Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| synthesis of stable isotopically labeled peptides with filter-assisted enzymatic labeling for the diagnosis of hepatitis b virus infection utilizing mass spectrometry-based proteomics strategy. | a facile method for the preparation of stable isotopically labeled peptides was developed by means of filter-assisted tryptic (16)o/(18)o water labeling, which could be directly applied to the determination of hepatitis b virus infection from human serum with tandem mass spectrometry. tryptic peptides of hepatitis b surface antigen or hepatitis b e antigen from different subtypes of hepatitis b virus were synthesized with traditional solid-phase peptide synthesis as potential biomarkers. trypsin ... | 2017 | 28093123 |
| γδ t cells are indispensable for interleukin-23-mediated protection against concanavalin a-induced hepatitis in hepatitis b virus transgenic mice. | hepatitis b virus surface antigen (hbsag) carriers are highly susceptible to liver injury triggered by environmental biochemical stimulation. previously, we have reported an inverse correlation between γδ t cells and liver damage in patients with hepatitis b virus (hbv). however, whether γδ t cells play a role in regulating the hypersensitivity of hbsag carriers to biochemical stimulation-induced hepatitis is unknown. in this study, using hbv transgenic (hbs-tg) and hbs-tg t-cell receptor-δ-defi ... | 2017 | 28092402 |
| treatment of delta hepatitis: today and in the future - a review. | hepatitis delta virus (hdv) is a defective satellite virus and propagates in the presence of hepatitis b virus (hbv) surface antigen (hbsag). approximately 5% of the people who infected with hbv are also infected with hdv. chronic hepatitis caused by delta is the most severe form of chronic viral hepatitis including accelerated fibrosis, liver decompensation and development of hepatocellular carcinoma. interferon-based therapies still remain the only treatment option of the hepatitis delta. the ... | 2017 | 28092214 |
| matrix metalloproteinase 9 facilitates hepatitis b virus replication through binding with type i interferon (ifn) receptor 1 to repress ifn/jak/stat signaling. | hepatitis b virus (hbv) infection may cause acute hepatitis b, chronic hepatitis b (chb), liver cirrhosis, and hepatocellular carcinoma (hcc). however, the mechanisms by which hbv evades host immunity and maintains chronic infection are largely unknown. here, we revealed that matrix metalloproteinase 9 (mmp-9) is activated in peripheral blood mononuclear cells (pbmcs) of hbv-infected patients, and hbv stimulates mmp-9 expression in macrophages and pbmcs isolated from healthy individuals. mmp-9 p ... | 2017 | 28122987 |
| clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. | angiomyolipomas are rare neoplasms of mesenchymal origin and are derived from perivascular epithelioid cells. they usually develop in the kidney and rarely in the liver. due to their rarity, most hepatic angiomyolipomas have been misinterpreted as hepatocellular carcinoma (hcc) or other hypervascular liver tumours on imaging studies. we aimed to assess the clinico-pathological correlation of hepatic angiomyolipoma. | 2017 | 28122404 |
| effects of antiviral therapy on post-hepatectomy hbv reactivation and liver function in hbv dna-negative patients with hbv-related hepatocellular carcinoma. | the ability of antiviral therapy to reduce risk of post-hepatectomy hepatitis b virus (hbv) reactivation in patients negative for viral dna is unclear. this prospective study involved 174 consecutive patients with hepatitis b virus related hepatocellular carcinoma who were negative for hepatitis b virus dna in serum and who underwent hepatic resection. hepatitis b virus reactivation occurred in 30 patients in the non-antiviral group (27.8%) but in only 2 patients in the antiviral group (3.0%, p ... | 2017 | 28122361 |
| hepatitis delta and hiv infection. | viral liver diseases are frequent comorbidities and major contributors to death in hiv-positive individuals on antiretroviral therapy. although cure of hepatitis c and control of hepatitis b with antivirals avert liver disease progression in most hiv-coinfected patients, the lack of satisfactory treatment for hepatitis delta virus (hdv) infection remains a major threat for developing cirrhosis and liver cancer in this population. in the european union (eu) and north america, sexual contact has r ... | 2017 | 28121714 |
| seroepidemiology of hepatitis b and c virus infections among blood donors in ethiopia. | this study was conducted to investigate the prevalence of hepatitis b virus (hbv) and hepatitis c virus (hcv) infections among blood donors in different regions in ethiopia. a total of 56 885 sera were tested for hbsag and anti-hcv antibodies. of these, 3.9% were found hbsag-positive, 0.52% anti-hcv-positive, and 0.054% dual positive. hbv prevalence was relatively higher in adama (5.91%) than gondar (4.05%), jimma (3.87%), addis ababa (3.75%), and tigray (3.7%); and in males (4.64%) than females ... | 2017 | 28121005 |
| efficacy and safety of tenofovir in chronic hepatitis b: australian real world experience. | to evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world australian tertiary care setting. | 2017 | 28105258 |
| [mother-to-child transmission of hepatitis b virus despite postexposure prophylaxis: a review of the literature and description of 11 observations]. | chronic hepatitis b virus (hbv) infection leads to a risk of developing cirrhosis and hepatocellular carcinoma. in france, where the prevalence of hbv is low, mother-to-child transmission is the cause of chronic infection in more than one-third of cases. after exposure, the risk of chronic infection is the highest for newborns (90 %). the world health organization implemented a global immunization program in 1991, applied in france in 1994. a significant number of children are infected each year ... | 2017 | 28089231 |
| the nucleotide changes within hbv core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response. | we aimed to study the dynamic changes of hepatitis b virus (hbv) core promoter/precore (cp/prec) sequences during antiviral treatment and their associations with virological responses. | 2017 | 28088502 |
| anti-hepatitis b virus (hbv) response of imiquimod based toll like receptor 7 ligand in hbv-positive human hepatocelluar carcinoma cell line. | toll like receptors (tlrs) play an important role in innate immunity and various studies suggest that tlrs play a crucial role in pathogenesis of hepatitis b virus (hbv) infection. the present study aims in looking into the status of crucial host and viral gene expression on inciting tlr7. | 2017 | 28088184 |
| advances with using crispr/cas-mediated gene editing to treat infections with hepatitis b virus and hepatitis c virus. | chronic infections with hepatitis b and hepatitis c viruses (hbv and hcv) account for the majority of cases of cirrhosis and hepatocellular carcinoma. current therapies for the infections have limitations and improved efficacy is necessary to prevent complications in carriers of the viruses. in the case of hbv persistence, the replication intermediate comprising covalently closed circular dna (cccdna) is particularly problematic. licensed therapies have little effect on cccdna and hbv replicatio ... | 2017 | 28087399 |
| safety, tolerability, and antiviral effect of rg-101 in patients with chronic hepatitis c: a phase 1b, double-blind, randomised controlled trial. | mir-122 is an important host factor for hepatitis c virus (hcv) replication. the aim of this study was to assess the safety and tolerability, pharmacokinetics, and antiviral effect of a single dose of rg-101, a hepatocyte targeted n-acetylgalactosamine conjugated oligonucleotide that antagonises mir-122, in patients with chronic hcv infection with various genotypes. | 2017 | 28087069 |
| des-γ carboxyprothrombin may not be a good biomarker for hepatocellular carcinoma in those chronically infected with hepatitis b virus with basal core promoter double mutations (t^{1762}, a^{1764}), a prospective study. | the accuracy of des-γ -carboxyprothrombin (dcp) in the detection of hepatocellular carcinoma (hcc) in those infected hepatitis b virus (hbv) from cross-sectional or case-control studies is contradictory. | 2017 | 28085009 |
| outcome of anti-thymocyte immunoglobulin plus cyclosporine a for severe aplastic anaemia with chronic hepatitis b virus infection. | the influence of chronic hepatitis b virus (hbv) infection on the efficacy of intensive immunosuppressive treatment (ist) of severe aplastic anaemia (saa) patients remains unclear. previous reports on this topic have been mostly case reports or have had a relatively short follow-up. eight saa patients carrying chronic hbv infection and 24 matched patients without hbv at a ratio of 1:3 were included in this retrospective analysis. the patients were treated with anti-thymocyte globulin (atg) and c ... | 2017 | 28084534 |
| spontaneous mass and charge losses from single multi-megadalton ions studied by charge detection mass spectrometry. | spontaneous mass and charge losses from individual multi-megadalton ions have been observed with charge detection mass spectrometry (cdms) by trapping single hepatitis b virus (hbv) capsids for 3 s. gradual increases in the oscillation frequency of single ions in the ion trap are attributed mainly to mass loss (probably solvent, water, and/or salt). the total mass lost during the 3 s trapping period peaks at around 20 kda for 4 mda hbv t = 4 capsids. discrete frequency drops punctuate the gradua ... | 2017 | 28083758 |
| knowledge and attitudes toward hiv, hepatitis b virus, and hepatitis c virus infection among health-care workers in malawi. | the highest prevalence of hiv infection occurs in sub-saharan africa and hepatitis b virus (hbv), and hepatitis c virus (hcv) prevalence are the second highest in sub-saharan africa including malawi. health-care workers (hcws) play an important role in the prevention of, response to, and management of these infectious diseases. there is, however, no published research about the level of knowledge and attitudes toward hiv, hbv, and hcv infection among malawian hcws. the purpose of this study was ... | 2017 | 28083551 |
| correlates of hepatitis b virus-related stigmatization experienced by asians: a scoping review of literature. | although remarkable progress in the pharmacological components of the prevention and treatment of hepatitis b virus (hbv) and liver cancer has been achieved, hbv-related stigma is recognized as a major barrier to hbv management. the purpose of this revised social network model (rsnm)-guided review was to examine the existing research literature about hbv-related stigma among asians and asian immigrants residing in other countries. | 2017 | 28083549 |
| special issue on global health disparities focus on cancer. | haeok lee, phd, rn, faan who is a korean-american nurse scientist, received her doctor al degree from the nursing physiology department, college of nursing, university of california, san francisco (ucsf), in 1993, and her post doctor al training from college of medicine, ucsf. dr. lee worked at case western reserve university and university of colorado health sciences center. she has worked at the umass boston since 2008. dr. lee has established a long-term commitment to minority health, especia ... | 2017 | 28083546 |
| hmgb1-induced autophagy: a new pathway to maintain treg function during chronic hepatitis b virus infection. | high-mobility group box-1 (hmgb1) protein, as one of the well-known damage-associated molecular pattern molecules (damps), is enriched in chronic hepatitis b virus (hbv) infection and has a context-dependent role in autophagy, a highly conserved self-digestive process in response to environmental stress. recent mouse studies indicate that autophagy is highly active in regulatory t (treg)-cells. in the present study, we evaluated spontaneous and induced autophagy of peripheral treg cells from 98 ... | 2017 | 28082516 |
| the mthfr c677t mutation is not a risk factor recognized for hbv-related hcc in a population with a high prevalence of this genetic marker. | polymorphism of the methylenetetrahydrofolate reductase (mthfr) gene can affect disease progression in hbv infection. however, the results from different reports are inconsistent. the aim of this study was to investigate the association between the mthfr c677t polymorphism and the outcome of hbv infection in a tianjin han population. | 2017 | 28082187 |
| a collaborative study to establish the 3rd who international standard for hepatitis b virus for nucleic acid amplification techniques. | nucleic acid amplification techniques (nat) are routinely used for clinical diagnostics and monitoring hepatitis b virus (hbv) infections, and are implemented on a voluntary basis for blood screening. a collaborative study was performed to evaluate a replacement who international standard for hbv for the standardization of nat. two lyophilised hbv candidates were evaluated by 16 laboratories worldwide, alongside the existing hbv international standard. the overall mean potency estimates for the ... | 2017 | 28082100 |
| discovery of hepatitis b virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (gls4). | inhibition of hepatitis b virus (hbv) capsid assembly is a novel strategy for the development of chronic hepatitis b (chb) therapeutics. herein we described our lead optimization studies including the synthesis, molecular docking studies and structure-activity relationship (sar) studies of a series of novel heteroaryldihydropyrimidine (hap) inhibitors of hbv capsid assembly inhibitors, and the discovery of a potent inhibitor of hbv capsid assembly of gls4 (ethyl 4-[2-bromo-4-fluorophenyl]-6-[mor ... | 2017 | 28082068 |
| promoting effect of hepatitis b virus on the expressoin of phospholipase a2 group iia. | hepatitis b virus (hbv) infection causes acute and chronic liver disease, ultimately leading to the development of liver cirrhosis (lc) and hepatocellular carcinoma (hcc). phospholipase a2 group iia (pla2g2a) plays important roles in the development and progression of many tumors. thus far, there have been no reports on the association between hbv and pla2g2a. the present study investigated the effect of hbv infection on pla2g2a expression and its application in the diagnosis of hbv-related dise ... | 2017 | 28077172 |
| false positive hepatitis b virus core and surface antibodies due to intravenous immunoglobulin. | 2017 | 28076916 | |
| methotrexate-associated primary hepatic malignant lymphoma following hepatectomy: a case report. | recently, immunosuppressant-associated malignant lymphoma (ml) cases have been increasing along with the development of several effective immunosuppressant drugs for rheumatoid arthritis (ra). among methotrexate (mtx)-associated lymphoproliferative disorders, primary hepatic lymphoma (phl) in patients with ra following surgical resection has not been reported previously. | 2017 | 28076752 |
| coffee intake is associated with a lower liver stiffness in patients with non-alcoholic fatty liver disease, hepatitis c, and hepatitis b. | there is emerging evidence for the positive effects or benefits of coffee in patients with liver disease. we conducted a retrospective cross-sectional study on patients with non-alcoholic fatty liver disease (nafld), hepatitis c virus (hcv), and hepatitis b virus (hbv) infection to determine the effects of coffee intake on a non-invasive marker of liver fibrosis: liver stiffness assessed by transient elastography (te). we assessed coffee and tea intake and measured te in 1018 patients with nafld ... | 2017 | 28075394 |
| deubiquitylation of hepatitis b virus x protein (hbx) by ubiquitin-specific peptidase 15 (usp15) increases hbx stability and its transactivation activity. | hepatitis b virus x protein (hbx) plays important roles in viral replication and the development of hepatocellular carcinoma. hbx is a rapid turnover protein and ubiquitin-proteasome pathway has been suggested to influence hbx stability as treatment with proteasome inhibitors increases the levels of hbx protein and causes accumulation of the polyubiquitinated forms of hbx. deubiquitinases (dubs) are known to act by removing ubiquitin moieties from proteins and thereby reverse their stability and ... | 2017 | 28074857 |
| clinical features of hepatitis b and c virus infections, with high α-fetoprotein levels but not hepatocellular carcinoma. | the appropriate α-fetoprotein (afp) level to confirm hepatocellular carcinoma (hcc) could be 100 ng/ml; however, the clinical significance of falsely elevated afp in patients without hcc has not been fully studied. we investigated the clinical features and outcome of patients without hcc but with high afp levels (100 ng/ml), especially with chronic hepatitis b (chb) or c (chc).the sample included 124 consecutive patients with chb (n = 97) or chc (n = 27), with afp levels >100 ng/ml and without h ... | 2017 | 28079817 |
| a novel toolbox for the in vitro assay of hepatitis d virus infection. | hepatitis d virus (hdv) is a defective rna virus that requires the presence of hepatitis b virus (hbv) for its life cycle. the in vitro hdv infection system is widely used as a surrogate model to study cellular infection with both viruses owing to its practical feasibility. however, previous methods for running this system were less efficient for high-throughput screening and large-scale studies. here, we developed a novel method for the production of infectious hdv by adenoviral vector (adv)-me ... | 2017 | 28079152 |
| discovering potential serological biomarker for chronic hepatitis b virus-related hepatocellular carcinoma in chinese population by mal-associated serum glycoproteomics analysis. | the accuracy of current biomarkers for the diagnosis of hepatocellular carcinoma (hcc), especially chronic hepatitis b virus (hbv)-related hcc, is limited. recent progress in glycoproteomics has provided a novel platform for screening novel serological biomarkers of hcc. in this study, lectin affinity chromatography by maackia amurensis lectin (mal) and itraq combined with mass spectrometric analysis were performed to enrich and identify the glycoprotein fractions in serum samples from hbv-relat ... | 2017 | 28079114 |
| increasing lag-3 expression suppresses t-cell function in chronic hepatitis b: a balance between immunity strength and liver injury extent. | weak or absent virus-specific cd8 t-cell responses to hepatitis b virus (hbv) infection are thought to be responsible for persistent hbv infection. previous studies have indicated that multiple inhibitory receptors, including lymphocyte activation gene-3 (lag-3), can suppress the cd8 t-cell response in chronic viral infection. this study aimed to detect lag-3 expression and to investigate the manner in which the immune response is regulated to balance the strength of the response with the extent ... | 2017 | 28072682 |
| hepatitis b virus reactivation in breast cancer patients undergoing chemotherapy: a review and meta-analysis of prophylaxis management. | hepatitis b virus (hbv) reactivation during or after chemotherapy in patients with breast cancer has become a remarkable clinical problem. prophylactic nucleos(t)ide analogues (nas) are recommended for patients with breast cancer who are hepatitis b surface antigen (hbsag) positive before chemotherapy. we performed an up-to-date meta-analysis to compare the efficacy of prophylactic lamivudine use with nonprophylaxis in hbsag-positive breast cancer patients undergoing chemotherapy. pubmed, the co ... | 2017 | 28072494 |
| long-term liver diseases after initiation of antiretroviral therapy in hiv-infected patients with and without hbv or hcv coinfection. | coinfection of hepatitis b virus (hbv) or hepatitis c virus (hcv) with hiv is common and associated with increased mortality and increased risk of progression to chronic liver disease. we aimed to study long-term liver diseases after initiation of antiretroviral therapy (art) in hiv-infected patients with and without hbv or hcv coinfection. a retrospective cohort of 92 patients (32 patients with hbv and/or hcv coinfection) was analyzed. overall mean age was 38.3 years, and 54.3% were males. immu ... | 2017 | 28071205 |
| low level of hepatitis b virus infection in children 20 years after initiation of infant vaccination program in wallis and futuna. | the prevalence of hepatitis b virus (hbv) in wallis and futuna (waf) was one of the highest in the pacific and was the driving factor for introducing hepatitis b (hepb) vaccination in 1992 and hepb birth dose (hepb-bd) in 2006. using transmission assessment survey (tas) as a survey platform for eliminating lymphatic filariasis (lf), we assessed hbv surface antigen (hbsag) seroprevalence, hepb vaccination coverage, and its timeliness among schoolchildren in waf. from one finger prick of all regis ... | 2017 | 28070010 |
| semi-quantitative real-time pcr: a useful approach to identify persons with low replicative chronic hepatitis b. | antiviral therapy can be avoided during the low replicative phase of chronic hepatitis b virus (hbv) infection which is characterized notably by hbv dna concentration below 2000iu/ml. simplified diagnostic tests can improve access to hbv dna monitoring in resource-limited settings. the capacity of a new semi-quantitative real-time pcr approach based on sample-to-standard relative detection of the target to discriminate samples with hbv dna levels above or below the clinical threshold of 2000iu/m ... | 2017 | 28069472 |
| adolescent booster with hepatitis b virus vaccines decreases hbv infection in high-risk adults. | neutralizing antibodies (anti-hbs) after immunization with hepatitis b virus (hbv) vaccines against hbv surface antigen (hbsag) wane after 10-15years. we analyzed the effect of an adolescent booster given to vaccination-protected children born to mothers with different hbsag-carrying status against hbv infection in their mature adulthood. | 2017 | 28069363 |
| cpg methylation signature predicts recurrence in early-stage hepatocellular carcinoma: results from a multicenter study. | purpose early-stage hepatocellular carcinoma (e-hcc) is being diagnosed increasingly, and in one half of diagnosed patients, recurrence will develop. thus, it is urgent to identify recurrence-related markers. we investigated the effectiveness of cpg methylation in predicting recurrence for patients with e-hccs. patients and methods in total, 576 patients with e-hcc from four independent centers were sorted by three phases. in the discovery phase, 66 tumor samples were analyzed using the illumina ... | 2017 | 28068175 |
| hepatitis b vaccination in haemodialysis patients: an underestimated problem. factors influencing immune responses in ten years of observation in an italian haemodialysis centre and literature review. | despite universal infection control precautions, the risk of hepatitis b virus (hbv) infection in patients on chronic haemodialysis (hd) remains high. for this reason anti-hbv vaccination is recommended in these subjects. in hemodialyzed patients vaccinal response is often suboptimal and it's not clear what factors may influence it. | 2017 | 28067935 |
| hbv coinfection is associated with reduced cd4 response to antiretroviral treatment in pregnancy. | to evaluate the impact of hepatitis b virus (hbv) coinfection on response to antiretroviral treatment in pregnant women with hiv. | 2017 | 28067163 |
| alteration of methyl-cpg binding domain family in patients with chronic hepatitis b. | epigenetics contributes to the outcome of chronic hepatitis b virus (hbv) infection. however, the role of methyl-cpg binding domain (mbd) family in the natural history of chronic hepatitis b (chb) has not been demonstrated. it is aimed to investigate the dynamic expression of mbd family and assess the potential association of mbd family in the progression of chb. | 2017 | 28065745 |
| long-term effectiveness of plasma-derived hepatitis b vaccine 22-28 years after immunization in a hepatitis b virus endemic rural area: is an adult booster dose needed? | longan county is considered a highly endemic area for hepatitis b virus (hbv). the plasma-derived vaccine has been used in newborns in this area since 1987. a cross-sectional survey was conducted to evaluate the long-term effectiveness of this vaccine. in total, 1634 participants born during 1987-1993 and who had received a series of plasma-derived hb vaccinations at ages 0, 1, and 6 months were enrolled. serological hbv markers were detected and compared with previous survey data. overall the p ... | 2017 | 28065199 |
| activation of tnf-α-aid axis and co-inhibitory signals in coordination with th1-type immunity in a mouse model recapitulating hepatitis b. | hepatitis b virus (hbv) infection evokes host immune responses that primarily determine the outcome of hbv infection and the clinical features of hbv-associated liver disease. the precise mechanisms by which host factors restrict hbv replication, however, are poorly understood due to the lack of useful animal models that recapitulate immune responses to hbv. here, we performed comprehensive immunologic gene expression profiling of the liver of a mouse model recapitulating anti-hbv immune respons ... | 2017 | 28063995 |
| impact of hepatitis b core antibody seropositivity on the outcome of autologous hematopoietic stem cell transplantation for multiple myeloma. | hepatitis b core antibody (hbcab) seropositivity has been associated with a higher rate of hepatitis b virus (hbv) reactivation after chemotherapy, even in patients who are hepatitis b surface antigen (hbsag) negative. however, little is known about the risk of hbv reactivation after autologous hematopoietic stem cell transplantation (auto-hct). we evaluated the incidence of hbv reactivation, liver toxicity, and survival in patients with multiple myeloma (mm) who received auto-hct at our institu ... | 2017 | 28063964 |
| multiple slc and abc transporters contribute to the placental transfer of entecavir. | entecavir (etv), a nucleoside analog with high efficacy against hepatitis b virus, is recommended as a first-line antiviral drug for the treatment of chronic hepatitis b. however, scant information is available on the use of etv in pregnancy. to better understand the safety of etv in pregnant women, we aimed to demonstrate whether etv could permeate placental barrier and the underlying mechanism. our study showed that small amount of etv could permeate across placenta in mice. etv accumulation i ... | 2017 | 28062543 |
| characterization of the disassembly and reassembly of the hbv glycoprotein surface antigen, a pliable nanoparticle vaccine platform. | while nanoparticle vaccine technology is gaining interest due to the success of vaccines like those for the human papillomavirus that is based on viral capsid nanoparticles, little information is available on the disassembly and reassembly of viral surface glycoprotein-based nanoparticles. one such particle is the hepatitis b virus surface antigen (sag) that exists as nanoparticles. here we show, using biochemical analysis coupled with electron microscopy, that sag nanoparticle disassembly requi ... | 2017 | 28061386 |
| hepatitis b surface antigen promotes the invasion of hepatitis b virus-related hepatocellular carcinoma cells by upregulation of toll-like receptor 2. | hepatitis b virus (hbv) infection is one of the major risk factors leading to the development of hepatocellular carcinoma (hcc). hepatitis b surface antigen (hbsag) plays a pivotal role in hbv-related hcc pathogenesis, and toll-like receptor (tlr) 2 is also considered to mediate tumor progression. however, the interaction between hbsag and tlr2 in hcc progression remains unclear. thus, the aim of the study was to explore the effect of hbsag-tlr2 pathway on growth and invasion of hbv-related hcc ... | 2017 | 28061318 |
| serum microrna profiles as diagnostic biomarkers for hbv-positive hepatocellular carcinoma. | the discovery of effective and reliable biomarkers to detect hepatitis b virus (hbv)-positive hepatocellular carcinoma (hcc) at an early stage may improve the survival of hcc. the aim of this study was to establish serum microrna (mirna) profiles as diagnostic biomarkers for hbv-positive hcc. | 2017 | 28061012 |
| estimating the cost-effectiveness of one-time screening and treatment for hepatitis c in korea. | this study aims to investigate the cost-effectiveness of a one-time hepatitis c virus (hcv) screening and treatment program in south korea where hepatitis b virus (hbv) prevails, in people aged 40-70, compared to current practice (no screening). | 2017 | 28060834 |
| influences of obesity on the immunogenicity of hepatitis b vaccine. | hepatitis b vaccine is regarded as the most effective method for the prevention of hepatitis b virus (hbv) infection. however, several factors such as age, body mass index and immunocompetent state have been reported to be associated with reduced immunization responses. the present commentary was aimed to discuss the influences of obesity on the immunogenicity of hepatitis b vaccines. | 2017 | 28059607 |
| prognosis of intrahepatic cholangiocarcinomas with hbv infection is better than those with hepatolithiasis after r0 liver resection: a propensity score matching analysis. | the impact of different causative factors of intrahepatic cholangiocarcinoma (icc) on disease outcome remains largely unknown. this study aimed to evaluate the prognosis of icc patients with different pathogenic factors after hepatectomy. | 2017 | 28058554 |
| severe hepatitis b virus reactivation related to ibrutinib monotherapy. | 2017 | 28058492 | |
| hepatitis b virus strains from rwandan blood donors are genetically similar and form one clade within subgenotype a1. | rwanda is a central african country with about 12 million inhabitants. the 1994 genocide against the tutsi destroyed much of the infrastructure, including the health system. although this has improved significantly, many challenges remain to be addressed. in this study, the prevalence of serological markers of past and ongoing hepatitis b virus (hbv) infection and hbv vaccine related immunity was investigated in samples from blood donors from all regions of rwanda. | 2017 | 28056881 |
| platelet counts modulate the quantitative relationship between hepatitis b viral dna and surface antigen concentrations: a cross-sectional study of hematological, histological and viral factors. | the concentrations of hepatitis b virus (hbv) dna and surface antigen (hbsag) are two critical virological variables to be monitored in chronic hepatitis b. hbsag is derived from the hbv genome. thus, higher hbv-dna concentrations should implicate higher hbsag levels. nevertheless, the two variables do not manifest a simple linear relationship due to elusive host factor involvements. the aim of this study was to address the discrepancy of hbv dna and hbsag levels by a quantitative modeling of hb ... | 2017 | 28056849 |
| inhibiting the secretion of hepatitis b surface antigen (hbsag) to treat hepatitis b infection- a review. | chronic hepatitis b is a major global health issue, and has no known cure. currently there are over 240 million people infected with the disease, and it leads to the death of over 686,000 people each year. a total of seven treatments which help to control the disease are currently available: interferon-based treatments (pegasys, and interferon alpha), and nucleoside and nucleotide analogs (viread, baraclude, tyzeka, hepsera, epivir-hbv), but all require continuing treatment to maintain control o ... | 2017 | 28056752 |
| engineering hepatitis b virus core particles for targeting her2 receptors in vitro and in vivo. | hepatitis b virus core (hbc) particles have been studied for their potential as drug delivery vehicles for cancer therapy. hbc particles are hollow nano-particles of 30-34 nm diameter and 7 nm thick envelopes, consisting of 180-240 units of 21 kda core monomers. they have the capacity to assemble/dis-assemble in a controlled manner allowing encapsulation of various drugs and other biomolecules. moreover, other functional motifs, i.e. receptors, receptor binding sequences, peptides and proteins c ... | 2017 | 28056402 |
| mita/sting and its alternative splicing isoform mrp restrict hepatitis b virus replication. | an efficient clearance of hepatitis b virus (hbv) requires the coordinated work of both the innate and adaptive immune responses. mita/sting, an adapter protein of the innate immune signaling pathways, plays a key role in regulating innate and adaptive immune responses to dna virus infection. previously, we identified an alternatively spliced isoform of mita/sting, called mita-related protein (mrp), and found that mrp could specifically block mita-mediated interferon (ifn) induction while retain ... | 2017 | 28056087 |
| persistent risk for hepatocellular carcinoma after more than a decade of successful hepatitis b virus suppression. | 2017 | 28054479 | |
| hbx promotes cell proliferation by disturbing the cross-talk between mir-181a and pten. | hepatitis b virus x protein (hbx) is involved in the initiation and progression of hepatocellular carcinoma (hcc). however, the mechanism is still needed to be elucidated. in this study, we explored the relationship between hbx and microrna and their roles in hepato-carcinogenesis. firstly, by global microarray-based microrna profiling and qrt-pcr, we found mir-181a was strongly up-regulated in hepg2.2.15 cells (hbv positive) and phbv1.3-expressing hepg2 cells, and hbx played a major role in it. ... | 2017 | 28053323 |
| treatment of chronic hepatitis b infection-2017. | since the registration of the first effective nucleoside analogue against the hepatitis b virus almost two decades ago, major progress has been made in the management of chronic hepatitis b infection. however, hepatitis b-related morbidity and mortality remain a major global health threat. this is partly due to the escalating costs and the decrease in compliance related to the need for prolonged therapy for most patients who cannot be "cured". new biomarkers such as quantitative hepatitis b surf ... | 2017 | 28052634 |
| challenges in warranting access to prophylaxis and therapy for hepatitis b virus infection. | despite an available vaccine and efficient treatment for hepatitis b virus (hbv) infection, chronic hbv infection still remains a major global threat, and one of the top 20 causes of human mortality worldwide. one of the major challenges in controlling hbv infection is the high number of undiagnosed chronic carriers and the lack of access to prophylaxis and treatment in several parts of the world. we discuss relevant barriers that need to be overcome to achieve global control of hbv infection an ... | 2017 | 28052625 |
| novel targets for hepatitis b virus therapy. | treatment with either pegylated interferon-alpha (pegifn-α) or last generation nucleos(t)ide analogues (nas) successfully leads to serum viral load suppression in most chronically infected hepatitis b (chb) patients, but hbsag loss is only achieved in 10% of the cases after a 5-year follow-up. thus, therapy must be administered long-term and it will not completely eliminate infection because of the persistent hepatitis b virus (hbv) minichromosome in infected cells, and cannot completely abolish ... | 2017 | 28052622 |
| hepatitis b virus long-term impact of antiviral therapy nucleot(s)ide analogues (nucs). | the goal of antiviral therapy is to improve the quality of life and survival of patients with chronic hepatitis b (chb) by halting the progression to cirrhosis, end-stage liver disease or hepatocellular carcinoma (hcc), thus preventing anticipated liver-related death. oral administration of potent and less resistance-prone nucleot(s)ide analogues (nucs), such as entecavir (etv) and tenofovir disoproxil fumarate (tdf) has become the most popular treatment strategy worldwide because of their excel ... | 2017 | 28052621 |
| the impact of direct antiviral agents on the development and recurrence of hepatocellular carcinoma. | direct antiviral agents mark a major progress for the treatment of chronic hepatitis c virus infection. the rate of cure is higher than 90% in most populations and the safety profile is good. however, like any treatment, there are potential unexpected adverse events. several reports have indicated that antiviral therapy may be associated with the reactivation of hepatitis b virus or the emergence of herpes virus in a time-related manner. recently, several studies have described a potential unexp ... | 2017 | 28052619 |
| the future of liver transplantation for viral hepatitis. | in hepatitis c virus (hcv)-infected patients, transplantation can be justified by decompensated cirrhosis, hepatocellular carcinoma (hcc) or both. during the last decade, hcv infection accounted for about 30% of the indications for transplantation in europe and north america. direct antiviral agents (daas) are highly effective at curing hcv, even in patients with end-stage cirrhosis. in the future, the incidence of hcv-related decompensated cirrhosis will continue to decrease. the incidence of h ... | 2017 | 28052618 |
| effects of interleukin-4 and interleukin-12b gene polymorphisms on hepatitis b virus vaccination. | approximately 10% of individuals do not respond to hepatitis b virus (hbv) vaccination, i.e. non-responders (nrs). we aimed to investigate the association of interleukin (il)-4 and il-12b gene polymorphisms with responsiveness to the hbv vaccine in korean infants. among 300 healthy infants (9-12 month), snps for the il-4 gene (rs2243250, rs2070874, and rs2227284) and for the il-12b gene (rs3213094 and rs17860508) were compared between subgroups in terms of the response to hbv vaccination. the pe ... | 2017 | 28051794 |
| association between hepatitis b virus and chronic kidney disease: a systematic review and meta-analysis. | background. hepatitis b virus infection and chronic kidney disease are prevalent and remain a major public health problem worldwide. it remains unclear how infection with hepatitis b virus impacts on the development and progression of chronic kidney disease. | 2017 | 28051791 |
| impact of viral etiology on postoperative de novo recurrence after hepatectomy for hepatocellular carcinoma in cirrhotic patients. | liver cirrhosis (lc) and hepatocellular carcinoma (hcc) are associated with viral hepatitis, especially hepatitis b virus (hbv) and hepatitis c virus (hcv). whether differences exist in postoperative de novo carcinogenesis from established cirrhosis according to viral etiology remains unclear. | 2017 | 28050767 |
| do recommendations by healthcare providers, family-members, friends, and individual self-efficacy increase uptake of hepatitis b screening? results of a population-based study of asian americans. | hepatitis b virus (hbv) infection disproportionately affects asian americans but hbv screening rates among asian american are substantially low. this study examines the impact of multiple recommendations and self-efficacy on hbv screening uptake among asian americans. | 2017 | 28058203 |
| late reactivation of hepatitis b virus after chemotherapies for hematological malignancies: a case report and review of the literature. | reactivation of hepatitis b virus (hbv) is a serious complication of immunosuppressive therapy and cytotoxic chemotherapy. the optimal duration of hbv-dna monitoring for at-risk patients depends on the clinical features of reactivation, especially the range of potency from therapies to reactivation. we present a case of very late reactivation after chemotherapy for lymphoma and review previous reports of late reactivation cases. we also underscore the significance of developing an indicator for ... | 2017 | 28049989 |
| investigation of a novel hepatitis b virus surface antigen (hbsag) escape mutant affecting immunogenicity. | mutation in the hepatitis b virus surface antigen (hbsag) may affect the efficiency of diagnostic immunoassays or success of vaccinations using hbsag. thus, antigenicity and immunogenicity analyses of the mutated hbsag are necessary to develop novel diagnostic tools and efficient vaccinations. here, the in vitro antigenicity of three wild-type hbsag open reading frames (orfs) (adr4, w1s [subtype adr] and w3s [subtype adr]) isolated from clinically infected patients and nineteen synthesized singl ... | 2017 | 28045894 |
| impact of viral status on survival in patients receiving sorafenib for advanced hepatocellular cancer: a meta-analysis of randomized phase iii trials. | purpose following the sorafenib hepatocellular carcinoma assessment randomized protocol (sharp) trial, sorafenib has become the standard of care for patients with advanced unresectable hepatocellular carcinoma, but the relation between survival advantage and disease etiology remains unclear. to address this, we undertook an individual patient data meta-analysis of three large prospective randomized trials in which sorafenib was the control arm. methods of a total of 3,256 patients, 1,643 (50%) w ... | 2017 | 28045619 |
| transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis b virus replication. | hepatitis b virus (hbv) replication in hepatocytes is restricted by the host innate immune system and related intracellular signaling pathways. transforming growth factor β-activated kinase 1 (tak1) is a key mediator of toll-like receptors and pro-inflammatory cytokine signaling pathways. here, we report that silencing or inhibition of endogenous tak1 in hepatoma cell lines leads to an upregulation of hbv replication, transcription, and antigen expression. in contrast, overexpression of tak1 sig ... | 2017 | 28045080 |
| identification of amino acids in antigen-binding site of class ii hla proteins independently associated with hepatitis b vaccine response. | genetic factors in class ii human leukocyte antigen (hla) have been reported to be associated with inter-individual variation in hepatitis b virus (hbv) vaccine response. however, the mechanism underlying the associations remains elusive. in particular, the broad linkage disequilibrium in hla region complicates the localization of the independent effects of genetic variants. thus, the present study aimed to identify the most probable causal variations in class ii hla loci involved in the immune ... | 2017 | 28043736 |
| occurrence of needlestick and injuries among health-care workers of a tertiary care teaching hospital in north india. | occupational hazards such as accidental exposure to sharp, cuts, and splashes are common among health-care workers (hcws). | 2017 | 28042212 |
| role of interleukin-23 in monocyte-derived dendritic cells of hbv-related acute-on-chronic liver failure and its correlation with the severity of liver damage. | the role of interleukin-23 (il-23) in monocyte-derived dendritic cells (modcs) from hepatitis b virus-related acute-on-chronic liver failure (hbv-aclf) patients remains unclear. the aim of this study was to observe the correlation between the activation of the il-23 signaling pathway and the prognosis of hbv-aclf patients. | 2017 | 28041935 |
| the hla-g 14-base pair deletion allele and the deletion/deletion genotype are associated with persistent hbe antigenemia in chronic hepatis b infection. | hla-g has well-recognized immunomodulatory properties, and this molecule is frequently expressed in the livers of hepatitis b virus (hbv)-infected patients. because the hla-g 14 bp-insertion/deletion polymorphism (rs371194629) has been associated with the magnitude of hla-g expression, we evaluated this polymorphism in the recognized evolutionary forms of chronic hbv infection. | 2017 | 28041834 |
| s-1 plus sorafenib for the treatment of advanced hepatocellular carcinoma. | to assess the efficacy and safety of s-1 plus sorafenib for the treatment of advanced hepatocellular carcinoma (hcc). | 2017 | 28039697 |
| hepatitis b virus infection and decreased risk of nonalcoholic fatty liver disease: a cohort study. | the presence of an association between chronic hepatitis b virus (hbv) infection and fatty liver is controversial. we examined the association between hbv infection and the development of nonalcoholic fatty liver disease (nafld). we conducted a cohort study of 83,339 participants without nafld at baseline who underwent serologic testing for hepatitis b surface antigen (hbsag) between 2002 and 2006 and were followed annually or biennially until december 2014. nafld was defined as the presence of ... | 2017 | 28035771 |
| rapid alanine aminotransferase normalization with entecavir and hepatocellular carcinoma in hepatitis b virus-associated cirrhosis. | sustained abnormal serum alanine aminotransferase (alt) levels can increase the risk of hepatocellular carcinoma (hcc) in patients with chronic hepatitis b. | 2017 | 28035553 |
| variations in il-1r1 gene influence risk for hepatitis b virus infection of children in a han chinese population. | host genetic factors play an important role in the pathogenesis of hepatitis b virus (hbv) infection. however, the role of interleukin1receptor, type i (il-1r1) gene in hbv infection and breakthrough infection in children remains unclear. the aim of this study was to investigate the association between snps in il-1 family and hbv infection and breakthrough infection in children. | 2017 | 28027994 |
| hbv inhibits lps-induced nlrp3 inflammasome activation and il-1β production via suppressing the nf-κb pathway and ros production. | hepatitis b virus (hbv) has developed strategies to evade immune responses. however, the mechanisms involved remain unclear. the nlrp3 inflammasome plays crucial roles in antiviral host defense and its downstream factor il-1β has been shown to inhibit hbv infection in vivo. this study aims to assess whether hbv can affect the nlrp3 inflammasome signaling pathways and shed light on the underlying mechanisms hbv utilizes to evade host innate immune responses. | 2017 | 28027970 |
| longterm prognosis of combined hepatocellular carcinoma-cholangiocarcinoma following liver transplantation and resection. | combined hepatocellular carcinoma-cholangiocarcinoma (chcc-cc) is a rare disease. we investigated the clinicopathological features of chcc-cc and compared the longterm outcomes following liver transplantation (lt) and hepatic resection (hr). we identified 32 lt patients with chcc-cc through an institutional database search. the hr control group (n = 100) was selected through propensity score-matching. the incidence of chcc-cc among all adult lt patients was 1.0%. mean patient age was 53.4 ± 6.7 ... | 2017 | 28027599 |
| hepatitis b reactivation in hbsag-negative/hbcab-positive patients receiving immunosuppressive therapy for glomerulonephritis: a retrospective analysis. | the aim of this study is to investigate the prevalence and risk factors for hepatitis b virus (hbv) reactivation in hbsag-negative/hbcab-positive patients receiving immunosuppressive therapy for glomerulonephritis. | 2017 | 28032257 |
| t cells infiltrating diseased liver express ligands for the nkg2d stress surveillance system. | nk cells, which are highly enriched in the liver, are potent regulators of antiviral t cells and immunopathology in persistent viral infection. we investigated the role of the nkg2d axis in t cell/nk cell interactions in hepatitis b. activated and hepatitis b virus (hbv)-specific t cells, particularly the cd4 fraction, expressed nkg2d ligands (nkg2dl), which were not found on t cells from healthy controls (p < 0.001). nkg2dl-expressing t cells were strikingly enriched within hbv-infected livers ... | 2017 | 28031333 |
| subtypes and risk behaviors among incident hiv cases in the bangkok men who have sex with men cohort study, thailand, 2006-2014. | hiv-1 incidence and prevalence remain high among men who have sex with men (msm), and transgender women (tgw), in thailand. to examine the link between epidemiologic factors and hiv-1 subtype transmission among thai msm, we compared covariates of infection with hiv crf01_ae and other hiv strains among participants in the bangkok msm cohort study (bmcs). the bmcs was an observational cohort study of thai msm and tgw with up to 60 months of follow-up at 4 monthly intervals. participants underwent ... | 2017 | 28019101 |
| analysis of the prevalence of drug-resistant hepatitis b virus in patients with antiviral therapy failure in a chinese tertiary referral liver centre (2010-2014). | to study the prevalence of drug-resistant hbv in patients with therapy failure in a chinese tertiary referral liver centre. | 2017 | 28017671 |
| risk factors related to the failure of prevention of hepatitis b virus mother-to-child transmission in yunnan, china. | to investigate the relationship between the failure of prevention of hepatitis b virus mother-to-child transmission and hbv serological pattern, viral load as well as hbv genotypes. | 2017 | 28017429 |
| reduction in liver transplant wait-listing in the era of direct-acting antiviral therapy. | direct-acting antiviral (daa) therapy, recently approved for patients with decompensated cirrhosis (dc) secondary to hepatitis c virus (hcv), is associated with improved hepatic function. we analyzed trends in liver transplant (lt) wait-listing (wl) to explore potential impact of effective medical therapy on wl registration. this is a cohort study using the scientific registry of transplant recipients database from 2003 to 2015. a total of 47,591 adults wait-listed for lt from hcv, hepatitis b v ... | 2017 | 28012259 |
| the history and challenges of blood donor screening in china. | since the establishment of people's republic of china in 1949, the chinese government has encountered several catastrophes related to transfusion transmitted diseases. the government's increasing attention to blood safety has prompted the initiation of a series of policies and measures that have enhanced the level of safety for the blood supply and met the basic clinical demands of blood for 1.3 billion people in the country. blood donation screening strategies in china predominantly comprise do ... | 2017 | 28012709 |
| predicting the clinical outcome of icsi by sperm head vacuole examination. | to assess whether high magnification sperm head vacuole examination (shve) and/or standard sperm morphology assessment can predict icsi outcomes in terms of fertilization, embryo quality, and delivery rates, a prospective observational bicentric study was conducted in two publicly funded assisted reproductive technology (art) units in france between january and july of 2012. a total of 111 icsi cycles for exclusively male infertility factors were included. a spearman's correlation test was perfo ... | 2017 | 28010131 |
| preoperatively staging liver fibrosis using noninvasive method in hepatitis b virus-infected hepatocellular carcinoma patients. | advanced liver fibrosis can result in serious complications (even patient's death) after partial hepatectomy. preoperatively percutaneous liver biopsy is an invasive and expensive method to assess liver fibrosis. we aim to establish a noninvasive model, on the basis of preoperative biomarkers, to predict liver fibrosis in hepatocellular carcinoma (hcc) patients with hepatitis b virus (hbv) infection. | 2017 | 28008144 |
| characteristics and course of chronic hepatitis b e antigen-negative infection. | to describe the epidemiological, analytical and histological characteristics and clinical course of hepatitis b virus (hbv) carriers with negative hbe antigen. | 2017 | 28007350 |
| recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis b virus infection. | there are ~350 million chronic carriers of hepatitis b (hbv). while a prophylactic vaccine and drug regimens to suppress viremia are available, chronic hbv infection is rarely cured. hbv's limited host tropism leads to a scarcity of susceptible small animal models and is a hurdle to developing curative therapies. mice that support engraftment with human hepatoctyes have traditionally been generated through crosses of murine liver injury models to immunodeficient backgrounds. here, we describe th ... | 2017 | 28006671 |
| response to tenofovir among lamivudine-experienced hepatitis b and hiv-coinfected adolescents. | we determined hepatitis b virus (hbv) suppression rates among 18 lamivudine (3tc)-experienced hbv-human immunodeficiency virus-coinfected adolescents after treatment with tenofovir disoproxil fumurate (tdf). at tdf initiation, their median age was 17.6 years, and duration of 3tc exposure was 7.3 years. eleven patients (61%) achieved hbv dna <60 iu/ml after 48 weeks on tdf and 3tc which was similar to adult studies, although hepatitis b surface antigen loss or hepatitis b envelope antigen serocon ... | 2017 | 28005687 |
| clinical significance of dynamics of programmed death ligand-1 expression on circulating cd14(+) monocytes and cd19(+) b cells with the progression of hepatitis b virus infection. | programmed death-1 (pd-1) expression has been revealed to be upregulated on t cells and contributes to t cell exhaustion in patients with hepatitis b virus (hbv) infection. in this study, we investigated the dynamic expression of programmed death ligand-1 (pd-l1), the ligand of pd-1, on circulating cd14(+) monocytes and cd19(+) b cells of hbv-infected patients at the stages of chronic hbv (chb) infection, liver cirrhosis (lc), and hepatocellular carcinoma (hcc), respectively. the results showed ... | 2017 | 28005469 |
| a follow-up study on the renal protective efficacy of telbivudine for hepatitis b virus-infected taiwanese patients after living donor liver transplant. | preservation of renal function is an important issue after living donor liver transplant. we aimed to examine the renal protective efficacy of telbivudine in hepatitis b virus-infected patients after living donor liver transplant. | 2017 | 28004999 |
| seroprevalence and diagnosis of hiv, hbv, hcv and syphilis infections among blood donors. | blood transfusion is one of the most important therapeutic options of life-saving intervention for recipients who are in diseased or non-diseased conditions with severe blood loss. however, it is associated with certain risks which can lead to adverse consequences that may cause acute or delayed complications and bring the risk of transfusion-transmissible infections including hiv, hepatitis b & c and syphilis. so, there might be a fatal risk instead of life saving. this paper aims to provide a ... | 2017 | 28009328 |
| assessment of semi-automated nucleic acid testing programme in a regional blood transfusion centre. | detection of human immunodeficiency virus type-1 (hiv-1), hepatitis-c (hcv) and hepatitis-b virus (hbv) in the blood donors is crucial. an efficient form of detection is nucleic acid testing (nat) in blood screening. we assessed the suitability of commercial nat testing in a developing country, focusing on the altona realstar assay and the method of sacace biotechnologies. | 2017 | 27996693 |