Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| Identification of Helicobacter pylori in Skin Biopsy of Prurigo Pigmentosa. | A 23-year-old Chinese man presented with a 3-year history of a pruritic eruption. On examination, pink urticarial papules associated with hyperpigmented reticulated patches were noted on his neck, back, and upper chest. Histopathology revealed vacuolar interface dermatitis and numerous gram-negative rods within a dilated hair follicle. The organisms were reactive with anti-Helicobacter pylori immunohistochemisty. The histologic findings and clinical presentation support the diagnosis of prurigo ... | 2011 | 22197863 |
| barrett's esophagus: natural history. | the following on the natural history of barrett's esophagus (be) includes commentary on histological sequences of the development of barrett mucosa; the transformation of esophageal cells from squamous to columnar phenotype; the stages of natural history of dysplasia; the difficulties of predicting progression of dysplasia to adenocarcinoma; the preferable biopsy protocols; the role of helicobacter pylori infection and gastric atrophy in the risk of be; the value of decrease of proton pump inhib ... | 2011 | 21950819 |
| differential diagnosis of upper gastrointestinal bleeding proximal to the ligament of trietz. | upper gastrointestinal bleeding (ugib) is an important medical problem for patients and the medical system. the causes of ugib are varied and their accurate identification guides appropriate management. the major cause of ugib is peptic ulcer disease, for which helicobacter pylori and nonsteroidal antiinflammatory drug use are major risk factors. lesser causes include dieulafoy lesion, gastric antral vascular ectasia, hemobilia, aortoenteric fistulas, and upper gastrointestinal tumors. awareness ... | 2011 | 21944410 |
| proteomic analysis of upregulated proteins in helicobacter pylori under oxidative stress induced by hydrogen peroxide. | the development of gastric cancer was suggested to be associated with chronic inflammation as a consequence of helicobacter pylori infection. such inflammation-related oxidative stress induced by reactive oxygen species (ros) in vivo may exert bidirectional effects on both hosts and h pylori. in this study, ros-induced oxidative stress was mimicked by coculture of gastric epithelial cells with h pylori treated with hydrogen peroxide (h(2)o(2)). to investigate the effect of h(2)o(2) on the proteo ... | 2011 | 22208537 |
| Unraveling the Helicobacter pylori UreG zinc binding site using X-ray absorption spectroscopy (XAS) and structural modeling. | The pathogenicity of Helicobacter pylori depends on the activity of urease for pH modification. Urease activity requires assembly of a dinickel active site that is facilitated in part by GTP hydrolysis by UreG. The proper functioning of Helicobacter pylori UreG (HpUreG) is dependent on Zn(II) binding and dimerization. X-ray absorption spectroscopy and structural modeling were used to elucidate the structure of the Zn(II) site in HpUreG. These studies independently indicated a site at the dimer i ... | 2011 | 22068961 |
| Key points for designing and reporting Helicobacter pylori therapeutic trials: a personal view. | The aim of this document is to provide a methodological framework and to review key aspects for adequately designing trials to evaluate new treatments for Helicobacter pylori infection. | 2011 | 21923680 |
| treatment of helicobacter pylori infection 2011. | this article reviews the literature published pertaining to helicobacter pylori eradication over the last year. the general perception among clinicians and academics engaged in research on h. pylori has been that eradication rates for first-line therapies are falling, although some data published this year have cast doubt on this. the studies published this year have therefore focussed on developing alternative strategies for the first-line eradication of h. pylori. in this regard, clear evidenc ... | 2011 | 21896086 |
| sequential therapy for h. pylori eradication. | helicobacter pylori eradication therapy helps to prevent recurrence of, and re-bleeding from, gastric and duodenal ulcers. it also causes regression of most localised gastric mucosa-associated lymphoid-tissue (malt) lymphomas. standard triple therapy (comprising a proton pump inhibitor [ppi] plus two antibacterials) has been used routinely to eradicate h. pylori. however, the effectiveness of this type of regimen has declined over time, mainly due to antibacterial resistance. consequently, other ... | 2011 | 21921072 |
| role of helicobacter pylori virulence factors for iron acquisition from gastric epithelial cells of the host and impact on bacterial colonization. | evaluation of: tan s, noto jm, romero-gallo j, peek rm jr, amieva mr. helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface. plos pathog. 7(5), e1002050 (2011). the effects of helicobacter pylori virulence factors on gastric epithelial cells are topics open to many studies. major virulence factors, cytotoxin-associated gene a (caga) and vacuolating cytotoxin (vaca), predict severe infection outcomes in many countries. h. pylori possesses various proteins for ... | 2011 | 21861616 |
| high levels of soluble herpes virus entry mediator in sera of gastric cancer patients. | the development of gastric cancer (gc) is closely related to chronic inflammation caused by helicobacter pylori infection, and herpes virus entry mediator (hvem) is a receptor expressed on the surface of leukocytes that mediates potent inflammatory responses in animal models. however, the role of hvem in human gc has not been studied. previously, we showed that the interaction of hvem on human leukocytes with its ligand light induces intracellular calcium mobilization, which results in inflammat ... | 2011 | 22113134 |
| Antagonistic Activities of Lactobacilli against Helicobacter pylori Growth and Infection in Human Gastric Epithelial Cells. | Lactobacilli have positive effects on bowel microflora and health in humans and animals. In this study, the antagonistic activities of Lactobacillus gasseri Chen, and L. plantarum 18 were assessed by agar plate diffusion assay and tests that determined the growth and urease activity of Helicobacter pylori cocultured with lactobacilli and the adherence of H. pylori to human gastric epithelial cells in the presence of lactobacilli. The results showed that the 2 Lactobacillus strains had signific ... | 2011 | 22181017 |
| performance of routine helicobacter pylori tests in patients with atrophic gastritis. | background. decreased density of h. pylori in atrophic gastritis may lead to low sensitivity of the routine tests. aims. to evaluate the accuracy of routinely used h. pylori tests in atrophic gastritis. methods. we compared 5 h. pylori diagnostic tests in 119 dyspeptic patients (28 males/91 females) with a mean age of 67 years (range 55-84). patients with gastric cancer, peptic ulcer, previous gastric surgery, or those who have received eradication therapy were excluded. the following tests were ... | 2011 | 22187698 |
| Etiopathogenetic principles and peptic ulcer disease classification. | Ulceration corresponds to tissue loss, breaching the muscularis mucosae. When ulcers develop in the acid-peptic environment of the gastroduodenum, they are traditionally called peptic ulcer (PUD). Ulcers never develop spontaneously in a healthy gastroduodenal mucosa. Ulceration is the ultimate consequence of a disequilibrium between aggressive injurious factors and defensive mucosa-protective factors. The dominant aggressors are strong acid and high proteolytic (pepsin) activity in gastric secre ... | 2011 | 22095009 |
| [Current state and measures of NSAIDs induced ulcer]. | In recent years, the incidence of Helicobacter pylori (H. pylori) infection has been decreasing and the incidence of peptic ulcer and bleeding ulcer induced by NSAIDs, especially low-dose aspirin (LDA), have been increasing. PPI and PG are useful for treatment and prevention of ulcers in patients receiving continuous administration of NSAIDs and/or LDA. H. pylori eradication is effective if performed before the start of NSAIDs administration, but a beneficial effect of H. pylori eradication perf ... | 2011 | 22073592 |
| [Morphological features of the gastric mucosa capillary network in patients with portal hypertension]. | The pathogenesis of portal hypertension (PH) involves venous congestion with gastric mucosal capillary dilatation. The formation of new blood vessels, as was shown in experimental models of PH, is pathological hallmark of PH. Generation of new blood vessels is stimulated by vascular endothelial growth factor (VEGF), the regulator of angiogenesis. The aim of the study was to investigate changes in gastric microvessels in patients with liver cirrhosis complicated with PH in different stages, and t ... | 2011 | 22164432 |
| [the significance of h. pylori eradication in nsaids ulcer]. | the significance of h. pylori eradication for nsaids induced gastroduodenal ulcer has not been clarified. nsaids and h. pylori infection are independent causal factors for gastroduodenal mucosal injuries. however, the interaction between these two factors is complicated. h. pylori eradication can reduce the risk of nsaids induced ulcer in nsaids naive patients. however, h. pylori eradication is not recommended in nsaids user because of no ulcer suppression and ulcer healing delay. in prevention ... | 2011 | 21688626 |
| [a case of desulfovibrio desulfuricans cultured from blood in japan]. | we report a case of desulfovibrio desulfuricans bacteremia in a 60-year-old-man. in our case, anaerobic blood culture bottle turned out positive after five days' incubation. gram stain showed the presence of slightly-curved gram negative rod. suspecting campylobacter and helicobacter, we added microaerobic culture while tentatively reporting campylobacter to the physician. we then added anaerobic culturing with brucella hk (rs) agar because microaerobic culture proved the absence of microaerophi ... | 2011 | 21706860 |
| should quinolones come first in helicobacter pylori therapy? | new generations of fluoroquinolones, like levofloxacin and moxifloxacin, exhibit a broad-spectrum activity against gram-positive and gram-negative bacteria, and have been successfully introduced into the treatment of helicobacter pylori infection. based on a large body of evidence, current guidelines recommend the use of levofloxacin- or moxifloxacin-containing proton-pump inhibitor (ppi) triple therapies in second-line or rescue treatment of h. pylori infection. the efficacy of standard ppi tri ... | 2011 | 21694812 |
| duodenal ulcer disease, gastroduodenal motor function and reflux esophagitis - a cross-sectional survey in a subset of taiwanese patients. | backgroundôçé to investigate the association between the gastric emptying rate and the presence of erosive esophagitis in duodenal ulcer (du) patients among a population with high prevalence of helicobacter pylori infection. methodsôçé cross-sectional survey was performed in a cohort of 60 male patients with either active or healed du, with or without the presence of erosive esophagitis. clinical and social-demographic data, blood level of fasting gastrin, pepsinogen i & i/ii ratio, and scintigr ... | 2011 | 21714832 |
| frequency of helicobacter pylori infection using 13c-ubt in asymptomatic individuals of barakaho, islamabad, pakistan. | high frequency of helicobacter (h.) pylori infection has been reported in pakistan mainly for dyspeptic patients, while the published data is inadequate regarding asymptomatic population. the non-invasive 13c urea breath test (ubt) was used to determine the frequency of h. pylori infection in 516 asymptomatic individuals and to find out its association with gender and age. overall prevalence was 74.4% (384/516) while 63.5% (113/178) children were positive for 13c-ubt and the percentage increased ... | 2011 | 21712001 |
| changes of upper gastrointestinal symptoms and endoscopic findings in japan over 25 years. | in japan, the prevalence of helicobacter pylori infection has decreased recently, but there has been little longitudinal research on the changes of symptoms and endoscopic findings over many years. the aim of this study was to evaluate the changes in endoscopic findings and symptoms over time in patients undergoing upper gastrointestinal endoscopy for assessment of upper abdominal symptoms. | 2011 | 21720053 |
| acp journal club. quadruple-drug therapy was better than triple-drug therapy for eradicating helicobacter pylori in adults. | 2011 | 21690580 | |
| Biochemical and Mutational Studies of the Bacillus cereus CECT 5050T Formamidase Support the Existence of a C-E-E-K Tetrad in Several Members of the Nitrilase Superfamily. | Formamidases (EC 3.5.1.49) are poorly characterized proteins. In spite of this scarce knowledge, ammonia has been described as playing a central role in the pathogenesis of human pathogens such as Helicobacter pylori, for which formamidase has been shown to participate in the nitrogen metabolic pathway. Sequence analysis has revealed that at least two different groups of formamidases are classified as EC 3.5.1.49: on the one hand, the derivatives of the FmdA-AmdA superfamily, which are the best ... | 2011 | 21705545 |
| A case of candidal infection of gastric ulcers with characteristic endoscopic findings. | While Candida infection is a common opportunistic infection, Candida-associated gastric lesions are far less frequent. We report a case of gastric ulcers due to candidal infection. A 73-year-old woman had ulcers refractory to treatment with a proton pump inhibitor (PPI) and Helicobacter pylori eradication. Endoscopic findings showed that this case involved 2 gastric ulcers with thick exudate mainly located in the fornix. Biopsy specimens from gastric ulcers revealed numerous Candida forms. The p ... | 2011 | 21817842 |
| helicobacter pylori and type 1 diabetes mellitus: possibility of modifying chronic disease susceptibility with vaccinomics at the anvil. | the human gastric pathogen, helicobacter pylori, colonizes more than 50% of the world population and is a well-known cause of peptic ulcer disease. h. pylori has been epidemiologically linked to various other diseases, among which its putative link with certain complex diseases such as type 1 diabetes mellitus (t1dm) is of interest. although antibiotic resistance is a significant clinical problem in h. pylori infection control, the exact cause and much of the underlying mechanisms of t1dm are no ... | 2011 | 21688972 |
| Infectious agents and lymphoma. | In the past 25 years revelations on the genesis of human cancer have come at an increasing pace. Research on oncogenic infectious agents, especially viruses, has helped us to understand the process of malignant transformation of cells because the cellular events in viral-driven transformation mirror, often brilliantly, basic cellular processes that culminate in cancer, even those not associated with viruses. Infectious agents, especially viruses, account for several of the most common malignanci ... | 2011 | 21842703 |
| Diagnosis of Helicobacter pylori Infection. | When an endoscopy is performed, it now becomes easier to observe indirect evidence of the presence of a Helicobacter pylori infection, given the progress of new methods including magnifying narrow band imaging or confocal laser endomicroscopy. Out of the biopsy-based tests, the novel original method proposed concerned culture in a broth medium with or without antibiotics and ELISA detection of H. pylori. New stool antigen tests are still appearing with no major improvement in comparison with the ... | 2011 | 21896080 |
| [clinical and morphological features in a case of recent gastric carcinoma (the signet ring cell carcinoma type)]. | the article presents the case of a male patient, hospitalized due to severe pain in the upper abdomen area, nausea, and vomiting. the patient was diagnosed with surgical acute abdomen, for which emergency surgery is performed. upon penetration into the peritoneal cavity, stomach inspection shows at the medio-gastric level, on the greater curvature, a callous gastric ulcer, with a central perforation. a large excision is decided up to the healthy (normal) gastric tissue, and the resulting pieces ... | 2011 | 21853750 |
| gastric cancer epidemiology in korea. | gastric cancer has been the most commonly diagnosed cancer in korea although the age-standardized mortality and incidence has decreased gradually during last two decades. helicobacter pylori infection and cigarette smoking are well-established risk factors, and the role of dietary factors, such as salted foods, fresh vegetables and fruits, soy foods, and processed or grilled meats on gastric carcinogenesis has been suggested. in this review, we review national and international gastric cancer st ... | 2011 | 22076217 |
| association between gastric mucosal glutathione-s-transferase activity, glutathione-s-transferase gene polymorphisms and helicobacter pylori infection in gastric cancer. | helicobacter pylori infection, though common, leads to gastric cancer (gc) in less than 1% individuals, suggesting the role of host factors. we previously reported the role of glutathione-s-transferase (gst) polymorphisms, the gene encoding a carcinogen-detoxifying enzyme, in gc. this study was aimed to evaluate gst enzyme activity, gst polymorphism, glutathione (gsh) levels and h. pylori in patients with gc. | 2011 | 22139978 |
| Interactions between CagA and smoking in gastric cancer. | To examine the interactions between cytotoxin-associated gene (CagA) positive Helicobacter pylori infection and smoking in non-cardiac gastric cancer. | 2011 | 21876621 |
| are helicobacter pylori and other helicobacter species infection associated with human biliary lithiasis? a meta-analysis. | background: since the isolation of helicobacter species in biliary system, a hypothetical question was raised about the role of these agents in the development of cholelithiasis. this meta-analysis is to explore the association between the helicobacter infection and biliary lithiasis. methodology/principal findings: a systematic literature search was performed to identify all eligible articles. meta-analysis which was carried out using odds ratio and random effect model, 95% confidence intervals ... | 2011 | 22087306 |
| insulin resistance and metabolic syndrome: is helicobacter pylori criminal? | insulin resistance and metabolic syndrome are contributors to atherosclerosis and coronary heart disease. insulin resistance is also responsible in pathogenesis of type ii diabetes. several studies previously evaluated the role of h. pylori infection in coronary heart disease and type ii diabetes. recently published data have described the association between h. pylori infection with insulin resistance and metabolic syndrome. however, this is still a controversial subject. here in, we reviewed c ... | 2011 | 22105726 |
| Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. | The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer. The molecular mechanisms of H. pylori-associated gastric carcinogenesis remain ill defined. In this study, we examined the possibility that H. pylori directly compromises the genomic integrity of its host cells. We provide evidence that the infection introduces DNA double-strand breaks (DSBs) in primary and transformed murine and human epit ... | 2011 | 21896770 |
| Comparative proteome analysis of Helicobacter pylori clinical strains by two-dimensional gel electrophoresis. | To investigate the pathogenic properties of Helicobacter pylori by comparing the proteome map of H. pylori clinical strains. | 2011 | 21960345 |
| [The effects of pronase on drugs concentrations for treatment of Helicobacter pylori infection in gastric tissue]. | To evaluate the effect of pronase on amoxicillin and metronidazole concentrations in gastric tissue. | 2011 | 22041275 |
| Polymorphism in pre-miR-30c contributes to gastric cancer risk in a Chinese population. | To explore the association between single nucleotide polymorphisms (SNPs) A/G in pre-miR-30c and gastric cancer risk and to assess various genotypes that affected the survival of patients, we performed a hospital-based, case-control study in Inner Mongolia autonomous region of China. A total of 240 gastric cancer patients and 240 age- and sex-matched cancer-free controls collected from 2006 to 2011 were enrolled in this study. Polymorphism rs928508 in pre-miR-30c was analyzed by TaqMan SNP genot ... | 2011 | 22108846 |
| Two important criteria for reducing the risk of postoperative ulcers at the gastrojejunostomy site after gastric bypass: patient compliance and type of gastric bypass. | Ulcers at the gastrojejunostomy site are a common problem after gastric surgery. Their postoperative development seems to be associated with Helicobacter pylori-related gastritis or abuse of nicotine, alcohol or non-steroidal anti-inflammatory drugs (NSAIDs), but is also dependent on the choice of surgical method (Roux-en-Y or B-II gastric bypass). | 2011 | 22027289 |
| Anti-infective properties of the melanin-glucan complex obtained from medicinal tinder bracket mushroom, Fomes fomentarius (L.: Fr.) Fr. (Aphyllophoromycetideae). | The goal of this investigation was to comparatively study the efficiency of traditionally used anti-infective drugs and biopolymer complexes originated from the medicinal mushroom Fomes fomentarius (L.:Fr.) Fr.: 1) water-soluble melanin-glucan complex (MGC; -80% melanins and -20% beta-glucans) and 2) insoluble chitin-glucan-melanin complex (ChGMC; -70% chitin, -20% beta-glucans, and -10% melanins). Infectious materials (Helicobacter pylori, Candida albicans, and Herpes vulgaris I and HIV-1(zmb) ... | 2011 | 22135899 |
| Multifaceted SlyD from Helicobacter pylori: implication in [NiFe] hydrogenase maturation. | SlyD belongs to the FK506-binding protein (FKBP) family with both peptidylprolyl isomerase (PPIase) and chaperone activities, and is considered to be a ubiquitous cytosolic protein-folding facilitator in bacteria. It possesses a histidine- and cysteine-rich C-terminus binding to selected divalent metal ions (e.g., Ni(2+), Zn(2+)), which is important for its involvement in the maturation processes of metalloenzymes. We have determined the solution structure of C-terminus-truncated SlyD from Helic ... | 2011 | 22045417 |
| DPO multiplex PCR as an alternative to culture and susceptibility testing to detect Helicobacter pylori and its resistance to clarithromycin. | Macrolide resistance in Helicobacter pylori is the major risk factor for treatment failure when using a proton pump inhibitor-clarithromycin containing therapy. Macrolide resistance is due to a few mutations on the 23S ribomosal subunit encoded by the 23S rRNA gene. The present study aimed at investigating the performance of the dual priming oligonucleotide (DPO)-PCR kit named Seeplex® ClaR-H. pylori ACE detection designed to detect H. pylori and two types of point mutations causing clarithromyc ... | 2011 | 22004003 |
| Protein glycosylation in Helicobacter pylori: beyond the flagellins? | Glycosylation of flagellins by pseudaminic acid is required for virulence in Helicobacter pylori. We demonstrate that, in H. pylori, glycosylation extends to proteins other than flagellins and to sugars other than pseudaminic acid. Several candidate glycoproteins distinct from the flagellins were detected via ProQ-emerald staining and DIG- or biotin- hydrazide labeling of the soluble and outer membrane fractions of wild-type H. pylori, suggesting that protein glycosylation is not limited to the ... | 2011 | 21984942 |
| primary clarithromycin resistance in helicobacter pylori: the multicentric italian clarithromycin resistance observational (micro) study. | primary clarithromycin resistance markedly reduces helicobacter pylori eradication rate following standard therapies. prevalence of primary clarithromycin resistance in h. pylori is increasing, and three point mutations are mainly involved. aim. to assess both the prevalence of primary clarithromycin resistance in italy, and the distribution of the involved point mutations. | 2011 | 21961089 |
| review article: common misconceptions in the management of helicobacter pylori-associated gastric malt-lymphoma. | helicobacter pylori infection is the main cause of gastric mucosa-associated lymphoid tissue (malt) lymphoma. | 2011 | 21919927 |
| infection and eradication of helicobacter pylorus affecting etiology and curative effect of idiopathic thrombocytopenic purpura: a meta analysis. | the study was aimed to explore the relationship between infection of helicobacter pylorus (h. pylorus) and etiology of idiopathic thrombocytopenic purpura (itp) and evaluate whether h. pylorus eradication can increase platelet count in patients with itp. the data-bases of cqvip, wanfang, tsinghua tongfang, cnki and pubmed were searched, inclusion and exclusion criteria and heterogeneity test were determined. the studies of h. pylorus infection and itp were investigated with fixed effect mode met ... | 2011 | 22040983 |
| Capsaicin-sensitive afferentation represents an indifferent defensive pathway from eradication in patients with H. pylori gastritis. | To study the role of capsaicin-sensitive afferent nerves in Helicobacter pylori (H. pylori) positive chronic gastritis before and after eradication. | 2011 | 22046579 |
| [prevalence of helicobater pylori infection among population of northwestern federal district of russian federation]. | studies of helicobater pylori infection rate among population of north-western federal district including st. petersburg in 2007 - 2009. | 2011 | 21913398 |
| second-line levofloxacin-based triple therapy's efficiency for helicobacter pylori eradication in patients with peptic ulcer. | first-line standard eradication efficacy with lansoprazole, amoxicillin and clarithromycin regressed over 10 years. the aim of this study was to evaluate the efficacy and tolerability of a levofloxacin-based regimen in patients with peptic ulcer after failure of the standard first-line h.pylori eradication therapy in a country with a high rate of infection. | 2011 | 21886067 |
| The presence of Helicobacter Pylori in dental plaque of children and their parents: is it related to their periodontal status and oral hygiene? | To investigate the possible presence of H. pylori in subgingival dental plaque of children with upper gastrointestinal symptoms, as well as of their parents' and to detect any association between the presence of H. pylori and oral hygiene together with the periodontal status of children and their parents. | 2011 | 22185245 |
| Helicobacter pylori oipA genetic diversity and its associations with both disease and cagA, vacA s, m, and i alleles among Bulgarian patients. | Prevalence of outer inflammatory protein (oipA) gene functional status in Helicobacter pylori strains from Southeastern Europe is still unclear. H. pylori strains from 70 symptomatic patients were polymerase chain reaction (PCR) assessed for cagA and vacA types, and oipA gene functional status was evaluated by PCR and sequencing. Our results demonstrated a high prevalence of strains with oipA status "on" genes (81%) and strong association between them and peptic ulcers, cagA, and vacA s1 and s1/ ... | 2011 | 21937185 |
| Helicobacter pylori infection and the risk for cardiovascular disease. | 2011 | 22075304 | |
| Long-term clinical outcome of gastric MALT lymphoma after eradication of Helicobacter pylori: a multicentre cohort follow-up study of 420 patients in Japan. | ObjectiveA multicentre cohort follow-up study of a large number of patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma was conducted to elucidate the long-term outcome of the disease after Helicobacter pylori eradication.Methods420 patients with gastric low-grade MALT lymphoma who had undergone successful H pylori eradication and been followed up for at least 3 years were registered from 21 participating institutes. Responders to treatment were defined as patients whose post- ... | 2011 | 21890816 |
| Carcinogenesis, prevention and early detection of gastric cancer: Where we are and where we should go. | Helicobacter pylori is the most common cause of gastric cancer (GC), though smoking, alcohol, diet, genetics and epigenetic factors may also have a role in the occurrence of the disease. Why H. pylori cause GC in only a minority of those infected remains unknown. Although mechanisms of H. pylori-induced carcinogenesis are not yet well understood, several genotypes of H. pylori have been associated with strain virulence and disease risk. Primary prevention of GC should be addressed by avoiding ex ... | 2011 | 21918974 |
| Peptic ulcer disease. | Peptic ulcer disease (PUD) is due mostly to the widespread use of low-dose aspirin and nonsteroidal anti-inflammator drugs. It occurs mostly in older patients and those with comorbidities. Pain awakening the patient from sleep between 12 and 3 a.m. affects two-thirds of duodenal ulcer patients and one-third of gastric ulcer patients. Older adults (>80 years old) with PUD often do not present with abdominal pain; instead, epigastric pain, nausea and vomiting are among their most common presenting ... | 2011 | 21872087 |
| association of human papilloma virus with pterygia and ocular-surface squamous neoplasia. | there are more microorganisms that colonize the human body than resident cells; some are commensal whereas others are pathogenic. pathogenic microorganisms are sensed by the innate or adaptive immune system, an immune response is initiated, and the infection is often cleared. some microorganisms have developed strategies to evade immune defenses, ensuring their long-term survival with potentially devastating consequences for the host. approximately 18% of all cancers can be attributed to infecti ... | 2011 | 22134594 |
| Exploiting bacterial glycosylation machineries for the synthesis of a Lewis antigen-containing glycoprotein. | Glycoproteins constitute a class of compounds of increasing importance for pharmaceutical applications. The manipulation of bacterial protein glycosylation systems from Gram-negative bacteria for the synthesis of recombinant glycoproteins is a promising alternative to the current production methods. Proteins carrying Lewis antigens have been shown to have potential applications for the treatment of diverse autoimmune diseases. In this work, we developed a mixed approach consisting of in vivo and ... | 2011 | 21878645 |
| High frequency of A2143G mutation in clarithromycin-resistant Helicobacter pylori isolates recovered from dyspeptic patients in Iran. | Resistance to clarithromycin in H. pylori isolates is accepted as a main cause of treatment failure in developing countries. We aimed to determine the prevalence of clarithromycin-resistant strains isolated from dyspeptic patients in northern Iran, furthermore we aimed to assess the relationship between clinical outcomes of infection with point mutations. | 2011 | 22064338 |
| Comparative Genomics of Helicobacter pylori and the human-derived Helicobacter bizzozeronii CIII-1 strain reveal the molecular basis of the zoonotic nature of non-pylori gastric Helicobacter infections in humans. | ABSTRACT: | 2011 | 22039924 |
| IL-10, TNF-a and IFN-? Levels in Serum and Stomach Mucosa of Helicobacter Pylori-Infected Patients. | H. pylori is a human pathogen that colonizes the epithelium of the stomach. The host immune response may influence the disease process, where cytokines play important roles in the development of disease. In this study, the concentrations of selected cytokines in the gastric antrum and stomach body mucosa and also in the serum were evaluated. Eighty patients according to their rapid urease test were divided into two groups: H. pylori positive (n=39) and H. pylori-negative (n=41). The concentratio ... | 2011 | 22184269 |
| Contribution of gut microbiota to colonic and extracolonic cancer development. | It is estimated that 20% of malignancies worldwide can be attributed to infections, i.e. about 1.2 million cases per year. A typical example of the association between bacterial infection and gastrointestinal malignancies is Helicobacter pylori infection with both gastric cancer and mucosa-associated lymphoid tissue lymphoma. Bacteria are an important component of the human body. The human intestine contains >500 different types of microorganisms, the 'gut microbiota', that play important functi ... | 2011 | 22179211 |
| cationic amino acid transporter 2 enhances innate immunity during helicobacter pylori infection. | once acquired, helicobacter pylori infection is lifelong due to an inadequate innate and adaptive immune response. our previous studies indicate that interactions among the various pathways of arginine metabolism in the host are critical determinants of outcomes following infection. cationic amino acid transporter 2 (cat2) is essential for transport of l-arginine (l-arg) into monocytic immune cells during h. pylori infection. once within the cell, this amino acid is utilized by opposing pathways ... | 2011 | 22194986 |
| investigating helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture. | the aim of this study was to identify the presence of helicobacter pylori in nasal polyp specimens of patients with nasal polyposis. a cross-sectional study with control group was performed on fresh tissue samples from 25 patients with nasal polyps, and 25 persons with concha bollusa (control group). patients with symptoms of gastroesophageal reflux (gerd) were not enrolled. samples were studied by three methods: polymerase chain reaction (pcr), culture, and urease test. all the diagnostic tests ... | 2011 | 22116383 |
| helicobacter pylori infection, chronic atrophic gastritis and major cardiovascular events: a population-based cohort study. | there is debate whether infection with helicobacter (h.) pylori, the main inducer of chronic atrophic gastritis (cag), is a risk factor for cardiovascular disease and premature mortality. | 2011 | 22189198 |
| [characteristics of duodenogastric reflux in duodenal ulcer patients and its dynamics after helicobacter pylori eradication]. | studying role of duodenogastric reflux (dgr) in pathogenesis and sanogenesis of duodenal ulcer (du). | 2011 | 21916229 |
| Relationship between Helicobacter pylori and Histological Changes in the Gastric Remnant after Subtotal Gastrectomy. | Objective: The aim of this study was to clarify the influence of histological changes in the gastric remnant on Helicobacter pylori (H. pylori) infection after distal gastrectomy (DG) and proximal gastrectomy (PG). Methods: In total, 101 patients who underwent DG (n = 76) or PG (n = 25) for gastric cancer were included in the study. Three biopsy specimens from the remnant stomach were obtained during upper gastrointestinal endoscopy. Each specimen was scored according to the updated Sydney syste ... | 2011 | 22167498 |
| Association between Helicobacter pylori cagA-related genes and clinical outcomes in Colombia and Japan. | ABSTRACT: BACKGROUND: Specific genotypes of several virulence factors of Helicobacter pylori (eg, cagA-positive, vacA s1, oipA "on" and babA-positive) have been reported to be predictors of severe clinical outcomes. Importantly, the presence of these genotypes correlates with each other. We hypothesized that novel virulence genes correlate with the presence of cagA. Therefore, we aimed to find novel candidate virulence genes that correlate with cagA and examined the association of these gene ... | 2011 | 22189161 |
| Communicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011. | To establish strategic priorities for the German national public health institute (RKI) and guide the institute's mid-term strategic decisions, we prioritized infectious pathogens in accordance with their importance for national surveillance and epidemiological research. | 2011 | 21991334 |
| Ultrastructure of the H. pylori microbe in individuals having macrocytosis and B12 deficiency. | The incidence of Helicobacter pylori gastritis is high in India and the number of individuals with vitamin B12 deficiency is also large. An association has been found between these two factors. It is necessary to determine whether H. pylori infection may be a factor in the causation of B12 deficiency and whether it is associated with any morphological changes on ultrastructural examination. A cohort-based study has been performed, which includes 505 young asymptomatic males. These cases have bee ... | 2011 | 21867407 |
| dietary vitamin a intake and incidence of gastric cancer in a general japanese population: the hisayama study. | background: the results of prospective studies examining the association between dietary vitamin a intake and the risk of gastric cancer have often been conflicting. the objective of this study was to investigate this issue in a general japanese population. methods: a total of 2,467 community-dwelling japanese subjects aged 40 years or older were followed up prospectively for 14 years. dietary vitamin a intake wa ... | 2011 | 21948483 |
| guidelines for the management of iron deficiency anaemia. | background iron deficiency anaemia (ida) occurs in 2-5% of adult men and postmenopausal women in the developed world and is a common cause of referral to gastroenterologists. gastrointestinal (gi) blood loss from colonic cancer or gastric cancer, and malabsorption in coeliac disease are the most important causes that need to be sought. defining iron deficiency anaemia the lower limit of the normal range for the laboratory performing the test should be used to define anaemia (b). any level of ana ... | 2011 | 21561874 |
| cd25high tregs and pd-1 expression on gastric infiltrating cd4+ t lymphocytes in patients with helicobacter pylori infection. | we observed by flow cytometry that the frequency of both gastric infiltrating tregs and pd-1 positive cd4 t cells is correlated with the density of h. pylori, suggesting that cellular immunity is inhibited against this pathogen. | 2011 | 21562113 |
| helicobacter pylori cytotoxin-associated gene a (caga) subverts the apoptosis-stimulating protein of p53 (aspp2) tumor suppressor pathway of the host. | type i strains of helicobacter pylori (hp) possess a pathogenicity island, cag, that encodes the effector protein cytotoxin-associated gene a (caga) and a type four secretion system. after translocation into the host cell, caga affects cell shape, increases cell motility, abrogates junctional activity, and promotes an epithelial to mesenchymal transition-like phenotype. transgenic expression of caga enhances gastrointestinal and intestinal carcinomas as well as myeloid and b-cell lymphomas in mi ... | 2011 | 21562218 |
| study on the association of p53 codon 72 polymorphisms with risk of gastric cancer in high incidence hexi area of gansu province in china. | to investigate the possible association of p53 codon 72 arg/pro polymorphisms with risk of gastric cancer in the high incidence hexi area of gansu province in china. blood samples from 140 patients with gastric carcinoma and 125 healthy controls were collected in hexi area of gansu province. polymorphism of p53arg72pro was genotyped by pcr-taqman. for detection helicobacter pylori infection, warhin-starry staining was used. three kinds of polymorphisms of p53arg72pro were arg/arg, arg/pro, pro/p ... | 2011 | 21562767 |
| prevalence of virulent helicobacter pylori strains in patients affected by idiopathic dysrhythmias. | helicobacter pylori virulent strains have been shown to affect cardiovascular diseases through molecular mimicry mechanisms. silent autoimmune myocarditis has been hypothesized to be the cause of idiopathic dysrhythmias (ia). the aim of this study is to assess the prevalence of virulent h. pylori strains in patients affected by ia. in this study,54 patients (40 men, mean age 44 ± 17 years) affected by ia and 50 healthy subjects (34 men, mean age 45 ± 9) were evaluated. ia, defined as dysrhythmia ... | 2011 | 21562783 |
| antibodies against helicobacter pylori heat shock protein 60 aggravate hsp60-mediated proinflammatory responses. | anti-helicobacter pylori heat shock protein 60 (hphsp60) antibodies are usually found in h. pylori-infected patients and are known to be associated with the progression of gastric diseases. however, the effects of these antibodies on the functions of hphsp60 have not been identified. this study aims to investigate the effects of the interaction between anti-hsp60 antibodies and hphsp60 on inflammatory responses. anti-hphsp60 polyclonal sera and monoclonal antibodies (mabs) were produced to evalu ... | 2011 | 21565524 |
| 17{beta}-estradiol suppresses helicobacter pylori-induced gastric pathology in male hypergastrinemic ins-gas mice. | helicobacter pylori-associated gastric cancer is male-predominant and animal studies suggest sex hormones influence gastric carcinogenesis. we investigated the effects of 17β-estradiol (e2) or castration on h. pylori-induced gastritis in male ins-gas/fvb/n (tg(ins1-gas)1sbr) mice. comparisons were made to previously evaluated sham (n=8) and h. pylori infected (n=8), intact male ins-gas mice which had developed severe corpus gastritis accompanied by atrophy, hyperplasia, intestinal metaplasia and ... | 2011 | 21565825 |
| effects of different types of helicobacter pylori on the gap junction intercellular communication in ges-1 cells. | objective to determine the effect of different types of helicobacter pylori (h.pylori) on the gap junction intercellular communication (gjic) in ges-1 cells, and investigate the types of h.pylori related to the dysfunction of gjic. methods different types of h.pylori clinical strains were isolated and cultured, including the east asian caga(-)positive h.pylori (east asian caga(+)h.pylori), western caga(-)positive h.pylori (western caga(+)h.pylori), and the caga(-)negative h.pylori (caga(-)h.pylo ... | 2011 | 21566279 |
| influence of sociodemographic factors on helicobacter pylori prevalence variability among schoolchildren in leipzig, germany. a long-term follow-up study. | until the beginning of this decade the assumption was that the helicobacter pylori prevalence increases with the age of the population under consideration. more and more epidemiological studies have been suggestive of constancy in helicobacter pylori prevalence, but to date there has been no long-term follow-up study in a large group of children confirming this hypothesis. | 2011 | 21526656 |
| crystal structure and biophysical characterisation of helicobacter pylori phosphopantetheine adenylyltransferase. | helicobacter pylori is a bacterium that causes chronic active gastritis and peptic ulcers. drugs targeting h. pylori phosphopantetheine adenylyltransferase (hpppat), which is involved in coa biosynthesis, may be useful. herein, we report the expression in escherichia coli and purification of recombinant hpppat and describe a crystal structure for an hpppat/coa complex. as is the case for e. coli ppat (ecppat), hpppat is hexameric in solution and as a crystal. each protomer has a well-packed dinu ... | 2011 | 21527250 |
| autoimmune bullous diseases the spectrum of infectious agent antibodies and review of the literature. | pemphigus and bullous pemphigoid are two autoimmune diseases that have a similar pathogenesis. both have a genetic predisposition which promotes the production of auto-antibodies targeted against different components of the epidermal desmosome and hemidesmosome. environmental factors play an important role in the pathogenesis of this autoimmune disease. among these, the role of infectious agents was debated as a causative factor. we sought to determine a possible connection between various infec ... | 2011 | 21527361 |
| tumor-associated macrophages as major source of april in gastric malt lymphoma. | lymphoid hyperplasia of gastric mucosa associated with helicobacter pylori (hp) infection represents a pre-neoplastic condition of the mucosa associated lymphoid tissue (malt) which may evolve to a b cell lymphoma. while it is well established that the initial neoplastic proliferation of b cells is antigen-driven and dependent on the helper activity of hp-specific t cells, it needs to be elucidated which cytokine or soluble factor(s) promote b cell activation and lymphomagenesis. herein, we orig ... | 2011 | 21527528 |
| eosinophilic gastroenteritis: clinical manifestations and morphological characteristics, a retrospective study of 42 patients. | abstract objective. to evaluate the clinical manifestations, endoscopic, and radiological characteristics, histological features, and treatment of eosinophilic gastroenteritis in adult patients. methods. the clinical records of 34 patients diagnosed as eosinophilic gastroenteritis and eight patients who had abdominal symptoms and unexplained peripheral eosinophilia but no evidence of tissue eosinophilic infiltration were reviewed and analyzed. results. thirteen patients had a history of asthma o ... | 2011 | 21623674 |
| a mechanism for the action of the compound da-6034 on nf-κb pathway activation in h. pylori-infected gastric epithelial cells. | da-6034 is a synthetic derivative of eupatilin, a flavonid with anti-inflammatory effects. the aim of this study was to investigate the effects of da-6034 on the interactions between iκb kinase (ikk) and heat shock protein 90 (hsp90) and activation of the nf-κb signaling pathway in human gastric epithelial cells infected with h. pylori. mkn-45 gastric epithelial cell line was treated with da-6034 and h. pylori. da-6034 significantly inhibited nf-κb activation and upregulated the expressions of n ... | 2011 | 21623862 |
| quantitation of helicobacter pylori urec gene and its comparison with different diagnostic techniques and gastric histopathology. | numerous diagnostic assays for helicobacter pylori detection are available. however, these techniques have their own advantages as well as limitations. here we tried to develop a real-time quantitative (q) pcr assay to measure urec copy number to detect h. pylori, based on the fact that there is only one copy of the urec gene per bacterium. we enrolled 120 adult patients [non-ulcer dyspepsia (nud) 60, peptic ulcer disease (pud) 20, gastric cancer (gc) 40] undergoing upper gastrointestinal endosc ... | 2011 | 21624400 |
| real-time pcr improves helicobacter pylori detection in patients with peptic ulcer bleeding. | histological and rapid urease tests to detect h. pylori in biopsy specimens obtained during peptic ulcer bleeding episodes (pub) often produce false-negative results. we aimed to examine whether immunohistochemistry and real-time pcr can improve the sensitivity of these biopsies. | 2011 | 21625499 |
| helicobacter pylori: is it a complete villain? | 2011 | 21626119 | |
| a c to t polymorphism of urokinase plasminogen activator (p141l) is associated with helicobacter pylori infection. | urokinase plasminogen activator (upa) plays an important role in tumor invasion and certain inflammatory diseases. however, few studies have paid attention to how the upa is associated with helicobacter pylori infection and gastric atrophy. this study investigated associations of a c-to-t polymorphism of upa (p141l, rs2227564) in exon 6 in 454 japanese health checkup examinees (126 males and 328 females) aged 35 to 85 without a history of cancer. the upa was genotyped by polymerase chain reactio ... | 2011 | 21627387 |
| sequential therapy versus standard triple drug therapy for eradication of helicobacter pylori in patients with perforated duodenal ulcer following simple closure. | abstract background. resistance to clarithromycin, a component of standard triple therapy, leads to inconsistent eradication rates of helicobacter pylori infection. some studies have shown higher eradication rates for h. pylori using sequential regimen. this study was done to compare the eradication rates for h. pylori infection between the standard triple drug therapy and the sequential therapy. methods. seventy-three patients with perforated duodenal ulcer following simple closure with h. pylo ... | 2011 | 21627398 |
| the occupational risk of helicobacter pylori infection among gastroenterologists and their assistants. | abstract: background: helicobacter pylori is a widely spread bacterium that mainly inhabits the gastric mucosa and can lead to serious illnesses such as peptic ulcer disease, gastric carcinoma and gastric malt lymphoma. the oral-oral route seems to be the main transmission route. the fact that endoscopes are contaminated after being used to perform a gastroscopy leads one to question whether gastroenterologists and endoscopy nurses and assistants run a higher risk of infection. methods: a system ... | 2011 | 21627778 |
| inverse correlation between allergy markers and helicobacter pylori infection in children is associated with elevated levels of tgf-β | objectives: we evaluated allergy/hypersensitivity clinical markers and their correlation with helicobactor pylori infection in children and adults to analyze how early acquisition of h. pylori could modulate allergic disorder expression. patients and methods: h. pylori presence was assessed by the rapid urease test and histology of antrum biopsies in 165 patients. skin tests, serum ige, and two clinical allergy questionnaires were performed. allergy severity was operationally defined using a com ... | 2011 | 21629122 |
| helicobacter pylori infection in various groups of patients studied, estimated by 14c-urea breath test. | the aim of this study was the detection of helicobacter pylori (hp) infection and estimation of the clinical validity and the accuracy of the 14c-urea breath test in the groups of patients studied. a total of 248 patients with gastric diseases were examined. there were 38 patients with gastric ulcer, 41 with duodenal ulcer, 43 with gastroduodenitis erosiva, 26 with hiatus hernia, 36 with gastric carcinoma and 64 patients with gastritis. there were 103 true positive (tp), 139 true negative (tn), ... | 2011 | 21630553 |
| metal binding ability of cysteine-rich peptide domain of zip13 zn(2+) ions transporter. | the coordination modes and thermodynamic stabilities of the complexes of the cysteine-rich n-terminal domain fragment of the zip13 zinc transporter (mpgcpcpgcg-nh(2)) with zn(2+), cd(2+), bi(3+), and ni(2+) have been studied by potentiometric, mass spectrometric, nmr, cd, and uv-vis spectroscopic methods. all of the studied metals had similar binding modes, with the three thiol sulfurs of cysteine residues involved in metal ion coordination. the stability of the complexes formed in solution chan ... | 2011 | 21630642 |
| aberrant cpg island hypermethylation in pediatric gastric mucosa in association with helicobacter pylori infection. | abstract context.- helicobacter pylori infection is primarily acquired during childhood and persists throughout life in the absence of eradication with antibiotics. helicobacter pylori infection induces methylation in the promoter cpg island loci in gastric epithelial cells. thus, aberrant cpg island hypermethylation in gastric epithelial cells likely occurs early in life, although there are no existing data supporting this notion. objectives.-to identify whether aberrant cpg island hypermethyla ... | 2011 | 21631269 |
| ifn-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by helicobacter suis infection. | in this study, we aimed to assess the role of helper t cells in the development of gastric lymphoid follicles induced by helicobacter (h). suis infection. c57bl/6j mice were orally inoculated with h. suis. six weeks after infection, gastric lymphoid follicles were observed in the gastric mucosa by hematoxylin and eosin staining, and the number of follicles was increased throughout the infection period. an immunohistological examination showed that the lymphoid follicles were composed of b cells, ... | 2011 | 21631601 |
| empirical modified sequential therapy containing levofloxacin and high-dose esomeprazole in second-line therapy for helicobacter pylori infection: a multicentre clinical trial. | objectives sequential therapy appears to achieve a higher helicobacter pylori eradication rate than triple therapy. we assessed the efficacy and tolerability of modified sequential therapy containing levofloxacin and high-dose esomeprazole in second-line therapy. methods patients who failed first-line triple therapy with clarithromycin, amoxicillin and a proton pump inhibitor were eligible in this multicentre trial. eligible patients were treated with esomeprazole 40 mg and amoxicillin 1 g for t ... | 2011 | 21632579 |
| asymmetric dimethylarginine: a novel biomarker of gastric mucosal injury? | nitric oxide (no), a multifunctional endogenous gas molecule, is metabolized from l-arginine by enzymatic reaction in the presence of nitric oxide synthase. no, an important gas signaling molecule, is a gastric mucosa protective factor that contributes significantly to maintain normal gastric mucosa integrity. no increases gastric mucosa blood flow, regulates the secretion of mucus and bicarbonate, and inhibits the secretion of gastric juice. asymmetric dimethylarginine (adma) has been identifie ... | 2011 | 21633526 |
| crystal structure and enzymatic characterization of thymidylate synthase x (thyx) from helicobacter pylori strain ss1. | thymidylate synthase x (thyx) catalyzes the methylation of dump to form dtmp in bacterial life cycle and is regarded as a promising target for antibiotics discovery. helicobacter pylori is a human pathogen associated with a number of human diseases. here we cloned and purified the thyx enzyme from h. pylori ss1 strain (hpthyx). the recombinant hpthyx was discovered to exhibit the maximum activity at ph 8.5, and k(m) values of the two substrates dump and ch(2) h(4) folate were determined to be 15 ... | 2011 | 21633987 |
| importance of vacas1 gene in gastric cancer patients infected with caga-negative helicobacter pylori. | 2011 | 21635556 | |
| retraction: nf-kappab activation by helicobacter pylori requires akt-mediated phosphorylation of p65. | abstract: retraction after lengthy investigation by the editors, the original article [1] has been retracted because of inappropriate duplication of images from previously published articles. the last author, naoki mori takes full responsibility and apologizes for any inconvenience caused. references 1. takeshima e, tomimori k, kawakami h, ishikawa c, sawada s, tomita m, senba m, kinjo f, minuro h, sasakawa c, fujita j, mori n: nf-kappab activation by helicobacter pylori requires akt-mediated ph ... | 2011 | 21635758 |
| crystallization and preliminary crystallographic studies of helicobacter pylori arginase. | helicobacter pylori arginase is an important factor in evasion of the host's immune system and contributes to persistent infection by this bacterium. it is unique in many aspects compared with other arginases: for example, it has optimal activity with co(2+) as a cofactor rather than mn(2+) and has strongest activity at acidic ph instead of alkaline ph. in this study, h. pylori arginase was purified and crystallized in complex with mn(2+) and a diffraction data set was collected to 2.2 å resolut ... | 2011 | 21636918 |