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conservation of wildlife populations: factoring in incremental disturbance.progressive anthropogenic disturbance can alter ecosystem organization potentially causing shifts from one stable state to another. this potential for ecosystem shifts must be considered when establishing targets and objectives for conservation. we ask whether a predator-prey system response to incremental anthropogenic disturbance might shift along a disturbance gradient and, if it does, whether any disturbance thresholds are evident for this system. development of linear corridors in forested ...201728649339
scavenging on a pulsed resource: quality matters for corvids but density for mammals.human food subsidies can provide predictable food sources in large quantities for wildlife species worldwide. in the boreal forest of fennoscandia, gut piles from moose (alces alces) harvest provide a potentially important food source for a range of opportunistically scavenging predators. increased populations of predators can negatively affect threatened or important game species. as a response to this, restrictions on field dressing of moose are under consideration in parts of norway. however, ...201728619108
enantioselectivity of anteiso-fatty acids in hitherto uninspected sample matrices.anteiso-fatty acids (afas) are chiral molecules due to a methyl substituent on the antepenultimate carbon of the otherwise straight acyl chain. 12-methyltetradecanoic acid (a15:0) and 14-methylhexadecanoic acid (a17:0) are the predominant afas in nature but their individual contributions e.g. to food lipids are usually low. enantioselective data has been collected in fish, bovine milk/cheese, and brussels sprouts. in this study, we determined the enantioselectivity of a15:0 and a17:0 in shea but ...201728753519
de novo comparative transcriptome analysis of genes involved in fruit morphology of pumpkin cultivars with extreme size difference and development of est-ssr markers.the genetic basis of fruit size and shape was investigated for the first time in cucurbita species and genetic loci associated with fruit morphology have been identified. although extensive genomic resources are available at present for tomato (solanum lycopersicum), cucumber (cucumis sativus), melon (cucumis melo) and watermelon (citrullus lanatus), genomic databases for cucurbita species are limited. recently, our group reported the generation of pumpkin (cucurbita pepo) transcriptome database ...201728435133
comparative metagenomics of cellulose- and poplar hydrolysate-degrading microcosms from gut microflora of the canadian beaver (castor canadensis) and north american moose (alces americanus) after long-term enrichment.to identify carbohydrate-active enzymes (cazymes) that might be particularly relevant for wood fiber processing, we performed a comparative metagenomic analysis of digestive systems from canadian beaver (castor canadensis) and north american moose (alces americanus) following 3 years of enrichment on either microcrystalline cellulose or poplar hydrolysate. in total, 9,386 genes encoding cazymes and carbohydrate-binding modules (cbms) were identified, with up to half predicted to originate from f ...201729326667
immunomodulatory treatments for persistent and chronic immune thrombocytopenic purpura: a prisma-compliant systematic review and meta-analysis of 28 studies.corticosteroid sparing is required in 15% to 40% of adults with persistent or chronic primary immune thrombocytopenic purpura (itp). herein, the efficacy of immunomodulatory drugs (dapsone, interferon alpha, danazol, and hydroxychloroquine as second-third-line therapies in itp is investigated.201728906353
association between mdm2 snp309, p53 arg72pro, and hepatocellular carcinoma risk: a moose-compliant meta-analysis.epidemiological studies have determined the associations between polymorphisms on the promoter of mdm2 (snp309) and the codon 72 on exon 4 of p53 (p53 arg72pro) and the risk of hepatocellular carcinoma (hcc); however, the results were not always consistent. the aim of the present meta-analysis was to evaluate the overall associations between these 2 variants and hcc risk.the medline, web of science, embase, cochrane library, and cnki databases were searched for eligibility studies and the data w ...201728885338
diabetes and pressure ulcer risk in hip fracture patients: a meta-analysis.the aim of this study was to assess the relationship between diabetes and pressure ulcer (pu) risk in patients with hip fractures.201728880760
rna-sequence data normalization through in silico prediction of reference genes: the bacterial response to dna damage as case study.measuring how gene expression changes in the course of an experiment assesses how an organism responds on a molecular level. sequencing of rna molecules, and their subsequent quantification, aims to assess global gene expression changes on the rna level (transcriptome). while advances in high-throughput rna-sequencing (rna-seq) technologies allow for inexpensive data generation, accurate post-processing and normalization across samples is required to eliminate any systematic noise introduced by ...201728878825
association of sleep-disordered breathing with cognitive function and risk of cognitive impairment: a systematic review and meta-analysis.growing evidence suggests an association between sleep-disordered breathing (sdb) and cognitive decline in elderly persons. however, results from population-based studies have been conflicting, possibly owing to different methods to assess sdb or cognitive domains, making it difficult to draw conclusions on this association.201728846764
hypofractionated radiation therapy for basal and squamous cell skin cancer: a meta-analysis.to characterize the cosmetic outcomes and local recurrence (lr) rates of various hypofractionated radiation therapy (rt) regimens for skin basal and squamous cell cancers (bccs/sccs).201728843727
association of androgen deprivation therapy and depression in the treatment of prostate cancer: a systematic review and meta-analysis.there is increasing evidence that androgen deprivation therapy (adt) may be associated with depression. existing studies have shown conflicting results.201728803700
time trends and exposure determinants of lead and cadmium in the adult population of northern sweden 1990-2014.this study follows cadmium and lead concentrations in blood in the adult population in northern sweden over 24 years.201728787621
incidence, prognostic factors and impact of postoperative delirium after major vascular surgery: a meta-analysis and systematic review.although postoperative delirium is a common complication and increases patient care needs, little is known about the predictors and outcomes of delirium in patients having vascular surgery. this review aimed to determine the incidence, prognostic factors and impact of postoperative delirium in vascular surgical patients. medline and embase were systematically searched for articles published between january 2000 and january 2016 on delirium after vascular surgery. the primary outcome was the inci ...201728784053
association between hiv infection and prevalence of erectile dysfunction: a systematic review and meta-analysis.the prevalence of erectile dysfunction (ed) in men positive for hiv has been reported to exceed the baseline of the general population. however, no meta-analysis or conclusive review has investigated whether individuals with hiv infection have a significantly higher prevalence of ed.201728778576
collaborative goal setting with elderly patients with chronic disease or multimorbidity: a systematic review.it is challenging to use shared decision-making with patients who have a chronic health condition or, especially, multimorbidity. a patient-goal-oriented approach can thus be beneficial. this study aims to identify and evaluate studies on the effects of interventions that support collaborative goal setting or health priority setting compared to usual care for elderly people with a chronic health condition or multimorbidity.201728760149
outcome of intracerebral haemorrhage related to non-vitamin k antagonists oral anticoagulants versus vitamin k antagonists: a comprehensive systematic review and meta-analysis.the characteristics and natural history of acute non-vitamin k antagonists oral anticoagulants (noac)-associated intracerebral haemorrhage (ich) are largely unknown. we performed a comprehensive systematic review and meta-analysis to compare baseline ich volume, haematoma expansion and clinical outcomes between noac-ich versus vitamin k antagonists-ich (vka-ich).201729030422
stoichiometric distribution models: ecological stoichiometry at the landscape extent.human activities are altering the fundamental geography of biogeochemicals. yet we lack an understanding of how the spatial patterns in organismal stoichiometry affect biogeochemical processes and the tools to predict the impacts of global changes on biogeochemical processes. in this contribution we develop stoichiometric distribution models (stdms), which allow us to map spatial structure in resource elemental composition across a landscape and evaluate spatial responses of consumers. we parame ...201729027338
the value of lncrna neat1 as a prognostic factor for survival of cancer outcome: a meta-analysis.the present meta-analysis aimed to analyze available data to identify the prognostic role of neat1 in multiple carcinomas. a systematic search was performed by using several computerized databases from inception to june 7, 2017. the quantity of the publications was assessed according to moose checklist. pooled hrs with 95% ci was calculated to summarize the effect. a total of 12 studies with 3,262 cancer patients were pooled in the analysis to evaluate the prognostic value of neat1 in multiple t ...201729026116
does caesarean section affect breastfeeding practices in china? a systematic review and meta-analysis.objectives to ascertain the association between caesarean delivery and breastfeeding practices in china. methods we conducted a systematic review and meta-analysis following the preferred reporting items for systematic reviews and meta-analyses (prisma) and meta-analysis of observational studies in epidemiology (moose) guidelines. electronic databases of cnki, medline, embase, cinahl, proquest and science direct were searched and screened to identify relevant articles from january 1990 to june 2 ...201729019000
inflammatory bowel disease and eating disorders: a systematized review of comorbidity.research has shown that there is an association between inflammatory bowel disease, anxiety and mood disorders, however little is known about their association with eating disorders. in this paper we will present a case of a young female with a comorbid diagnosis of inflammatory bowel disease and eating disorder, and then discuss the results from a systematic review of the literature, describing published cases of patients with the same condition.201728992897
association of krouse classification for sinonasal inverted papilloma with recurrence: a systematic review and meta-analysis.the risk factors for the recurrence of sinonasal inverted papilloma are still unclear.201728973390
long-term survival of women with breast cancer. overview supportive care needs assessment instruments.worldwide, breast cancer is the fifth leading cause of cancer death (after lung, stomach, liver and colon cancer), while among women it is first on the list. the incidence of breast cancer has made a dramatic increase since 1970 which is partly interpreted by the modern western life standards. the expected risk of breast cancer throughout a lifespan of an average is 1 in 11 women. the five-year survival rates for breast cancer are at 80% if it has not spread, and only at 40% for the metastatic t ...201728971436
the accuracy of the broselow tape as a weight estimation tool and a drug-dosing guide - a systematic review and meta-analysis.the broselow tape is widely used as a weight-estimation device and drug-dosing guide aid, but concerns about its accuracy and its efficacy have emerged in the last decade. the aim of this study was to systematically review the literature to analyse the accuracy of the broselow tape as a weight estimation device and review evidence of its utility as a drug-dosing guide.201728958796
modelling time to population extinction when individual reproduction is autocorrelated.in nature, individual reproductive success is seldom independent from year to year, due to factors such as reproductive costs and individual heterogeneity. however, population projection models that incorporate temporal autocorrelations in individual reproduction can be difficult to parameterise, particularly when data are sparse. we therefore examine whether such models are necessary to avoid biased estimates of stochastic population growth and extinction risk, by comparing output from a matrix ...201728925038
the use of the model of occupational self efficacy in improving the cognitive functioning of individuals with brain injury: a pre- and post-intervention study.individuals diagnosed with a traumatic brain injury (tbi) often experience major limitations in returning to work despite participating in rehabilitation programmes.201728922182
systematic review of nephrotoxicity of drugs of abuse, 2005-2016.the united states is faced with an unprecedented epidemic of drug abuse. every year thousands of americans visit the emergency departments all over the country with illicit drug related complaints. these drugs have been known to be associated with a range of renal pathologies, from reversible acute kidney injuries to debilitating irreversible conditions like renal infarction. so far, no comprehensive study or systematic review has been published that includes the commonly used street drugs and d ...201729287591
laparoscopic vs open hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a meta-analysis of the long-term survival outcomes.in patients with hepatocellular carcinoma (hcc) and cirrhosis, laparoscopic hepatectomy (lh) confers short-term benefits over open hepatectomy (oh) but the long-term outcomes of this procedure are unclear. this systematic review aims to compare the long-term survival outcomes of lh and oh for patients with hcc and underlying cirrhosis.201729284151
prevalence of work-related musculoskeletal disorders among surgeons and interventionalists: a systematic review and meta-analysis.physicians in procedural specialties are at high risk for work-related musculoskeletal disorders (msds). this has been called "an impending epidemic" in the context of the looming workforce shortage; however, prevalence estimates vary by study.201729282463
protocolized laboratory screening for the medical clearance of psychiatric patients in the emergency department: a systematic review.emergency department (ed) patients with psychiatric chief complaints undergo medical screening to rule out underlying or comorbid medical illnesses prior to transfer to a psychiatric facility. this systematic review attempts to determine the clinical utility of protocolized laboratory screening for the streamlined medical clearance of ed psychiatric patients by determining the clinical significance of individual laboratory results.201729266617
incidence of malignant hyperthermia in patients undergoing general anesthesia: protocol for a systematic review and meta-analysis.malignant hyperthermia (mh) continues to be of potential concern for clinicians whenever inhalational anesthetic agents or succinylcholine are used, because mh is a potentially fatal metabolic disorder.201729245345
the impact of human leukocyte antigen mismatching on graft survival and mortality in adult renal transplantation: a protocol for a systematic review and meta-analysis.human leukocyte antigen (hla) was important biological barrier to a successful transplantation. quantitative evaluations of the effect of hla mismatching on heart, liver, umbilical cord blood, and hematopoietic stem cell transplantation, have previously been reported. in new era of immunosuppression, the reported magnitude effect of hla mismatching on survival outcomes of kidney transplantation was controversial. in addition, the current kidney allocation guideline recommendations in different c ...201729245253
fitness correlates of age at primiparity in a hunted moose population.trade-offs between fitness-related traits are predicted from the principle of resource allocation, where increased fecundity or parental investment leads to reduced future reproduction or survival. however, fitness traits can also be positively correlated due to individual differences (e.g. body mass). age at primiparity could potentially explain variation in individual fitness either because early primiparity is costly, or it may lead to higher lifetime reproductive success. based on long-term ...201729197974
assessing health care access and use among indigenous peoples in alberta: a systematic review.alberta's indigenous population is growing, yet health care access may be limited. this paper presents a comprehensive review on health care access among indigenous populations in alberta with a focus on the health care services use and barriers to health care access. scientific databases (pubmed, embase, cinahl, and psycinfo) and online search engines were systematically searched for studies and grey literature published in english between 2000 and 2013 examining health care services access, us ...201729176095
duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis.previous reviews suggest there is minimal evidence for an association between duration of untreated psychosis (dup) and neurocognition. this is based on tallied findings of studies with small samples and neurocognition viewed as a single construct. we aimed to conduct a systematic review and meta-analysis examining the association between dup and individual neurocognitive domains and tests in first-episode psychosis (fep).201729173201
a systematic review and meta-analysis of lifestyle and body mass index predictors of successful assisted reproductive technologies.lifestyle (smoking, drinking alcohol) and body mass index (bmi) predictors of successful outcomes in assisted reproductive technology (art) treatments were examined in this meta-analysis.201729172958
cancer risk associated with nuclear atypia in cytologically indeterminate thyroid nodules: a systematic review and meta-analysis.indeterminate categories of thyroid cytopathology (categories b-iii and b-iv of the bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. it has been suggested that aspirates exhibiting nuclear atypia have a higher risk of malignancy. this study aimed to assess whether cytologically indeterminate thyroid nodules with nuclear atypia have a significantly higher cancer risk than those without nu ...201729160163
mapping the association between vitamin d and low back pain: a systematic review and meta-analysis of observational studies.low back pain (lbp) is the highest contributor to disability worldwide, with current intervention strategies only providing small to moderate analgesic effects. the use of vitamin d supplementation for lbp has gained interest due to its proposed anti-inflammatory and neuromodulatory properties. however, it is still unclear whether vitamin d levels differ between those with and without lbp or if vitamin d levels are associated with pain intensity.201729149142
occupational noise exposure and the risk for work-related injury: a systematic review and meta-analysis.occupational noise exposure has been linked to work-related injuries. strategies to control occupational hazards often rely on dose-response relationships needed to inform policy, but quantitative synthesis of the relevant literature has not been done so far. this study aimed to systematically review the epidemiological literature and to perform meta-analysis of the risk for work-related injury due to occupational noise exposure.201729136415
the quality of australian indigenous primary health care research focusing on social and emotional wellbeing: a systematic review.objectives and importance of the study: primary health care research focused on aboriginal and torres strait islander (indigenous) people is needed to ensure that key frontline services provide evidence based and culturally appropriate care. we systematically reviewed the published primary health care literature to identify research designs, processes and outcomes, and assess the scientific quality of research focused on social and emotional wellbeing. this will inform future research to improve ...201729114717
updating the "risk index": a systematic review and meta-analysis of occupational injuries and work schedule characteristics.fatigue is a major risk factor for occupational 'accidents' and injuries, and involves dimensions of physical, mental, and muscular fatigue. these dimensions are largely influenced by temporal aspects of work schedules. the "risk index" combines four fatigue-related components of work schedules to estimate occupational 'accident' and injury risk based on empirical trends: shift type (morning, afternoon/evening, night), length and consecutive number, and on-shift rest breaks. since its first intr ...201729064297
evidence for decreasing sperm count in african population from 1965 to 2015.this meta-analysis, following our previous reports those documented an overall 57% diminution in mean sperm concentration around the globe over past 35 years and 32.5% decline in past 50 years in european population, attempts to report the declining trend of sperm concentrations in african population between 1965 and 2015.201729062337
a systematic review of intrapartum fetal head compression: what is the impact on the fetal brain?objective during labor the fetal head is subjected to pressure related to uterine contractions and maternal pushing. here we systematically review what is known about fetal head compression and its effects on fetal intracranial pressure, oxygenation, blood flow and cerebral function, and the plausibility that it might cause isolated fetal brain injury. study design systematic review of intrapartum fetal head compression and fetal brain injury in accordance with the moose methodology. the pubmed ...201728465865
guidance in author instructions of hematology and oncology journals: a cross sectional and longitudinal study.the debate about the value of biomedical publications led to recommendations for improving reporting quality. it is unclear to what extent these recommendations have been endorsed by journals. we analyzed whether specific recommendations were included in author instructions, which journal characteristics were associated with their endorsement, how endorsement of the domains changed and whether endorsement was associated with change of impact factor between 2010 and 2015.201728453528
weekend versus weekday admission and short-term mortality: a meta-analysis of 88 cohort studies including 56,934,649 participants.it is widely accepted that higher mortality related to weekend admissions basically exists; however, there has been no systematic exploration of whether weekend admissions are associated with higher risk of death in patients on the basis of certain diagnoses, geographic regions, and study subtypes.a meta-analysis was performed according to the reporting guidelines of the meta-analysis of observational studies in epidemiology (moose compliant). literature search was conducted using electronic dat ...201728445269
intrauterine device survival in iranian women: systematic review and meta-analysis.the intrauterine device (iud) is one of the modern contraception methods that is reversible, safe, effective, and with long-term efficacy. the problem of using this method is early discontinuation. the survival of the iud use has been reported differently in different studies. in this meta-analysis, we estimated average time of surviving in iranian women.201725949968
childhood psychiatric disorders as risk factor for subsequent substance abuse: a meta-analysis.to assess the prospective risk of developing substance-related disorders after childhood mental health disorders (i.e., attention-deficit/hyperactivity disorder [adhd], oppositional defiant disorder [odd] or conduct disorder [cd], anxiety disorder, and depression) using meta-analysis.201728647007
a unique fatal moose attack mimicking homicide.fatalities caused by animal attacks are rare, but have the potential to mimic homicide. we present a case in which a moose attacked and killed a woman who was walking her dog in a forest. autopsy showed widespread blunt trauma with a large laceration on one leg in which blades of grass were embedded. flail chest was the cause of death. the case was initially conceived as homicide by means of a riding lawn mower. a review of the case by moose experts and analyses of biological trace material that ...201728631272
meta-analysis of determinants of survival following treatment of recurrent hepatocellular carcinoma.intrahepatic recurrence of hepatocellular carcinoma (hcc) following resection is common. however, no current consensus guidelines exist to inform management decisions in these patients. systematic review and meta-analysis of survival following different treatment modalities may allow improved treatment selection. this review aimed to identify the optimum treatment strategies for hcc recurrence.201728628947
prevalence, incidence and aetiologies of pulmonary hypertension in africa: a systematic review and meta-analysis protocol.there are no data summarising the epidemiology of pulmonary hypertension (ph) among adults residing in africa. establishment of accurate epidemiological data on ph in this region may guide decision-making toward interventions to curb the burden of ph in africa. the aim of this systematic review is to determine the prevalence, incidence and aetiologies of ph among people residing in africa.201728624758
association between chemokine cxc ligand 12 gene polymorphism (rs1746048) and coronary heart disease: a moose-compliant meta-analysis.recently a large number of investigations have implicated the association between the chemokine cxc ligand 12 gene polymorphism (rs1746048) and risk of coronary heart disease (chd), but the results remain debatable. the aim of our study was to provide more compelling evidence for the relationship between rs1746048 and chd risk. studies eligible for this meta-analysis were identified through electronic search of pubmed, embase, and cnki. two authors performed independent literature review and stu ...201728614256
psoriasis in latin america and the caribbean: a systematic review.psoriasis is a chronic inflammatory disease that generally affects the skin, nails and joints. the burden of psoriatic disease in latin america and the caribbean (lac) remains largely unknown. to estimate the burden of psoriasis in lac. we conducted a systematic review following the moose and prisma statements. we searched published studies in medline, embase, lilacs and central from 1st january 2000 to 5th august 2015. we included studies that reported incidence, prevalence, health resource use ...201728608530
eating frequency and weight and body composition: a systematic review of observational studies.the present review aimed to examine the association of eating frequency with body weight or body composition in adults of both sexes.201728578730
suicide rates after discharge from psychiatric facilities: a systematic review and meta-analysis.high rates of suicide after psychiatric hospitalization are reported in many studies, yet the magnitude of the increases and the factors underlying them remain unclear.201728564699
association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis.the etiologic factors of late-life depression are still poorly understood. recent evidence suggests that microvascular dysfunction is associated with depression, which may have implications for prevention and treatment. however, this association has not been systematically reviewed.201728564681
hysteroscopy in the treatment of uterine cesarean section scar diverticulum: a systematic review.the aim of this paper is to review and to analyze the results of previous studies dealing with hysteroscopic treatment of postcesarean scar defects. a systematic review of publications indexed in medline/pubmed database identified a total of 11 studies dealing with resectoscopic treatment of postcesarean scar defect. the review was conducted in line with the meta-analysis of observational studies in epidemiology (moose) guidelines and the prisma statement. in only few studies, patients were qual ...201728500899
transplacental transmission of neospora caninum in moose (alces alces).a 5-years-old moose (alces alces) cow kept in a zoo in the german federal state of brandenburg aborted a female foetus of 44cm crown rump length (crl). pathohistological analysis revealed several neospora (n.) caninum infected cells and cysts, as well as multifocal gliosis, necrosis, haemorrhages, dystrophic mineralisation and haemosiderosis in the brain, predominantly in cerebrum and brainstem. in addition, mild lymphocytic meningitis was present. together with the fresh foetus, a mummified foe ...201731014840
chronic wasting disease (cwd) in cervids.in april and may of 2016, norway confirmed two cases of chronic wasting disease (cwd) in a wild reindeer and a wild moose, respectively. in the light of this emerging issue, the european commission requested efsa to recommend surveillance activities and, if necessary, additional animal health risk-based measures to prevent the introduction of the disease and the spread into/within the eu, specifically estonia, finland, iceland, latvia, lithuania, norway, poland and sweden, and considering seven ...201732625260
temporal patterns of moose-vehicle collisions with and without personal injuries.collisions with wild ungulates are an increasing traffic safety issue in boreal regions. crashes involving smaller-bodied deer species usually lead to vehicle damage only, whereas collisions with a large animal, such as the moose, increase the risk of personal injuries. it is therefore important to understand both the factors affecting the number of moose-vehicle collisions (mvcs) and the underlying causes that turn an mvc into an accident involving personal injuries or fatalities. as a basis fo ...201727723518
correction: range expansion of moose in arctic alaska linked to warming and increased shrub habitat.[this corrects the article doi: 10.1371/journal.pone.0152636.].201727442025
association between antioxidant intake/status and obesity: a systematic review of observational studies.the global prevalence of obesity has doubled in recent decades. compelling evidences indicated that obesity was associated with lower concentrations of specific antioxidants which may play a role in the development of obesity-related diseases such as cardiovascular disease. the present review aimed to synthesize the evidence from studies on the association between obesity and antioxidant micronutrients in a systematic manner. data bases including medline, science direct, and cochrane were search ...201727334437
diagnosis of severe fetomaternal hemorrhage with fetal cerebral doppler: case series and systematic review.to analyze the role of middle cerebral artery (mca) peak systolic velocity (psv) in the prediction of severe fetomaternal hemorrhage (fmh) and to compare it with standard biophysical assessment.201727174184
dry matter and digesta particle size gradients along the goat digestive tract on grass and browse diets.physical properties of the digesta vary along the ruminant digestive tract. they also vary within the forestomach, leading to varying degrees of rumen contents stratification in 'moose-type' (browsing) and 'cattle-type' (intermediate and grazing) ruminants. we investigated the dry matter concentration (dm) and the mean digesta particle size (mps) within the forestomach and along the digestive tract in 10 goats fed grass hay or dried browse after a standardized 12-h fast, euthanasia and freezing ...201727016403
the impact of trunk impairment on performance of wheelchair activities with a focus on wheelchair court sports: a systematic review.trunk impairment seems to impact significantly on performance in wheelchair court sports, but evidence to support this impression has never been systematically assessed. the objective of this study is to systematically review, describe and synthesise the literature investigating the impact of trunk impairment on wheelchair activities in court sports.201726284163
migraine affects 1 in 10 people worldwide featuring recent rise: a systematic review and meta-analysis of community-based studies involving 6 million participants.to study the weighted average global prevalence of migraine at the community level.201728017235
risk of urinary retention after nerve-sparing surgery for deep infiltrating endometriosis: a systematic review and meta-analysis.recently, nerve-sparing (ns) techniques have been incorporated in surgeries for deep infiltrating endometriosis (die) to prevent urinary complications. our aim was to perform a systematic review and meta-analysis to assess the risk of urinary retention after ns surgery for die compared with classical (non-ns) techniques.201726479158
high prevalence of prion protein genotype associated with resistance to chronic wasting disease in one alberta woodland caribou population.chronic wasting disease (cwd) is a prion disease found in deer, elk and moose in north america and since recently, wild reindeer in norway. caribou are at-risk to encounter cwd in areas such as alberta, canada, where the disease spreads toward caribou habitats. cwd susceptibility is modulated by species-specific polymorphisms in the prion protein gene (prnp). we sequenced prnp of woodland caribou from 9 albertan populations. in one population (chinchaga) a significantly higher frequency of the 1 ...201728350512
molecular mechanisms of chronic wasting disease prion propagation.prion disease epidemics, which have been unpredictable recurrences, are of significant concern for animal and human health. examples include kuru, once the leading cause of death among the fore people in papua new guinea and caused by mortuary feasting; bovine spongiform encephalopathy (bse) and its subsequent transmission to humans in the form of variant creutzfeldt-jakob disease (vcjd), and repeated examples of large-scale prion disease epidemics in animals caused by contaminated vaccines. the ...201728193766
de novo generation of a unique cervid prion strain using protein misfolding cyclic amplification.substantial evidence supports the hypothesis that prions are misfolded, infectious, insoluble, and protease-resistant proteins (prp(res)) devoid of instructional nucleic acid that cause transmissible spongiform encephalopathies (tses). protein misfolding cyclic amplification (pmca) has provided additional evidence that prpres acts as a template that can convert the normal cellular prion protein (prp(c)) present in uninfected normal brain homogenate (nbh) into the infectious misfolded prp(res) is ...201728144628
the structure of mammalian prions and their aggregates.prion diseases, such as creutzfeldt-jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (i.e., deer, elk, moose, and reindeer), and sheep scrapie, are caused by the misfolding of the cellular prion protein (prp(c)) into a disease-causing conformer (prp(sc)). prp(c) is a normal, gpi-anchored protein that is expressed on the surface of neurons and other cell types. the structure of prp(c) is well understood, based on studies of recombinant prp, w ...201728109330
interferon-γ release assays for the diagnosis of mycobacterium tuberculosis infection in children: a literature review.the role of interferon-gamma release assays (igras) for immunologic diagnosis of tuberculosis in children is under debate. we carried out a narrative review on the studies on igras in paediatric populations. a literature search was conducted using multiple keywords and standardized terminology in medline, embase and cochrane databases, up to january 27th, 2011. study quality was assessed using the moose checklist and results of relevant studies were summarized. sixty-seven paediatric studies (st ...201722697065
morphological and molecular characterization of four sarcocystis spp., including sarcocystis linearis n. sp., from roe deer (capreolus capreolus) in italy.fresh (frozen/thawed) muscle samples from four 2-12-year-old roe deer (capreolus capreolus) from the sondrio province in north-eastern italy were examined under a dissecting microscope, and about 180 sarcocysts were isolated and identified to morphological type in wet mounts by light microscopy (lm). seventy-seven of these sarcocysts were subsequently examined by molecular methods, comprising polymerase chain reaction (pcr) amplification and sequencing of the partial cytochrome c oxidase subunit ...201728255918
detection and molecular characterization of the mosquito-borne filarial nematode setaria tundra in danish roe deer (capreolus capreolus).setaria tundra is a mosquito-borne filarial nematode of cervids in europe. it has recently been associated with an emerging epidemic disease causing severe morbidity and mortality in reindeer and moose in finland. here, we present the first report of s. tundra in six roe deer (capreolus capreolus) collected between october 2010 and march 2014 in denmark. the deer originated from various localities across the country: the eastern part of the jutland peninsular and four locations on the island zea ...201728229043
gross measurements of the digestive tract and visceral organs of addax antelope (addax nasomaculatus) following a concentrate or forage feeding regime.differences in macroscopic measurements of the gastrointestinal tract have been hypothesized to correlate with the browser-grazer continuum in the natural diet of ruminants. however, to what extent these characteristics represent species-specific traits, or respond to the actually ingested diet, remains to be investigated. twelve surplus addax antelope (addax nasomaculatus) were divided into two groups and fed, for 3 months, either their usual diet, consisting of a concentrate feed with a limite ...201728295511
serological testing of schmallenberg virus in swedish wild cervids from 2012 to 2016.schmallenberg virus (sbv) first emerged in europe in 2011, and in sweden in late 2012. the virus was still circulating in parts of europe in 2015. in recent testing, the virus has not been detected in swedish domestic animals, indicating that it is no longer circulating in sweden. it is not known if the virus has circulated and is still circulating in swedish wild cervid populations and whether wildlife can act as virus reservoirs. the aim of this study was to investigate whether sbv has circula ...201728376790
moose-tree interactions: rebrowsing is common across tree species.plant strategies to resist herbivory include tolerance and avoidance. tolerance strategies, such as rapid regrowth which increases the palatability of new shoots, can lead to positive feedback loops between plants and herbivores. an example of such a positive feedback occurs when moose (alces alces) browse trees in boreal forests. we described the degree of change in tree morphology that accumulated over time in response to repeated browsing by moose, using an index of accumulated browsing. we e ...201728376769
the influence of sulfur and hair growth on stable isotope diet estimates for grizzly bears.stable isotope ratios of grizzly bear (ursus arctos) guard hair collected from bears on the lower stikine river, british columbia (bc) were analyzed to: 1) test whether measuring δ34s values improved the precision of the salmon (oncorhynchus spp.) diet fraction estimate relative to δ15n as is conventionally done, 2) investigate whether measuring δ34s values improves the separation of diet contributions of moose (alces alces), marmot (marmota caligata), and mountain goat (oreamnos americanus) and ...201728248995
group or ungroup - moose behavioural response to recolonization of wolves.predation risk is a primary motivator for prey to congregate in larger groups. a large group can be beneficial to detect predators, share predation risk among individuals and cause confusion for an attacking predator. however, forming large groups also has disadvantages like higher detection and attack rates of predators or interspecific competition. with the current recolonization of wolves (canis lupus) in scandinavia, we studied whether moose (alces alces) respond by changing grouping behavio ...201728239401
effects of interspecific interaction-linked habitat factors on moose resource selection and environmental stress.resource selection of herbivores is a complex ecological process that operates in relation to biological or non-biological factors, which may affect the feeding and movement, and subsequently their spatial distribution and environmental stress. here, we estimated moose (alces alces cameloides) resource selection for habitat variables and the effect of interspecific interactions related to roe deer (capreolus pygargus bedfordi) on its population distribution and environmental stress in the khinga ...201728128311
habitat-performance relationships of a large mammal on a predator-free island dominated by humans.the demographic consequences of changes in habitat use driven by human modification of landscape, and/or changes in climate, are important for any species. we investigated habitat-performance relationships in a declining island population of a large mammal, the moose (alces alces), in an environment that is predator-free but dominated by humans. we used a combination of demographic data, knowledge of habitat selection, and multiannual movement data of female moose (n = 17) to understand how spac ...201728070294
ungulate predation and ecological roles of wolves and coyotes in eastern north america.understanding the ecological roles of species that influence ecosystem processes is a central goal of ecology and conservation biology. eastern coyotes (canis latrans) have ascended to the role of apex predator across much of eastern north america since the extirpation of wolves (canis spp.) and there has been considerable confusion regarding their ability to prey on ungulates and their ecological niche relative to wolves. eastern wolves (c. lycaon) are thought to have been the historical top pr ...201728064464
sarcocystis entzerothi n. sp. from the european roe deer (capreolus capreolus).in the present study, we describe sarcocystis entzerothi n. sp. from the european roe deer (capreolus capreolus) based on the microscopical and dna analysis. by light microscopy (lm), cysts of s. entzerothi were spindle-shaped with pointed tips, 950-1900 × 70-150 μm in size and had 5-6 μm long finger-like cyst wall protrusions. cyst wall of s. entzerothi by transmission electron microscopy (tem) was type 10a-like; villar protrusions were up to 1.2 μm wide, densely packed, lying about 0.1 μm betw ...201727752769
relationship between cd and zn concentration in the kidneys, liver, and muscles of moose (alces alces) from north-eastern poland.the aim of the study was to evaluate the cadmium and zinc content in the kidneys and liver of moose from north-eastern poland. animals were divided with respect to their age. the mean concentration of cadmium in the kidneys of moose studied was 11.31 mg kg(-1), while in the liver it amounted to 2.68 mg kg(-1). age had a significant effect on the content of cadmium in both organs. in the muscles of most animals studied, the cadmium concentrations were below the detection limit. elevated concentra ...201727743325
modelling moose-forest interactions under different predation scenarios at isle royale national park, usa.loss of top predators may contribute to high ungulate population densities and chronic over-browsing of forest ecosystems. however, spatial and temporal variability in the strength of interactions between predators and ungulates occurs over scales that are much shorter than the scales over which forest communities change, making it difficult to characterize trophic cascades in forest ecosystems. we applied the landis-ii forest succession model and a recently developed ungulate browsing extension ...201728263421
secular trends in the incidence of dementia in high-income countries: a protocol of a systematic review and a planned meta-analysis.a global dementia epidemic is projected for the year 2050 with an ever-rising number of individuals living with the syndrome worldwide. however, increasingly, studies are emerging from high-income countries (hic) that show a positive trend towards a possible decrease in dementia occurrence. therefore, we aim to systematically summarise evidence regarding secular trends in the incidence of dementia in hic.201728389488
laparoendoscopic single-site surgery versus conventional laparoscopy for hysterectomy: a systematic review and meta-analysis.to assess the safety and effectiveness of less compared to conventional hysterectomy.201728357561
the prevalence extent of complementary and alternative medicine (cam) use among saudis.introduction: there is worldwide interest in the use of cam. studying cam in saudi population is important as it will reflect the influence of psychosocial, cultural and religious factors on health beliefs and behaviors. the objective of this study was to present an updated review on the use of cam practices in saudi arabia including commonly used types, common conditions for which it has been used and who uses cam. methods: this review used data from national surveys conducted in saudi arabia a ...201728344484
angiosome-directed revascularization in patients with critical limb ischemia.direct revascularization (dr), according to the angiosome concept, provides direct blood flow to the site of tissue loss in patients with critical limb ischemia (cli). dr may lead to improved outcomes; however, evidence for this is controversial. this systematic review and meta-analysis investigated the outcomes of surgical and endovascular dr compared with indirect revascularization (ir) in patients with cli.201728342514
[current dental implant design and its clinical importance].the development of clinical implant dentistry was intensively affected by dental implant design improvement and innovation, which brought about new concept, even milestone-like changes of clinical protocol. the current improvements of dental implant design and their clinical importance could be highlighted as followings: 1) the implant apical design influences the implant preliminary stability in immediate implant. the apical 3-5 mm design of implant makes implant stable in immediate implant, be ...201728326723
the value of lncrna hulc as a prognostic factor for survival of cancer outcome: a meta-analysis.growing evidence from recent studies has shown that lncrna hulc plays a role in the development of multiple carcinomas. this meta-analysis aimed to analyze available data to identify the prognostic value of hulc in multiple tumors.201728315877
seven years of workplace drug testing in italy: a systematic review and meta-analysis.in italy, workplace drug testing (wdt) is compulsory by law for specific categories of workers since 2008, offering the opportunity to compare studies conducted within a single regulatory framework.201728304140
overweight or obesity in children aged 0 to 6 and the risk of adult metabolic-syndrome: a systematic review and meta-analysis.to identify an association between overweight or obesity in early childhood and metabolic syndrome in adults.201728295797
risk factors for the development of autism spectrum disorder in children with tuberous sclerosis complex: protocol for a systematic review.tuberous sclerosis complex (tsc) is an autosomal dominant condition, caused by mutations in either the tsc1 or tsc2 gene. it has widespread systemic manifestations and is associated with significant neurological morbidity. in addition to seizures and cerebral pathology including cortical tubers, subependymal nodules, subependymal giant cell astrocytoma and abnormal white matter, there are recognised neuropsychiatric difficulties including intellectual disability, autism spectrum disorder (asd) a ...201728270230
vestibular (dys)function in children with sensorineural hearing loss: a systematic review.the objective of this study is to provide an overview of the prevalence of vestibular dysfunction in children with snhl classified according to the applied test and its corresponding sensitivity and specificity.201728264605
the healthy weights initiative: the first 1,000 participants.according to statistics canada, the number of adults who are overweight or obese rises every year in canada. as such, it is obvious that various public policies are not working. after extensive community consultation, the healthy weights initiative (hwi) started in moose jaw and expanded to regina, saskatchewan, canada.201728260865
androgen receptor gene cag repeat polymorphism and ovarian cancer risk: a meta-analysis.ovarian cancer is one of the common gynecological malignancies worldwide. it is usually diagnosed at a later stage, thus missing the best opportunity for treatment. despite the advancement of ovarian cancer treatment, the prognosis is still poor. androgen receptor (ar) may play a role in ovarian carcinogenesis. previous studies regarding the association between ar cag repeat length and ovarian cancer risk reported inconsistent results. therefore, we conducted a meta-analysis to evaluate the asso ...201728250337
aneurysm rebleeding after placement of external ventricular drainage: a systematic review and meta-analysis.the association between external ventricular drainage (evd) and aneurysm rerupture is still a controversial issue. we performed a systematic review and meta-analysis of published series reporting data of evd placement in aneurysmal subarachnoid hemorrhage (sah) with the aim to evaluate the relationship between ventricular drainage and aneurysm rebleeding.201728243810
the interrelation between hypothyroidism and glaucoma: a critical review and meta-analyses.data on the association between hypothyroidism and glaucoma are conflicting. we sought to shed light on this by conducting a critical review and meta-analyses. the meta-analyses were conducted in adherence with the widely accepted moose guidelines. using the medical subject heading (mesh) terms: hypothyroidism, myxoedema and glaucoma or intraocular pressure, case-control studies, cohort studies and cross-sectional studies were identified (pubmed) and reviewed. using meta-analysis, the relative r ...201728211200
systematic review and meta-analysis of the efficacy of epidermal grafting for wound healing.autologous skin grafting is an important method for wound coverage; however, it is an invasive procedure and can cause donor site morbidity. epidermal grafting (eg) enables epidermal transfer to wounds with minimal donor site morbidity. however, data to date have been heterogeneous. this study aims to synthesise the current evidence on eg for wound healing to establish the efficacy of this surgical technique. a comprehensive search in the medline, embase and central databases was conducted. the ...201728198101
efficacy of the intravitreal sustained-release dexamethasone implant for diabetic macular edema refractory to anti-vascular endothelial growth factor therapy: meta-analysis and clinical implications.to assess the effect on best-corrected visual acuity (bcva) and efficacy of the intravitreal sustained-release 0.7 mg dexamethasone implant (ozurdex; allergan, irvine, ca) in patients with recalcitrant diabetic macular edema (dme).201728195619
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