Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| targeting and retention of hpv16 e7 to the endoplasmic reticulum enhances immune tumour protection. | the endoplasmic reticulum (er) is where the major histocompatibility complex (mhc) class i molecules are loaded with epitopes to cause an immune cellular response. most of the protein antigens are degraded in the cytoplasm to amino acids and few epitopes reach the er. antigen targeting of this organelle by calreticulin (crt) fusion avoids this degradation and enhances the immune response. we constructed a recombinant adenovirus to express the e7 antigen with an er-targeting signal peptide (sp) p ... | 2010 | 19818090 |
| the biological properties of e6 and e7 oncoproteins from human papillomaviruses. | more than 100 different human papillomavirus (hpv) types have been isolated so far, and they can be sub-grouped in cutaneous or mucosal according to their ability to infect the skin or the mucosa of the genital or upper-respiratory tracts. a sub-group of human mucosal hpvs, referred to as high-risk hpv types, is responsible for approximately 5% of all human cancers, which represents one-third of all the tumours induced by viruses. epidemiological and biological studies have shown that hpv16 is t ... | 2010 | 19838783 |
| abrogation of the brd4-positive transcription elongation factor b complex by papillomavirus e2 protein contributes to viral oncogene repression. | the cellular bromodomain protein brd4 is a major interacting partner of the papillomavirus (pv) e2 protein. interaction of e2 with brd4 contributes to viral episome maintenance. the e2-brd4 interaction also plays an important role in repressing viral oncogene expression from the integrated viral genome in human pv (hpv)-positive cancer cells. however, the underlying mechanism is not clearly understood. in host cells, brd4 recruits positive transcription elongation factor b (p-tefb) to stimulate ... | 2010 | 19846528 |
| differential binding patterns to host cells associated with particles of several human alphapapillomavirus types. | the focus of this research was to compare the binding profiles of human papillomavirus (hpv) 11, 16, 18 and 45 virus-like particles (vlps) to hacat cells and to the extracellular matrix (ecm) secreted by these cells. all four hpv types tested bind to a component(s) of the ecm. hpv11 vlp binding is blocked when the ecm is pretreated with an anti-laminin 5 (ln5) polyclonal antibody. a series of treatments utilizing heparins and heparinase revealed that hpv18 vlps are dependent on heparan sulfates ... | 2010 | 19846678 |
| high-risk human papilloma virus infection, tumor pathophenotypes, and brca1/2 and tp53 status in juvenile breast cancer. | juvenile breast cancer is rare and poorly known. we studied a series of five breast cancer patients diagnosed within 25 years of age that included two adolescents, 12- and 15-years-old, and 3 young women, 21-, 21-, and 25-years-old, respectively. all cases were scanned for germline mutations along the entire brca1/2 coding sequences and tp53 exons 4-10, using protein truncation test, denaturing high performance liquid chromatography and direct sequencing. paraffin-embedded primary tumors (availa ... | 2010 | 19851859 |
| signature sequence validation of human papillomavirus type 16 (hpv-16) in clinical specimens. | persistent infection indicated by detection of human papillomavirus 16 (hpv-16) on repeat testing over a period of time poses the greatest cervical cancer risk. however, variants of hpv-16, hpv-31 and hpv-33 may share several short sequence homologies in the hypervariable l1 gene commonly targeted for hpv genotyping. the purpose of this study was to introduce a robust laboratory procedure to validate hpv-16 detected in clinical specimens, using the genbank sequence database as the standard refer ... | 2010 | 19858529 |
| prevalence and type distribution of human papillomavirus infection in women from datong, china. | this survey of 931 cervical specimens in women from datong, china indicates that the overall human papillomavirus (hpv) prevalence was 18.6%, and the most prevalent high-risk hpv types were 16, 58, 18, 52 and 33. this study demonstrates the epidemiology of hpv infection in datong and the potential impact of vaccination in this region. | 2010 | 19883160 |
| all 4 di-leucine motifs in the first hydrophobic domain of the e5 oncoprotein of human papillomavirus type 16 are essential for surface mhc class i downregulation activity and e5 endomembrane localization. | the e5 oncoprotein of human papillomavirus type 16 downregulates surface mhc class i and interacts with the heavy chain of the mhc complex via the first hydrophobic domain, believed to form the first helical transmembrane region (tm1) of e5. tm1 contains 4 equally spaced di-leucine (ll1-ll4) motifs. di-leucine motifs have been implicated in protein-protein interactions and as localization signals. to see if any of the 4 di-leucine motifs of tm1 are involved in mhc downregulation by e5, we mutate ... | 2010 | 19876920 |
| erythema multiforme following vaccination for human papillomavirus. | erythema multiforme (em) is an acute self-limited immune-mediated reaction manifested by target skin lesions with mucous membrane involvement. the most common causes are infections and drugs. vaccinations have been reported as a triggering factor, and they may be a frequent cause of em in childhood. a 19-year-old female developed several target lesions of the hands and feet 10 days after the second dose of human papillomavirus (hpv) vaccine. clinico-histologically, a diagnosis of em minor was ma ... | 2010 | 19887766 |
| human papillomavirus genotypes in invasive cervical cancer in jordan. | 2010 | 19892334 | |
| women >or=30 years of age with low grade squamous intraepithelial lesion (lsil) have low positivity rates when cotested for high-risk human papillomavirus: should we reconsider hpv triage for lsil in older women? | high-risk human papillomavirus (hr-hpv) testing for colposcopy triage of low grade squamous intraepithelial lesion (lsil) is not recommended because of high positive rates in young women. it remains unclear whether hr-hpv testing may be useful for triage of older women. we compiled hr-hpv data for women aged >or=30 years with lsil for the period march 1, 2006 to february 28, 2008. follow-up cervical biopsy information was collected for the period march 1, 2006 to august 15, 2008. we used the hyb ... | 2010 | 19894254 |
| cost-effectiveness analysis of human papillomavirus (hpv) vaccination in the netherlands: recent publication reinforces favorable cost-effectiveness despite misleading conclusion. | 2010 | 19896454 | |
| women with hiv are more commonly infected with non-16 and -18 high-risk hpv types. | to review and summarize evidence from clinical, translational and epidemiologic studies which have examined the clinically relevant aspects of hpv type prevalence and cervical dysplasia in hiv-infected women. | 2010 | 19906410 |
| prevalence of human papillomavirus genotypes, and mucosal iga anti-viral responses in women with cervical ectopy. | data on the prevalence of different human papillomavirus (hpv) genotypes and the associated mucosal immune response in women with cervical ectopy are scarce. | 2010 | 19906557 |
| biomarkers in cervical screening: quantitative reverse transcriptase pcr analysis of p16ink4a expression. | molecular insights into the human papillomavirus (hpv)-induced cervical carcinogenesis led to the discovery of biomarkers for cervical disease. the detection of cellular proteins that are overexpressed by hpv-infected cells, such as tumor suppressor protein p16(ink4a), might play an important role in future cervical cancer screening strategies. p16(ink4a) immunostaining correlates with the severity of cytological and histological abnormalities, but shows some methodological shortcomings such as ... | 2010 | 19910796 |
| substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection. | the identification and optimization of a series of substituted tetrahydro-beta-carbolines with potent activity against human papillomavirus is described. structure-activity studies focused on the substitution pattern and chirality of the beta-carboline ring system are discussed. optimization of these parameters led to compounds with antiviral activities in the low nanomolar range. | 2010 | 19914830 |
| selective targeting of hpv-16 e6/e7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo. | recent studies have shown that oncolytic adenovirus specifically targeted tumor cells while sparing normal cells. here, we report a novel e1a-mutant adenovirus (m6) with antisense hpv16 e6 e7 dna inserted into the deleted 6.7k/gp19k region of e3. the target effects of m6 on hpv16-positive cervical cancer cells were evaluated in vivo and in vitro. by using cytopathic effect (cpe) and viral replication assays, we verified m6 was competent to selectively replicate in cervical cancer cells in vitro. ... | 2010 | 19903581 |
| eligibility and willingness of first-year students entering university to participate in a hpv vaccination catch-up program. | in france, human papillomavirus (hpv) vaccine is routinely recommended for 14-year-old girls; a catch-up vaccination should be offered to girls and women 15-23 years of age before the first time they have sex or within the first year after sexual activity begins. the aim of the present study was to examine the eligibility and willingness of first-year college students of toulouse university (france) to participate in a hpv vaccination catch-up program, and to estimate their knowledge of hpv vacc ... | 2010 | 19926199 |
| high level protein expression in plants through the use of a novel autonomously replicating geminivirus shuttle vector. | we constructed a novel autonomously replicating gene expression shuttle vector, with the aim of developing a system for transiently expressing proteins at levels useful for commercial production of vaccines and other proteins in plants. the vector, pric, is based on the mild strain of the geminivirus bean yellow dwarf virus (beydv-m) and is replicationally released into plant cells from a recombinant agrobacterium tumefaciens ti plasmid. pric differs from most other geminivirus-based vectors in ... | 2010 | 19929900 |
| an analysis on the combination expression of hpv l1 capsid protein and p16ink4a in cervical lesions. | human papillomavirus (hpv) infection in cervix is the most important reason for cervical cancer, but only 2% cervical hpv infection will develop into cervical cancer. so how to identify patients at risk of progressive cervical lesions from those infected with hpv to avoid over treatment is a big issue in clinic. the aims of this study were to detect the expression of hpv l1 capsid protein and p16(ink4a) in cervical lesions and to investigate the combination expression of hpv l1 capsid protein an ... | 2010 | 19941368 |
| anal-rectal cytology: a review. | the incidence of invasive anal squamous cell carcinoma, a human papilloma virus (hpv) related cancer, is on the rise, especially in hiv positive men who have sex with men (msm). like cervical cancer, anal cancer is associated with precursor lesions detectable on exfoliative cytology as squamous intraepithelial lesions and on biopsy as intraepithelial neoplasia. anal-rectal cytology screening programs, similar to cervical cytology screening programs, have been developed in an effort to detect and ... | 2010 | 19941374 |
| immunization for hiv-positive individuals. | this review summarizes recent literature addressing immunization in the setting of hiv infection, with a specific focus on emerging evidence that can guide the care of hiv-positive adults. | 2010 | 19949327 |
| enhancing the scope of conventional cervical cytology for detecting hpv infection. | cervical neoplasia is attributed to a persistent human papilloma virus infection. the pap smear being the mainstay of cervical cancer screening in low-resource settings, we studied the nonclassical features which might indicate hpv infection. these included abortive koilocytes, mild dyskeratosis, parakeratosis, mild nuclear hyperchromasia, bi/multinucleation, measles cells, and keratohyaline-like granules. two hundred and eight women with a satisfactory pap smear and a hybrid capture ii test wer ... | 2010 | 19950400 |
| human papillomavirus prevalence and cytopathology correlation in young ugandan women using a low-cost liquid-based pap preparation. | screening for hpv-driven cervical dysplasia and neoplasia is a significant public health concern in the developing world. the purpose of this study was to use a manual, low-cost liquid-based pap preparation to determine hpv prevalence in hiv-positive and hiv-negative young women in kampala, uganda and to correlate cervical cytopathology with hpv-dna genotype. about 196 post-partum women aged 18-30 years underwent rapid hiv testing and pelvic examination. liquid-based cervical cytology samples we ... | 2010 | 19937939 |
| human papillomavirus knowledge and vaccine acceptability among a national sample of heterosexual men. | if approved for use in young males in the united states, prophylactic human papillomavirus (hpv) vaccine may reduce the incidence of hpv-related disease in vaccinated males and their sexual partners. we aimed to characterise heterosexual men's willingness to get hpv vaccine and identify correlates of vaccine acceptability. | 2010 | 19951936 |
| appendix to: "pcr detection rates of high risk human papillomavirus dna in paired self-collected urine and cervical scrapes after laser co(2) conization for high-grade cervical intraepithelial neoplasia". | 2010 | 19969337 | |
| interaction of immunological genes on chromosome 2q33 and ifng in susceptibility to cervical cancer. | cervical cancer is caused by persistent infection with human papillomavirus and genetic susceptibility factors may augment disease risk. the immune response consists of complex interactions and it was recently proposed that the association of combinations of genotypes at several genes should be examined. in support of this the combination cd28+17(tt)/ifng+874(aa) was shown to increase cervical cancer risk in a brazilian population (vb guzman et al. new approach reveals cd28 and ifng gene interac ... | 2010 | 19959217 |
| type-specific human papillomavirus oncogene messenger rna levels correlate with the severity of cervical neoplasia. | this study aimed to evaluate whether quantitation of high-risk human papillomavirus (hr-hpv) e6 messenger rna (mrna) can be a potential biomarker for detecting the severity of cervical lesions. hpv genotyping was performed using a modified my11/gp6+ pcr for hpv dna amplification, followed by hpv genotype-specific hybridization with on a gene chip. e6 type-specific pcr was used to validate multiple infections. quantitative real-time reverse transcriptase (qrt-pcr) and real-time pcr used to measur ... | 2010 | 19960432 |
| naturally occurring systemic immune responses to hpv antigens do not predict regression of cin2/3. | essentially all squamous cervical cancers and their precursor lesions, high grade cervical intraepithelial neoplasia (cin2/3), are caused by persistent human papillomavirus (hpv) infection. however, not all cin2/3 lesions progress to cancer. in a brief, observational study window monitoring subjects with cin2/3 from protocol entry (biopsy diagnosis) to definitive therapy (cervical conization) at week 15, in a cohort of 50 subjects, we found that 26% of cin2/3 lesions associated with hpv16, the g ... | 2010 | 20012604 |
| the precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer. | although cooking emission from high-temperature frying has been deemed a group 2a carcinogen by the international agency for research on cancer, little is known about its impact on cervical tumorigenesis. to investigate the precancerous consequence of cooking oil fumes on cervical intraepithelial neoplasm (cin), a community-based case-control study, which takes all known risk factors into consideration, was conducted in taiwan. from 2003 to 2008, in a pap smear screening and biopsy examination n ... | 2010 | 20013811 |
| atypical glandular cells (agc): thinprep imaging system (tis), manual screening (ms), and correlation with hybrid capture 2 (hc2) hpv dna testing. | the aim of the study was to determine if the thinprep imaging system (t1s) improves the positive predictive value (ppv) of atypical glandular cell (agc) diagnosis for identifying hpv-related squamous and/or glandular lesions over manual screening (ms), and if human papilloma virus (hpv)-dna testing improves the diagnostic yield. | 2010 | 20014311 |
| malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis. | the objective is to present an uncommon case of squamous cell carcinoma (scc) arising from extensive recurrent respiratory papillomatosis (rrp) involving the upper and lower airway and temporal bone. | 2010 | 20015762 |
| association of polymorphism in fcgr3a gene and progression of low-grade precursor lesions of cervical carcinoma. | polymorphisms in receptors of the constant part of antibodies (fcr) have been associated with susceptibility to disease and viral infections but have not been studied in cervical carcinogenesis. the distribution of the polymorphism v158f (rs396991) in fcgr3a in cervical smears was detected in a group of 84 women with stable or regressed low-grade squamous intraepithelial lesions (group i) and a group of 54 women with high-grade squamous intraepithelial lesions (hsil) (group ii). human papillomav ... | 2010 | 20018222 |
| prophylactic hpv vaccines: the finnish perspective. | finland is a country with a dual role in the human papillomavirus (hpv) field. finnish scientists have pioneered in hpv research and participated in international hpv vaccine trials, but officially finland is reluctant to implement hpv vaccines into its national vaccination program owing to the reasons discussed in this article. in contrast to other european countries, finnish authorities were reluctant to initiate the evaluation process for hpv vaccines after licensure. instead of prompt implem ... | 2010 | 20021305 |
| communication challenges of hpv vaccination. | the uk has introduced a national human papillomavirus (hpv) immunisation programme for girls aged 12-13 from autumn 2008. previous research has explored public understanding of the causes of cervical cancer and found little awareness of the role of hpv. | 2010 | 20022908 |
| the cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. | histone deacetylases (hdacs) are chromatin-modifying enzymes that are involved in the regulation of proliferation, differentiation and development. hdac inhibitors induce cell cycle arrest, differentiation, or apoptosis in tumor cells and are therefore promising antitumor agents. numerous genes were found to be deregulated upon hdac inhibitor treatment; however, the relevant target enzymes are still unidentified. hdac1 is required for mouse development and unrestricted proliferation of embryonic ... | 2010 | 20028735 |
| ccl2 blockade augments cancer immunotherapy. | altering the immunosuppressive microenvironment that exists within a tumor will likely be necessary for cancer vaccines to trigger an effective antitumor response. monocyte chemoattractant proteins (such as ccl2) are produced by many tumors and have both direct and indirect immunoinhibitory effects. we hypothesized that ccl2 blockade would reduce immunosuppression and augment vaccine immunotherapy. anti-murine ccl2/ccl12 monoclonal antibodies were administered in three immunotherapy models: one ... | 2010 | 20028856 |
| recombination of human papillomavirus-16 and host dna in exfoliated cervical cells: a pilot study of l1 gene methylation and chromosomal integration as biomarkers of carcinogenic progression. | human papillomavirus-16 dna replicates in productive infections in circular form, but is found in most carcinomas integrated into the host cell dna. because this transition is essential for carcinogenesis, detailed research is desirable and may help to triage patients with abnormal pap smears. previous studies addressed the chromosomal integration of hpv-16 dna in biopsies of tumors by an indirect biomarker, methylation of the viral l1 gene and by reverse ligation polymerase chain reaction (rlip ... | 2010 | 20029805 |
| the basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from paraguay. | human papillomavirus (hpv) has been reported in 12-82% of penile squamous cell carcinomas (scc). there is an association of the virus with basaloid and warty carcinomas but the reported prevalence is variable. the causes of these variations are not clear. they may be owing to geographic differences, the use of different techniques to detect hpv, the status of the original paraffin blocks, or to variable criteria in tumor classification. the aims of the study were to determine the prevalence of h ... | 2010 | 20035150 |
| [perspective of cervical cancer prevention and control in developing countries and areas]. | cervical cancer ranks the second common cancer in women, affecting women severely in developing countries. it is a critical issue to develop simple, rapid, accurate, safe, acceptable, and inexpensive screening tests which can be used in cervical cancer prevention programs in developing countries. due to the shortage of funding and qualified cytological professionals in most developing countries, who has been actively promoting visual inspection with acetic acid/iodine solution (via/vili) as the ... | 2010 | 20038301 |
| modulation of apoptosis by early human papillomavirus proteins in cervical cancer. | cervical cancer (cc) constitutes a major women health problem. clinical, molecular, and epidemiological investigations have identified persistent infection with high risk human papillomavirus (hr-hpv) as the major cause of cc. hr-hpvs lead to development of cervical carcinoma, predominantly through the action of e5, e6 and e7 viral oncoproteins. after hr-hpv infection, viral proteins employ strategies to modulate apoptosis. the e2 viral protein induces apoptosis in both normal and hpv-transforme ... | 2010 | 19374936 |
| [withdrawal of an advertising campaign to promote the quadrivalent human papilloma virus vaccine in spain]. | the inclusion of the quadrivalent human papilloma virus (hpv) vaccine in the schedule of the spanish national health system sparked the debate over gardasil, which was presented to the public as a "vaccine against cervical cancer". in this context, sanofi pasteur msd was sued for misleading advertising in the campaign "cuentaselo.org". although the complaint was not admitted, the lawsuit triggered five changes in the ownership of the web domain which, although backed by scientific societies, was ... | 2010 | 19523720 |
| proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, tert, or by activation of endogenous telomerase through expression of papillomavirus e6/e7 or the telomerase rna component, terc. | dyskeratosis congenita (dc) is characterized by the triad of reticulate skin pigmentation, nail dystrophy and leukoplakia. epidermal atrophy, hair growth defects, bone marrow failure and increased risk of cancer are also common in dc patients. dc is caused by mutations in genes encoding for telomerase complex factors. although there is an association of epidermal abnormalities with dc, epidermal cells from dc donors have not been previously characterized. we have isolated skin keratinocytes from ... | 2010 | 19558498 |
| age distribution of human papillomavirus infection and cervical neoplasia reflects caveats of cervical screening policies. | although a second age-related peak of human papillomavirus (hpv) infection is observed in many populations, it does not seem to have any impact on cervical screening policies. we examined the age-specific prevalence of hpv infection among 2,604 women enrolled for cervical screening and correlated the age at diagnosis of 2,491 cervical intraepithelial neoplasia grade 2/3 (cin2/3) lesions and 801 invasive cervical cancers (icc). two peaks of hpv infection were detected at 26-30 and 46-50 years, re ... | 2010 | 19588497 |
| serological response to an hpv16 e7 based therapeutic vaccine in women with high-grade cervical dysplasia. | infection with oncogenic human papillomaviruses has been linked to the development of cervical neoplasia and cancer. the exclusive expression of e7, a viral oncogene, in infected cells makes this protein an ideal target for immunotherapy. we recently reported on the results of a trial in women with cervical carcinoma-in-situ using hspe7, a protein vaccine consisting of full length hpv16 e7 linked to a heat shock protein from m. bovis. the stimulating effects of hspe7 on specific cytotoxic t lymp ... | 2010 | 19555999 |
| predictors of human papillomavirus persistence among women with equivocal or mildly abnormal cytology. | we investigated short-term persistence of human papillomavirus (hpv) infection among 2,408 women with low-grade or equivocal cytological abnormalities followed for 24 months. odds ratios (ors) for persistence to the next 6-month visit were estimated by a discrete time survival model. prevalent hpv infections persisted longer in older women, but no association with age was found for incident hpv infections. increased likelihood of persistence was found among current smokers of >20 cigarettes per ... | 2010 | 19609952 |
| transitional cell neoplasm of the nasolacrimal duct associated with human papillomavirus type 11. | tumors of the lacrimal sac are rare but noteworthy because of their significant potential to become malignant or life-threatening if treatment is delayed. dermatologists may be the first to encounter such neoplasms. | 2010 | 19615034 |
| human papilloma virus screening by hybrid capture ii in chinese women of jiangsu province. | to survey human papilloma virus (hpv) infection in chinese women of jiangsu province and discuss the relationship between hpv and the biology of cervical cancer. | 2010 | 21473391 |
| [morphological and immunohistochemical studies of palatine tonsillar hypertrophy in children]. | the paper presents the results of immunohistochemical and morphometric studies conducted to examine an association of the site, the expression of virus antigens, and the nature of morphological changes in the hypertrophic palatine tonsils in children. the distribution of cd3+ and cd20+ cells was explored in tonsillar tissue. the greatest changes were shown in the epithelium, the antigens of herpex simplex virus being more frequently detected than those of human papillomavirus. the presented data ... | 2010 | 21400774 |
| disconnects between news framing and parental discourse concerning the state-mandated hpv vaccine: implications for dialogic health communication and health literacy. | in 2007, virginia became the first state in the us to mandate the human papillomavirus (hpv) vaccine. in 2009, the mandate required that parents of girls entering sixth grade (ages 11-12) vaccinate their daughters or sign the 'opt-out' waiver. this investigation is the first to explore how both the news media and parents framed and responded to the newly-mandated hpv vaccine. this research reveals disjoints between news media framing and parental framing. implications of these gaps for parental ... | 2010 | 21462859 |
| human papillomavirus and cervical neoplasia among female sex workers in madagascar. | human papillomavirus (hpv) prevalence and type distribution were estimated among 90 female sex workers (fsws) aged 18 to 58 years in antananarivo, madagascar. | 2010 | 21370602 |
| oral zinc sulfate treatment for viral warts: an open-label study. | viral warts, which are caused by the human papilloma virus, are a common problem in dermatology. various modalities have been used to treat warts, but none are uniformly effective or directly antiviral. recent studies show that oral zinc sulfate could be effective in the treatment of viral warts. thirty-one patients with multiple, non-genital viral warts were recruited in this open-label clinical study. the patients were treated with oral zinc sulfate (10 mg/kg to a maximum dose of 600 mg/day) f ... | 2010 | 21352302 |
| molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in turkish pregnants. | human cytomegalovirus (cmv) is the most common cause of viral intrauterine infections in the world. herpes simplex virus type 2 (hsv-2) and human papillomavirus (hpv) are the main agents of viral sexually transmitted diseases, which cause genital ulcers and genital warts, respectively. hpv infection has been linked to the majority of the anogenital malignancies. the aim of this study was to detect the existence of cmv, hsv-2 and hpv type 16-18 in turkish pregnants by using sensitive molecular as ... | 2010 | 21340297 |
| human papillomaviruses prevalence and genital co-infections in hiv-seropositive women in ouagadougou (burkina faso). | the vaginal swabs among hiv-positive women in africa often revealed opportunistic infections such as human papillomavirus (hpv) and mycoplasma that induce respectively cervix cancer and diseases such as vaginosis, abortions, infertility in through salpingitis. the purposes of this study were to: (1) seek for, the prevalence of pathogens such as hpv and mycoplasma; (2) characterize the strains of hpv and estimate their prevalence; (3) identify among these women, those who were co-infected by thes ... | 2010 | 21313918 |
| koilocytes are enriched for alkaline-labile sites. | this study investigated possible variations in the chromatin structure of koilocytes resulting from human papillomavirus (hpv) infection. alkaline-labile sites (als) were detected with the dna breakage detection–fluorescence in situ hybridization (dbd-fish) technique using a whole human genome dna probe obtained from individuals without koilocytosis. the variable levels of als present were measured quantitatively using image analysis after whole-genome dna hybridization. a significant increase i ... | 2010 | 21337807 |
| prevalence of high-risk human papillomavirus infection and cytologic results in thailand. | cervical cancer is the second most common female cancer with a high mortality rate. the established cause is high-risk types of human papillomavirus (hpv) and a new modality for cervical cancer screening is the combination of cervical cytology with hpv testing. the aim of present study was to identify the prevalence of high-risk hpv infection, and cervical cytological profiles of healthy thai women. this largest cross-sectional investigation of hpv testing so far with cytology screening in thail ... | 2010 | 21338181 |
| perceptions and opinions regarding human papilloma virus vaccination among young women in malaysia. | the objective of this study is to explore the perceptions and opinions of young women about human papilloma virus (hpv) vaccination and associated barriers. | 2010 | 21338190 |
| assessing the role of education on turkish university students' knowledge about hpv and related diseases. | human papillomavirus (hpv) is one of the most common sexually transmitted causes of infections and adolescents are at high risk. the aim of the study was to evaluate university students' hpv knowledge before and after educational intervention on hpv. | 2010 | 21338219 |
| awareness and knowledge about human papillomavirus among latina immigrants. | few studies have examined associations with the public's awareness and knowledge of the human papillomavirus (hpv) among latina immigrants. the primary purpose of this study was to assess hpv awareness and knowledge, while examining demographic and healthcare utilization associations. | 2010 | 21305817 |
| [prevalence and determinants of lower reproductive tract infections among women aged 25 - 54 years in beijing.] | objective: to determine the prevalence and determinants of the most commonly seen lower reproductive tract infections among women aged 25 - 54 years in beijing. methods: the study population consisted of 6339 women aged 25 - 54 years in 137 communities of beijing. focus of this study was to understand the prevalence of the following diseases as:bacterial vaginosis, trichomoniasis and vulvovaginal candidiasis. in addition to their prevalence rates, a generalized equation for estimation was used t ... | 2010 | 21215070 |
| distribution of hpv genotypes in women with cervical cancer in auckland, new zealand; a review of 50 specimens between 2000-2006. | in new zealand, around two hundred women are diagnosed with cervical cancer annually, with approximately seventy deaths from cervical cancer per year. | 2010 | 21299512 |
| decision-analytic modeling to evaluate the long-term effectiveness and cost-effectiveness of hpv-dna testing in primary cervical cancer screening in germany. | persistent infections with high-risk types of human papillomavirus (hpv) are associated with the development of cervical neoplasia. compared to cytology hpv testing is more sensitive in detecting high-grade cervical cancer precursors, but with lower specificity. hpv based primary screening for cervical cancer is currently discussed in germany. decisions should be based on a systematic evaluation of the long-term effectiveness and cost-effectiveness of hpv based primary screening. | 2010 | 21289878 |
| what is your diagnosis? bowenoid papulosis. | 2010 | 21284277 | |
| comparison of the diagcor genoflow human papillomavirus array test and roche linear array hpv genotyping test. | persistent infection of high-risk (hr) human papillomavirus (hpv) infection has been widely associated with cervical cancer. monitoring hpv infection is therefore an important step against cervical cancer development. the diagcor genoflow human papillomavirus array test (genoflow) is a novel hpv test based on pcr and "flow-through" hybridization that can identify 33 hpv subtypes in 3 hours. in the present study, the genoflow test was evaluated by comparing the genotyping results of 100 samples w ... | 2010 | 21270940 |
| is human papillomavirus screening preferable to current policies in vaccinated and unvaccinated women? a cost-effectiveness analysis. | italy was the first european nation to offer free vaccination against human papillomavirus (hpv) types 16 and 18. the vaccination is actively encouraged and is available free of charge to 11-year-old girls. the introduction of new technologies such as hpv dna testing and hpv vaccination requires cost-effectiveness analysis of cervical cancer strategies in italy for both vaccinated and unvaccinated women. | 2010 | 21258128 |
| stepwise algorithm combining hpv high-risk dna-based assays and rna-based assay for high grade cin in women with abnormal smears referred to colposcopy. | the detection of high-risk human papillomavirus (hpv) dna provides higher sensitivity but lower specificity than cytology for the identification of high-grade cervical intraepithelial neoplasia (cin). | 2010 | 21263189 |
| human papillomavirus and predictors of cervical intraepithelial neoplasia among young mothers in a prospective follow-up study. | to study the incidence times and rates for cervical intraepithelial neoplasia (cin) and its predictors. | 2010 | 21241262 |
| high-risk hpv dna status and p16 (ink4a) expression as prognostic markers in patients with squamous cell cancer of oral cavity and oropharynx. | to determine and compare the influence of the hpv dna status and p16(ink4a) expression on the outcome of postoperative radiotherapy for squamous cell cancer of the oral cavity or oropharynx. | 2010 | 21225495 |
| can self vaginal douching for high risk hpv screening replace or assist efficacy of cervical cancer screening? | to study the accuracy of self vaginal douching and collection for hpv types 16, 18, 31 and 33 in women visiting thammasat hospital for the explicit purpose of cervical screening. | 2010 | 21198300 |
| comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study. | human papillomavirus (hpv) infection is a major risk factor for the development of nearly all cases of cervical cancer worldwide. the presence of hpv dna in cases of esophageal squamous-cell carcinoma (escc) has been reported repeatedly from shantou, china, and other regions with a high incidence of esophageal carcinoma (ec). however, unlike in cervical squamous-cell carcinoma (cscc), in escc, the characteristics of hpv are unclear. thus, the role of high-risk hpv types in the carcinogenesis of ... | 2010 | 21108842 |
| human papillomavirus vaccine coverage in the united states, national health and nutrition examination survey, 2007-2008. | this study aims to estimate human papillomavirus (hpv) vaccine coverage by demographic and sexual behavior characteristics 1-2 years after vaccine licensure in a nationally representative sample of females aged 9-59 years in the united states. | 2010 | 21108962 |
| the influence of multiple human papillomavirus types on the risk of genotype-concordant incident infections of the anus and cervix: the hawaii hpv cohort study. | the influence of multiple human papillomavirus (hpv) types on detection of concordant incident hpv infections of the cervix or anus following infection at the other anatomic site was examined in a cohort of 897 women. multiple hpv infections at the anus were not significantly associated with subsequent acquisition of a concordant cervical infection, whereas prior coinfections in the cervix increased risk of a new cervical hpv infection. incident anal hpv infections following concordant cervical ... | 2010 | 21208924 |
| evidence of human papillomavirus in the placenta. | human papillomavirus (hpv) is an epitheliotropic virus typically infecting keratinocytes but also possibly epithelial trophoblastic placental cells. in the present study, we set out to investigate whether hpv can be recovered from transabdominally obtained placental cells to avoid any confounding contamination by hpv-infected cervical cells. thirty-five placental samples from women undergoing transabdominal chorionic villous sampling were analyzed, and we detected hpv-16 and hpv-62 in 2 placenta ... | 2010 | 21208925 |
| [the treatment research of people with different types of hpv infection in sterile patients]. | explore the optimal treatment of infertility patients infected with different types of human papillomavirus (hpv). | 2010 | 21186535 |
| two distinct pathways to development of squamous cell carcinoma of the vulva. | squamous cell carcinoma (scc) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. the future numbers of patients with vulvar scc is expected to rise, mainly because of the proportional increase in the average age of the general population. two different pathways for vulvar scc have been put forth. the first pathway is triggered by infection with a high-risk-type human papillomavirus (hpv). integration of the hpv dna into the host geno ... | 2010 | 21188235 |
| long-term persistence of systemic and mucosal immune response to hpv-16/18 as04-adjuvanted vaccine in preteen/adolescent girls and young women. | vaccination against oncogenic human papillomavirus (hpv) types is one key intervention for cervical cancer prevention. this follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the hpv-16/18 as04-adjuvanted vaccine administered to young women aged 10-25 years. serum and cervicovaginal secretion (cvs) samples were collected at pre-specified time-points during the 48-month follow-up period. anti-hpv-16/18 antibody levels in serum ... | 2010 | 21190190 |
| hpv prophylactic vaccination: the first years and what to expect from now. | new prophylactic hpv vaccines have the power to prevent many hpv infections, thus reducing the burden of hpv-associated diseases. two vaccines composed of hpv l1 proteins self assembled into virus-like particles (vlps) have been developed: one containing vlps of hpv types 6, 11, 16 and 18, while the other vaccine is composed of hpv 16 and 18 vlps. large phase ii and iii clinical trials to assess prophylactic efficacy have been conducted in which both hpv infection endpoints and disease endpoints ... | 2010 | 21190794 |
| performance of the aptima high-risk human papillomavirus mrna assay in a referral population in comparison with hybrid capture 2 and cytology. | this study compared the aptima human papillomavirus (hpv) (ahpv; gen-probe incorporated) assay, which detects e6/e7 mrna from 14 high-risk types, the hybrid capture 2 hpv dna (hc2; qiagen incorporated) test, and repeat cytology for their ability to detect high-grade cervical lesions (cervical intraepithelial neoplasia grade 2+ [cin2+]) in women referred to colposcopy due to an abnormal papanicolaou (pap) smear. a total of 424 clinical specimens, stored in liquid-based cytology (lbc) vials at roo ... | 2010 | 21191046 |
| the molecular biology of head and neck cancer. | head and neck squamous cell carcinomas (hnsccs) are caused by tobacco and alcohol consumption and by infection with high-risk types of human papillomavirus (hpv). tumours often develop within preneoplastic fields of genetically altered cells. the persistence of these fields after treatment presents a major challenge, because it might lead to local recurrences and second primary tumours that are responsible for a large proportion of deaths. aberrant signalling pathways have been identified in hns ... | 2010 | 21160525 |
| increased plasma levels of adipokines and inflammatory markers in older women with persistent hpv infection. | we observed diminished lymphoproliferation to multiple stimuli in older women with persistent cervical human papillomavirus (hpv) infection. adipokines are a class of inflammatory cytokines that are altered in some persistent infections. the objective was to compare the level of adipokines and inflammatory cytokines in heparinized plasma from women with persistent hpv cervical infection (cases, n=50, oversampled for their weak lymphoproliferation responses) with women with no evidence of persist ... | 2010 | 21167737 |
| vaccine generated immunity targets an hpv16 e7 hla-a2.1-restricted cd8(+) t cell epitope relocated to an early gene or a late gene of the cottontail rabbit papillomavirus (crpv) genome in hla-a2.1 transgenic rabbits. | the newly established hla-a2.1 transgenic rabbit model has proven useful for testing the immunogenicity of well known and computer-predicted a2-restricted epitopes. in the current study we compared the protective immunity induced to a preferred hpv16 e7 a2-restricted epitope that has been relocated to positions within the crpv e7 gene and the crpv l2 gene. epitope expression from both the e7 protein and the l2 protein resulted in increased protection against viral dna challenge of the hla-a2.1 t ... | 2010 | 21167863 |
| human papillomavirus is detectable in barrett's esophagus and esophageal carcinoma but is unlikely to be of any etiologic significance. | barrett's esophagus (be), a known precursor of esophageal adenocarcinoma has recently been associated with human papillomavirus (hpv). p16(ink4a) expression is a recognized surrogate marker of hpv infection in the cervix. | 2010 | 21169053 |
| [prevalence of human papillomavirus in the pubic hair follicles of healthy men and male patients with genital warts]. | human papillomavirus (hpv) commonly exists in healthy individuals, but its prevalence in the pubic hair follicles is not yet clear, nor is the relationship between hpv infection in the pubic hair follicles and the recurrence of genital warts in men. this study aimed to investigate hpv infection in the pubic hair follicles of healthy men and patients with genital warts, and to look into the correlation of hpv infection with recurrent genital warts. | 2010 | 21171259 |
| correlation of cellular immunity with human papillomavirus 16 status and outcome in patients with advanced oropharyngeal cancer. | to determine whether the favorable outcome associated with human papillomavirus (hpv) 16-positive oropharyngeal cancer is related to a patient's adaptive immunity. | 2010 | 21173378 |
| maldi imaging as a specific diagnostic tool for routine cervical cytology specimens. | cervical squamous cell carcinoma (scc) is among the most common malignancies in women worldwide. in developed countries routine cytology screening has dramatically reduced scc mortality within the last three decades. high risk (hr) human papilloma virus (hpv) infection is the main causal factor in nearly 100% of invasive sccs, in most cases of low grade squamous intraepithelial lesion (lsil) and in nearly all cases of high grade squamous intraepithelial lesion (hsil). detection of hr-hpv dna has ... | 2010 | 21174066 |
| variation of human papillomavirus 16 in cervical and lung cancers in sichuan, china. | although the crucial role of human papillomaviruses (hpvs), especially hpv-16 in various cancers has been confirmed, the variation of hpv-16 among different cancers have not been investigated in a specific geographic location. in order to elucidate whether similar hpv-16 variants are involved in different kinds of cancers in the same geographic location, the analysis of sequence variants of e6 and e7 oncogenes and l1 gene of hpv-16 in cervical and lung cancers in sichuan, china, was carried out. ... | 2010 | 21175246 |
| awareness and knowledge of hpv, cervical cancer, and vaccines in young women after first delivery in são paulo, brazil--a cross-sectional study. | the success of hpv vaccination programs will require awareness regarding hpv associated diseases and the benefits of hpv vaccination for the general population. the aim of this study was to assess the level of awareness and knowledge of human papillomavirus (hpv) infection, cervical cancer prevention, vaccines, and factors associated with hpv awareness among young women after birth of the first child. | 2010 | 21176230 |
| [analysis of high risk factors associated with cervical intraepithelial neoplasia in married women aged 25 - 54 years in beijing between 2007 - 2008]. | to investigate high risk factors associated with cervical intraepithelial neoplasia (cin) in married women aged 25 to 54 years in beijing. | 2010 | 21176557 |
| a generally applicable cost-effectiveness model for the evaluation of vaccines against cervical cancer. | this study aimed at evaluating the cost-effectiveness of human papillomavirus virus (hpv) vaccination in france, using a generally applicable succinct cohort model. | 2010 | 21110060 |
| [ttv and hpv co-infection in cervical smears of patients with cervical lesions in littoral of zhejiang province]. | to investigate the prevalence of transfusion-transmitted virus (ttv) and human papillomavirus (hpv) co-infection in cervical smears of patients with cervical lesions in littoral of zhejiang province and analysis of transmitted route. | 2010 | 21110428 |
| evaluation of two commercialised in situ hybridisation assays for detecting hpv-dna in formalin-fixed, paraffin-embedded tissue. | introduction: the role of human papilloma virus (hpv) in the pathogenesis of anogenital dysplasia is now conclusive. however, hpv detection in formalin-fixed and paraffin-embedded tissues remains controversial. therefore, the aim of this study was to evaluate morphological changes directly in tissue specimens using a hpv-dna detection system involving hpv in situ hybridisation. materials and methods: samples from patients with cervical carcinoma were analysed using the genpoint hpv dna probe coc ... | 2010 | 21113720 |
| optimising human papillomavirus self-testing for high risk women. | human papillomavirus self-tests that can be used at home and returned by mail may increase cervical cancer screening rates. growing evidence suggests that self-test methods could increase screening for high-risk and hard-to-reach populations. the purpose of this study was to identify which self-test device women prefer and why. | 2010 | 21115503 |
| re: longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection. | 2010 | 21115883 | |
| [genotyping of oncogenic human papilloma viruses in women with hg sil diagnosis]. | development of primary prevention of cervical cancer in other words a vaccination against selected, oncogenic hpv types, entails an increasing importance of epidemiological studies and prevalence of various types of human papilloma virus. the incidence of hpv varies depending on the geographic location of the population. the effectiveness of primary prevention against hpv 16, 18, in the context of reducing the incidence of cervical cancer will depend, among others, on the prevalence of these typ ... | 2010 | 21117301 |
| immunisation of adolescents in the uk. | the recent introduction of routine immunisation against human papillomavirus (hpv) in adolescent girls in the uk has focused attention on the potential for immunisation in this age group. in this review the authors suggest that this is an opportunity that is not being fully utilised. in particular, there are arguments for adolescent vaccines to boost immunity against bordetella pertussis and neisseria meningitidis infections, and the successful implementation of the hpv vaccine could be taken as ... | 2010 | 21119024 |
| small lymphocytic lymphoma obscuring microscopic tonsillar squamous cell carcinoma: an unknown occurrence with a known primary. | head and neck squamous cell carcinoma (hnscc) often presents with cervical lymph node metastases and at times the primary tumor cannot be identified despite extensive workup. lymphoma is the second most common neoplasm in the head and neck region but is seldom synchronous with hnscc and rarely involves regional mucosal sites. we report herein a rare occurrence of tonsillar involvement by small lymphocytic lymphoma (sll) incidentally detected during the workup for a cervical lymph node scc metast ... | 2010 | 21120710 |
| role of human papillomavirus vaccine in prevention of cervical cancer. | 2010 | 21121382 | |
| human papillomavirus: clinical manifestations and prevention. | human papillomaviruses cause the most common sexually transmitted infection in the world and are responsible for nearly all cases of cervical cancer. genital human papillomavirus infection can be divided into low-risk infections (causing genital warts) and high-risk infections (causing cervical intraepithelial neoplasia, and cervical and other cancers). exposure to human papilloma- virus typically produces a sexually transmitted infection that may progress to a clinically apparent process, such ... | 2010 | 21121531 |
| up-regulation of p18ink4c expression by oncogenic hpv e6 via p53-mir-34a pathway. | binding of p53 to mir-34a promoter activates the expression of tumor suppressive mir-34a. oncogenic hpv infection downregulates mir-34a expression through viral e6 degradation of p53. in this report, we found that mir-34a specifically targets p18ink4c, a cdk4 and cdk6 inhibitor induced by e2f transactivation. hpv18(+) hela cells with ectopic mir-34a expression or by e6 sirna knockdown-induced expression of endogenous mir-34a exhibited a substantial reduction of p18ink4c in a dose-dependent manne ... | 2010 | 21128241 |
| protein flexibility directs dna recognition by the papillomavirus e2 proteins. | although dna flexibility is known to play an important role in dna-protein interactions, the importance of protein flexibility is less well understood. here, we show that protein dynamics are important in dna recognition using the well-characterized human papillomavirus (hpv) type 6 e2 protein as a model system. we have compared the dna binding properties of the hpv 6 e2 dna binding domain (dbd) and a mutant lacking two c-terminal leucine residues that form part of the hydrophobic core of the pr ... | 2010 | 21131281 |