Publications

leoprosy- clinical aspectos of nerve involvement.	leprosy is the cause of the commonest peripheral neuropathy. the predilection of mycobacterium leprae for nerve tissue accounts for the clinical features that are most dreaded and most characteristic of the disease. were it not for the progressive destruction of peripheral nerve trunks and the consequences of this, leprosy would largely remain a cutaneous condition of cosmetically unsightly hypopigmented or erythematous areas and aggregations of nodular thickenings. the neurologic damage in lepr ...	1975	166794
leprosy--histopathologic aspects of nerve involvement.	the most striking single feature of the clinical manifestations of leprosy is the very wide range of appearances shown by the skin lesions. these include the vague, hypopigmented macules of indeterminate leprosy; the large, sharply defined hypopigmented anaesthetic lesions of tuberculoid leprosy; the nodules and diffuse infiltration of lepromatous leprosy; and a wide range of plaques and annular lesions of the intermediate (borderline or dimorphous) types of disease. from superficial appearances ...	1975	166795
uptake of radioactive dopa by mycobacterium leprae in vitro.	our previous studies demonstrated that mycobacterium leprae contains a characteristic o-diphenoloxidase which converts a variety of phenolic compounds to quinones in vitro. this enzyme was not present in any other mycobacteria tested. the results reported here deal with the uptake and binding of radioactive dopa by m. leprae. the leprosy bacilli incubated with tritium-labelled dopa, readily took up the substrate. the binding of dopa by the bacilli was markedly inhibited by diethyldithiocarbamate ...	1975	171542
lepromatous leprosy presenting with polyarthritis, myositis, and immune-complex glomerulonephritis.	a pakistani man aged 19 years was admitted to a rheumatological unit in the united kingdom with acute widespread polyarthritis accompanied by night sweats and fever. preliminary examination suggested reiter's disease, but further investigation showed acute glomerulonephritis with uraemia. the possibility of periarteritis nodosa, and the prominence of muscle tenderness in the legs, led to biopsies of striated muscle and skin, in both of which were changes typical of lepromatous leprosy, with many ...	1975	126102
an ultrastructural study of neuromuscular spindles in normal mice: with reference to mice and man infected with mycobacterium leprae.	mycobacterium leprae have been found within muscle spindles in mice, using electron microscopy, and in man, using light microscopy. their mode of entry clearly is important. it may be via capsular cells, capillaries or nerves. for this reason muscle spindles from normal mice were studied by electron microscopy with special reference to the capsule and the relationship of it with capillaries and nerves, as well as details of the intrafusal fibres and capsular space. a fenestrated capillary was fo ...	1975	126981
glomerular subepithelial deposits in lepromatous leprosy.		1975	127533
mycobacterium leprae in human skeletal muscle.		1975	782385
a histopathologic study of striated muscle biopsies in leprosy.	histopathologic changes in striated muscle biopsies in 50 cases of leprosy were studied; 40 being the lepromatous type and 10 the nonlepromatous type. all the biopsies were obtained from midportions of normal looking biceps muscles and paraffin embedded. sections cut in transverse and longitudinal planes were stained by hematoxylin and eosin, masson's trichrome, mallory's ptah, gomori's silver impregnation, and ziehl-neelsen's technic. lepromas, focal or confluent, in the endomysium, perimysium, ...	1975	776842
[sensitivity to dapsone, sulfamethoxypyridazine and ethionamide of mycobacterium leprae taken from patients treated by the drugs].	suspensions of m. leprae from skin biopsies of patients treated with dapsone (dds) (four cases), sulfamethoxypyridazine (smp) (six cases), and ethionamide (eth) (seven cases), were inoculated into mouse foot pads and their sensitivity for the different drugs determined. two strains were dds resistant. resistance appeared after 13 and 14 years respectively after the start of treatment. five strains were isolated from patients treated with smp. relapses during sulfonamide treatment are considered ...	1975	776843
bacteriological status (point prevalence) of lepromatous outpatients under sulfone treatment.	the study concerns 337 outpatients with lepromatous leprosy who had been receiving dapsone treatment for 1-26 years-69% of them regularly and 31% irregularly. routine bacterial examination (10 min per slide) by a paramedical technician showed only 50% of these patients to be bacteriologically positive. this rate attained 99% when each slide was examined for 30-60 min by a qualified bacteriologist. other factors-apart from the limited action of sulfones-might account for these unexpected results: ...	1975	764995
bacillaemia in leprosy.		1975	765273
schwann cell changes in lepromatous leprosy--an electronmicroscope study.		1975	765274
development of leprosy in another species of armadillo dasypus hybridus (l): genetic and immunologic implications.		1975	765488
in vitro cultivation of leprosy bacilli on hyaluronic acid based medium. 1. preliminary report.	in vitro cultivation is reported of mycobacterium leprae on a medium (designated la-3) based on hyaluronic acid with additional ingredients of yeast extract, bovine albumin and glycerin together with phosphate buffer. the medium is also incorporated with agar or agarose (designated la-3p) to serve as culture plates. initial growth in la-3 in test tubes required about six weeks but subsequently this was speeded up to about two weeks utilizing large quantities of media with aeration by shaking twi ...	1975	767262
specific direct fluorescent antibody identification of mycobacterium leprae.	in vitro cultivation of m. leprae requires a rapid, specific identification procedure for monitoring the cultures. a method utilizing direct fitc-coupled lepromatous, specific serum globulin is described in detail with suggestions for improvement. after various purification and adsorption procedures, notably against human liver powder and m. tuberculosis, a fluorescent serum preparation is obtained which specifically reacts with m. leprae and not with other mycobacteria.	1975	767263
[the etiological mystery of sarcoidosis].		1975	804178
susceptibility of thymectomized and irradiated mice to challenge with several organisms and the effect of dapsone on infection with mycobacterium leprae.	b6c3f1 mice that had been thymectomized at 8 to 12 weeks of age, subjected to 950 r of whole-body x irradiation, and transfused with syngeneic bone marrow were challenged in a footpad with mycobacterium leprae or m. marinum, or intravenously or intraperitioneally with listeria monocytogenes. also, mice inoculated with m. leprae in a hind footpad were administered dapsone in the mouse chow. the thymectomized-irradiated (t + r) mice did not survive as well as non-thymectomized mice when housed in ...	1975	804443
amyloid-related serum component (protein asc) in leprosy patients.	the presence of amyloid-related serum component, protein asc, in serum samples from 63 leprosy patients was investigated. protein asc was detected in 38% of the patients. a correlation to the disease spectrum of leprosy was apparent: polar lepromatous cases, 64% positive; borderline lepromatous, 50%; borderline tuberculoid, 36%; subpolar tuberculoid, 17%; and polar tuberculoid, negative. antibody activity against the a antigen of mycobacterium leprae was also determined, showing a similar correl ...	1975	804451
antigenic evaluation of mycobacterium lepraemurium.	immunodiffusion analysis of mycobacterium lepraemurium indicated the presence of at lease six antigens. comparative analysis of the m. lepraemurium antigen-antibody system with similar systems established for other mycobacterial species, showed that m. lepraemurium shared up to two antigens with other species. although our observations are in accord with some of the studies on the antigenic mosaic of m. lepraemurium, they are in disagreement with the observations of stanford (1973) concerning a ...	1975	805240
o-diphenoloxidase of mycobacterium leprae separated from infecected armadillo tissues.	we reported earlier the occurrence of a unique o-diphenoloxidase in mycobacterium leprae recovered from lepromatous human tissues. no other source of m. leprae fro biochemical studies was available at the time. in the present report, properties of phenoloxidase in m. leprae separated from infected armadillo tissues are presented. the results show that the o-diphenoloxidase remains unaltered in the passage of the bacilli from the human to the the animal host, indicating that the enzyme is an intr ...	1975	807522
[in-vitro study of the effects of 4,4-diamino-diphenylsulphone in combination with isoniazid and rifampicin (author's transl)].		1975	810790
experimental leprosy in the nine-banded armadillo.		1975	813256
editorials: problems in identifying m. leprae.		1975	815182
preliminary taxonomic studies on the leprosy bacillus.	antigens extracted from leprosy bacilli obtained from infected human and armadillo tissues have been examined by immunodiffusion analysis with serum samples from lepromatous patients and with immune sera raised in rabbits. using the best combinations of serum and antigen extracts, 12 antigenic constituents were found in the leprosy bacilli. six of these were antigens common to all mycobacteria and nocardiae, 4 were specific to the leprosy bacillus and the position of 2 could not be determined. g ...	1975	816369
the immune system of the nine-banded armadillo (dasypus novemcinctus, linn).	the armadillo is rapidly emerging as an animal for biomedical research. a morphological study of the immune system of the armadillo was undertaken to try to demonstrate a possible defect in the morphogenesis of the lymphoid organs that could account for their susceptibility to leprosy. blood from 20 domesticated adult armadillos revealed lymphocytes predominated among circulating leukocytes in the majority of animals, whereas in wild animals neutrophils predominated. necropsies revealed well-dev ...	1975	1091181
superinfection in mice previously infected with mycobacterium leprae.	previous studies of the protection of mice by prior infection with mycobacterium leprae in one hind footpad against challenge with m.leprae in the opposite hind footpad had produced conflicting results; therefore, the problem was restudied. in several experiments, balb/c mice were inoculated first in the right hind footpad with 5,000 m. leprae and then challenged in the left hind footpad with 5,000 m. leprae of the same strain at intervals after primary infection, at the same time that uninfecte ...	1975	1091561
further investigations on m. leprae. growth promotion and inhibition by organic substances and observations on antagonistic and syntergistic effects.	the multiplication of 2 strains of m. leprae on a medium containing a sonic extract (se), prepared from m. smegmatis, was promoted by cysteine, tryptophane and dimethylasulfoxide (dmso), while glutamic acid, glutamine and histidine exerted variable effects. the final effects of glutamic acid and glutamine were determined by the total concentration of both compounds together. the presence of cysteine and glutamic acid alone or together with dmso abolished all inhibitory effects. desferal did n ...	1975	1092313
immune responses to mycobacterium leprae in man.		1975	1092818
the activity of chaulmoogra acids against mycobacterium leprae.	the activity of the crude sodium salts of the fatty acids of chaulmoogra oil and of hydnocarpic and chaulmoogric acids against mycobacterium leprae was studied in mouse footpad infection. multiplication of the organisms was inhibited when the salts were administered intraperitoneally and subcutaneously 3 times per week, and when chaulmoogric acid was administered intraperitoneally 5 times per week in half the equivalent dose. dihydrochaulmoogric acid was also active, whereas palmitic acid was no ...	1975	1093460
chemotherapy in leprosy.		1975	1093982
hairless mice, human leprosy and thymus-derived-lymphocytes.		1975	1095394
in vitro lymphocyte response to purified protein derivative, bcg and mycobacterium leprae in a population not exposed to leprosy.	lymphocytes from 14 bcg-vaccinated donors, seven tuberculin positive and seven tuberculin negative by skin testing, were stimulated in vitro with four mycobacterial antigens, purified protein derivative (ppd), ppd/bcg, whole bcg bacilli, and whole mycobacterium leprae and also with candida antigen and phytohemagglutinin. the response was measured by incorporation of (3)h-labeled thymidine. the response to ppd, ppd/bcg, and bcg was found to correlate with the result of skin testing with turbercul ...	1975	1095479
immunological studies on leprosy: separation and evaluation of the antigens of mycobacterium leprae.	chromatographically separated antigens of mycobacterium leprae were tested for their ability to elicit skin reactions in guinea-pigs sensitised with homologous and heterologous mycobacteria. of the three antigen-positive fractions obtained, one showed specific activity and the other two cross-reactivity, as indicated by studies of hypersensitivity and passive cutaneous anaphylaxis. the fraction exhibiting specificity contained only one antigen, which was protein in nature, whereas the other two ...	1975	1095749
[reproduction of mycobacterium leprae inoculated into rats fed with putrid cow meat].		1975	1096261
impairment of reactivity to lepromin by mycobacterial antigens related to, or identical with, mycobacterium leprae.	three hundred and twenty young children were injected with bacillus calmette-guerin (bcg) saline, or with one of the mycobacterial cytoplasmic antigens related with mycobacterium leprae. at an appropriate time thereafter they were tested for dermal hypersensitivity to the antigens and for reactions to lepromin. whereas all the antigens induced cell-mediated immunity, the incidence and intensity of late response to lepromin were significantly reduced in children preinjected with the cytoplasmic m ...	1975	1097072
leprosy of the upper respiratory tract. a clinical bacteriological, histopathological and histochemical study of twenty cases.	twenty cases clinically diagnosed as leprosy were thoroughly examined for e.n.t. lesions. these lesions were subjected to bacteriological, histopathological and histochemical studies. the results have been tabulated and discussed with special stress on some findings which are of help in diagnosing the disease.	1975	1097553
the testis in mice infected with mycobacterium leprae.	following inoculation either locally or intravenously with mycobact. leprae of human origin, the histopathology and bacteriology of the testis in experimental mice is described. normal mice, and mice rendered immunologically deficient by thymectomy and whole-body irradiation, were studied. attention is drawn to a heavy bacillation of the testis in mice from both groups. bacilli were found in and beneath the tunica albuginea, but mainly in interstitial cells and in macrophages surrounding the tub ...	1975	1097612
leproma of the mouse foot.		1975	1097852
rifampin therapy of lepromatous leprosy.	patients with borderline-lepromatous (bl) or fully lepromatous (ll) leprosy were treated in the sanitarium for approximately 1 year with oral rifampin (600 mg daily) or with oral dapsone (100 mg daily). they were then treated as outpatients with intramuscular acedapsone (225 mg every 12 weeks) or oral dapsone (50 mg daily). they have now been followed for a total of 28 to 34 months. death of mycobacterium leprae during the initial 24 weeks was monitored by mouse inoculation with m. leprae from s ...	1975	1098495
acedapsone (dadds) treatment of leprosy patients in the karimui of papua new guinea: status at six years.	acedapsone (dadds), a repository sulfone given by injection five times a year, has been used since 1967 for the treatment of all leprosy patients in the karimui, an area of diffic-lt access. more than 460 patients have been treated, 336 beginning in november 1967 and continuing through the latest assessment 6 years later. the injections have been well received and they have been administered very regularly. clinical observations were begun before 1967, as a base-line of assessments was available ...	1975	1098496
acid mucopolysaccharide metabolism in leprosy. 3. hyaluronic acid mycobacterial growth enhancement, and growth suppression by saccharic acid and vitamin c as inhibitors of beta-glucuronidase.	a series of pilot studies are presented utilizing mouse and human infections with m. leprae and mouse infections with m. lepraemurium relating to the previously reported finding that hyaluronic acid seems to be a major nutrient substrate for these bacilli. the "feeding" of hyaluronic acid to the bacilli enhanced the growth of m. leprae in mouse abdominal walls and increased the morphologic index of m. lepraemurium infection. saccharic acid, an inhibitor of beta-glucuronidase previously reported ...	1975	1099016
effect of quinacrine, chloroquine and primaquine on the multiplication of mycobacterium leprae in mice.	quinacrine administered in 100 mg per kg body weight to mice had a bacteriostatic activity on m. leprae in the mouse, chloroquine at 15 mg per kg and primaquine at 0.25 mg per kg were without activity. these findings could point to the presence of a functioning direct oxidative pathway of glucose catabolism in m. leprae.	1975	1099017
a comparative evaluation of bacteriologic and morphologic indices of mycobacterium leprae in skin, lymph node, bone marrow, nerve and muscle.	this study elicits the comparative evaluation of the bacteriologic index (bi) and morphologic index (mi) of the skin, lymph node, bone marrow, nerve and muscle tissues of 15 untreated leprosy patients. the findings of comparable or even higher bi's and mi's in lymph nodes than skin are of considerable interest, especially the presence of a significant percentage of viable bacilli during reaction states when mi of skin and nerve tissue was found to be negative. evaluation of the bi's and mi's of ...	1975	1099019
the histopathology of lepromatous leprosy in the nose.	on the basis of clinical, histological and bacteriological assessments, 31 patients in central india were selected and classified as having active but early lepromatous leprosy and 4 patients as having early borderline leprosy. from the nose of each patient an average of 4 biopsies were taken from particular sites of the septum and turbinates either by punch biopsy or dissection with a scalpel. the nasal tissues from all the lepromatous patients contained many acid-fast bacilli; no bacilli or ab ...	1975	1099180
a simplification of the mouse foot-pad infection using mycobacterium leprae from skin scrapes.		1975	1099371
field workers' forum. biopsies in leprosy.		1975	1099373
letter: nasal mucosa as the portal exit of mycobacterium leprae.		1975	1099374
cytochrome pigments in mycobacterium leprae isolated from armadillos (dasypus novemcinctus l.).	the bacilli were isolated from granulomata harvested from armadillos. cytochrome systems in whole cell suspensions as well as in cell-free extracts were examined spectrophotometrically. the intact cells contained cytochromes of the a+b3, b and c type which were found to be present mainly in the reduced form. the cytochrome systems in cell-free extracts of m. leprae were in the oxidized form but contained the same type of cytochromes as the intact bacteria. the presence of cytochromes was easily ...	1975	1099400
[microbiology of leprosy. is there an in-vitro cultivable phase of hansen's bacillus].		1975	1099992
rifampicin: the investigation of a bactericidal antileprosy drug.		1975	1100951
the use of rifampicin in the treatment of leprosy.		1975	1100952
the effect of a single dose of rifampicin on the infectivity of the nasal discharge in leprosy (preliminary communication).		1975	1100954
clinical and bacteriological effects of rifampicin in combination with l73a in leprosy: observation for six months.		1975	1100957
chemotherapeutic trials in patients with non-lepromatous leprosy.		1975	1100965
viability of myco. leprae in the skin and bone marrow of patients with lepromatous leprosy while on dapsone or lamprene.		1975	1100966
effect of mono treatment and combined treatment on the morphology of myco. lepare in the skin.		1975	1100967
treatment of leprosy with clofazimine, rifampicin and bayrena.		1975	1100968
low dose dapsone therapy in lepromatous leprosy.		1975	1100970
minimal inhibitory dosage of rifampicin in intermittent treatment of mycobacterium leprae infection in mice.	the total minimal inhibitory dose of rifampicin determined in the experimental mouse model, was found to be 10 mg/kg body weight, administered once a week for 6 weeks or once every 2 weeks for 12 weeks. from these and other results it is suggested that administration of rmp in human treatment can be reduced to a total amount of 7.2 either as a 600 mg dose once a week for 12 weeks or as a 900 mg dose once a week for 8 weeks. at present these regimens can only be used as an introductory treatment ...	1975	1101580
effect of microbial substances of different origins on the growth of mycobacterium leprae.	mycobacterium leprae multiplied in media enriched with substances originating from other mycobacteria, from non-acid-fast actinomycetales or from gram-positive or gram-negative eubacteriales. most of the m. leprae strains did not grow on a synthetic medium containing the amino acids present in m. smegmatis, but the growth-promoting effect of sonic extracts of this organism indicated that substances of bacterial origin, other than amino acids, do act as growth factors. the identification of the g ...	1975	1102491
the treatment of tuberculosis and leprosy.		1975	1102829
failure of levamisole to alter the lepromin reaction.	in a study of 37 leprosy patients, the oral administration of levamisole failed to provoke an increase in both the fernandez and mitsuda reactions to lepromins of human and armadillo origin. we interpret this as evidence against an effective specific immunostimulatory capability of levamisole in leprosy patients under the conditions of the study. current knowledge of the mechanism of levamisole action supports the concept that the fundamental immunologic defect in lepromatosus leprosy may reside ...	1975	1103643
repeated tissue sampling with a dental broach. a trial in cutaneous leishmaniasis.	a simple and almost painless technique for repeated sampling of dermal infiltrates with a dendritic broach was used in the diagnosis of cutaneous leishmaniasis. this technique can be used to advantage to obtain organisms and cell underneath crusted lesions and to evaluate not only the number of organisms but also the cell pattern at different depths of the lesion. it can be used repeatedly on the same lesions without appreciably disturbing the natural progress of the disease and is therefore wel ...	1975	1103933
effect of thymectomy and antilymphocyte serum on mycobacterium leprae infection in mice.	balb/c mice thymectomized at 3 to 5 days of age were studied to determine if this procedure would result in enhanced susceptibility to infection with mycobacterium leprae and, if so, whether or not administration of antilymphocyte serum would further increase this susceptibility. the plateau for growth in the footpads of intact mice occurred 4 months after inoculation, whereas in the thymectomized and thymetocomized plus antilymphocyte serum-treated groups the plateau occurred between months 11 ...	1975	1104476
evaluation of "chemical isolation" in 1,168 leprosy patients' homes.	"chemical isolation" (treatment of open cases as a measure of control for transmission between contacts) is evaluated by a retrospective study of 7,232 household contacts of 1,168 leprosy patient homes. contacts comparable in age and type of exposure were arranged in subgroups according to whether they were born before (group a) or born after (group b) beginning treatment of the index cases had begun. additionally, the whole group of contacts, both of open (ll & bb) and closed (tt & i) cases wer ...	1975	1104496
dapsone metabolism in patients with dapsone-resistant leprosy.		1975	1106232
lepromatous leprosy in the nose after one year of dapsone treatment: clinical and bacteriological findings.		1975	1107725
lepromatous leprosy in the nose after one year of dapsone treatment: histopathological findings.		1975	1107726
the fly as potential vector in the transmission of leprosy.		1975	1107727
multicentre controlled comparative trial of clofazimine and dapsone in low dosages.		1975	1107728
importance of nasal lesions in early lepromatous leprosy.	there are some 20 million people in the world with leprosy. in the lepromatous form of the illness the nose becomes infected very early in the disease process. the nasal discharge which occurs is heavily bacillated and is the most potent source of exit of mycobacterium leprae from the body. the necessity for early diagnosis and treatment of leprosy in the absence of an effective vaccine is discussed and the pathological changes that occur in the nose are outlined. the roles which the leprologist ...	1975	1108744
minimal inhibitory concentration of dapsone for mycobacterium leprae in rats.	to define the minimal inhibitory concentration (mic) of dapsone (dds) for mycobacterium leprae in rats, we determined the relationship between dietary and plasma levels of dds in uninfected male and female lewis rats. this knowledge was applied to the design of experiments using rats inoculated in the footpads with m. leprae. the mic for dds in male and female rats, respectively, was 1.5 to 4.0 ng and 1.8 to 3.0 ng of dds/ml of plasma, even though the sexes exhibited markedly different concentra ...	1975	1108776
polymorphonuclear activation in leprosy. i. spontaneous and endotoxin-stimulated reduction of nitroblue tetrazolium: effects of serum and plasma on endotoxin-induced activation.	spontaneous nitroblue tetrazolium (nbt) reduction was evaluated in neutrophils from patients with the different types and forms of leprosy, and compared with reduction obtained form cells from normal controls. leucocytes from the same subjects were stimulated in vitro by endotoxin, and the rise in percentage of cells reducing nbt was determined. patients of all groups, with the exception of those with reactional lepromatous leprosy (rll) had an essentially normal proportion of reducing cells. ne ...	1975	1212808
comparison of reactions to human and armadillo lepromins in leprosy.	to assess the usefulness of mycobacterium leprae-infected armadillo tissue as a substitute for human lepromas for the manufacture of lepromin, we compared skin reactions to preparations from these two sources in 115 leprosy patients. the patient sample represented all the primary clinical forms of leprosy. lepromin derived from the armadillo (lepromin-a) provoked the same pattern of responses as human derived lepromin (lepromin-h), i.e., lepromatous patients gave the weakest reactions. lepromin- ...	1975	1240870
[reactional status of leprosy].	reactional leprosy is studied according to its clinical forms a) lepromatous a) acute lepromatization: encroaching and invasive nature; the patient becomes more and more lepromatous ; bad prognosis. b) erythema nodosum: "contusiform dermatitis"; variable prognosis not so bad as it is in the preceding case; allergic nature and its evolution is usually detained and therapeutics efficient. c) erythema multiform. d) lucio's phenomenon: vascular lesions and consequently necrosis as a complication of ...	1975	1241072
[leprosy].		1974	4595692
impact of cool temperatures on transformation of human and armadilio lymphocytes (dasypus novemcinctus, linn.) as related to leprosy.		1974	4596004
the nasal discharge in leprosy.		1974	4596613
genitourinary leprosy.		1974	4596831
intra-axonal bacilli in lepromatous leprosy. a light and electron microscopic study.		1974	4597056
the rate of bactericidal action of rifampin on mycobacterium leprae in the mouse footpad.		1974	4597278
skin, dartos, and nerve biopsies as aids to diagnosis in leprosy.		1974	4598943
development of an established cell line derived from dasypus novemcinctus (armadillo), a laboratory animal susceptible to infection by mycobacterium leprae.		1974	4599002
the result of inoculation of mycobacterium leprae in the goldfish (carassius auratus).		1974	4599823
uptake of radioactive dopa by m. leprae.		1974	4600624
trophic skin ulceration of leprosy: skin and serum zinc concentrations.	skin and serum zinc measurements have been made in patients with leprosy with and without trophic skin ulceration and in several other groups. serum zinc concentrations were decreased in leprosy irrespective of the presence or absence of skin ulceration. serum zinc concentrations in leprosy were also unrelated to smears positive for mycobacterium leprae and to the clinical type of leprosy. since a decrease of the serum zinc was also found in patients with dermatitis herpetiformis and pulmonary t ...	1974	4601207
a light and electron microscopic study of peripheral nerves in an armadillo with disseminated leprosy.		1974	4617714
effects of the administration of b663 [g 30 320, lamprene, clofazimine (geigy)] on three groups of lepromatous and borderline of leprosy.		1974	4617715
minimum inhibitory and bactericidal dosages of rifampici against mycobacterium leprae in the mouse foot pad: relationship to serum rifampicin concentrations.		1974	4617716
controlled long-term therapy of leprosy with b663 (lamprene, clofazimine) compared with dds.		1974	4617720
lepromin retesting as a factor of lepromin test positivation.		1974	4617721
leprosy of the nose clinical reassessment.		1974	4617723
letter: lepromin nomenclature.		1974	4617726
[experimental transmission of m. leprae in the testis of mice, born from 131i-injected females (author's transl)].		1974	4618883
elimination of mycobacterium leprae subsequent to local in vivo activation of macrophages in lepromatous leprosy by other mycobacteria.		1974	4619359
[tropism of mycobacterium leprae for the nevis cells].		1974	4619901
survival of mycobacterium leprae in newborn rat heart cell culture.		1974	4620142
editorial: prevention of leprosy.		1974	4598138
the occurrence of mycobacterium leprae within axons of peripheral nerves.		1974	4601761
mycolic acids from "noncultivable" mycobacteria.	chromatographic analysis, coupled to mass spectrometry with a high-resolution mass spectrometer, of materials isolated from skin lesions of patients with lepromatous leprosy allows the recognition of characteristic mycobacterial products, mycolic acids. this finding indicates that the "noncultivable" bacteria responsible for leprosy are mycobacteria.	1974	4601900