Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [four cases of non-clostridial gas gangrene with diabetes mellitus]. | we report four cases of non-clostridial gas gangrene. all cases were associated with diabetes mellitus as the underlying disease. case 1: a 60-year-old male developed an ulcerative lesion on the dorsum of his left foot. peptostreptococcus asaccharolyticus, citrobacter freundii and staphyrococcus epidermidis were identified in culture from odoriferous pus. case 2: a 81-year-old female developed a lesion on her vulva spreading to the right lower abdomen. bacteroides bivius, peptostreptococcus asac ... | 2002 | 11915237 |
| acute suppurative thyroiditis caused by an infected piriform sinus fistula with thyrotoxicosis. | we report herein an unusual case of thyrotoxicosis caused by acute suppurative thyroiditis (ast) infected through a piriform sinus fistula (psf). a 28-year-old man presented with pain over the thyroid gland and elevated serum thyroid hormone levels, a picture similar to subacute thyroiditis. a fine-needle aspiration biopsy from the left lobe showed neutrophil infiltration, and culture from the aspirate grew anaerobic peptostreptococcus. a neck computed tomography (ct) scan showed an abscess in t ... | 2002 | 11916288 |
| management of acute suppurative parotitis. | 2002 | 11928106 | |
| bacteriology and antimicrobial susceptibility of gram-positive cocci isolated from pus specimens of orofacial odontogenic infections. | we recently reported the beta-lactamase production and antimicrobial susceptibility of anaerobic gram-negative rods isolated from pus specimens of 93 orofacial odontogenic infections. in this report, we determine the bacteriology and antimicrobial susceptibility of bacteria other than anaerobic gram-negative rods, mainly gram-positive cocci, isolated from the same specimens. streptococcus constellatus and peptostreptococcus micros were frequent isolates from all types of infection examined. pept ... | 2002 | 11929563 |
| treatment of papillon-lefèvre syndrome periodontitis. | conventional mechanical treatment of papillon-lefèvre syndrome periodontitis has a poor prognosis. this report describes an effective antimicrobial treatment of rapidly progressing periodontitis in an 11-year old girl having papillon-lefèvre syndrome. | 2002 | 11966936 |
| [post-marketing surveillance of antibacterial activities of cefozopran against various clinical isolates--i. gram-positive bacteria]. | as a post-marketing surveillance, the in vitro antibacterial activities of cefozopran (czop), an agent of cephems, against various clinical isolates were yearly evaluated and compared with those of other cephems, oxacephems, penicillins, and carbapenems. changes in the bacterial sensitivity for czop were also evaluated with the resistance ratio calculated with breakpoint mic. sixteen species (1,913 strains) of gram-positive bacteria were isolated from the clinical materials annually collected fr ... | 2002 | 11977919 |
| quantitative microbiological study of human carious dentine by culture and real-time pcr: association of anaerobes with histopathological changes in chronic pulpitis. | the bacteria found in carious dentine were correlated with the tissue response of the dental pulps of 65 teeth extracted from patients with advanced caries and pulpitis. standardized homogenates of carious dentine were plated onto selective and nonselective media under anaerobic and microaerophilic conditions. in addition, real-time pcr was used to quantify the recovery of anaerobic bacteria. primers and fluorogenic probes were designed to detect the total anaerobic microbial load, the genera pr ... | 2002 | 11980945 |
| bacteriology of acute and chronic frontal sinusitis. | aspirates of 15 acutely and 13 chronically infected frontal sinuses were processed for aerobic and anaerobic bacteria. a total of 20 isolates (1.3 per specimen) were recovered from the 15 cases of acute frontal sinusitis, 16 aerobic and facultative isolates (1.1 per specimen) and 4 anaerobic isolates (0.3 per specimen). aerobic and facultative organisms alone were recovered in 13 specimens (87%), and mixed aerobic and anaerobic bacteria were recovered in 2 (13%). the predominant aerobic and facu ... | 2002 | 12003592 |
| in vitro bactericidal activity and post-antibiotic effect of abt-773 versus co-amoxiclav against anaerobes. | 2002 | 12003989 | |
| the effects of an immediately pre-surgical chlorhexidine oral rinse on the bacterial contaminants of bone debris collected during dental implant surgery. | dental implant surgery produces bone debris that can be used in the "simultaneous augmentation" technique. although this debris is contaminated with oral bacteria, a stringent aspiration protocol has been shown to reduce the levels of contamination. chlorhexidine mouthrinse is a well-proven antibacterial rinse that has been shown to reduce infectious complications associated with dental implants. this study examined the effect of pre-operative rinsing with a 0.1% chlorhexidine digluconate mouthr ... | 2002 | 12005141 |
| parotid salivary s-iga antibodies during experimental gingivitis in smokers and non-smokers. | persons who smoke display a less pronounced increase of gingival bleeding in the experimental gingivitis model as compared with non-smokers. the aim of the present study was to investigate whether this could partly be explained by differences in levels of parotid total secretory iga (s-iga) or parotid s-iga reactive with selected oral microorganisms. parotid saliva samples were obtained from 11 smoking and 14 non-smoking volunteers, at baseline, after 5 and 14 days of full mouth experimental gin ... | 2002 | 12009188 |
| mice lacking monocyte chemoattractant protein 1 have enhanced susceptibility to an interstitial polymicrobial infection due to impaired monocyte recruitment. | monocyte chemoattractant protein 1 (mcp-1) is an important chemokine that induces monocyte recruitment in a number of different pathologies, including infection. to investigate the role of mcp-1 in protecting a host from a chronic interstitial polymicrobial infection, dental pulps of mcp-1(-/-) mice and controls were inoculated with six different oral pathogens. in this model the recruitment of leukocytes and the impact of a genetic deletion on the susceptibility to infection can be accurately a ... | 2002 | 12011011 |
| aerobic and anaerobic microbiology of suppurative sialadenitis. | aspirates of pus from acute suppurative sialadenitis were investigated for the presence of aerobic and anaerobic bacteria. a total of 47 specimens, 32 from parotid, 9 from submandibular and 6 from sublingual glands yielded bacterial growth. fifty five isolates, 25 aerobic and 30 anaerobic, were isolated from parotid infection: anaerobic bacteria only were detected in 13 (41%) specimens, aerobic or facultative bacteria only in 11 (34%) and mixed aerobic and anaerobic bacteria in 8 (25%). of a tot ... | 2002 | 12018662 |
| physical and genetic map of the finegoldia magna (formerly peptostreptococcus magnus) atcc 29328 genome. | a physical and genetic map of finegoldia magna (formerly peptostreptococcus magnus) atcc 29328 chromosome was constructed. the order of rare cleavage restriction fragments was determined by double digestion with the restriction enzymes i-ceui, sgrai, apai and pmei, cross-hybridization and apai-linking clones. the size of the circular chromosome of f. magna was estimated to be 1.9 mb. this strain also had a 200-kb megaplasmid. the chromosome contained four rrn operons, and the orientation of two ... | 2002 | 12023074 |
| deuterium spin probes of side-chain dynamics in proteins. 1. measurement of five relaxation rates per deuteron in (13)c-labeled and fractionally (2)h-enriched proteins in solution. | new pulse sequences are presented for the measurement of the relaxation of deuterium double quantum, quadrupolar order, and transverse antiphase magnetization in (13)ch(2)d methyl groups of (15)n-, (13)c-labeled, fractionally deuterated proteins. together with previously developed experiments for measuring deuterium longitudinal and transverse decay rates [muhandiram, d. r.; yamazaki, t.; sykes, b. d.; kay, l. e. j. am. chem. soc. 1995, 117, 11536], these schemes allow measurement of the five un ... | 2002 | 12033875 |
| deuterium spin probes of side-chain dynamics in proteins. 2. spectral density mapping and identification of nanosecond time-scale side-chain motions. | in the previous paper in this issue we have demonstrated that it is possible to measure the five different relaxation rates of a deuteron in (13)ch(2)d methyl groups of (13)c-labeled, fractionally deuterated proteins. the extensive set of data acquired in these experiments provides an opportunity to investigate side-chain dynamics in proteins at a level of detail that heretofore was not possible. the data, acquired on the b1 domain of peptostreptococcal protein l, include 16 (9) relaxation measu ... | 2002 | 12033876 |
| reclassification of clostridium hydroxybenzoicum as sedimentibacter hydroxybenzoicus gen. nov., comb. nov., and description of sedimentibacter saalensis sp. nov.. | strain zf2t, isolated from freshwater sediment, is a motile, rod-shaped, gram-positive, endospore-forming, amino acid- and pyruvate-utilizing, anaerobic bacterium. it requires yeast extract for growth. carbohydrates are not utilized. the optimal temperature and ph for growth are 37 degrees c and 6.8-7.3, respectively. the g+c content of the dna is 34.0 mol %. a 16s rdna sequence analysis of strain zf2t revealed that the highest similarity (94.4%) was shared with clostridium hydroxybenzoicum jw/z ... | 2002 | 12054241 |
| effect of deuteration on some structural parameters of methyl groups in proteins as evaluated by residual dipolar couplings. | one bond methyl 1h-13c and 13cmethyl-13c scalar and residual dipolar couplings have been measured at sites in an 15n, 13c, approximately 50% 2h labeled sample of the b1 immunoglobulin binding domain of peptostreptococcal protein l to investigate changes in the structure of methyl groups in response to deuterium substitution. both one bond methyl 1h-13c and 13cmethyl-13c scalar coupling constants have been found to decrease slightly with increasing deuterium content. previous studies have shown t ... | 2002 | 12061716 |
| [clinical aspects of abscess development in parotitis]. | the purpose of this paper was to analyse parotideal abscesses on the basis of a larger number of patients. | 2002 | 12063691 |
| [sensitivity of the folding pathway to the details of amino acid sequence]. | experimental data on the structure of transition state demonstrate that the proteins with the same topology as a rule have similar folding nuclei (the structured formed part of the transition state). in this review we discuss the experimental works which show that the position of folding nuclei is different among proteins with the same topology. these facts underline that the folding pathway is sensitive to the details of amino-acid sequence. | 2002 | 12068621 |
| [yearly changes in antibacterial activities of cefozopran against various clinical isolates between 1996 and 2000--i. gram-positive bacteria]. | the in vitro antibacterial activities of cefozopran (czop), an agent of cephems, against various clinical isolates obtained between 1996 and 2000 were yearly evaluated and compared with those of other cephems, oxacephems, carbapenems, and penicillins. fifteen species, 1,062 strains, of gram-positive bacteria were isolated from the clinical materials annually collected from january to december, and consisted of methicillin-susceptible staphylococcus aureus (mssa; n = 127), methicillin-resistant s ... | 2002 | 12071093 |
| peptostreptococcal pericarditis complicating anti-tumour necrosis factor alpha treatment in rheumatoid arthritis. | 2002 | 12079913 | |
| invasion of dentinal tubules by oral bacteria. | bacterial invasion of dentinal tubules commonly occurs when dentin is exposed following a breach in the integrity of the overlying enamel or cementum. bacterial products diffuse through the dentinal tubule toward the pulp and evoke inflammatory changes in the pulpo-dentin complex. these may eliminate the bacterial insult and block the route of infection. unchecked, invasion results in pulpitis and pulp necrosis, infection of the root canal system, and periapical disease. while several hundred ba ... | 2002 | 12097359 |
| bacterial superinfection in human tungiasis. | tungiasis is caused by penetration of the female sand flea tunga penetrans into the epidermis of its host. it is endemic in many countries in latin america, the caribbean and sub-saharan africa. although superinfection is a common clinical observation, the frequency and the pattern of bacterial pathogens associated with tungiasis have never been investigated systematically. we conducted a prospective clinico-bacteriological study with patients living in a shantytown in fortaleza, capital of cear ... | 2002 | 12100437 |
| actinobacillus actinomycetemcomitans proportion of subgingival bacterial flora in relation to its clonal type. | we investigated whether certain actinobacillus actinomycetemcomitans clones occur in elevated proportions in subgingival flora, and if the proportions relate to other bacteria in the samples. a total of 121 a. actinomycetemcomitans strains from 121 patients with periodontitis were serotyped and 60 strains were also genotyped. the 121 strains were divided into three groups and the 60 strains into two groups according proportion of a. actinomycetemcomitans. the samples from the 60 patients with ge ... | 2002 | 12120706 |
| cutaneous and subcutaneous infections in newborns due to anaerobic bacteria. | this review describes the microbiology and management of the major cutaneous and subcutaneous infections in newborns where anaerobic bacteria predominate: omphalitis, necrotizing fasciitis, breast abscess, and scalp infection following intrauterine fetal monitoring. the predominant bacteria known to cause these infections are group b streptococcus, group d enterococcus, group a streptococcus, staphylococcus aureus, enterobacteriaceae, and anaerobic bacteria. all of these agents can colonize or i ... | 2002 | 12122901 |
| clinical review: bacteremia caused by anaerobic bacteria in children. | this review describes the microbiology, diagnosis and management of bacteremia caused by anaerobic bacteria in children. bacteroides fragilis, peptostreptococcus sp., clostridium sp., and fusobacterium sp. were the most common clinically significant anaerobic isolates. the strains of anaerobic organisms found depended, to a large extent, on the portal of entry and the underlying disease. predisposing conditions include: malignant neoplasms, immunodeficiencies, chronic renal insufficiency, decubi ... | 2002 | 12133179 |
| design and evaluation of oligonucleotide-microarray method for the detection of human intestinal bacteria in fecal samples. | an oligonucleotide-microarray method was developed for the detection of intestinal bacteria in fecal samples collected from human subjects. the 16s rdna sequences of 20 predominant human intestinal bacterial species were used to design oligonucleotide probes. three 40-mer oligonucleotides specific for each bacterial species (total 60 probes) were synthesized and applied to glass slides. cyanine5 (cy5)-labeled 16s rdnas were amplified by polymerase chain reaction (pcr) from human fecal samples or ... | 2002 | 12167534 |
| randomized, double-blind, multicenter comparison of oral cefditoren 200 or 400 mg bid with either cefuroxime 250 mg bid or cefadroxil 500 mg bid for the treatment of uncomplicated skin and skin-structure infections. | uncomplicated skin and skin-structure infections are commonly observed in medical practice. because these infections typically are confined to the superficial layers and seldom lead to the destruction of skin structures and resultant systemic dissemination, in general they can be treated with an oral antibiotic with potent microbiologic activity against gram-positive pathogens. | 2002 | 12182257 |
| combinations of bacterial species in endodontic infections. | this study was undertaken to investigate combinations of bacteria found in root-canal infections of teeth with periapical bone destruction without clinical signs and symptoms. | 2002 | 12196223 |
| genotypic diversity of clinical actinomyces species: phenotype, source, and disease correlation among genospecies. | we determined the frequency distribution of actinomyces spp. recovered in a routine clinical laboratory and investigated the clinical significance of accurate identification to the species level. we identified 92 clinical strains of actinomyces, including 13 strains in the related arcanobacterium-actinobaculum taxon, by 16s rrna gene sequence analysis and recorded their biotypes, sources, and disease associations. the clinical isolates clustered into 21 genogroups. twelve genogroups (74 strains) ... | 2002 | 12202591 |
| comparative in vitro activity of faropenem and 11 other antimicrobial agents against 405 aerobic and anaerobic pathogens isolated from skin and soft tissue infections from animal and human bites. | faropenem, a new oral beta-lactam agent with a penem structure, was very active against 405 aerobic and anaerobic bite isolates. it inhibited 232 of 236 (98%) aerobic isolates, including all pasteurella spp. and eikenella corrodens at < or = 0.25 mg/l, and 164/169 (97%) anaerobic isolates, at < or = 1 mg/l. the 10 isolates that required > or = 2 mg/l for inhibition were one strain each of acinetobacter lwoffi, corynebacterium minutissimum, bacteroides ovatus, lactobacillus delbrueckii and peptos ... | 2002 | 12205068 |
| [two cases of empyema caused by peptostreptococcus]. | 2002 | 12611246 | |
| [bacteria isolated from surgical infections and their susceptibilities to antimicrobial agents. special references to bacteria isolated between april 1999 and march 2000]. | the annual multicenter studies on isolated bacteria from infections in general surgery and their antimicrobial susceptibility have been conducted in japan since july 1982. in this paper, the results obtained in the academic year 1999 (from april 1999 to march 2000) have been summarized. two hundred seven cases were investigated, and 411 strains were isolated from 169 cases (81.6%). of those strains, 184 and 227 strains were from primary infections and postoperative infections, respectively. in p ... | 2002 | 12621728 |
| [bacteria isolated from surgical infections and their susceptibilities to antimicrobial agents--special references to bacteria isolated between april 2000 and march 2001]. | tendency of isolated bacteria from infections in general surgery and their antimicrobial susceptibilities during the period from april 2000 to march 2001 were investigated in a multicenter study in japan, and the following results were obtained. the number of cases investigated as objectives was 234 for one year. a total of 388 strains (136 strains from primary infections and 252 strains from postoperative infections) were isolated from 165 cases (70.5% of total cases). in primary infections, an ... | 2002 | 12621729 |
| [antibacterial activity of cefpodoxime against clinical isolates in 2000 and 2001]. | as the post-marketing surveillance of cefpodoxime proxetil (banan), mics of cefpodoxime (cpdx, an active form of banan) against 1090 clinical isolates of 22 species from 15 medical institutions all over japan from june 2000 to march 2001 were measured using the broth microdilution method approved by the japanese society of chemotherapy and compared with those of oral cephem antibacterials, cefaclor, cefdinir, cefditoren, and cefcapene. in this study, remarkable change in the activity of cpdx was ... | 2002 | 12621736 |
| [identification and susceptibility to antimicrobial agents of strictly anaerobic bacteria isolated from hospitalized patients]. | the aim of this study was to identify anaerobic strains isolated in 2001 from clinical specimens obtained from patients of warsaw hospital and to evaluate a susceptibility of these strains to antimicrobial agents. in 2001 two hundred and twenty five clinical strains of obligate anaerobes were cultured, which were identified in the automatic atb system (biomérieux, france) using biochemical tests api 20 a. drug-susceptibility of strains was determined also in atb system with the use of atb ana st ... | 2002 | 12632658 |
| actinomycotic bacteraemia after dental procedures. | to assess role of oral flora in causing bacteraemia following dental manipulations. | 2002 | 17657035 |
| anaerobes in pleuropulmonary infections. | a total of 76 anaerobes and 122 aerobes were isolated from 100 patients with pleuropulmonary infections, e.g. empyema (64), pleural effusion (19) and lung abscess (13). in 14% of the patients, only anaerobes were recovered, while a mixture of aerobes and anaerobes was encountered in 58%. from all cases of lung abscess, anaerobic bacteria were isolated, alone (04) or along with aerobic bacteria (13). from empyema and pleural effusion cases, 65.6% and 68.4% anaerobes were recovered respectively. a ... | 2002 | 17657055 |
| bacterial diversity in necrotizing ulcerative periodontitis in hiv-positive subjects. | necrotizing ulcerative periodontitis (nup) is a painful and potentially debilitating affliction that affects about 2% to 6% of hiv-positive subjects. nup may be caused by specific microorganisms that are presently unknown or by microbial species not usually thought to cause periodontal infections. the purpose of this study was to define the bacterial species associated with nup in hiv-positive patients. | 2002 | 16013212 |
| taxonomy--general comments and update on taxonomy of clostridia and anaerobic cocci. | since such things as sites of normal carriage, type and severity of infections produced, and antimicrobial susceptibility patterns may vary according to the particular species involved, accurate taxonomy for differentiation of species is important. for example, reclassification of the 'bacteroides gracilis group' revealed that sutterella wadsworthensis is actually responsible for the antimicrobial resistance seen in that group. with clostridia and anaerobic cocci, as with other taxa, there have ... | 2002 | 16887670 |
| phospholipid analogue profiles of peptostreptococcus, micromonas, and finegoldia species analysed by fast atom bombardment mass spectrometry. | species of peptostreptococcus cause a variety of infections, primarily abscesses of soft tissues, joints, and mucous membranes. the aim of this study was to compare the phospholipid analogue profiles of peptostreptococcus species, represented by p. anaerobius, p. asaccharolyticus, p. indolicus, p. lacrimalis, and p. prevotii; micromonas micros (p. micros) and finegoldia magna (p. magnus). after anaerobic growth on blood-faa, lipids extracted by chloroform-methanol (2:1 v/v) were purified, then a ... | 2001 | 15049457 |
| ocular infections due to anaerobic bacteria. | the increased recovery of anaerobic bacteria in clinical infection has led to greater appreciation of these organisms in ocular infections. in studies that employed adequate method for recovery of anaerobes they were isolated from about a third of patients with conjunctivitis, half of the time in pure culture. the predominant recovered anaerobes were clostridium spp., gram-negative anaerobic bacilli, and peptostreptococcus spp. anaerobic bacteria were also recovered from patients who wore contac ... | 2001 | 14531629 |
| identification of predominant human and animal anaerobic intestinal bacterial species by terminal restriction fragment patterns (trfps): a rapid, pcr-based method. | identification of predominant human and animal intestinal tract anaerobes by conventional methods is cumbersome, time-consuming and less sensitive as compared to molecular methods. we have developed a molecular technique to identify most of the abundant intestinal microflora by polyermase chain reaction (pcr) amplification of a 16s rrna gene fragment using a pair of universal pcr primers. the forward pcr primer was labelled with 6-carboxyfluorescein amino hexy (6-fam) fluorescent dye to detect t ... | 2001 | 11851378 |
| [the microflora of ulzerous zone mucosa in patients with duodenal ulcer]. | bacteriological study of the biopsies taken from gastric and duodenal mucosa of 10 healthy volunteers and 74 patients with duodenal ulcer, was carried out. in the gastroduodenal zone of healthy subjects microorganisms of 6 genera (streptococcus, candida, staphylococcus, bacillus, helicobacter and lactobacillus) were detected. h. pylori was isolated in 20% of cases only in biopsy specimens taken from the antral section of the stomach of healthy as monoculture or in combination with c. albicans. i ... | 2001 | 11871291 |
| [a comparative study of various evaluation methods of the antibiotic sensitivity of strict anaerobic bacteria of the subgingival flora]. | the study on the sensitiveness of slow-growing anaerobes bacteria to antibiotics is delicate when you consider the technical motives that make it difficult to transpose the standard methods frequently used in microbiological laboratories. the three main methods used to determine susceptibility to antibiotics are: disk-diffusion test, antibiotics containing microdilution plates and atb ana (biomérieux). the aim of this study is to compare the effectiveness of each of these methods on severe anaer ... | 2001 | 11808376 |
| the microbiology of mucopyocele. | to evaluate the aerobic and anaerobic microbiology of mucopyocele. | 2001 | 11801943 |
| [use of the etest method for antimicrobial susceptibility testing of obligate anaerobes]. | the aim of this study was to evaluate etest usefulness for antimicrobial susceptibility testing of obligate anaerobes and to compare the activity of five antibacterial drugs against clinical strains of anaerobes. one hundred strains of obligate anaerobes were tested: 2 reference strains (b. fragilis atcc 25285 and b. thetaiotaomicron atcc 29741) and 98 clinical strains isolated from patients of the infant jesus clinical hospital--center for trauma treatment in warsaw during the last three years ... | 2001 | 11757426 |
| aggressive periodontitis associated with fanconi's anemia. a case report. | fanconi's anemia is an autosomal recessive disease associated with chromosomal breakage as well as pancytopenia, skin pigmentation, renal hypoplasia, cardiac defects, microcephaly, congenital malformations of the skeleton, hypogonadism, and increased risk of leukemia. the present report describes the periodontal clinical and microbiological status of an 11-year old male having fanconi's anemia. | 2001 | 11759873 |
| the bacterial flora in inflammatory bowel disease: current insights in pathogenesis and the influence of antibiotics and probiotics. | the pathogenesis of inflammatory bowel disease (ibd) remains unknown, although in recent years more data have become available. the contribution of genetic and environmental factors is evident, and the luminal bacterial flora plays a major role in the initiation and perpetuation of chronic ibd. animal models of ibd have shown that colitis does not occur in a germ-free environment. in human ibd, inflammation is present in parts of the gut containing the highest bacterial concentrations. moreover, ... | 2001 | 11768558 |
| [bacteria isolated from surgical infections and their susceptibilities to antimicrobial agents. special references to bacteria isolated between april 1998 and march 1999]. | the annual multicenter studies on isolated bacteria from infections in general surgery and their antimicrobial susceptibility have been conducted in japan since july 1982. this paper describes the results obtained in fiscal 1998 (from april 1998 to march 1999). the number of cases investigated as objectives was 225 for one year. a total of 429 strains (121 strains from primary infections and 308 strains from postoperative infections) were isolated from 183 cases (81.3% of total cases). in primar ... | 2001 | 11771334 |
| ertapenem: a new carbapenem. | ertapenem is a new 1-beta-methyl carbapenem, stable to dehydropeptidase, which binds preferable to penicillin-binding proteins (pbp) 2 and 3. ertapenem has a broad antibacterial spectrum with mic90 values < 0.5 mg/l for penicillin-susceptible streptococcus pneumoniae, streptococcus pyogenes, methicillin-sensitive staphylococcus aureus, haemophilus influenzae, moraxella catarrhalis, escherichia coli, citrobacter spp., klebsiella spp., serratia spp., proteus spp., clostridium perfringens, fusobact ... | 2001 | 11772242 |
| single-site mutations induce 3d domain swapping in the b1 domain of protein l from peptostreptococcus magnus. | thermodynamic and kinetic studies of the protein l b1 domain (ppl) suggest a folding pathway in which, during the folding transition, the first beta hairpin is formed while the second beta hairpin and the alpha helix are largely unstructured. the same mutations in the two beta turns have opposite effects on the folding and unfolding rates. three of the four residues composing the second beta turn in ppl have consecutive positive phi angles, indicating strain in the second beta turn. | 2001 | 11709166 |
| [antimicrobial activities of carbapenems and fourth generation cephems against clinically isolated strains]. | we determined the antibacterial activities of 4 carbapenems (imipenem, panipenem, meropenem and biapenem) and 2 forth generation cephems (cefozopran and cefepime) against 850 bacterial strains (18 species) isolated during the period from january 1998 through september 2000. the 4 carbapenems showed excellent antibacterial activities against methicillin-susceptible s. aureus (mssa), s. pneumoniae, e. faecalis, p. aeruginosa, m. (b). catarrhalis, b. fragilis and peptostreptococcus spp. as compared ... | 2001 | 11729712 |
| association of early onset periodontitis microbiota with aspartate aminotransferase activity in gingival crevicular fluid. | the objective of this study was to determine the relationship between the activity of the enzyme aspartate aminotransferase (ast) in gingival crevicular fluid (gcf) using the colorimetric periogard (ptm) test and the subgingival microflora in early onset periodontitis lesions. | 2001 | 11737506 |
| supragingival and subgingival microbiota of adult patients with down's syndrome. changes after periodontal treatment. | in this longitudinal study, five adult down's syndrome patients with periodontitis were placed on a frequent recall visit schedule (every 6 weeks) after treatment, in order to investigate: 1) the microbiological status, both supragingivally and subgingivally, and the changes that occurred after treatment and 2) the effect of frequent professional supragingival plaque control on the subgingival microbiota and clinical variables in these patients. the clinical variables recorded were probing pocke ... | 2001 | 11737662 |
| splenic abscess caused by peptostreptococcus species, diagnosed with the aid of abdominal computerized tomography and treated with percutaneous drainage and antibiotics: a case report. | we describe herein a 63-year-old patient with a splenic abscess due to peptostreptococcus spp., diagnosed with the aid of abdominal computerised tomography and treated with ultra-sound guided percutaneous drainage and antibiotics. the bacteriological characteristics of splenic abscesses are discussed. | 2001 | 11744179 |
| smoking and subgingival microflora in periodontal disease. | the present investigation was undertaken to analyze the influence of smoking on the periodontal disease associated subgingival microflora. the population included 33 smokers and 31 non-smokers in the age range 36-86 years. | 2001 | 11284533 |
| antagonism against vibrio cholerae by diffusible substances produced by bacterial components of the human faecal microbiota. | cholera vibrios sometimes survive, probably in low-level silent populations, in the small intestine of chronic carriers or pass through the gastrointestinal tract of a few individuals without causing diarrhoea or colonisation. to understand these situations, the present study used plate cultures (ex-vivo test) to investigate the frequency of appearance of an inhibitory halo against vibrio cholerae produced by faecal specimens from 92 healthy volunteers (40 females, 52 males) aged 4-61 years. the ... | 2001 | 11211223 |
| correlation between microbiology and previous sinus surgery in patients with chronic maxillary sinusitis. | aspirates of 108 chronically inflamed maxillary sinuses were processed for aerobic and anaerobic bacteria. there were 295 bacterial isolates: 109 aerobic and facultative, and 186 anaerobic. the predominant aerobic isolates were staphylococcus aureus (17 isolates), alpha-hemolytic streptococci (14), pseudomonas aeruginosa (12), moraxella catarrhalis (10), and haemophilus spp (8). the predominant anaerobes were peptostreptococcus spp (61), prevotella spp (45), fusobacterium spp (15), and propionib ... | 2001 | 11219522 |
| detection of peptostreptococcus micros dna in clinical samples by pcr. | peptostreptococcus micros is a gram-positive anaerobic coccus which, although considered to be a natural commensal of the human oral cavity, is associated with periodontal, endodontal and peritonsillar infections. identification of the organism has to date relied upon conventional culture methods and biochemical analyses. the purpose of this study was to develop a pcr method for rapid and specific identification of this organism in clinical samples. a pair of primers was selected, each of which ... | 2001 | 11232771 |
| microorganisms isolated from root canals presenting necrotic pulp and their drug susceptibility in vitro. | the knowledge about causative agents involved in endodontic infections is increasing, especially due to the improvement of culture techniques for anaerobic bacteria, showing that these microorganisms are predominant in this pathology. in this study, 31 canals with pulp necrosis were microbiologically analyzed before and after manipulation. obligate and facultative anaerobes, microaerophilic bacteria and yeasts were recovered from 24, 14, 5 and 2 clinical specimens, respectively. the most frequen ... | 2001 | 11240863 |
| microbial analysis of bone collected during implant surgery: a clinical and laboratory study. | dental implant surgery produces bone debris which can be used to correct bone defects in the "simultaneous-augmentation" technique. however, this debris is potentially contaminated with oral bacteria. therefore, this study examined bone debris collected during dental implant surgery in order 1) to identify the microbial contaminants and 2) to compare the effects of two different aspiration protocols on the levels of microbial contamination. twenty-four partially dentate patients were randomly al ... | 2001 | 11251657 |
| multicenter survey of the changing in vitro antimicrobial susceptibilities of clinical isolates of bacteroides fragilis group, prevotella, fusobacterium, porphyromonas, and peptostreptococcus species. | in vitro surveys of antimicrobial resistance among clinically important anaerobes are an important source of information that can be used for clinical decisions in the choice of empiric antimicrobial therapy. this study surveyed the susceptibilities of 556 clinical anaerobic isolates from four large medical centers using a broth microdilution method. piperacillin-tazobactam was the only antimicrobial agent to which all the isolates were susceptible. similarly, imipenem, meropenem, and metronidaz ... | 2001 | 11257040 |
| statistical theory for protein combinatorial libraries. packing interactions, backbone flexibility, and the sequence variability of a main-chain structure. | combinatorial experiments provide new ways to probe the determinants of protein folding and to identify novel folding amino acid sequences. these types of experiments, however, are complicated both by enormous conformational complexity and by large numbers of possible sequences. therefore, a quantitative computational theory would be helpful in designing and interpreting these types of experiment. here, we present and apply a statistically based, computational approach for identifying the proper ... | 2001 | 11178917 |
| structures of the b1 domain of protein l from peptostreptococcus magnus with a tyrosine to tryptophan substitution. | the three-dimensional structure of a tryptophan-containing variant of the igg-binding b1 domain of protein l has been solved in two crystal forms to 1.7 and 1.8 a resolution. in one of the crystal forms, the entire n-terminal histidine-tag region was immobilized through the coordination of zinc ions and its structural conformation along with the zinc coordination scheme were determined. however, the ordering of the histidine tag by zinc does not affect the overall structure of the rest of the pr ... | 2001 | 11264576 |
| maternal periodontitis and prematurity. part ii: maternal infection and fetal exposure. | clinical data from the first 812 deliveries from a cohort study of pregnant mothers entitled oral conditions and pregnancy (ocap) demonstrate that both antepartum maternal periodontal disease and incidence/progression of periodontal disease are associated with preterm birth and growth restriction after adjusting for traditional obstetric risk factors. in the current study we present measures of maternal periodontal infection using whole chromosomal dna probes to identify 15 periodontal organisms ... | 2001 | 11887461 |
| comparative in vitro activities of abt-773 against 362 clinical isolates of anaerobic bacteria. | the activity of abt-773, a novel ketolide antibiotic, against clinical isolates of anaerobic bacteria was determined and compared to the activities of other antimicrobial agents. mics at which 90% of isolates were inhibited (mic(90)s) were </=0.06 microg/ml for actinomyces spp., clostridium perfringens, peptostreptococcus spp., propionibacterium spp., and porphyromonas spp. the mic(50)s and mic(90)s were </=0.06 and >32 microg/ml, respectively, for eubacterium spp., lactobacillus spp., clostridi ... | 2001 | 11120995 |
| peptostreptococcus asaccharolyticus renal abscess: a rare cause of fever of unknown origin. | renal abscess is uncommon in pediatrics and is rarely a cause of fever of unknown origin. we recently cared for a patient who presented with a 3-week history of fever. an indium scan ultimately led to the diagnosis of a renal abscess. aspiration yielded peptostreptococcus asaccharolyticus. this unusual case prompted a review of the clinical and microbiologic features of renal abscess in pediatric patients at our hospital over the past 10 years. seven additional patients with a discharge diagnosi ... | 2001 | 11134475 |
| studies on a single immunoglobulin-binding domain of protein l from peptostreptococcus magnus: the role of tyrosine-53 in the reaction with human igg. | chemical modification experiments with tetranitromethane (tnm) have been used to investigate the role of tyrosine residues in the formation of the complex between ppl (the single ig-binding domain of protein l, isolated from p. magnus strain 3316) and the kappa light chain (kappa-chain). reaction of ppl with tnm causes the modification of 1.9 equiv. of tyrosine (tyr(51) and tyr(53)) and results in an approx. 140-fold decrease in affinity for human igg. similar experiments with mutated ppl protei ... | 2001 | 11139405 |
| two cases of diskitis attributable to anaerobic bacteria in children. | diskitis, an inflammation of the intervertebral disk, is generally attributable to staphylococcus aureus and rarely staphylococcus epidermidis, kingella kingae, enterobacteriaciae, and streptococcus pneumoniae. in many cases, no bacterial growth is obtained from infected intervertebral discs. although anaerobic bacteria were recovered from adults with spondylodiscitis, these organisms were not reported before from children. the recovery of anaerobic bacteria in 2 children with diskitis is report ... | 2001 | 11158500 |
| macrolide resistance in peptostreptococcus spp. mediated by ermtr: possible source of macrolide-lincosamide-streptogramin b resistance in streptococcus pyogenes. | eighty percent (21 of 26) of macrolide-resistant peptostreptococcus strains studied harbored the ermtr gene. this methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin b-resistant streptococcus pyogenes strains. transfer of the ermtr gene from peptostreptococcus magnus to macrolide-susceptible s. pyogenes strains indicates that this resistance determinant may circulate among gram-positive aerobic and anaerobic species of the oropharyngeal bacteri ... | 2001 | 11158770 |
| interleukin-6 deficiency increases inflammatory bone destruction. | periapical bone destruction occurs as a consequence of pulpal infection. in previous studies, we showed that interleukin-1 (il-1) is the primary stimulator of bone destruction in this model. il-6 is a pleiotropic cytokine that is induced in these infections and has both pro- and anti-inflammatory activities. in the present study, we determined the role of il-6 in regulating il-1 expression and bone resorption. the first molars of il-6 knockouts (il-6(-/-)) and wild-type mice were subjected to su ... | 2001 | 11159963 |
| immunoglobulin-binding domains of peptostreptococcal protein l enhance vaginal colonization of mice by streptococcus gordonii. | protein l, an immunoglobulin-binding protein of some strains of the anaerobic bacterium peptostreptococcus magnus, has been hypothesized to be a virulence determinant in bacterial vaginosis. in order to investigate the role of protein l in peptostreptococcal virulence, the ig-binding domains of protein l were expressed at the surface of the human oral commensal streptococcus gordonii. recombinant streptococci were used in vaginal colonization experiments, and protein l-expressing s. gordonii dem ... | 2001 | 11312616 |
| amoxicillin plus metronidazole in the treatment of adult periodontitis patients. a double-blind placebo-controlled study. | the aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement. | 2001 | 11314884 |
| [cellulitis and necrotizing fasciitis: microbiology and pathogenesis]. | streptococcus pyogenes is a common cause of necrotizing cutaneous infections in otherwise healthy children and adults. several surface components are involved in the processes of adherence and invasiveness, such as protein m and capsulae. streptolysin o and other bacterial products, such as pyrogenic exotoxins, are involved in tissue injury and necrosis. toxins a and c act as superantigens and are expressed by strains associated with the toxic shock syndrome. staphylococcus aureus, alone or in a ... | 2001 | 11319369 |
| linezolid: a review of its use in the management of serious gram-positive infections. | linezolid is the first of a new class of antibacterial drugs, the oxazolidinones. it has inhibitory activity against a broad range of gram-positive bacteria, including methicillin-resistant staphylococcus aureus (mrsa), glycopeptide-intermediate s. aureus (gisa), vancomycin-resistant enterococci (vre) and penicillin-resistant streptococcus pneumoniae. the drug also shows activity against certain anaerobes, including clostridium perfringens, c. difficile, peptostreptococcus spp. and bacteroidesfr ... | 2001 | 11324682 |
| a microbiological study of papillon-lefévre syndrome in two patients. | to analyse the microflora of subgingival plaque from patients with papillon-lefévre syndrome (pls), which is a very rare disease characterised by palmar-plantar hyperkeratosis with precocious periodontal destruction. | 2001 | 11328836 |
| bacteria isolated after unsuccessful endodontic treatment in a north american population. | the purpose of this study was to determine the composition of the microbial flora present in teeth after the failure of root canal therapy in a north american population. these results were then compared with those of the previous scandinavian studies. | 2001 | 11346739 |
| relationship of cigarette smoking to the subgingival microbiota. | the relationship of cigarette smoking to the composition of the subgingival microbiota is not clear. some studies indicated higher levels of certain species in smokers, while other studies failed to detect differences in the microbiota between subjects with different smoking histories. thus, the purpose of the present investigation was to examine the prevalence, proportions and levels of the subgingival species in adult subjects who were current, past or never smokers. | 2001 | 11350499 |
| comparative in vitro activities of gemifloxacin, other quinolones, and nonquinolone antimicrobials against obligately anaerobic bacteria. | the in vitro activity of gemifloxacin was compared to that of other quinolone and nonquinolone antimicrobials against 204 anaerobes by the agar dilution technique. the data indicate that gemifloxacin has a rather selective anaerobic activity. most peptostreptococcus, porphyromonas, and fusobacterium species are susceptible, while gemifloxacin's activity against other gram-negative anaerobes appears to be variable. | 2001 | 11353648 |
| vaginal microflora associated with bacterial vaginosis in nonpregnant women: reliability of sialidase detection. | to determine the prevalence of gardnerella vaginalis, anaerobic bacteria and mycoplasma hominis in vaginal specimens of women with and without bacterial vaginosis (bv) as well as to determine the sensitivity and specificity of the direct sialidase assay of vaginal fluid as a rapid test for diagnosing this syndrome. | 2001 | 11368254 |
| recovery of anaerobic bacteria from 3 patients with infection at a pierced body site. | we describe 3 adolescents who developed infections due to anaerobes at pierced body sites: the nipple, the umbilicus, and the nasal septum. anaerobes (prevotella intermedia and peptostreptococcus anaerobius) were recovered from pure culture of specimens obtained from 1 patient with nipple infection and were mixed with aerobic bacteria in cultures of specimens obtained from 2 patients (streptococcus aureus, peptostreptococcus micros, and prevotella melaninogenica were recovered from a patient wit ... | 2001 | 11389513 |
| smoking affects the subgingival microflora in periodontitis. | tobacco smoking has been identified as one major risk factor for destructive periodontal disease. scaling and root planing have been shown to be less effective in smokers with periodontitis. the aim of the present study was to compare the subgingival microbial flora of treated and untreated smokers and non-smokers. | 2001 | 11394403 |
| in vitro activity and post-antibiotic effect of quinupristin/dalfopristin (synercid). | the in vitro activities of quinupristin/dalfopristin (synercid), ampicillin, erythromycin, clarithromycin, vancomycin, teicoplanin, ciprofloxacin and tetracycline were examined and compared against 526 gram-positive bacteria. the minimal inhibitory concentrations (mics) for quinupristin/dalfopristin against staphylococcus aureus, including methicillin-resistant strains, were low (mic(90) = 0.5 mg/l), and were comparable with those of vancomycin and teicoplanin. this compound was superior to the ... | 2001 | 11399860 |
| [pharmacological and pharmacokinetic properties of azithromycin (zithromac), a novel 15-membered ring macrolide antibacterial agent]. | azithromycin (zithromac), a 15-membered ring macrolide antibacterial agent, was approved to be manufactured in japan in march 2000. it showed good in vitro and/or in vivo antibacterial activities against staphylococcus aureus, streptococcus pneumoniae, streptococcus pyogenes, peptostreptococcus micros, haemophilus influenzae, moraxella catarrhalis, mycoplasma pneumoniae and chlamydia pneumoniae. its activity against h. influenzae was particularly more potent than that of currently used macrolide ... | 2001 | 11411344 |
| role of aromatic stacking interactions in the modulation of the two-electron reduction potentials of flavin and substrate/product in megasphaera elsdenii short-chain acyl-coenzyme a dehydrogenase. | the effects of aromatic stacking interactions on the stabilization of reduced flavin adenine dinucleotide (fad) and substrate/product have been investigated in short-chain acyl-coenzyme a dehydrogenase (scad) from megasphaera elsdenii. mutations were made at the aromatic residues phe160 and tyr366, which flank either face of the noncovalently bound flavin cofactor. the electrochemical properties of the mutants were then measured in the presence and absence of a butyryl-coa/crotonyl-coa mixture. ... | 2001 | 11412126 |
| microbiological characteristics of subgingival microbiota in adult periodontitis, localized juvenile periodontitis and rapidly progressive periodontitis subjects. | to describe the prevalence of the cultivable subgingival microbiota in periodontal diseases and to draw attention to the polymicrobial nature of periodontic infections. | 2001 | 11422244 |
| untreated periodontal disease in indonesian adolescents. subgingival microbiota in relation to experienced progression of periodontitis. | in an indonesian population deprived of regular dental care, the experienced progression of disease between baseline (1987) and follow-up (1994) was investigated in relation to the composition of the subgingival microbiota at follow-up. at baseline the age ranged from 15 to 25 years. clinical and microbiological evaluation was completed in 158 of the 167 subjects available at follow-up. | 2001 | 11422582 |
| mutans streptococci in subgingival plaque of treated and untreated patients with periodontitis. | the etiology of root caries is thought to be identical to coronal caries, though root caries seem to be more complicated because of the higher susceptibility of exposed roots (dentin) by periodontal therapy to demineralization than intact enamel. this implies that mutans streptococci are the most likely pathogens in the development of root caries. although it is known that both the numbers of mutans streptococci and the frequency of isolation in root caries lesions are negatively correlated with ... | 2001 | 11422591 |
| computer-based redesign of a protein folding pathway. | a fundamental test of our current understanding of protein folding is to rationally redesign protein folding pathways. we use a computer-based design strategy to switch the folding pathway of protein g, which normally involves formation of the second, but not the first, beta-turn at the rate limiting step in folding. backbone conformations and amino acid sequences that maximize the interaction density in the first beta-hairpin were identified, and two variants containing 11 amino acid replacemen ... | 2001 | 11427890 |
| cavernous sinus thrombophlebitis caused by sphenoid sinusitis--report of autopsy case. | a 34-year-old man developed fever, headache, nausea, double vision, exophthalmus, ptosis, disturbance of vision and oculomotor nerve palsy. magnetic resonance imaging and cerebral angiography led to the clinical diagnoses of cavernous sinus thrombophlebitis and suspicion of bacterial aneurysm of the left internal carotid artery, respectively. peptostreptococcus was detected in blood culture analysis. he died 15 days after admission. systemic organs showed several septic changes. in particular, t ... | 2001 | 11430492 |
| nugent score related to vaginal culture in pregnant women. | to relate gram-stained smears, using the nugent criteria, to quantitative and qualitative vaginal cultures in pregnant women. | 2001 | 11430961 |
| recovery of anaerobic bacteria from four children with postthoracotomy sternal wound infection. | the cases of 4 children who developed postthoracotomy sternal wound infection caused by anaerobic bacteria are presented. the predominate anaerobes were peptostreptococcus species and pigmented prevotella species. polymicrobial infection was present in all cases, and aerobic bacteria also were recovered in 2 instances. all patients responded to surgical debridement and antimicrobials effective against the isolated aerobic and anaerobic bacteria. these findings highlight the potential importance ... | 2001 | 11433096 |
| chi1 torsion angle dynamics in proteins from dipolar couplings. | experiments are presented for the measurement of one-bond carbon-proton dipolar coupling values at ch and ch2 ositions in 13c-labeled, approximately 50% fractionally deuterated proteins. 13cbeta-1hbeta dipolar couplings have been measured for 38 of 49 possible residues in the 63-amino-acid b1 domain of peptostreptococcal protein l in two aligning media and interpreted in the context of side-chain chi1 torsion angle dynamics. the beta protons for 18 of the 25 beta-methylene-containing amino acids ... | 2001 | 11448195 |
| antibacterial activity and post-antibiotic effect of flurithromycin compared with other macrolides and penicillins against periodontal pathogens. | in this study the authors examined the activity of flurithromycin compared to that of erythromycin, spiramycin and penicillin against 107 strains of various species supposed to cause periodontitis. the range of mics of flurithromycin was: < or =0.06-2 mg/l for p. gingivalis (28 isolates), 0.06-2 mg/l for p. melaninogenica (7), 0.5-4 mg/l for p. intermedia (5), 0.25-8 mg/l for prevotella sp. (8), 1-16 mg/l for f. nucleatum (14), 0.12-0.5 mg/l for w. recta (2), 0.5-32 mg/l for e. corrodens, 0.5-2 ... | 2001 | 11450882 |
| bacteriology and beta-lactamase activity in acute exacerbation of chronic bronchitis. | to assess the bacteriology of beta-lactamase (bl) enzyme activity in sputum of 40 patients with acute exacerbation of chronic bronchitis (aecb). | 2001 | 11468101 |
| [bacteriologic investigation of periodontal infections]. | the gingivitis and periodontitis are very common diseases in hungary: more than 80% of the adult population suffers with gingivitis and 15-20% has destructive periodontitis. the composition of peridontopathogenic bacterial flora is totally different from that of the bacterial flora causing dental infections. in periodontal infections dominantly facultative and obligatory anaerobic microorganisms occur (actinobacillus actinomycetemcomitans (a. actinomycetemcomitans), porphyromonas gingivalis (p. ... | 2001 | 11480243 |
| effect of amoxycillin with or without clavulanate on adenoid bacterial flora. | the effect of antimicrobial therapy with amoxycillin (amx) or co-amoxiclav (amc) on the adenoid bacterial flora of 45 children with recurrent otitis media (rom), scheduled for elective adenoidectomy, was studied. patients were randomized before surgery into three groups of 15, having had either no antibiotic therapy (control), or 10 days of therapy with amx or amc. core adenoid tissues were quantitatively cultured for aerobic and anaerobic bacteria. polymicrobial aerobic-anaerobic flora was pres ... | 2001 | 11481299 |
| an in vitro evaluation of the antimicrobial efficacy of irrigants on biofilms of root canal isolates. | the bactericidal effect of four antimicrobial agents was investigated against single-species biofilms derived from a range of root canal isolates. | 2001 | 11482142 |