Publications

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severe self-poisoning--a ten year experience in the glasgow area. 20154428207
letter: cervical incompetence. 20154419859
[side effects of antibiotics, measures of prevention and treatment]. 20154487226
[genuine pancreatic cyst in a 6-week-old infant]. 20154438214
[a new theory upon electrocardiogram origin. ii (author's transl)]. 20154430393
[discovery of chagasia rozeboomi causey, deane & deane 1944 in the state of sao paulo]. 20154385471
[the value of conventional radiographic methods in the differential diagnosis of congenital cardiac defects during the first month of life (author's transl)]. 20154364486
[combined corticosteroid and synthetic depot acth therapy in chronic obstructive ventilation disorders]. 20154364059
a preliminary report on complex fibrillar aggregates in the gill epithelium of panulirus interruptus (randall). 20154372749
[long term results of transtemporal neurectomy of the vestibular nerve in menière's disease (author's transl)]. 20154420512
spin concentration per living cell of normal liver, regenerating liver, and hepatomas. 20154363447
pituitary hormones: international colloquium. 20154303024
characterization of soluble, fsf-stabilized fibrin complexes with special reference to the role of fibrinogen. 20154428469
supranuclear paralysis of voluntary lid closure. 20155053249
supranuclear paralysis of voluntary lid closure. 20155053249
synthetic protein-sugar conjugates as models for the complement-inactivating property of atopic allergens. 20154468870
stereochemical aspects of antihistamine action. 4. absolute configuration of carbinoxamine antipodes. 20154400865
[urgency in the repair of retinal detachment (author's transl)]. 20154437016
[bedside nursing. change of posture and early ambulation following abdominal surgery]. 20154632701
[contribution to the knowledge of eye injuries caused by the tear gas - chloracetophenone]. 20154620191
[busulfan-induced adrenal insufficiency]. 20154520013
doxepine therapy in outpatients with depressive anxious states. 20154471595
[investigations on the polymorphism of red cell esterase d by high voltage agarose gel electrophoresis (author's transl)]. 20154450806
demonstration of a vesicocolonic fistula during a bone scan. a case report. 20154422582
an adrenergic control system in tetrahymena. 20154382515
massive pulmonary embolism. 20154699205
a physician's letter written in 1772 suggesting treatment for his ailing infant nephew. 20154871649
a physician's letter written in 1772 suggesting treatment for his ailing infant nephew. 20154871649
injuries to the neck and upper extremity in sports. 20154806587
[significance of biochemical indices of cadaver blood in pathologico-anatomic diagnosis]. 20154770202
[significance of biochemical indices of cadaver blood in pathologico-anatomic diagnosis]. 20154770202
[doctor françois a. hubert larue, physician and essayist]. 20154574736
paul wood revisited. selected articles and commentary from paul wood's bibliography. 20154558922
[complex diagnosis of osteogenic sarcoma]. 20154528172
activation of peripheral t cells of sarcoidosis patients and healthy controls. 20154549733
[the capillary electrode porarization by the positive and negative current (author's transl)]. 20154523942
nursing and some large moral issues. 20154496569
[clinical aspects, course and therapy of disseminated encephalomyelitis in chronic acquired toxoplasmosis]. 20154466244
[light and electron microscopy studies of hydrargyrosis and argyrosis of the skin]. 20154443252
[electric resistance of blood and urine in diabetic ketoacidosis in children]. 20154632489
abdominal lymphoma with malabsorption. 20154407962
[reagent strip methods to evaluate ketosis. administration and possible errors]. 20154763879
[mounier-kuhn syndrome (tracheobronchomegaly)]. 20154547889
the cardiovascular and respiratory effects of isoflurane-nitrous oxide anaesthesia. 20154462956
the serine protease autotransporter pic modulates citrobacter rodentium pathogenesis and its innate recognition by the host.bacterial pathogens produce a number of autotransporters that possess diverse functions. these include the family of serine protease autotransporters of enterobacteriaceae (spates) produced by enteric pathogens such as shigella flexneri and enteroaggregative escherichia coli. of these spates, one termed "protein involved in colonization," or pic, has been shown to possess mucinase activity in vitro, but to date, its role in in vivo enteric pathogenesis is unknown. testing a pic null (δpicc) muta ...201525895966
in vivo production of a novel glycoconjugate vaccine against shigella flexneri 2a in recombinant escherichia coli: identification of stimulating factors for in vivo glycosylation.glycoconjugated vaccines composed of polysaccharide antigens covalently linked to immunogenic carrier proteins have proved to belong to the most effective and safest vaccines for combating bacterial pathogens. the functional transfer of the n-glycosylation machinery from campylobacter jejuni to the standard prokaryotic host escherichia coli established a novel bioconjugation methodology termed bacterial glycoengineering.201525612741
visualization of the type iii secretion sorting platform of shigella flexneri.bacterial type iii secretion machines are widely used to inject virulence proteins into eukaryotic host cells. these secretion machines are evolutionarily related to bacterial flagella and consist of a large cytoplasmic complex, a transmembrane basal body, and an extracellular needle. the cytoplasmic complex forms a sorting platform essential for effector selection and needle assembly, but it remains largely uncharacterized. here we use high-throughput cryoelectron tomography (cryo-et) to visual ...201525583506
[pharmacological studies on chemical protectors against radiation. 8. radioprotective activities of cysteamine and its related compounds]. 20154736442
[pharmacological studies on chemical protectors against radiation. 8. radioprotective activities of cysteamine and its related compounds]. 20154736442
axillary-axillary bypass for the "subclavian steal" syndrome. 20154682100
[state of the blood coagulation and anticoagulation systems in gallbladder and biliary tract diseases in children]. 20154658334
[surgery of interauricular communication in patients over 40 years of age]. 20154712784
freidenwald lecture, 1974: introduction of mathew alpern, ph.d. 20154604493
[methods for the identification of mathematical models of dynamic processes in biological systems]. 20154678813
proton conductance of cell membranes. 20154741705
soft-tissue injury by mercury from a broken thermometer. a case report and review of the literature. 20154590643
[q beta rna replicase]. 20154567707
postgraduate education in public health at the nordic school of public health. 20154536488
congenital dislocation of the hip joint in norway. iii. neonatal cdh. 20154530601
hereditary fleck dystrophy associated with decreased corneal sensitivity. 20154537353
[treatment of diseases of permanent teeth with unformed roots. 2. treatment of diseases of the pulp]. 20154508803
[activity of leucocyte alkaline phosphatase in girls aged 7-15 years]. 20154641007
[2 misleading forms of acute perforated appendicitis in young infants: association with acute intestinal invagination: presentation simulating an acute orchitis syndrome]. 20154543651
[prognosis in leprosy]. 20154480378
[radioimmunological determination of parathormone in chronic renal failure]. 20154820156
"and then there were none". 20154485126
[experimental study on postexodontic wound healing with special reference to the use of dental cones of a combination of neomyson and lysozyme]. 20154549827
2,3-diphosphoglycerate concentrations and the dissociation of oxyhaemoglobin in ventilatory failure. 20154448040
association between hypokaliaemic alkalosis and development of arrhythmia in early postoperative period. 20154447254
[immunoglobulins in the cervico-vaginal content of clinically normal women and of women with trichomonas, candida or bacterial infections]. 20154425180
development of temporomandibular joint innervation. 20154529279
the toxicity of 2,3,7,8-tetrachlorodilbenzo-p-dioxin (tcdd) in guppies (poecilia reticulatus peters). 20154433855
a transplantable pregnancy-dependent mammary tumor line (tpdmt-4) in strain ddd mice. 20154426477
[drug permeation through synthetic lipid membranes. permeability of lecithin-collodium membranes for drugs and metabolites]. 20154420510
proceedings: effect of synthetic corticotrophin analogues on plasma delta4-androstenedione, testosterone and gonadotrophins in normal men. 20154364188
an internal auditing system for improving the quality of medical care. 20154363405
[therapy of bronchial asthma]. 20154372025
[reflection of the establishment of soviet public health in the graphic arts]. 20154885213
prolongation of a pancuronium-induced neuronmuscular blockade by polymyxin b. 20154359101
identification and molecular characterisation of a novel mu-like bacteriophage, sfmu, of shigella flexneri.s. flexneri is the leading cause of bacillary dysentery in the developing countries. several temperate phages originating from this host have been characterised. however, all s. flexneri phages known to date are lambdoid phages, which have the ability to confer the o-antigen modification of their host. in this study, we report the isolation and characterisation of a novel mu-like phage from a serotype 4a strain of s. flexneri. the genome of phage sfmu is composed of 37,146 bp and is predicted to ...201525902138
characterisation of shigella spa33 and thermotoga flim/n reveals a new model for c-ring assembly in t3ss.flagellar type iii secretion systems (t3ss) contain an essential cytoplasmic-ring (c-ring) largely composed of two proteins flim and flin, whereas an analogous substructure for the closely related non-flagellar (nf) t3ss has not been observed in situ. we show that the spa33 gene encoding the putative nf-t3ss c-ring component in shigella flexneri is alternatively translated to produce both full-length (spa33-fl) and a short variant (spa33-c), with both required for secretion. they associate in a ...201526538516
in vitro antibacterial, antioxidant activity and total phenolic content of some essential oils.in vitro antibacterial activity of 16 essential oils was investigated by disc diffusion method against two gram positive bacteria bacillus subtilis and staphylococcus aureus and two gram negative bacteria, shigella flexneri and escherichia coli. oils of cymbopogon citratus and ocimum basilicum showed highest antibacterial activity. gram positive bacteria were found to be more sensitive than gram negative. antioxidant activities were tested by 2,2-diphenyl-1-picrylhydrazyl (dpph) radical scavengi ...201526688969
antibacterial mode of action of the hydroethanolic extract of leonotis nepetifolia (l.) r. br. involves bacterial membrane perturbations.leonotis nepetifolia (l) r. br., lamiaceae, a pantropical shrub, popularly known in brazil as "cordão-de-frade", "rubim", is reportedly used in brazilian ethnomedicine as well as in different countries in the treatments of ailments such as infections, inflammations, wounds, stomach disorders, among others.201526102550
antimicrobial evaluation of plants used for the treatment of diarrhoea in a rural community in northern maputaland, kwazulu-natal, south africa.zulu people living in the rural area of maputaland (kwazulu-natal, south africa) rely heavily on medicinal plants for the treatment of diarrhoea. abundant availability of medicinal plants in the study area offers low cost health care, but scientific validation is needed in order to lend credibility to the traditional use against many ailments including diarrhoeal infections. with this in mind a study was designed to test the in vitro antimicrobial efficacy of 23 plant species which are used for ...201525881066
antibacterial activity of ovary extract from sea urchin diadema setosum.sea urchin gonad is considered as a highly prized delicacy in several countries. it is also rich in valuable bioactive compounds including polyunsaturated fatty acids (pufas) and β-carotene. this study was undertaken to examine the antimicrobial properties of the ovary extract from sea urchin diadema setosum against selected gram-negative and gram-positive bacteria.201526044237
report: antibacterial and antifungal activities of leaf extract of achyranthes aspera (amaranthaceae) from pakistan.alcoholic extract and various fractions of achyranthes aspera leaves, traditionally used in pakistan for treatment of infectious diseases was screened for in vitro antibacterial and antifungal activity. the chloroform and butanol fractions were found to be the most active among the fractions, showing considerable antibacterial activity against shigella flexneri and escherichia coli. the highest activity was found in the ethylacetate fraction (17 mm zone of inhibition) against gram-negative (salm ...201526408900
material properties and antimicrobial activity of polyhydroxybutyrate (phb) films incorporated with vanillin.polyhydroxybutyrate (phb) was produced by bacillus mycoides dfc 1, isolated from garden soil. antimicrobial (am) films of phb were prepared by incorporating vanillin (4-hydroxy-3-methoxybenzaldehyde) from 10 to 200 μg/g of phb. the films were assessed for antimicrobial activity against foodborne pathogens and spoilage bacteria comprising of escherichia coli, salmonella typhimurium, shigella flexneri, and staphylococcus aureus and fungi such as aspergillus flavus, aspergillus fumigatus, aspergill ...201526002697
design, synthesis and in vitro bactericidal/fungicidal screening of some vanadyl(iv)complexes with mono- and di-substituted ons donor triazoles.a new series of anti-bacterial and anti-fungal mono- and di-substituted triazoles (l(1))-(l(6)) have been synthesized and characterized on the basis of their physical, spectral and analytical data. the ligands (l(1))-(l(6)) on reaction with vanadyl(iv) sulphate led to the formation of vanadyl(iv) metal complexes (1)-(4). the structure of the complexes has been established on the basis of their physical, spectral and elemental analyses data. the synthesized ligands and their vanadyl(iv) complexes ...201525716124
1,1-diphenyl,2-picrylhydrazyl free radical scavenging, bactericidal, fungicidal and leishmanicidal properties of teucrium stocksianum.in the present study, we evaluated the pharmacological and toxicological effects of teucrium stocksianum. the crude extract of t. stocksianum (ts.cr) and its subsequent organic fractions: n-hexane (ts.hex), chloroform (ts.chcl3) and ethyl acetate (ts.etac) exhibited 1,1-diphenyl,2-picrylhydrazyl free radical scavenging activity with different potencies. ts.etac was found to be most potent. ts.cr, ts.hex, ts.chcl3 and ts.etac showed significant bactericidal activity against escherichia coli, stap ...201523625908
structural and biochemical analysis of a single amino-acid mutant of wzzbsf that alters lipopolysaccharide o-antigen chain length in shigella flexneri.lipopolysaccharide (lps), a surface polymer of gram-negative bacteria, helps bacteria survive in different environments and acts as a virulence determinant of host infection. the o-antigen (oag) component of lps exhibits a modal chain-length distribution that is controlled by polysaccharide co-polymerases (pcps). the molecular basis of the regulation of oag chain-lengths remains unclear, despite extensive mutagenesis and structural studies of pcps from escherichia coli and shigella. here, we ide ...201526378781
broad spectrum antimicrobial compounds from the bacterium exiguobacterium mexicanum mssrfs9.clinical bacterial pathogens front a major challenge for the clinical researchers and physicians. in particular microbial pathogens like escherichia coli, shigella flexneri, klebsiella pneumonia and salmonella enterica are apparelled with systemic machineries to bring down the human immune system as well as proliferate dramatically in a short period which in turn cause a pronounced ailment to the human health. in vitro evaluation of four purified compounds isolated from rhizosphere bacterium exi ...201526302848
species-wide whole genome sequencing reveals historical global spread and recent local persistence in shigella flexneri.shigella flexneri is the most common cause of bacterial dysentery in low-income countries. despite this, s. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. here we combine whole genome sequencing with geographical and temporal data to examine the natural history of the species. our analysis subdivides s. flexneri into seven phylogenetic groups (pgs); each containing two-or-mor ...201526238191
the effect of quorum sensing system for growth competitiveness on shigella flexneri.quorum sensing (qs) regulates the onset of bacterial social responses related to cell density. comparison between the gene sequences of all components of qs system of escherichia coli and shigella strains, shows that the qs system is generally lost or mutated in shigella. since ai-2 is produced and processed by the lsr operon, we analyzed the potential function of the lsr operon. we first detected ai-2 in shigella flexneri 2a strain 301 through the reporter bacteria vibrio harveyi bb170, indicat ...201525998438
prevalence of shiga toxin-producing shigella species isolated from french travellers returning from the caribbean: an emerging pathogen with international implications.shiga toxins (stxs) are potent cytotoxins that inhibit host cell protein synthesis, leading to cell death. classically, these toxins are associated with intestinal infections due to stx-producing escherichia coli or shigella dysenteriae serotype 1, and infections with these strains can lead to haemolytic-uraemic syndrome. over the past decade, there has been increasing recognition that stx is produced by additional shigella species. we recently reported the presence and expression of stx genes i ...201525980352
engineering escherichia coli into a protein delivery system for mammalian cells.many gram-negative pathogens encode type 3 secretion systems, sophisticated nanomachines that deliver proteins directly into the cytoplasm of mammalian cells. these systems present attractive opportunities for therapeutic protein delivery applications; however, their utility has been limited by their inherent pathogenicity. here, we report the reengineering of a laboratory strain of escherichia coli with a tunable type 3 secretion system that can efficiently deliver heterologous proteins into ma ...201525853840
formate hydrogen lyase mediates stationary-phase deacidification and increases survival during sugar fermentation in acetoin-producing enterobacteria.two fermentation types exist in the enterobacteriaceae family. mixed-acid fermenters produce substantial amounts of lactate, formate, acetate, and succinate, resulting in lethal medium acidification. on the other hand, 2,3-butanediol fermenters switch to the production of the neutral compounds acetoin and 2,3-butanediol and even deacidify the environment after an initial acidification phase, thereby avoiding cell death. we equipped three mixed-acid fermenters (salmonella typhimurium, s. enteriti ...201525762991
crystal structure of lpth, the periplasmic component of the lipopolysaccharide transport machinery from pseudomonas aeruginosa.lipopolysaccharide (lps) is the main glycolipid present in the outer leaflet of the outer membrane (om) of gram-negative bacteria, where it modulates om permeability, therefore preventing many toxic compounds from entering the cell. lps biogenesis is an essential process in gram-negative bacteria and thus is an ideal target pathway for the development of novel specific antimicrobials. the lipopolysaccharide transport (lpt) system is responsible for transporting lps from the periplasmic surface o ...201525735820
first two domains at the lp_1643 protein n terminus inhibit pathogen adhesion to porcine mucus in vitro.gastrointestinal probiotics are important members of intestinal microflora in both healthy animals and human beings, and these bacteria may reduce the risk of infection caused by certain opportunistic pathogens through exclusive inhibition, competition, and displacement. the lp_1643 protein on the cell surface of lactobacillus plantarum wcfsi was assumed to possess a mucus-binding capability. this study aimed to determine if purified his-n2 protein exclusively inhibits pathogen adhesion to porci ...201525710153
distribution and antimicrobial resistance of enteric pathogens in chinese paediatric diarrhoea: a multicentre retrospective study, 2008-2013.the enteric pathogens causing diarrhoea impair children's health severely. this study retrospectively analysed 1577 pathogens isolated from inpatients and outpatients in six hospitals located in northern (inner mongolia), northeastern (hebei), eastern (shanghai and jiangsu), southern (hainan) and central (hubei) china between 2008 and 2013. of the 1577 enteric pathogens, salmonella presented with the highest frequency (36·0%), followed by diarrhoeagenic escherichia coli (23·7%), staphylococcus a ...201525586929
the serine protease pic from enteroaggregative escherichia coli mediates immune evasion by the direct cleavage of complement proteins.enteroaggregative and uropathogenic escherichia coli, shigella flexneri 2a, and the hybrid enteroaggregative/shiga toxin-producing e. coli strain (o104:h4) are important pathogens responsible for intestinal and urinary tract infections, as well as sepsis and hemolytic uremic syndrome. they have in common the production of a serine protease called pic. several biological roles for pic have been described, including protection of e. coli dh5α from complement-mediated killing. hereby we showed that ...201525583166
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