Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| respiratory evaluation through volumetric capnography among grade iii obese and eutrophic individuals: a comparative study. | excess trunk body fat in obese individuals influences respiratory physiological function. the aims of this study were to compare volumetric capnography findings (vcap) between severely obese patients and normal-weight subjects and to assess whether there is any association between neck circumference (nc), waist-hip ratio (whr) and vcap among grade iii obese individuals. | 2018 | 29340500 |
| omalizumab in patients with severe uncontrolled asthma: well-defined eligibility criteria to promote asthma control. | 2018 | 29340498 | |
| mortality from idiopathic pulmonary fibrosis: a temporal trend analysis in brazil, 1979-2014. | to analyze mortality from idiopathic pulmonary fibrosis (ipf) in brazil over the period 1979-2014. | 2018 | 29340493 |
| survival in a cohort of patients with lung cancer: the role of age and gender in prognosis. | to determine the demographic and clinical characteristics of patients with non-small cell lung cancer (nsclc), as well as their disease course, by age group and gender. | 2018 | 29340491 |
| understanding diagnostic tests. part 2. | 2018 | 29340487 | |
| evolution in the management of non-small cell lung cancer in brazil. | 2018 | 29340484 | |
| idiopathic pulmonary fibrosis in brazil: challenges for epidemiological characterization and management. | 2018 | 29340483 | |
| clear cell odontogenic carcinoma of the mandible: a treatment strategy. | clear cell odontogenic carcinoma (ccoc) is a rare odontogenic tumor of the jaws, histologically characterized by the presence of agglomerates of cells with eosinophilic cytoplasm. the patient, a 62-year-old caucasian woman, presented an intraosseous lesion in the mandibular symphysis. a clinical examination revealed a discrete volumetric increase with a hard consistency, palpable to extraoral and intraoral examinations. imaging studies revealed an extensive radiolucent area, without defined limi ... | 2018 | 29340482 |
| bone repair access of boneceramic™ in 5-mm defects: study on rat calvaria. | the aim of this study was to evaluate the osteoconductive potential of boneceramic™ on bone healing in rat calvaria 5-mm defects. | 2018 | 29340480 |
| enzymes immobilized in langmuir-blodgett films: why determining the surface properties in langmuir monolayer is important? | in this review we discuss about the immobilization of enzymes in langmuir-blodgett films in order to determine the catalytic properties of these biomacromolecules when adsorbed on solid supports. usually, the conformation of enzymes depends on the environmental conditions imposed to them, including the chemical composition of the matrix, and the morphology and thickness of the film. in this review, we show an outline of manuscripts that report the immobilization of enzymes as lb films since the ... | 2018 | 29340479 |
| the long and successful journey of electrochemically active amino acids. from fundamental adsorption studies to potential surface engineering tools. | proteins have been the subject of electrochemical studies. it is possible to apply electrochemical techniques to obtain information about their structure due to the presence of five electroactive amino acids that can be oriented to the outside of the peptidic chain. these amino acids are l-tryptophan (l-trp), l-tyrosine (l-tyr), l-histidine (l-his), l-methionine (l-met) and l-cysteine (l-cys); their electrochemical behavior being subject of extensive research, but it is still controversial. no s ... | 2018 | 29340478 |
| prevalence of and risk factors associated with the presence of staphylococcus aureus in the chronic wounds of patients treated in primary health care settings in brazil. | wounds can be colonized by methicillin-resistant staphylococcus aureus (mrsa). | 2018 | 29340463 |
| rhodnius stali: new vector infected by trypanosoma rangeli (kinetoplastida, trypanosomatidae). | rhodnius stali infection by trypanosoma rangeli is reported in this study for the first time. | 2018 | 29340462 |
| synanthropic triatomines as potential vectors of trypanosoma cruzi in central brazil. | chagas disease surveillance requires current knowledge on synanthropic triatomines. we analyzed the occurrence and trypanosoma cruzi infection rates of triatomine bugs in central brazil, during 2012-2014. | 2018 | 29340461 |
| first serologic evidence of human hantavirus infection in alagoas state in northeastern brazil. | hantavirus cardiopulmonary syndrome (hcps) is rare in northeastern brazil. | 2018 | 29340460 |
| central venous catheter-related infections in patients receiving short-term hemodialysis therapy: incidence, associated factors, and microbiological aspects. | bloodstream infections are the second most common cause of death among patients on hemodialysis. this study aimed to evaluate the incidence of and risk factors associated with central venous catheter-related infections in patients undergoing hemodialysis, and to identify and characterize the type and antimicrobial susceptibility profiles of the primary microorganisms isolated during one year of follow-up. | 2018 | 29340455 |
| rose bengal catalysed photo-induced selenylation of indoles, imidazoles and arenes: a metal free approach. | in this report, the highly efficient rose bengal-catalysed c(sp2)-h selenylation of indoles, imidazoles and arenes was achieved using a half molar equiv. of diorganoyl diselenides. this metal-free, photo-induced protocol resulted in selenylated products in good to excellent yields. the reaction features are high yields, an atom-economic, gram-scalable and metal-free approach, and applicability to different biologically relevant (hetero)arenes. | 2018 | 29340417 |
| a new small-bodied ornithopod (dinosauria, ornithischia) from a deep, high-energy early cretaceous river of the australian-antarctic rift system. | a new small-bodied ornithopod dinosaur, diluvicursor pickeringi, gen. et sp. nov., is named from the lower albian of the eumeralla formation in southeastern australia and helps shed new light on the anatomy and diversity of gondwanan ornithopods. comprising an almost complete tail and partial lower right hindlimb, the holotype (nmv p221080) was deposited as a carcass or body-part in a log-filled scour near the base of a deep, high-energy river that incised a faunally rich, substantially forested ... | 2018 | 29340228 |
| transition-metal-free regiospecific aroylation of nitroarenes using ethyl arylacetates at room temperature. | a novel regiospecific c(sp3)-c(sp2) coupling between ethyl arylacetates and nitroarenes has been developed to deliver biaryl ketones in excellent yields. the protocol is metal-free, mild, and compatible with a number of functional groups on both of the reacting partners. | 2018 | 29345475 |
| the first south american case of pre-implantation genetic diagnosis to select compatible embryo for cord blood transplantation as treatment for sickle cell anemia. | sickle cell anemia is an inherited systemic hemoglobinopathy that affects hemoglobin production in red blood cells, leading to early morbidity and mortality. it is caused by a homozygous nucleotide substitution (c.20a>t) in the β-globin gene (hbb) that changes a glutamic acid to a valine in the protein. we present a case report of a fertile couple, both carriers of the sickle cell anemia mutation, with one affected daughter. six cycles of assisted reproductive techniques were performed, resultin ... | 2018 | 29345446 |
| the impact of high progesterone levels on the day of hcg administration in assisted human reproduction treatments. | progesterone is a steroid hormone that acts on the endometrium. it is known for producing physical and mood-related side effects. few studies have looked into how progesterone levels affect embryo development and quality. this study aimed to find a cutoff level for serum progesterone on the day of hcg administration from which embryo quality is impaired. | 2018 | 29345445 |
| glycine improves the remodeling process of tenocytes in vitro. | tendinitis changes the biochemical and morphological properties of the tendon, promoting an increase of activity of metalloproteinases and disorganization of collagen bundles. tenocytes the primary cells in tendon, are scattered throughout the collagenic fibres, and are responsible of tendon remodeling and tissue repair in pathological condition. in vivo, glycine, component of the typical gly-x-y collagen tripeptide, showed beneficial effects in biochemical and biomechanical properties of achill ... | 2018 | 29345399 |
| dentin bond strength and nanoleakage of the adhesive interface after intracoronal bleaching. | this study evaluated dentin bond strength (bs) and nanoleakage of non- and pre-etched dentin immediately (t0 ,), 7 days (t7 ), and 14 days (t14 ) after bleaching. bovine incisors (150) were selected and half of them submitted to intrapulpal dentin etching (e). non- and pre-etched dentin were subjected to the following (n = 15): no bleaching/control (c); 35% carbamide peroxide (cp); 35% hydrogen peroxide (35% hp); 25% hydrogen peroxide (25% hp); and sodium perborate (sp). bleaching agents were ap ... | 2018 | 29345388 |
| truncation of neurokinin-1 receptor-negative regulation of substance p signaling. | substance p (sp) is a tachykinin peptide, which triggers intracellular signaling in the nervous and immune systems, as well as, other local and systemic events. the interaction between sp and its receptor, neurokinin-1 receptor (nk1r), results in major downstream cellular actions, which include changes in calcium fluxes, erk, and p21-activated kinase phosphorylation and nfκb activation. two naturally occurring variants of the nk1r, the full-length, 407 aa receptor (nk1r-f) and the truncated, 311 ... | 2018 | 29345372 |
| retrospective study on midfacial advancement in syndromic craniosynostosis: case series. | the aim of this study was to evaluate elastic distraction surgical procedures performed on patients with syndromic craniosynostosis using cephalometric analyses. | 2018 | 29345318 |
| synthesis of α-formylated n-heterocycles and their 1,1-diacetates from inactivated cyclic amines involving an oxidative ring contraction. | a novel synthesis of pyrrolidine-2-carbaldehydes or tetrahydropyridine-2-carbaldehydes from the cascade reactions of n-arylpiperidines or n-arylazepanes is presented. mechanistically, the formation of the title compounds involves an unprecedented oxidative ring contraction of inactivated cyclic amines via cu(oac)2/ki/o2-promoted oxidative cleavage and reformation of the c-n bond. interestingly, when phi(oac)2 was used in place of ki, 1,1-diacetates of the corresponding aldehydes were directly ob ... | 2018 | 29345128 |
| assessing and addressing cognitive impairment in bipolar disorder: the international society for bipolar disorders targeting cognition task force recommendations for clinicians. | cognition is a new treatment target to aid functional recovery and enhance quality of life for patients with bipolar disorder. the international society for bipolar disorders (isbd) targeting cognition task force aimed to develop consensus-based clinical recommendations on whether, when and how to assess and address cognitive impairment. | 2018 | 29345040 |
| short-term and long-term effects of osteoporosis on incisor teeth and femoral bones evaluated by raman spectroscopy and energy dispersive x-ray analysis in ovariectomized rats. | there are few published data on the relationship between loss of bone mass due to osteoporosis and poor tooth quality. this study analyzed the effects of osteoporosis on incisor teeth and femoral bones using optical techniques in rats. twenty female wistar rats aged 6 months (n = 20) were randomized into two groups: control group, non-ovariectomized rats (n = 10); ovariectomy group, ovariectomized rats to induce osteoporosis (n = 10). each group was subdivided randomly into two groups containing ... | 2018 | 29344812 |
| temperature dependence of raman-active in-plane e2g phonons in layered graphene and h-bn flakes. | thermal properties of sp2 systems such as graphene and hexagonal boron nitride (h-bn) have attracted significant attention because of both systems being excellent thermal conductors. this research reports micro-raman measurements on the in-plane e2g optical phonon peaks (~ 1580 cm-1 in graphene layers and ~ 1362 cm-1 in h-bn layers) as a function of temperature from - 194 to 200 °c. the h-bn flakes show higher sensitivity to temperature-dependent frequency shifts and broadenings than graphene fl ... | 2018 | 29344758 |
| structural associations between organelle membranes in nectary parenchyma cells. | the close association between membranes and organelles, and the intense chloroplast remodeling in parenchyma cells of extrafloral nectaries occurred only at the secretion time and suggest a relationship with the nectar secretion. associations between membranes and organelles have been well documented in different tissues and cells of plants, but poorly explored in secretory cells. here, we described the close physical juxtaposition between membranes and organelles, mainly with chloroplasts, in p ... | 2018 | 29344723 |
| microbial characterization of methanogenic and iron-reducing consortium in reactors with polychlorinated biphenyls. | recent papers have confirmed current environmental pollution and the continuous release of polychlorinated biphenyls (pcbs) despite the prohibition of its manufacture worldwide. as the dehalogenating microorganisms are able to remove halogens from various analogous compounds, the characterization of pcb metabolisms can improve the degradation of similar compounds. thus, this study extensively evaluated the microbial community developed in methanogenic and iron-reducing reactors. the horizontal-f ... | 2018 | 29344709 |
| vision status in older adults: the brazilian amazon region eye survey. | older adults living in remote areas with limited access to health services are at higher risk to develop visual impairment and blindness. we conducted a population-based survey to determine the vision status in subjects 45 years of age and older from urban and rural areas of parintins city, brazilian amazon region. participants underwent ophthalmic examination, including uncorrected (ucva), presenting (pva) and best-corrected visual acuity (bcva). vision status was described as lines of visual a ... | 2018 | 29343840 |
| musical auditory stimulus acutely influences heart rate dynamic responses to medication in subjects with well-controlled hypertension. | music can improve the efficiency of medical treatment when correctly associated with drug action, reducing risk factors involving deteriorating cardiac function. we evaluated the effect of musical auditory stimulus associated with anti-hypertensive medication on heart rate (hr) autonomic control in hypertensive subjects. we evaluated 37 well-controlled hypertensive patients designated for anti-hypertensive medication. heart rate variability (hrv) was calculated from the hr monitor recordings of ... | 2018 | 29343839 |
| multiple losses of photosynthesis and convergent reductive genome evolution in the colourless green algae prototheca. | autotrophic eukaryotes have evolved by the endosymbiotic uptake of photosynthetic organisms. interestingly, many algae and plants have secondarily lost the photosynthetic activity despite its great advantages. prototheca and helicosporidium are non-photosynthetic green algae possessing colourless plastids. the plastid genomes of prototheca wickerhamii and helicosporidium sp. are highly reduced owing to the elimination of genes related to photosynthesis. to gain further insight into the reductive ... | 2018 | 29343788 |
| species distribution modelling: contrasting presence-only models with plot abundance data. | species distribution models (sdms) are widely used in ecology and conservation. presence-only sdms such as maxent frequently use natural history collections (nhcs) as occurrence data, given their huge numbers and accessibility. nhcs are often spatially biased which may generate inaccuracies in sdms. here, we test how the distribution of nhcs and maxent predictions relates to a spatial abundance model, based on a large plot dataset for amazonian tree species, using inverse distance weighting (idw ... | 2018 | 29343741 |
| the anti-inflammatory action of maropitant in a mouse model of acute pancreatitis. | the neurokinin 1 receptor (nk1r) plays an important role in the pathogenesis of acute pancreatitis (ap). maropitant is an nk1r antagonist that is widely used as an antiemetic in dogs and cats. in the present study, we investigated the anti-inflammatory action of maropitant in a mouse model of ap. ap was induced in balb/c mice by intraperitoneal administration of cerulein, and maropitant was administered subcutaneously at a dose of 8 mg/kg. we assessed the mrna expression levels of nk1r and subst ... | 2018 | 29343664 |
| biochemical characterization of halophilic, alkalithermophilic amylopullulanase puld7 and truncated amylopullulanases puld7δn and puld7δc. | a pullulanase, puld7, was identified in the genome of the halophilic, alkalithermophilic isolate alkalilimnicola sp. nm-dcm-1. puld7 is 701 amino acids large with a carbohydrate binding module (cbm) 48 at the n-terminal. the full length puld7 and n- and c-terminal truncated versions were cloned, heterologously expressed and functionally characterized. puld7 displayed maximal activity at 55 °c, ph 9.5 and 2 m nacl. puld7 had good thermal stability, with a half-life of 693 min at 50 °c. puld7 is a ... | 2018 | 29343451 |
| p-mapa immunotherapy potentiates the effect of cisplatin on serous ovarian carcinoma through targeting tlr4 signaling. | toll-like receptors (tlrs) are transmembrane proteins expressed on the surface of ovarian cancer (oc) and immune cells. identifying the specific roles of the tlr-mediated signaling pathways in oc cells is important to guide new treatments. because immunotherapies have emerged as the adjuvant treatment for patients with oc, we investigated the effect of a promising immunotherapeutic strategy based on protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride (p-mapa) combined wi ... | 2018 | 29343281 |
| influence of apocynin on cardiac remodeling in rats with streptozotocin-induced diabetes mellitus. | increased reactive oxygen species (ros) generation in diabetes mellitus (dm) is an important mechanism leading to diabetic cardiomyopathy. apocynin, a drug isolated from the herb picrorhiza kurroa, is considered an antioxidant agent by inhibiting nadph oxidase activity and improving ros scavenging. this study analyzed the influence of apocynin on cardiac remodeling in diabetic rats. | 2018 | 29343259 |
| ceratocystis cacaofunesta genome analysis reveals a large expansion of extracellular phosphatidylinositol-specific phospholipase-c genes (pi-plc). | the ceratocystis genus harbors a large number of phytopathogenic fungi that cause xylem parenchyma degradation and vascular destruction on a broad range of economically important plants. ceratocystis cacaofunesta is a necrotrophic fungus responsible for lethal wilt disease in cacao. the aim of this work is to analyze the genome of c. cacaofunesta through a comparative approach with genomes of other sordariomycetes in order to better understand the molecular basis of pathogenicity in the ceratocy ... | 2018 | 29343217 |
| human semen or seminal plasma do not enhance hiv-1bal ex vivo infection of human colonic explants. | to determine whether human whole semen (ws) and seminal plasma (sp) either previously frozen or freshly acquired altered ex vivo infectibility of human colonic explants or was associated with histology or toxicity changes which may influence mucosal hiv-1 transmission in vivo. | 2018 | 29343073 |
| biogenic weathering: solubilization of iron from minerals by epilithic freshwater algae and cyanobacteria. | a sandstone outcrop exposed to freshwater seepage supports a diverse assemblage of photosynthetic microbes. dominant taxa are two cyanophytes (oscillatoria sp., rivularia sp.) and a unicellular green alga (palmellococcus sp.). less abundant taxa include a filamentous green alga, microspora, and the desmid cosmarium. biologic activity is evidenced by measured levels of chlorophyll and lipids. bioassay methods confirm the ability of these microbes to dissolve and metabolize fe from ferruginous min ... | 2018 | 29342973 |
| estrogen and thyroid hormone receptor activation by medicinal plants from bahia, brazil. | background: a number of medicinal plants are traditionally used for metabolic disorders in bahia state, brazil. the aim of this study was to evaluate the estrogen receptor (er) and thyroid receptor (tr) activation of crude extracts prepared from 20 plants. methods: species were extracted and assayed for receptor activation through both er and tr gene-reporter assays, using 17β-estradiol and triiodothyronine (t3), respectively, as the positive controls. results: cajanus cajan (fabaceae), abarema ... | 2018 | 29342924 |
| polymer-ceramic composite scaffolds: the effect of hydroxyapatite and β-tri-calcium phosphate. | the design of bioactive scaffolds with improved mechanical and biological properties is an important topic of research. this paper investigates the use of polymer-ceramic composite scaffolds for bone tissue engineering. different ceramic materials (hydroxyapatite (ha) and β-tri-calcium phosphate (tcp)) were mixed with poly-ε-caprolactone (pcl). scaffolds with different material compositions were produced using an extrusion-based additive manufacturing system. the produced scaffolds were physical ... | 2018 | 29342890 |
| improving perinatology residents' skills in breaking bad news: a randomized intervention study. | breaking bad news (bbn) is particularly difficult in perinatology. previous research has shown that bbn skills can be learned and improved when taught and practiced. this project evaluated whether a structured training session would enhance perinatology residents' skills in bbn. | 2018 | 29342495 |
| how does the patient react after reading the informed consent form of a gynecological surgery? a qualitative study. | to analyze the reaction of women after reading the informed consent form (icf) before undergoing elective gynecological/urogynecological surgeries. | 2018 | 29342494 |
| validation of a simplified implant-retained cantilever fixed prosthesis. | to evaluate the stress and strain generated in a fixed four-element prosthesis under the application of axial and nonaxial loads using a simplified implant-supported fixed prosthesis model. | 2018 | 29341975 |
| activation of estrogen receptor beta (erβ) regulates the expression of n-cadherin, e-cadherin and β-catenin in androgen-independent prostate cancer cells. | the aim of the present study was to investigate the impact of the activation of estrogen receptors on expression and localization of n-cadherin, e-cadherin and non-phosphorylated β-catenin in androgen-independent prostate cancer cells (pc-3 and du-145) and in human post pubertal prostate epithelial cells (pnt1a). expression of n-cadherin was detected in pnt1a and pc-3 cells, but not in du-145 cells. e-cadherin was detected only in du-145 cells and β-catenin was detected in all cells studied. n-c ... | 2018 | 29341930 |
| exosome-mediated breast cancer chemoresistance via mir-155 transfer. | breast cancer remains the most prevalent cause of cancer mortality in woman worldwide due to the metastatic process and therapy resistance. resistance against cancer therapy is partially attributed to cancer stem cells (cscs). these cells arise from epithelial cells undergoing epithelial-to-mesenchymal transition (emt) and might be responsible for tumor recurrence. in this study, we reported the relevance of mir-155 upregulation in chemoresistant cells associated with emt. notably, we found mir- ... | 2018 | 29339789 |
| biochemical and genetic characterization of a novel metallo-β-lactamase from marine bacterium erythrobacter litoralis htcc 2594. | metallo-β-lactamases (mbls) are a group of enzymes that can inactivate most commonly used β-lactam-based antibiotics. among mbls, new delhi metallo-β-lactamase-1 (ndm-1) constitutes an urgent threat to public health as evidenced by its success in rapidly disseminating worldwide since its first discovery. here we report the biochemical and genetic characteristics of a novel mbl, elbla2, from the marine bacterium erythrobacter litoralis htcc 2594. this enzyme has a higher amino acid sequence simil ... | 2018 | 29339760 |
| performance and stability of an expanded granular sludge bed reactor modified with zeolite addition subjected to step increases of organic loading rate (olr) and to organic shock load (osl). | this paper shows the effect of organic shock loads (osls) on the anaerobic digestion (ad) of synthetic swine wastewater using an expanded granular sludge bed (egsb) reactor modified with zeolite. two reactors (r1 and r2), each with an effective volume of 3.04 l, were operated for 180 days at a controlled temperature of 30 °c and hydraulic retention time of 12 h. in the case of r2, 120 g of zeolite was added. the reactors were operated with an up-flow velocity of 6 m/h. the evolution of ph, total ... | 2018 | 29339602 |
| thymic stromal lymphopoietin drives the development of il-13+ th2 cells. | t helper 2 (th2) cells are pivotal in the development of allergy. allergen exposure primes il-4+ th2 cells in lymph node, but production of effector cytokines including il-5 and il-13 is thought to require additional signals from antigen and the environment. here we report that a substantial proportion of naive cd4+ t cells in spleen and lymph node express receptors for the epithelium-derived inflammatory cytokine thymic stromal lymphopoietin (tslp). culture of naive cd4+ t cells in anti-(a)cd3, ... | 2018 | 29339496 |
| a novel two-component system of streptococcus sanguinis affecting functions associated with viability in saliva and biofilm formation. | streptococcus sanguinis is a pioneer species of teeth and a common opportunistic pathogen of infective endocarditis. in this study, we identified a two-component system, sptrs ss , affecting s. sanguinis survival in saliva and biofilm formation. isogenic mutants of sptrss (sksptr) and sptsss (skspts) showed reduced cell counts in ex vivo assays of viability in saliva, compared to parent strain sk36 and complemented mutants. reduced counts of the mutants in saliva were associated with reduced gro ... | 2018 | 29339459 |
| new shuttle vectors for gene cloning and expression in multidrug-resistant acinetobacter species. | understanding bacterial pathogenesis requires adequate genetic tools to assess the role of individual virulence determinants by mutagenesis and complementation assays, as well as for homologous and heterologous expression of cloned genes. our knowledge of acinetobacter baumannii pathogenesis has so far been limited by the scarcity of genetic tools to manipulate multi drug resistant (mdr) epidemic strains which are responsible for most of infections. here, we report the construction of new multi- ... | 2018 | 29339383 |
| characterization of two extracellular β-glucosidases produced from the cellulolytic fungus aspergillus sp. ydj216 and their potential applications for the hydrolysis of flavone glycosides. | a cellulolytic fungus ydj216 was isolated from a compost and identified as an aspergillus sp. strain. two extracellular β-glucosidases, bgl1 and bgl2, were purified using ultrafiltration, ammonium sulfate fractionation, and high-q chromatography. molecular masses of bgl1 and bgl2 were estimated to be 97 and 45 kda, respectively, by sds-page. the two enzymes eluted as one peak at 87 kda by sephacryl s-200 chromatography, and located at similar positions in a zymogram after intact gel electrophore ... | 2018 | 29339289 |
| hyaluronic acid in pluronic f-127/f-108 hydrogels for postoperative pain in arthroplasties: influence on physico-chemical properties and structural requirements for sustained drug-release. | in this study, we reported the hyaluronic acid (ha) on supramolecular structure of pluronic f-127 (plf-127) and/or pluronic f-108 (plf-127) hydrogels, as well as their effects on release mechanisms, looking forward their application as lidocaine (ldc) drug-delivery systems in arthroplastic surgeries. we have studied the ha-micelle interaction using dynamic light scattering (dls), the micellization and sol-gel transition processes by differential scanning calorimetry (dsc) and rheology., of pl-ba ... | 2018 | 29339288 |
| hydroxyethyl cellulose hydrogel for wound dressing: fabrication, characterization and in vitro evaluation. | in this study, new hydrogel membranes were developed based on hydroxyethyl cellulose (hec) supplemented with tungsten oxide for further implementing in wound treatment. hec hydrogel membranes were fabricated and crosslinked using citric acid (ca). various tests were carried out including ftir, xrd, porosity measurements, swelling, mechanical properties, gel fraction, and thermal gravimetric analysis to evaluate the efficiency of the prepared membranes as wound dressing material. in addition, wou ... | 2018 | 29339283 |
| current status and perspectives of fungal entomopathogens used for microbial control of arthropod pests in brazil. | entomopathogenic fungi play a central role in brazil's biopesticide market. approximately 50% of registered microbial biopesticides comprise mycoinsecticides consisting of hypocrealean fungi, with most based on metarhizium anisopliae sensu stricto (s.str.) and beauveria bassiana (s.str.). these fungi are used to control spittlebugs in sugarcane fields and whiteflies in row crops, respectively, with annual applications surpassing three million hectares. research in brazil also emphasizes the pote ... | 2018 | 29339191 |
| aerobic and anaerobic cellulose utilization by paenibacillus sp. caa11 and enhancement of its cellulolytic ability by expressing a heterologous endoglucanase. | for cost-effective lignocellulosic biofuel/chemical production, consolidated bioprocessing (cbp)-enabling microorganisms utilizing cellulose as well as producing biofuel/chemical are required. a novel strain paenibacillus sp. caa11 isolated from sediment was found to be not only as a cellulose degrader under both aerobic and strict anaerobic conditions but also as a producer of cellulosic biofuel/chemicals. paenibacillus sp. caa11 secreted cellulolytic enzymes by its own secretion system and pro ... | 2018 | 29339118 |
| spirulina ameliorates methotrexate hepatotoxicity via antioxidant, immune stimulation, and proinflammatory cytokines and apoptotic proteins modulation. | methotrexate (mtx) is an efficient cytotoxic drug used against various carcinogenic, inflammatory and autoimmune diseases; however, the hepatotoxicity of mtx limits its use. therefore, the present study aimed to evaluate the potential hepatoprotective and immune-stimulant effect of spirulina platensis (sp) against mtx acute toxicity. | 2018 | 29339102 |
| disorder-to-order transitions in the molten globule-like golgi reassembly and stacking protein. | golgi reassembly and stacking proteins (grasps) are widely spread among eukaryotic cells (except plants) and are considered as key components in both the stacking of the golgi cisternae and its lateral connection. furthermore, grasps were also proved essential in the unconventional secretion pathway of several proteins, even though the mechanism remains obscure. it was previously observed that the grasp homologue in cryptococcus neoformans has a molten globule-like behavior in solution. | 2018 | 29339081 |
| knowledge on asthma, food allergies, and anaphylaxis: assessment of elementary school teachers, parents/caregivers of asthmatic children, and university students in uruguaiana, in the state of rio grande do sul, brazil. | allergic diseases have become an increasingly common reality in the last years, extending beyond the family context. | 2018 | 29338962 |
| ceratomyxa gracillima n. sp. (cnidaria: myxosporea) provides evidence of panmixia and ceratomyxid radiation in the amazon basin. | we describe a new freshwater myxosporean species ceratomyxa gracillima n. sp. from the gall bladder of the amazonian catfish brachyplatystoma rousseauxii; the first myxozoan recorded in this host. the new ceratomyxa was described on the basis of its host, myxospore morphometry, ssrdna and internal transcribed spacer region (its-1) sequences. infected fish were sampled from geographically distant localities: the tapajós river, pará state, the amazon river, amapá state and the solimões river, amaz ... | 2018 | 29338808 |
| development and validation of hptlc fingerprints of three species of alpinia with biomarker galangin. | alpinia galanga (l.) willd. commonly called as rasna, greater galangal or kulinjan is a medicinally important rhizome used in indian traditional system of medicine to cure a number of ailments. a. galanga is the main source of a galangin -a medicinally important flavanol which has a number of pharmacological properties viz. anti-mutagenic, and anti-inflammatory. due to the high demand for the rhizome of a. galanga traders are now substituting it with rhizomes of a. calcarata and a. officinarum. | 2018 | 29338724 |
| delivery of chemotherapeutics using spheres made of bioengineered spider silks derived from masp1 and masp2 proteins. | analysis of the properties and chemotherapeutics delivery potential of spheres made of bioengineered spider silks ms1 and ms2. | 2018 | 29338625 |
| protein nanoparticles are nontoxic, tuneable cell stressors. | nanoparticle-cell interactions can promote cell toxicity and stimulate particular behavioral patterns, but cell responses to protein nanomaterials have been poorly studied. | 2018 | 29338574 |
| catalytic dehydrogenative stannylation of c(sp)-h bonds involving cooperative sn-h bond activation of hydrostannanes. | the catalytic generation of a stannylium-ion-like tin electrophile by heterolytic cleavage of the sn-h bond in hydrostannanes at the ru-s bond of ohki-tatsumi complexes is reported. reacting these activated hydrostannanes with terminal acetylenes does not lead to hydrostannylation of the c-c triple bond but to dehydrogenative stannylation of the alkyne terminus. the scope of this rare direct c(sp)-h bond stannylation with hydrostannanes is broad, and a mechanism involving a β-tin-stabilized viny ... | 2018 | 29338212 |
| search for independent (β/α)4 subdomains in a (β/α)8 barrel β-glucosidase. | proteins that fold as (β/α)8 barrels are thought to have evolved from half-barrels that underwent duplication and fusion events. the evidence is particularly clear for small barrels, which have almost identical halves. additionally, computational calculations of the thermodynamic stability of these structures in the presence of denaturants have revealed that (β/α)8 barrels contain two subunits or domains corresponding to half-barrels. hence, within (β/α)8 barrels, half-barrels are self-contained ... | 2018 | 29338043 |
| the plant growth-promoting fungus (pgpf) alternaria sp. a13 markedly enhances salvia miltiorrhiza root growth and active ingredient accumulation under greenhouse and field conditions. | plant growth-promoting fungi (pgpf) have attracted considerable interest as bio-fertilisers due to their multiple beneficial effects on plant quantity and quality and their positive relationship with the ecological environment. advancements in the development of pgpf for crops and economic plant cultivation applications have been achieved, but such improvements for the use of pgpf with popular medicinal herbs, such as salvia miltiorrhiza, are rare. in this study, we collected s. miltiorrhiza spe ... | 2018 | 29337927 |
| effects of transcutaneous electrical nerve stimulation on pain intensity during application of carboxytherapy in patients with cellulite: a randomized placebo-controlled trial. | carboxytherapy may generate local pain that is considered the main limiting factor in clinical practice. transcutaneous electric nerve stimulation (tens) is widely used in the control of acute pain; however, the effect of tens on pain relief during carboxytherapy has not been studied to date. | 2018 | 29337405 |
| complete genome sequencing of the luminescent bacterium, vibrio qinghaiensis sp. q67 using pacbio technology. | vibrio qinghaiensis sp.-q67 (vqin-q67) is a freshwater luminescent bacterium that continuously emits blue-green light (485 nm). the bacterium has been widely used for detecting toxic contaminants. here, we report the complete genome sequence of vqin-q67, obtained using third-generation pacbio sequencing technology. continuous long reads were attained from three pacbio sequencing runs and reads >500 bp with a quality value of >0.75 were merged together into a single dataset. this resultant highly ... | 2018 | 29337313 |
| citrus bioflavonoid, hesperetin, as inhibitor of two thrombin-like snake venom serine proteases isolated from crotalus simus. | around 5.5 million people suffer from snakebites per year, with about 400,000 cases with some type of sequelae, such as amputation, and 20,000 to 125,000 cases with the fatal end. usually, the victim outcome depends on correct, agile and many times in situ intervention based on the proper identification of the snake venom type and its potential effects, among other factors. therefore, knowledge on the snake venom composition and a research on inhibitors of snake venom target components might ame ... | 2018 | 29337219 |
| bioactive potential and composition analysis of sulfated polysaccharide from acanthophora spicifera (vahl) borgeson. | marine seaweeds contain a valuable source of functional bioactive polysaccharide and it plays main role for effective anticancer activity. the structural feature of sps was studied through ft-ir and 1h nmr spectra analysis. the isolated sps from a. spicifera contain 63.3% of total sugar, 21.9% of total sulfate and 12.6% of total uranic acid was found. the active f2 fraction molecular weight of sp was found to be 420 kda. the sugar was composed of galactose (73.5%), xylose (9.2%), mannose (1.9%) ... | 2018 | 29337104 |
| obesity and hypertension in latin america: current perspectives. | in the countries of central america, south america and the caribbean, there has been a dramatic rise in obesity, the metabolic syndrome, hypertension and other cardiovascular risk factors in the last few decades. epidemiological evidence highlights a consistent correlation between obesity and hypertension, and the presence of obesity predisposes an individual to a greater risk of hypertension although the mechanisms remain unclear. obesity and hypertension are two key drivers of the cardio-renal ... | 2018 | 29361428 |
| bacterioplankton composition in tropical high-elevation lakes of the andean plateau. | high-elevation lakes in the tropics are subject to extreme environmental fluctuations and microbes may harbour a unique genomic repertoire, but their composition and diversity are largely unknown. here we compared the planktonic bacterial community composition (bcc) and diversity of three tropical lakes located in the high andean plateau (???4400 m above sea level) during the dry and wet season. diversity in these lakes was higher in the cool and wet season than in the warm and dry one. otus com ... | 2018 | 29346530 |
| the genus opisthacanthus peters, 1861 (scorpiones: hormuridae), a remarkable gondwanian group of scorpions. | new comments are proposed on the geographic distribution of genus opisthacanthus, and the gondwanian model is further supported. the diversity of the genus is extraordinary in madagascar, with the same number of species as in continental africa, but sub-saharan africa is home to six out of the nine groups currently recognized of opisthacanthus. given the affinities of the opisthacanthus groups and their current distribution, a center of origin in africa could be favored for these ancient scorpio ... | 2018 | 29337011 |
| ice pack induced perineal analgesia after spontaneous vaginal birth: randomized controlled trial. | ice-pack is widely used for alleviating postpartum perineal pain sustained after birth related perineal trauma. however, it lacks robust evidence on timing and frequency of applications, to ensure the effective and safe use of this therapy. | 2018 | 29337008 |
| groel ring separation and exchange in the chaperonin reaction. | the bacterial chaperonin groel and its cofactor, groes, form a nano-cage for a single molecule of substrate protein (sp) to fold in isolation. groel and groes undergo an atp-regulated interaction cycle to close and open the folding cage. groel consists of two heptameric rings stacked back to back. here, we show that groel undergoes transient ring separation, resulting in ring exchange between complexes. ring separation occurs upon atp-binding to the trans ring of the asymmetric groel:7adp:groes ... | 2018 | 29336887 |
| reliability and minimal detectable change of thoracoabdominal mobility measurements using photogrammetry. | the knowledge about measurement errors of the measuring tool is important before its use, as clinical decisions are going to be made based on its results. here we investigate intrarater and interrater reliability and the minimal detectable change (mdc) of thoracoabdominal mobility measurements using photogrammetry, considering novice and experienced raters. thoracoabdominal mobility of 17 healthy participants was assessed; photographs during apnea in maximal inspiration and expiration were used ... | 2018 | 29336712 |
| benzophenone-4 promotes the growth of a pseudomonas sp. and biogenic oxidation of mn(ii). | interactions between microbes and micropollutants (mps) play a crucial role in water purification or treatment. current studies have generally focused on the direct degradation or cometabolism of mps. considering the increasing interest in and importance of the roles of mps in microbial metabolism, we adopted an mn(ii)-oxidizing pseudomonas sp. qjx-1 using tyrosine (tyr) as the sole carbon and nitrogen source to investigate the effects of seven mps on its growth and function. six mps exhibited a ... | 2018 | 29336564 |
| sappinia sp. (amoebozoa: thecamoebida) and rosculus sp. (sar: cercozoa) isolated from king penguin guano collected in the subantarctic (south georgia, salisbury plain) and their coexistence in culture. | two amoeboid organisms of the genera sappinia dangeard, 1896 and rosculus hawes, 1963 were identified in a sample containing king penguin guano. this sample, collected in the subantarctic, enlarges the list of fecal habitats known for the presence of coprophilic amoebae. the two organisms were co-isolated and subcultured for over 6 months, continuous efforts being invested to separate each one from the mixed culture. in the mixed culture, rosculus cells were fast growing, tolerated changes in cu ... | 2018 | 29336503 |
| transcriptional regulation of hiv-1 host factor commd1 by the sp family. | copper metabolism murr1 domain containing 1 (commd1) has multiple functions in the regulation of protein stability at the plasma membrane and in the cytoplasm. however, the regulation of commd1 transcriptional has remained to be elucidated. in the present study, the 5'‑flanking region (‑1,192/+83 bp) of the human commd1 gene was cloned. it was observed that the commd1 promoter region contains gc‑rich region that has 7 putative sp1‑binding sites via in silico analysis. the proximal promoter regio ... | 2018 | 29336469 |
| semimetallic carbon honeycombs: new three-dimensional graphene allotropes with dirac cones. | classic two-dimensional (2d) graphene possesses outstanding properties due to dirac cone structures. when scaling up to three-dimensional (3d) structures, their high porosity and large surface-area-to-volume ratio made them have more promising engineering perspectives. however, the currently synthesized and density-functional-theory-predicted 3d graphene structures, termed as carbon honeycombs (chcs), are metallic. herein, we propose new families of stable semimetallic chc structures, which have ... | 2018 | 29336453 |
| manganese/cobalt-catalyzed oxidative c(sp3)-h/c(sp3)-h coupling: a route to α-tertiary β-arylethylamines. | reported herein is an oxidative coupling reaction of an α-c(sp3)-h bond of amine with a benzylic c(sp3)-h bond through mn or co catalysis to provide diverse collections of α-tertiary β-arylethylamines. this protocol features an easily installed and removable coordinating activation group, a wide scope of substrates, low-cost metal catalysts, easily available starting materials and synthetic simplicity. | 2018 | 29336440 |
| chromosome gene orientations inversion networks (goins) of plasmodium proteome. | the spatial distribution of genes in chromosomes seems not to be random. for instance, only 10% of genes are transcribed from bidirectional promoters in humans and many more are organised in larger clusters. this raises intriguing questions asked by different authors before. we would like to add a few more questions in this context, related to gene orientation inversions. does gene orientation (inversion) follow a random pattern? is it relevant to biological activity somehow? in this paper, we d ... | 2018 | 29336158 |
| mutation of phenylalanine-223 to leucine enhances transformation of benzo[a]pyrene by ring-hydroxylating dioxygenase of sphingobium sp. fb3 by increasing accessibility of the catalytic site. | burning of agricultural biomass generates polycyclic aromatic hydrocarbons (pahs) including the carcinogen benzo[a]pyrene, of which the catabolism is primarily initiated by a ring-hydroxylating dioxygenase (rhd). this study explores catalytic site accessibility and its role in preferential catabolism of some pahs over others. the genes flna1f, flna2f, flna3, and flna4, encoding the oxygenase α and β subunits, ferredoxin, and ferredoxin reductase, respectively, of the rhd enzyme complex (flna) we ... | 2018 | 29336152 |
| chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: potent butyrylcholinesterase inhibitors. | alzheimer's disease (ad) is the most common form of dementia worldwide with an increasing prevalence for the next years. the multifactorial nature of ad precludes the design of new drugs directed to a single target being probably one of the reasons for recent failures. therefore, dual binding site acetylcholinesterase (ache) inhibitors have been revealed as cognitive enhancers and β-amyloid modulators offering an alternative in ad therapy field. based on the dual ligands np61 and donepezil, the ... | 2018 | 29335209 |
| biofuel production and phycoremediation by chlorella sp. istla1 isolated from landfill site. | the present study aims to investigate the biofuel production ability and potential of heavy metal remediation of chlorella sp. istla1 isolated from a landfill site. the strain was cultured in bold's basal medium at different concentration of nahco3 and ph. response surface methodology was employed for the optimization of nutrient sources for higher lipid production. under the optimized conditions, the yield of lipid and biomass was 365.42 and 833.14 mg l-1 respectively. gc-ms analysis of lipid i ... | 2018 | 29335189 |
| rheological and calorimetric study of alkyltrimethylammonium bromide-sodium salicylate wormlike micelles in aqueous binary systems. | it is known that additives like glycerol and sucrose lead to the swelling of aqueous bilayer lα phases. the swelling of the lα phases can be explained by the increase of the refractive index of the mixed solvent, which lowers the van der waals attraction between the bilayers. afterwards, the undulation forces between the bilayers can push them apart. this hypothesis was previously extended to wormlike micelles (wlm) of cetyltrimethylammonium bromide (ctab) and sodium salicylate (nasal). these ty ... | 2018 | 29335186 |
| the efficacy of a multimodal physical activity intervention with supervised exercises, health coaching and an activity monitor on physical activity levels of patients with chronic, nonspecific low back pain (physical activity for back pain (payback) trial): study protocol for a randomised controlled trial. | physical activity plays an important role in the management of chronic low back pain (lbp). engaging in an active lifestyle is associated with a better prognosis. nevertheless, there is evidence to suggest that patients with chronic lbp are less likely to meet recommended physical activity levels. furthermore, while exercise therapy has been endorsed by recent clinical practice guidelines, evidence from systematic reviews suggests that its effect on pain and disability are at best moderate and n ... | 2018 | 29334992 |
| thioredoxin-1 negatively modulates adam17 activity through direct binding and indirect reductive activity. | a disintegrin and metalloprotease 17 (adam17) modulates signaling events by releasing surface protein ectodomains such as tnfα and the egfr-ligands. we have previously characterized cytoplasmic thioredoxin-1 (trx-1) as a partner of adam17 cytoplasmic domain. combining discovery and targeted proteomic approaches, we uncovered that trx-1 negatively regulates adam17 by direct and indirect effect. we performed cell-based assays with synthetic peptides and site-directed mutagenesis and we demonstrate ... | 2018 | 29334756 |
| polyoxygenated cyclohexenoids with promising α-glycosidase inhibitory activity produced by phomopsis sp. ye3250, an endophytic fungus derived from paeonia delavayi. | seven new polyoxygenated cyclohexenoids, namely, phomopoxides a-g (1-7), were isolated from the fermentation broth extract of an endophytic fungal strain phomopsis sp. ye3250 from the medicinal plant paeonia delavayi franch. the structures of these compounds were established by spectroscopic interpretation. the absolute configurations of compounds 1 and 4 were confirmed by x-ray crystallographic analysis and chemical derivative approach. all isolated compounds showed weak cytotoxic activities to ... | 2018 | 29334729 |
| lithium, a classic drug in psychiatry, improves nilotinib-mediated antileukemic effects. | although tyrosine kinase inhibitors (tkis) that target bcr-abl play a key role in chronic myeloid leukemia (cml) therapy, they do not eradicate cml-initiating cells, which lead to the emergence of drug resistance. here we used the lithium, a gsk-3 inhibitor, to attempt to potentiate the effects of nilotinib against leukemia cells. for this purpose, a k562 leukemia cell line and bone marrow cells from untreated chronic myeloid leukemia (cml) patients, prior to any exposure to tkis, were used as a ... | 2018 | 29334667 |
| depletion study, withdrawal period calculation and bioaccumulation of sulfamethazine in tilapia (oreochromis niloticus) treated with medicated feed. | the residue depletion of sulfamethazine (smz) was evaluated in tilapia (oreochromis niloticus) after 11 days of administration of medicated feed containing smz, at the dose of 422 mg/kg body weight (bw). the determination of smz in feed and tilapia fillet was carried out using the quechers approach for sample preparation, and high performance liquid chromatography with diode array detector (hplc-dad) and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (up ... | 2018 | 29334653 |
| antimicrobial and stress responses to increased temperature and bacterial pathogen challenge in the holobiont of a reef-building coral. | global increases in coral disease prevalence have been linked to ocean warming through changes in coral-associated bacterial communities, pathogen virulence and immune system function. however, the interactive effects of temperature and pathogens on the coral holobiont are poorly understood. here, we assessed three compartments of the holobiont (host, symbiodinium, bacterial community) of the coral montipora aequituberculata challenged with the pathogen vibrio coralliilyticus and the commensal b ... | 2018 | 29334418 |
| unearthing belowground bud banks in fire-prone ecosystems. | despite long-time awareness of the importance of the location of buds in plant biology, research on belowground bud banks has been scant. terms such as lignotuber, xylopodium and sobole, all referring to belowground bud-bearing structures, are used inconsistently in the literature. because soil efficiently insulates meristems from the heat of fire, concealing buds below ground provides fitness benefits in fire-prone ecosystems. thus, in these ecosystems, there is a remarkable diversity of bud-be ... | 2018 | 29334401 |
| smartphone integrated optoelectrowetting (sioew) for on-chip sample processing and microscopic detection of water quality. | with the increasing capabilities and ubiquity of smartphones and their associated digital cameras, this study presents a smartphone integrated optoelectrowetting (sioew) device as a simple, portable tool capable of on-chip water sample preparation and microscopic detection of the target cells in water samples, which significantly reduce the detection time and the labor cost required for water quality monitoring. a commercially available smartphone is used as a low-intensity portable light source ... | 2018 | 29334390 |
| dna barcoding for species identification in deep-sea clams (mollusca: bivalvia: vesicomyidae). | deep-sea clams (bivalvia: vesicomyidae) have been found in reduced environments over the world oceans, but taxonomy of this group remains confusing at species and supraspecific levels due to their high-morphological similarity and plasticity. in the present study, we collected mitochondrial coi sequences to evaluate the utility of dna barcoding on identifying vesicomyid species. coi dataset identified 56 well-supported putative species/operational taxonomic units (otus), approximately covering h ... | 2018 | 29334293 |
| persistence of hepatitis b immune memory until 9-10 years of age following hepatitis b vaccination at birth and dtap-ipv-hb-prp∼t vaccination at 2, 4 and 6 months. | to evaluate the long-term persistence of anti-hepatitis b surface (hbs) antibodies and the response to a hb challenge re-vaccination in children who had received a primary series of dtap-ipv-hb-prp∼t (hexaxim™) or dtap-ipv-hb/prp∼t (infanrix hexa™). | 2018 | 29333947 |
| myotropic activity and immuno-localization of selected neuropeptides of the burying beetle nicrophorus vespilloides (coleoptera: silphidae). | burying beetles (nicrophorus sp.) are necrophagous insects with developed parental care. genome of nicrophorus vespilloides has been recently sequenced, which makes them interesting model organism in behavioural ecology. however, we know very little about their physiology, including the functioning of their neuro-endocrine system. in this study, one of the physiological activities of proctolin, myosuppressin (nicve-ms), myoinhibitory peptide (trica-mip-5) and the short neuropeptide f (nicve-snpf ... | 2018 | 29333681 |