Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| kaposi's sarcoma-associated herpesvirus dna sequences in prostate tissue and human semen. | sequences of novel herpesvirus, kaposi's sarcoma-associated herpesvirus (kshv), have been indentified in kaposi's sarcoma tissue, but it is not known whether the virus is transmitted by sexual contact. | 1996 | 8602183 |
| detection of kaposi's sarcoma-associated herpesvirus-like dna sequence in vascular lesions. a reliable diagnostic marker for kaposi's sarcoma. | a new herpesvirus-like dna sequence (kshv) has been recently identified in kaposi's sarcoma (ks) from patients with aids and non-aids patients. to verify the specificity of the association of this new viral dna with ks, a total of 155 cases of benign and malignant vascular neoplasms sharing similar histogenesis of endothelial derivation were analyzed for the presence of this kshv sequence using the published 330-233 primers by polymerase chain reaction (pcr). the results revealed that all 17 cas ... | 1996 | 8602618 |
| intralesional vinblastine for treating aids-associated kaposi's sarcoma of the oropharynx and larynx. | kaposi's sarcoma (ks), the most frequent malignant neoplasm associated with acquired immunodeficiency syndrome, often involves the oropharynx and larynx. this study evaluated the efficacy of intralesional vinblastine sulfate injection in oropharyngeal and laryngeal ks. twenty-four human immunodeficiency virus-positive patients with a total of 26 ks lesions were treated with injections of 0.1- or 0.2-mg/ml vinblastine sulfate solution. subsequent injections were administered at 4- to 5-week inter ... | 1996 | 8604887 |
| acute inhalation exposure to isobutyl nitrite causes nonspecific blood cell destruction. | abuse of nitrite inhalants is widespread among male homosexuals and has been epidemiologically correlated with seropositivity to human immunodeficiency virus (hiv) and to kaposi's sarcoma. these drugs may act as cofactors in aids if they compromise the ability to resist infection or tumor growth. we have previously reported that 14 daily 45-minute exposure to 900 ppm isobutyl nitrite in an inhalation chamber did compromise the immunocompetence of mice. we now report that a single 45-minute expos ... | 1996 | 8605963 |
| primary body cavity-based aids-related lymphomas. | five patients with advanced aids developed a unique type of high grade primary body cavity-based non-hodgkin's lymphoma (nhl). the lymphomas were exclusively in serous effusions with no detectable mass disease in the body cavities and no lymphadenopathy or organomegaly. all of the lymphomas exhibited virtually identical morphology, which could not be precisely classified, but appeared to bridge features of large cell immunoblastic and anaplastic large cell lymphomas. immunophenotypically the lym ... | 1996 | 8607449 |
| long-term follow-up of non-hiv kaposi's sarcoma treated with low-dose recombinant interferon alfa-2b. | we reviewed the follow-up of 16 patients with kaposi's sarcoma not related to human immunodeficiency virus (13 with classic kaposi's sarcoma and three with endemic kaposi's sarcoma; median age, 58 years) treated by low-dose recombinant interferon alfa-2b (5 million u three times weekly for at least 6 months). | 1996 | 8607632 |
| treatment of kaposi's sarcoma. | the classic form of kaposi's sarcoma (ks) is a rare multifocal neoplasm, as described by kaposi in 1872. one hundred nine years after kaposi's first description of the disease, the interest in all aspects of this disease escalated because of the emergence of human immunodeficiency virus (hiv), which is frequently accompanied by ks. this prompted zealous research, as reflected by numerous reports. despite recent important discoveries, we are still far from understanding the pathogenesis of the di ... | 1996 | 8607639 |
| transgenic models of human immunodeficiency virus type-1. | transgenic models have provided significant insights into hiv-1 pathogenesis, particularly with regards to kaposi's sarcoma. hiv-associated nephropathy, the tissue-restricted expression of cns strains of hiv-1, and the function of nef in vivo. both multigenic and single gene constructs have contributed to our understanding of hiv-1-induced diseases. while failing to provide models suitable for vaccine development, these transgenic models have provided great insight into hiv pathogenesis and may ... | 1996 | 8608718 |
| absence of kaposi's-sarcoma-associated herpesvirus-like dna sequences (kshv) in angiosarcomas developing in body-cavity and other sites. | 1996 | 8608959 | |
| antibodies to butyrate-inducible antigens of kaposi's sarcoma-associated herpesvirus in patients with hiv-1 infection. | the recent identification in patients with kaposi's sarcoma of dna sequences with homology to gammaherpesviruses has led to the hypothesis that a newly identified virus, kaposi's sarcoma-associated herpeslike virus (kshv), has a role in the pathogenesis of kaposi's sarcoma. we developed serologic markers for kshv infection. | 1996 | 8609946 |
| aids and cerebrovascular disease. | although neurological complications of human immunodeficiency virus (hiv) infection are common, the presence of cerebrovascular disease (cvd) has been seldom reported. the purpose of this report is to review available data on the association between stroke and acquired immunodeficiency syndrome (aids). | 1996 | 8610326 |
| human herpesvirus-8 dna sequences in human immunodeficiency virus-negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy with giant germinal center hyperplasia and increased vascularity. | human herpesvirus-8 (hhv-8) dna sequences have been reported to be strictly associated not only with various forms of kaposi's sarcoma but also with an unusual subgroup of acquired immunodeficiency syndrome (aids)-related b-cell lymphomas. a possible relation of this putative virus also with multicentric castleman's disease (mcd) has been recently suggested. we used polymerase chain reaction to look for the presence of hhv-8 sequences in a well characterized series of benign, atypical, and malig ... | 1996 | 8611719 |
| human herpesvirus 8 in lymphoma and kaposi's sarcoma: now the virus can be propagated. | 1996 | 8612221 | |
| lytic growth of kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. | kaposi's sarcoma (ks) is the leading neoplasm of aids patients, and hiv infection is known to be a major risk factor for its development. however, ks can occur in the absence of hiv infection and the risk of ks development varies widely even among hiv-infected patients, with homosexual men with aids being 20 times more likely to develop ks than aids-afflicted children or hemophiliacs. these and other data strongly suggest that a sexually transmitted agent or co-factor may be involved in ks patho ... | 1996 | 8612236 |
| presentation of aids-related pulmonary kaposi's sarcoma diagnosed by bronchoscopy. | kaposi's sarcoma (ks) is the most common neoplasm in persons infected with the human immunodeficiency virus (hiv). however, information about the presenting features of pulmonary ks is limited. to describe the clinical, laboratory, and radiographic features of pulmonary ks, medical records and chest radiographs of 168 patients with pulmonary ks diagnosed by bronchoscopy during a 7-yr period were reviewed. all of the patients were hiv-seropositive males, of whom 95% identified homosexual or bisex ... | 1996 | 8616570 |
| cutaneous cryptococcus infection and aids. report of 12 cases and review of the literature. | cryptococcal infections occur in 6% to 13% of patients with acquired immunodeficiency syndrome (aids), most commonly infecting the central nervous system. cutaneous lesions have been described morphologically as umbilicated papules, nodules, and violaceous plaques and can mimic molluscum contagiosum and kaposi's sarcoma. cutaneous lesions can present months prior to other signs of systemic infection. | 1996 | 8624151 |
| human immunodeficiency virus and aids in uganda. | hiv-1 infection, initially described as "slim disease", was first recognized in uganda in 1982, and is now a predominant health problem. approximately 1.5 million ugandans are now infected, largely through heterosexual transmission. in many areas half of adult deaths are now caused by hiv. seroprevalence rates in urban antenatal clinics have been dropping in the last several years, as have rates in young adults in two rural community cohorts where the epidemic is long established. tuberculosis c ... | 1996 | 8625856 |
| human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of aids. | in this study the prevalence of human herpesvirus (hhv) 8 dna was determined in biopsies from persons with lymphoproliferative disorders and in peripheral blood mononuclear cells (pbmc) from human immunodeficiency virus (hiv)-seronegative and hiv-infected persons. the results show that hhv-8 is present in 10% of biopsies from hiv-seronegative persons: hhv-8 is detected with similar prevalence values in hiv-infected patients with lymphoproliferative diseases, but the virus load is higher. hhv-8 w ... | 1996 | 8627015 |
| kaposi's sarcoma: advances and perspectives. | kaposi's sarcoma (ks) is an unusual neoplasm that has proved to be an enigma in many ways since its original description by kaposi in 1872. its epidemiology has stimulated tremendous interest, amplified markedly in 1981 when it became known as an original defining part of the complex of immune disorders now known as aids. the cell of origin, etiology, and therapy for both aids-associated and aids-unassociated ks continue as matters of intense investigation. in fact, whether it is a reactive hype ... | 1996 | 8632078 |
| intralesional vinblastine injections for the treatment of oral kaposi's sarcoma: report of 10 patients with 2-year follow-up. | this study evaluated the use of intralesional vinblastine injections for the treatment of the intraoral lesions of kaposi's sarcoma. | 1996 | 8632242 |
| frequency and distribution of herpesvirus-like dna sequences (kshv) in different stages of classic kaposi's sarcoma and in normal tissues from an italian population. | the frequency and distribution of herpesvirus-like dna sequences (kshv) were investigated by pcr in the pathologic skin lesions of a series of 22 hiv-negative elderly patients with classic kaposi's sarcoma (ks) from italy, one of the few regions of the world where classic ks is prevalent. viral sequences were clearly identifiable in 15 cases, in particular in 2 of 5 patch, in 3 of 6 plaque and in 10 of 11 nodular lesions. our findings confirm the association of these herpesvirus-like dna sequenc ... | 1996 | 8635855 |
| detection and sequence analysis of a new herpesvirus-like agent in aids and non-aids kaposi's sarcoma in taiwan. | a new herpesvirus-like dna sequence (kshv) has been recently identified in kaposi's sarcoma from acquired immunodeficiency syndrome (aids) and non-aids patients. in order to verify the role of this new viral agent in taiwan, a series of kaposi's sarcoma specimens obtained from aids and non-aids patients in three medical centers representing different geographic locations of taiwan were surveyed. a total of seven specimens from aids patients and 22 specimens from non-aids patients were tested for ... | 1996 | 8640089 |
| [human herpesvirus 8]. | human herpesvirus 8 (hhv-8, kshv) was discovered in 1994 by means of a molecular biology approach which permitted to characterize fragments of its genomic sequence. the partial analysis of nucleotide sequence showed that hhv-8 was closely related to herpesvirus saimiri and epstein-barr virus, two members of gammaherpesvirinae sub-family. so far, the virus has been neither isolated nor observed using electron microscopy. it is only detected by means of polymerase chain reaction (pcr) and molecula ... | 1996 | 8640314 |
| combination chemotherapy with doxorubicin, bleomycin, and vindesine for aids-related kaposi's sarcoma. | kaposi's sarcoma is the most common neoplasm in patients with human immunodeficiency virus (hiv) infection. although the best therapeutic approach is still unclear, patients with advanced ks are usually treated with systemic chemotherapy. | 1996 | 8640679 |
| herpesvirus-like dna sequences and kaposi's sarcoma: relationship with epidemiology, clinical spectrum, and histologic features. | the evidence of an infectious agent other than human immunodeficiency virus (hiv) acting as a possible etiologic cause of kaposi's sarcoma (ks) has received considerable attention in the last years. recently, dna sequences from a new herpesvirus (hhv-8) have been observed in several cases of ks. the discovery suggests that this virus may play a role in the pathogenesis of ks. to evaluate these results, we determined the frequency of hhv-8 dna sequences in 78 specimens of ks according to differen ... | 1996 | 8640682 |
| human herpesvirus-8/kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects b cells. | herpesviral dna fragments isolated from aids-associated kaposi's sarcoma (ks) tissue (kshv-dna) share homology with two lymphotropic oncogenic gamma-herpesviruses, epstein-barr virus and herpesvirus saimiri, and are present in the lesions of more than 95% of hiv and non-hiv-associated forms of ks, aids-related body cavity-based lymphomas, and aids-related multicentric castleman's disease. here we show that bc-1, a kshv-dna-positive, body cavity-based lymphoma cell line, produces infective herpes ... | 1996 | 8642350 |
| kaposi's sarcoma with an intense parasitization by leishmania. | visceral leishmaniasis has been reported as a complication in patients infected with human immunodeficiency virus (hiv) who live in areas where leishmaniasis is endemic or in patients who have traveled to these areas. kaposi's sarcoma has been found frequently in patients with acquired immunodeficiency syndrome (aids). we report a hiv-infected patient having visceral leishmaniasis associated with kaposi's sarcoma in which a biopsy specimen obtained from a pigmented cutaneous lesion revealed the ... | 1996 | 8646853 |
| latent bk virus infection and kaposi's sarcoma pathogenesis. | we have analyzed by pcr skin lesions from classic, endemic and aids-related kaposi's sarcoma (ks), as well as from ks-derived cell lines, the presence of ubiquitous transforming viruses. bk virus (bkv), a transforming human papovavirus which has been associated with human tumors, was detected in 100% of ks skin lesions and 75% of ks cell lines. ks specimens contained a full-length, intact bkv early region, but minor rearrangements were observed in some tumors. bkv was also detected with a high p ... | 1996 | 8647638 |
| use of antiherpes drugs and the risk of kaposi's sarcoma: data from the multicenter aids cohort study. | to determine if use of antiherpes drugs protects against the development of aids-associated kaposi's sarcoma (ks), data from 935 homosexual men with aids from the multicenter aids cohort study were analyzed. in nested case-control analysis, neither acyclovir use for human immunodeficiency virus infection (odds ratio [or], 0.84; 95% confidence interval [ci], 0.56-1.26; p = .39) nor acyclovir use for any indication (or, 1.02; 95% ci, 0.76-1.38; p = .89) was associated with a reduced risk of ks as ... | 1996 | 8648224 |
| kaposi's sarcoma-associated herpesvirus (kshv or hhv8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells. | recent molecular evidence suggests an association with a new herpesvirus, kaposi's sarcoma-associated herpesvirus (kshv/hhv-8), and primary effusion lymphomas (pels). pels have a characteristic morphology, phenotype, and clinical presentation, with malignant effusions in the absence of a contiguous solid tumor mass. we have established a cell line (ks-1) from a kshv-positive human immunodeficiency virus (hiv)-negative patient with pleural cavity-based lymphoma that was passaged into triple-immun ... | 1996 | 8652805 |
| autopsy findings in patients with human immunodeficiency virus infection with emphasis on the risk factor of hemophilia. | the autopsy findings of 80 human immunodeficiency virus (hiv)-infected adults, who died between 1982-1995, are presented with special emphasis on the risk factor of hemophilia. the study included 23 blood product recipients (hemophiliacs n = 21; non-hemophiliacs n = 2), 34 homosexuals, four intravenous drug abusers, and 19 patients with no known risk factor. nearly all individuals (93%) showed the late stage of acquired immunodeficiency syndrome (aids). blood product recipients had a significant ... | 1996 | 8780928 |
| the role of human herpesvirus 8 and epstein-barr virus in the pathogenesis of giant lymph node hyperplasia (castleman's disease). | 1996 | 8783733 | |
| kaposi's sarcoma-associated herpesvirus dna sequences in aids-related and aids-unrelated lymphomatous effusions. | primary effusions presenting as the sole lymphoma localization are also known as body-cavity-based-lymphoma (bcbl), and have been shown to carry kaposi's sarcoma herpesvirus (kshv) dna sequences. the aim of this study was a comparative analysis of the clinical, pathologic and molecular features of bcbl and lymphomatous effusions secondary to tissue-based lymphomas occurring both in the general population and in hiv-1-infected individuals. all the lymphomatous effusion samples (seven aids-related ... | 1996 | 8790156 |
| a bivariate parametric model for survival and intermediate event times. | in diseases such as acquired immune deficiency syndrome (aids), there is great interest in describing the frequency of secondary diagnoses that occur during the course of the disease and their effect on survival. casting this situation in a more general framework, one distinguishes a terminal event (te) and an intermediate event (ie) that may or may not occur. in epidemiologic applications the te is usually death. earlier studies of ie and te times have used the latter to censor the ie time for ... | 1996 | 8804146 |
| viruses in the pathogenesis of kaposi's sarcoma--a review. | kaposi's sarcoma (ks) is the most frequent malignancy in aids patients. epidemiological studies indicate that a sexually transmitted infections agent other than hiv is involved in the evolution of ks. this "ks agent" may induce a cascade of cytokines which promote the development of the tumor in an autocrine and paracrine mechanism. in this review article several viruses, especially the recently discovered kaposi's sarcoma herpesvirus (kshv or hhv-8), are discussed as possible ks agents, and dif ... | 1996 | 8809339 |
| pathogenesis of aids--related kaposi's sarcoma. | the occurrence of kaposi's sarcoma (ks) in patients with hiv infection is more than 7,000 times higher than in the non-hiv infected population. the reason for this association is unclear but may involve decreased immune surveillance as a result of the profound cellular immune deficiency caused by hiv, a sexually transmitted ks-inducing virus, whose ks-transforming capabilities may be enhanced by hiv, or a direct or indirect effect of hiv itself in susceptible individuals. over the last few years ... | 1996 | 8820448 |
| antibodies to human herpesvirus type 8 in the general population and in kaposi's sarcoma patients. | much of the evidence that human herpesvirus type 8 (hhv-8) is associated with kaposi's sarcoma (ks) has come from molecular studies of hhv-8 dna. seroepidemiological studies have been hampered by the lack of a reliable assay. | 1996 | 8826812 |
| kaposi's sarcoma-associated herpesvirus infection prior to onset of kaposi's sarcoma. | kaposi's sarcoma-associated herpesvirus (kshv), a newly discovered human gammaherpesvirus, is found in the majority of ks lesions from patients with and without aids. peripheral blood mononuclear cells (pbmc) were examined for kshv dna to determine whether viral infection precedes onset of this neoplasm. | 1996 | 8838705 |
| establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (bc-3) harboring kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) in the absence of epstein-barr virus. | the recently identified kaposi's sarcoma-associated herpesvirus (kshv), also known as human herpesvirus 8 (hhv-8), has been found to be consistently associated with an unusual subset of acquired immunodeficiency syndrome-related lymphomas, the so-called body cavity-based lymphomas (bcbl) or primary effusion lymphomas (pel). these lymphomas are characterized by a unique spectrum of morphologic and molecular characteristics, and grow as lymphomatous effusions without an identifiable contiguous tum ... | 1996 | 8839859 |
| kaposi's sarcoma herpesvirus-like dna sequences in the saliva of individuals infected with human immunodeficiency virus. | 1996 | 8842293 | |
| molecular heterogeneity of b-lineage diffuse large cell lymphoma. | b-lineage diffuse large cell lymphoma (b-dlcl) arising de novo is characterized by a marked degree of clinical heterogeneity. to determine whether or not the clinical heterogeneity of de novo b-dlcl is reflected by heterogeneity in the molecular features of these tumors, we investigated the pattern of distribution of several genetic lesions in 70 cases of de novo b-dlcl at diagnosis. the panel of genetic lesions tested comprised the molecular alterations most frequently detected in b-dlcl, inclu ... | 1996 | 9162193 |
| pathology of acquired immunodeficiency syndrome (aids) in children. | overview: acquired immunodeficiency syndrome (aids) was first described to occur in children in 1983. with experience of increasing number of cases of aids, pathologic lesions in various organs and tissues such as lungs, brain, g.i. tract, heart, blood vessels, lymph nodes, spleen, bone marrow, etc. became evident in autopsy and biopsy specimens. these pathologic lesions were classified into four groups based on known or suspected pathogenesis: 1) primary lesions due to human immunodeficiency (h ... | 1996 | 9023448 |
| [kaposi sarcoma and human herpes virus type 8: recent data]. | 1996 | 9026586 | |
| the epidemiologic scope of kaposi's sarcoma. | the unique epidemiology of kaposi's sarcoma among patients with the acquired immunodeficiency syndrome suggests a multifactorial cause. although the human immunodeficiency virus (hiv) plays a major role in the pathogenesis of this condition, it is not the sole cause. other factors, such as a second sexually transmitted organism, genetics, and nitrite inhalant use, may predispose hiv-infected persons to kaposi's sarcoma. | 1996 | 16871704 |
| pharmacology of liposomal daunorubicin and its use in kaposi's sarcoma. | in the early 1980s, we first began to see cases of kaposi's sarcoma (ks) in patients with the lymphadenopathy now known to be associated with infection by the human immunodeficiency virus (hiv). during that period, we were still looking at strong combinations of chemotherapeutic drugs to combat this disease, based on experience in nonimmunosuppressed african patients. it rapidly became apparent, however, that we needed both better regimens and more efficient ways of targeting antineoplastic agen ... | 1996 | 16871707 |
| new developments: a look to the future. | inflammatory cytokines plus the human immunodeficiency virus tat protein apparently trigger the development of early kaposi's sarcoma. activated spindle cells provide a self-perpetuating, autocrine-supported mechanism for further development of hyperplastic lesions. in more advanced stages, a true neoplastic process may develop. | 1996 | 16871708 |
| malignancy in renal transplant recipients. | immunosuppressed organ allograft recipients have a 3-4 fold increased risk of developing cancer, but the chance of developing certain malignancies is increased several hundredfold. with the exception of skin cancers, most of the common neoplasms seen in the general population are not increased in incidence in organ allograft recipients. instead, there is a higher frequency of relatively rare tumors including lymphomas, kaposi's sarcoma, other sarcomas, vulvar and perineal carcinomas, renal and h ... | 1996 | 18417907 |
| lymphotropic herpes virus (ebv, hhv-6, hhv-8) dna sequences in hiv negative castleman's disease. | aim-to evaluate the possible involvement of lymphotropic herpes viruses in castleman's disease.methods-archival formalin fixed, paraffin wax embedded biopsy specimens from 16 hiv negative patients (11 with localised and five of multicentric disease) were studied. epstein-barr virus (ebv), human herpes virus-6 (hhv-6) and human herpes virus-8 (hhv-8) dna was detected using pcr. pcr was also used to characterise the ebv genomes and the clonal status of the lesions.results-ebv sequences were identi ... | 1996 | 16696081 |
| oncogenesis in hiv-infection. | the presence of human kaposi's sarcoma associated herpesvirus-like sequences (kshv) was examined in different epidemiological variants of kaposi's sarcoma (ks) and in ks-derived cell cultures by polymerase chain reaction (pcr). kshv dna was present in all tumor biopsies of aids-associated ks (59 biopsies), endemic ks (26 biopsies; 21 african endemic ks, 5 greek endemic ks), sporadic/classical ks (28 biopsies) and post-transplant/iatrogenic ks (6 of 7 biopsies). on the contrary, these sequences w ... | 1996 | 21541473 |
| detection of herpesvirus-like dna sequences in mediterranean kaposi's sarcoma. | the aetiology of kaposi's sarcoma remains obscure, however, epidemiological studies indicate that the disease possesses an infectious aetiology. recent data revealed the presence of specific herpesvirus-like dna sequences (khsv) in all forms of kaposi's sarcoma indicating that a novel virus may be the infectious agent which causes the disease. the aim of the present investigation was to assess the incidence of this herpesvirus-like dna sequence in 28 mediterranean kaposi's sarcomas. dna was extr ... | 1996 | 21594372 |
| medical microbiology | in nature, herpesviruses infect both vertebrate and non-vertebrate species, and over a hundred have been at least partially characterized. only eight of these have been isolated routinely from humans and are discussed here. they are known as the human herpesviruses and are herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, cytomegalovirus, epstein-barr virus, human herpesvirus 6, human ... | 1996 | 21413307 |
| pathogenesis of aids-related kaposis-sarcoma - (review). | kaposi's sarcoma (ks) was described as a clinical marker in some of the first identified cases of acquired immunodeficiency syndrome (aids) in the usa, and remains the most common tumor associated with human immunodeficiency virus (hiv) infection. the ks lesion contains several cell types, including spindle and endothelial, which express surface markers consistent with vascular, lymphatic or smooth muscle lineages. the growth characteristics of ks in vivo and in vitro are influenced by an array ... | 1995 | 21597734 |
| dermatological manifestations of human immunodeficiency virus infected / acquired immunodeficiency syndrome patients in a referral hospital of central kerala. | a number of skin diseases are described in association with hiv infection/aids. in the present study the frequency of various skin manifestations among hiv infected / aids patients are noted. generalised pruritus and dry skin were the common manifestations encountered. there was a significant absence of kaposi's sarcoma, multi-dermatomal herpes zoster and oral hairy leukoplakia. a prominent hyperpigmented band on finger nails was seen. | 1995 | 20952899 |
| the noninfectious respiratory complications of infection with hiv. | infection with hiv was first recognized through a clustering of unusual respiratory infections. the lung has been a major target manifesting many of the infectious complications of the immunodeficiency. noninfectious pulmonary complications in hiv-infected individuals are also common and have been recognized since the advent of the aids epidemic. malignancies involving the respiratory system, specifically kaposi's sarcoma and non-hodgkin's lymphoma, are epidemiologically linked to infection with ... | 1995 | 9363057 |
| prevalence of skin disease in patients infected with human immunodeficiency virus in bangkok, thailand. | a detailed study of the skin lesions of 248 patients infected with the human immunodeficiency virus (hiv) in bangkok, thailand, is reported. the study population consisted of 140 patients with asymptomatic disease (stage i), 27 patients with symptomatic disease (stage ii), and 81 patients with advanced stage of the disease (stage iii). ninety-five percent of all patients were observed to have one or more skin disorders. conditions with prevalence higher than 5% included oral candidiasis (34.3%), ... | 1995 | 8849182 |
| herpesvirus-like dna sequences in classic kaposi's sarcomas. | kaposi's sarcoma (ks) accounts for more than 15% of aids-related malignancies. the etiology of ks is unresolved but is postulated to be multifactorial, involving viruses and overexpression of cellular growth factors and/or oncogenes. recently, herpesvirus-like sequences (kshv) were identified with high prevalence in aids-ks (aks), endemic ks, and in classic ks biopsies (cks). to confirm the presence and the prevalence of the kshv sequences, 18 cks and 13 aks samples were tested using polymerase ... | 1995 | 8830123 |
| human herpesvirus-8: detection of novel herpesvirus-like dna sequences in kaposi's sarcoma and other lesions. | kaposi's sarcoma (ks) is a malignancy suspected of having an infectious etiology. unique viral dna sequences were recognized in ks lesions, using a novel technique that identifies small differences between two complex genomes. the virus had homology with the herpesvirus family, especially epstein barr virus (ebv), yet it was distinct from the known herpesviridae, and was appropriately named human herpesvirus 8 (hhv-8) or kaposi's sarcoma-associated herpesvirus (kshv). hhv-8 dna sequences were pr ... | 1995 | 8825757 |
| epidemiology of classic kaposi's sarcoma, with special reference to mediterranean population. | an excess of classic kaposi's sarcoma (ks) in individuals of southern european ancestry has long been suspected and recently quantified in terms of age-standardized rates. in italy and most notably in southern italy for the period 1976-84, prior to the aids epidemic, ks incidence rates were two-to-three-fold higher than in the united states and sweden and many ten-fold higher than in england and wales and australia. a high frequency of classic ks has also been documented in israel and, in low-ri ... | 1995 | 8804445 |
| [differential radiologic diagnosis of hiv-associated lung diseases]. | in 1993 in germany an estimated number of 50,000-70,000 individuals were infected with the human immunodeficiency virus (hiv), who estimations ranged up to 14 million hiv-positive individuals including 1 million children. aids-related diseases frequently occur in the lung. 65% of all aids-defining illnesses begin with life-threatening pulmonary infections. most frequently hiv-positive patients present with pneumocystis carinii pneumonia, followed by atypical mycobacteriosis, bacterial infections ... | 1995 | 8653002 |
| paclitaxel: current developmental approaches of the national cancer institute. | national cancer institute studies are addressing important issues in the development of paclitaxel (taxol; bristol-myers squibb company, princeton, nj), including optimal dose and schedule, the development of combination chemotherapy and multimodality regimens, and the evaluation of paclitaxel-containing therapy as front-line and adjuvant treatment. phase iii trials are ongoing in ovary, breast, lung, and head and neck cancers. broad phase ii testing of paclitaxel is nearing completion. recent i ... | 1995 | 8643972 |
| cholecystectomy in patients with aids: clinicopathologic correlations in 107 cases. | the etiologic and clinical features of cholecystisis in infection due to human immunodeficiency virus (hiv) were studies retrospectively. the charts and histopathologic specimens of 136 hiv-infected patients who underwent cholecystectomy between february 1987 and may 1993 at a large tertiary care center were reviewed. opportunistic pathogens infecting the 107 patients with aids included microsporidia (eight cases-- enterocytozoon bieneusi in six and septata intestinalis in two); cytomegalovirus ... | 1995 | 8645829 |
| [lymphoproliferative disease and cancer in the transplant patient]. | according to the spanish cardiac transplantation registry, malignant neoplasm remain the fifth leading cause of death in heart transplant recipients. skin cancers are the most common malignancies and they are frequently associated to solar keratosis, warts and keratoacanthoma. geographic areas are high cumulative ultraviolet exposure have a greater incidence of skin cancer. skin tumors are often located in chronically sun-exposed areas of the body. lymphoproliferative disorders are the second mo ... | 1995 | 8775827 |
| [the value of conventionally fractionated radiotherapy in the local treatment of hiv-related kaposi's sarcoma]. | during the course of aids, 25 to 44% of homosexual patients infected with the human immunodeficiency virus develop kaposi's sarcoma. main manifestation is the skin. response rates of 80 to 100% can be achieved with total dosage up to 50 gy. nevertheless, remissions can also be attained with 20 gy of fractionated radiotherapy. as clinical data on low dose conventional fractionated radiotherapy are insufficient we analysed the response rates of an overall dose of 20 gy in conventional fractionatio ... | 1995 | 8571179 |
| [kaposi's sarcoma in dermatology consultations at lome, togo]. | the purpose of this retrospective study conducted in a dermatologic out patient clinic in lomé was to assess the epidemiologic, clinical, and prognostic profile of kaposi's sarcoma in togo during the 15 years period between 1980 and 1994. only patients who had undergone serologic tests for human immunodeficiency virus (hiv) were included. there were 30 patients (27 men and 3 women) with a mean age of 35.2 years (range: 17 to 59 years). thirteen patients were seropositive (epidemic kaposi's sarco ... | 1995 | 8559021 |
| herpesvirus infections in persons infected with human immunodeficiency virus. | herpesviruses are among the most common causes of infections of humans. viruses in this family share the unique biological property of being able to establish latency and to recur. furthermore, chronic excretion of virus is not uncommon. in the immunocompromised host, including persons with human immunodeficiency virus (hiv) infection, herpesvirus disease can be particularly severe, resulting in chronic, persistent, active infection and, in some cases, life-threatening disease. the most pathogen ... | 1995 | 8547499 |
| influence of hiv epidemic on the incidence of kaposi's sarcoma in zambian children. | acquired immunodeficiency syndrome-associated kaposi's sarcoma (ks) is well documented in adults. however, very little information is available about ks in the pediatric age group. a retrospectively study was undertaken at the university teaching hospital (uth), lusaka, zambia, to define the incidence and clinical profile of ks in zambian children over the last 13 years and to determine the influence, if any, of the current human immunodeficiency virus (hiv) epidemic on the pattern of pediatric ... | 1995 | 8548353 |
| treatment of kaposi's sarcoma with liposomal doxorubicin. | the efficacy of liposomal doxorubicin for treating kaposi's sarcoma (ks) in patients infected with human immunodeficiency virus (hiv) was studied. eight men with hiv infection and ks were to be given liposomal doxorubicin 20 mg/sq m i.v. monthly for six months and 10 mg/sq m i.v. monthly thereafter, depending on the response. they were assessed for the onset, extent, and duration of clinical response; relapse; adverse effects; development of new opportunistic infections; quality of life; and sur ... | 1995 | 8528867 |
| treatment strategies for epidemic kaposi's sarcoma. | as the aids epidemic progresses, kaposi's sarcoma continues to contribute substantially to the morbidity suffered by aids patients. advances in our understanding of the pathogenesis of kaposi's sarcoma have resulted in treatment strategies that are being investigated in the laboratory and clinic. agents that affect the abnormal cytokines associated with kaposi's sarcoma or inhibit angiogenesis are in early clinical trials. the recent discovery of a putative kaposi's sarcoma virus may lead to new ... | 1995 | 8541388 |
| sarcomas in organ allograft recipients. | in a review of 8724 de novo malignancies that occurred in 8191 organ allograft recipients sarcomas were 7.4% of cancers. kaposi's sarcoma (ks) made up 5.7%, and other sarcomas (os) 1.7% a much higher proportion than in the general population. ks was most common in arab, black, italian, jewish, or greek patients. in 60% of patients with ks the lesions were confined to the skin and/or oropharynx while 40% involved internal organs and/or lymph nodes. complete remissions following various treatments ... | 1995 | 8545879 |
| human herpesvirus-like nucleic acid in various forms of kaposi's sarcoma. | the association between a new human herpesvirus-like agent and various forms of kaposi's sarcoma was examined by pcr. the dna sequences of this agent were detected in 7 of 8 classic kaposi's sarcoma specimens, 12 of 12 aids-associated specimens from the united states, and 7 of 10 specimens from african endemic kaposi's sarcoma. polymorphism of the herpesvirus-like dna in the kaposi's tissue from different populations was observed by both single-strand conformational polymorphism and direct seque ... | 1995 | 7891487 |
| cutaneous cryptococcosis and kaposi's sarcoma occurring in the same lesions in a patient with the acquired immunodeficiency syndrome. | a 34-year-old woman presented with a history of fever, malaise and skin lesions. a diagnosis of kaposi's sarcoma and acquired immunodeficiency syndrome (aids) was established, and in addition, the skin lesion which was biopsied also demonstrated cryptococcal infection. disseminated cryptococcosis was later confirmed and the disease ran a florid course. the co-existence of different diseases within the same lesion is a feature of human immunodeficiency virus (hiv) infection, this being the third ... | 1995 | 8857342 |
| primary intraosseous kaposi's sarcoma of the maxilla in human immunodeficiency virus infection: review of literature and report of case. | 1995 | 7532218 | |
| cytokines from activated t cells induce normal endothelial cells to acquire the phenotypic and functional features of aids-kaposi's sarcoma spindle cells. | kaposi's sarcoma (ks) is a proliferative disease of vascular origin particularly frequent in hiv-1-infected homosexual men (aids-ks) and characterized by proliferating spindle-shaped cells, angiogenesis, and inflammatory cell infiltration. previous work has suggested that ks spindle cells are of endothelial cell origin and that chronic immune activation via the release of inflammatory cytokines may cooperate with basic fibroblast growth factor (bfgf) and the hiv-1 tat protein in the induction an ... | 1995 | 7535796 |
| development of lymphoid hyperplasia in transgenic mice expressing the hiv tat gene. | during hiv infection, individuals experience multiorgan disorders such as adenopathy, splenomegaly, and lung and brain diseases. there is an increasing body of evidence that the hiv trans-activating tat gene product possesses multiple activities. first, it can activate several cellular genes; second, in its extracellular soluble form, it plays the role of growth factor in some cells such as kaposi's sarcoma cells. thus, we introduced the hiv tat gene, under the control of the cellular proteolipo ... | 1995 | 7537511 |
| kaposi's sarcoma: a reevaluation. | kaposi's sarcoma (ks) is a multicentric neoplasia of microvascular origin arising during development of immunodeficiency in human immunodeficiency virus (hiv)-infected individuals. more than 130 patients with hiv-associated ks (98% male homosexuals; median age, 35 years) have been diagnosed at the department of dermatology, university medical center steglitz, berlin, during the years 1982-1992. mucocutaneous and visceral involvement was a common finding in patients with hiv-associated ks, increa ... | 1995 | 7541146 |
| the hiv-1 tat protein induces the expression and extracellular appearance of acidic fibroblast growth factor. | mounting experimental evidence suggests that the tat protein, released from human immunodeficiency virus-1 (hiv-1)-infected inflammatory cells, may genetically reprogram targeted cells within a localized environment to develop highly vascularized tumors of mesenchymal origin. the fibroblast growth factor (fgf) family of polypeptides has gained general acceptance as initiators of angiogenesis and functions as potent mitogens for mesoderm-derived cells. to evaluate a potential biological relations ... | 1995 | 7542239 |
| is the human immunodeficiency virus-related kaposi's sarcoma epidemic coming to an end? insights from the tricontinental seroconverter study. | a decline in the proportion of kaposi's sarcoma among aids cases since the 1980s has been attributed to changes in sexual behavior among homosexual men and a decreasing exposure to a hypothesized kaposi's sarcoma cofactor. recent studies have shown that the incidence rate of kaposi's sarcoma has remained relatively stable, which seems to argue against the hypothesis of a declining exposure to the putative cofactor. to examine this paradox, we evaluated the incidence of kaposi's sarcoma, using co ... | 1995 | 7548345 |
| an autocrine loop of hiv type-1 tat protein responsible for the improved survival/proliferation capacity of permanently tat-transfected cells and required for optimal hiv-1 ltr transactivating activity. | human immunodeficiency virus type 1 (hiv-1) transactivating tat protein is pivotal to virus replication. tat's potential effects on hiv-1 pathogenesis, however, go well beyond its role in the virus's life cycle. current data indicate that biologically active tat is released from hiv-1-infected cells and readily endocytosed and targeted to the nucleus of nearby, or perhaps distant, cells, where it may exert a series of pleiotropic effects. this paracrine action has been extensively investigated, ... | 1995 | 7552492 |
| cutaneous manifestations of opportunistic infections in patients infected with human immunodeficiency virus. | bacillary angiomatosis (ba) presents most commonly as a cutaneous disease and is caused by two organisms. bartonella (rochalimaea) henselae and bartonella (rochalimaea) quintana. biopsy confirmation of cutaneous ba is essential because lesions can mimic nodular kaposi's sarcoma in appearance. although the vast majority of human immunodeficiency virus (hiv)-infected patients with ba have cd4 lymphocyte counts of less than 100 cells per mm3, the disease responds well to antimicrobial therapy. stap ... | 1995 | 7553576 |
| detection of several types of human papilloma viruses in aids-associated kaposi's sarcoma. | epidemiological studies indicate that acquired immunodeficiency syndrome (aids)-associated kaposi's sarcoma (ks) may be caused by an infectious, preferentially sexually transmitted agent. infections with human papilloma viruses are common, sexually transmitted diseases occurring frequently in homosexual men, who are also the main risk group for developing ks. in order to evaluate the possible role of hpv in the development of ks, 24 cutaneous aids-associated kaposi's sarcomas were investigated b ... | 1995 | 7561788 |
| immunocytochemistry of kaposi's sarcoma-like tumor cells from pigtailed macaques with simian aids. | some macaques infected with srv-2 developed saids and rf, a kaposi's sarcoma (ks)-like tumor. we investigated the immunophenotypic markers of this saids-associated retroperitoneal fibromatosis (rf). rf tumor is characterized by proliferation of spindle cells accompanying inflammatory cell infiltrates, fibroblasts, and endothelial cells. rf spindle cells in tumor tissues revealed several immunobiologic characteristics similar to vascular smooth-muscle cells or myofibroblasts based on positive imm ... | 1995 | 7563010 |
| ability of primary care physicians to recognize physical findings associated with hiv infection. | to assess the ability of primary care physicians to identify physical findings associated with human immunodeficiency virus (hiv) infection. | 1995 | 7563564 |
| childhood cancers in zambia before and after the hiv epidemic. | human immunodeficiency virus (hiv) related cancers in children are not as common and as well described as in adults. an hiv epidemic has been prevalent in zambia since 1983-1984. to study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the university teaching hospital (uth), lusaka, zambia. all the histopathological records from 1980 to 1992 were reviewed and all cases of cancers in children less than 14 years of age were analysed. in ... | 1995 | 7574850 |
| prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity. | ten adult patients with human immunodeficiency virus (hiv)-associated malignancies (five with lymphoma and five with kaposi's sarcoma) were treated with a daily subcutaneous injection of interleukin-2 (il-2) for 90 consecutive days in a phase i dose-escalation study. seven patients had absolute cd4 counts below 200/mm3 at the time malignancy was diagnosed. each lymphoma patient had obtained a complete or partial remission with standard chemotherapy before initiating il-2. the daily dose of il-2 ... | 1995 | 7579429 |
| kaposi's sarcoma in patients infected with human virus (hiv): an overview. | the emergence of kaposi's sarcoma (ks) among patients with hiv infection has raised a number of unsolved questions. the particular epidemiology and the etiology of ks remain unclear while both inflammatory cytokines and hiv-derived proteins appear to be involved in its pathogenesis as shown with the aid of in vitro ks-like cell cultures of animal models. since ks rarely occurs among hiv-positive caucasian females, sexual hormones, especially beta human chorionic gonadotropin, have recently been ... | 1995 | 7580828 |
| aids. viruses, cytokines and kaposi's sarcoma. | hiv infection strongly predisposes people to kaposi's sarcoma, a complex proliferative lesion driven by autocrine and paracrine cytokine expression; new evidence implicates a second virus in the etiology of the disease. | 1995 | 7583090 |
| a role for a new herpes virus (kshv) in different forms of kaposi's sarcoma. | kaposi's sarcoma (ks) is a previously rare, tumour-like lesion of controversial biological nature. ks has since the early 1980s become frequent in patients with aids, particularly in homosexuals. ks is also endemic in central africa predominantly in otherwise healthy men but also in women and children. recently, evidence for the presence of novel, herpes virus dna sequences in more than 90% of aids kaposi lesions (aks) was presented. this dna was identified using representational difference anal ... | 1995 | 7585156 |
| herpesvirus-like dna sequences in non-aids kaposi's sarcoma. | the pathogenesis of kaposi's sarcoma (ks) is suggested to be related to an infectious agent transmitted by sexual contact. recently, dna sequences homologous to gamma herpesviridae have been identified in aids-associated ks, but no information is available concerning non-aids-associated ks. five classic, 12 endemic, and 17 aids-associated ks skin lesion specimens were analyzed and all were positive for these novel dna sequences. twenty-four specimens from normal skin were negative. these novel s ... | 1995 | 7594727 |
| incidence of human immunodeficiency virus-related and nonrelated malignancies in a large cohort of homosexual men. | to determine if the rates of malignancies other than kaposi's sarcoma (ks) and non-hodgkin's lymphoma (nhl) are increased in human immunodeficiency virus (hiv)-infected homosexual men. | 1995 | 7595705 |
| testicular germ cell tumors and human immunodeficiency virus infection: a report of 26 cases. italian cooperative group on aids and tumors. | besides tumors that are diagnostic of aids, such as non-hodgkin's lymphoma, kaposi's sarcoma, and invasive carcinoma of the cervix, other tumors have been described in the human immunodeficiency virus (hiv) setting. some case reports on testicular cancer in hiv-infected patients have appeared in the literature. we present a retrospective study on 26 cases of testicular germ cell tumors (tgcts) observed within the italian cooperative group on aids and tumors (gicat) between november 1986 and sept ... | 1995 | 7595728 |
| perspectives of cytokine treatment in malignant skin tumors. | cytokines have been tested in the treatment of different skin cancers during the last decade, and treatment schedules have been established or proposed for several malignant skin tumors. preferentially, the interferons and interleukin-2 were found to be effective in treating skin cancers. interferons alpha and beta have been approved for the treatment of human immunodeficiency virus (hiv)-associated kaposi's sarcoma, cutaneous t cell lymphoma, and malignant melanoma in several countries. interfe ... | 1995 | 7597303 |
| management of human immunodeficiency virus-associated malignancies. | a number of malignancies which have been seen with other immunodeficiency diseases have appeared in patients immunosuppressed by the human immunodeficiency virus (hiv) infection. these include kaposi's sarcoma, lymphomas, superficially spreading basal cell carcinomas, and squamous cell carcinomas. the fact that kaposi's sarcoma is the most common of these malignancies and is seen almost exclusively among homosexual men remains an enigma. the dermatological treatment of kaposi's sarcoma includes ... | 1995 | 7597310 |
| new research suggests herpes virus may cause kaposi's sarcoma. | 1995 | 7608509 | |
| human immunodeficiency virus and the skin: selected controversies. | acquired immunodeficiency syndrome was first recognized as a new disease in 1981 because of the unusual association of kaposi's sarcoma and pneumocystis carinii pneumonia in young men. the skin remains one of the most important clinical markers for acquired immunodeficiency syndrome, now recognized as the end stage of infection with the human immunodeficiency virus (hiv). indeed, an urticarial viral exanthem appearing during seroconversion may allow early identification of newly infected individ ... | 1995 | 7615989 |
| molecular analysis of clonality in castleman's disease. | castleman's disease (cd) is a rare atypical lymphoproliferative disorder that is morphologically and clinically heterogenous and is associated with a risk of developing malignant lymphoma. we report the clonality status of cd tissues in 34 patients, including 14 patients infected by the human immunodeficiency virus (hiv). four patients presented a localized form and 30 presented a multicentric form. two cases were associated with b-cell lymphoma, 3 cases with hodgkin's disease, and 9 cases (8 hi ... | 1995 | 7620166 |
| [role of retroviruses in human cancerogenesis]. | retroviruses are viral agents which are natural and experimental inductors of leukemias and solid tumors among numerous animal species. in man, they are implicated as ethiological agents of a specific type of leukemia, adult-t cell leukemia. thus is for retrovirus htlv-i. another retrovirus, hiv, implicated in aids is capable of leading to the formation of several types of opportunistic tumors, such as non hodgkin lymphomas and kaposi's sarcoma. | 1995 | 7626863 |
| isolation and characterization of an immortal neoplastic cell line (ks y-1) from aids-associated kaposi's sarcoma. | acquired immunodeficiency syndrome (aids) is associated with the occurrence of tumors such as kaposi's sarcoma (ks) and b-cell lymphoma. however, no evidence exists yet that human immunodeficiency virus type 1, the causative agent of aids, is directly responsible for cell transformation. it is also not clear whether ks lesions, which are of complex cellularity, contain tumor cells derived from a true monoclonal malignancy (originating from a single malignant cell) or whether the lesions are just ... | 1995 | 7629884 |
| pleural effusions in human immunodeficiency virus-infected patients. correlation with concomitant pulmonary diseases. | the objective of our study was to evaluate the prevalence of pleural effusions in patients with the acquired immunodeficiency syndrome, to correlate these effusions with any concomitant pulmonary diseases and to evaluate the role of cytologic examination in the diagnosis of the effusions. twenty-eight of 389 (7.2%) human immunodeficiency virus-infected patients had pleural effusions and 27 of the 28 were suffering from concomitant pulmonary diseases. those diseases were bacterial pneumonia (9), ... | 1995 | 7631543 |
| kaposi's sarcoma-associated herpesvirus-like dna sequences in multicentric castleman's disease. | multicentric castleman's disease (mcd) is an atypical lymphoproliferative disorder defined using clinical and pathologic criteria. a characteristic of the mcd is a close association with kaposi's sarcoma (ks), which occurs during the clinical course of most human immunodeficiency virus (hiv)-associated mcd cases and also, but less frequently, in hiv-negative patients. recently, sequences of a putative new herpesvirus (kshv) have been isolated and further detected in almost all the acquired immun ... | 1995 | 7632932 |
| human herpesvirus type 6 and cytomegalovirus in aids-associated kaposi's sarcoma: no evidence for an etiological association. | epidemiological studies indicate that acquired immune deficiency syndrome (aids)-associated kaposi's sarcoma (ks) may be caused by an infectious, preferentially sexually transmitted agent. herpesviruses infections are common sexually transmitted diseases in homosexual men, who are also the main risk group for developing kaposi's sarcoma. to evaluate a possible role of human herpesvirus-6 (hhv-6) and cytomegalovirus (cmv) in the development of aids-associated ks, we investigated cutaneous aids-as ... | 1995 | 7635454 |