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effects of milbemycin oxime on adult hookworms in dogs with naturally acquired infections.previous work indicated that adult ancylostoma caninum can be removed from experimentally infected dogs, using a formulation of milbemycin oxime at dosage of 0.5 mg/kg of body weight. to determine the efficacy of this treatment in dogs naturally infected with adult hookworms, 24 mixed-breed dogs with patent hookworm infections were purchased from an out-of-state vendor, and 6 male and 6 female dogs were assigned to either a control group or a group that would be treated. dogs were treated 10 day ...19902316928
human eosinophilic enteritis caused by dog hookworm ancylostoma caninum.an epidemic of eosinophilic enteritis (93 cases) has occurred in townsville, northern queensland, australia. a hookworm was found attached to a resected, inflamed ileal segment from 1 patient but the species could not be identified. an adult hookworm of species ancylostoma caninum was recovered at colonoscopy from the terminal ileum of a later patient. all of 38 patients interviewed in an epidemiological survey described behaviour which could have exposed them to infective larvae of this widespr ...19901971376
efficacy of nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths.nemadectin, a new broad-spectrum endectocide, was highly efficacious against natural infections of all the major canine gastrointestinal helminths. at single oral dosages of 0.2-0.4 mg kg-1 body weight (bw), a liquid formulation administered in gelatin capsules was 100% effective in eliminating natural infections of toxocara canis, toxascaris leonina, ancylostoma caninum and uncinaria stenocephala. tablets (267 mg) containing 4.6% nemadectin given at a rate of 1/3 tablet per 20 kg bw (0.2 mg nem ...19892617829
enzymes activity and worm burden in intestine and liver of mice infected with single doses of ancylostoma caninum larvae.transaminases increased significantly in the intestine and liver of mice infected with 500, 1,000 and 2,000 doses of ancylostoma caninum larvae. the level of increase remained higher than those of controls throughout the experimental period. the rise of enzymes was mainly due to the pathological changes caused by the migrating larvae within the organs.19892625550
a survey of helminths in domestic cats in the pretoria area of transvaal, republic of south africa. part 1: the prevalence and comparison of burdens of helminths in adult and juvenile cats.the helminths found in 1,502 necropsied cats were examined. the findings indicated that 65% of the cats were infested. the most prevalent helminths encountered were ancylostoma tubaeforme (41%), ancylostoma braziliense (25%), dipylidium caninum (23%), toxocara cati (11%), taenia taeniaeformis (7.7%), ancylostoma caninum (3.3%), joyeuxiella fuhrmanni (2.5%), ancylostoma ceylanicum (1.4%), and physaloptera praeputialis (1.3%). the following helminths were recorded in fewer than 1% of the cats: cen ...19892634770
ancylostoma caninum in british greyhounds. 19892718327
efficacy of ivermectin in hookworms as examined in ancylostoma caninum infections.single oral doses of ivermectin were given to dogs with moderate or heavy infections of ancylostoma caninum (egg counts ranging from 7,100 to 41,700 eggs/g feces) at 100, 50, 30, or 10 micrograms/kg body weight. each of these dosages was effective in clearing the infection completely, so that numerous worms were passed in the feces on days 1-3, but no worm was recovered from the intestinal tract at necropsy on day 4 after treatment. in contrast, an average of 178 worms per dog was recovered at n ...19892723924
a preliminary study on the use of enzyme-linked immunosorbent assay (elisa) for detection of trichinella spiralis infections in dogs.an enzyme-linked immunosorbent assay (elisa) was developed to detect trichinella spiralis infections in dogs using rabbit anti-canine igg-horseradish peroxidase prepared according to the improved periodate method and an antigen purified from t. spiralis larvae by sephadex g-200 chromatography. sixty-six canine sera were tested for trichinosis by the elisa and it showed a detection rate which was significantly higher than that by trichinoscopy. this antigen of t. spiralis appeared not to cross-re ...19892741302
[the effect of ivermectin on reactivated somatic larva of ancylostoma caninum ercolani 1859 (ancylostomidae) in the pregnant dog].it was evaluated by means of a controlled test to what extent reactivated larvae of ancylostoma caninum were influenced by single or double treatment with ivermectin. the investigations were done with a total of ten experimentally infected bitches. the single treatment of dams two to ten days ante partum with 0.5 mg or 1 mg ivermectin per kg bodyweight reduced the wormburden of their puppies on an average by 96.6% and 98.5%, respectively. the double treatment with 0.5 mg/kg bodyweight ante and p ...19892763759
musca domestica as a carrier of intestinal helminths in calabar, nigeria.a study was undertaken to examine the role of musca domestica as a carrier of intestinal helminths in calabar, nigeria. a total of 5000 house-flies were collected from markets and residential areas and examined for helminthic parasites using centrifugation, dissection and direct smear methods. four helminths were observed with the following frequency of infection on their external surfaces and gastrointestinal tracts respectively: ascaris lumbricoides ova (0.20% and 0.81%), strongyloides stercor ...19892791934
comparison of immune response in swiss albino mice due to single and repeated doses of infective ancylostoma caninum larvae after subcutaneous inoculation.migratory behaviour of ancylostoma caninum larvae and host responses were studied in four groups of swiss albino mice infected subcutaneously with single doses of 1,000, 2,000 and multiple doses of 500 + 500, 500 + 500 + 1,000. after the 1st day most of the larvae found in muscles in all the groups. there is no significant difference in the migratory behaviour and/or the adoptive pattern of larvae in both the singly and multiply infected animals.19892809186
efficacy of various anthelmintics against third-stage larvae of ancylostoma caninum in the brain of mice.in an experimental larval infection of ancylostoma caninum in mice, the efficacy of various anthelmintics against the larvae migrated and established in the brain is reported for the first time. albendazole and flubendazole were the most effective drugs. thiabendazole, benacil, phenacizole, oxfendazole and mebendazole showed significant larvicidal activity. tetramisole, levamisole, fenbendazole, sch 18099, pyrantel pamoate, morantel tartrate and oxantel pamoate did not show any significant activ ...19883372978
transmission of ancylostoma caninum and alaria marcianae in coyotes (canis latrans).one of seven female coyotes (canis latrans) captured in webb county, texas during september 1986 and confined and mated in holding facilities at millville, utah whelped the following spring. the maternal female (greater than 5-yr-old) and her five neonates were killed at 22 days postparturition. all were infected with adult ancylostoma caninum and were passing eggs in their feces. also, the neonates and maternal female were infected with immature and adult alaria marcianae, respectively. these f ...19883411716
serum enzymes and worm load in mice infected with repeated doses of ancylostoma caninum larvae.the alterations of serum enzymes induced in the host system of swiss albino mice by infection with ancylostoma caninum larvae have been studied in multiple doses of infection. it was found that the level of transaminases, alkaline phosphatase and amylase increased significantly throughout the infection period when compared with controls. in infected animals, increase of enzymes was influenced by the host-parasite interactions caused due to the retained concentration of larval antigens.19882457613
changes in serum enzyme activities in mice infected with single doses of ancylostoma caninum larvae.aspartate transaminase, alanine transaminase, alkaline phosphatase and amylase levels were significantly increased in experimental female swiss albino mice infected with single doses of 500, 1,000 and 2,000 larvae of ancylostoma caninum. increase of enzyme levels is due to the leakage of large amounts of enzymes into the blood. the necrosis of cells during intestinal and extra intestinal phases of ancylostomiasis in mice is directly responsible for the increase of enzymes.19872437181
maternal transmission by alaria marcianae (trematoda) and the concept of amphiparatenesis.the term amphiparatenic host was coined originally for hosts of alaria marcianae that as adults are paratenic hosts, but as juveniles serve as definitive hosts. in this study the concept of amphiparatenesis is placed in a theoretical context, maternal transmission shown to be the basic mechanism, and the concept extended to include toxocara canis, t. cati, t. pteropodis, neoascaris vitulorum, ancylostoma caninum, uncinaria lucasi, various species of strongyloides, pharyngostomoides procyonis, an ...19873572644
helminth parasites of the coyote (canis latrans) in tennessee.from 1980 to 1984, 267 coyotes (canis latrans) from tennessee were examined for helminth parasites. hearts were examined for the presence of dirofilaria immitis, diaphragms for trichinella spiralis, and digestive tracts for other helminths. six species were found including 5 nematodes (d. immitis, physaloptera rara, trichuris vulpis, ancylostoma caninum, and toxascaris leonina) and 1 cestode (taenia pisiformis). univariate and multivariate statistical techniques were used to assess parasite prev ...19873585628
[the effect of fenbendazole on resting somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) in the pregnant bitch]. 19873591107
[effects of various anti-hookworm drugs on the cholinesterase activity of necator americanus, ancylostoma duodenale, ancylostoma caninum and nippostrongylus braziliensis]. 19873621504
parasites of stray dogs in the rabat region, morocco.eighteen parasites were identified from 57 stray dogs from the urban and rural areas of rabat. the prevalence of the species of parasites was: ctenocephalides (c. canis, c. felis) 94.7%, rhipicephalus sanguineus 68.5%, linguatula serrata, babesia canis, isospora canis each 3.5%, toxocara canis 7%, dirofilaria immitis, taenia hydatigena, t. pisiformis each 12.3%, dipetalonema dracunculoides 10.5%, ancylostoma caninum 17.5% echinococcus granulosus 22.8%, toxascaris leonina 33.3%, dipylidium caninu ...19873675044
cell mediated immunity during experimental ancylostomiasis: a review.cell-mediated immunity is usually recognized only in a very small number of infections caused by helminths. the present review is engaged with some aspects of the cell-mediated immunity in infections caused by ancylostoma caninum. special attention is paid to the role of passive transfer of sensitized cells and serum. the paper is based on a series of own original investigations of the authors.19873323310
isolation of anthelmintic resistant ancylostoma caninum. 198716031355
efficacy of benzimidazoles against larval ancylostoma caninum infection in mice. 19863721357
the response of captive rodents to the migration of ancylostoma caninum larvae.the distribution of the larvae of ancylostoma caninum in tissues of captive wild rodents (rattus rattus) and the leucocytic and behavioural responses of these rodents were studied after experimental oral infection. there was a wide distribution of larvae in tissues with a preponderance of the larvae in the skeletal muscles of the anterior part of the body in older infection. the rats responded by an elevation of total leucocytes and eosinophils in blood, alternation of locomotory activity and be ...19863721358
serum levels of aspartate transaminase, alanine transaminase and worm burden in mice infected with ancylostoma caninum larvae.aspartate transaminase and alanine transaminase levels showed considerable increase during initial (1 to 9 days) period of infection in all the experimental groups of mice and their level reached higher values than in the controls. the increase of enzymes was influenced by the degree of retention of worm load and the immunological damage caused by ancylostoma caninum larvae within the host system.19863721359
the origin and some of the functions of smooth endoplasmic reticulum in ancylostoma caninum sperm cells. 19863744670
[method of the spread of larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) in the definitive host (beagle)]. 19863751391
the prevalence of parasitic helminths in stray dogs in the baghdad area, iraq.the prevalence of parasitic helminths in 20 stray dogs from the area of baghdad was recorded. taenia spp. were found in 12 dogs, dipylidium caninum in ten dogs, toxocara canis in eight dogs, ancylostoma caninum in seven dogs and echinococcus granulosus in five dogs. spirocerca lupi and dirofilaria immitis were found in three dogs, mesocestoides lineatus in two dogs and strongyloides stercoralis in one dog.19863800471
experimental infection of ancylostoma caninum in chickens: immunization through transfer of sensitized bursal cells.an attempt has been made to demonstrate the immune response in chickens to infection by the dog hookworm ancylostoma caninum following transfer of sensitized bursal cells from infected donor chickens. recipients were challenged with a dose of 500 larvae each, 1, 3 and 5 days after cell transfer. the immune response was found to be more pronounced in recipients challenged 5 days after cell transfer than in those challenged 1 or 3 days after transfer and those which received non-sensitized bursal ...19863805714
comparative histochemical studies of glycosidase activity in some helminths.comparative histochemical studies of glycosidase activity were carried out in clonorchis sinensis, eurytrema pancreaticum, fasciola hepatica, dipylidium caninum, hymenolepis nana, ascaris suum, toxocara canis, ancylostoma caninum, trichuris vulpis and dirofilaria immitis. the enzymes examined were: n-acetyl-beta-glucosaminidase (ec 3.2.1.30), beta-glucuronidase (ec 3.2.1.31) and beta-galactosidase (ec 3.2.1.23). there were variations in enzyme distribution and intensity among the species and als ...19863084622
biochemical and immunologic characterization of a major surface antigen of dirofilaria immitis infective larvae.a 35 kd major surface antigen of dirofilaria immitis third-stage larvae was characterized biochemically and immunologically. living larvae were iodinated by using iodo-gen, iodosulfanilic acid, lactoperoxidase-glucose oxidase, and bolton-hunter reagents. detergent extracts of larvae labeled by the first three methods showed one major 35 kd component and a number of smaller components of about 6 kd, as analyzed by one-dimensional sds-page. in contrast, extracts from larvae labeled with the bolton ...19862419445
specificity of scolex and oncosphere antigens for the serological diagnosis of taeniid cestode infections in dogs.groups of dogs raised free of helminths were monospecifically infected with the common nematodes toxocara canis, ancylostoma caninum and trichuris vulpis. serums from these dogs, and a group of dogs of unknown history but infected with dirofilaria immitis and dipylidium caninum, had levels of antibody to their homologous nematode antigens readily detectable by elisa. no cross-reactions were apparent when these serums were tested by elisa using oncosphere antigens of taenia hydatigena, t. pisifor ...19862421704
specific antibody responses in dogs experimentally infected with echinococcus granulosus.six dogs reared helminth-free were divided into 2 groups. four dogs were infected per os with 200,000 protoscoleces each of echinococcus granulosus and 2 were kept as uninfected controls. all the dogs were kept together until 32 days after infection, when 1 infected dog was killed, its intestine removed and the contents examined to confirm that the infection with e. granulosus had been successful. the remaining 3 infected dogs were transferred to high security housing and their feces inspected d ...19863953947
prenatal and lactational transmission of toxocara canis and ancylostoma caninum: experimental infection of the bitch before pregnancy. 19853980144
chemotactic attraction of infective hookworm larvae of ancylostoma caninum by a dog serum factor.infective hookworm larvae of ancylostoma caninum showed chemotaxis on agar plates in a dog serum gradient. this chemotactic behaviour remain unaltered using an ultrafiltrated serum fraction with a molecular weight less than 500. gelfiltration of this ultrafiltrated fraction revealed a factor with a molecular weight of 480 causing chemotaxis. the chemotactic activity of the factor was destroyed after a pronase treatment. we conclude that the factor could be a polypeptide.19854024709
anthelmintic efficacy of febantel combined with praziquantel in dogs.ninety-four dogs were randomly assigned to 1 of 6 groups (5 treated and 1 untreated control) for evaluation of anthelmintic efficacy. three anthelmintic formulations were studied: a febantel paste, a praziquantel paste, and a combination paste containing both active ingredients. treated dogs were dosed once daily for 3 days. the minimal effective dosages in combination were established as 10 mg of febantel and 1 mg of praziquantel/kg of body weight. at those dosages for the combination, 99.5% to ...19854030460
temperature-induced separation of larvae of uncinaria stenocephala from a mixed fecal culture containing ancylostoma caninum. 19854040166
experimental infection of pups with ancylostoma caninum-infected mouse tissues.migration and distribution of ancylostoma caninum larvae in the tissues of mice orally infected with 1000 larvae, and establishment of patent infection from the mice to the definitive host, were studied. larval yield from different organs of mice, after digestion with artificial gastric juice, indicated that the highest recovery was at 4 h post-infection (62.8%), and thereafter a slight decline occurred up until 30 days post-infection (51.5%). migration of larvae to the lungs occurred within 4 h ...19854049727
prenatal and lactational transmission of toxocara canis and ancylostoma caninum: experimental infection of the bitch at midpregnancy and at parturition. 19854066142
experimental infection of pups with ancylostoma caninum larvae from an abnormal host, the chicken.the migration and distribution of ancylostoma caninum larvae in the tissues of chickens, infected orally with 1,000 larvae, were studied. larval yield at necropsy from different organs after digestion with artificial gastric juice revealed a 62.9% recovery four hours after inoculation, followed by a sharp decline to 5.4% at 72 hours. larvae were found in the heart within four hours, the lungs within eight hours and the liver within 12 to 18 hours but no larvae were recovered from the spleen, kid ...19854093588
the efficacy of some newer broad spectrum anthelmintics against third-stage larvae of ancylostoma caninum in the mouse.the efficacy of eight anthelmintics against ancylostoma caninum larvae in the skeletal muscles of mice was evaluated. levamisole (5 x 40 mg/kg), thiabendazole (5 x 400 mg/kg), oxfendazole (5 x 100 mg/kg), albendazole (5 x 100 mg/kg), flubendazole (5 x 200 mg/kg), benacil (5 x 200 mg/kg) and phenacizole (5 x 200 mg/kg) showed marked larvicidal activity (98 to 99%). sch 18099 did not show larvicidal activity even at 5 x 400 mg/kg.19854093589
differences in lipid granulation as the basis for a morphologic differentiation between third-stage larvae of uncinaria stenocephala and ancylostoma caninum.differences in the distribution of lipid granules between unstained third-stage larvae of uncinaria stenocephala and ancylostoma caninum cultured at 15 c was found to be an effective means for differentiating these 2 species of canine hookworms. in contrast, larvae cultured at 22 c were less easily differentiated based on the distribution of lipid granules. after culturing at 15 c, third-stage larvae of u. stenocephala were motile and exhibited 32 well-demarcated intestinal cells which contained ...19854093808
dose-titration studies of ivermectin against experimental ancylostoma caninum and uncinaria stenocephala infections.dose-titration trials of ivermectin were conducted on pups with dual experimental infections of 4th-stage larvae or adult ancylostoma caninum and uncinaria stenocephala. ivermectin was administered orally or subcutaneously at dosages of 0.006, 0.012, or 0.024 mg/kg of body weight. maximal or near maximal (greater than or equal to 96% to 100%) anthelmintic effect was observed for both stages of development for each hookworm species by either route of administration at a dosage of 0.024 mg/kg. res ...19853839115
studies on the prevalence of gastro-intestinal helminths of dogs in calabar, nigeria.the results of investigational study to determine the prevalence of gastro-intestinal helminths of dogs in calabar, nigeria with particular emphasis on the effects of sex and age of the animals on the occurrence of these endoparasites are presented. of a total of 254 dogs sampled using saturated brime solution floatation method and formalin-ether sedimentation method, 223 (86.97%) were infected. a breakdown of the number of parasitized dogs shows that 180 (70.86%) were positive for ancylostoma c ...19853869127
comparative studies on the infestation of three different breeds of dogs by gastro-intestinal helminths.the findings of an investigation mounted to evaluate and compare the prevalence of parasitic gastro-intestinal helminth ova in three different breeds of dogs in calabar, nigeria are presented. results of the investigation indicate that in alsatians, 25% infestation with strongyloides stercoralis, 25% toxocara canis, 65% ancylostoma caninum were found, in crossbreed between alsatian and mongrel, 15.56% infestation with strongyloides stercoralis, 10.93% toxascaris leonina, 25% toxocara canis, 68.7 ...19853869810
isolation and characterization of a proteolytic enzyme from the adult hookworm ancylostoma caninum.the adult hookworm ancylostoma caninum releases a proteolytic enzyme which is thought to be essential for its adaption to parasitism. the protease was purified from parasite extracts by ion-exchange chromatography followed by gel filtration and hydrophobic interaction chromatography. the purified enzyme exhibited a molecular weight of 37,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and had an nh2-terminal sequence of arg-his-his-gln-pro-lys-val-ala-leu-leu-gly-ala-his-gly-gly ...19853888998
host immune response against homologous challenge infection of ancylostoma caninum larvae after application of effective anthelmintics.the development of immunity against ancylostoma caninum larval reinfection has been investigated in mice after the primary infection has been treated with an effective anthelmintics. experimentally a, caninum larvae infected mice treated with levamisole (5 x 40 mg/kg), thiabendazole (5 x 200 mg/kg), oxfendazole (5 x 100 mg/kg), or albendazole (5 x 100 mg/kg) when challenged with a. caninum larvae showed 47.77 to 55.81% larval reduction from the challenge dose indicating thereby the development o ...19846491275
population dynamics across selected habitat variables of the helminth community in coyotes, canis latrans, from south texas.the effects of selected intrinsic variables operating on host subpopulations and of extrinsic variables across the collective host population on the distributions of 10 common helminth species from coyotes in south texas were compared. the intrinsic variables of host sex and presence and severity of sarcoptic mange had little effect on the distributions of most helminth species. the combined influences of (1) seasonal changes across the collective host population and (2) host subpopulations deli ...19846512639
effect of spleen extracts on the immune response in chickens to ancylostoma caninum larvae.spleen extracts from wlh chickens nonsensitized and sensitized by repeated infections of ancylostoma caninum larvae were injected separately into isologous recipients. extracts from donors infected with repeated high dose (250 + 250 + 500) and low dose (125 + 125 + 250) of larvae induced a significant acquired protective immune response when compared to controls which received normal extracts. no significant difference was observed between the two experimental groups. the filariform ancylostoma ...19846527002
prevalence of toxocariasis and echinococcosis among dogs in the niger delta.a sample of 60 dogs in the port harcourt area of the niger delta was examined for intestinal parasites. the high prevalence rates of toxocara canis (56.6%) and echinococcus granulosus (85.0%) in the area are discussed in relation to public health. other parasites found in dogs include toxascaris leonina (3.3%), uncinaria stenocephala (70.0%), dipylidium caninum (88.3%), trichuris vulpis (56.7%), ancylostoma caninum (65.0%) and taenia hydatigenia (43.3%).19846530709
infectivity of ancylostoma caninum in dogs by different routes of inoculation.infectivity of a. caninum in dogs inoculated with 500 larvae by different routes (percutaneous, subcutaneous, intravenous, per os, through a stomach tube and foot pad) was studied by ascertaining the worm burden at necropsy 21-27 days post-infection. infection through foot-pads yielded the maximum number of worms. the percentage of worm establishment using foot-pad inoculation was 73.8%, followed by subcutaneous (49.0%), percutaneous (45.0%) and per os (35.0%) routes. these results show that act ...19846542725
serum protein profile of mice during infection with of ancylostoma caninum and after the administration of tetramisole and levamisole.serum protein changes in mice following ancylostoma caninum larval infection were observed as decrease in albumin, gamma globulin and increase in beta globulin. these serum protein components showed a tendency to return back to their normal levels after the administration of effective anthelmintic such as tetramisole or levamisole to the infected mice. the increased level of beta globulin after treatment although decreased but did not return to its normal level within 14 days observation period.19846084695
a possible explanation for the synergism between mixed t- and b- cell populations in mice adoptively immunized with ancylostoma caninum.ancylostoma caninum--mouse model was employed to study the cellular cooperation in the adoptive immune response. the syngeneic recipient mice were intraperitoneally injected once or twice with mixtures of thymus and bone marrow cells from infected (with 500 or 2000 larvae) and uninfected donors. the experimental recipients expelled and/or destroyed the challenge larval burden more readily and at a greater rate than the controls with unsensitized cells. the cooperation between sensitized thymus a ...19846335517
anthelmintic effect of febantel/praziquantel paste in dogs and cats.a paste formulation of 3.4% febantel and 0.34% praziquantel was given in soft food at a rate of 0.29 g/kg of body weight, once daily for 3 days to dogs and cats. eleven of 12 dogs were naturally infected with ancylostoma caninum, 10 with trichuris vulpis, 2 with toxocara canis, 5 with taenia sp, and 3 with dirofilaria immitis. ten of 11 cats were naturally infected with toxocara cati, 2 with ancylostoma tubaeforme, 3 with taenia sp, 5 with capillaria aerophila, and 1 with paragonimus kellicotti. ...19846703448
rapid expulsion of ancylostoma caninum larvae due to previous infection with hymenolepis nana deshelled eggs.mice initially infected with single and repeated doses of hymenolepis nana deshelled eggs produced rapid and significant expulsion of challenged ancylostoma caninum larvae. absolute protective response was observed 8 days after initial infection (at 96 hours after challenge) in both singly and repeatedly infected groups probably due to high titres of heterologous reacting antibodies.19846715879
blood sucking activities of hookworms. routes and quantities of blood loss in ancylostoma caninum, a duodenale and a ceylanicum infections. 19836413142
transfer of delayed hypersensitivity through repeatedly sensitized peritoneal exudate cells during experimental ancylostomiasis in mice.current investigations using sensitized peritoneal exudate cells from mice infected repeatedly with ancylostoma caninum larvae supply the evidence that these cells have the capability to transfer passive immunity to isogeneic recipients in contrast to normal cells from uninfected donors. high doses of sensitization to donors and a lapse of time between the expansion and proliferation of cells in the recipients provide a rather strong immunological readiness to expel/destroy the worm burden. the ...19836862315
experimental ancylostomiasis in chickens: effect of various dose of infective ancylostoma caninum larvae on their migration and distribution.white leghorn chickens, when infected with repeated doses of ancylostoma caninum larvae, expel the larvae at a faster rate than when infected with a single dose. this suggests that the initial dose induces some resistance in the host. an initial dose of 1000 and 2000 larvae, followed by a 2nd dose of the same order, induces resistance in the alimentary tract causing the entire larval burden either to migrate to other tissues (organs) or to be expelled in 24 h.19836873246
pattern of immune response in recipients after transfer of mesenteric lymph node cells sensitized with low and high doses of ancylostoma caninum.cellular immune response was detected in female swiss albino mice with mesenteric lymph node cells during ancylostoma caninum infection. sensitized lymphocytes responded vigorously to a. caninum antigens and it was found that the cells (singly or repeatedly) sensitized with either low or high doses could confer adoptive protective immunity in recipients later challenged with a single dose of 500 a. caninum larvae.19836629209
pulmonary superoxide dismutase activity in the mouse infected with ancylostoma caninum larvae.albino mice were infected per os with 1000 infective larvae of ancylostoma caninum and pulmonary superoxide dismutase activity was studied after completion of lung migration. the total superoxide dismutase activity per mg of lung protein was elevated by 15% in infected mice. of the two forms of superoxide dismutases studied, that containing cu-zn was elevated by 44%. this suggests that a. caninum in mice may result in histopathological changes leading to transient pulmonary oxygen toxicity.19836630995
ancylostoma caninum: a report on the peripheral eosinophilia in naive and immunized swiss albino mice.the number of peripheral eosinophils was counted in female swiss albino mice on 1, 4, 9, 16 and 30 days after infection with various single (500, 1000 and 2000) and weekly repeated (500 + + 500 + 1000, 1000 + 1000 and 1000 + 1000 + 2000) doses of filariform ancylostoma caninum larvae. the eosinophil response was significantly higher in infected than in uninfected mice and reached a peak on day 16 in naive and day 4 and 9 in immunized mice. immunized mice were significantly more eosinophilic than ...19836662410
endotube-brush border complexes dissected from the intestines of haemonchus contortus and ancylostoma caninum.a procedure for the blunt dissection of the syncytial intestine of haemonchus contortus to separate the endotube-brush border complex is described. a similar complex can be obtained from the partially cellular intestine of ancylostoma caninum. the structural features of the complexes from the two sources are compared. the main differences are in the retention of terminal bars by the endotube from a. caninum and in the extent and organization of the microfilaments associated with the basal side o ...19836684761
fenbendazole treatment of pregnant bitches to reduce prenatal and lactogenic infections of toxocara canis and ancylostoma caninum in pups.a granulated formulation of fenbendazole was tested in a total of 23 treated and control, pregnant, parasite-free beagle bitches experimentally infected with toxocara canis and ancylostoma caninum. the drug was administered to each treated bitch once daily in canned dog food at a dosage of 50 mg/kg body weight. each of 2 treatment regimens tested was initiated on the 40th day of pregnancy. one regimen involved daily treatment continuing through the 14th postpartum day, and it resulted in 89% few ...198312002591
the in-vitro interaction between several components of the canine immune system and infective larvae of ancylostoma caninum. 19826811999
evaluation of granulated fenbendazole as a treatment for helminth infections in dogs.a granulated formulation of fenbendazole was tested in 95 dogs harbouring naturally occurring infections of toxocara canis, ancylostoma caninum, trichuris vulpis, dipylidium caninum, and taenia spp and in 19 laboratory-reared beagle pups experimentally infected with toxascaris leonina. the drug was administered in moistened dry dog food or in canned dog food. in dosage titration and confirmational studies, using worm counts in naturally infected dogs, the drug was 98%-100% effective at a dosage ...19827056663
gonadectomy and survival of ancylostoma caninum (nematoda) filariform larvae in mice.gonadectomy reversed the susceptibility response of male and female swiss mice to ancylostoma caninum infection. orchiectomy decreased the survival of filariform larvae (p greater than 0.001 to less than 0.25), whereas ovariectomy increased it significantly (p greater than 0.001 to less than 0.01).19827060717
the intestinal helminths of the red fox and some other carnivores in southwest germany.in south-west germany between 1975 and 1980, 3,573 red foxes (vulpes vulpes), 84 badgers (meles meles), 47 stone martens (martes foina), and 387 cats (felis catus) were examined for intestinal helminths. in foxes the extent of infections was: taenia crassiceps 24%, t. polyacantha 8%, t. taeniaeformis 0.6%, t. serialis 0.5%, mesocestoides leptothylacus 20%, mesocestoides sp. 0.2%, toxocara canis 32%, toxascaris leonina 3%, uncinaria stenocephala 26%. one to three foxes harboured t. hydatigena, t. ...19827072323
effect of febantel against ancylostoma caninum and trichuris vulpis infections in dogs.febantel was administered as a 3.4% paste to 45 dogs infected with 1 or more nematode species, which included ancylostoma caninum and trichuris vulpis. dosage levels of 5, 10, or 15 mg/kg of body weight daily for 3 consecutive days for a total of 15, 30, or 45 mg/kg were administered. at 15 mg/kg, all dogs were completely cleared of all nematode and cestode infections, including a caninum, t vulpis, uncinaria stenocephala, toxocara canis, toxascaris leonina, taenia sp, and dipylidium caninum, ex ...19827103181
effect of immunosuppressants in mice: part i--promethazine hydrochloride and hydrocortisone acetate treatments during experimental infections of ancylostoma caninum and nematospiroides dubius. 19827106855
effect of repeatedly sensitized bursal extract on the resistance of wlh chickens to experimental infection of ancylostoma caninum larvae. 19827118369
experimental infection with ancylostoma caninum larvae in mice. vii. role of promethazine hydrochloride in the rejection of worm burden from the intestine.acquired resistance of female swiss albino mice (6 to 8 weeks old) to ancylostoma caninum infection was demonstrated by the transfer of mesenteric lymph node cells (mlnc) from resistant (sensitised and promethazine treated), sensitised and untreated and non-sensitised and untreated donors to normal recipients of the same isogeneic strain. mlnc from sensitised and promethazine treated donors were more effective in suppressing the rejection mechanism of worm burden in recipients in comparison to t ...19827119431
anthelmintic activity of closantel against ancylostoma caninum in dogs.the efficacy and minimum therapeutic dose of closantel, an injectable salicylanilide anthelmintic, was evaluated on adult ancylostoma caninum. doses of 7.5 and 10 mg/kg had a marked anthelmintic effect on adult stages, removing 99 and 98%, respectively. a second experiment tested the efficacy of closantel against hypobiotic larval stages of a. caninum. a dose of 20 mg/kg did not affect the abundance of arrested hookworm larvae or prevent their subsequent development, but it may have inhibited th ...19827119989
the function of microtubules during spermatogenesis of ancylostoma caninum.ancylostoma caninum spermatogonia appeared as unspecialized cells with large nuclei and little cytoplasm when examined by electron microscopy. mitochondria and ribosomes were numerous but endoplasmic reticulum of either the rough or smooth variety was rarely observed. microtubules were abundant but were mostly concentrated in areas where the cells connected with a central cytoplasmic core, or rachis. microtubules present elsewhere in the cytoplasm were not associated with any particular organell ...19827131187
development and fate of the membranous organelles in spermatozoa of ancylostoma caninum.during development membranous organelles first appeared in the primary spermatocytes of ancylostoma. they were derived from the golgi as two separate components. one component, an electron-dense spheroid, quickly fused with other newly-formed cup-shaped, membranous structures to form the asymmetrical organelles. initially the membranous organelles had a homogeneous matrix but later became filled with quantities to 6- 8-nm filaments. following the meiotic reduction divisions each cell assumed a b ...19827131188
acetylcholinesterase activity in different stages of ancylostoma caninum. 19827147012
ancylostoma caninum: adult worm removal, corticosteroid treatment, and resumed development of arrested larvae in dogs. 19827151941
the effect of ultrafiltrated and dialysed dog serum on the chemotaxis of infective hookworm larvae of ancylostoma caninum. 19827157942
gonadal hormones in experimental ancylostoma caninum infections in male swiss albino mice. 19827160962
gastrointestinal helminth parasites of dogs in the western area--freetown (sierra leone).a survey of faecal samples taken from 1277 dogs in the western area (freetown, sierra leone) revealed an infestation by ancylostoma caninum (46,1%), toxocara canis (13,5%), toxascaris leonina (5,9%), dipylidium caninum (3,8%), and spirocerca lupi (3,5%). sampling was made per rectum. the age of the dogs examined, both male and female, ranged from one month to fifteen years. the clinical picture of the dogs affected is described and methods of treatment are suggested.19827171367
determination of the specific gravity of certain helminth eggs using sucrose density gradient centrifugation.the specific gravities of ten species of helminth eggs were determined using sucrose density gradient centrifugation. fecal or egg concentrate was layered over a 3 to 54% sucrose density gradient. the gradient was then centrifuged at 800 g for 20 min, allowing 5 min for acceleration and 5 for deceleration. bands formed were identified and measured. refractive index was measured at the middle of narrow bands, or at the level at which the concentration of eggs was highest, in the case of wide band ...19826890102
activity of ivermectin against canine intestinal helminths.the anthelmintic activity of ivermectin was tested in 98 dogs against adult ascarids (toxocara canis, toxascaris leonina), hookworms (ancylostoma caninum, a braziliense), and whipworms (trichuris vulpis), and against experimentally induced infections (4th-stage larvae) of t canis and a caninum. dosage levels tested were single subcutaneous injections of 50, 100, 200, or 400 micrograms/kg of body weight with appropriate vehicle-treated controls. a minimum of 4 (usually 5) dogs were tested with ea ...19826897345
ancylostoma caninum: transfer of lymphoid cells from thymus and bone marrow and adoptive immunity in mice. 19826978858
ancylostoma caninum: immune response to and distribution pattern of larvae in mice with sensitized thymus and bone marrow cells.suspensions of thymus and bone marrow cells from swiss albino donor mice infected with a. caninum larvae were injected separately or together into syngeneic, nonimmune recipients which were subsequently challenged with the larvae. the transfer of adoptive immunity through these cells has been confirmed and a cooperation and/or complementation between these two types was also observed. these sensitized cells helped the recipients in expelling and/or destroying the challenge larvae more effectivel ...19826982914
[effect of various benzimidazole carbamates on somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) and toxocara canis werner 1892 (anisakidae). 3. immunofluorescent serological studies of antibody levels in treated and untreated dogs]. 19817027683
the migratory behaviour and survival pattern of ancylostoma caninum larvae in an adoptively immunised host. 19817228483
pharmacological estimation of histamine in the intestine of mice experimentally infected with repeated doses of ancylostoma caninum larvae.intestinal extracts from normal [uninfected] and experimental [infected with a repeated dose of 500 + 500 + 1000 ancylostoma caninum larvae] mice were bioassayed for histamine using isolated guinea pig ileum preparation. intestinal histamine level of experimental animals significantly increased on 5th [70 ng] and 30th [75 ng] day after the last stimulating dose of infection. the source of this excess histamine and its role in immunity have been discussed.19817229353
comparative anthelmintic efficacy of two schedules of mebendazole treatment in dogs.two schedules of anthelmintic oral treatment, using mebendazole powder, were compared in 73 dogs naturally infected with common helminth intestinal parasites. mebendazole powder was administered to 26 dogs at doses of 22 mg/kg once daily for 3 days and was compared with the same dose given only daily for 5 days into 23 dogs. the 24 other dogs were kept as controls and received a placebo treatment for 5 days. efficacy results for the 3-day treatment schedule of mebendazole were as follows: toxoca ...19817271006
effects of temperature and glucose concentration on glycogen synthesis in ancylostoma caninum. 19817275476
the behaviour of infective ancylostoma caninum larvae in serum gradients.experiments were carried out to investigate if sera of animal species other than dog are chemotactically active for infective larvae of ancyclostoma caninum. those sera were also found to contain such a factor(s), although the larvae were attracted significantly better by dog serum. how this chemotaxis might be applied to the in vivo situation, when infective a. caninum larvae penetrate the skin of dogs, is discussed.19817276506
[effect of various benzimidazole carbamates on somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) and toxocara canis werner 1782 (anisakidae). 1. studies in white mice]. 19817282180
anthelmintic efficacy of amoscanate (c 9333-go/cgp 4540) against various infections in rodents, dogs and monkeys.the anthelmintic activity of amoscanate (c 9333-go/cgp 4540) has been studied in experimental infections with the human hookworm, necator americanus, in hamsters; nematospiroides dubius, hymenolepsis nana and natural infections with syphacia obvelata in mice; ancylostoma caninum, a. ceylanicum in mongrel dogs; oesophagostomum apiostumum and strongyloides fuelleborni in rhesus monkeys. single oral doses of 30-60 mg/kg eliminated 94 to 99% of the total necator parasites in 37-day-old non-patent in ...19817283017
[effect of various benzimidazole carbamates on somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) and toxacara canis werner 1782 (anisakidae). 2. studies of pregnant bitches]. 19817293557
ancylostoma caninum: immunization through transfer of sensitized lymphoid cells & their effect on the expulsion and/or destruction of worm burden in swiss albino mice. 19817309160
the influence of thyroxine on the host-parasite relationship of ancylostoma caninum in swiss albino mice. 19817309337
experimental ancylostomiasis in swiss albino mice: adrenal and thyroid histopathology.remarkable hypertrophic changes were observed in the adrenal and thyroid glands of male mice after 7 to 16 days of infection with the filariform larvae of ancylostoma caninum, but not in females. the adrenal gland revealed enormous enlargement of cells in the zonae glomerulosa, fasciculata and medulla, and also the formation of big vacuoles in the glomerular zone, whereas the thyroid gland showed distinctly hypertrophied follicular epithelium with marked acolloidal condition and follicular mass ...19817310112
[visceral larva migrans caused by ancylostoma caninum]. 19817311953
[helminthes infections in the small intestine of stray dogs in ejungbu city, kyunggi do, korea]one hundred and two stray dogs in ejungbu city of kyunggi-do, korea were examined to reveal out the degree of natural helminthic infection of small intestine. helminthes were collected at autopsy, by scraping the intestinal contents. the collected worms were classified by their morphological characteristics. out of 102 examined, 72 dogs were infected with any helminthes. the common helminthes were dipylidium caninum (47%), ancylostoma caninum (26%), toxascaris leonina (16%) and toxocara canis (1 ...198112902719
[an epidemiological study on zoonoses in korea]helminthic zoonoses are of significant importance to the public health and to the socioeconomic consequences especially in lost-meat, animal products and animal labor. for past several decades in korea, it has been recognized that endoparasitic infections among domestic animals are extremely common and many of the helminth parasites of man have been acquired from, or are shared with domestic animals. however, there was no survey of a nationwide scale on the prevalence of animal helminthiasis; an ...198112902720
experimental infection of chickens with ancylostoma caninum: migration and distribution of larvae in tissues.two hundred one-day-old male white leghorn chickens (gallus domesticus) divided into 4 groups were inoculated with a single dose of 500, 1000, 2000 or 4000 filariform larvae of ancylostoma caninum. larval recoveries were made from different tissues at intervals from 4 hours to 72 hours after infection. larval migration in the heart took place within 4 hours in all the groups except group a with 500 larvae and in thoracic muscle at 8 hours. larvae also migrated into liver, lungs and neck muscle w ...19807410806
scanning electron microscopy of the penetration of newborn mouse skin by strongyloides ratti and ancylostoma caninum larvae.the scanning electron microscopical appearances of infective larvae of strongyloides ratti and ancylostoma caninum have been described. particularly noteworthy was the tail of s. ratti which was found to have a distal aperture surrounded by a row of eight projections. the penetration of larvae through newborn mouse skin was investigated. s. ratti larvae forced its way rapidly and directly through the stratum corneum. no larvae of a. caninum were observed in stages of partial penetration but the ...19807434072
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