Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| pegivirus infection in domestic pigs, germany. | 2016 | 27314228 | |
| using 300 pretreatment shock waves in a voltage ramping protocol can significantly reduce tissue injury during extracorporeal shock wave lithotripsy. | pretreating a pig kidney with 500 low-energy shock waves (sws) before delivering a clinical dose of sws (2000 sws, 24 kv, 120 sws/min) has been shown to significantly reduce the size of the hemorrhagic lesion produced in that treated kidney, compared with a protocol without pretreatment. however, since the time available for patient care is limited, we wanted to determine if fewer pretreatment sws could be used in this protocol. as such, we tested if pretreating with 300 sws can initiate the sam ... | 2016 | 27307070 |
| search for a reliable model for bisphosphonate-related osteonecrosis of the jaw: establishment of a model in pigs and description of its histomorphometric characteristics. | the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (bronj) remains unknown, and the development of a reliable experimental model would help to improve our understanding of it. we used 12 domestic pigs of which 6 made up the experimental group and were treated with zoledronate 4mg intravenously weekly for 5 weeks, while the control group (n=6) were given no drugs. on day 60 the right second maxillary and mandibular third molars were extracted. thirty days later 3 animals in each ... | 2016 | 27282083 |
| microwave versus saline-linked radiofrequency (aquamantys) assisted liver resection in a porcine liver resection model. a safety and feasibility pilot study. | the aim of this study was to compare the feasibility, efficacy and safety of microwave ablation and saline-linked radiofrequency (aquamantys) in liver resection. | 2016 | 27273952 |
| targeted gene knockin in porcine somatic cells using crispr/cas ribonucleoproteins. | the pig is an ideal large animal model for genetic engineering applications. a relatively short gestation interval and large litter size makes the pig a conducive model for generating and propagating genetic modifications. the domestic pig also shares close similarity in anatomy, physiology, size, and life expectancy, making it an ideal animal for modeling human diseases. often, however, the technical difficulties in generating desired genetic modifications such as targeted knockin of short stre ... | 2016 | 27240344 |
| endoscopic ultrasound guided injection of iron oxide magnetic nanoparticles for liver and pancreas: a feasibility study in pigs. | pancreatic cancer and hepatocellular carcinoma are two of the most aggressive types of cancer with limited therapeutic options in stages of advanced disease. our objective is to assess the safety and feasibility of injecting iron oxide nanoparticles (ions) via endoscopic ultrasound (eus)-guidance, both systemically and locally in the liver and pancreas in order to study new potential therapies for liver and pancreatic tumors. | 2016 | 27239648 |
| omental flow-through flap: experimental hemodynamic study. | the omental flow-through flap (oftf) is based on the use of an anatomic unit composed of the right gastro-omental artery (bypass) with its omental branch or branches supplying the greater omentum (flap). the greater omentum flap is known for its capacity of resistance to infection, for its use in the treatment of ischemic lesions and as a high-flow tissue. several hypotheses regarding the hemodynamic behavior of a distal bypass with a flap were discussed in the literature. we made the assumption ... | 2016 | 27238991 |
| reperfusion injury protection during basic life support improves circulation and survival outcomes in a porcine model of prolonged cardiac arrest. | ischemic postconditioning (pc) using three intentional pauses at the start of cardiopulmonary resuscitation (cpr) improves outcomes after cardiac arrest in pigs when epinephrine (epi) is used before defibrillation. we hypothesized pc, performed during basic life support (bls) in the absence of epinephrine, would reduce reperfusion injury and enhance 24h functional recovery. | 2016 | 27211835 |
| peri-implant defect regeneration in the diabetic pig: a preclinical study. | the study aims to establish a peri-implant dehiscence-type bone defect in a diabetic animal model of human bone repair and to quantify the influence of diabetes on peri-implant bone regeneration. | 2016 | 27209350 |
| functional plasticity of adipose-derived stromal cells during development of obesity. | obesity is a major risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer. expansion of the adipose mass requires adipocyte precursor cells that originate from multipotent adipose-derived stromal cells (ascs), which in turn also participate in repair activities. asc function might decline in a disease milieu, but it remains unclear whether asc function varies during the development of obesity. we tested the hypothesis that microenvironmental inflamm ... | 2016 | 27177576 |
| influence of chest compressions on circulation during the peri-cardiac arrest period in porcine models. | starting chest compressions immediately after a defibrillation shock might be harmful, if the victim already had a return of spontaneous circulation (rosc) and yet was still being subjected to external compressions at the same time. the objective of this study was to study the influence of chest compressions on circulation during the peri-cardiac arrest period. | 2016 | 27168071 |
| technical note: evaluation of a 160-mm/256-row ct scanner for whole-heart quantitative myocardial perfusion imaging. | the authors investigated the performance of a recently introduced 160-mm/256-row ct system for low dose quantitative myocardial perfusion (mp) imaging of the whole heart. this platform is equipped with a gantry capable of rotating at 280 ms per full cycle, a second generation of adaptive statistical iterative reconstruction (asir-v) to correct for image noise arising from low tube voltage potential/tube current dynamic scanning, and image reconstruction algorithms to tackle beam-hardening, cone- ... | 2016 | 27487900 |
| a naturally hypersensitive glucocorticoid receptor elicits a compensatory reduction of hypothalamus-pituitary-adrenal axis activity early in ontogeny. | we comprehensively characterized the effects of a unique natural gain-of-function mutation in the glucocorticoid receptor (gr), grala610val, in domestic pigs to expand current knowledge of the phenotypic consequences of gr hypersensitivity. cortisol levels were consistently reduced in one-week-old piglets, at weaning and in peripubertal age, probably due to a reduced adrenal capacity to produce glucocorticoids (gc), which was indicated by an adrenocortical thinning in grala610val carriers. adren ... | 2016 | 27440422 |
| romanian wild boars and mangalitza pigs have a european ancestry and harbour genetic signatures compatible with past population bottlenecks. | we aimed to analyse the genetic diversity of romanian wild boars and to compare it with that from other wild boar and pig populations from europe and asia. partial sequencing of the mitochondrial encoded cytochrome b (mt-cyb) gene from 36 romanian wild boars and 36 domestic pigs (mangalitza, bazna and vietnamese breeds) showed that the diversity of romanian wild boars and mangalitza pigs is fairly reduced, and that most of the members of these two populations share a common mt-cyb haplotype. bes ... | 2016 | 27418428 |
| an experimental comparative study on classic tube thoracostomy and thoracostomy with a newly designed thorax drainage catheter. | the collection of fluids, blood, pus, or air in the pleural cavity is a pathological condition requiring pleural drainage. a newly designed thorax drainage catheter in the prototype phase was used in this experimental study to test its efficacy. | 2016 | 27511340 |
| dynamic variables fail to predict fluid responsiveness in an animal model with pericardial effusion. | the reliability of dynamic and volumetric variables of fluid responsiveness in the presence of pericardial effusion is still elusive. the aim of the present study was to investigate their predictive power in a porcine model with hemodynamic relevant pericardial effusion. | 2016 | 27499343 |
| simulating the epidemiological and economic effects of an african swine fever epidemic in industrialized swine populations. | african swine fever (asf) is a notifiable infectious disease with a considerable impact on animal health and is currently one of the most important emerging diseases of domestic pigs. asf was introduced into georgia in 2007 and subsequently spread to the russian federation and several eastern european countries. consequently, there is a non-negligible risk of asf spread towards western europe. therefore it is important to develop tools to improve our understanding of the spread and control of as ... | 2016 | 27599924 |
| prevalence and consequences of chromosomal abnormalities in canadian commercial swine herds. | structural chromosome abnormalities are well known as factors that reduce fertility rate in domestic pigs. according to large-scale national cytogenetic screening programs that are implemented in france, it is estimated that new chromosome abnormalities occur at a rate of 0.5 % in fertility-unproven boars. | 2016 | 27620715 |
| hyperpolarized13c,15n2-urea mri for assessment of the urea gradient in the porcine kidney. | a decline in cortico-medullary osmolality gradient of the kidney may serve as an early indicator of pathological disruption of the tubular reabsorption process. the purpose of this study was to investigate the feasibility of hyperpolarized13c,15n2-urea mri as a biomarker of renal function in healthy porcine kidneys resembling the human physiology. | 2016 | 27670826 |
| comparison of microchip transponder and noncontact infrared thermometry with rectal thermometry in domestic swine (sus scrofa domestica). | during disease outbreaks, core temperature is a useful health metric in swine, due to the presence of pyrexia especially during the acute phase of infection. despite technologic advances in other facets of swine production and health management, rectal thermometry continues to be the 'gold standard' for measuring core body temperature. however, for various reasons, collecting rectal temperatures can be difficult and unsafe depending on the housing modality. in addition, the delay between inserti ... | 2016 | 27657715 |
| the effect of long-term amiodarone administration on myocardial fibrosis and evolution of left ventricular remodeling in a porcine model of ischemic cardiomyopathy. | amiodarone is effective in suppressing arrhythmias in heart failure patients. we investigated the effect of long-term amiodarone administration on myocardial fibrosis and left ventricular (lv) remodeling in a porcine model of ischemic cardiomyopathy. eighteen infarcted farm pigs were randomized to receive long-term amiodarone administration for 3 months (n = 9) or conventional follow-up (n = 9). evolution of lv remodeling over 3 months post-myocardial infarction was examined at tissue level (myo ... | 2016 | 27652141 |
| first record of the larval endoparasitoid tachinaephagus zealandicus (hymenoptera: encyrtidae) from fly hosts developing on burnt remains and in pennsylvania. | adults of the gregarious larval endoparasitoid tachinaephagus zealandicus ashmead (hymenoptera: encyrtidae) were collected from two species of carrion-inhabiting flies, phormia regina meigen (diptera: calliphoridae) and hydrotaea aenescens wiedemann (muscidae), associated with the burnt remains of a domesticated pig, sus scrofa l. (artiodactyla: suidae), during late summer in south central pennsylvania. this represents the first reported occurrence of the wasp in the state and only the second in ... | 2016 | 26875188 |
| comparable vascular response of a new generation sirolimus eluting stents when compared to fluoropolymer everolimus eluting stents in the porcine coronary restenosis model. | novel sirolimus eluting stents (ses) have shown non-inferior clinical outcomes when compared to everolimus eluting stents (ees), however only limited preclinical data have been published. therefore, we evaluate vascular response of a new generation biodegradable polymer ses (bp-ses: alex plus, balton) and fluoropolymer ees (ees: xience pro, abbott) in the porcine coronary restenosis model. | 2016 | 27976797 |
| social support modulates stress-related gene expression in various brain regions of piglets. | the presence of an affiliative conspecific may alleviate an individual's stress response in threatening conditions. however, the mechanisms and neural circuitry underlying the process of social buffering have not yet been elucidated. using the domestic pig as an animal model, we examined the effect of a 4-h maternal and littermate deprivation on stress hormones and on mrna expression of the glucocorticoid receptor (gr), mineralocorticoid receptor (mr), 11ß-hydroxysteroid dehydrogenase (11ß-hsd) ... | 2016 | 27965550 |
| control of african swine fever epidemics in industrialized swine populations. | african swine fever (asf) is a notifiable infectious disease with a high impact on swine health. the disease is endemic in certain regions in the baltic countries and has spread to poland constituting a risk of asf spread toward western europe. therefore, as part of contingency planning, it is important to explore strategies that can effectively control an epidemic of asf. in this study, the epidemiological and economic effects of strategies to control the spread of asf between domestic swine he ... | 2016 | 27938676 |
| somatic cell nuclear transfer followed by cripsr/cas9 microinjection results in highly efficient genome editing in cloned pigs. | the domestic pig is an ideal "dual purpose" animal model for agricultural and biomedical research. with the availability of genome editing tools such as clustered regularly interspaced short palindromic repeat (crispr) and associated nuclease cas9 (crispr/cas9), it is now possible to perform site-specific alterations with relative ease, and will likely help realize the potential of this valuable model. in this article, we investigated for the first time a combination of somatic cell nuclear tran ... | 2016 | 27918485 |
| frequency of vascular inflammation and impact on neointimal proliferation of drug eluting stents in porcine coronary arteries. | we aimed to describe the frequency of vascular inflammatory reactions with second generation drug eluting stents (des) compared to first generation des, and analyze the impact on inflammation and neointimal proliferation in a porcine coronary model. | 2016 | 27713606 |
| minimally invasive beat-by-beat monitoring of cardiac power in normal hearts and during acute ventricular dysfunction. | cardiac power, the product of aortic flow and blood pressure, appears to be a fundamental cardiovascular parameter. the simplified version named cardiac power output (cpo), calculated as the product of cardiac output (co) in l/min and mean arterial pressure (map) in mmhg divided by 451, has shown great ability to predict outcome in a broad spectrum of cardiac disease. beat-by-beat evaluation of cardiac power (pwr) therefore appears to be a possibly valuable addition when monitoring circulatory u ... | 2016 | 27702881 |
| flexible growing rods: a biomechanical pilot study of polymer rod constructs in the stability of skeletally immature spines. | surgical treatments for early onset scoliosis (eos) correct curvatures and improve respiratory function but involve many complications. a distractible, or 'growing rod,' implant construct that is more flexible than current metal rod systems may sufficiently correct curves in small children and reduce complications due to biomechanical factors. the purpose of this pilot study was to determine ranges of motion (rom) after implantation of simulated growing rod constructs with a range of clinically ... | 2016 | 27689140 |
| a usability comparison of laser suction handpieces for percutaneous nephrolithotomy. | the holmium laser has revolutionized the practice of minimally invasive endoscopy for kidney stones. recently, a novel, rigid handpiece for use in percutaneous nephrolithotomy (pcnl) that couples the holmium laser with suction has been developed. to date, limited data exist regarding the usability and ergonomics of such treatment systems. we thus sought to compare surgeon-rated usability with three different suction laser handpieces in a porcine model. | 2016 | 27758119 |
| biological effect on restenosis and vascular healing of encapsulated paclitaxel nanocrystals delivered via coated balloon technology in the familial hypercholesterolaemic swine model of in-stent restenosis. | the aim of this study was to evaluate the biological efficacy of a novel lower-dose (2.5 µg/mm2) encapsulated paclitaxel nanocrystal-coated balloon (nano-pcb) in the familial hypercholesterolaemic swine (fhs) model of iliofemoral in-stent restenosis. | 2016 | 27753601 |
| novel y-chromosome short tandem repeats in sus scrofa and their variation in european wild boar and domestic pig populations. | y-chromosome markers are important tools for studying male-specific gene flow within and between populations, hybridization patterns and kinship. however, their use in non-human mammals is often hampered by the lack of y-specific polymorphic markers. we identified new male-specific short tandem repeats (strs) in sus scrofa using the available genome sequence. we selected four polymorphic loci (5-10 alleles per locus), falling in one duplicated and two single-copy regions. a total of 32 haplotype ... | 2016 | 27558303 |
| genomic analysis reveals selection in chinese native black pig. | identification of genomic signatures that help reveal mechanisms underlying desirable traits in domesticated pigs is of significant biological, agricultural and medical importance. to identify the genomic footprints left by selection during domestication of the enshi black pig, a typical native and meat-lard breed in china, we generated about 72-fold coverage of the pig genome using pools of genomic dna representing three different populations of enshi black pigs from three different locations. ... | 2016 | 27808243 |
| in-depth proteomic analysis of the porcine retina by use of a four step differential extraction bottom up lc ms platform. | the eye of the house swine (sus scrofa domestica linnaeus, 1758) represents a promising model for the study of human eye diseases encircling neurodegenerative retina disorders that go along with proteomic changes. to provide an in-depth view into the "normal" (untreated & healthy) porcine retina proteome as an important reference, a proteomic strategy has been developed encircling stepwise/differential extraction, lc ms and peptide de novo sequencing. accordingly, pooled porcine retina homogenat ... | 2016 | 27796761 |
| evaluation of dry feeding and liquid feeding to lactating sows under high temperature environment. | liquid feeding system has been introduced to domestic swine farms, but negative cognition about liquid feeding system has been remained for feed waste decay related with poor management and microbial contamination. for these reasons, this study was conducted to evaluate the effects of feeding method in lactating sows. | 2016 | 27795834 |
| low-level laser therapy to the bone marrow reduces scarring and improves heart function post-acute myocardial infarction in the pig. | cell therapy for myocardial repair is one of the most intensely investigated strategies for treating acute myocardial infarction (mi). the aim of the present study was to determine whether low-level laser therapy (lllt) application to stem cells in the bone marrow (bm) could affect the infarcted porcine heart and reduce scarring following mi. | 2016 | 26741110 |
| establishment and characterization of porcine focal cerebral ischemic model induced by endothelin-1. | due to well-developed circle of willis in pigs, it is technically challenging to make persistent focal ischemic stroke based on occlusion of cerebral arteries. endothelin-1 could cause a focal lesion by forcing transient but strong vasoconstriction in the circumscribed injected area. its use in porcine stroke model has drawn attention lately. however, all the porcine endothelin-1 induced models were euthanized soon after surgery. whether the brain lesion is persistent, and whether they could cau ... | 2016 | 27773792 |
| diaphragmatic hernia of the stomach with gastric rupture in a domestic pig. | a 5.5-mo-old castrated, male red duroc pig presented acutely with depression and abdominal pain 9 d after an altercation with another pig. a ct examination indicated right pneumothorax and herniation of the stomach into the thoracic cavity. due to a poor prognosis, the pig was euthanized. a necropsy and gross examination revealed a tear of the diaphragmatic muscle in the region of the esophageal hiatus through which the stomach was displaced into the right side of the thoracic cavity. in additio ... | 2016 | 27780007 |
| cardioprotective effects of intracoronary administration of 4-chlorodiazepam in small and large animal models of ischemia-reperfusion. | the translocator protein (tspo) of the mitochondrial membrane has been recognized as a potential therapeutic target for mitigation of myocardial ischemia-reperfusion injury. administration of 4-chlorodiazepam (4-cld), a tspo ligand, has been shown to confer acute cardioprotective effects in small animals; however, long-term studies and studies in clinically-relevant large animal models are lacking. in the present study we investigated a potential cardioprotective effect of intracoronary administ ... | 2016 | 27643472 |
| reproductive ratio for the local spread of african swine fever in wild boars in the russian federation. | african swine fever (asf) has caused the swine industry of the russian federation substantial economic losses over the last 7 years, and the disease spread from there to a number of neighbouring countries. wild boar has been involved in the spread of the disease both at local and at transboundary levels. understanding asf dynamics in wild boars is prerequisite to preventing the spread and to designing and applying effective surveillance and control plans. the reproductive ratio (r0) is an epidem ... | 2016 | 25704269 |
| comparison of bipolar radiofrequency ablation zones in an in vivo porcine model: correlation of histology and gross pathological findings. | continuing research ex vivo and in vivo with animal models is performed to advance the oncological safety of radiofrequency ablation (rfa) of liver tumors. in these experiments, frequently imaging modalities (e.g. mri or ct) or macro-morphological measurements are used to determine the full extent of the different ablation zones inside of rfa lesions. however, no systematic study has been performed so far, which verified the accuracy of the macro-morphological findings. therefore, the present st ... | 2016 | 27858704 |
| pilot in vivo study of an absorbable polydioxanone vena cava filter. | the objectives of this study were to evaluate tensile strength retention of polydioxanone as a function of time in a swine venous system and to assess the feasibility of an absorbable inferior vena cava (ivc) filter made from polydioxanone in a pilot swine study. | 2015 | 26992619 |
| heart rate variability in porcine progressive peritonitis-induced sepsis. | accumulating evidence suggests that heart rate variability (hrv) alterations could serve as an indicator of sepsis progression and outcome, however, the relationships of hrv and major pathophysiological processes of sepsis remain unclear. therefore, in this experimental study hrv was investigated in a clinically relevant long-term porcine model of severe sepsis/septic shock. hrv was analyzed by several methods and the parameters were correlated with pathophysiological processes of sepsis. in 16 ... | 2015 | 26779039 |
| establishment of a new pull-out strength testing method to quantify early osseointegration-an experimental pilot study. | the animal study aims to evaluate a new experimental model for measuring sole the influence of the surface characteristics independent from implant macro-design on the level of osseointegration by registering the pull-out strength needed for removal of experimental devices with different surfaces from artificial defects. | 2015 | 26616405 |
| shifts in soil biodiversity-a forensic comparison between sus scrofa domesticus and vegetation decomposition. | in a forensic context, microbial-mediated cadaver decomposition and nutrient recycling cannot be overlooked. as a result, forensic ecogenomics research has intensified to gain a better understanding of cadaver/soil ecology interactions as a powerful potential tool for forensic practitioners. for this study, domestic pig (sus scrofa domesticus) (4g) and grass (agrostis/festuca spp) cuttings (4g) were buried (july 2013 to july 2014) in sandy clay loam (80 g) triplicates in sealed microcosms (127 m ... | 2015 | 26654074 |
| an initial investigation into the ecology of culturable aerobic postmortem bacteria. | postmortem microorganisms are increasingly recognized for their potential to serve as physical evidence. yet, we still understand little about the ecology of postmortem microbes, particularly those associated with the skin and larval masses. we conducted an experiment to characterize microbiological and chemical properties of decomposing swine (sus scrofa domesticus) carcasses on the island of oahu, hawaii, usa, during june 2013. bacteria were collected from the head, limb, and larval mass durin ... | 2015 | 26654073 |
| african swine fever: a global view of the current challenge. | african swine fever (asf) is an important contagious haemorrhagic viral disease affecting swine whose notification is mandatory due to its high mortality rates and the great sanitary and socioeconomic impact it has on international trade in animal and swine products. this disease only affects porcine species, both wild and domestic, and produces a variety of clinical signs such as fever and functional disorders of the digestive and respiratory systems. lesions are mainly characterized by congest ... | 2015 | 28405426 |
| volume infusion cooling increases end-tidal carbon dioxide and results in faster and deeper cooling during intra-cardiopulmonary resuscitation hypothermia induction. | intra-arrest hypothermia induction may provide more benefit than inducing hypothermia after return of spontaneous circulation. however, little is understood about the interaction between patient physiology and hypothermia induction technology choice during ongoing chest compressions. | 2015 | 26715581 |
| first detection of sarcoptic mange in free-ranging wild boar (sus scrofa) in switzerland. | in switzerland sarcoptic mange is frequent in free-ranging wild carnivores but until recent years no cases had been recorded in wild ungulates. since 2010, cases have been observed in wild boar in the cantons of solothurn, tessin and thurgau. here, we report the detection of mange-like skin lesions in wild boars by photo-trapping and the post-mortem findings in 6 culled animals presenting different stages of the disease. potential sources of infection include mangy red foxes, outdoor domestic pi ... | 2015 | 26753342 |
| [regularity of agonal respiration after untreated cardiac arrest in a swine model]. | to explore the regularity of incidence of agonal respiration (ar) and agonal respiration frequency rate (arfr) during untreated cardiac arrest (ca) after ventricular fibrillation (vf) in a swine model. | 2015 | 27318343 |
| characterization of a porcine model for associating liver partition and portal vein ligation for a staged hepatectomy. | publications using the alpps (associating liver partition and portal vein ligation for a staged hepatectomy) procedure have demonstrated a future liver remnant growth of 40-160% in only 6-9 days. the present study aimed to develop and describe the first large animal model of alpps that can be used for future studies. | 2015 | 26234167 |
| segmental and age differences in the elastin network, collagen, and smooth muscle phenotype in the tunica media of the porcine aorta. | the porcine aorta is often used in studies on morphology, pathology, transplantation surgery, vascular and endovascular surgery, and biomechanics of the large arteries. using quantitative histology and stereology, we estimated the area fraction of elastin, collagen, alpha-smooth muscle actin, vimentin, and desmin within the tunica media in 123 tissue samples collected from five segments (thoracic ascending aorta; aortic arch; thoracic descending aorta; suprarenal abdominal aorta; and infrarenal ... | 2015 | 26232584 |
| influence of internal fixation systems on radiation therapy for spinal tumor. | in this study, the influence of internal fixation systems on radiation therapy for spinal tumor was investigated in order to derive a theoretical basis for adjustment of radiation dose for patients with spinal tumor and internal fixation. based on a common method of internal fixation after resection of spinal tumor, different models of spinal internal fixation were constructed using the lumbar vertebra of fresh domestic pigs and titanium alloy as the internal fixation system. variations in radia ... | 2015 | 26219011 |
| a novel porcine bocavirus harbors a variant np gene. | porcine bocavirus is classified within the genus bocaparvovirus, family parvoviridae. unlike other parvoviruses, the members of genus bocaparvovirus (bocaparvoviruses) encode an additional open reading frame (np1). many strains of pbovs have been identified in domestic pigs and recognized as a potential emerging pathogen causing respiratory and gastrointestinal disease. | 2015 | 26217547 |
| effect of body position on ventilation distribution during peep titration in a porcine model of acute lung injury using advanced respiratory monitoring and electrical impedance tomography. | lung failure after acute lung injury remains a challenge in different clinical settings. various interventions for restoration of gas exchange have been investigated. recruitment of collapsed alveoli by positive end expiratory pressure (peep) titration and optimization of ventilation-perfusion ratio by prone positioning have been extensively described in animal and clinical trials. this animal study was conducted to investigate the effects of peep and positioning by means of advanced respiratory ... | 2015 | 26215805 |
| safety and efficacy of new sirolimus-eluting stent models in a preclinical study. | initial preclinical studies are required during the process of improving polymers, platforms, and drug-eluting systems for new coronary stent designs. our objective was to analyze the efficacy and safety of new drug-eluting stent models compared with a conventional stent and commercialized drug-eluting stents in an experimental model with healthy porcine coronary arteries. | 2015 | 26206247 |
| topical antibiotic ointment versus silver-containing foam dressing for second-degree burns in swine. | second-degree burns are very common but their management is controversial. these burns may be treated with either topical antimicrobial agents or advanced occlusive dressings; however, there is no established treatment comparator for preclinical studies. this study was designed to determine which of two commonly used comparator therapies (a silver-containing advanced dressing or a topical antibiotic ointment) resulted in faster reepithelialization and less scarring. the hypothesis was that secon ... | 2015 | 26202791 |
| blood collection from the orbital sinus of swine. | swine (sus scrofa domesticus) are increasingly used as animal models in biomedical research. often blood samples from these animals are needed for research protocols, but phlebotomy can be difficult, especially with young swine. this column describes a relatively simple technique for blood collection that can be used specifically with young swine. | 2015 | 26398611 |
| the control of classical swine fever in wild boar. | classical swine fever (csf) is a viral disease with severe economic consequences for domestic pigs. natural hosts for the csf virus (csfv) are members of the family suidae, i.e., eurasian wild boar (sus scrofa) are also susceptible. csf in wild boar poses a serious threat to domestic pigs. csfv is an enveloped rna virus belonging to the pestivirus genus of the flaviviridae family. transmission of the infection is usually by direct contact or by feeding of contaminated meat products. in recent de ... | 2015 | 26594202 |
| changes in saliva biomarkers of stress and immunity in domestic pigs exposed to a psychosocial stressor. | a combination of salivary biomarkers measured at the same time, reflecting the different systems that are involved in the stress mechanism, could be the best tool for its evaluation. in this study, changes in a panel of salivary biomarkers of stress and immunity including chromogranin a (cga), iga, cortisol, testosterone, haptoglobin (hp) and c-reactive protein (crp), were evaluated. a total of 14 (7 control and 7 test) crossbred duroc × (landrace × large white) males of 190 days of age were use ... | 2015 | 26412517 |
| human recombinant activated protein c-coated stent for the prevention of restenosis in porcine coronary arteries. | activated protein c (apc), an endogenous protein, inhibits inflammation and thrombosis and interrupts the coagulation cascade. here, we investigated the effect of human recombinant apc on the development of neointimal hyperplasia in porcine coronary arteries. yukon choice bare metal stents were coated with 2.6 µg apc/mm(2). under general anesthesia, apc-coated and bare stents were implanted in the left anterior descending and circumflex coronary arteries of 10 domestic pigs. during the 4-week fo ... | 2015 | 26411437 |
| transgastric endoscopic gastrojejunostomy using holing followed by interrupted suture technique in a porcine model. | to demonstrate the feasibility and reproducibility of a pure natural orifice transluminal endoscopic surgery (notes) gastrojejunostomy using holing followed by interrupted suture technique using a single endoloop matched with a pair of clips in a non-survival porcine model. | 2015 | 26504508 |
| lungs exposed to 1 hour warm ischemia without heparin before harvesting might be suitable candidates for transplantation. | the limiting factor for lung transplantation is the lack of donor organs. the usage of lungs from donation after cardiac death (dcd) would dramatically increase donor availability. in the present paper we wanted to investigate lungs exposed to 1 h of warm ischemia without heparin followed by flush-perfusion and cold storage compared to lungs harvested from heart beating donors (hbd) using standard harvesting technique. | 2015 | 26500001 |
| intraindividual comparison of image quality using retrospective and prospective respiratory gating for the acquisition of thin sliced four dimensional multidetector ct of the thorax in a porcine model. | to intraindividually compare image quality and anatomical depiction of the lung and mediastinum using retrospective and prospective respiratory gating techniques for the acquisition of 4d-multidetector computed tomography (mdct) of the chest in a porcine model. | 2015 | 26495957 |
| effects of hydrogen sulfide (h2s) on mesenteric perfusion in experimental induced intestinal ischemia in a porcine model. | insufficient mesenteric perfusion is a dramatic complication in critically ill patients. hydrogen sulfide, a newly recognized endogenous gaseous mediator, acts as an intestinal vasoactive agent and seems to protect against mesenteric ischemic damage. we investigated whether sodium hydrogen sulfide, a hydrogen sulfide donor, can improve mesenteric perfusion in an experimental model of pigs, both in physiological and ischemic conditions. | 2015 | 26495269 |
| pulse oximetry: a non-invasive, novel marker for the quality of chest compressions in porcine models of cardiac arrest. | pulse oximetry, which noninvasively detects the blood flow of peripheral tissue, has achieved widespread clinical use. we have noticed that the better the quality of cardiopulmonary resuscitation (cpr), the better the appearance of pulse oximetry plethysmographic waveform (pop). we investigated whether the area under the curve (auc) and/or the amplitude (amp) of pop could be used to monitor the quality of cpr. | 2015 | 26485651 |
| morphological aspects and physical properties of enamel and dentine of sus domesticus: a tooth model in laboratory research. | this study aims to describe and analyze morphological and physical properties of deciduous teeth of sus domesticus. ultrastructural analysis, mineral composition and microhardness of enamel and dentine tissues were performed on 10 skulls of s. domesticus. external anatomic characteristics and the internal anatomy of the teeth were also described. data regarding microhardness and ultrastructural analysis were subjected to statistical tests. for ultrastructural analysis, we used the analysis of va ... | 2015 | 26434756 |
| experimental transmission of african swine fever (asf) low virulent isolate nh/p68 by surviving pigs. | african swine fever (asf) has persisted in eastern europe since 2007, and two endemic zones have been identified in the central and southern parts of the russian federation. moderate- to low-virulent asf virus isolates are known to circulate in endemic asf-affected regions. to improve our knowledge of virus transmission in animals recovered from asf virus infection, an experimental in vivo study was carried out. four domestic pigs were inoculated with the nh/p68 asf virus, previously characteriz ... | 2015 | 26432068 |
| evolution of coronary flow in an experimental slow flow model in swines: angiographic and pathological insights. | pathomechanism of coronary slow flow phenomenon remains largely unclear now. present study observed the pathological and angiographic evolution in a pig model of coronary slow flow. | 2015 | 26539516 |
| developing a kinematic understanding of chest compressions: the impact of depth and release time on blood flow during cardiopulmonary resuscitation. | effective cardiopulmonary resuscitation is a critical component of the pre-hospital treatment of cardiac arrest victims. mechanical chest compression (mcc) devices enable the delivery of mcc waveforms that could not be delivered effectively by hand. while chest compression generated blood flow has been studied for more than 50 years, the relation between sternum kinematics (depth over time) and the resulting blood flow have not been well described. using a five parameter mcc model, we studied th ... | 2015 | 26537881 |
| experimental study of kinematic activity of left ventricular myocardium. | a method of invasive and non-invasive examination of epicardial motion was tested on domestic pigs (n=15). the invasive study employed a contact kinematic sensor of the epicardial wall motion, which determined the amplitude, velocity, and angular parameters of examined epicardial region. a non-invasive assessment of the epicardial kinematics based on echocardiographic 2d velocity vector imaging and ecg recoding used to determine the heart electrical axis. the 4-chamber views were uses to analyze ... | 2015 | 26531214 |
| [uterine neoplasia in two geriatric miniature pet pigs - diagnostics and therapy. two case reports]. | miniature pet pigs are becoming ever more common among the patients of small animal practices. due to an advanced age attained in these animals in comparison with conventional pigs in pork production, miniature pet pigs develop age-related diseases that are infrequently observed in farm pigs, including neoplastic alterations of the uterus. we describe two cases of a uterine adenocarcinoma and a leiomyoma, respectively, in two miniature pet pig sows. options and limits of diagnostic measures (uns ... | 2015 | 26530159 |
| allogenic ipsc-derived rpe cell transplants induce immune response in pigs: a pilot study. | stem cell strategies focused on replacement of rpe cells for the treatment of geographic atrophy are under intense investigation. although the eye has long been considered immune privileged, there is limited information about the immune response to transplanted cells in the subretinal space of large animals. the purpose of this study was to evaluate the survival of allogenic induced pluripotent stem cell-derived rpe cells (ipsc-rpe) delivered to the subretinal space of the pig as well as determi ... | 2015 | 26138532 |
| [18f]fdg accumulation in early coronary atherosclerotic lesions in pigs. | inflammation is an important contributor to atherosclerosis progression. a glucose analogue 18f-fluorodeoxyglucose ([18f]fdg) has been used to detect atherosclerotic inflammation. however, it is not known to what extent [18f]fdg is taken up in different stages of atherosclerosis. we aimed to study the uptake of [18f]fdg to various stages of coronary plaques in a pig model. | 2015 | 26120829 |
| electrophysiological, haemodynamic, and mitochondrial alterations induced by levobupivacaine during myocardial ischemia in a pig model: protection by lipid emulsions? | accidental intravascular or high-dose injection of local anesthetics (la) can result in serious, potentially life-threatening complications. indeed, adequate supportive measures and the administration of lipid emulsions are required in such complications. the study's objectives were threefold: (i) evaluate the myocardial toxicity of levobupivacaine when administered intravenously; (ii) investigate levobupivacaine toxicity on cardiomyocytes mitochondrial functions and cellular structure; (iii) as ... | 2015 | 26118736 |
| poly-d-l-lactic acid membranes for bone regeneration. | to histologically and histomorphometrically evaluate the biocompatibility and the biological properties of perforated and nonperforated poly-d-l-lactic acid (pdlla) resorbable membranes, using a model of calvarial monocortical bone defects in domestic pigs. | 2015 | 26114511 |
| vasopressin infusion with small-volume fluid resuscitation during hemorrhagic shock promotes hemodynamic stability and survival in swine. | current management of hemorrhagic shock (hs) in the battlefield and civilian settings favors small-volume fluid resuscitation before controlling the source of bleeding. we investigated in a swine model of hs the effects of vasopressin infusion along with small-volume fluid resuscitation; with erythropoietin (epo) and hs severity as additional factors. | 2015 | 26107942 |
| the interactive effect of the degradation of cotton clothing and decomposition fluid production associated with decaying remains. | textiles are a commonly encountered source of evidence in forensic cases. in the past, most research has been focused on how textiles affect the decomposition process while little attention has been paid to how the decomposition products interact with the textiles. while some studies have shown that the presence of remains will have an effect on the degradation of clothing associated with a decaying body, very little work has been carried out on the specific mechanisms that prevent or delay text ... | 2015 | 26074165 |
| comparison of ketamine-dexmedetomidine-methadone and tiletamine-zolazepam-methadone combinations for short-term anaesthesia in domestic pigs. | cardiorespiratory effects, quality of induction, depth of anaesthesia and quality of recovery were compared in pigs anaesthetised with 8 mg/kg ketamine, 20 µg/kg dexmedetomidine and 0.2 mg/kg methadone (kdm, n = 18) or 8 mg/kg tiletamine-zolazepam and 0.2 mg/kg methadone (tzm, n = 9). anaesthesia with kdm was partially reversed in nine animals with 0.2 mg/kg atipamezole (kdmat). sedation was observed earlier in the tzm group (47.2 ± 25.3 s) than the kdm group (91.5 ± 37.4 s). sternal and lateral ... | 2015 | 26070949 |
| soil fungal community shift evaluation as a potential cadaver decomposition indicator. | fungi metabolise organic matter in situ and so alter both the bio-/physico-chemical properties and microbial community structure of the ecosystem. in particular, they are responsible reportedly for specific stages of decomposition. therefore, this study aimed to extend previous bacteria-based forensic ecogenomics research by investigating soil fungal community and cadaver decomposition interactions in microcosms with garden soil (20 kg, fresh weight) and domestic pig (sus scrofa domesticus) carc ... | 2015 | 26322496 |
| longitudinal study of the early-life fecal and nasal microbiotas of the domestic pig. | the mammalian microbiota plays a key role in host health and disease susceptibility. however, knowledge of the early-age microbiota of pigs is lacking. the purpose of this study was to use high-throughput next-generation sequencing to characterize the fecal and nasal microbiotas of pigs during early life. | 2015 | 26391877 |
| coronary injury score correlates with proliferating cells and alpha-smooth muscle actin expression in stented porcine coronary arteries. | neointimal formation and cell proliferation resulting into in-stent restenosis is a major pathophysiological event following the deployment of stents in the coronary arteries. in this study, we assessed the degree of injury, based on damage to internal elastic lamina, media, external elastic lamina, and adventitia following the intravascular stenting, and its relationship with the degree of smooth muscle cell proliferation. we examined the smooth muscle cell proliferation and their phenotype at ... | 2015 | 26382957 |
| intermediate veins in swine (sus scrofa domestica) kidney: authors' own anatomical classification. | the use of domestic swine as an experimental animal is increasing steadily. swine organs are the best animal model for urological experiments. the aim of the study was to evaluate the course and size of intermediate veins in a swine kidney. the research results were compared with the results obtained from studies on venous vascularisation of human kidneys. the knowledge of the above-mentioned vessels is important both in human and veterinary medicine and will enable researchers to compare and no ... | 2015 | 26050812 |
| introducer development for coronary sinus access from parasternal mediastinotomy. | right parasternal mediastinotomy with right atriotomy has been used clinically for pacemaker insertion. a similar approach might facilitate access to the coronary sinus for biventricular pacing and other manipulations when more conventional approaches are not feasible. the primary barrier to this is lack of appropriate introducers and techniques. | 2015 | 26181586 |
| experimental study of temperature-sensitive chitosan/β-glycerophosphate embolic material in embolizing the basicranial rete mirabile in swines. | the aim of the present study was to evaluate the feasibility of the non-adhesive temperature-sensitive liquid embolic material, chitosan/β-glycerophosphate (c/gp), in embolizing the basicranial rete mirabile (rem) in a swine model of cerebral arteriovenous malformation (cavm). a total of 24 domestic swines were used as the experimental animals, among which 12 pigs underwent direct embolization of one side of the rem, while the other 12 pigs underwent embolization of the bilateral rem following a ... | 2015 | 26170955 |
| expression of vpac1 receptor at the level of mrna and protein in the porcine female reproductive system. | the presence and distribution of vasoactive intestinal polypeptide (vip) receptor vpac1 was studied in the ovary, oviduct and uterus (uterine horn and cervix) of the domestic pig using methods of molecular biology (rt-pcr and immunoblot) and immunohistochemistry. the expression of vpac1 receptor at mrna level was confirmed with rt-pcr in all the studied parts of the porcine female reproductive system by the presence of 525 bp pcr product and at the level of proteins by the detection of 46 kda pr ... | 2015 | 25928928 |
| fluid dynamics simulation of right ventricular outflow tract oversizing. | repair of the right ventricular outflow tract (rvot) in paediatric cardiac surgery remains challenging due to the high reoperation rate. intimal hyperplasia and consequent arteriosclerosis is one of the most important limitation factors for graft durability. since local shear stress and pressure are predictive elements for intimal hyperplasia and wall degeneration, we sought to determine in an oversized 12-mm rvot model, with computed fluid dynamics simulation, the local haemodynamical factors t ... | 2015 | 25912476 |
| real-time in-vivo imaging of pulmonary capillary perfusion using probe-based confocal laser scanning endomicroscopy in pigs: an interventional laboratory study. | little is known about real-time in-vivo microscopy of pulmonary capillary perfusion because current microscopy requires direct access to lung tissue with surgical intervention such as the thoracic-window technique and open-lung model. | 2015 | 25906262 |
| vegf-c and vegf-c156s in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study. | vegf-c156s, a lymphangiogenesis-specific form of vascular endothelial growth factor c (vegf-c), has been considered as a promising candidate for the experimental pro-lymphangiogenic treatment, as it lacks potential angiogenic effects. as a precursor to future clinical trials, the therapeutic efficacy and blood vascular side effects of vegf-c and vegf-c156s were compared in a large animal model of secondary lymphedema. combination of lymphatic growth factor treatment and autologous lymph node tra ... | 2015 | 26018927 |
| the synergy biodegradable polymer everolimus eluting coronary stent: porcine vascular compatibility and polymer safety study. | synergy is a novel platinum chromium alloy stent that delivers abluminal everolimus from an ultrathin poly-lactide-co-glycide (plga) biodegradable polymer. this study evaluated the in vivo degradation of the polymer coating, everolimus release time course, and vascular compatibility of the synergy stent. | 2015 | 26009986 |
| dose-dependent vascular response following delivery of sirolimus via fast releasing, biodegradable polymer stent matrix: an experimental study in the porcine coronary model of restenosis. | fast releasing, rapamycin-eluting stents, although safe, showed inferior results with regard to inhibition of restenosis. | 2015 | 25985728 |
| mitochondrial dna diversity of feral pigs from karukinka natural park, tierra del fuego island, chile. | control or eradication of exotic species is one of the greatest challenges facing biodiversity and ecosystem conservation. domestic pigs (sus scrofa domestica) were released and became feral in the southern region of chilean tierra del fuego island in the 1900s. currently, they inhabit part of karukinka natural park, an area of global conservation concern. to gain insight into the control of this invasive species, we analyzed genetic variation in the mitochondrial dna control region to determine ... | 2015 | 25966196 |
| the effects of altered maxillary growth on patterns of mandibular rotation in a pig model. | a thorough understanding of influence of maxillary growth on patterns of mandibular rotation during development is important with regard to the treatment of skeletal discrepancies. in the present study, we examined whether experimentally altered maxillary position has a significant influence on patterns of mandibular rotation in a pig model. | 2015 | 25841069 |
| the chimerical genome of isla del coco feral pigs (costa rica), an isolated population since 1793 but with remarkable levels of diversity. | the history of domestic species and of their wild ancestors is not a simple one, and feral processes can clarify key aspects of this history, including the adaptive processes triggered by new environments. here, we provide a comprehensive genomic study of isla del coco (costa rica) feral pigs, a unique population that was allegedly founded by two individuals and has remained isolated since 1793. using snp arrays and genome sequencing, we show that cocos pigs are hybrids between asian and europea ... | 2015 | 25827466 |
| flexible growing rods: a pilot study to determine if polymer rod constructs may provide stability to skeletally immature spines. | surgical treatments for early onset scoliosis (eos), including growing rod constructs, involve many complications. some are due to biomechanical factors. a construct that is more flexible than current instrumentation systems may reduce complications. the purpose of this preliminary study was to determine spine range of motion (rom) after implantation of simulated growing rod constructs with a range of clinically relevant structural properties. the hypothesis was that rom of spines instrumented w ... | 2015 | 25810752 |
| wild boars from sweden, austria, the czech republic and japan possess intact mannose-binding lectin 2 (mbl2) genes. | the two-nucleotide deletion recently detected in the mannose-binding lectin 2 gene in purebred and crossbred domestic pigs was not found among 68 wild boars representing 4 populations from europe and asia. this suggests that the deletion is a result of breeding and/or genetic drift/bottle necks. | 2015 | 25809846 |
| atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins. | atrial fibrillation (af) and heart failure (hf) are two of the most common cardiovascular diseases. they often coexist and account for significant morbidity and mortality. alterations in cellular ca2+ homeostasis play a critical role in af initiation and maintenance. this study was designed to specifically elucidate af-associated remodeling of atrial ca2+ cycling in the presence of mild hf. af was induced in domestic pigs by atrial burst pacing. the animals underwent electrophysiologic and echoc ... | 2015 | 25775120 |
| establishing a reproducible hypertrophic scar following thermal injury: a porcine model. | our complete understanding of hypertrophic scarring is still deficient, as portrayed by the poor clinical outcomes when treating them. to address the need for alternative treatment strategies, we assess the swine animal burn model as an initial approach for immature scar evaluation and therapeutic application. | 2015 | 25750848 |
| crimped braided sleeves for soft, actuating arm in robotic abdominal surgery. | this paper investigates different types of crimped, braided sleeve used for a soft arm for robotic abdominal surgery, with the sleeve required to contain balloon expansion in the pneumatically actuating arm while it follows the required bending, elongation and diameter reduction of the arm. | 2015 | 25744663 |
| effectiveness of microsatellite and single nucleotide polymorphism markers for parentage analysis in european domestic pigs. | parentage analysis and individual identification are recent, promising methods that have been applied to evolutionary and ecological studies, as well as conservation management. parental exclusion relying on polymorphic microsatellites has been used worldwide in parentage determination, while the low mutation rate and genotyping error rate of single nucleotide polymorphisms (snps) make them another important marker for pedigree tracing. here, we compared the effectiveness of microsatellites and ... | 2015 | 25730075 |