Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [upper endoscopy findings in obese morbid patients candidates for bariatric surgery]. | body mass index has been associated with the presence and severity of various gastrointestinal symptoms. the aim of the study was to analyze the endoscopic findings and gastric histology of morbidly obese candidates for bariatric surgery. | 2017 | 25709107 |
| helicobacter pylori: a common infection. | 2017 | 25657976 | |
| advances in the treatment of helicobacter pylori infection in children. | in this review we elaborate on two main questions concerning the management of helicobacter pylori infection in children. first, we focus on who should be treated. in the presence of helicobacter pylori (h. pylori)-associated peptic ulcer disease, eradication of the micro-organism is recommended. when h. pylori infection is detected by biopsy-based methods in the absence of peptic ulcer disease in a child with dyspeptic symptoms, treatment of h. pylori infection may be considered. in infected ch ... | 2017 | 25608573 |
| [diet and gastric cancer in mexico and in the world]. | gastric cancer (gc) is the fourth leading cause of cancer death at global level. diet, alcohol and tobacco, in addition to helicobacter pylori infection, account for a large number of cases. some substances contained in foods may influence gc carcinogenesis process; however, the underlying mechanisms have not been fully elucidated. in mexico and worldwide, a low intake of fruits, non-starchy and allium vegetables, pulses, and foods containing selenium, as well as high intake of salt, salty, salt ... | 2017 | 25604301 |
| helicobacter pylori infection and gastroesophageal reflux disease - barrett's esophagus sequence "dilemma" | 2017 | 25608930 | |
| sequential therapy or standard triple therapy for helicobacter pylori infection: an updated systematic review. | the effectiveness of standard triple therapy (stt) for the eradication of helicobacter pylori has decreased recently. sequential therapy (sqt) is a new regimen proposed to address this problem. the aim of this study was to compare the efficacy of sqt versus stt for h. pylori eradication. we searched the cochrane library, medline, web of science, and embase databases up to july 2014. the risk ratios (rrs) of eradication rate were pooled, with a 95% confidence interval (ci). thirty-six randomized ... | 2017 | 25569598 |
| presentation and management of perforated peptic ulcer disease in a tertiary centre in south south nigeria. | perforations of the stomach and duodenum are common complications of peptic ulcer disease (pud), abuse of non steroidal anti inflammatory drugs (nsaids) and gastric cancer. being a life threatening complication of pud, it needs special attention with prompt resuscitation and appropriate surgical management if morbidity and mortality are to be avoided. | 2017 | 27830132 |
| clarithromycin-induced torsades de pointes. | acquired qt prolongation can be caused by cardiac and noncardiac medications. macrolides are known to prolong qt interval. rarely, it can be fatal. we report a case of torsades de pointes in a patient taking clarithromycin as a part of helicobacter pylori eradication regimen. | 2017 | 25057773 |
| epidemiology and pattern of antibiotic resistance in helicobacter pylori: scenario from saudi arabia. | helicobacter pylori is recognized as a major cause of gastritis, peptic ulcer, gastric cancer, and mucosa-associated lymphoma. infection with this gram-negative microaerophile has been treated using combination of antibiotics and proton pump inhibitors for different gastrointestinal diseases. the most commonly used treatment is triple therapy which consists of administration of a proton pump inhibitor, clarithromycin, and amoxicillin. many factors contribute to treatment failure, but one of the ... | 2017 | 25038206 |
| when coke is not hydrating: cocaine-induced acute interstitial nephritis. | a 47-year-old african american man was admitted with 4 days of back pain, nausea and vomiting, and low urine output. there was no history of fever, dysuria, frequency, hesitancy, viral symptoms, trauma, rash, or constipation. despite his past medical history of hypertension, diabetes mellitus, and hyperlipidemia he denied taking any medications for 18 months, including nonsteroidal anti-inflammatory drugs, acetaminophen, or antacids. he denied smoking and alcohol but admitted to cocaine use. no ... | 2017 | 26425622 |
| microbiome in reflux disorders and esophageal adenocarcinoma. | the incidence of esophageal adenocarcinoma has increased dramatically in the united states and europe since the 1970s without apparent cause. although specific host factors can affect risk of disease, such a rapid increase in incidence must be predominantly environmental. in the stomach, infection with helicobacter pylori has been linked to chronic atrophic gastritis, an inflammatory precursor of gastric adenocarcinoma. however, the role of h. pylori in the development of esophageal adenocarcino ... | 2017 | 24855009 |
| resistance to amoxicillin, clarithromycin and ciprofloxacin of helicobacter pylori isolated from southern brazil patients. | helicobacter pylori is a bacteria which infects half the world population and is an important cause of gastric cancer. the eradication therapy is not always effective because resistance to antimicrobials may occur. the aim of this study was to determine the susceptibility profile of h. pylori to amoxicillin, clarithromycin and ciprofloxacin in the population of southern brazil. | 2017 | 24878996 |
| novel insights on the role of cd8+ t cells and cytotoxic responses during helicobacter pylori infection. | helicobacter pylori chronically persists in 50% of the human population and causes serious gastric and duodenal pathologies in 15% of infected people. research on the immune response to the infection has mainly focused on the induction of cd4+ t cell responses. human studies emphasize the potential clinical relevance of cd8+ cytotoxic t lymphocytes, however this cell type has barely been reported in studies employing mouse or gerbil models. traditionally characterized as an extracellular bacteri ... | 2017 | 24755940 |
| effect of helicobacter pylori and its virulence factors on portal hypertensive gastropathy and interleukin (il)-8, il-10, and tumor necrosis factor-alpha levels. | we aimed to assess the influence of helicobacter pylori and its virulent factors, cytotoxin associated gene (cag) a and e, on portal hypertensive gastropathy (phg) and the levels of interleukin (il)-8, il-10, and tumor necrosis factor-alpha (tnf-α). | 2017 | 24705150 |
| role of childhood infection in the sequelae of h. pylori disease. | the persistence of helicobacter pylori infection plays a fundamental role in the development of h. pylori-associated complications. since the majority of infected persons acquire the bacteria during early childhood, an examination of the immunobiology of h. pylori infection in children compared with that of adults may help identify host factors that contribute to persistent infection. therefore, we begin our review of the role of persistence in h. pylori disease with an assessment of the clinica ... | 2017 | 24275060 |
| vaccinating against helicobacter pylori in the developing world. | helicobacter pylori infects more than half the world's population and in developing nations the incidence can be over 90%. the morbidity and mortality associated with h. pylori-associated diseases including ulcers and gastric cancer therefore, disproportionately impact the developing world. mice have been used extensively to demonstrate the feasibility of developing a vaccine for h. pylori infection, and for testing antigens, routes of immunization, dose, and adjuvants. these successes however, ... | 2017 | 24253617 |
| reprogramming of gastric motility with "pulse therapy" (metoclopramide and erythromycin) in severe gastroparesis. | gastroparesis is a very common condition, however many times it becomes difficult to manage even after long-term treatment due to multiple etiologies or improper therapy. patients with severe gastroparesis are considered candidates for gastric electrical stimulants. the "pulse therapy" using metoclopramide and erythromycin to reprogram gastric motility can delay or even avoid the need for gastric electrical stimulants. this case report focuses on a patient with severe gastroparesis, who was cons ... | 2017 | 26664852 |
| helicobacter pylori hp(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates vegf-alpha and tgf-beta release by interacting with formyl-peptide receptors. | eosinophils participate in the immune response against helicobacter pylori, but little is known about their role in the gastritis associated to the infection. we recently demonstrated that the hp(2-20) peptide derived from h. pylori accelerates wound healing of gastric mucosa by interacting with n-formyl peptide receptors (fprs) expressed on gastric epithelial cells. the aim of the present study was to investigate whether eosinophils play a role in the repair of gastric mucosa tissue during h. p ... | 2017 | 24067461 |
| unintended consequences of helicobacter pylori infection in children in developing countries: iron deficiency, diarrhea, and growth retardation. | helicobacter pylori infection is predominantly acquired early in life. the prevalence of the infection in childhood is low in developed countries, whereas in developing countries most children are infected by 10 y of age. in poor resource settings, where malnutrition, parasitic/enteropathogen and h. pylori infection co-exist in young children, h. pylori might have potentially more diverse clinical outcomes. this paper reviews the impact of childhood h. pylori infection in developing countries th ... | 2017 | 23988829 |
| current recommendations for helicobacter pylori therapies in a world of evolving resistance. | occurrence of resistance, especially to clarithromycin, renders the standard triple therapy used to cure helicobacter pylori infection ineffective. this review presents the bacteriological and pharmacological basis for h. pylori therapy and the current recommendations. the third-line treatment must be based on clarithromycin susceptibility testing. if the bacteria are still susceptible, failure may come from problems of compliance, hyperacidity or high bacterial load which can be overcome. if th ... | 2017 | 23929066 |
| helicobacter pylori infection does not promote hepatocellular cancer in a transgenic mouse model of hepatitis c virus pathogenesis. | helicobacter pylori (h. pylori) and hepatitis c virus (hcv) infect millions of people and can induce cancer. we investigated if h. pylori infection promoted hcv-associated liver cancer. helicobacter-free c3b6f1 wild-type (wt) and c3b6f1-tg(alb1-hcvn)35sml (ht) male and female mice were orally inoculated with h. pylori ss1 or sterile media. mice were euthanized at ~12 mo postinoculation and samples were collected for analyses. there were no significant differences in hepatocellular tumor promotio ... | 2017 | 23929035 |
| biomarkers of helicobacter pylori-associated gastric cancer. | helicobacter pylori-associated gastric cancer is a major cause of morbidity and mortality worldwide, and is predicted to become even more common in developing countries as the population ages. since gastric cancer develops slowly over years to decades, and typically progresses though a series of well-defined histologic stages, cancer biomarkers have potential to identify asymptomatic individuals in whom surgery might be curative, or even those for whom antibiotics to eradicate h. pylori could pr ... | 2017 | 23851317 |
| chronic inflammation and oxidative stress: the smoking gun for helicobacter pylori-induced gastric cancer? | helicobacter pylori is the leading risk factor associated with gastric carcinogenesis. h. pylori leads to chronic inflammation because of the failure of the host to eradicate the infection. chronic inflammation leads to oxidative stress, deriving from immune cells and from within gastric epithelial cells. this is a main contributor to dna damage, apoptosis and neoplastic transformation. both pathogen and host factors directly contribute to oxidative stress, including h. pylori virulence factors, ... | 2017 | 23811829 |
| study of the cytoxin-associated gene a (caga gene) in helicobacter pylori using gastric biopsies of iraqi patients. | the helicobacter pylori caga gene is a major virulence factor that plays an important role in gastric pathologies. the size variation of caga gene, which is dependent on the 3' repeat region, contains one or more glu-pro-ile-tyr-ala (epiya) motifs and caga multimerization (cm) motifs. four segments flanking the epiya motifs, epiya -a, -b, -c, or -d, were reported to play a crucial role in the pathogenesis of h. pylori infection. the aim was to determine the roles of epiya segments and cm motifs ... | 2017 | 23481132 |
| polymorphism in the helicobacter pylori caga and vaca toxins and disease. | half of the world's population is infected with helicobacter pylori and approximately 20% of infected individuals develop overt clinical disease such as ulcers and stomach cancer. paradoxically, despite its classification as a class i carcinogen, h. pylori has been shown to be protective against development of asthma, allergy, and esophageal disease. given these conflicting roles for h. pylori, researchers are attempting to define the environmental, host, and pathogen interactions that ultimatel ... | 2017 | 23380646 |
| optimization of culture conditions to improve helicobacter pylori growth in ham's f-12 medium by response surface methodology. | helicobacter pylori is a gastroduodenal pathogen that colonizes the human stomach and is the causal agent of gastric diseases. from the clinical and epidemiological point of view, enhancing and improving the growth of this bacterium in liquid media is an important goal to achieve in order to allow the performance of accurate physiological studies. the aim of this work was to optimize three culture conditions that influence the growth of h. pylori in the defined medium ham s f-12 supplemented wit ... | 2017 | 23298481 |
| correlation of serology with morphological changes in gastric biopsy in helicobacter pylori infection and evaluation of immunohistochemistry for h. pylori identification. | helicobacter pylori is implicated in various gastroduodenal diseases and many tests are available for its detection. the present study attempted to document the morphological changes in the gastric mucosa induced by h. pylori colonization and correlate them with the severity of the infection. the study also compared various diagnostic tests and evaluated the different staining methods used for h. pylori detection, especially immunohistochemical identification. | 2017 | 23150022 |
| par1b takes the stage in the morphogenetic and motogenetic activity of helicobacter pylori caga oncoprotein. | helicobacter pylori caga oncoprotein is critically involved in gastric carcinogenesis. upon delivery into gastric epithelial cells via type iv secretion, caga induces an extremely elongated cell-shape known as the hummingbird phenotype, which is associated with massive changes in actin cytoskeleton and elevated motility. with the notion that the hummingbird phenotype reflects pathogenic/oncogenic activity of caga, many studies have focused on the mechanism through which caga induces the morpholo ... | 2017 | 23076215 |
| chronic idiophatic urticaria and helicobacter pylori: a specific pattern of gastritis and urticaria remission after helicobacter pylori eradication. | chronic urticaria (cu) is defined as the occurrence of spontaneous wheals for a duration of more than 6 weeks and is the most frequent skin disease, with prevalence ranging between 15 and 25%, and is a seriously disabling condition, with social isolation and mood changes causing a significant degree of dysfunction and quality of life impairment to many patients. the main clinical features of cu are the repeated occurrence of transient eruptions of pruritic wheals or patchy erythema on the skin t ... | 2017 | 23058028 |
| modeling temporal relationships in large scale clinical associations. | we describe an approach for modeling temporal relationships in a large scale association analysis of electronic health record data. the addition of temporal information can inform hypothesis generation and help to explain the relationships. we applied this approach on a dataset containing 41.2 million time-stamped international classification of diseases, ninth revision (icd-9) codes from 1.6 million patients. | 2017 | 23019240 |
| furazolidone-based therapies for helicobacter pylori infection: a pooled-data analysis. | furazolidone-based therapies are used in developing countries to cure helicobacter pylori infection due to its low cost. the low bacterial resistance toward furazolidone may render appealing the use of this drug even in developed countries. however, some relevant safety concerns do exist in using furazolidone. | 2017 | 22249086 |
| immunologic properties and therapeutic efficacy of a multivalent epitope-based vaccine against four helicobacter pylori adhesins (urease, lpp20, hpaa, and cagl) in mongolian gerbils. | therapeutic vaccination is a desirable alternative for controlling helicobacter pylori (h. pylori) infection. attachment to the gastric mucosa is the first step in establishing bacterial colonization, and adhesins, which are on the surface of h. pylori, play a pivotal role in binding to human gastric mucosa. | 2017 | 28851031 |
| associations of helicobacter pylori infection and peptic disease with diabetic mellitus: results from a large population-based study. | evidence is conflicting regarding the association between helicobacter pylori infection and diabetes mellitus. the study objective was to examine associations of h. pylori infection, gastric ulcers and duodenal ulcers, with diabetes mellitus. | 2017 | 28850590 |
| rosacea and helicobacter pylori: links and risks. | rosacea is a chronic skin disease characterized by facial erythema and telangiectasia. despite the fact that many hypotheses have been proposed, its etiology remains unknown. in the present review, the possible link and clinical significance of helicobacter pylori in the pathogenesis of rosacea are being sought. a pubmed and google scholar search was performed using the terms "rosacea", "h.pylori", "gastrointestinal disorders and h.pylori", "microorganisms and rosacea", "pathogenesis and treatme ... | 2017 | 28848358 |
| the usefulness of investigating the possible underlying conditions in rosacea. | the paper entitled "rosacea and demodicidosis with gain of function mutation in stat1″ by second et al.(1) is of indubitable interest and prompted us to make some observations. the authors described a patient with cutaneous and ocular rosacea that they related to demodicidosis since oral ivermectin improved the cutaneous lesions(1) . however, the authors did not demonstrate by skin scraping nor by standardized skin surface biopsy (sssb) an excessive number of demodex folliculorum (df) mites in t ... | 2017 | 28846817 |
| successful eradication of helicobacter pylori with a herbal medicine, goshuyuto (wu zhu yu tang), plus rabeprazole after failure of triplet therapy with vonoprazan: a report of three cases. | vonoprazan, a potassium-competitive acid blocker, is used as a substitute drug for conventional proton pump inhibitors. recently, vonoprazan has been applied for eradication of h. pylori (hp) infection, and the efficacies of vonoprazan-based triple therapy against hp infection have already been reported. however, treatment sometimes fails in the primary and/or secondary triplet eradication therapy, including with the use of vonoprazan for hp infection. we experienced three cases of refractory hp ... | 2017 | 28845910 |
| tlr2 arg677trp but not tlr2 -196 to -174 ins/del and arg753gln polymorphism alter the risk of peptic ulcer in north of iran. | most polymorphisms that occur in tlr-2 are associated with gastrointestinal disorders such as peptic ulcer disease (pud). hence, in current study, association between tlr2-196 to -174 ins/del, arg753gln and arg677trp polymorphisms and risk of pud development in north of iran was evaluated. | 2017 | 28844484 |
| helicobacter pylori outer membrane protein q genotypes and their susceptibility to anti-adhesive phytotherapeutic agents. | helicobacter pylori is a gram-negative organism. its outer membrane protein q (hopq) mediates host-pathogen interactions; hopq genotypes 1 and 2 are found associating with gastroduodenal pathologies. the authors measured the anti-adhesion effects of the extracts of abelmoschus esculentus, zingiber officinale, trachyspermum ammi, glycyrrhiza glabra, curcuma longa and capsicum annum against hopq genotypes and h. pylori cytotoxin-associated gene a (caga). | 2017 | 28844217 |
| the arms race between man and mycobacterium tuberculosis: time to regroup. | an arms race is an appropriate metaphor to use for the interaction of man and mycobacterium tuberculosis (m.tb) through the millennia. estimates of the time of infection of modern humans with m.tb often pre-date the out-of-africa migration. humans have adapted to the changing environment during the migration with respect to climate, food sources and encounters with local pathogens. more recently, there has been adaptation to the demographic changes brought about in the majority of the human popu ... | 2017 | 28843547 |
| evaluation and management of gastric epithelial polyps. | gastric polyps include a wide spectrum of lesions with different histology and neoplastic potential. they are found in up to 6% of upper gastrointestinal endoscopy and are usually asymptomatic and incidentally diagnosed, being in the vast majority epithelial gastric polyps. hyperplastic, fundic gland and adenomas are the most common types of gastric polyps and, although each type may have typical endoscopic appearances, they all must be sampled at the initial endoscopy for histological assessmen ... | 2017 | 28842047 |
| specific mutations of penicillin-binding protein 1a in 77 clinically acquired amoxicillin-resistant helicobacter pylori strains in comparison with 77 amoxicillin-susceptible strains. | amoxicillin (amx) is one of the most important antibiotics for eradication of helicobacter pylori (h. pylori). main determinants of genetically stable amx resistance are mutations in the c-terminus of penicillin-binding protein 1a (pbp1a). however, contribution of individual mutation remains unclear. | 2017 | 28840971 |
| pbx1 attributes as a determinant of connexin 32 downregulation in helicobacter pylori-related gastric carcinogenesis. | to clarify the mechanisms of connexin 32 (cx32) downregulation by potential transcriptional factors (tfs) in helicobacter pylori (h. pylori)-associated gastric carcinogenesis. | 2017 | 28839434 |
| "transition state analogue inhibitors of 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase from mycobacterium tuberculosis". | mycobacterium tuberculosis 5'-deoxyadenosine/5'-methylthioadenosine nucleosidase (rv0091) catalyzes the n-riboside hydrolysis of its substrates 5'-methylthioadenosine (mta) and 5-deoxyadenosine (5'-dado). 5'-dado is the preferred substrate, a product of radical sam-dependent enzyme reactions. rv0091 is characterized by a ribocation-like transition state, with low n-ribosidic bond order, an n7 protonated adenine leaving group and an activated but weakly bonded water nucleophile. dadme-immucillin ... | 2017 | 28836767 |
| protective efficacy of a hydroxy fatty acid against gastric helicobacter infections. | we have previously revealed that omega-3 polyunsaturated fatty acids can prevent helicobacter pylori infection by blocking the futalosine pathway, an alternative route for menaquinone (mk) biosynthesis. | 2017 | 28834011 |
| endoscopic characteristics of infection-associated peptic ulcers. | aside from helicobacter pylori, another cause for the development or worsening of gastrointestinal ulcers is scrub typhus, an acute febrile disease caused by orientia tsutsugamushi. we aimed to compare the endoscopic characteristics of peptic ulcers caused by these infectious agents. | 2017 | 28833968 |
| efficacy of three-in-one capsule bismuth quadruple therapy for helicobacter pylori eradication in clinical practice in a multinational patient population. | bismuth quadruple therapy (bqt) has been proven superior to standard triple therapy for helicobacter pylori eradication in randomized clinical trials; however, little is known about the efficacy of bqt in daily routine practice. | 2017 | 28833925 |
| shotgun metagenomic data on the human stool samples to characterize shifts of the gut microbial profile after the helicobacter pylori eradication therapy. | the shotgun sequencing data presented in this report are related to the research article named "gut microbiome shotgun sequencing in assessment of microbial community changes associated with h. pylori eradication therapy" (khusnutdinova et al., 2016) [1]. typically, the h. pylori eradication protocol includes a prolonged two-week use of the broad-spectrum antibiotics. the presented data on the whole-genome sequencing of the total dna from stool samples of patients before the start of the eradica ... | 2017 | 28831408 |
| characteristics and risk factors for sporadic non-ampullary duodenal adenocarcinoma. | despite the gradual increase in the incidence of non-ampullary duodenal adenocarcinoma (nadac), the associated characteristics and risk factors remain poorly understood. the aim of this study was to clarify the clinical characteristics and risk factors of sporadic nadac. | 2017 | 28830268 |
| [the efficacy of moxifloxacin-containing triple therapy after hybrid therapy failure in helicobacter pylori eradication]. | hybrid therapy was successful in eradicating helicobacter pylori (h. pylori) according to previous reports. however, to the best of our knowledge, there have only been a few studies evaluating the optimal choice after hybrid failure. hence, we aimed to evaluate the efficacy of moxifloxacin-containing triple therapy after hybrid therapy failure in h. pylori eradication. | 2017 | 28830132 |
| reduced mir-490-3p expression is associated with poor prognosis of helicobacter pylori induced gastric cancer. | helicobacter pylori (hp) infection has been demonstrated to be a risk factor accounting for the initiation and development of gastric cancer (gc). the aim of the present study was to investigate the clinical significance of mir-490-3p in hp associated gc. | 2017 | 28829504 |
| a comprehensive review on pharmacotherapeutics of three phytochemicals, curcumin, quercetin, and allicin, in the treatment of gastric cancer. | gastric cancer is one of the most common causes of cancer-related death worldwide. medicinal plants are one of the main sources for discovery of new pharmacological agents especially for treatment of cancers. the aim of the present study is to review pharmacotherapeutic aspects of three mostly studied phytochemicals including curcumin, quercetin, and allicin for management of gastric cancer. | 2017 | 28828709 |
| the role of the c-terminal d0 domain of flagellin in activation of toll like receptor 5. | flagellin is a wide-spread bacterial virulence factor sensed by the membrane-bound toll-like receptor 5 (tlr5) and by the intracellular naip5/nlrc4 inflammasome receptor. tlr5 recognizes a conserved region within the d1 domain of flagellin, crucial for the interaction between subunits in the flagellum and for bacterial motility. while it is known that a deletion of the d0 domain of flagellin, which lines the interior of flagella, also completely abrogates activation of tlr5, its functional role ... | 2017 | 28827825 |
| crosstalk between dna damage and inflammation in the multiple steps of carcinogenesis. | inflammation can be induced by chronic infection, inflammatory diseases and physicochemical factors. chronic inflammation is estimated to contribute to approximately 25% of human cancers. under inflammatory conditions, inflammatory and epithelial cells release reactive oxygen (ros) and nitrogen species (rns), which are capable of causing dna damage, including the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-nitroguanine. we reported that 8-nitroguanine was clearly formed at the sites o ... | 2017 | 28825631 |
| oral immunization with a multivalent epitope-based vaccine, based on nap, urease, hsp60, and hpaa, provides therapeutic effect on h. pylori infection in mongolian gerbils. | epitope-based vaccine is a promising strategy for therapeutic vaccination against helicobacter pylori (h. pylori) infection. a multivalent subunit vaccine containing various antigens from h. pylori is superior to a univalent subunit vaccine. however, whether a multivalent epitope-based vaccine is superior to a univalent epitope-based vaccine in therapeutic vaccination against h. pylori, remains unclear. in this study, a multivalent epitope-based vaccine named cwae against h. pylori urease, neutr ... | 2017 | 28824883 |
| advanced non-cardia gastric cancer and helicobacter pylori infection in vietnam. | the incidence of gastric cancer in the northern city, hanoi is higher than in the southern city, ho chi minh, vietnam. we previously reported that helicobacter pylori vaca m1 genotype might be responsible for the difference between the two cities, however, the study only included non-cancer patients. the aim of this study is to investigate the non-cardia gastric cancer characteristics and the role of h. pylori virulence on different non-cardia gastric cancer incidence between two cities in vietn ... | 2017 | 28824711 |
| the exceptional oncogenicity of htlv-1. | human t-cell leukemia virus-1 (htlv-1) is the first pathogenic human retrovirus identified in 1979 by the gallo group. htlv-1 causes fatal t-cell leukemia (adult t cell leukemia) and a progressive myelopahy (htlv-1-associated myelopathy/ tropical spastic paraparesis, ham/tsp) and other disorders. since the discovery of htlv-1, several other microorganisms are demonstrated to cause cancer in humans. in this article, we investigated the oncogenic capacity of htlv-1, in comparison with those of oth ... | 2017 | 28824561 |
| microbes and viruses are bugging the gut in celiac disease. are they friends or foes? | the links between microorganisms/viruses and autoimmunity are complex and multidirectional. a huge number of studies demonstrated the triggering impact of microbes and viruses as the major environmental factors on the autoimmune and inflammatory diseases. however, growing evidences suggest that infectious agents can also play a protective role or even abrogate these processes. this protective crosstalk between microbes/viruses and us might represent a mutual beneficial equilibrium relationship b ... | 2017 | 28824555 |
| identification of distinctive clinical significance in hospitalized patients with endoscopic duodenal mucosal lesions. | duodenitis is not infrequent finding in patient undergoing endoscopy. however, hospitalized patients have a higher incidence of secondary duodenal mucosal lesions that might be related with inflammatory bowel disease (ibd), cytomegalovirus (cmv) infection, tuberculosis, immunologic disorders, or other rare infections. we aimed to identify clinicopathologic features of duodenal mucosal lesions in hospitalized patients. | 2017 | 28823115 |
| [influence of saccharomyces boulardii sachets combined with bismuth quadruple therapy for initial helicobacter pylori eradication]. | objective: to evaluate the efficacy and safety of saccharomyces boulardii sachets combined with bismuth quadruple therapy for initial helicobacter pylori(h.pylori) eradication. methods: from march 2014 to march 2015, 240 participants from the third hospital of hebei medical university with h. pylori infection were recruited and randomized into three groups: quadruple therapy group received bismuth potassium citrate 220 mg bid + rabeprazole 10 mg bid + amoxicillin 1 000 mg bid+ furazolidone 100 m ... | 2017 | 28822453 |
| modifiable factors and esophageal cancer: a systematic review of published meta-analyses. | there are marked differences in the etiology of the major histological types of esophageal cancer (ec)-squamous cell carcinomas (escc) and adenocarcinomas (eac). this study aimed to summarize the current scientific knowledge on modifiable risk factors for ec, by histological type, through a systematic review of meta-analyses referenced in pubmed and isi web of knowledge. we identified 100 meta-analyses on risk factors for escc (n = 54), eac (n = 43), or ec (n = 51). escc risk significantly incre ... | 2017 | 28821981 |
| detection of interactions between proteins by using legendre moments descriptor to extract discriminatory information embedded in pssm. | protein-protein interactions (ppis) play a very large part in most cellular processes. although a great deal of research has been devoted to detecting ppis through high-throughput technologies, these methods are clearly expensive and cumbersome. compared with the traditional experimental methods, computational methods have attracted much attention because of their good performance in detecting ppis. in our work, a novel computational method named as pcvm-lm is proposed which combines the probabi ... | 2017 | 28820478 |
| different look in to the role of flagella in pathogenesis of helicobacter pylori. | 2017 | 28819884 | |
| curcuma wenyujin y. h. chen et c. ling n-butyl alcohol extract inhibits ags cell helicobacter pylori caga+vaca+ promoted invasiveness by down-regulating caudal type homeobox transcription factor and claudin-2 expression. | to investigate the effects and possible mechanisms of action of curcuma wenyujin y. h. chen et c. ling n-butyl alcohol extract (cwnae) on repression of human gastric cancer (gc) ags cell invasion induced by co-culturing with helicobacter pylori (hp). | 2017 | 28819779 |
| effectiveness of helicobacter pylori eradication in the prevention of primary gastric cancer in healthy asymptomatic people: a systematic review and meta-analysis comparing risk ratio with risk difference. | helicobacter pylori infection is strongly associated with gastric cancer occurrence. however, it is unclear whether eradication therapy reduces the risk of gastric cancer occurrence. we evaluated whether h. pylori eradication reduces the risk of primary gastric cancer by using both risk ratio (rr) and risk difference (rd). | 2017 | 28817628 |
| helicobacter pylori infection, atrophic gastritis, and pancreatic cancer risk: a meta-analysis of prospective epidemiologic studies. | to investigate the associations of helicobacter pylori (hp) infection and atrophic gastritis (ag) with pancreatic cancer risk. | 2017 | 28816977 |
| prevalence and characteristics of epstein-barr virus-associated gastric carcinomas in portugal. | gastric cancer (gc) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. epstein-barr virus (ebv) has been associated with approximately 10% of the total cases of gastric carcinomas. no previous study has analyzed the prevalence of ebv infection in gastric cancer of the portuguese population. | 2017 | 28814970 |
| antibiotic susceptibility, heteroresistance, and updated treatment strategies in helicobacter pylori infection. | in this review, we discuss the problem of antibiotic resistance, heteroresistance, the utility of cultures and antibiotic susceptibility tests in helicobacter pylori (hp) eradication, as well as the updated treatment strategies for this infection. the prevalence of antibiotic resistance is increasing all over the world, especially for metronidazole and clarithromycin, because of their heavy use in some geographical areas. heteroresistance (simultaneous presence of both susceptible and resistant ... | 2017 | 28814829 |
| micromotor-enabled active drug delivery for in vivo treatment of stomach infection. | advances in bioinspired design principles and nanomaterials have led to tremendous progress in autonomously moving synthetic nano/micromotors with diverse functionalities in different environments. however, a significant gap remains in moving nano/micromotors from test tubes to living organisms for treating diseases with high efficacy. here we present the first, to our knowledge, in vivo therapeutic micromotors application for active drug delivery to treat gastric bacterial infection in a mouse ... | 2017 | 28814725 |
| may gender or ethnicity affect delta over baseline values obtained by 13-c urea breath test? | 13c-urea breath test (ubt) is a non-invasive test for detecting active h.pylori infection. previous studies showed a correlation of delta over baseline (dob) values with bacterial load, mucosal inflammation and successful eradication. gender has been shown to affect dob in children. aim of our study was to verify whether gender or ethnicity affects dob in adults. | 2017 | 28814259 |
| stromal r-spondin orchestrates gastric epithelial stem cells and gland homeostasis. | the constant regeneration of stomach epithelium is driven by long-lived stem cells, but the mechanism that regulates their turnover is not well understood. we have recently found that the gastric pathogen helicobacter pylori can activate gastric stem cells and increase epithelial turnover, while wnt signalling is known to be important for stem cell identity and epithelial regeneration in several tissues. here we find that antral wnt signalling, marked by the classic wnt target gene axin2, is lim ... | 2017 | 28813421 |
| tifa signaling in gastric epithelial cells initiates the cag type 4 secretion system-dependent innate immune response to helicobacter pylori infection. | helicobacter pylori is a bacterial pathogen that colonizes the human stomach, causing inflammation which, in some cases, leads to gastric ulcers and cancer. the clinical outcome of infection depends on a complex interplay of bacterial, host genetic, and environmental factors. although h. pylori is recognized by both the innate and adaptive immune systems, this rarely results in bacterial clearance. gastric epithelial cells are the first line of defense against h. pylori and alert the immune syst ... | 2017 | 28811347 |
| is there a link between clinical manifestation of gastric anisakiasis and helicobacter pylori infection? | 2017 | 28810728 | |
| evolution of correlation between helicobacter pylori infection and autoimmune liver disease. | the present study was planned to evaluate correlation between helicobacter pylori (hp) infection and autoimmune liver disease (aild). a total of 60 patients diagnosed with aild in affiliated hospital of binzhou medical college were continuously enrolled in the present study. hp infection was detected by 13c-urea breath test. the levels of anti-myeloperoxidase were tested by elisa. the positive rate of anti-nuclear antibody (ana), anti-mitochondrial antibody (ama), anti-smooth muscle antibody (sm ... | 2017 | 28810614 |
| structure-function analyses of metal-binding sites of hypa reveal residues important for hydrogenase maturation in helicobacter pylori. | the nickel-containing enzymes of helicobacter pylori, urease and hydrogenase, are essential for efficient colonization in the human stomach. the insertion of nickel into urease and hydrogenase is mediated by the accessory protein hypa. hypa contains an n-terminal nickel-binding site and a dynamic structural zinc-binding site. the coordination of nickel and zinc within hypa is known to be critical for urease maturation and activity. herein, we test the hydrogenase activity of a panel of h. pylori ... | 2017 | 28809946 |
| isolation of abscisic acid from korean acacia honey with anti-helicobacter pylori activity. | helicobacter pylori (h. pylori) is linked to the development of the majority of peptic ulcers and some types of gastric cancers, and its antibiotic resistance is currently found worldwide. | 2017 | 28808376 |
| binding of the helicobacter pylori oipa causes apoptosis of host cells via modulation of bax/bcl-2 levels. | the h. pylori outer inflammatory protein a (oipa) is an outer membrane protein that contributes to gastric inflammation. oipa is believed to affect intra-cellular signalling and modulate the host signalling pathways. the aim of the current study was to clarify the role of oipa in h. pylori pathogenesis and its effect on host cell signalling pathways. to this end, the oipa gene was isolated and inserted into cloning and expression vectors. the recombinant plasmid was transferred into an expressio ... | 2017 | 28808292 |
| both 14-day hybrid and bismuth quadruple therapies cure most patients with helicobacter pylori infection in populations with moderate antibiotic resistance: a randomized controlled trial. | background & aim: hybrid therapy is a novel two-step treatment achieving a high eradication rate for h. pylori infection. currently, whether this new therapy achieves a higher eradication rate than bismuth quadruple therapy remains an unanswered question. the aim of this prospective, randomized, comparive study was to investigate the efficacies of 14-day hybrid therapy and bismuth quadruple therapy in the treatment of h. pylori infection.methods: from july 2013 to june 2015, eligible h. pylori-i ... | 2017 | 28807915 |
| second-line therapy for helicobacter pylori eradication causing antibiotic-associated hemorrhagic colitis. | helicobacter pylori (h. pylori) eradication rarely develops into antibiotic-associated hemorrhagic colitis (aahc), in which the etiology of colitis remains unclear. we herein report a rare case of aahc caused by second-line therapy for h. pylori eradication. | 2017 | 28806959 |
| new clinical paradigms for treating and preventing antiplatelet gastrointestinal bleeding. | to quantify antiplatelet-related gastrointestinal bleeding (gib), characterize patients at greatest risk and summarize risk-management strategies emphasizing evolving knowledge in acute management of antiplatelet-related bleeding. | 2017 | 28806270 |
| letter: helicobacter pylori in lean and obese patients with non-alcoholic fatty liver disease. | 2017 | 28805327 | |
| nongenetically modified lactococcus lactis-adjuvanted vaccination enhanced innate immunity against helicobacter pylori. | gram-positive enhancer matrix particles (gem) produced by lactococcus lactis can enhance vaccine-induced immune response. however, the mechanism under which this adjuvant mounts the efficacy of orally administered vaccines remains unexplored. | 2017 | 28805287 |
| helicobacter pylori cytotoxin-associated gene a impairs the filtration barrier function of podocytes via p38 mapk signaling pathway. | helicobacter pylori (hp) specific antigens were found deposited in the glomeruli in some kidney diseases. however, the underlying molecular mechanisms remain to be elucidated. the aim of this study was to investigate the effect of cytotoxin associated gene a protein (caga), a key virulence factor of hp, on mouse podocytes. cells were cultured and treated with recombinant caga protein. the expression of the tight junction protein zo-1 and p38 mapk signaling pathway activation were measured with r ... | 2017 | 28803254 |
| helicobacter pylori and its secreted immunomodulator vaca protect against anaphylaxis in experimental models of food allergy. | food allergy is an increasingly common health problem in western populations. epidemiological studies have suggested both positive and negative associations between food allergy and infection with the gastric bacterium helicobacter pylori. | 2017 | 28802077 |
| immune responses against helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis. | to assess whether helicobacter pylori (hp) antibody (ab) reactivity against individual hp antigens is pathogenetically relevant to multiple sclerosis (ms), we systematically investigated prevalence and clinical significance of abs against 14 immunodominant and subdominant hp antigens by elisa and immunoblotting in 139 consecutive ms patients with relapsing-remitting (rrms, n = 102) or secondary progressive (spms, n = 37). sera from 39 patients with parkinson's disease (pd), 21 with alzheimer's d ... | 2017 | 28801580 |
| multicentric randomised study of helicobacter pylori eradication and pepsinogen testing for prevention of gastric cancer mortality: the gistar study. | population-based eradication of helicobacter pylori has been suggested to be cost-effective and is recommended by international guidelines. however, the potential adverse effects of widespread antibiotic use that this would entail have not been sufficiently studied. an alternative way to decrease gastric cancer mortality is by non-invasive search for precancerous lesions, in particular gastric atrophy; pepsinogen tests are the best currently available alternative. the primary objective of gistar ... | 2017 | 28801429 |
| molecular basis for the functions of a bacterial muts2 in dna repair and recombination. | bacterial muts2 proteins, consisting of functional domains for atpase, dna-binding, and nuclease activities, play roles in dna recombination and repair. here we observe a mechanism for generating muts2 expression diversity in the human pathogen helicobacter pylori, and identify a unique muts2 domain responsible for specific dna-binding. h. pylori strains differ in muts2 expression due to variations in the dna upstream sequence containing short sequence repeats. based on western blots, muts2 in s ... | 2017 | 28800560 |
| upfront immunohistochemistry improves specificity of helicobacter pylori diagnosis. a french pathology laboratory point of view. | there is no consensus about the histopathologic methods to detect helicobacter pylori in gastric biopsies to date. we aimed to question about the value of upfront anti-h. pylori immunohistochemistry in this field. | 2017 | 28799687 |
| helicobacter pylori infection and serum level of pepsinogen are associated with the risk of metachronous gastric neoplasm after endoscopic resection. | patients who have undergone endoscopic resection of early gastric cancers (egcs) are at risk for metachronous gastric neoplasm. | 2017 | 28799258 |
| the hypothesis that helicobacter pylori predisposes to alzheimer's disease is biologically plausible. | there is epidemiological evidence that h. pylori might predispose to alzheimer's disease. to understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells mnk-28 with the h. pylori peptide hp(2-20). we then monitored the activated genes by global gene expression. the peptide modulated 77 genes, of which 65 are listed in the alzbase database and include the hallmarks of alzheimer's disease: app, apoe, psen1, and psen2. a large fraction of modula ... | 2017 | 28798312 |
| the characteristics and prognosis of diffuse-type early gastric cancer diagnosed during health check-ups. | because of the poor prognosis of diffuse-type gastric cancer, early detection is important. we investigated the clinical characteristics and prognosis of diffuse-type early gastric cancer (egc) diagnosed in subjects during health check-ups. | 2017 | 28798286 |
| marked improvement in gastric involvement in behçet's disease with adalimumab treatment. | gastric involvement is the least frequent manifestation of behçet's disease, and effective treatment for it unknown. here the case of a patient with gastric involvement in behçet's disease that was markedly improved with adalimumab therapy is presented. a 68-year-old man developed an oral ulcer, erythema, folliculitis, and arthralgia. behçet's disease was suspected; then, prednisolone and colchicine were administered. esophagogastroduodenoscopy showed a punched-out ulcer in the posterior wall of ... | 2017 | 28797990 |
| two populations of less-virulent helicobacter pylori genotypes in bangladesh. | bangladesh has a population with a low gastric cancer risk but high prevalence of helicobacter pylori infection. several studies have examined virulence genes in h. pylori from bangladesh. we analyzed caga and vaca subtypes and their association with severe histology phenotypes, and analyzed population types among bangladeshi strains. we included patients who underwent endoscopy in dhaka. sequences of virulence genes and seven housekeeping genes were obtained by next generation sequencing and co ... | 2017 | 28797101 |
| yes, research matters. | my father was diagnosed with stomach cancer recently. luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. my father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. in his case, the diagnosis started from a suggestion by his doctor to check whether he had a gastric infection with helicobacter pylori, a bacterial species found in the digestive trac ... | 2017 | 28796840 |
| berberine containing quadruple therapy for initial helicobacter pylori eradication: an open-label randomized phase iv trial. | due to increasing antimicrobial resistance, a bismuth-based quadruple regimen has been recommended as an alternative first-line therapy for helicobacter pylori (h pylori) eradication. however, different results are varied greatly and the availability of bismuth was limited in some countries. we assessed the efficacy and safety of 14-day berberine-containing quadruple therapy as an alternative regimen for h pylori eradication. | 2017 | 28796053 |
| helicobacter pylori infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease. | controversy exists concerning the relation between helicobacter pylori (hp) infection and coronary artery disease (cad). we aimed to examine the relationship between hp infection and severity of coronary atherosclerosis in patients with chronic cad. | 2017 | 28794636 |
| the study of memory and executive dysfunction in patients infected with helicobacter pylori. | background infectious agents are considered as potential causes of alzheimer's disease. recently, evidence of a high prevalence of helicobacter pylori (h. pylori) infection in patients with alzheimer's disease has been observed. the aim of this study was to investigate memory and executive function in h. pylori positive persons not suffering from alzheimer's or other marked cognitive disorders. methods this is a cross-sectional study. a total 140 participants were selected using purposive sampli ... | 2017 | 28791919 |
| frequency of infection with helicobacter pylori isolates of different antimicrobial profiles in children and adolescents: a preliminary study. | helicobacter pylori (h. pylori) infection can occur as a mixed infection caused by several strains of h. pylori. | 2017 | 28791844 |
| an evaluation of selected oral health indicators and cariogenic bacteria titer in patients with helicobacter pylori. | studies based on polymerase chain reaction (pcr) techniques indicate that helicobacter pylori can be constantly or temporarily present in the oral cavity in virulent or non-virulent form. streptococcus mutans exerts a strong inhibitory effect on h. pylori. | 2017 | 28791813 |
| reducing the flexibility of type ii dehydroquinase enzyme for inhibition - a fragment-based approach and molecular dynamics simulation study. | a multidisciplinary approach was used to identify and optimize a quinazolinedione-based ligand that would reduce the flexibility of the substrate-covering loop (catalytic loop) of the type ii dehydroquinase from helicobacter pylori. this enzyme, which is essential for the survival of this bacterium, is involved in the biosynthesis of the aromatic amino acids. a computer-aided fragment-based protocol (alta) was first employed to identify the aromatic fragments able to block the interface pocket t ... | 2017 | 28791799 |
| comment on "effects of helicobacter pylori treatment on rosacea: a single-arm clinical trial study". | 2017 | 28791740 |