Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| cellular cardiomyoplasty into infracted swine's hearts by retrograde infusion through the venous coronary sinus: an experimental study. | the aim was to create a model of myocardial infarction with a borderline myocardial impairment which would enable evaluation of the retrograde cellular cardiomyoplasty through the venous coronary sinus in a large animal model. | 2016 | 26953214 |
| gelatin-poly(lactic-co-glycolic acid) scaffolds with oriented pore channel architecture - from in vitro to in vivo testing. | a gelatin-poly(lactic-co-glycolic acid), plga, composite scaffold, featuring a highly oriented pore channel structure, was developed as a template for articular cartilage regeneration. as a design principle the composite scaffold was optimized to contain only medical grade educts and accordingly no chemical cross linking agents or other toxicological relevant substances or methods were used. scaffolds were synthesized using a freeze structuring method combined with an electrochemical process fol ... | 2016 | 26952462 |
| the effect of head up cardiopulmonary resuscitation on cerebral and systemic hemodynamics. | chest compressions during cardiopulmonary resuscitation (cpr) increase arterial and venous pressures, delivering simultaneous bidirectional high-pressure compression waves to the brain. we hypothesized that this may be detrimental and could be partially overcome by elevation of the head during cpr. | 2016 | 26905388 |
| coating of intravascular balloon with paclitaxel prevents constrictive remodeling of the dilated porcine femoral artery due to inhibition of intimal and media fibrosis. | here we investigated how a coating of intravascular balloon with paclitaxel (drug-coated balloon; dcb, freeway™) impacted porcine peripheral artery vascular function and remodeling. domestic swine (n = 54) underwent percutaneous overstretch balloon dilation of femoral and iliac arteries, controlled by angiography and optical coherence tomography (oct). paclitaxel tissue uptake was measured at 1 h and 1, 3, and 9 days post-dilation. at these time-points and at 32 ± 2 days, vascular function of th ... | 2016 | 27388164 |
| experimental taphonomy: post-mortem microstructural modifications in sus scrofa domesticus bone. | bone is a highly specialised form of hard and rigid connective tissue whose histological structure undergoes post-mortem modifications. in taphonomic research, histological examination of bone thin sections is used to investigate these post-mortem microstructural changes in skeletal tissues. in this study, diagenetic modifications in pig skeletal remains (sus scrofa domesticus) which were exposed to different taphonomic conditions as part of a long-term, real-time experiment were examined under ... | 2016 | 27368073 |
| an experimental comparative study on classic tube thoracostomy and thoracostomy with a newly designed thorax drainage catheter. | the collection of fluids, blood, pus, or air in the pleural cavity is a pathological condition requiring pleural drainage. a newly designed thorax drainage catheter in the prototype phase was used in this experimental study to test its efficacy. | 2016 | 27511340 |
| dynamic variables fail to predict fluid responsiveness in an animal model with pericardial effusion. | the reliability of dynamic and volumetric variables of fluid responsiveness in the presence of pericardial effusion is still elusive. the aim of the present study was to investigate their predictive power in a porcine model with hemodynamic relevant pericardial effusion. | 2016 | 27499343 |
| technical note: evaluation of a 160-mm/256-row ct scanner for whole-heart quantitative myocardial perfusion imaging. | the authors investigated the performance of a recently introduced 160-mm/256-row ct system for low dose quantitative myocardial perfusion (mp) imaging of the whole heart. this platform is equipped with a gantry capable of rotating at 280 ms per full cycle, a second generation of adaptive statistical iterative reconstruction (asir-v) to correct for image noise arising from low tube voltage potential/tube current dynamic scanning, and image reconstruction algorithms to tackle beam-hardening, cone- ... | 2016 | 27487900 |
| a naturally hypersensitive glucocorticoid receptor elicits a compensatory reduction of hypothalamus-pituitary-adrenal axis activity early in ontogeny. | we comprehensively characterized the effects of a unique natural gain-of-function mutation in the glucocorticoid receptor (gr), grala610val, in domestic pigs to expand current knowledge of the phenotypic consequences of gr hypersensitivity. cortisol levels were consistently reduced in one-week-old piglets, at weaning and in peripubertal age, probably due to a reduced adrenal capacity to produce glucocorticoids (gc), which was indicated by an adrenocortical thinning in grala610val carriers. adren ... | 2016 | 27440422 |
| romanian wild boars and mangalitza pigs have a european ancestry and harbour genetic signatures compatible with past population bottlenecks. | we aimed to analyse the genetic diversity of romanian wild boars and to compare it with that from other wild boar and pig populations from europe and asia. partial sequencing of the mitochondrial encoded cytochrome b (mt-cyb) gene from 36 romanian wild boars and 36 domestic pigs (mangalitza, bazna and vietnamese breeds) showed that the diversity of romanian wild boars and mangalitza pigs is fairly reduced, and that most of the members of these two populations share a common mt-cyb haplotype. bes ... | 2016 | 27418428 |
| intranasal oxytocin administration in relationship to social behaviour in domestic pigs. | intranasal administration of oxytocin has been shown to alter positive and negative social behaviour. positive social behaviour in pigs (sus scrofa) may be expressed through gentle social nosing, and greater insight in the specific expression hereof might contribute to the current search for positive indicators of animal welfare. we investigated whether oxytocin alters social nosing and whether this is specific to nose-body or nose-nose contact. sixty-four focal female pigs of 13weeks of age (ou ... | 2016 | 27143253 |
| feasibility of three-dimensional placement of human therapeutic stem cells using the intracerebral microinjection instrument. | the ability to safely place viable intracerebral grafts of human-derived therapeutic stem cells in three-dimensional (3d) space was assessed in a porcine model of human stereotactic surgery using the intracerebral microinjection instrument (imi) compared to a conventional straight cannula. | 2016 | 27593216 |
| simulating the epidemiological and economic effects of an african swine fever epidemic in industrialized swine populations. | african swine fever (asf) is a notifiable infectious disease with a considerable impact on animal health and is currently one of the most important emerging diseases of domestic pigs. asf was introduced into georgia in 2007 and subsequently spread to the russian federation and several eastern european countries. consequently, there is a non-negligible risk of asf spread towards western europe. therefore it is important to develop tools to improve our understanding of the spread and control of as ... | 2016 | 27599924 |
| prevalence and consequences of chromosomal abnormalities in canadian commercial swine herds. | structural chromosome abnormalities are well known as factors that reduce fertility rate in domestic pigs. according to large-scale national cytogenetic screening programs that are implemented in france, it is estimated that new chromosome abnormalities occur at a rate of 0.5 % in fertility-unproven boars. | 2016 | 27620715 |
| urinary bladder matrix scaffolds strengthen esophageal hiatus repair. | laparoscopic repair of the hiatal hernia is associated with a recurrence rate between 12% and 42% depending on the defect size. although the impact of hiatal reinforcement on long-term recurrence remains controversial, the main limitation of this approach has been the risk of adverse events related with the use of synthetic materials in the vicinity of the esophagus. | 2016 | 27565070 |
| influence of chest compressions on circulation during the peri-cardiac arrest period in porcine models. | starting chest compressions immediately after a defibrillation shock might be harmful, if the victim already had a return of spontaneous circulation (rosc) and yet was still being subjected to external compressions at the same time. the objective of this study was to study the influence of chest compressions on circulation during the peri-cardiac arrest period. | 2016 | 27168071 |
| using 300 pretreatment shock waves in a voltage ramping protocol can significantly reduce tissue injury during extracorporeal shock wave lithotripsy. | pretreating a pig kidney with 500 low-energy shock waves (sws) before delivering a clinical dose of sws (2000 sws, 24 kv, 120 sws/min) has been shown to significantly reduce the size of the hemorrhagic lesion produced in that treated kidney, compared with a protocol without pretreatment. however, since the time available for patient care is limited, we wanted to determine if fewer pretreatment sws could be used in this protocol. as such, we tested if pretreating with 300 sws can initiate the sam ... | 2016 | 27307070 |
| search for a reliable model for bisphosphonate-related osteonecrosis of the jaw: establishment of a model in pigs and description of its histomorphometric characteristics. | the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (bronj) remains unknown, and the development of a reliable experimental model would help to improve our understanding of it. we used 12 domestic pigs of which 6 made up the experimental group and were treated with zoledronate 4mg intravenously weekly for 5 weeks, while the control group (n=6) were given no drugs. on day 60 the right second maxillary and mandibular third molars were extracted. thirty days later 3 animals in each ... | 2016 | 27282083 |
| microwave versus saline-linked radiofrequency (aquamantys) assisted liver resection in a porcine liver resection model. a safety and feasibility pilot study. | the aim of this study was to compare the feasibility, efficacy and safety of microwave ablation and saline-linked radiofrequency (aquamantys) in liver resection. | 2016 | 27273952 |
| targeted gene knockin in porcine somatic cells using crispr/cas ribonucleoproteins. | the pig is an ideal large animal model for genetic engineering applications. a relatively short gestation interval and large litter size makes the pig a conducive model for generating and propagating genetic modifications. the domestic pig also shares close similarity in anatomy, physiology, size, and life expectancy, making it an ideal animal for modeling human diseases. often, however, the technical difficulties in generating desired genetic modifications such as targeted knockin of short stre ... | 2016 | 27240344 |
| functional plasticity of adipose-derived stromal cells during development of obesity. | obesity is a major risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer. expansion of the adipose mass requires adipocyte precursor cells that originate from multipotent adipose-derived stromal cells (ascs), which in turn also participate in repair activities. asc function might decline in a disease milieu, but it remains unclear whether asc function varies during the development of obesity. we tested the hypothesis that microenvironmental inflamm ... | 2016 | 27177576 |
| hyperpolarized13c,15n2-urea mri for assessment of the urea gradient in the porcine kidney. | a decline in cortico-medullary osmolality gradient of the kidney may serve as an early indicator of pathological disruption of the tubular reabsorption process. the purpose of this study was to investigate the feasibility of hyperpolarized13c,15n2-urea mri as a biomarker of renal function in healthy porcine kidneys resembling the human physiology. | 2016 | 27670826 |
| comparison of microchip transponder and noncontact infrared thermometry with rectal thermometry in domestic swine (sus scrofa domestica). | during disease outbreaks, core temperature is a useful health metric in swine, due to the presence of pyrexia especially during the acute phase of infection. despite technologic advances in other facets of swine production and health management, rectal thermometry continues to be the 'gold standard' for measuring core body temperature. however, for various reasons, collecting rectal temperatures can be difficult and unsafe depending on the housing modality. in addition, the delay between inserti ... | 2016 | 27657715 |
| the effect of long-term amiodarone administration on myocardial fibrosis and evolution of left ventricular remodeling in a porcine model of ischemic cardiomyopathy. | amiodarone is effective in suppressing arrhythmias in heart failure patients. we investigated the effect of long-term amiodarone administration on myocardial fibrosis and left ventricular (lv) remodeling in a porcine model of ischemic cardiomyopathy. eighteen infarcted farm pigs were randomized to receive long-term amiodarone administration for 3 months (n = 9) or conventional follow-up (n = 9). evolution of lv remodeling over 3 months post-myocardial infarction was examined at tissue level (myo ... | 2016 | 27652141 |
| genomic analysis reveals selection in chinese native black pig. | identification of genomic signatures that help reveal mechanisms underlying desirable traits in domesticated pigs is of significant biological, agricultural and medical importance. to identify the genomic footprints left by selection during domestication of the enshi black pig, a typical native and meat-lard breed in china, we generated about 72-fold coverage of the pig genome using pools of genomic dna representing three different populations of enshi black pigs from three different locations. ... | 2016 | 27808243 |
| minimally invasive beat-by-beat monitoring of cardiac power in normal hearts and during acute ventricular dysfunction. | cardiac power, the product of aortic flow and blood pressure, appears to be a fundamental cardiovascular parameter. the simplified version named cardiac power output (cpo), calculated as the product of cardiac output (co) in l/min and mean arterial pressure (map) in mmhg divided by 451, has shown great ability to predict outcome in a broad spectrum of cardiac disease. beat-by-beat evaluation of cardiac power (pwr) therefore appears to be a possibly valuable addition when monitoring circulatory u ... | 2016 | 27702881 |
| novel y-chromosome short tandem repeats in sus scrofa and their variation in european wild boar and domestic pig populations. | y-chromosome markers are important tools for studying male-specific gene flow within and between populations, hybridization patterns and kinship. however, their use in non-human mammals is often hampered by the lack of y-specific polymorphic markers. we identified new male-specific short tandem repeats (strs) in sus scrofa using the available genome sequence. we selected four polymorphic loci (5-10 alleles per locus), falling in one duplicated and two single-copy regions. a total of 32 haplotype ... | 2016 | 27558303 |
| flexible growing rods: a biomechanical pilot study of polymer rod constructs in the stability of skeletally immature spines. | surgical treatments for early onset scoliosis (eos) correct curvatures and improve respiratory function but involve many complications. a distractible, or 'growing rod,' implant construct that is more flexible than current metal rod systems may sufficiently correct curves in small children and reduce complications due to biomechanical factors. the purpose of this pilot study was to determine ranges of motion (rom) after implantation of simulated growing rod constructs with a range of clinically ... | 2016 | 27689140 |
| comparison of bipolar radiofrequency ablation zones in an in vivo porcine model: correlation of histology and gross pathological findings. | continuing research ex vivo and in vivo with animal models is performed to advance the oncological safety of radiofrequency ablation (rfa) of liver tumors. in these experiments, frequently imaging modalities (e.g. mri or ct) or macro-morphological measurements are used to determine the full extent of the different ablation zones inside of rfa lesions. however, no systematic study has been performed so far, which verified the accuracy of the macro-morphological findings. therefore, the present st ... | 2016 | 27858704 |
| comparable vascular response of a new generation sirolimus eluting stents when compared to fluoropolymer everolimus eluting stents in the porcine coronary restenosis model. | novel sirolimus eluting stents (ses) have shown non-inferior clinical outcomes when compared to everolimus eluting stents (ees), however only limited preclinical data have been published. therefore, we evaluate vascular response of a new generation biodegradable polymer ses (bp-ses: alex plus, balton) and fluoropolymer ees (ees: xience pro, abbott) in the porcine coronary restenosis model. | 2016 | 27976797 |
| evaluation of dry feeding and liquid feeding to lactating sows under high temperature environment. | liquid feeding system has been introduced to domestic swine farms, but negative cognition about liquid feeding system has been remained for feed waste decay related with poor management and microbial contamination. for these reasons, this study was conducted to evaluate the effects of feeding method in lactating sows. | 2016 | 27795834 |
| social support modulates stress-related gene expression in various brain regions of piglets. | the presence of an affiliative conspecific may alleviate an individual's stress response in threatening conditions. however, the mechanisms and neural circuitry underlying the process of social buffering have not yet been elucidated. using the domestic pig as an animal model, we examined the effect of a 4-h maternal and littermate deprivation on stress hormones and on mrna expression of the glucocorticoid receptor (gr), mineralocorticoid receptor (mr), 11ß-hydroxysteroid dehydrogenase (11ß-hsd) ... | 2016 | 27965550 |
| control of african swine fever epidemics in industrialized swine populations. | african swine fever (asf) is a notifiable infectious disease with a high impact on swine health. the disease is endemic in certain regions in the baltic countries and has spread to poland constituting a risk of asf spread toward western europe. therefore, as part of contingency planning, it is important to explore strategies that can effectively control an epidemic of asf. in this study, the epidemiological and economic effects of strategies to control the spread of asf between domestic swine he ... | 2016 | 27938676 |
| establishment and characterization of porcine focal cerebral ischemic model induced by endothelin-1. | due to well-developed circle of willis in pigs, it is technically challenging to make persistent focal ischemic stroke based on occlusion of cerebral arteries. endothelin-1 could cause a focal lesion by forcing transient but strong vasoconstriction in the circumscribed injected area. its use in porcine stroke model has drawn attention lately. however, all the porcine endothelin-1 induced models were euthanized soon after surgery. whether the brain lesion is persistent, and whether they could cau ... | 2016 | 27773792 |
| diaphragmatic hernia of the stomach with gastric rupture in a domestic pig. | a 5.5-mo-old castrated, male red duroc pig presented acutely with depression and abdominal pain 9 d after an altercation with another pig. a ct examination indicated right pneumothorax and herniation of the stomach into the thoracic cavity. due to a poor prognosis, the pig was euthanized. a necropsy and gross examination revealed a tear of the diaphragmatic muscle in the region of the esophageal hiatus through which the stomach was displaced into the right side of the thoracic cavity. in additio ... | 2016 | 27780007 |
| cardioprotective effects of intracoronary administration of 4-chlorodiazepam in small and large animal models of ischemia-reperfusion. | the translocator protein (tspo) of the mitochondrial membrane has been recognized as a potential therapeutic target for mitigation of myocardial ischemia-reperfusion injury. administration of 4-chlorodiazepam (4-cld), a tspo ligand, has been shown to confer acute cardioprotective effects in small animals; however, long-term studies and studies in clinically-relevant large animal models are lacking. in the present study we investigated a potential cardioprotective effect of intracoronary administ ... | 2016 | 27643472 |
| reproductive ratio for the local spread of african swine fever in wild boars in the russian federation. | african swine fever (asf) has caused the swine industry of the russian federation substantial economic losses over the last 7 years, and the disease spread from there to a number of neighbouring countries. wild boar has been involved in the spread of the disease both at local and at transboundary levels. understanding asf dynamics in wild boars is prerequisite to preventing the spread and to designing and applying effective surveillance and control plans. the reproductive ratio (r0) is an epidem ... | 2016 | 25704269 |
| frequency of vascular inflammation and impact on neointimal proliferation of drug eluting stents in porcine coronary arteries. | we aimed to describe the frequency of vascular inflammatory reactions with second generation drug eluting stents (des) compared to first generation des, and analyze the impact on inflammation and neointimal proliferation in a porcine coronary model. | 2016 | 27713606 |
| a usability comparison of laser suction handpieces for percutaneous nephrolithotomy. | the holmium laser has revolutionized the practice of minimally invasive endoscopy for kidney stones. recently, a novel, rigid handpiece for use in percutaneous nephrolithotomy (pcnl) that couples the holmium laser with suction has been developed. to date, limited data exist regarding the usability and ergonomics of such treatment systems. we thus sought to compare surgeon-rated usability with three different suction laser handpieces in a porcine model. | 2016 | 27758119 |
| biological effect on restenosis and vascular healing of encapsulated paclitaxel nanocrystals delivered via coated balloon technology in the familial hypercholesterolaemic swine model of in-stent restenosis. | the aim of this study was to evaluate the biological efficacy of a novel lower-dose (2.5 µg/mm2) encapsulated paclitaxel nanocrystal-coated balloon (nano-pcb) in the familial hypercholesterolaemic swine (fhs) model of iliofemoral in-stent restenosis. | 2016 | 27753601 |
| in-depth proteomic analysis of the porcine retina by use of a four step differential extraction bottom up lc ms platform. | the eye of the house swine (sus scrofa domestica linnaeus, 1758) represents a promising model for the study of human eye diseases encircling neurodegenerative retina disorders that go along with proteomic changes. to provide an in-depth view into the "normal" (untreated & healthy) porcine retina proteome as an important reference, a proteomic strategy has been developed encircling stepwise/differential extraction, lc ms and peptide de novo sequencing. accordingly, pooled porcine retina homogenat ... | 2016 | 27796761 |
| pilot in vivo study of an absorbable polydioxanone vena cava filter. | the objectives of this study were to evaluate tensile strength retention of polydioxanone as a function of time in a swine venous system and to assess the feasibility of an absorbable inferior vena cava (ivc) filter made from polydioxanone in a pilot swine study. | 2015 | 26992619 |
| first detection of sarcoptic mange in free-ranging wild boar (sus scrofa) in switzerland. | in switzerland sarcoptic mange is frequent in free-ranging wild carnivores but until recent years no cases had been recorded in wild ungulates. since 2010, cases have been observed in wild boar in the cantons of solothurn, tessin and thurgau. here, we report the detection of mange-like skin lesions in wild boars by photo-trapping and the post-mortem findings in 6 culled animals presenting different stages of the disease. potential sources of infection include mangy red foxes, outdoor domestic pi ... | 2015 | 26753342 |
| the control of classical swine fever in wild boar. | classical swine fever (csf) is a viral disease with severe economic consequences for domestic pigs. natural hosts for the csf virus (csfv) are members of the family suidae, i.e., eurasian wild boar (sus scrofa) are also susceptible. csf in wild boar poses a serious threat to domestic pigs. csfv is an enveloped rna virus belonging to the pestivirus genus of the flaviviridae family. transmission of the infection is usually by direct contact or by feeding of contaminated meat products. in recent de ... | 2015 | 26594202 |
| establishment of a new pull-out strength testing method to quantify early osseointegration-an experimental pilot study. | the animal study aims to evaluate a new experimental model for measuring sole the influence of the surface characteristics independent from implant macro-design on the level of osseointegration by registering the pull-out strength needed for removal of experimental devices with different surfaces from artificial defects. | 2015 | 26616405 |
| an initial investigation into the ecology of culturable aerobic postmortem bacteria. | postmortem microorganisms are increasingly recognized for their potential to serve as physical evidence. yet, we still understand little about the ecology of postmortem microbes, particularly those associated with the skin and larval masses. we conducted an experiment to characterize microbiological and chemical properties of decomposing swine (sus scrofa domesticus) carcasses on the island of oahu, hawaii, usa, during june 2013. bacteria were collected from the head, limb, and larval mass durin ... | 2015 | 26654073 |
| transgastric endoscopic gastrojejunostomy using holing followed by interrupted suture technique in a porcine model. | to demonstrate the feasibility and reproducibility of a pure natural orifice transluminal endoscopic surgery (notes) gastrojejunostomy using holing followed by interrupted suture technique using a single endoloop matched with a pair of clips in a non-survival porcine model. | 2015 | 26504508 |
| heart rate variability in porcine progressive peritonitis-induced sepsis. | accumulating evidence suggests that heart rate variability (hrv) alterations could serve as an indicator of sepsis progression and outcome, however, the relationships of hrv and major pathophysiological processes of sepsis remain unclear. therefore, in this experimental study hrv was investigated in a clinically relevant long-term porcine model of severe sepsis/septic shock. hrv was analyzed by several methods and the parameters were correlated with pathophysiological processes of sepsis. in 16 ... | 2015 | 26779039 |
| [regularity of agonal respiration after untreated cardiac arrest in a swine model]. | to explore the regularity of incidence of agonal respiration (ar) and agonal respiration frequency rate (arfr) during untreated cardiac arrest (ca) after ventricular fibrillation (vf) in a swine model. | 2015 | 27318343 |
| lungs exposed to 1 hour warm ischemia without heparin before harvesting might be suitable candidates for transplantation. | the limiting factor for lung transplantation is the lack of donor organs. the usage of lungs from donation after cardiac death (dcd) would dramatically increase donor availability. in the present paper we wanted to investigate lungs exposed to 1 h of warm ischemia without heparin followed by flush-perfusion and cold storage compared to lungs harvested from heart beating donors (hbd) using standard harvesting technique. | 2015 | 26500001 |
| influence of internal fixation systems on radiation therapy for spinal tumor. | in this study, the influence of internal fixation systems on radiation therapy for spinal tumor was investigated in order to derive a theoretical basis for adjustment of radiation dose for patients with spinal tumor and internal fixation. based on a common method of internal fixation after resection of spinal tumor, different models of spinal internal fixation were constructed using the lumbar vertebra of fresh domestic pigs and titanium alloy as the internal fixation system. variations in radia ... | 2015 | 26219011 |
| characterization of a porcine model for associating liver partition and portal vein ligation for a staged hepatectomy. | publications using the alpps (associating liver partition and portal vein ligation for a staged hepatectomy) procedure have demonstrated a future liver remnant growth of 40-160% in only 6-9 days. the present study aimed to develop and describe the first large animal model of alpps that can be used for future studies. | 2015 | 26234167 |
| segmental and age differences in the elastin network, collagen, and smooth muscle phenotype in the tunica media of the porcine aorta. | the porcine aorta is often used in studies on morphology, pathology, transplantation surgery, vascular and endovascular surgery, and biomechanics of the large arteries. using quantitative histology and stereology, we estimated the area fraction of elastin, collagen, alpha-smooth muscle actin, vimentin, and desmin within the tunica media in 123 tissue samples collected from five segments (thoracic ascending aorta; aortic arch; thoracic descending aorta; suprarenal abdominal aorta; and infrarenal ... | 2015 | 26232584 |
| intraindividual comparison of image quality using retrospective and prospective respiratory gating for the acquisition of thin sliced four dimensional multidetector ct of the thorax in a porcine model. | to intraindividually compare image quality and anatomical depiction of the lung and mediastinum using retrospective and prospective respiratory gating techniques for the acquisition of 4d-multidetector computed tomography (mdct) of the chest in a porcine model. | 2015 | 26495957 |
| effects of hydrogen sulfide (h2s) on mesenteric perfusion in experimental induced intestinal ischemia in a porcine model. | insufficient mesenteric perfusion is a dramatic complication in critically ill patients. hydrogen sulfide, a newly recognized endogenous gaseous mediator, acts as an intestinal vasoactive agent and seems to protect against mesenteric ischemic damage. we investigated whether sodium hydrogen sulfide, a hydrogen sulfide donor, can improve mesenteric perfusion in an experimental model of pigs, both in physiological and ischemic conditions. | 2015 | 26495269 |
| pulse oximetry: a non-invasive, novel marker for the quality of chest compressions in porcine models of cardiac arrest. | pulse oximetry, which noninvasively detects the blood flow of peripheral tissue, has achieved widespread clinical use. we have noticed that the better the quality of cardiopulmonary resuscitation (cpr), the better the appearance of pulse oximetry plethysmographic waveform (pop). we investigated whether the area under the curve (auc) and/or the amplitude (amp) of pop could be used to monitor the quality of cpr. | 2015 | 26485651 |
| morphological aspects and physical properties of enamel and dentine of sus domesticus: a tooth model in laboratory research. | this study aims to describe and analyze morphological and physical properties of deciduous teeth of sus domesticus. ultrastructural analysis, mineral composition and microhardness of enamel and dentine tissues were performed on 10 skulls of s. domesticus. external anatomic characteristics and the internal anatomy of the teeth were also described. data regarding microhardness and ultrastructural analysis were subjected to statistical tests. for ultrastructural analysis, we used the analysis of va ... | 2015 | 26434756 |
| experimental transmission of african swine fever (asf) low virulent isolate nh/p68 by surviving pigs. | african swine fever (asf) has persisted in eastern europe since 2007, and two endemic zones have been identified in the central and southern parts of the russian federation. moderate- to low-virulent asf virus isolates are known to circulate in endemic asf-affected regions. to improve our knowledge of virus transmission in animals recovered from asf virus infection, an experimental in vivo study was carried out. four domestic pigs were inoculated with the nh/p68 asf virus, previously characteriz ... | 2015 | 26432068 |
| evolution of coronary flow in an experimental slow flow model in swines: angiographic and pathological insights. | pathomechanism of coronary slow flow phenomenon remains largely unclear now. present study observed the pathological and angiographic evolution in a pig model of coronary slow flow. | 2015 | 26539516 |
| developing a kinematic understanding of chest compressions: the impact of depth and release time on blood flow during cardiopulmonary resuscitation. | effective cardiopulmonary resuscitation is a critical component of the pre-hospital treatment of cardiac arrest victims. mechanical chest compression (mcc) devices enable the delivery of mcc waveforms that could not be delivered effectively by hand. while chest compression generated blood flow has been studied for more than 50 years, the relation between sternum kinematics (depth over time) and the resulting blood flow have not been well described. using a five parameter mcc model, we studied th ... | 2015 | 26537881 |
| experimental study of kinematic activity of left ventricular myocardium. | a method of invasive and non-invasive examination of epicardial motion was tested on domestic pigs (n=15). the invasive study employed a contact kinematic sensor of the epicardial wall motion, which determined the amplitude, velocity, and angular parameters of examined epicardial region. a non-invasive assessment of the epicardial kinematics based on echocardiographic 2d velocity vector imaging and ecg recoding used to determine the heart electrical axis. the 4-chamber views were uses to analyze ... | 2015 | 26531214 |
| [uterine neoplasia in two geriatric miniature pet pigs - diagnostics and therapy. two case reports]. | miniature pet pigs are becoming ever more common among the patients of small animal practices. due to an advanced age attained in these animals in comparison with conventional pigs in pork production, miniature pet pigs develop age-related diseases that are infrequently observed in farm pigs, including neoplastic alterations of the uterus. we describe two cases of a uterine adenocarcinoma and a leiomyoma, respectively, in two miniature pet pig sows. options and limits of diagnostic measures (uns ... | 2015 | 26530159 |
| changes in saliva biomarkers of stress and immunity in domestic pigs exposed to a psychosocial stressor. | a combination of salivary biomarkers measured at the same time, reflecting the different systems that are involved in the stress mechanism, could be the best tool for its evaluation. in this study, changes in a panel of salivary biomarkers of stress and immunity including chromogranin a (cga), iga, cortisol, testosterone, haptoglobin (hp) and c-reactive protein (crp), were evaluated. a total of 14 (7 control and 7 test) crossbred duroc × (landrace × large white) males of 190 days of age were use ... | 2015 | 26412517 |
| human recombinant activated protein c-coated stent for the prevention of restenosis in porcine coronary arteries. | activated protein c (apc), an endogenous protein, inhibits inflammation and thrombosis and interrupts the coagulation cascade. here, we investigated the effect of human recombinant apc on the development of neointimal hyperplasia in porcine coronary arteries. yukon choice bare metal stents were coated with 2.6 µg apc/mm(2). under general anesthesia, apc-coated and bare stents were implanted in the left anterior descending and circumflex coronary arteries of 10 domestic pigs. during the 4-week fo ... | 2015 | 26411437 |
| african swine fever: a global view of the current challenge. | african swine fever (asf) is an important contagious haemorrhagic viral disease affecting swine whose notification is mandatory due to its high mortality rates and the great sanitary and socioeconomic impact it has on international trade in animal and swine products. this disease only affects porcine species, both wild and domestic, and produces a variety of clinical signs such as fever and functional disorders of the digestive and respiratory systems. lesions are mainly characterized by congest ... | 2015 | 28405426 |
| volume infusion cooling increases end-tidal carbon dioxide and results in faster and deeper cooling during intra-cardiopulmonary resuscitation hypothermia induction. | intra-arrest hypothermia induction may provide more benefit than inducing hypothermia after return of spontaneous circulation. however, little is understood about the interaction between patient physiology and hypothermia induction technology choice during ongoing chest compressions. | 2015 | 26715581 |
| blood collection from the orbital sinus of swine. | swine (sus scrofa domesticus) are increasingly used as animal models in biomedical research. often blood samples from these animals are needed for research protocols, but phlebotomy can be difficult, especially with young swine. this column describes a relatively simple technique for blood collection that can be used specifically with young swine. | 2015 | 26398611 |
| shifts in soil biodiversity-a forensic comparison between sus scrofa domesticus and vegetation decomposition. | in a forensic context, microbial-mediated cadaver decomposition and nutrient recycling cannot be overlooked. as a result, forensic ecogenomics research has intensified to gain a better understanding of cadaver/soil ecology interactions as a powerful potential tool for forensic practitioners. for this study, domestic pig (sus scrofa domesticus) (4g) and grass (agrostis/festuca spp) cuttings (4g) were buried (july 2013 to july 2014) in sandy clay loam (80 g) triplicates in sealed microcosms (127 m ... | 2015 | 26654074 |
| longitudinal study of the early-life fecal and nasal microbiotas of the domestic pig. | the mammalian microbiota plays a key role in host health and disease susceptibility. however, knowledge of the early-age microbiota of pigs is lacking. the purpose of this study was to use high-throughput next-generation sequencing to characterize the fecal and nasal microbiotas of pigs during early life. | 2015 | 26391877 |
| coronary injury score correlates with proliferating cells and alpha-smooth muscle actin expression in stented porcine coronary arteries. | neointimal formation and cell proliferation resulting into in-stent restenosis is a major pathophysiological event following the deployment of stents in the coronary arteries. in this study, we assessed the degree of injury, based on damage to internal elastic lamina, media, external elastic lamina, and adventitia following the intravascular stenting, and its relationship with the degree of smooth muscle cell proliferation. we examined the smooth muscle cell proliferation and their phenotype at ... | 2015 | 26382957 |
| lymphatic territories (lymphosomes) in swine: an animal model for future lymphatic research. | the swine is a common preclinical large-animal model for medical research because of the resemblance of its tissue structures to those of humans. however, the lymphatic system in swine is poorly understood. the authors investigated the lymphatic system and defined territories (lymphosomes) in swine using the microinjection technique. | 2015 | 26218378 |
| xromm analysis of tooth occlusion and temporomandibular joint kinematics during feeding in juvenile miniature pigs. | like humans, domestic pigs are omnivorous and thus are a common model for human masticatory function. prior attempts to characterize food-tooth interactions and jaw movements associated with mastication have been limited to aspects of the oral apparatus that are visible externally (with videography) and/or to 2d movements of oral structures (with monoplanar videofluoroscopy). we used xromm, a 3d technique that combines ct-based morphology with biplanar videofluoroscopy, to quantify mandibular ki ... | 2015 | 26089531 |
| human microbiota-associated swine: current progress and future opportunities. | gnotobiotic (gn) rodent models have provided insight into the contributions of the gut microbiota to host health and preventing disease. however, rodent models are limited by several important physiological and metabolic differences from humans, and many rodent models do not dependably replicate the clinical manifestations of human diseases. due to the high degree of similarity in anatomy, physiology, immunology and brain growth, the domestic pig (sus scrofa) is considered a clinically relevant ... | 2015 | 25991699 |
| origins and neurochemical complexity of preganglionic neurons supplying the superior cervical ganglion in the domestic pig. | the superior cervical ganglion (scg) is a center of sympathetic innervation of all head and neck organs. scg sympathetic preganglionic neurons (spn) were found in the nucleus intermediolateralis pars principalis (imlpp), the nucleus intermediolateralis pars funicularis (imlpf), the nucleus intercalatus spinalis (ic), and the nucleus intercalatus spinalis pars paraependymalis (icpe). despite its importance, little is known of scg innervation and chemical coding in the laboratory pig, a model that ... | 2015 | 24854048 |
| phenotypic and functional differentiation of porcine αβ t cells: current knowledge and available tools. | domestic pigs are considered as a valuable large animal model because of their close relation to humans in regard to anatomy, genetics and physiology. this includes their potential use as organ donors in xenotransplantation but also studies on various zoonotic infections affecting pigs and humans. such work also requires a thorough understanding of the porcine immune system which was partially hampered in the past by restrictions on available immunological tools compared to rodent models. howeve ... | 2015 | 25466616 |
| in vivo tracking and immunological properties of pulsed porcine monocyte-derived dendritic cells. | cellular therapies using immune cells and in particular dendritic cells (dcs) are being increasingly applied in clinical trials and vaccines. their success partially depends on accurate delivery of cells to target organs or migration to lymph nodes. delivery and subsequent migration of cells to regional lymph nodes is essential for effective stimulation of the immune system. thus, the design of an optimal dc therapy would be improved by optimizing technologies for monitoring dc trafficking. magn ... | 2015 | 25282042 |
| histopathological comparative analysis of peri-implant soft tissue response after dental implant placement with flap and flapless surgical technique. experimental study in pigs. | the aim of this study was comparing the effect of flapless vs. flap technique of implant placement on inflammation degree of peri-implant soft tissue, through histopathological analysis. | 2015 | 25039366 |
| efficacy and safety of novel epicardial circumferential left atrial ablation with pulmonary vein isolation in sustained atrial fibrillation. | the aim of this study was to examine the efficacy and safety of this novel epicardial circumferential left atrial ablation (claa) with pulmonary vein isolation (pvi) in sustained atrial fibrillation (af). thirty domestic pigs were divided equally into 3 groups: af without ablation (af group), af with pvi (pvi group), and af with claa and pvi (claa + pvi group). af was induced by rapid atrial pacing. after af was induced, claa and pvi were performed for pigs in claa + pvi group, and pvi was perfo ... | 2015 | 25323730 |
| immunohistochemical evidence of leptin and its receptor in the carpal glands of domestic pigs and wild boar. | in recent years, the protein hormone leptin has been the subject of numerous studies designed to clarify and interpret its functional significance; it has been speculated that this goes well beyond the control of appetite and energy metabolism. in particular, the presence of leptin and its receptor has been observed in various glands anatomically and functionally related to the reproductive apparatus. this has led to the hypothesis that leptin may act directly in the functional control of these ... | 2015 | 25292333 |
| generation of crispr/cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. | the domestic pig has been widely used as an important large animal model. precise and efficient genetic modification in pig provides a great promise in biomedical research. recently, clustered regularly interspaced short palindromic repeat (crispr)/crispr-associated (cas) system has been successfully used to produce many gene-targeted animals. however, these animals have been generated by co-injection of cas9 mrna and single-guide rna (sgrna) into one-cell stage embryos, which mostly resulted in ... | 2015 | 25274063 |
| mitochondrial dna sequence and phylogenetic evaluation of geographically disparate sus scrofa breeds. | next generation sequencing of mitochondrial dna (mtdna) facilitates studies into the metabolic characteristics of production animals and their relation to production traits. sequence analysis of mtdna from pure-bred swine with highly disparate production characteristics (mangalica blonde, mangalica swallow-bellied, meishan, turopolje, and yorkshire) was initiated to evaluate the influence of mtdna polymorphisms on mitochondrial function. herein, we report the complete mtdna sequences of five sus ... | 2015 | 25153451 |
| voluderm microneedle technology for skin treatments-in vivo histological evidence. | the growing demand for skin rejuvenation procedures with minimal down time and low risk has led to the development of fractional radiofrequency (rf) systems. the new voluderm™ rf microneedle technology creates minute columns of tissue thermal microablation. treatment triggers natural fractional healing, resulting in dermal volumizing and skin renewal. this preclinical research assessed the safety and efficacy of the voluderm through histological evaluation of morphological changes in the target ... | 2015 | 25151912 |
| preliminary observations of arthropods associated with buried carrion on oahu. | several studies in hawaii have focused on arthropod succession and decomposition patterns of surface remains, but the current research presents the first study to focus on shallow burials in this context. three domestic pig carcasses (sus scrofa l.) were buried at the depths of 20-40 cm in silty clay loam soil on an exposed ridge on the leeward side of the volcanically formed koolau mountain range. one carcass was exhumed after 3 weeks, another after 6 weeks, and the last carcass was exhumed aft ... | 2015 | 25413711 |
| active dynamic infrared thermal imaging in burn depth evaluation. | the aim of this study was to find the relationship between active dynamic thermography (adt) with cold excitation and burn depth. this new modality of evaluation of burns seems to be an attractive proposal for quantitative classification, allowing proper choice of burn wound treatment: conservative or surgical, especially compared with static thermography. the work was an in vivo experiment on domestic pigs, and a small number of patients were also diagnosed as part of the study. statistical ana ... | 2015 | 25144810 |
| computed tomography for planning and postoperative imaging of transvenous mitral annuloplasty: first experience in an animal model. | to investigate the use of computed tomography (ct) to measure the mitral valve annulus size before implantation of a percutaneous mitral valve annuloplasty device in an animal trial. seven domestic pigs underwent ct before and after implantation of a cardioband™ (a percutaneously implantable mitral valve annuloplasty device) with a second-generation 128-section dual-source ct machine. implantation of the cardioband™ was performed in a standard fashion according to a protocol. animals were sacrif ... | 2015 | 25119889 |
| safety and biocompatibility of a novel self-expanding nitinol carotid stent with hybrid cell design in a porcine model of neointimal hyperplasia. | stent design may influence the outcomes, suggesting that adverse event rates vary according to free cell area and cell design. open cell design technology of self-expandable stents, dedicated for carotid revascularisation has better deliverability, although closed cell technology is expected to cause fewer thromboembolic events. | 2015 | 25371312 |
| genome-wide analysis reveals artificial selection on coat colour and reproductive traits in chinese domestic pigs. | pigs from asia and europe were independently domesticated from c. 9000 years ago. during this period, strong artificial selection has led to dramatic phenotypic changes in domestic pigs. however, the genetic basis underlying these morphological and behavioural adaptations is relatively unknown, particularly for indigenous chinese pigs. here, we performed a genome-wide analysis to screen 196 regions with selective sweep signals in tongcheng pigs, which are a typical indigenous chinese breed. gene ... | 2015 | 25132237 |
| sodium nitroprusside-enhanced cardiopulmonary resuscitation facilitates intra-arrest therapeutic hypothermia in a porcine model of prolonged ventricular fibrillation. | the aim of this study was to assess the effect of sodium nitroprusside-enhanced cardiopulmonary resuscitation on heat exchange during surface cooling. we hypothesized that sodium nitroprusside-enhanced cardiopulmonary resuscitation would decrease the time required to reach brain temperature less than 35°c compared to active compression-decompression plus impedance threshold device cardiopulmonary resuscitation alone, in the setting of intra-cardiopulmonary resuscitation cooling. we further hypot ... | 2015 | 25525755 |
| a taphonomic study exploring the differences in decomposition rate and manner between frozen and never frozen domestic pigs (sus scrofa). | this research examined differences in decomposition rate and manner of domestic pig subjects (sus scrofa) in never frozen (control) and previously frozen (experimental) research conditions. eight control and experimental subjects were placed in an identical outdoor research environment. daily quantitative and qualitative measurements were collected: abdominal circumference, total body score (tbs), temperature, photographs, descriptive decomposition stages, and visual observations. field necropsi ... | 2015 | 25693630 |
| modeling cardiac arrest and resuscitation in the domestic pig. | cardiac arrest remains a leading cause of death and permanent disability worldwide. although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, ca(2+) overload, atp depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which ... | 2015 | 25685718 |
| mechanism by which shock wave lithotripsy can promote formation of human calcium phosphate stones. | human stone calcium phosphate (cap) content correlates with higher urine cap supersaturation (ss) and urine ph as well as with the number of shock wave lithotripsy (swl) treatments. swl does damage medullary collecting ducts and vasa recta, sites for urine ph regulation. we tested the hypothesis that swl raises urine ph and therefore cap ss, resulting in cap nucleation and tubular plugging. the left kidney (t) of nine farm pigs was treated with swl, and metabolic studies were performed using bil ... | 2015 | 25656372 |
| domestic pigs' (sus scrofa domestica) use of direct and indirect visual and auditory cues in an object choice task. | recently, foraging strategies have been linked to the ability to use indirect visual information. more selective feeders should express a higher aversion against losses compared to non-selective feeders and should therefore be more prone to avoid empty food locations. to extend these findings, in this study, we present a series of studies investigating the use of direct and indirect visual and auditory information by an omnivorous but selective feeder-the domestic pig. subjects had to choose bet ... | 2015 | 25650328 |
| two-in-one aortic valve sizing and valvuloplasty conductance balloon catheter. | inaccurate aortic valve sizing and selection is linked to paravalvular leakage in transcatheter aortic valve replacement (tavr). here, a novel sizing valvuloplasty conductance balloon (svcb) catheter is shown to be accurate, reproducible, unbiased, and provides real-time tool for aortic valve sizing that fits within the standard valvuloplasty procedure. | 2015 | 25510238 |
| advances in research in animal models of burn-related hypertrophic scarring. | skin burn injuries affect approximately 500,000 people per year in france. after deep burns, functional sequelae associated with hypertrophic and retractile scars are an important public health problem. to understand the pathophysiology of sequelae and evaluate new therapeutic approaches, the use of animal models that should be standard tools is necessary. some pre-clinical models of hypertrophic scars after burns have been described, but the choice of the appropriate and relevant experimental m ... | 2015 | 25356852 |
| tvp1022: a novel cardioprotective drug attenuates left ventricular remodeling after ischemia/reperfusion in pigs. | the current cornerstone treatment of myocardial infarction (mi) is restoration of coronary blood flow by means of thrombolytic therapy or primary percutaneous coronary intervention. however, reperfusion of ischemic myocardium can actually provoke tissue damage, defined as "ischemia-reperfusion (i/r) injury." tvp1022 [the s-isomer of rasagiline (azilect), fda-approved anti-parkinson's drug] was found to exert cardioprotective activities against various cardiac insults, such as chronic heart failu ... | 2015 | 25900266 |
| soil fungal community shift evaluation as a potential cadaver decomposition indicator. | fungi metabolise organic matter in situ and so alter both the bio-/physico-chemical properties and microbial community structure of the ecosystem. in particular, they are responsible reportedly for specific stages of decomposition. therefore, this study aimed to extend previous bacteria-based forensic ecogenomics research by investigating soil fungal community and cadaver decomposition interactions in microcosms with garden soil (20 kg, fresh weight) and domestic pig (sus scrofa domesticus) carc ... | 2015 | 26322496 |
| fluid dynamics simulation of right ventricular outflow tract oversizing. | repair of the right ventricular outflow tract (rvot) in paediatric cardiac surgery remains challenging due to the high reoperation rate. intimal hyperplasia and consequent arteriosclerosis is one of the most important limitation factors for graft durability. since local shear stress and pressure are predictive elements for intimal hyperplasia and wall degeneration, we sought to determine in an oversized 12-mm rvot model, with computed fluid dynamics simulation, the local haemodynamical factors t ... | 2015 | 25912476 |
| atrial fibrillation complicated by heart failure induces distinct remodeling of calcium cycling proteins. | atrial fibrillation (af) and heart failure (hf) are two of the most common cardiovascular diseases. they often coexist and account for significant morbidity and mortality. alterations in cellular ca2+ homeostasis play a critical role in af initiation and maintenance. this study was designed to specifically elucidate af-associated remodeling of atrial ca2+ cycling in the presence of mild hf. af was induced in domestic pigs by atrial burst pacing. the animals underwent electrophysiologic and echoc ... | 2015 | 25775120 |
| establishing a reproducible hypertrophic scar following thermal injury: a porcine model. | our complete understanding of hypertrophic scarring is still deficient, as portrayed by the poor clinical outcomes when treating them. to address the need for alternative treatment strategies, we assess the swine animal burn model as an initial approach for immature scar evaluation and therapeutic application. | 2015 | 25750848 |
| crimped braided sleeves for soft, actuating arm in robotic abdominal surgery. | this paper investigates different types of crimped, braided sleeve used for a soft arm for robotic abdominal surgery, with the sleeve required to contain balloon expansion in the pneumatically actuating arm while it follows the required bending, elongation and diameter reduction of the arm. | 2015 | 25744663 |