance of chagas disease motivated the scientific effort to obtain the complete genomic sequence of the vector species rhodnius prolixus, this information is also relevant to the understanding of triatomine biology in general. the central nervous system is the key regulator of insect physiology and behavior. neurohormones (neuropeptides and biogenic amines) are the chemical messengers involved in the regulation and integration of neuroendocrine signals. in insects, this signaling is main ... | 2016 | 25976540 |
| chagas disease in a non-endemic country: a multidisciplinary research, bologna, italy. | global processes have brought about a substantial change in the epidemiological landscape of chagas disease, spreading it to non-endemic areas. italy is the second country in europe in terms of latin american migrants and expected infection rate. given that scenario, the bologna university teaching hospital undertaken a study aimed at providing preliminary data on the prevalence and investigating the knowledge and the subjective perceptions of chagas disease, migration pathways and other relevan ... | 2016 | 25935443 |
| clinical and epidemiological features of leishmaniasis in northwestern-argentina through a retrospective analysis of recent cases. | leishmaniasis is a parasitic disease caused by hemoflagellates of the genus leishmania and is transmitted to humans by the bite of infected phlebotomine sandflies. depending on the leishmania species, the disease has different clinical forms including cutaneous, mucocutaneous, and visceral manifestations. previous studies performed in endemic zones of northwestern-argentina, during epidemic outbreaks, have been important for detecting patients suffering from the acute phase of the disease, but h ... | 2016 | 26611809 |
| geographic distribution and ecology of triatoma dimidiata (hemiptera: reduviidae) in colombia. | triatoma dimidiata latreille is the second most important vector of chagas' disease in colombia and is found in urban and periurban areas. from january 2007 to june 2008, we performed field work in 8 departments, 18 municipalities, and 44 rural villages, covering most of its known distribution and all of its ecological zones in the country. the goal was to determine the geographical distribution, the ecology, and house infestation indices of t. dimidiata over its range and hence the chagas' dise ... | 2016 | 26487247 |
| galectin-3 and chagas disease-associated cardiomyopathy. | 2016 | 26464205 | |
| the amazing world of peptide engineering: the example of antimicrobial peptides from frogs and their analogues. | this review discusses the importance and properties of antimicrobial peptides from frogs and their synthetic analogues as potential therapeutic alternatives in fighting not only bacterial infections, but also protozoans involved with the major neglected diseases, which afflict human populations (e.g., chagas disease, african sleeping sickness, leishmaniasis and malaria). here, we emphasize their multifunctional properties such as promising broad-spectrum drugs that target protozoan parasites too ... | 2016 | 27262306 |
| longitudinal study of patients with chronic chagas cardiomyopathy in brazil (sami-trop project): a cohort profile. | we have established a prospective cohort of 1959 patients with chronic chagas cardiomyopathy to evaluate if a clinical prediction rule based on ecg, brain natriuretic peptide (bnp) levels, and other biomarkers can be useful in clinical practice. this paper outlines the study and baseline characteristics of the participants. | 2016 | 27147390 |
| acute colonic complications in a patient with chagas disease. | we present the case of a young bolivian woman who suffered two acute and impressive colonic complications due to a chagasic megacolon. | 2016 | 27128343 |
| inflammation enhances the risks of stroke and death in chronic chagas disease patients. | ischemic strokes have been implicated as a cause of death in chagas disease patients. inflammation has been recognized as a key component in all ischemic processes, including the intravascular events triggered by vessel interruption, brain damage and repair. in this study, we evaluated the association between inflammatory markers and the death risk (dr) and stroke risk (sr) of patients with different clinical forms of chronic chagas disease. the mrna expression levels of cytokines, transcription ... | 2016 | 27115869 |
| screening and management of children at risk for chagas disease in nonendemic areas. | 2016 | 26658625 | |
| origin, evolution and function of the hemipteran perimicrovillar membrane with emphasis on reduviidae that transmit chagas disease. | the peritrophic matrix is a chitin-protein structure that envelops the food bolus in the midgut of the majority of insects, but is absent in some groups which have, instead, an unusual extra-cellular lipoprotein membrane named the perimicrovillar membrane. the presence of the perimicrovillar membrane (pmm) allows these insects to exploit restricted ecological niches during all life stages. it is found only in some members of the superorder paraneoptera and many of these species are of medical an ... | 2016 | 26639621 |
| behavioral and toxicological responses of rhodnius prolixus (hemiptera: reduviidae) to the insect repellents deet and ir3535. | ,n-diethyl-3-methylbenzamide (deet) is a broad-spectrum insect repellent used by millions of people since the 1950s. ethyl 3-[acetyl(butyl)amino]propanoate (ir3535) is a repellent developed more recently that is still not used as extensively. this study compares the behavioral and toxicological effects of both substances in fifth-instar nymphs of the blood-sucking bug rhodnius prolixus stål (hemiptera: reduviidae), one of the main vectors of american trypanosomiasis (chagas disease). repellency ... | 2016 | 26637386 |
| new cases of chagas disease in a rural area of northeast brazilian. | chagas disease is considered one of the 17 most neglected tropical diseases in the world, with the most common form of vector transmission. | 2016 | 27192597 |
| to spray or not to spray? understanding participation in an indoor residual spray campaign in arequipa, peru. | current low participation rates in vector control programmes in arequipa, peru complicate the control of chagas disease. using focus groups (n = 17 participants) and semi-structured interviews (n = 71) conducted in march and may 2013, respectively, we examined barriers to and motivators of household participation in an indoor residual spray (irs) campaign that had taken place one year prior in arequipa. the most common reported barriers to participation were inconvenient spray times due to work ... | 2016 | 27189446 |
| ecdysis period of rhodnius prolixus head investigated using phase contrast synchrotron microtomography. | microtomography using synchrotron sources is a useful tool in biological imaging research since the phase coherence of synchrotron beams can be exploited to obtain images with high contrast resolution. this work is part of a series of works using phase contrast synchrotron microtomography in the study of rhodnius prolixus head, the insect vector of chagas' disease, responsible for about 12,000 deaths per year. the control of insect vector is the most efficient method to prevent this disease and ... | 2016 | 27184550 |
| the trypanocidal benznidazole promotes adaptive response to oxidative injury: involvement of the nuclear factor-erythroid 2-related factor-2 (nrf2) and multidrug resistance associated protein 2 (mrp2). | oxidative stress is a frequent cause underlying drug-induced hepatotoxicity. benznidazole (bzl) is the only trypanocidal agent available for treatment of chagas disease in endemic areas. its use is associated with side effects, including increases in biomarkers of hepatotoxicity. however, bzl potential to cause oxidative stress has been poorly investigated. here, we evaluated the effect of a pharmacologically relevant bzl concentration (200μm) at different time points on redox status and the cou ... | 2016 | 27180241 |
| between-country inequalities in the neglected tropical disease burden in 1990 and 2010, with projections for 2020. | the world health organization (who) has set ambitious time-bound targets for the control and elimination of neglected tropical diseases (ntds). investing in ntds is not only seen as good value for money, but is also advocated as a pro-poor policy since it would improve population health in the poorest populations. we studied the extent to which the disease burden from nine ntds (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminths, trachoma, chagas disease, human afr ... | 2016 | 27171193 |
| a co2-free synthetic host-odor mixture that attracts and captures triatomines: effect of emitted odorant ratios. | triatomines, vectors of chagas disease, are hematophagous insects. efforts have been made to develop synthetic attractants based on vertebrate odor-to lure them into traps. however, because those lures are not practical or have low capture efficiency, they are not in use in control programs. therefore, more work is needed to reach a practical and efficient odor lure. recently, a three-component, co2-free, synthetic blend of vertebrate odor (consisting of ammonia, l-(+)-lactic acid, and hexanoic ... | 2016 | 27252545 |
| identifying spatial data availability and spatial data needs for chagas disease mitigation in south america. | the objective of this paper on chagas disease is to determine the availability and spatial resolution of existing data that can be used to address chagas disease transmission risk in south america. a literature review was conducted to determine prominent variables that models utilize to assist with efforts to mitigate chagas disease. next, a web search was performed to collect publicly available spatial data pertaining to these variables for the countries in south america. the data were classifi ... | 2016 | 27246272 |
| new arrangements on several species subcomplexes of triatoma genus based on the chromosomal position of ribosomal genes (hemiptera - triatominae). | the hemipteran subfamily triatominae includes 150 blood-sucking species, vectors of chagas disease. by far the most specious genus is triatoma, assembled in groups, complexes and subcomplexes based on morphological similarities, geographic distribution and genetic data. however, many molecular studies questioned the species integration of several subcomplexes as monophyletic units. in triatomines, chromosomal position of major ribosomal dna (rdna) loci is extremely variable but seems to be speci ... | 2016 | 27245153 |
| chronic chagas' disease: targeting the interleukin-2 axis and regulatory t cells in a condition for which there is no treatment. | 2016 | 27242702 | |
| active dispersal of triatoma infestans and other triatomines in the argentinean arid chaco before and after vector control interventions. | peridomestic structures are considered the main sites where triatoma infestans (hemiptera: reduviidae) remain and disperse, representing the first risk factor for intradomestic invasion, even after vector control activities. this study analyzed t. infestans dispersal during vector control interventions in six rural houses of the arid chaco (la rioja, argentina). flying and walking dispersers were captured during five months of two consecutive warm seasons after insecticide spraying of intra- and ... | 2016 | 27232129 |
| population differentiation of the chagas disease vector triatoma maculata (erichson, 1848) from colombia and venezuela. | the emerging vector of chagas disease, triatoma maculata (hemiptera, reduviidae), is one of the most widely distributed triatoma species in northern south america. despite its increasing relevance as a vector, no consistent picture of the magnitude of genetic and phenetic diversity has yet been developed. here, several populations of t. maculata from eleven colombia and venezuela localities were analyzed based on the morphometry of wings and the mitochondrial nadh dehydrogenase subunit 4 (nd4) g ... | 2016 | 27232127 |
| benznidazole extended-release tablets for improved treatment of chagas disease: preclinical pharmacokinetic study. | benznidazole (bnz) is the first-line drug for the treatment of chagas disease. the drug is available in the form of immediate-release tablets for 100-mg (adult) and 12.5-mg (pediatric) doses. the drug is administered two or three times daily for 60 days. the high frequency of daily administrations and the long period of treatment are factors that significantly contribute to the abandonment of therapy, affecting therapeutic success. accordingly, this study aimed to evaluate the preclinical pharma ... | 2016 | 26883698 |
| neglected tropical protozoan diseases: drug repositioning as a rational option. | neglected tropical diseases represent a major sanitary problem and a huge economic burden to endemic countries, and are currently expanding to non-endemic countries owing to migration currents. though long abandoned in the past, recent research on novel therapeutics has already started to show results. drug repositioning is one of the prominent, more successful strategies to approach the development of new treatments for these diseases. here we present an overview on the limitations of the curre ... | 2016 | 26881713 |
| two cases of overlap severe cutaneous adverse reactions to benznidazole treatment for asymptomatic chagas disease in a nonendemic country. | chagas disease is a parasitosis endemic to south america. it is normally treated with benznidazole as first choice, which has been associated with numerous cutaneous reactions. however, very few benznidazole-associated severe cutaneous adverse reactions have been reported to date. the rise of chagas disease in nonendemic countries represents a growing public health challenge. we report two patients who met the criteria for drug reaction with eosinophilia and systemic symptoms syndrome and steven ... | 2016 | 26851874 |
| symbolic features and classification via support vector machine for predicting death in patients with chagas disease. | this paper introduces a technique for predicting death in patients with chagas disease using features extracted from symbolic series and time-frequency indices of heart rate variability (hrv). the study included 150 patients: 15 patients who died and 135 who did not. the hrv series were obtained from 24-h holter monitoring. sequences of symbols from 5-min epochs from series of rr intervals were generated using symbolic dynamics and ordinal pattern statistics. fourteen features were extracted fro ... | 2016 | 26851730 |
| high resolution esophageal manometry in patients with chagas disease: a cross-sectional evaluation. | gastrointestinal involvement affects 30-40% of the patients with chronic chagas disease. esophageal symptoms appear once the structural damage is established. little is known about the usefulness of high resolution manometry to early identification of esophageal involvement. | 2016 | 26848957 |
| mechanical dispersion assessed by strain echocardiography is associated with malignant arrhythmias in chagas cardiomyopathy. | sudden death is one of the characteristics of chagas disease (chd). with the development of strategies for the prevention of malignant arrhythmias, especially with implantable cardioverter-defibrillators (icds), there is interest in developing strategies to predict sudden cardiac death. the aim of this study was to test the hypothesis that global longitudinal strain (gls) and mechanical dispersion (md) may be associated with malignant ventricular arrhythmias in patients with chd. | 2016 | 26833338 |
| [industry, academia and government partnership through the global health innovative technology fund (ghit)]. | in developing countries, many people are unable to access basic healthcare services, resulting in many avoidable deaths and/or disabilities. the united nations adopted the millennium development goals in order to resolve this problem, and japan has been contributing greatly to the achievement of these goals. in this context, in 2013 the government of japan proposed its strategy on global health diplomacy, and since then has been promoting universal health coverage. since the beginning of the 21s ... | 2016 | 26831799 |
| [activity of ntds drug-discovery research consortium]. | neglected tropical diseases (ntds) are an extremely important issue facing global health care. to improve "access to health" where people are unable to access adequate medical care due to poverty and weak healthcare systems, we have established two consortiums: the ntd drug discovery research consortium, and the pediatric praziquantel consortium. the ntd drug discovery research consortium, which involves six institutions from industry, government, and academia, as well as an international non-pr ... | 2016 | 26831798 |
| [international partnership for therapeutic drug development of ntds by dndi]. | the drugs for neglected diseases initiative (dndi), with headquarters in geneva, is a non-profit drug research and development (r&d) organization and product development partnership (pdp) which was established in 2003 by 7 founding organizations such as médecins sans frontières (msf), the pasteur institute, the specific programme for research and training in tropical diseases (who-tdr), etc. dndi has worked mainly on the development of new treatments for neglected tropical diseases (ntds), which ... | 2016 | 26831796 |
| simultaneous determination of benznidazole and itraconazole using spectrophotometry applied to the analysis of mixture: a tool for quality control in the development of formulations. | the aim of this work was the development of an analytical procedure using spectrophotometry for simultaneous determination of benznidazole (bnz) and itraconazole (itz) in a medicine used for the treatment of chagas disease. in order to achieve this goal, the analysis of mixtures was performed applying the lambert-beer law through the absorbances of bnz and itz in the wavelengths 259 and 321 nm, respectively. diverse tests were carried out for development and validation of the method, which prove ... | 2016 | 26827177 |
| commercial enzyme-linked immunosorbent assay versuspolymerase chain reaction for the diagnosis of chronic chagas disease: a systematic review and meta-analysis. | chronic chagas disease diagnosis relies on laboratory tests due to its clinical characteristics. the aim of this research was to review commercial enzyme-linked immunosorbent assay (elisa) and polymerase chain reaction (pcr) diagnostic test performance. performance of commercial elisa or pcr for the diagnosis of chronic chagas disease were systematically searched in pubmed, scopus, embase, isi web, and lilacs through the bibliography from 1980-2014 and by contact with the manufacturers. the risk ... | 2016 | 26814640 |
| invasion speeds of triatoma dimidiata, vector of chagas disease: an application of orthogonal polynomials method. | demographic processes and spatial dispersal of triatoma dimidiata, a triatomine species vector of chagas disease, are modeled by integrodifference equations to estimate invasion capacity of this species under different ecological conditions. the application of the theory of orthogonal polynomials and the steepest descent method applied to these equations, allow a good approximation of the abundance of the adult female population and the invasion speed. we show that: (1) under the same mean condi ... | 2016 | 26807809 |
| biostable insect kinin analogs reduce blood meal and disrupt ecdysis in the blood-gorging chagas' disease vector, rhodnius prolixus. | rhodnius prolixus is a blood-gorging hemipteran that takes blood meals that are approximately 10 times its body weight. this blood meal is crucial for growth and development and is needed to ensure a successful molt into the next instar. kinins are a multifunctional family of neuropeptides which have been shown to play a role in the control of feeding in a variety of insects. in this study, two biostable aib-containing kinin analogs were tested to see if they interfere with blood-feeding and sub ... | 2016 | 26807486 |
| chagas heart disease in professional athletes from endemic countries: a notorious case calls attention for its identification and stratification. | 2016 | 26800129 | |
| chronic chagas disease: can prophylaxis and therapeutic vaccines crack this 'hard nut'? | 2016 | 26787323 | |
| a global systematic review of chagas disease prevalence among migrants. | human migration has been identified as a potential factor for increased chagas disease risk and has transformed the disease from a latin american problem to a global one. we conducted a systematic review of the scientific literature between 2004-2014 in order to: summarize recent seroprevalence estimates of chagas disease among latin american migrants, in both endemic and non-endemic settings; compare seroprevalence estimates in migrants to countrywide prevalence estimates; and identify risk fac ... | 2016 | 26777312 |
| new approach towards the synthesis of selenosemicarbazones, useful compounds for chagas' disease. | herein, we describe a new approach towards the synthesis of selenosemicarbazones. the reaction involves an o-se exchange of semicarbazones using ishihara reagent. eleven selenosemicarbazones were prepared using this methodology, with low to moderate yields. among the prepared compounds the m-bromo phenyl methyl derivative 1b was selected to be evaluated in vivo, in a murine model of acute chagas' disease. compound 1b 10 mg/kg bw/day reduced 50% of parasitaemia profile compared with the control g ... | 2016 | 26774036 |
| dynamics of expression of two vitellogenin genes in the chagas' disease vector triatoma infestans: analysis throughout pre-vitellogenesis and vitellogenesis. | the reproductive success of all oviparous species depends on vitellogenin (vg) biosynthesis and its accumulation in the developing oocytes. the expression levels of two vg genes (vg1 and vg2) were analyzed by qpcr and western blot in fat body and ovaries of adult females, at different times after ecdysis (pre-vitellogenic phase) and after blood feeding of females (vitellogenic phase). vg genes were also evaluated in fat bodies of adult males as well as in female fifth instar nymphs. no trace of ... | 2016 | 26772448 |
| low incidence of adverse effects using a progressive regimen of benznidazole in chagas disease. | 2016 | 26769725 | |
| the role of light in chagas disease infection risk in colombia. | chagas disease is the most important vector-borne disease in latin america and rhodnius prolixus is the main vector in colombia. control strategies in this region have shown poor outcomes due to the insect's ability to disperse between the sylvatic and the domestic habitat. because insect migration to houses is responsible to sustain contact rates between vectors and humans, understanding the risk factors that promote migration could be important in designing control strategies. in this respect, ... | 2016 | 26732186 |
| altered hypercoagulability factors in patients with chronic chagas disease: potential biomarkers of therapeutic response. | thromboembolic events were described in patients with chagas disease without cardiomyopathy. we aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. ninety-nine individuals from chagas disease-endemic areas were classified in two groups: g1, with t.cruzi infection (n = 56); g2, healthy individuals (n = 43). twenty-four hemostasis factors were measured at baseline. g1 patients ... | 2016 | 26727000 |
| new serological tools for improved diagnosis of human tegumentary leishmaniasis. | human tegumentary leishmaniasis (htl), characterized by skin ulcers that may spread and cause dreadful and massive tissue destruction of the nose and mouth, is considered a neglected tropical disease, and it is a serious threat to global health due to its continuous expansion, favored by the lifecycle of its causative organism that is maintained in domestic animal reservoirs and anthropophilic sand fly species. serodiagnosis of htl is a great challenge due to many biological factors, including h ... | 2016 | 27090730 |
| analysis of regional left ventricular strain in patients with chagas disease and normal left ventricular systolic function. | chagas heart disease has a high socioeconomic burden, and any strategy to detect early myocardial damage is welcome. speckle-tracking echocardiography assesses global and segmental left ventricular (lv) systolic function, yielding values of two-dimensional strain (ε). the aim of this study was to determine if patients with chronic chagas disease and normal lv ejection fractions present abnormalities in global and segmental lv ε. | 2016 | 27086044 |
| stairway to heaven or hell? perspectives and limitations of chagas disease chemotherapy. | in this review, we intend to provide a general view of the evolution of experimental studies in the area of chemotherapy for chagas disease. we can follow the process of drug development through three phases. the first phase began almost at the same time as the discovery made by carlos chagas and proceeds to 1970, during which time an extensive list of compounds was subjected to preclinical and clinical trials. the second phase began with the introduction of nifurtimox and benznidazole into the ... | 2016 | 27072716 |
| geological changes of the americas and their influence on the diversification of the neotropical kissing bugs (hemiptera: reduviidae: triatominae). | the family reduviidae (hemiptera: heteroptera), or assassin bugs, is among the most diverse families of the true bugs, with more than 6,000 species. the subfamily triatominae (kissing bugs) is noteworthy not simply because it is the only subfamily of the reduviidae whose members feed on vertebrate blood but particularly because all 147 known members of the subfamily are potential chagas disease vectors. due to the epidemiological relevance of these species and the lack of an efficient treatment ... | 2016 | 27058599 |