Publications

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mycobacterium leprae in a muscle spindle. 19724262739
studies on mycobacterium leprae in media enriched by mycobacterial substances. 19724592899
the effect of antibacterial drugs on the ultrastructure of mycobacterium leprae in human skin. 19724579978
demonstration of mycobacterium leprae and its viability in the peripheral blood of leprosy patients. 19724579979
evidence that the mechanism of immunological tolerance ("central failure") is operative in the lack of host resistance in lepromatous leprosy. 19724590279
[leprosy research]. 19714327066
kinetic testing of drugs against mycobacterium leprae in mice. activity of cephaloridine, rifampin, streptovaricin, vadrine, and viomycin. 19714398128
sequential blockade of the mycobacterial de novo folate pathway. a review. 19714399473
experimental arthus reactions using the same antigen in soluble and corpuscular form. 19714255853
attempts at the cultivation of m. leprae in cell-free, semi-synthetic soft agar media. 19714112523
the morphological index. 19714113655
stain techniques and the morphology of mycobacterium leprae. 19714113656
modification of fite faraco staining for acid fast bacilli. 19714113757
elimination of the acid fastness but not the gram positivity of leprosy bacilli after extraction with pyridine.bacilli from a number of tissues excised from cases of lepromatous and borderline leprosy, unlike mycobacteria, were found to lose their acid-fastness after treatment with pyridine.19714102336
antileprosy drugs. 19714104273
prevention of leprosy. 19714105673
activity of thiozamin (p-(p'-aminobenzenesulfonyl)-benzaldehyde thiosemicarbazone) against mycobacterium leprae infections in mice. 19714927841
application of spectrophotofluorometric procedures to some problems in mycobacterium leprae infections in mice and man treated with dapsone (dds), diacetyl-dds (dadds), and di-formyl-dds (dfd). 19714928595
leprosy vaccines. 19714929580
a preliminary report on the use of the depot sulphone preparation acedapsone ("hansolar") in the control of leprosy. 19714935561
[morphology of lepra cells]. 19714937112
leprosy. 19714937166
johnes bacillus and mycobactins. 19714938014
[localization and topographic distribution of hansen's bacilli at the level of leprotic lesions]. 19714938032
the fate of mycobacterium leprae in cba mice. 19714939048
effect of neonatal thymectomy and antithymocytic serum on susceptibility of rats to mycobacterium leprae infection. 19714940737
[leprosy as a mycobacterial disease and its control in cuba]. 19714941062
antitissue versus antimicrobial cellular immunity: a perspective. 19714941265
surface peptido-glycolipid filaments on mycobacterium leprae. 19714941663
acid-fast bacilli in the bone marrow in leprosy. 19714945324
cultivation of the douglas strain of mycobacterium lepraemurium in continuous culture.cultivation of mycobacterium lepraemurium in cell-free media has not yet been successful, perhaps because of deterioration of the nutritional quality of the medium with prolonged incubation at 37 degrees c. trials with a continuous culture technique, involving regular change of a simple liquid medium prepared from human placenta, demonstrated active fission of the myco. lepraemurium cells. abundant growth in the form by macroscopically visible colonies has not been achieved even after prolonged ...19714945632
characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating mycobacterium leprae-reactive lymphocytes. 19714945738
[lysosomes in the pathology of leprosy]. 19714945785
the multiplication of mycobacterium leprae in mouse foot-pads and the ambient temperatures. 19714946423
bacterial counts of mycobacterium leprae on media enriched by substances of mycobacterial origin. 19714947057
[objective validity of the culture method of m. leprae using cell-free, semi-liquid agar media]. 19714947894
the impact of experimental human leprosy in the mouse on leprosy research. 19714948076
the response of the patient with leprosy toward mycobacterium leprae injected with lepromin. a histopathologic study four hours after injection. 19714948077
observations on in vitro survival of mycobacterium leprae. 19714948078
the present state of growth of m. leprae under in vitro conditions. 19714948079
histologic changes evoked in mice by freund's adjuvant, complete with m. leprae. 19714948082
immunologic researches in leprosy. diagnostic applications. 19714948090
antigenic properties of some mycobacterial strains isolated and cultivated from leprosy tissue. 19714948091
leprosy--research at the forschungsinstitut borstel. 19714948101
attempts to establish the armadillo (dasypus novemcinctus linn.) as a model for the study of leprosy. i. report of lepromatoid leprosy in an experimentally infected armadillo. 19714948218
the treatment of leprosy with the sulfones. i. faget's original 22 patients. a thirty-year follow-up on sulfone therapy for leprosy. 19714948221
activity against m. leprae of lincomycin and two derivatives, of amicetin, phosphonomycin and two derivatives of tetrahydronaphthylaminopropylpiperidine. 19714948222
delayed lepromin reaction and bcg application in first grade school children in s. paulo, brazil. 19714948223
m. leprae and its affinity for nerves. 19714948225
studies on the determination of the minimal inhibitory concentration of 4,4'-diamino-diphenyl-sulphone (dapsone, dds) against mycobacterium leprae. 19714948480
bacteriological effect of lamprene (clofazimine) in lepromatous leprosy (report of one year's treatment of 44 patients with 100 mg of lamprene daily). 19714948481
the sfg (solid, fragmented, granular) index for bacterial morphology. 19714948482
further electron-microscopic observations of mycobacterium lepraemurium. 19714948636
transformation of leprous lymphocytes by leprolin, tuberculin and phytohemagglutinin. 19714949308
effect of dapsone in eliminating m. leprae from the skin of lepromatous patients, a study of 609 cases. 19714949310
statistical calculations of the confidence interval and significant difference ranges of the morphologic index. 19714949311
fate of mycobacterium leprae in macrophages. 19714949314
mycobacterium leprae in cultured mouse peritoneal macrophages: in vivo infection-in vitro cultivation. 19714949821
the first decade in experimental leprosy.considerable developments have occurred in the application of the method for growing mycobacterium leprae in the mouse foot-pad since it was first described about 10 years ago. the method has been used to study growth curves and histology in normal and in thymectomized irradiated mice, to identify supposed isolates of myco. leprae that have been made in tissue-culture or in non-living media, to evaluate tests of experimental vaccines, to investigate applications to clinical investigations (the l ...19714950564
[hand muscle paralysis in leprosy and its surgical treatment]. 19714951024
immunological significance of changes in lymph nodes across the leprosy spectrum. 19714930640
treatment with 4,4'-diacetyldiaminodiphenylsulfone (dadds) of leprosy patients in the karimui, new guinea. 19714932529
[history of the discovery of the causative agent of leprosy]. 19714944559
growth of mycobacterium lepraemurium in diffusion chambers containing human embryonic skin cells and in cell-free chambers. 19714944588
the effect of freezing and storage at -60 degrees c on the viability of mycobacterium leprae. 19714944742
armadillo may aid leprosy research. 19714944922
[electron microscope study of cultivated mycobacteria from human lepromas. i. morphological observations]. 19714935110
[electron microscopy study of cultivated mycobacteriacea from human lepromas. ii. remarks on various peculiar structures]. 19714935111
studies of immune mechanisms in leprosy. 3. the role of cellular and humoral factors in impairment of the in vitro immune response. 19714995005
unusual effects of reducing agents on 0-diphenoloxidase of mycobacterium leprae.reducing agents had no effect on the oxidation of 3,4-dihydroxyphenylalanine (dopa) to quinone by mycobacterium leprae; no quinone formation by o-diphenoloxidase of mammalian or plant origin was detected under similar experimental conditions. ascorbic acid and reduced glutathione prevented further oxidation and polymerization of the quinone to melanin by m. leprae; cysteine was less effective. in the presence of reducing agents, the quinone (indole-5,6-quinone) formed from dopa by m. leprae was ...19714999415
immunologic analysis of mycobacterium leprae antigens by means of diffusion-in-gel methods. 19715003224
neurofibromatosis and leprosy. 19715003511
in vitro behavior of macrophages from healthy persons against m. leprae and other mycobacteria. 19715004598
problems in the cultivation of mycobacterium leprae. related cultivation and biochemical studies with mycobacterium lepraemurium. 19715169802
the activity of various antituberculous drugs in suppressing experimental mycobacterium leprae infection in mice. 19715169803
the ecology of the atypicalmycobacteria. 19714991961
relationship between the staining quality of mycobacterium leprae and infectivity for mice.the proposal has been made that only solidly staining forms of mycobacterium leprae are viable. on the basis of a previous study, solidly staining bacilli were defined as those that stained completely and darkly throughout their length. a study was carried out to correlate the proportion of solidly staining bacilli in inocula with the infectivity and rate of appearance of bacillary growth in inoculated mice. the inocula originated in skin biopsy specimens of patients and in mouse passage materia ...197116557926
hereditary characteristic that varies among isolates of mycobacterium leprae.isolates of mycobacterium leprae in mouse foot pads were found to differ in two related properties, the average rate of growth between inoculation and harvest (g) and the number of bacilli in the harvest (h). for "fast" strains the median values for g were less than 25 days per generation, and the median values for h were above 10(6.1). for "slow" strains the median values for g were above 30, and the median values for h were below 10(5.6). the g and h values for the 59 isolates for which data w ...197116557927
[further studies on the serological diagnosis of leprosy. ii. effect of the rate of development and treatment on the result of complement fixation tests in comparison to bacilloscopy]. 19704992242
bacterial negativity and reactivation (relapse) of lepromatous outpatients under sulfone treatment. 19704993550
studies on the antigenic specificity of mycobacterium leprae. i. demonstration of soluble antigens in leprosy nodules by immunodiffusion. 19704990996
studies towards the standardization of lepromin. progress and prospects.because of the wide range of concentrations of mycobacterium leprae in existing lepromins the authors studied methods of producing a standardizable lepromin containing 160 million bacilli/ml. the effects of using different dilutions of lepromin on the incidence of false-positive reactions were also studied.progress reported includes a convenient method for preparing large batches of non-sedimenting lepromin, which is directly suitable for microscopic counting of myco. leprae cells; and a validat ...19705311057
some recent laboratory findings on mycobacterium leprae. implications for the therapy, epidemiology and control of leprosy.from changes in the morphology and viability of mycobacterium leprae in infected mice, some authors have concluded that the majority of smear-positive human lepromatous patients become non-infectious within 3-4 months of the beginning of regular treatment with sulfones, even at dosages equivalent to only one-hundredth of the conventional daily dose-namely, 1 mg daily. these very low dosages have, however, not been advocated because of the risk that resistant strains of myco. leprae might develop ...19705313068
immunological problems in leprosy research. 1. clinical and pathological spectrum of leprosy.this paper discusses the evidence for and against the view that the spectrum of pathological changes in leprosy, extending from the lepromatous form to the tuberculoid form, may be caused by differences in the immune responses of patients. patients with the tuberculoid form of leprosy generally have well-developed specific cell-mediated immunity, but in a large proportion of patients with lepromatous leprosy the specific cell-mediated immunity to mycobacterium leprae and sometimes to other antig ...19705314019
bacteriology and pathological study of leprous lesions in the footpads of mice. 19704944997
studies on murine leprosy bacillus. i. attempt to cultivate in vitro the hawaiian strain of mycobacterium lepraemurium. 19704934001
[ameloblastoma of gingival origin complicated by a secondary infection]. 19704934464
placental infection in the fetuses of pregnant murine leprous mice. 19704931034
visceral lesions caused by m. leprae--a histopathological study. 19704941851
some aspects of the pathology of nerves in leprosy. 19704941852
introduction to the symposium on leprosy. 19704941855
the minimal inhibitory concentrations of sulphadimethozine and sulphadoxine against mycobacterium leprae. 19704929814
electron-microscope illustrations of division in mycobacterium leprae. 19704919581
studies on cellular immunity in leprosy. i. lysosomal enzymes. 19704929372
fate of mycobacterium leprae in macrophages of patients with lepromatous or tuberculoid leprosy. 19704929374
experimental infection of mice with mycobacterium leprae hominis: additional data. 19704920319
a method of classifying solid leprosy bacilli based on the number of band structures on them. 19704920410
clinical stages in sulfone treatment of leprosy. 19704920411
effects of the depth of culture medium on elongation of mycobacterium lepraemurium in vitro. 19704922036
a comparative study of mouse foot pad inoculation of skin biopsy specimens from patients with lepromatous leprosy in san francisco and atlanta. 19704922037
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