Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| prevalence, distribution and correlates of endocervical human papillomavirus types in brazilian women. | we determined the prevalence, distribution and correlates of human papillomavirus (hpv) types in 386 mixed-income, sexually active women in são paulo, brazil. endocervical samples were tested for hpv dna with l1 primers my09 and my11; negative and indeterminate samples were retested using gp 5+/6+ consensus primers. hpv was detected in 35% of all women; high-risk/probable high-risk types in 20%; low-risk types in 7%; and an indeterminate type in 10%. twenty-five hpv types were found overall: 17 ... | 2010 | 20089995 |
| protein p 16ink4a expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix. | the association of human papilloma virus (hpv) infection and cervical intraepithelial neoplasia (cin) is well recognized. interaction of hpv oncogenic proteins with cellular regulatory proteins leads to up regulation of p16 ink4a , a cdk inhibitor, which is a biomarker for hpv infection. we investigated p16 expression in cin and invasive squamous cell carcinoma (scc) which has not been reported in the indian population previously. | 2010 | 20090213 |
| relationship of atypical glandular cell cytology, age, and human papillomavirus detection to cervical and endometrial cancer risks. | to quantify the age-specific and reproductive organ-specific cancer risk after an atypical glandular cell (agc) cytologic interpretation in large clinic-based sample in which routine high-risk human papillomavirus (hpv) testing is conducted. | 2010 | 20093895 |
| surgical treatment of epidermodysplasia verruciformis. | epidermodysplasia verruciformis (ev) is a genodermatosis, characterized by human papilloma virus infection, with polymorphic and disseminated lesions that develop malignant transformation in approximately half of patients. | 2010 | 20100263 |
| association of hiv infection with distribution and viral load of hpv types in kenya: a survey with 820 female sex workers. | human papillomavirus (hpv) and hiv are each responsible for a considerable burden of disease. interactions between these infections pose substantial public health challenges, especially where hiv prevalence is high and hpv vaccine coverage low. | 2010 | 20102630 |
| acceptability of human papillomavirus vaccine for males: a review of the literature. | the quadrivalent human papillomavirus virus vaccine was recently licensed for use in males in the united states. this study reviews available published literature on acceptability among parents, health care providers, and young males. among 23 published articles, half were conducted in the united states. the majority (87%) used quantitative survey methodology, and 13% used more explorative qualitative techniques. convenience samples were used in most cases (74%) and 26% relied on nationally repr ... | 2010 | 20113917 |
| immunogenicity and safety of human papillomavirus-16/18 as04-adjuvanted cervical cancer vaccine coadministered with combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine to girls and young women. | many countries recommend human papillomavirus (hpv) vaccination in female adolescents at an age when other vaccines are routinely administered. this open, randomized, multicenter study (108464/nct00426361) evaluated coadministration of hpv-16/18 as04-adjuvanted vaccine with diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine (dtpa-ipv). | 2010 | 20113920 |
| enhanced humoral and cellular immune responses after sublingual immunization against human papillomavirus 16 l1 protein with adjuvants. | needle-free nonparenteral vaccines offer a number of practical advantages, especially in developing countries. to address the effects of vaccine administration route, we tested mucosal and systemic immune responses against human papillomavirus 16 l1(hpv16l1) protein using intranasal, intravaginal, transdermal, sublingual (sl) and intramuscular routes. the sl route provided the most effective mucosal secretory iga (siga) and serum igg responses. after a 150 microg antigen dose via the sl route, s ... | 2010 | 20116467 |
| predictors of parents' willingness to vaccinate for human papillomavirus and physicians' intentions to recommend the vaccine. | the present study examined potential predictors of parents' willingness to vaccinate their children for human papillomavirus (hpv) and physicians' intentions to encourage parents to vaccinate their children, now that the u.s. food and drug administration (fda) has approved a highly effective vaccine. | 2010 | 20123174 |
| epigenetic repression of e-cadherin by human papillomavirus 16 e7 protein. | a common feature shared between several human cancer-associated viruses, such as epstein-barr virus, hepatitis b virus and hepatitis c virus, and human papillomavirus (hpv) is the ability to reduce the expression of cellular e-cadherin. since e-cadherin is used by langerhans cells to move through the stratified epithelium, its reduction may affect the efficiency by which the immune system responds to hpv infection and the length of persistent hpv infections. we observed that the e7 protein of th ... | 2010 | 20123756 |
| [exploring the issue of cervical cancer prevention and control in women living with hiv/aids]. | shared risk factors mean that women engaging in unprotected sex are at risk of contracting both the human immunodeficiency virus (hiv) and the human papillomavirus (hpv). as hiv suppresses bodily immune systems, an hiv-positive woman with hpv will likely see a faster progression of cancer cells around the cervix. therefore, it is important to prevent and control cervical cancer in hiv-positive women. findings from the literature on this topic include: 1) hiv-positive women face a relatively grea ... | 2010 | 20127625 |
| immunotherapy for cervical cancer: research status and clinical potential. | the high-risk types of human papillomavirus (hpv) have been found to be associated with most cervical cancers and play an essential role in the pathogenesis of the disease. despite recent advances in preventive hpv vaccine development, such preventive vaccines are unlikely to reduce the prevalence of hpv infections within the next few years, due to their cost and limited availability in developing countries. furthermore, preventive hpv vaccines may not be capable of treating established hpv infe ... | 2010 | 20199126 |
| prophylactic human papillomavirus vaccines: will they do their job? | the prophylactic hpv l1 virus like particle vaccines are highly efficacious preventing >98% of hpv 16/18 caused high grade cervical intra-epithelial neoplasia (cin2/3) according to protocol group in phase iii randomized clinical trials over approximately 4 years. data from the trials together with postvaccine surveillance indicates that they have a good safety profile. as the current hpv vaccines include only two of the 15 oncogenic hpvs, they will not eliminate cervical cancer or the other hpv ... | 2010 | 20201919 |
| the impact of intolerance of uncertainty on anxiety after receiving an informational intervention about hpv: a randomised controlled study. | this study examined the impact of intolerance of uncertainty (iu) and an informational intervention about human papillomavirus (hpv) infection on perceived uncertainty about one's hpv testing status (referred to as 'hpv uncertainty') and anxiety. iu, hpv uncertainty and other pre-intervention measures were assessed through mailed questionnaires. participants were then randomly assigned to receive either a long (n = 125) or short (n = 124) hpv-specific information pamphlet or a long (n = 131) or ... | 2010 | 20204959 |
| the quality of life of patients with genital warts: a qualitative study. | genital warts, which are caused by infection with human papillomavirus (hpv), are one of the most common sexually transmitted diseases in europe. although genital warts are commonly perceived as a non-serious condition, treatment is often long, of varying effectiveness and the recurrence rate is high. very few studies have been performed on the personal consequences of genital warts. the aim of this qualitative study, set in denmark, was to examine the ways in which genital warts may affect pati ... | 2010 | 20205944 |
| parental acceptance of a mandatory human papillomavirus (hpv) vaccination program. | the objective of this study was to determine factors that influence parent's acceptance of a mandatory school-based human papillomavirus (hpv) vaccination program. | 2010 | 20207933 |
| a c-terminal hydrophobic, solvent-protected core and a flexible n-terminus are potentially required for human papillomavirus 18 e7 protein functionality. | the oncogenic potential of the high-risk human papillomavirus (hpv) relies on the expression of genes specifying the e7 and e6 proteins. to investigate further the variation in oligomeric structure that has been reported for different e7 proteins, an hpv-18 e7 cloned from a hispanic woman with cervical intraepithelial neoplasia was purified to homogeneity most probably as a stable monomeric protein in aqueous solution. we determined that one zinc ion is present per hpv-18 e7 monomer by amino aci ... | 2010 | 20211680 |
| the location of endogenous wild-type p53 protein in 293t and hek293 cells expressing low-risk hpv-6e6 fusion protein with gfp. | the mechanism underlining human papillomaviruses (hpvs) causing cancer has been studied extensively, and it was concluded that the high-risk hpvs' e6 targeted and degraded tumor suppressor protein p53, leading to infected cells malignant transformation. in contrast, the low-risk hpvs only cause proliferative but non-invasive lesions of infected epithelia. therefore, we hypothesized that low-risk hpvs' e6 might interact with p53 in a different pattern. we used a mammalian green fluorescent protei ... | 2010 | 20213049 |
| [human papillomavirus infections in urology]. | 2010 | 20223127 | |
| abnormal anal cytology in hiv-infected women. | the purpose of this study was to assess the prevalence of and risk factors for abnormal anal cytology and human papillomavirus (hpv) infections in women who are human immunodeficiency virus (hiv) positive. | 2010 | 20223443 |
| hpv testing on self collected cervicovaginal lavage specimens as screening method for women who do not attend cervical screening: cohort study. | to determine whether offering self sampling of cervicovaginal material for high risk human papillomavirus (hpv) testing is an effective screening method for women who do not attend regular cervical screening programmes. | 2010 | 20223872 |
| empirically evaluating decision-analytic models. | model-based cost-effectiveness analyses support decision-making. to augment model credibility, evaluation via comparison to independent, empirical studies is recommended. | 2010 | 20230547 |
| model-based estimation of viral transmissibility and infection-induced resistance from the age-dependent prevalence of infection for 14 high-risk types of human papillomavirus. | viral transmissibility and natural resistance to infection are key determinants in assessing the population impact of human papillomavirus (hpv) vaccination, yet information on these parameters is scarce. using data from 2 large-scale surveys on sexual behavior in the netherlands (carried out in 2005-2006), the authors employed a bayesian framework to fit a transmission model to the cross-sectional age-dependent prevalence of hpv dna in cervical smears (data collected in 1992-2002), assuming tha ... | 2010 | 20231211 |
| research on cancer prevention, detection and management in low- and medium-income countries. | the burden of cancer in low- and medium-income countries (lmic) is expected to increase in the next decades. the application of current knowledge and results of research in key areas would contribute to limit the impact of this phenomenon. opportunities for research on cancer prevention in lmic include investigating specific circumstances of exposure to known carcinogens and to agents which are not prevalent in other regions, as well as interactions among carcinogens and between genetic and envi ... | 2010 | 20231304 |
| human papillomavirus dna and oncogene alterations in colorectal tumors. | the aim of the present study is to determine the presence and molecular integrity of high-risk hpv types in colorectal adenocarcinomas and to assess whether viral dna is related to common proto-oncogene alterations, such as k-ras mutations and c-myc gene amplification, in colorectal cancer. seventy-five colorectal adenocarcinomas were screened for hpv infection using nested-pcr (my09/11-gp5+/6+). hpv typing was performed by type-specific pcr for hpv 16 and hpv 18 dna. unidentified samples were s ... | 2010 | 20232185 |
| bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer. | oropharyngeal squamous cell carcinoma (opscc) associated with human papilloma virus (hpv) is rapidly growing in incidence. despite better prognosis than opscc associated with traditional risk factors, treatment failure still occurs in a significant proportion of patients. we had identified the antiapoptotic protein bcl2 as a marker for poor outcome in advanced opscc treated with concurrent chemoradiation. to determine whether bcl2 and hpv together might further characterize treatment response, w ... | 2010 | 20233885 |
| phase ii trial of imiquimod and hpv therapeutic vaccination in patients with vulval intraepithelial neoplasia. | vulval intraepithelial neoplasia (vin) is a premalignant condition, which is frequently associated with type hpv16 infection, and multifocal disease has high rates of surgical treatment failure. | 2010 | 20234368 |
| high-resolution genomic profiling of human papillomavirus-associated vulval neoplasia. | the incidence of human papillomavirus-associated vulval neoplasia is increasing worldwide; yet the associated genetic changes remain poorly understood. | 2010 | 20234371 |
| human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. | basaloid squamous cell carcinoma of the upper aerodigestive tract is a rare, morphologically distinct variant of squamous cell carcinoma that is thought to be clinically aggressive. the histologic features are distinct from, but often confused with, those of human papillomavirus-related oropharyngeal nonkeratinizing squamous cell carcinoma. the role of human papillomavirus as an etiologic agent in true basaloid squamous cell carcinoma is controversial. the purpose of this study was to determine ... | 2010 | 20236687 |
| multiplexed serologic assay for nine anogenital human papillomavirus types. | a multiplexed human papillomavirus (hpv) immunoassay has been developed for the detection of human igg antibodies to hpv type 6, 11, 16, 18, 31, 33, 45, 52, and 58 virus-like particle (vlp) types in serum following natural infection or immunization with vlp-based vaccines. the vlp antigens were covalently conjugated to carboxyl luminex microspheres (ms) using a carbodiimide chemistry. antibody (ab) titers were determined in a direct binding format, in which an igg1- to -4-specific, phycoerythrin ... | 2010 | 20237197 |
| a cancer derived mutation in the retinoblastoma gene with a distinct defect for lxcxe dependent interactions. | the interaction between viral oncoproteins such as simian virus 40 tag, adenovirus e1a, and human papilloma virus e7, and the retinoblastoma protein (prb) occurs through a well characterized peptide sequence, lxcxe, on the viral protein and a well conserved groove in the pocket domain of prb. cellular proteins, such as histone deacetylases, also use this mechanism to interact with the retinoblastoma protein to repress transcription at cell cycle regulated genes. for these reasons this region of ... | 2010 | 20298605 |
| warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. report of 45 cases. | most penile cancers are squamous cell carcinomas, but there are several subtypes with different clinicopathologic, viral, and outcome features. we are presenting 45 cases of a distinctive morphological variant of penile squamous cell carcinoma composed of mixed features of warty and basaloid carcinomas. this tumor was earlier recognized in a recent viral study and showed a high association with human papillomavirus infection. however, clinicopathologic features are not well known. in this multi- ... | 2010 | 20305615 |
| gynecologic infections seen in cervical smears in kuwait. | to study the different gynecologic infections seen in cervical smears in kuwait. | 2010 | 20306988 |
| prevalence and risk profile of cervical human papillomavirus infection in zhejiang province, southeast china: a population-based study. | benign or malignant lesions caused by human papillomavirus (hpv) produce considerable health burden worldwide. since limited cross-protection would be offered between hpv types, heterogeneity in hpv type-specific distribution should be taken into account when predicting the effect of current prophylactic vaccines and forming the basic for the second-generation vaccines targeted to specific regions. here, we investigated the prevalence of cervical hpv infection, as well as predictors concerned, i ... | 2010 | 20307327 |
| human papillomavirus-related disease in men: not just a women's issue. | the most common cause of mortality related to human papillomavirus (hpv) infection is cervical cancer. however, male hpv infection is also an important concern, both for the disease burden in men and for the risk of transmission to women. hpv is associated with a variety of cancers in men, including anal cancer and a subset of penile and oral cancers. the incidence of anal and oral cancers related to hpv is increasing in the general population and is growing even faster among individuals who are ... | 2010 | 20307839 |
| examining the development and sexual behavior of adolescent males. | a careful examination of young men's sexuality by health professionals in pediatrics, primary care, and reproductive health is foundational to adolescent male sexual health and healthy development. through a review of existing published data, this article provides background and a developmental framework for sexual health services for adolescent boys. the article first defines and provides an overview of adolescent boys' sexual health, and then discusses developmentally focused research on the f ... | 2010 | 20307842 |
| cervical cancer prevention: new tools and old barriers. | cervical cancer is the second most common female tumor worldwide, and its incidence is disproportionately high (>80%) in the developing world. in the united states, in which papanicolaou (pap) tests have reduced the annual incidence to approximately 11,000 cervical cancers, >60% of cases are reported to occur in medically underserved populations as part of a complex of diseases linked to poverty, race/ethnicity, and/or health disparities. because carcinogenic human papillomavirus (hpv) infection ... | 2010 | 20310056 |
| comparison of mrna and protein measures of cytokines following vaccination with human papillomavirus-16 l1 virus-like particles. | mrna expression signatures are frequently used as surrogate measures of cellular function and pathway changes. few studies have directly compared results obtained using gene expression and multiplex protein assays for corresponding gene products. | 2010 | 20332253 |
| human papillomavirus genotyping in histological sections of precursor lesions of cervical carcinoma: its role as a possible adjunct for the evaluation of the oncogenic potential of specific human papillomavirus genotypes - a study in a coastal region of southeastern spain. | human papillomavirus (hpv) genotyping is usually performed on cytological specimens with the aim of discerning between high- and low-risk genotypes. | 2010 | 20332645 |
| cd4+foxp3+ regulatory t cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomata acuminata after laser therapy. | condylomata acuminata (ca) caused by human papillomavirus (hpv) is a common sexually transmitted disease with half a million new cases diagnosed in the united states per year and the annual increase in incidence in china. recurrence is a major challenge for ca treatment. recently, we demonstrated that foxp3(+) regulatory t (treg) cells mediate the immunosuppression in large genital warts. here, we further report that low-dose cyclophosphamide (cy), a conventional chemotherapy drug, can effective ... | 2010 | 20338811 |
| oropharyngeal carcinoma related to human papillomavirus. | 2010 | 20339160 | |
| ptch1 gene haplotype association with basal cell carcinoma after transplantation. | basal cell carcinoma (bcc) is 10 times more frequent in organ transplant recipients (otrs) than in the general population. factors in otrs conferring increased susceptibility to bcc include ultraviolet radiation exposure, immunosuppression, viral infections such as human papillomavirus, phototype and genetic predisposition. the ptch1 gene is a negative regulator of the hedgehog pathway, that provides mitogenic signals to basal cells in skin. ptch1 gene mutations cause naevoid bcc syndrome, and c ... | 2010 | 20346027 |
| knowledge, attitudes, and communication around human papillomavirus (hpv) vaccination amongst urban asian mothers and physicians. | to determine why hpv vaccination uptake is low in asia, we surveyed attitudes, knowledge and communication about cervical cancer and hpv vaccination amongst 480 physicians and 1617 randomly selected urban mothers who could afford hpv vaccines in korea, malaysia, taiwan and thailand. hpv vaccine rejection by mothers was linked with poor knowledge and low perceptions of self-relevance. physicians' likelihood of raising the subject and/or recommending vaccination was linked to how proactively they ... | 2010 | 20347631 |
| the significance of hpv in the follow-up period after treatment for cin. | high-risk anogenital human papillomavirus (hpv) infections are causally related to cervical cancer. successful treatment of cervical intraepithelial neoplasia (cin) results in complete eradication of hpv in most cases. there is an increasing interest regarding the role of hpv testing in the follow-up period after treatment for cin. | 2010 | 20349777 |
| content analysis of continuing medical education for cervical cancer screening. | since 2003, newer cervical cancer screening guidelines that include human papillomavirus (hpv) testing with cytology (hpv co-testing) call for extension of screening intervals in women who are cytology normal and hpv negative. continuing medical education (cme) may help increase knowledge and appropriate adoption of new technologies and guidelines. however, there are concerns that industry support of cme may bias messages favoring newer technologies without emphasizing the updated guidelines, es ... | 2010 | 20350199 |
| human papillomavirus vaccine project stirs controversy in india. | 2010 | 20351085 | |
| a population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia. | human papillomavirus (hpv) types differ profoundly in cervical carcinogenicity. for the most carcinogenic type hpv16, variant lineages representing further evolutionary divergence also differ in cancer risk. variants of the remaining 10 to 15 carcinogenic hpv types have not been well studied. in the first prospective, population-based study of hpv variants, we explored whether, on average, the oldest evolutionary branches within each carcinogenic type predicted different risks of >2-year viral p ... | 2010 | 20354192 |
| perceived uncertainty, coping strategies, and adaptation in women with human papillomavirus on pap smear. | to explore, identify, and describe the perception of uncertainty over time in college-aged women experiencing the unexpected event of an abnormal pap smear with human papillomavirus (hpv). | 2010 | 20354414 |
| assessment of the perceptions and administration of the human papillomavirus vaccine. | to investigate practitioner acceptability of the recommendation to offer the human papillomavirus (hpv) vaccine to adolescent women. | 2010 | 20354417 |
| re: age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting. | 2010 | 20360534 | |
| adult male circumcision: will it reduce disease caused by human papillomavirus? | 2010 | 20370482 | |
| metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory t lymphocytes and inhibiting tumor angiogenesis. | although cancer vaccines are emerging as innovative methods for cancer treatment, these alone have limited potential for treating measurable tumor burden. thus, the importance of identifying anticancer strategies with greater potency is necessary. the chimeric dna vaccine ctgf/e7 (connective tissue growth factor linked to the tumor antigen human papillomavirus 16 e7) generates potent e7-specific immunity and antitumor effects. we tested immune-modulating doses of chemotherapy in combination with ... | 2010 | 20372107 |
| our knowledge of human papillomavirus (hpv), and its role in the genesis of cervical cancer, continues to grow. | 2010 | 20374606 | |
| cigarette smoking linked to increased human papillomavirus dna load. | 2010 | 20375321 | |
| molecular variants of hpv type 16 e6 among honduran women. | in this study, we investigated the prevalence of human papillomavirus 16 (hpv-16) variants in honduran women with normal cytology and with dysplasia and cervical cancer. | 2010 | 20375791 |
| conjunctival squamous cell carcinoma due to ocular prostheses: a case report and review of literature. | conjunctival squamous cell carcinoma (scc) is a rare finding in everyday clinical practice, but is the most common malignancy of the ocular surface. the incidence of this malignancy in the united states is 0.03 per 100,000 persons. it is one extreme of a spectrum of lesions encompassed in ocular surface squamous neoplasia which range from dysplasia to carcinoma in situ to invasive scc. exposure to ultraviolet radiation b (uvb), human papilloma virus (hpv), and human immunodeficiency virus (hiv) ... | 2010 | 20376710 |
| morphine-sparing effect by cox-1 inhibitor sustains analgesic function without compromising antigen-specific immunity and antitumor effect of naked dna vaccine. | morphine and ketorolac, two analgesics with different mechanisms, have been widely used in controlling cancer pain and postoperative pain in surgery. our previous study revealed that morphine could suppress the anti-tumor effect of antigen-specific dna vaccine. in this study, we further evaluated and compared another analgesic drug, ketorolac, with morphine for its analgesic functions and the antitumor immunities of antigen-specific dna vaccine. we first observed that ketorolac-treated mice did ... | 2010 | 20377998 |
| the sociocultural context of gynecological health among haitian immigrant women in florida: applying ethnographic methods to public health inquiry. | twalet deba, a culturally mediated feminine hygiene practice, is widespread in little haiti, the predominately haitian neighborhood in miami, florida. this practice may have important implications for susceptibility to sexually transmitted infections, including human papillomavirus, the principal cause of cervical cancer. previous research has not examined the full context of twalet deba in consideration of cultural beliefs and norms about women's hygiene and sexual health. | 2010 | 20379893 |
| cancer prevention: major initiatives and looking into the future. | cancer is one of the major causes of death in countries across the world. however, at least half of cancers could be prevented. this article reviews the relationship between cancer incidence and the major risk factors: tobacco use, exposure to infections, nutrition, obesity and physical activity. several major current cancer prevention initiatives are presented, including the effort for global tobacco control, vaccination programs for human papilloma virus, chemoprevention, and cohort studies to ... | 2010 | 20384561 |
| passport to promiscuity or lifesaver: press coverage of hpv vaccination and risky sexual behavior. | a significant minority of parents are concerned about adolescents engaging in risky sexual behavior following human papillomavirus (hpv) vaccination. the way the hpv vaccine is reported in the media has the potential to influence public understanding and vaccination decisions. the present study examined the content of articles published between 2003 and 2008 in british national newspapers that addressed the issue of adolescents engaging in risky sexual behavior following hpv vaccination. we used ... | 2010 | 20390987 |
| distribution of human papillomavirus types in women from valencia, spain, with abnormal cytology. | to determine human papillomavirus (hpv) types among cervical smears using polymerase chain reaction (pcr) and to contribute to the knowledge of human papillomavirus genotype distribution and prevalence of oncogenic types in cervical lesions in spain. | 2010 | 20391971 |
| association of schistosoma haematobium and human papillomavirus in cervical cancer: a case report. | the association between schistosoma haematobium and cervical cancer has been reported for a long time. however, recently human papillomavirus, a cofactor in the genesis of cervical cancer, has been confirmed. a case of squamous intraepithelial lesion after s haematobium infection is presented, and the relation between schistosomiasis, human papillomavirus and squamous intraepithelial lesion, with long-term follow-up by papanicolaou smear, is discussed. | 2010 | 20391981 |
| human papillomavirus transmission and cost-effectiveness of introducing quadrivalent hpv vaccination in denmark. | the objective of this study was to simulate human papillomavirus (hpv) infection in a heterosexual population and subsequently analyze the incremental costs and effects of introducing a vaccination program against hpv types 6, 11, 16, and 18 in denmark compared with screening alone. | 2010 | 20392322 |
| association of viral load with hpv16 positive cervical cancer pathogenesis: causal relevance in isolates harboring intact viral e2 gene. | we tested the hypothesis that cervical cancers (cacx) harbor high hpv16 viral load compared to controls and this is influenced by e2 status and age of subjects. viral load (natural log transformed values) per 100ng genomic dna was estimated (152 cases and 87 controls) by taqman assay. median viral load was significantly higher (mann-whitney u test) among cases (17.21) compared to controls (9.86), irrespective of e2 status or upon considering e2 status as a covariate in logistic regression model ... | 2010 | 20394955 |
| rescue of p53 function by small-molecule rita in cervical carcinoma by blocking e6-mediated degradation. | proteasomal degradation of p53 by human papilloma virus (hpv) e6 oncoprotein plays a pivotal role in the survival of cervical carcinoma cells. abrogation of hpv-e6-dependent p53 destruction can therefore be a good strategy to combat cervical carcinomas. here, we show that a small-molecule reactivation of p53 and induction of tumor cell apoptosis (rita) is able to induce the accumulation of p53 and rescue its tumor suppressor function in cells containing high-risk hpv16 and hpv18 by inhibiting hp ... | 2010 | 20395210 |
| tobacco and alcohol use increases the risk of both hpv-associated and hpv-independent head and neck cancers. | tobacco, alcohol, and human papillomavirus (hpv) are major risk factors for head and neck cancer (hnc), but it is unclear whether there are two distinct hnc risk groups, one associated with hpv and the other with tobacco/alcohol. because hpv-positive hnc are clinically distinct from hpv-negative cases in treatment response and with more favorable prognoses, determining whether these differences result from infection alone or in association with other hnc risk factors is important for developing ... | 2010 | 20401530 |
| hpv dna is associated with a subset of schneiderian papillomas but does not correlate with p16(ink4a) immunoreactivity. | this study investigated the role of human papillomavirus (hpv) in schneiderian papillomas (sps) to determine whether hpv is associated with the pathogenesis of particular histologic subtypes and whether p16(ink4a) can be used as a surrogate marker for hpv detection. twenty-seven papilloma specimens (19 inverted [ips], 6 exophytic [eps], 1 oncocytic [op] and 1 mixed) were collected from 23 patients. purified sp dna extracts were tested for hpv by pcr using gp5 +/gp6 + primers; hpv genotyping was ... | 2010 | 20405251 |
| regulation of mcp-1 chemokine transcription by p53. | our previous studies showed that the expression of the monocyte-chemoattractant protein (mcp)-1, a chemokine, which triggers the infiltration and activation of cells of the monocyte-macrophage lineage, is abrogated in human papillomavirus (hpv)-positive premalignant and malignant cells. in silico analysis of the mcp-1 upstream region proposed a putative p53 binding side about 2.5 kb upstream of the transcriptional start. the aim of this study is to monitor a physiological role of p53 in this pro ... | 2010 | 20406462 |
| 4-1bb ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines. | therapeutic subunit vaccines based on tumor-associated antigens (taa) represent an attractive approach for the treatment of cancer. however, poor immunogenicity of taas requires potent adjuvants for therapeutic efficacy. we recently proposed the tumor necrosis factor family costimulatory ligands as potential adjuvants for therapeutic vaccines and, hence, generated a soluble form of 4-1bbl chimeric with streptavidin (sa-4-1bbl) that has pleiotropic effects on cells of innate, adaptive, and regula ... | 2010 | 20406989 |
| is hpv-18 present in human breast cancer cell lines? | 2010 | 20407441 | |
| piwil2 expressed in various stages of cervical neoplasia is a potential complementary marker for p16. | generally, cancers may undergo the developmental stages of benign proliferation, precancer and invasive cancer. identification of biomarkers that are expressed throughout the developmental stages will facilitate detection, prevention and therapy of cancer. piwil2, a member of ago/piwi family of proteins, has been suggested to be associated with tumor development. here we reported that piwil2 can be detected by immunohistochemistry (ihc) in various stages of human cervical squamous cell carcinoma ... | 2010 | 20407605 |
| relevance of human papilloma virus (hpv) infection to carcinogenesis of oral tongue cancer. | human papilloma virus (hpv) infection is controversial as a causative factor in oral tongue cancer. this study aimed to clarify whether hpv directly affects the carcinogenesis and biological behaviour of oral tongue cancer by analyzing hpv prevalence, the physical status of the virus and clinicopathological parameters. archival tissue was obtained from 36 patients diagnosed with t1 and t2 oral tongue cancer and 25 normal controls. hpv genotyping chip and real-time polymerase chain reaction were ... | 2010 | 20413270 |
| [rna interference: biogenesis molecular mechanisms and its applications in cervical cancer]. | rnai (rna interference) is a natural process by which eukaryotic cells silence gene expression through small interference rnas (sirna) which are complementary to messenger rna (mrna). in this process, the sirna that are 21-25 nucleotides long and are known as microrna (mirna), either associate with the rna-induced silencing complex (risc), which targets and cleaves the complementary mrnas by the endonucleolytic pathway, or repress the translation. it is also possible to silence exogenous gene ex ... | 2010 | 20415061 |
| deregulation of stat-5 isoforms in the development of hpv-mediated cervical carcinogenesis. | cervical cancer is the second most common cancer and is leading cause of cancer related deaths in women worldwide. high risk-human papillomavirus (hpv) types play an important role in cervical carcinogenesis. considering the important role of signal transducer and activator of transcription-5 (stat-5), an important member of jak/stat family which plays a crucial role in various cancers and hpv as a key mediator in the development of cervical carcinogenesis, the purpose of the current study was t ... | 2010 | 20415542 |
| increased risk of hiv acquisition among kenyan men with human papillomavirus infection. | few data on the effect of human papillomavirus (hpv) infection on human immunodeficiency virus (hiv) acquisition are available. | 2010 | 20415595 |
| clonal status and clinicopathological observation of cervical minimal deviation adenocarcinoma. | minimal deviation adenocarcinoma (mda) of the uterine cervix is defined as an extremely well differentiated variant of cervical adenocarcinoma, with well-formed glands that resemble benign glands but show distinct nuclear anaplasia or evidence of stromal invasion. thus, mda is difficult to differentiate from other cervical hyperplastic lesions. monoclonality is a major characteristic of most tumors, whereas normal tissue and reactive hyperplasia are polyclonal. | 2010 | 20416098 |
| significance of human papillomavirus genotyping with high-grade cervical intraepithelial neoplasia treated by a loop electrosurgical excision procedure. | this study was conducted to determine whether the human papillomavirus (hpv) genotype by the hpv dna chip test (hdc) is predictive of residual or recurrent high-grade cervical intraepithelial neoplasia (cin) 2-3 following a loop electrosurgical excision procedure (leep). | 2010 | 20417477 |
| what is the role of hpv typing in the united states now and in the next five years in a vaccinated population? | to review the current state of hpv typing of the vaccinated population in the united states and potential for typing of this population over the next 5 years. | 2010 | 20417957 |
| association between human papillomavirus infection and laryngeal squamous cell carcinoma. | the aim of this study was to compare the prevalence of human papillomavirus (hpv) infection in laryngeal squamous cell carcinoma using two methods: pcr-dna enzyme immunoassay (pcr/deia) and immunohistochemistry (ihc) for detection of hpv in specimens of laryngeal squamous cell carcinoma and to correlate the presence of hpv with the epidemiological and clinicopathological features of recurrence and survival. hpv dna was amplified from 93 paraffin-embedded laryngeal squamous cell carcinoma tissue ... | 2010 | 20419817 |
| [factors associated with abnormal cervical cytology in pregnant women]. | to investigate the risk factors associated with abnormal cervical cytology findings in pregnant women. | 2010 | 20420780 |
| lymphoepithelial-like carcinoma of the oropharynx: a morphologic variant of hpv-related head and neck carcinoma. | human papillomavirus-associated squamous cell cancer of the head and neck (hpv-hnscc) represents an important subgroup of head and neck cancer that is characterized by distinct epidemiologic, clinical, and pathologic features including a relatively constant microscopic appearance. for those cancers that deviate from the morphologic prototype, an association with hpv may not be recognized and accurate tumor classification may not be achieved. we have identified 22 cases of hpv-hnscc with well-dev ... | 2010 | 20421782 |
| high prevalence and low e6 genetic variability of human papillomavirus 58 in women with cervical cancer and precursor lesions in southeast mexico. | infection with some genotypes of human papillomavirus (hpv) is the most important risk factor associated with cervical cancer (cc). throughout the world, hpv type 58 prevalence varies from one region to another; it is higher in women from certain countries in asia and latin america, such as china and mexico. although intratypic variants have been reported on a few occasions, our knowledge about hpv 58 genetic variation remains limited. therefore, this work aims to (i) determine the prevalence of ... | 2010 | 20428672 |
| e6/e7 mrna expression analysis: a test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure. | detection of e6/e7 mrna expression using the real-time nucleic acid sequence-based amplification assay (nasba) pretect hpv-proofer was compared with results of human papillomavirus (hpv) dna detection in 98 paraffin-embedded samples from patients with cervical adenocarcinoma. hr-hpv dna was detected in 61 (62%), while hr-hpv e6/e7 mrna was detected in 63 (64%) of the samples. correlation between results from dna analyses and the e6/e7 mrna assay showed consistent results in 87% of samples (47 of ... | 2010 | 20428778 |
| estimating clinical outcome of hpv induced cervical lesions by combination of capsid protein l1 and p16ink4a protein detection. | the aim of this study was to investigate whether is possible to predict clinical outcome of cervical lesion by immunoassaying performed on cervical smears. during the two year study period the cervical smears of 81 patients were collected. all patients were tested for human papillomavirus (hpv) infections using amplycor hpv test. sixty-six of them were tested as positive for high risk types (hrhpv) and squamous intraepithelial lesion, and in those patients repeated cervical smears were taken eve ... | 2010 | 20432730 |
| detection of human papillomaviruses type 16, 18 and 33 in bronchial aspirates of lung carcinoma patients by polymerase chain reaction: a study of 84 cases in croatia. | besides its well-known role in cervical carcinoma, hpv is also suggested to be involved in lung cancer development. a number of authors have been investigating the presence of hpv in histological materials. we used routine bronchial aspirates from 84 patients with lung carcinoma for dna extraction and then performed polymerase chain reaction for high-risk hpv types 16, 18 and 33. the results were compared to those obtained from buccal and eyelid mucosa. only three patients were positive for hpv ... | 2010 | 20432745 |
| human papillomavirus and cervical cancer: gardasil vaccination status and knowledge amongst a nationally representative sample of australian secondary school students. | the aim of this paper was to measure student knowledge of hpv and risks associated with cervical cancer, explore associated factors, correlate knowledge of hpv and cervical cancer with other domains of sexual health related knowledge and estimate student self-reported rates of hpv immunisation. data were from a nationally representative cross-sectional stratified cluster sample of year 10 and 12 students in the australian secondary school system. contingency table, comparison of means, correlati ... | 2010 | 20434543 |
| vaccination with multimeric l2 fusion protein and l1 vlp or capsomeres to broaden protection against hpv infection. | immunization with l1 as pentavalent capsomeres or virus-like particles (vlps) generates high and long-lived titers of neutralizing antibodies and protection primarily against the human papillomavirus (hpv) type from which the vaccine was derived. conversely, vaccination with l2 minor capsid protein derived from multiple hpv types induces lower titer, but more broadly neutralizing and protective antibody responses. we combined the advantages of each protective antigen by immunization with titrate ... | 2010 | 20434552 |
| role of t cell competition in the induction of cytotoxic t lymphocyte activity during viral vector-based immunization regimens. | t cell competition between antigen- and vector-specific t cells may determine the outcome of viral vector-based immunization regimens, as we previously proposed. here, we unravelled the interplay between antigen- and vector-specific immunity, using recombinant semliki forest virus (rsfv). priming of mice with rsfv, encoding lacz (sfvlacz), or with empty rsfv strongly suppressed subsequent induction of ovalbumin or human papilloma virus (hpv) e6/e7-specific ctl activity by a booster with sfveova ... | 2010 | 20434555 |
| the japanese guideline for cervical cancer screening. | cervical cancer is the 11th leading cause of death from cancer for females in japan. in 2005, there were 2486 deaths from cervical cancer, accounting for 1.8% of the total number of cancer deaths in japan. cervical cancer screening using conventional cytology has been conducted worldwide. the guideline for cervical cancer screening was developed based on the established method. the efficacies of conventional and liquid-based cytology, human papillomavirus testing alone and two combination method ... | 2010 | 20436034 |
| influence of partner's infection status on prevalent human papillomavirus among persons with a new sex partner. | we evaluated the influence of the partner's human papillomavirus (hpv) status and sexual practices on prevalent hpv infection among new couples to study hpv transmission. | 2010 | 19704391 |
| validation of thermofisher's papspin for human papillomavirus detection in cervicovaginal specimens using pcr with gp5+/gp6+ primers and the hybrid capture ii assay. | the present study aimed to validate thermofisher's (thermo fisher scientific, runcorn, cheshire, uk) papspin (ps) for human papillomavirus (hpv) testing by in-house pcr and by the hybrid capture ii (hc2) assay and to compare the results with those obtained using specimen transport medium (stm) (digene diagnostics, gaithersburg, md, usa). forty-five patients underwent conization for known lesions ranging from atypical squamous cells of undetermined significance (asc-us) with high-risk hpv (hr-hpv ... | 2010 | 19689463 |
| is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality? | the incidence of human papilloma virus (hpv) induced oropharyngeal squamous cell carcinoma (opscc) increases in the western countries. these opscc show distinct molecular characteristics and are characterized by an overexpression of p16, considered a surrogate marker for hpv infection. when compared to patients with p16 negative opscc, patients with hpv induced p16 positive opscc show a significantly better prognosis, which is reported to be caused by increased radiosensitivity. the objective of ... | 2010 | 19697324 |
| hpv-positive/p16-positive/ebv-negative nasopharyngeal carcinoma in white north americans. | human papillomavirus (hpv) has been detected in keratinizing nasopharyngeal carcinomas (npcs); however, the relationship between hpv and epstein-barr virus (ebv) among whites with nonkeratinizing npcs remains unclear. the hpv, p16, and ebv status was examined in current university of michigan patients with npc. | 2010 | 19757421 |
| human papillomavirus type 16 e6 gene variations in chinese population. | to identify genetic variants in the e6 gene of hpv 16 and to examine the association between these variants and cervical cancer development. | 2010 | 19699050 |
| the association between fruit and vegetable consumption and hpv viral load in high-risk hpv-positive women with cervical intraepithelial neoplasia. | we evaluated the relationship between the dietary intake of vegetables and fruits, and the risk of cervical intraepithelial neoplasia (cin) and determined whether these associations were modified by human papillomavirus (hpv) viral load. we enrolled 1,096 women aged 18-65 to participate in a hpv cohort study from march 2006 up to present. for this analysis, we included 328 hpv-positive women (166 controls, 90 cin i and 72 cin ii/iii). the multivariate odds ratios (ors) and corresponding 95% conf ... | 2010 | 19777358 |
| homocysteine levels are associated with cervical cancer independent of methylene tetrahydrofolate reductase gene (mthfr) polymorphisms in indian population. | human papillomavirus is considered to be a major aetiological factor but is not sufficient for the development of cervical cancer. other host factors, including altered homocysteine levels, a functional marker of folate inadequacy, might contribute to the carcinogenic process. herein we investigated the potential association of homocysteine levels and mthfr polymorphisms with cervical cancer in 203 histologically confirmed cases including 39 precancer cases and 231 healthy controls with normal c ... | 2010 | 19793004 |
| papillomavirus interaction with cellular chromatin. | high-risk human papillomavirus (hpv) infection is the primary risk factor for cervical cancer. hpvs establish persistent infection by maintaining their genomes as extrachromosomal elements (episomes) that replicate along with host dna in infected cells. the productive life cycle of hpv is intimately tied to the differentiation program of host squamous epithelium. this review examines the involvement of host chromatin in multiple aspects of the papillomavirus life cycle and the malignant progress ... | 2010 | 19786128 |
| low expression of human histocompatibility soluble leukocyte antigen-g (hla-g5) in invasive cervical cancer with and without metastasis, associated with papilloma virus (hpv). | human leukocyte antigen-g (hla-g) is a non-classical major histocompatibility complex class ib molecule that acts as a specific immunosuppressor. some studies have demonstrated that human papillomavirus (hpv) seems to be involved in lower or absent hla-g expression, particularly in cervical cancer. in this study, we performed a cross-sectional study, systematically comparing the qualitative expression of the hla-g5 isoform in invasive cervical carcinoma (icc), stratifying patients according to t ... | 2010 | 19786613 |
| outcomes from a mass media campaign to promote cervical screening in nsw, australia. | despite the decline in the incidence of cervical cancer in australia as a result of population screening, a substantial proportion of women in nsw screen less regularly than the recommended two-yearly interval or do not screen. with higher rates of cervical cancer in unscreened and underscreened women, and despite the introduction of the human papillomavirus vaccine, there remains a need to continue to remind women to screen. the mass media has been shown to be effective at improving participati ... | 2010 | 19822553 |
| induction of human papillomavirus oncogene-specific cd8 t-cell effector responses in the genital mucosa of vaccinated mice. | cervical cancer, the second leading cause of cancer mortality in women worldwide, results from infection with a subset of human papillomaviruses (hpv), hpv-16 being the most prevalent type. the available prophylactic vaccines are an effective strategy to prevent this cancer in the long term. however, they only target 70-80% of all cervical cancers and cannot control existing hpv infections and associated lesions. therapeutic vaccines are thus necessary for women who cannot benefit from prophylac ... | 2010 | 19816937 |