Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| evaluation of cervical and anal intraepithelial neoplasia in women attending a sexually transmitted infection clinic. | the incidence of anal and cervical cancers and their precursors have increased in the past decades. women with hiv and sexually transmitted infections are at a higher risk. cervical human papilloma virus infection may serve as a reservoir and source of anal infection or vice versa. a higher incidence of anal cytological abnormality has been observed in patients with abnormal cervical cytology. | 2017 | 27297278 |
| [effectiveness of human papillomavirus genotyping for detection of high-grade anal intraepithelial neoplasia compared to anal cytology]. | the incidence of high-grade anal intraepithelial neoplasia (hgain) -with an aetiological based on high-risk types of human papillomavirus- is increasing in some high-risk groups. screening for hgain includes routine anal cytology and, more recently, hpv genotyping. the main objective of this study was to determine the sensitivity and specificity of anal cytology and hpv genotyping for the detection of hgain. | 2017 | 26976378 |
| cervical cancer screening practices, knowledge of screening and risk, and highly active antiretroviral therapy adherence among women living with human immunodeficiency virus in lima, peru. | cervical cancer (cc) is the leading cause of cancer death among peruvian women. awareness shown by women living with hiv (wlhiv) of their increased risk and papanicoloau (pap) smear frequency is understudied, particularly in peru. we assessed the uptake of guidelines-based cc screening practices and its associations with two predictors, knowledge of cc screening and risk and highly active antiretroviral therapy (haart) adherence, among wlhiv. collected by self-administered questionnaires from 20 ... | 2017 | 27789849 |
| anal intraepithelial neoplasia. | anal squamous cell cancer (scc) is a relatively uncommon cancer in the united states. anal scc has long been associated with human immunodeficiency virus (hiv) positivity and/or men who have sex with men. the incidence of anal scc has been increasing in both genders regardless of hiv status. few clinicians are aware that white women, when not controlling for gender and sexual preference together, have the highest incidence of anal scc. anal intraepithelial neoplasia (ain), dysplastic cells of th ... | 2017 | 27749636 |
| human papilloma virus infection and psoriasis: did human papilloma virus infection trigger psoriasis? | psoriasis is an autoimmune chronic inflammatory skin disease known to be triggered by streptococcal and hiv infections. however, human papilloma virus infection (hpv) as a triggering factor for the development of psoriasis has not been reported yet. we, hereby report a case of plaque type with inverse psoriasis which probably could have been triggered by genital warts (hpv infection) and discuss the possible pathomechanisms for their coexistence and its management. | 2017 | 26692619 |
| effect of antiretroviral therapy on mucocutaneous manifestations among human immunodeficiency virus-infected patients in a tertiary care centre in south india. | human immunodeficiency virus (hiv) infection produces a wide range of infectious and noninfectious dermatoses which correlate with the degree of immunodeficiency. since the introduction of highly active antiretroviral therapy (haart), there has been a dramatic decrease in the incidence of hiv-associated dermatoses. however, haart itself causes various cutaneous adverse drug reactions. | 2017 | 26692610 |
| an interesting finding in the uterine cervix: schistosoma hematobium calcified eggs. | schistosoma hematobium infection is an endemic parasitic disease in africa, which is frequently associated with urinary schistosomiasis. the parasite infection causes epithelial changes and disruption, facilitating the infection by the human papilloma virus and human immunodeficiency virus (hiv). the authors report the case of a 44-year-old african hiv-positive woman who presented an abnormal routine pap smear. colposcopy examination revealed dense acetowhite micropapillary epithelium covering t ... | 2017 | 26484333 |
| human papilloma virus and cervical cancer education needs among hiv-positive haitian women in miami. | haitian immigrant women, the largest growing black ethnic group in miami, experience the highest rates of cervical cancer and account for one of the largest populations diagnosed with human immunodeficiency virus/acquired immunodeficiency syndrome (hiv/aids) in south florida. using community-based participatory research methods, we conducted a pilot study to examine human papilloma virus (hpv)/cervical cancer knowledge and identify intervention preferences among hiv positive haitian women. | 2017 | 25864021 |
| hpv testing in first-void urine provides sensitivity for cin2+ detection comparable to a physician-taken smear or brush-based self-sample: cross-sectional data from a triage population. | to compare sensitivity of high-risk hpv (hrhpv) and genotype detection in self-collected morning (u1) and later (u2) urine samples, brush-based self-samples (ss) and physician-taken smears (pts) for detecting cin2+ in a colposcopic referral population. | 2017 | 28391609 |
| evolving disparities in the epidemiology of oral cavity and oropharyngeal cancers. | incidence rates of head and neck cancers (hnc) associated with human papillomavirus (hpva) infection are increasing while non-hpv-associated (non-hpva) hnc cancer rates are decreasing. as nearly all sexually active individuals will acquire an hpv infection, it is important to understand epidemiologic trends of hncs associated with this sexually transmitted disease. we analyzed seer 9 (1973-2012) and 18 data (2000-2012) for hpva hncs (oropharynx area; op) and non-hpva (oral cavity area; oc). inci ... | 2017 | 28391376 |
| reproductive health screening in women with autoimmune diseases. | although the female predominance of autoimmune diseases is not completely understood, sex hormones are thought to play a role. attention to lifelong reproductive health is especially important for women with autoimmune disorders. many of these women require long-term immunosuppressive therapy that may affect their ability to clear infections, including viruses, and may alter natural tumor surveillance mechanisms. as a result, women with autoimmune diseases may have different risks for common rep ... | 2017 | 28390560 |
| evaluation of the performance of human papillomavirus testing in paired urine and clinician-collected cervical samples among women aged over 30 years in bhutan. | urine sampling may offer a less invasive solution than cervical sampling to test for human papillomavirus (hpv) for hpv vaccine impact monitoring. | 2017 | 28390433 |
| concordance of hpv-dna in cervical dysplasia or genital warts in women and their monogamous long-term male partners. | transmission of human papillomavirus (hpv) is a premise for development of cervical dysplasia and genital warts. this cross-sectional study assesses concordance of hpv types present in genital warts or cervical dysplasia in women and genital infection of their monogamous male partners in conjunction with seroprevalence of hpv-6,-11,-16 and -18 antibodies. blood was taken from both women and men, as well a smear of the urogenital area of men. hpv dna detection in women was done in fixed paraffin ... | 2017 | 28390162 |
| genotypic diversity of anogenital human papillomavirus in women attending cervical cancer screening in harare, zimbabwe. | although anogenital cancers have been on a gradual rise in developing countries in the past few decades, they have been understudied. | 2017 | 28390142 |
| identification and characterization of enhancer agonist human cytotoxic t-cell epitopes of the human papillomavirus type 16 (hpv16) e6/e7. | human papillomavirus (hpv) is associated with the etiology of cervical carcinoma, head and neck squamous cell carcinoma, and several other cancer types. vaccines directed against hpv virus-like particles and coat proteins have been extremely successful in the prevention of cervical cancer through the activation of host hpv-specific antibody responses; however, hpv-associated cancers remain a major public health problem. the development of a therapeutic vaccine will require the generation of t-ce ... | 2017 | 28389098 |
| enhanced efficacy with reduced toxicity of chemotherapy drug 5-fluorouracil by synergistic treatment with abnormal savda munziq from uyghur medicine. | abnormal savda munziq (asmq) is a traditional prescription in uyghur medicine, and its treatment of complex diseases such as tumors and asthma has been proven to be effective in uyghur medical clinical practice. the efficacy-enhancing and toxicity-reducing properties of asmq were studied on mice with transplanted cervical cancer (u27) tumors, which were treated with 5-fluorouracil (5-fu) in this work. | 2017 | 28388901 |
| retrospective study of the influence of hpv persistence on outcomes among women with high-risk hpv infections and negative cytology. | to evaluate the outcomes of women diagnosed with high-risk hpv without cytology evidence of cervical dysplasia. | 2017 | 28388819 |
| hpv-negative penile squamous cell carcinoma: disruptive mutations in the tp53 gene are common. | the majority of penile squamous cell carcinomas is caused by transforming human papilloma virus (hpv) infection. the etiology of hpv-negative cancers is unclear, but tp53 mutations have been implicated. archival tissues of 108 invasive squamous cell carcinoma from a single pathology institution in a low-incidence area were analyzed for hpv-dna and p16(ink4a) overexpression and for tp53 mutations by ion torrent next-generation sequencing. library preparation failed in 32/108 squamous cell carcino ... | 2017 | 28387325 |
| multifocal epithelial hyperplasia. | multifocal epithelial hyperplasia is a rare disease associated with human papilloma virus types 13 and 32. diagnosis is based on clinical and histopathological findings, and most lesions are asymptomatic and regress spontaneously with time. the purpose of this paper is to describe a five-year-old girl who presented with multiple intraoral lesions on the buccal mucosa and tongue, which regressed spontaneously in 15 months. | 2017 | 28387191 |
| association between the p53 arginine/arginine homozygous genotype at codon 72 and human papillomavirus e6/e7 mrna expression. | to evaluate the association between p53 polymorphisms and human papillomavirus (hpv) e6/e7 mrna expression. | 2017 | 28347732 |
| long-term response in patient with recurrent oropharyngeal carcinoma treated with cetuximab, docetaxel and cisplatin (tpex) as first-line treatment followed by cetuximab maintenance. | cetuximab, an anti-egfr monoclonal antibody in combination with platinum and 5fu is the standard of care in first-line treatment of patients with recurrent head and neck squamous cell carcinoma (hnscc), with an expected median outcome of 10months. for this population, development of efficacious and safer therapies is still needed. | 2017 | 28347701 |
| human papillomavirus in cervical cancer and oropharyngeal cancer: one cause, two diseases. | human papillomavirus (hpv) causes greater than 5% of cancers worldwide, including all cervical cancers and an alarmingly increasing proportion of oropharyngeal cancers (opcs). despite markedly reduced cervical cancer incidence in industrialized nations with organized screening programs, cervical cancer remains the second most common cause of death from cancer in women worldwide, as developing countries lack resources for universal, high-quality screening. in the united states, hpv-related opc is ... | 2017 | 28346680 |
| eccrine syringofibroadenoma in association with acquired epidermodysplasia verruciformis. | a 75-year-old man with human immunodeficiency virus infection and numerous biopsy-proven warts for 10 years, refractory to cryosurgery, cimetidine, and topical imiquimod, presented with numerous pink to hypopigmented verrucous papules and plaques involving the face, trunk, buttocks, and groin. laboratory evaluation revealed a cd4 t-cell count of 62 cells per microliter and human immunodeficiency virus viral load of <117 copies per milliliter. biopsy of a plaque groin lesion was performed. histop ... | 2017 | 28346303 |
| committee opinion no. 704: human papillomavirus vaccination. | human papillomavirus (hpv) is associated with anogenital cancer (including cervical, vaginal, vulvar, penile, and anal), oropharyngeal cancer, and genital warts. the hpv vaccination significantly reduces the incidence of anogenital cancer and genital warts. despite the benefits of hpv vaccines, only 41.9% of girls in the recommended age group, and only 28.1% of males in the recommended age group have received all recommended doses. compared with many other countries, hpv vaccination rates in the ... | 2017 | 28346275 |
| oropharyngeal squamous cell carcinoma and hpv. systematic review on overall management. | oral human papillomavirus infection amplifies the risk for oropharyngeal cancer. human papillomavirus-associated cancers in otorhinolaryngology have typical characteristics. | 2017 | 28345518 |
| efficacy of loop electrosurgical excision procedure with cold coagulation for treating cervical intraepithelial neoplasia: a two center cohort study. | to evaluate the efficacy of loop electrosurgical excision procedure (leep) combined with cold coagulation for treating cervical intraepithelial neoplasia (cin). | 2017 | 28344962 |
| cervical cancer: prevention and early detection. | to review effective methods of prevention that can be used to control the incidence of cervical cancer and detection strategies that can identify the precancerous lesions before they become true cancer. | 2017 | 28343836 |
| human papilloma virus (hpv) infection leads to the development of head and neck lesions but offers better prognosis in malignant indian patients. | head and neck cancers constitute a multifactorial global disease burden and are associated with human papilloma virus (hpv) as a possible risk factor. the aim of the study is to understand the relationship between hpv and the development of head and neck lesions in indian patients. to this end, frequency of hpv was assessed in relation to different demographic and etiological features and correlated with patient survival. the prevalence of hpv significantly increased from mild dysplastic lesions ... | 2017 | 28343330 |
| recurrence patterns after a decreased dose of 40gy to the elective treated neck in head and neck cancer. | to investigate the patterns of regional recurrences with emphasis on recurrences in the electively irradiated lymph node regions after dose de-escalation to 40gy (eqd2gy) in head and neck cancer. | 2017 | 28342647 |
| treatment outcomes in veterans with hpv-positive head and neck cancer. | head and neck squamous cell carcinoma (hnscc) caused by the human papilloma virus (hpv) has an improved prognosis relative to hpv-negative tumors. patients with hpv-positive disease may benefit from different treatment modalities in order to optimize survival and quality of life. we sought to investigate hpv-positive hnscc within the military veteran population, and analyze the role of treatment modality in outcomes of patients with hpv-positive and hpv-negative tumors. | 2017 | 28342482 |
| heat-induced editing of hpv genes to clear mucocutaneous warts? | hyperthermia increases expression of the antiviral cellular factors apobec3a and apobec3g and induces g-to-a or c-to-t mutations in human papilloma virus cervical cell lines and genital warts. this unexpected effect of heat treatment correlated with regression of genital warts in a subset of patients, including at distant sites, suggesting that this effect may be mediated in part by antiviral as well as immunological mechanisms. | 2017 | 28340680 |
| the singular epidemiology of hpv infection among french guianese women with normal cytology. | in french guiana, cervical cancer is the second most frequent cancer in females. the objective of the present study was to describe the prevalence of hpv infections in women with normal cervical cytology living in the remote villages of french guiana. | 2017 | 28340612 |
| polymerase chain reaction human papillomavirus (hpv) detection and hpv genotyping in invasive cervical cancers with prior negative hc2 test results. | recently, three large chinese cohort studies showed that 7.5% to 15.5% of patients with cervical carcinoma had negative high-risk human papillomavirus (hrhpv) test results on prior cytology specimens. these studies raise the question as to whether these negative hrhpv results represent truly hrhpv-negative carcinomas or false-negative hrhpv test results due to limitations in the testing of cytology specimens. this is increasingly an important question with increasing push to use hrhpv testing al ... | 2017 | 28340235 |
| detection assay for hpv16 and hpv18 by loop‑mediated isothermal amplification with lateral flow dipstick tests. | cervical cancer is the third highest cause of death in developing countries and most commonly results from high‑risk human papillomavirus (hr‑hpv) infection. among hr‑hpv genotypes, hpv16 and hpv18 are the most prevalent in cervical cancers. therefore, the present study aimed to develop a detection assay for hpv16 and hpv18 infection using loop‑mediated isothermal amplification (lamp) with lateral flow dipstick (lfd) tests. this assay is a simplified, user‑friendly method for the visual detectio ... | 2017 | 28339040 |
| diagnostic accuracy of high-risk hpv dna genotyping for primary cervical cancer screening and triage of hpv-positive women, compared to cytology: preliminary results of the pipavir study. | the purpose of the presented pipavir (persistent infections with human papillomaviruses; http://www.pipavir.com ) subanalysis is to assess the performance of high-risk (hr) hpv-dna genotyping as a method of primary cervical cancer screening and triage of hpv positive women to colposcopy compared to liquid-based cytology (lbc) in an urban female population. | 2017 | 28337594 |
| duty to advocate: human papillomavirus vaccination. | despite the excellent benefit-to-risk ratio for human papillomavirus (hpv) vaccination and recommendations for its routine use from the advisory committee on immunization practices (acip), significant controversy surrounding hpv vaccination continues to exist. in light of this controversy and continued low rates of vaccination among u.s. adolescents, the pediatric pharmacy advocacy group (ppag) endorses the safety and efficacy of hpv vaccination and agrees with acip recommendations for protectio ... | 2017 | 28337085 |
| trends in genital warts diagnoses in new zealand five years following the quadrivalent human papillomavirus vaccine introduction. | to investigate whether changes in rates of genital warts diagnosis at auckland sexual health service (ashs), pre and post the quadrivalent human papillomavirus (4vhpv) vaccine introduction in late 2008, differed between clients vaccine-eligible and not eligible. | 2017 | 28337036 |
| comparison of cobas® hpv and anyplex™ ii hpv28 assays for detecting and genotyping human papillomavirus. | persistent infection with high-risk human papillomavirus (hpv-hr) is a recognized cause of cervical cancer. the aim of this study was to compare analytical and clinical performances of the cobas® hpv and anyplex™ ii hpv28 assays for hpv detection and genotyping. a total of 94 cervical samples were tested. for hpv-hr, the results agreed very well (94.68%), with 100% agreement when detecting cin2+. the anyplex™ ii hpv28 assay detected more genotypes than the cobas® hpv test, but their clinical per ... | 2017 | 28336133 |
| modulating the dna damage response to improve treatment response in cervical cancer. | cervical cancer is the fourth most common cause of cancer-related death in women worldwide and new therapeutic approaches are needed to improve clinical outcomes for this group of patients. current treatment protocols for locally advanced and metastatic disease consist of ionising radiation and chemotherapy. chemoradiation induces cytotoxic levels of dna double-strand breaks, which activates programmed cell death via the dna damage response (ddr). cervical cancers are unique given an almost excl ... | 2017 | 28336131 |
| human papillomavirus as prognostic marker with rising prevalence in neck squamous cell carcinoma of unknown primary: a retrospective multicentre study. | patients with neck squamous cell carcinomas of unknown primary tumour (nsccup) present with lymph node metastasis without evidence for a primary tumour. most patients undergo an aggressive multimodal treatment, which induces severe, potentially unnecessary toxicity. primary tumours of nsccup can be hidden in the oropharynx. human papillomavirus (hpv) is causally involved in a subgroup of oropharyngeal squamous cell carcinomas (opscc) associated with early lymph node metastasis and good prognosis ... | 2017 | 28335889 |
| genotype distribution characteristics of multiple human papillomavirus in women from the taihu river basin, on the coast of eastern china. | there is limited data on the genotype distribution of human papillomavirus (hpv) in the taihu river basin, home to 1.29 million people on the coast of eastern china. this study evaluated the prevalence and genotypes among different female age groups in this region. | 2017 | 28335818 |
| the burden of hpv-related diseases in italy, 2001-12. | human papillomavirus (hpv) infection is the main cause of cervical cancer and plays a relevant role in the development of genital warts and of the cancer of penis and anus, head/neck, oropharynx and genitourinary system. the aim of this study is the evaluation of hospitalizations due to hpv-related pathologies in 2001-12 in italy. | 2017 | 28334854 |
| association of hiv status with local immune response to anal squamous cell carcinoma: implications for immunotherapy. | the programmed cell death protein 1 (pd-1) and programmed death-ligand 1 (pd-l1) pathway play an important immunosuppressive role in cancer and chronic viral infection, and have been effectively targeted in cancer therapy. anal squamous cell carcinoma (scc) is associated with both human papillomavirus and hiv infection. to date, patients with hiv have been excluded from most trials of immune checkpoint blocking agents, such as anti-pd-1 and anti-pd-l1, because it was assumed that their antitumor ... | 2017 | 28334399 |
| adjuvant human papillomavirus vaccination for secondary prevention: a systematic review. | human papillomavirus (hpv) vaccination is recommended for children and younger adults but not older adults or those with prior hpv exposure, leaving a large portion of the population at risk for hpv-mediated disease. emerging data suggest a possible role for vaccination as an adjuvant treatment for individuals with hpv-related clinical disease. | 2017 | 28334393 |
| associations of human papillomavirus (hpv) genotypes with high-grade cervical neoplasia (cin2+) in a cohort of women living with hiv in burkina faso and south africa. | to describe associations of high-risk human papillomavirus (hr-hpv) with high-grade cervical intraepithelial neoplasia (cin2+) in women living with hiv (wlhiv) in burkina faso (bf) and south africa (sa). | 2017 | 28333966 |
| proteflazid® and local immunity in diseases caused by human papillomavirus, herpesvirus and mixed urogenital infections. | reporting of clinical trials results for proteflazid® in the drug formulation suppositories and vaginal swabs soaked in the solution of the drug to the local immunity of the female reproductive tract. | 2017 | 28333902 |
| clinician and patient acceptability of self-collected human papillomavirus testing for cervical cancer screening. | to evaluate clinician and patient attitudes toward home self-collected human papillomavirus (hpv) testing for cervical cancer screening. | 2017 | 28332888 |
| changing hpv vaccination rates in bisexual and lesbian women. | human papillomavirus (hpv) vaccination rates continue to be below national targets for women and lower in some sexual minorities. hpv is a primary causal agent in cervical cancer, from which members of the lesbian and bisexual community mistakenly believe they are at low risk. this study characterized rates of hpv vaccination in women based on their sexual orientation. | 2017 | 28332774 |
| practices and attitudes of missouri school nurses regarding immunization records and select immunizations of graduating high school seniors. | school nurses play a key role in maintaining a healthy student population, and one of their roles includes maintaining vaccination records. further, they can play an important role in advocating for human papillomavirus (hpv) and meningococcal vaccination for students. all missouri public high school nurses were sent an electronic survey addressing the knowledge, attitudes, and practices regarding immunization records and hpv and meningococcal vaccination of high school seniors. approximately 75 ... | 2017 | 28332065 |
| legislative activity related to the human papillomavirus (hpv) vaccine in the united states (2006-2015): a need for evidence-based policy. | state-based policies to mandate hpv vaccination are politically challenging and have received broad criticisms. there is a critical need to understand the legislative activities that underpin subsequent policy implementation. the objective of this policy analysis was to analyze state legislation that focused on hpv vaccination from 2006-2015. a content analysis was conducted among primary sources of legislative data from hpv vaccine-related bills, including using the national conference of state ... | 2017 | 28331378 |
| acitretin for the treatment of recalcitrant plantar warts. | plantar warts caused by human papilloma virus (hpv)may be challenging to treat when conventionalmodalities fail. we report a case of severely recalcitrantplantar warts, successfully treated with oral acitretinand topical 40% urea cream. | 2017 | 28329527 |
| increased hpv l1 gene methylation and multiple infection status lead to the difference of cervical epithelial cell lesion in different ethnic women of xinjiang, china. | human papillomavirus (hpv) l1 gene methylation deeply involved in the progression and heterogeneity of cervical cell epithelial lesions. the dna ploidy also represented the early lesions of cervical cell, and it was associated with different hpv infection status in different ethnic women. so, the research was to explore whether it was possible that hpv l1 gene methylation and hpv infection status as the risk factors to lead to the differences of cervical epithelial cells' lesions in different et ... | 2017 | 28328841 |
| human papillomavirus first and second generation vaccines -current status and future directions. | it has been more than 10 years that the first prophylactic papillomavirus vaccine became available, although distribution has been mainly limited to the more affluent countries. the first two vaccines have been a great success, hundreds of millions of women and a much smaller number of men have been vaccinated ever since. in a few countries with high vaccination coverage, in particular australia but also parts of great britain and others, clinical impact of vaccination programs is already visibl ... | 2017 | 28328521 |
| pembrolizumab for platinum- and cetuximab-refractory head and neck cancer: results from a single-arm, phase ii study. | purpose there are no approved treatments for recurrent/metastatic head and neck squamous cell carcinoma refractory to platinum and cetuximab. in the single-arm, phase ii keynote-055 study, we evaluated pembrolizumab, an anti-programmed death 1 receptor antibody, in this platinum- and cetuximab-pretreated population with poor prognosis. methods eligibility stipulated disease progression within 6 months of platinum and cetuximab treatment. patients received pembrolizumab 200 mg every 3 weeks. imag ... | 2017 | 28328302 |
| [assessment of the pilot program for cervical cancer screening by health visitors]. | within the tender (6.1.3.a-13/1-2013-0001) supported by the european union, we wished to involve health visitors into the organized cervical cancer screening program. | 2017 | 28328247 |
| hpv16 dna and integration in normal and malignant epithelium: implications for the etiology of laryngeal squamous cell carcinoma. | molecular evidence suggests that human papillomavirus (hpv) has a role in the etiology of oropharyngeal squamous cell carcinoma. however, the role of hpv in laryngeal squamous cell carcinoma (lscc) is unclear. | 2017 | 28327951 |
| whole-genome analysis of human papillomavirus types 16, 18, and 58 isolated from cervical precancer and cancer samples in chinese women. | human papillomavirus (hpv) types 16, 18 and 58 are ranked the top three high-risk hpv types for cervical intraepithelial neoplasia (cin) and invasive carcinoma. we aimed to evaluate the diversity of hpv16, hpv18, and hpv58 genetic variants by hpv capture technology combined with next generation sequencing. 295, 73, and 148 variations were observed in 51 hpv16, 7 hpv18, and 11 hpv58 genomes, respectively. hpv16 isolates were predominantly of the a variant lineage, and sublineage a4 (asian) was th ... | 2017 | 28325903 |
| current and emerging molecular tests for human papillomavirus-related neoplasia in the genomic era. | laboratory tests have a key role in preventing human papillomavirus (hpv)-driven carcinomas and in guiding therapeutic interventions. an understanding of the virology, immunology, and carcinogenesis of hpv is essential for choosing appropriate diagnostic test modalities and developing new and even more effective cancer prevention strategies. hpv infects basal epithelial cells on multiple surfaces and induces carcinoma primarily in the cervix and the oropharynx. hpv types are stratified as high r ... | 2017 | 28325688 |
| hpv-16 variants' impact on uterine cervical cancer response to radiotherapy: a descriptive pilot study. | although the large impact of human papilloma virus (hpv) in cervical cancer is established, its place as a therapeutic target is new and according to the growing literature, could be promising. in the present study, radiosensitivity's difference based on hpv-16 variants is assessed. | 2017 | 28325620 |
| consensus statement from 17 relevant japanese academic societies on the promotion of the human papillomavirus vaccine. | 2017 | 28325478 | |
| the presence of human papillomavirus (hpv) in placenta and/or cord blood might result in th2 polarization. | the purpose of this study was to evaluate if an early exposure to human papillomavirus (hpv) during the prenatal period or infancy could result in hpv16-specific t helper (th) responses resembling those of adults with hpv-induced lesions. we tested hpv16-specific cell-mediated immunity (cmi) in children born with hpv-positive umbilical cord blood and/or placenta or having persistent oral hpv infection and in constantly oral hpv-negative controls. peripheral blood mononuclear cells from 33 childr ... | 2017 | 28324192 |
| cervical cancer screening intervals and management for women living with hiv: a risk benchmarking approach. | we suggested cervical cancer screening strategies for women living with hiv (wlhiv) by comparing their precancer risks to general population women, and then compared our suggestions with current centers for disease control and prevention (cdc) guidelines. | 2017 | 28323758 |
| the performance of human papillomavirus biomarkers in predicting anal high-grade squamous intraepithelial lesions in gay and bisexual men. | we evaluate the performance of human papillomavirus (hpv) biomarkers in prediction of anal histological high-grade squamous intraepithelial lesions (hsil) in gay and bisexual men (gbm) in sydney, australia. | 2017 | 28323757 |
| the prognostic value of extranodal extension in human papillomavirus-associated oropharyngeal squamous cell carcinoma. | extranodal (or extracapsular) extension (ene) is an adverse prognostic factor in patients with head and neck cancers who undergo primary surgery. however, the significance of ene in human papillomavirus (hpv)-positive oropharyngeal squamous cell carcinoma (opscc) is not well established, and single-institution studies have not established that ene predicts inferior outcome. the authors investigated the prognostic value of ene in hpv-positive patients who underwent primary surgery and whether adj ... | 2017 | 28323338 |
| the cost of implementing two small media interventions to promote hpv vaccination. | to estimate the cost of implementing lay health worker delivered print-based photonovella intervention and ipad-based tailored interactive multimedia intervention (timi) to promote human papillomavirus (hpv) vaccine uptake and completion among hispanic parents of daughters 9-17years old. | 2017 | 28322881 |
| a survey of wisconsin pediatricians' knowledge and practices regarding the human papillomavirus vaccine. | objective the human papillomavirus (hpv) is common and carries a significant burden of disease. this is increasingly apparent in males with the rising incidence of hpv-related oropharyngeal cancer. unfortunately, vaccination rates remain poor and are lowest in males. it is unclear if pediatricians are aware of the alarming rise of hpv-mediated head and neck cancers and the disproportionate effect on males. study design this investigation used a cross-sectional descriptive survey research design. ... | 2017 | 28322122 |
| hpv in larynx squamous cell carcinoma: new serotypes and survival study within 10-year follow-up. | objective to determine the presence of human papillomavirus (hpv) in head and neck squamous cell carcinoma, specifically in the larynx without the bias of other sublocations, and to describe the different serotypes of hpv and their impact on overall and disease-free survival after 10-year follow-up. study design retrospective case series with chart review of ear, nose, and throat oncologic database. setting academic tertiary care hospital. subjects a total of 123 samples of larynx squamous cell ... | 2017 | 28322111 |
| adolescent participation in hpv vaccine clinical trials: are parents willing? | approximately one-quarter of human papillomavirus (hpv) infections are acquired by adolescents, with a higher burden among racial/ethnic minorities. however, racial/ethnic minorities have been underrepresented in previous hpv vaccine trials. ongoing and future hpv vaccine optimization trials would benefit from racially- and ethnically-diverse sample of adolescent trial participants. this study examined factors influencing parental willingness to consent to their adolescents' participation in hpv ... | 2017 | 28321649 |
| hpv-independent differentiated vulvar intraepithelial neoplasia (dvin) is associated with an aggressive clinical course. | differentiated vulvar intrapeithelial neoplasia (dvin) is an human papillomavirus (hpv)-independent precursor of squamous cell carcinoma (scc), and the aim of this study was to better characterize its natural history. cases of dvin were identified from the pathology archives. outcomes of patients with dvin only, without associated invasive scc, were compared with a cohort of patients with high-grade squamous intraepithelial lesion [hsil(vin3)]. eighteen patients diagnosed with dvin with adjacent ... | 2017 | 28319571 |
| reactogenicity of cervarix and gardasil human papillomavirus (hpv) vaccines in a randomized single blind trial in healthy uk adolescent females. | one hundred and ninety eight females aged 12-15 y were enrolled in an observer-blinded randomized trial to assess the immunogenicity and reactogenicity of the tetravalent hpv vaccine gardasil® (group 2), in comparison to the bivalent hpv vaccine, cervarix® (group 1), which was routinely offered in the national vaccination schedule at the time. participants were blinded to treatment group until all 3 vaccinations had been given, while laboratory staff were masked during testing. for the majority ... | 2017 | 28319456 |
| oral viral infections: diagnosis and management. | this article focuses on common viral infections in the oral cavity with associated systemic manifestations. discussed are the clinical features, histopathology, diagnosis, treatment, and prevention of viral infections in oral cavity. this will be a useful aid for general practitioners and other dental personnel wanting to expand their pathologic knowledge. this article discusses herpes simplex, varicella zoster, mononucleosis, cytomegalovirus, enteroviruses, rubeola, rubella, mumps, and human pa ... | 2017 | 28317570 |
| epidemiology of oral and maxillofacial infections. | dental caries and periodontal disease are the most common dental infections and are constantly increasing worldwide. distribution, occurrence of dental caries, gingivitis, periodontitis, odontogenic infections, antibiotic resistance, oral mucosal infections, and microbe-related oral cancer are important to understand the public impact and methods of controlling such disease. distribution of human papilloma virus and human immunodeficiency virus -related oral cancers in the us population is prese ... | 2017 | 28317563 |
| sensitivity and specificity of antibodies against hpv16 e6 and other early proteins for the detection of hpv16-driven oropharyngeal squamous cell carcinoma. | to determine the sensitivity and specificity of hpv16 serology as diagnostic marker for hpv16-driven oropharyngeal squamous cell carcinoma (opscc), 214 hnscc patients from germany and italy with fresh-frozen tumor tissues and sera collected before treatment were included in this study. hundred and twenty cancer cases were from the oropharynx and 94 were from head and neck cancer regions outside the oropharynx (45 oral cavity, 12 hypopharynx and 35 larynx). serum antibodies to early (e1, e2, e6 a ... | 2017 | 28316084 |
| identification of an atypical etiological head and neck squamous carcinoma subtype featuring the cpg island methylator phenotype. | head and neck squamous cell carcinoma (hnscc) is broadly classified into hnscc associated with human papilloma virus (hpv) infection, and hpv negative hnscc, which is typically smoking-related. a subset of hpv negative hnsccs occur in patients without smoking history, however, and these etiologically 'atypical' hnsccs disproportionately occur in the oral cavity, and in female patients, suggesting a distinct etiology. to investigate the determinants of clinical and molecular heterogeneity, we per ... | 2017 | 28314692 |
| prevalence of cervical infection and genotype distribution of human papilloma virus among females in da nang, vietnam. | the goal of the present study was to determine the prevalence and distribution of high-risk human papilloma virus (hpv) genotypes in women from two districts in and around da nang city, vietnam. | 2017 | 28314288 |
| evaluation of p16/ki-67 dual-stained cytology as triage test for high-risk human papillomavirus-positive women. | the aim of this study was to evaluate the clinical utility of p16/ki-67 dual staining, for the identification of cin in high-risk hpv-positive women from a non-responder screening cohort. p16/ki-67 dual staining, pap cytology, and hpv16/18 genotyping were performed on physician-taken liquid-based samples from 495 women who tested high-risk hpv positive on self-sampled material (prohtect-3b study). different triage strategies involving p16/ki-67 dual staining were evaluated for sensitivity, speci ... | 2017 | 28304400 |
| influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the united states. | much of what is known about the significance of human papillomavirus (hpv) in oropharyngeal squamous cell carcinoma is derived from single-institution retrospective studies, post hoc analyses of tissue specimens from clinical trials, and tissue bank studies with a small sample size. the objective of this study is to investigate the impact of hpv on the frequency and clinical presentation of oropharyngeal carcinoma in a large, national sample with information from patients who underwent hpv testi ... | 2017 | 28304083 |
| e6/e7-p53-pou2f1-cthrc1 axis promotes cervical cancer metastasis and activates wnt/pcp pathway. | cervical cancer is an infectious cancer and the most common gynecologic cancer worldwide. e6/e7, the early genes of the high-risk mucosal human papillomavirus type, play key roles in the carcinogenic process of cervical cancer. however, little was known about its roles in modulating tumor microenvironment, particular extracellular matrix (ecm). in this study, we found that e6/e7 could regulate multiple ecm proteins, especially collagen triple helix repeat containing 1 (cthrc1). cthrc1 is highly ... | 2017 | 28303973 |
| multiplex polymerase chain reaction for the detection of high-risk-human papillomavirus types in formalin-fixed paraffin-embedded cervical tissues. | detecting high-risk-human papillomavirus (hpv) types has become an integral part of the cervical cancer screening programmes. this study aimed to develop a multiplex polymerase chain reaction (pcr) for identification of hpv types 16 and 18 along with the beta globin gene in formalin-fixed and paraffin-embedded cervical biopsy specimens. a total of 59 samples from patients with cervical abnormalities were tested. hpv 16 positivity was 50% in cervical cancers and 52.9% in cervical intraepithelial ... | 2017 | 28303830 |
| dysregulated expression of microrna-150 in human papillomavirus-induced lesions of k14-hpv16 transgenic mice. | high-risk human papillomavirus (hpv) infection is one of the major causes of infection-related cancers worldwide. micrornas (mirnas) are a family of non-coding rnas (ncrnas), whose dysregulated levels may cause an aberrant expression of genes involved in oncogenic pathways and consequently lead to cancer development. this is the case of the mirna-150 (mir-150), whose expression in hpv-induced lesions remains unclear and the present work aims to clarify it. we employed k14-hpv16 mice, which expre ... | 2017 | 28302562 |
| rna chromogenic in situ hybridization assay with clinical automated platform is a sensitive method in detecting high-risk human papillomavirus in squamous cell carcinoma. | detection of active human papillomavirus (hpv) is clinically important, as its presence has been shown to correlate with favorable clinical outcomes and better response to treatment in oropharyngeal squamous cell carcinomas (scc). using a clinical automated platform, we compared the performance of commercially available hpv dna and rna in situ hybridization (ish) probes in archival tissues of 57 scc. importantly, a clinical automated platform gives 1) consistent and reproducible results for hpv ... | 2017 | 28302536 |
| beneficial effects of a coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women. | to assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide, coriolus versicolor, asian centella, azadirachta indica and aloe vera on vaginal microbiota, cervical epithelization and vaginal health. | 2017 | 28302110 |
| target population for the screening of human papillomavirus (hpv) and anal carcinoma precursor lesions - results from a pilot study in hiv-infected males with sexual risk factors. | ninety-five percent of precursor lesions -high-grade squamous intraepithelial lesions (hsil) and anal intraepithelial neoplasms (ain)- and their progression to squamous anal cancer (ac) are induced by high-risk hpv (hr-hpv) serotypes 16 and 18. their incidence is higher particularly in hiv-infected male patients who have sex with other males (hiv-msm) (144/100,000/patients/year). | 2017 | 28301946 |
| human papillomavirus vaccination and genital warts in young indigenous australians: national sentinel surveillance data. | to examine the impact of the national human papillomavirus (hpv) vaccination program (available to girls and women [12-26 years] since 2007 and to boys [12-15 years] since 2013) on the number of diagnoses of genital warts in australian aboriginal and torres strait islander (indigenous) people. | 2017 | 28301790 |
| identification of optimal reference genes for normalization of rt-qpcr data in cancerous and non-cancerous tissues of human uterine cervix. | this study aimed to identify the most stably expressed reference genes from a panel of 32 candidate genes for normalization of reverse transcription-quantitative real-time polymerase chain reaction data in cancerous and non-cancerous tissues of human uterine cervix. overall, pum1, ywhaz, and rplp0 were identified as the most stably expressed genes in paired cancerous and non-cancerous tissues. the results were further stratified by the state of malignancy of the tissues, histopathological type o ... | 2017 | 28301252 |
| knowledge, attitude, and experience of cervical cancer and screening among sub-saharan african female students in a uk university. | cervical cancer is one of the major diseases that affect women of child bearing age. its main cause is the human papilloma virus; although, other associated factors have been evidenced to increase its risk. pap-smear screening and vaccination which has been shown to be successful in reducing the incidence and prevalence of the disease in developed countries, has been neglected in developing countries due to lack of knowledge, misconceptions, and cultural beliefs. | 2017 | 28300047 |
| 2017 | 28300000 | ||
| associations of foxp3 gene polymorphisms with severe recurrent respiratory papillomatosis in korean patients. | foxp3 is the most dependable marker for regulatory t cells which play a major role in immune tolerance. foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. we studied the association of foxp3 polymorphisms in severe rrp patients. | 2017 | 28298239 |
| cost-effectiveness of cervical cancer screening methods in low- and middle-income countries: a systematic review. | the incidence of cervical cancer in low- and middle-income countries (lmics) is five times higher than that observed in high-income countries (hics). this discrepancy is largely attributed to the implementation of cytology-based screening programmes in hics. however, due to reduced health system infrastructure requirements, hpv testing (self- and provider-collected) and visual inspection with acetic acid (via) have been proposed as alternatives that may be better suited to lmics. knowing the rel ... | 2017 | 28297074 |
| endocervical adenocarcinoma with morphologic features of both usual and gastric types: clinicopathologic and immunohistochemical analyses and high-risk hpv detection by in situ hybridization. | the fourth edition of the world health organization classification set up new entities of endocervical adenocarcinoma (eca), namely the "usual type" and "gastric type." these 2 types are considered to be distinct histogenetically because of their differing immunophenotypes, human papillomavirus (hpv) status, and prognoses. usual-type ecas (u-ecas) are virtually always associated with high-risk human papillomavirus (hr-hpv) infection. gastric-type ecas (g-ecas) are believed not to be associated w ... | 2017 | 28296678 |
| response to: hpv vaccine and autoimmunity incidence of new-onset autoimmune disease in girls and women with pre-existing autoimmune disease after quadrivalent human papillomavirus vaccination: a cohort study. | 2017 | 28295767 | |
| traf3/cyld mutations identify a distinct subset of human papilloma virus-associated head and neck squamous cell carcinoma. | the incidence of human papillomavirus (hpv)-associated (hpv-positive) head and neck squamous cell carcinoma (hnscc) of the oropharynx has dramatically increased over the last decade and continues to rise. newly diagnosed hpv-positive hnsccs in the united states currently outnumber any other hpv-associated cancers, including cervical cancer. despite introduction of the hpv vaccine, the epidemic of hpv-positive hnscc is expected to continue for approximately 60 years. compared with patients who ha ... | 2017 | 28295222 |
| genetic alterations in traf3 and cyld that regulate nuclear factor κb and interferon signaling define head and neck cancer subsets harboring human papillomavirus. | 2017 | 28295216 | |
| prevalence of human papillomavirus infection among chilean women from 2012 to 2016. | here, we evaluated the prevalence of human papillomavirus (hpv) in two groups of chilean women. the first group consisted of 3235 women aged 18-64 years attended in six primary care centers of santiago. the second group consisted of 456 women 18-85 aged who consulted the gynaecology department of the reference hospital of santiago. samples were collected from october 2012 to february 2016. cervical swabs were analyzed both hpv genotyping by pcr and reverse line blot, and cervical cytology by pap ... | 2017 | 28294358 |
| human papillomavirus prevalence in mouthwashes of patients undergoing tonsillectomy shows dominance of hpv69, without the corresponding finding in the tonsils. | the role of human papillomavirus (hpv) in tonsillar squamous cell carcinomas (tscc) is of interest, since a considerable proportion of tscc in sweden and other western countries is hpv positive. nevertheless, the natural history of hpv in normal tonsils, and the progression from localized infection to pre-malignant lesion to cancer are poorly understood. the aim of this study was to investigate whether hpv types found in mouthwash samples correlated to those in tonsillar tissue from the same ind ... | 2017 | 28293975 |
| influence of high risk hpv genotype on colposcopic performance: a large prospective study demonstrates improved detection of disease with zedscan i, particularly in non-hpv 16 patients. | to assess the influence of high-risk human papilloma virus (hrhpv) genotyping on the detection of high-grade disease (cin2+) using colposcopic impression both with and without electrical impedance spectroscopy (zedscan i) as an adjunct. | 2017 | 28292693 |
| human papillomavirus vaccine update. | rates of cancers attributable to human papillomavirus (hpv) are rising. a safe and extremely effective vaccine is available to prevent many of these cancers. studies have shown that health care providers' recommendation to immunize is the most important factor in parents' decision. parents of all adolescent boys and girls should receive a strong and unequivocal recommendation to vaccinate their child against hpv at the 11- or 12-year-old well child visit. ideally, adolescents complete their hpv ... | 2017 | 28292448 |
| transoral robotic surgery with radial forearm free flap reconstruction: case control analysis. | the resection of large oropharyngeal tumors traditionally involves a lip-splitting mandibulotomy for adequate margin visualization and free flap reconstruction of the surgical defect. transoral robotic surgery (tors) has emerged as a technique that can resect large and complex oropharyngeal tumors, avoiding a lip-splitting approach. the aim of this study is to compare the lip-splitting mandibulotomy approach versus tors for the management of advanced stage oropharyngeal carcinomas. | 2017 | 28292318 |
| performing piety in sexual health research: gender, health and evangelical christianities in a mexican human papillomavirus (hpv) study. | recent research suggests that health surveillance experiences like clinical trial participation might have unanticipated social consequences. i investigate how evangelical christians participating in longitudinal, observational sexual health research incorporate that long-term medical surveillance into their religious practice. this exploratory research focuses on mexican cristianos' participation in the cuernavaca arm of the multinational 'human papillomavirus in men' ('him') study, which teste ... | 2017 | 28292201 |
| hpv-transgenic mouse models: tools for studying the cancer-associated immune response. | for decades, research on the pathogenesis of papillomavirus-induced lesions, particularly of human papillomavirus (hpv) has relied on the use of animal models. among these, hpv-transgenic mice are some of the most frequently employed. after some initial unsuccessful attempts, researchers have succeeded in targeting the expression of one or more hpv-16 oncogenes to squamous epithelia, closely mimicking the lesions observed in cancer patients. the present review describes the relevance and usefuln ... | 2017 | 28385491 |