Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| bovine milk antibodies for health. | the immunoglobulins of bovine colostrum provide the major antimicrobial protection against microbial infections and confer a passive immunity to the newborn calf until its own immune system matures. the concentration in colostrum of specific antibodies against pathogens can be raised by immunising cows with these pathogens or their antigens. immune milk products are preparations made of such hyperimmune colostrum or antibodies enriched from it. these preparations can be used to give effective sp ... | 2000 | 11242458 |
| [value of antibiotype and bacteriocinotype for differentiating shigella strains isolated in argentina]. | the aim of the present work was to analyse the phenotypical characteristics of shigella strains in order to evaluate their possible utilisation as epidemiological markers. for one year, we studied 95 strains of shigella obtained from stool specimens of patients with dysentery. bacteria came from various health care centres in the states of chaco and corrientes (argentina). bacteria were identified by using classical biochemical methods. all strains were serotyped and susceptibility patterns were ... | 2000 | 11775312 |
| src tyrosine kinase activity down-regulates rho-dependent responses during shigella entry into epithelial cells and stress fibre formation. | invasion of epithelial cells by shigella, the causative agent of bacillary dysentery, is dependent upon the formation of characteristic membrane ruffles that engulf the bacteria in a macropinocytic-like process. we show here that cdc42 and rac gtpases, but not rho;, are critical for actin polymerisation, whereas rho; is necessary for the recruitment of ezrin and src at the site of entry. remarkably, cells expressing constitutively active src did not show ezrin recruitment at shigella entry foci. ... | 2000 | 10591626 |
| interaction of enteropathogenic or enterohemorrhagic escherichia coli with hela cells results in translocation of cortactin to the bacterial adherence site. | infection of cultured hela epithelial cells with enteropathogenic escherichia coli (epec) or enterohemorrhagic e. coli (ehec) o157:h7 results in accumulation of cortactin under the adherent bacteria. tyrosine phosphorylation of cortactin is not induced following hela cell infection with ehec or epec, contrary to what has been reported to occur with shigella flexneri. | 2000 | 10603412 |
| i-ceui fragment analysis of the shigella species: evidence for large-scale chromosome rearrangement in s. dysenteriae and s. flexneri. | i-ceui fragments of four shigella species were analyzed to investigate their taxonomic distance from escherichia coli and to collect substantiated evidence of their genetic relatedness because their ribosomal rna sequences and similarity values of their chromosomal dna/dna hybridization had proved their taxonomic identity. i-ceui digestion of genomic dnas yielded seven fragments in every species, indicating that all the shigella species contained seven sets of ribosome rna operons. to determine ... | 2000 | 10612738 |
| serotype-converting bacteriophages and o-antigen modification in shigella flexneri. | o-antigen modification (serotype conversion) in shigella flexneri, which is an important virulence determinant, is conferred by temperate bacteriophages. several serotype-converting phages have been isolated and preliminary characterization has identified the genes involved in o-antigen modification, and has also provided insight into the molecular biology of these phages. | 2000 | 10637639 |
| effect of erythromycin on shigella infection of caco-2 cells. | erythromycin (em), one of the macrolides, shows a dose-dependent effect on shigella flexneri invasion of caco-2 cells even at concentrations less than the minimum inhibitory concentration (submic). ls13, a strain of s. flexneri 1b, invaded caco-2 cells in vitro. when the strain was treated with submic of em, the invasion efficiency decreased. the carrier rate of the invasion plasmid containing virulence genes was reduced by em treatment, as determined by the colony pigmentation test on congo red ... | 2000 | 10640609 |
| identification of a novel genetic locus that is required for in vitro adhesion of a clinical isolate of enterohaemorrhagic escherichia coli to epithelial cells. | enterohaemorrhagic escherichia coli (ehec) are food-borne intestinal pathogens with a low infectious dose. adhesion of some ehec strains to epithelial cells is attributed, in part, to intimin, but other factors may be required for the intestinal colonizing ability of these bacteria. in order to identify additional adherence factors of ehec, we generated transposon mutants of a clinical ehec isolate of serotype o111:h-, which displayed high levels of adherence to cultured chinese hamster ovary (c ... | 2000 | 10652089 |
| e. coli hemolysin e (hlye, clya, shea): x-ray crystal structure of the toxin and observation of membrane pores by electron microscopy. | hemolysin e (hlye) is a novel pore-forming toxin of escherichia coli, salmonella typhi, and shigella flexneri. here we report the x-ray crystal structure of the water-soluble form of e. coli hlye at 2.0 a resolution and the visualization of the lipid-associated form of the toxin in projection at low resolution by electron microscopy. the crystal structure reveals hlye to be the first member of a new family of toxin structures, consisting of an elaborated helical bundle some 100 a long. the elect ... | 2000 | 10660049 |
| shigella flexneri 2a strain cvd 1207, with specific deletions in virg, sen, set, and guaba, is highly attenuated in humans. | a phase 1 clinical trial was conducted among 35 healthy adult volunteers to evaluate the safety, immunogenicity, and shedding of different doses of cvd 1207, a live attenuated shigella flexneri 2a vaccine candidate with specific deletion mutations in virg, sen, set, and guaba. cvd 1207 retains the ability to invade epithelial cells but cannot effectively spread intercellularly after invasion (deltavirg), does not produce enterotoxin (deltasen and deltaset), and has limited proliferation in vivo ... | 2000 | 10678904 |
| induction of necrosis in human neutrophils by shigella flexneri requires type iii secretion, ipab and ipac invasins, and actin polymerization. | infection by shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. although neutrophils are constitutively programmed to die by apoptosis, we show that isolated human neutrophils undergo necrosis 2 h after infection with virulent s. flexneri strain m90t but not with the virulence plasmid-cured strain bs176. this was demonstrated by the release of azurophil granule proteins concomitant with the release of lactate dehydrog ... | 2000 | 10678940 |
| evaluation of antibacterial activity of asparagus racemosus willd. root. | different concentrations (50, 100, 150 microg/ml) of the methanol extract of the roots of asparagus racemosus willd. showed considerable in vitro antibacterial efficacy against escherichia coli, shigella dysenteriae, shigella sonnei, shigella flexneri, vibrio cholerae, salmonella typhi, salmonella typhimurium, pseudomonas putida, bacillus subtilis and staphylococcus aureus. the effects produced by the methanol extract were compared with chloramphenicol. | 2000 | 10685109 |
| transfer rna modification, temperature and dna superhelicity have a common target in the regulatory network of the virulence of shigella flexneri: the expression of the virf gene. | full expression of the virulence genes of shigella flexneri requires the presence of two modified nucleosides in the trna [queuosine, q34, present in the wobble position (position 34) and 2-methylthio-n6-isopentenyladenosine (ms2i6a37, adjacent to and 3' of the anticodon)]. the synthesis of these two nucleosides depends on the products of the tgt and miaa genes respectively. we have shown that the intracellular concentration of the virulence-related transcriptional regulator virf is reduced in t ... | 2000 | 10692168 |
| construction of an efficient expression system for agrobacterium tumefaciens based on the coliphage t5 promoter. | a versatile expression vector utilizing a promoter of coliphage t5, p(n25) (gentz and bujard, 1985. j. bacteriol. 164, 70-77) and a derivative of the incw broad-host-range plasmid pjb20 (beaupré et al., 1997. j. bacteriol. 179, 78-89) has been developed. this vector successfully expresses virulence proteins of agrobacterium tumefaciens encoded by virg and a mutant allele of vira, vira (delta1-284, g665d) in escherichia coli as well as in a. tumefaciens. the signal transduction proteins vira (del ... | 2000 | 10721702 |
| emergence of antimicrobial-resistant shigellosis in oregon. | ampicillin and trimethoprim-sulfamethoxazole (tmp-smz) are currently considered acceptable empirical therapy for shigellosis in developed countries. however, there are few recently reported studies on antimicrobial resistance among shigellae isolated in the united states. we examined the epidemiology of shigellosis and the antimicrobial susceptibility of shigella species isolated in oregon from july 1995 through june 1998. of 430 isolates, 410 were identified to the species level: shigella sonne ... | 2000 | 10722437 |
| clostridium difficile recombinant toxin a repeating units as a carrier protein for conjugate vaccines: studies of pneumococcal type 14, escherichia coli k1, and shigella flexneri type 2a polysaccharides in mice. | unlike the native protein, a nontoxic peptide (repeating unit of the native toxin designated raru) from clostridium difficile toxin a (cdta) afforded an antigen that could be bound covalently to the surface polysaccharides of pneumococcus type 14, shigella flexneri type 2a, and escherichia coli k1. the yields of these polysaccharide-protein conjugates were significantly increased by prior treatment of raru with succinic anhydride. conjugates, prepared with raru or succinylated (rarusucc), were a ... | 2000 | 10722615 |
| shigella actin-based motility in the presence of truncated vinculin. | mounting evidence supports the role of truncated vinculin in the intracellular actin-based motility of shigella flexneri. vinculin's role was recently questioned by goldberg [1997: cell motil cytoskeleton 37:44-53] who observed shigella motility in mouse embryonal carcinoma 5.51 cells, a genetically modified cell line that reputedly lacked vinculin. that challenge implicitly relied on the assumption that 5.51 cells had no detectable vinculin polypeptide and lacked full-length vinculin mrna. desp ... | 2000 | 10744860 |
| antimicrobial resistance trends in shigella serogroups isolated in israel, 1990-1995. | from a total of 31319 shigella strains isolated in israel between 1990 and 1996, 17574 were sent to the national shigella reference center for typing. of these, 15287 were identified as shigella sonnei, 1833 as shigella flexneri, 327 as shigella boydii and 127 as shigella dysenteriae. in all, 4395 strains were tested for sensitivity to ampicillin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, nalidixic acid and ofloxacin. all strains tested were sensitive to ofloxacin, and only t ... | 2000 | 10746496 |
| antagonistic effect of lactobacillus acidophilus, saccharomyces boulardii and escherichia coli combinations against experimental infections with shigella flexneri and salmonella enteritidis subsp. typhimurium in gnotobiotic mice. | lactobacillus acidophilus, saccharomyces boulardii and escherichia coli are probiotic strains used individually to protect against enteropathogenic agents. in order to determine if a synergistic effect of the individual protective mechanisms ordinarily attributed to each of these biotherapeutic agents is possible, we orally administered lact. acidophilus h2b20, s. boulardii and e. coli emo (lse) to germfree mice. ten days after colonization of the digestive tract, groups of animals associated (e ... | 2000 | 10747216 |
| [antimicrobial resistance of shigella spp. in córdoba, argentina, during the period 1990-1997]. | this study analyzed the evolution of antimicrobial resistance in 771 isolates of shigella spp. obtained from a total of 9,195 feces cultures done between 1990 and 1997 in a children's hospital in córdoba, argentina. s. flexneri, which was responsible for 73% of the shigella infections, was the species with the greatest resistance. the frequency of s. flexneri resistance to the three antibiotics most used (ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol) increased from 10% in 1990 ... | 2000 | 10748662 |
| [erythromycin sensitivity of shigella flexneri and s. sonnei]. | 2000 | 10756447 | |
| the stability region of the large virulence plasmid of shigella flexneri encodes an efficient postsegregational killing system. | the large virulence plasmid pmysh6000 of shigella flexneri contains a determinant that is highly effective in stabilizing otherwise unstable plasmids in escherichia coli. expression of two small contiguous genes, mvpa and mvpt (formerly termed stborf1 and stborf2), was shown to be sufficient for stability. mutations in mvpt abolished plasmid stability, and plasmids expressing only mvpt killed the cells unless mvpa was supplied from a separate plasmid or from the host chromosome. when replication ... | 2000 | 10762240 |
| complete nucleotide sequence of tn10. | the complete nucleotide sequence of tn10 has been determined. the dinucleotide signature and percent g+c of the sequence had no discontinuities, indicating that tn10 constitutes a homogeneous unit. the new sequence contained three new open reading frames corresponding to a glutamate permease, repressors of heavy metal resistance operons, and a hypothetical protein in bacillus subtilis. the glutamate permease was fully functional when expressed, but tn10 did not protect escherichia coli from the ... | 2000 | 10781570 |
| detection of pcr products of the ipah gene from shigella and enteroinvasive escherichia coli by enzyme linked immunosorbent assay. | pcr techniques applied to diarrheal stools reliably diagnose shigella and enteroinvasive escherichia coli (eiec) infections. identification of pcr products using agarose gel electrophoresis (age) and hybridization with dna probes has several shortcomings. automated methods of identifying pcr products that process larger numbers of specimens can facilitate epidemiologic studies and standardize results. in this study, we used elisa following pcr to detect ipah gene sequences of shigella and eiec f ... | 2000 | 10794934 |
| a high incidence of shigella-induced arthritis in a primate species: major histocompatibility complex class i molecules associated with resistance and susceptibility, and their relationship to hla-b27. | the human major histocompatibility complex (mhc) class i gene, hla-b27, is a strong risk factor for susceptibility to a group of disorders termed spondyloarthropathies. rodents that express hla-b27 develop spondyloarthropathies, implicating hla-b27 in the etiology of these disorders. to determine whether an hla-b27-like molecule was associated with spondyloarthropathies in nonhuman primates, we analyzed the mhc class i cdnas expressed in a cohort of rhesus macaques that developed reactive arthri ... | 2000 | 10803844 |
| shigella flexneri ipah(7.8) facilitates escape of virulent bacteria from the endocytic vacuoles of mouse and human macrophages. | the behavior of shigella flexneri ipah mutants was studied in human monocyte-derived macrophages (hmdm), in 1-day-old human monocytes, and in j774 mouse macrophage cell line. in hmdm, strain pwr700, an ipah(7.8) deletion mutant of s. flexneri 2a strain 2457t, behaved like the wild-type strain 2457t. this strain caused rapid host cell death by oncosis, and few bacterial cfu were recovered after incubation in the presence of gentamicin as previously described for 2457t-infected hmdm. however, anal ... | 2000 | 10816519 |
| interaction of shigella flexneri ipac with model membranes correlates with effects on cultured cells. | invasion of enterocytes by shigella flexneri requires the properly timed release of ipab and ipac at the host-pathogen interface; however, only ipac has been found to possess quantifiable activities in vitro. we demonstrate here that when added to cultured cells, purified ipac elicits cytoskeletal changes similar to those that occur during shigella invasion. this ipac effect may correlate with its ability to interact with model membranes at physiological ph and to promote entry by an ipac mutant ... | 2000 | 10816532 |
| curli loci of shigella spp. | an unstable chromosomal element encoding multiple antibiotic resistance in shigella flexneri serotype 2a was found to include sequences homologous to the csg genes encoding curli in escherichia coli and salmonella enterica serovar typhimurium. as curli have been implicated in the virulence of serovar typhimurium, we investigated the csg loci in all four species of shigella. dna sequencing and pcr analysis showed that the csg loci of a wide range of shigella strains, of diverse serotypes and diff ... | 2000 | 10816548 |
| matrix-assisted laser desorption/ionization time-of-flight mass spectrometric detection of bacterial biomarker proteins isolated from contaminated water, lettuce and cotton cloth. | matrix-assisted laser desorption/ionization time-of-flight (maldi-tof) mass spectra of bacterial proteins were obtained from water, lettuce and cloth samples contaminated with shigella flexneri, escherichia coli, and aeromonas hydrophila. spectra were obtained using proteins directly isolated from water (or water used for rinsing samples) without culturing the bacteria. for s. flexneri and e. coli, two marker ions for specific proteins associated with a virulence-related property (acid resistanc ... | 2000 | 10825256 |
| rho family gtpase cdc42 is essential for the actin-based motility of shigella in mammalian cells. | shigella, the causative agent of bacillary dysentery, is capable of directing its movement within host cells by exploiting actin dynamics. the virg protein expressed at one pole of the bacterium can recruit neural wiskott-aldrich syndrome protein (n-wasp), a downstream effector of cdc42. here, we show that cdc42 is required for the actin-based motility of shigella. microinjection of a dominant active mutant cdc42, but not rac1 or rhoa, into swiss 3t3 cells accelerated shigella motility. in add-b ... | 2000 | 10839806 |
| caspase-1 activation of il-1beta and il-18 are essential for shigella flexneri-induced inflammation. | caspases are intracellular proteases that mediate mammalian cell apoptosis. caspase-1 (casp-1) is a unique caspase because it activates the proinflammatory cytokines interleukin (il)-1beta and il-18. shigella flexneri, the etiological agent of bacillary dysentery, induces macrophage apoptosis, which requires casp-1 and results in the release of mature il-1beta and il-18. here we show that casp-1(-/-) mice infected with s. flexneri do not develop the acute inflammation characteristic of shigellos ... | 2000 | 10843390 |
| disease-dependent changes in t-cell populations in patients with shigellosis. | in shigellosis, bacterial infection is associated with an extensive inflammation of the rectal mucosa, resulting in bloody dysentery. the role of t-cell-mediated pro-inflammatory mechanisms has been implicated in this process, but the specific role of t-cell subsets is still not well understood. in this study we attempted to identify the changes in t-cell populations in patients with shigellosis during the disease course. the t-cell subset distribution was analyzed by immunohistochemistry in the ... | 2000 | 10843411 |
| [infections of the airways--when are antibiotics indicated?]. | 2000 | 2193309 | |
| antigen recognition in the gastrointestinal tract: death to the dogma. | 2000 | 1955758 | |
| workshop report from the division of research grants, national institutes of health. molecular genetic approaches to the analysis of malignant transformation--a pathology b study section workshop. | 2000 | 1692768 | |
| [summary of air pollutant levels at the three locations of the national autoexhaust monitoring station in tokyo from january to december 1977 (author's transl)]. | 2000 | 86369 | |
| effects of blood glucose concentration on thermogenesis and glucose disposal during hyperinsulinaemia. | 1. the thermogenic and cardiovascular responses to glucose ingestion or infusion are altered by undernutrition. these changes may be due, in part, to alterations in the blood glucose concentration. this study investigates the effect of variation in the blood glucose concentration on the thermogenic and cardiovascular responses to a hyperinsulinaemic glucose clamp. 2. ten healthy post-absorptive subjects (six male, aged 21-30 years) were studied on two occasions. baseline measurements were made f ... | 2000 | 2169378 |
| [prevalence study on dementia and alzheimer disease]. | an epidemiological survey on dementia and alzheimer disease (ad) was carried out in a community of 5055 persons over the age of 55 at jingan district of shanghai. diagnoses were made according to the diagnostic criteria of dementia of dsm-iii-r and of ad of nincds-adrda. it was found that dementia is not uncommon in the aged, and ad was the leading category of dementia. the age and sex adjusted prevalence rate of dementia was 2.57% in those over 55, 3.46% in those over 60, and 4.61% in those ove ... | 2000 | 2174278 |
| hla frequencies in a mexican mestizo population. | the aim of the present study was to reevaluate the distribution of hla antigens in mexican mestizos since, in our previous report, very few specificities were explored for this population. the mestizos are primarly a mixture of caucasians (spaniards) and mexican indians and account at the present time for about 95% of the total mexican population. a and b antigens were typed on isolated cells using a microlymphocytotoxicity technique. antigen, gene and haplotype frequencies were calculated inclu ... | 2000 | 94707 |
| home health agencies and community nursing services accredited by nln/apha, september 1979. | 2000 | 384368 | |
| plasma levels of d-amphetamine in hyperactive children. serial behavior and motor responses. | amphetamine has been clearly documented to be an efficacious treatment for hyperactive children. the pharmacokinetics of amphetamine have been studied in adults, but not in children. sixteen male children who scored greater than 2sd from norms on factors i and iv of conner's teacher rating scale and who were not excluded for reasons to do with medical or psychiatric conditions, intelligence, or age, had a plasma d-amphetamine apparent elimination half-life of 6.8 +/- 0.5h. peak plasma level occu ... | 2000 | 111276 |
| pre-operative assessment of biliary tract surgery. | 2000 | 97782 | |
| [comparative nutrition studies on 4 l-amino acid solutions in 25 metabolically healthy adults under conditions of total parenteral alimentation]. | 2000 | 97219 | |
| [use of discounting and other characteristics of the economic assessment of medical measures]. | 2000 | 111356 | |
| epidemiology of multiple drug use with special reference to phencyclidine. | 2000 | 101866 | |
| maternal and neonatal risk at caesarean section. | 2000 | 15786 | |
| environmental cancer: a report to the public, cost benefit/risk assessment. | 2000 | 111367 | |
| the repair of radiation damage in drosophila melanogaster. | 2000 | 97729 | |
| [metabolic activation of carcinogenic n-nitrosodialkylamines]. | chemical and biological properties of metabolically activated species of carcinogenic n-nitrosodialkylamines are reviewed. alpha-hydroxy nitrosamines and their derivatives; alpha-acetoxy nitrosamines, alpha-hydroperoxy nitrosamines, alpha-phosphonooxy nitrosamines and alkanediazotates are included. metabolic deactivation through denitrosation and metabolic activation through beta-oxidation are also mentioned. | 2000 | 2213524 |
| [a desire for better nursing - hardship and problems shared by fellow nurses]. | 2000 | 97446 | |
| [induction and reversibility of surface events by deprivation and refeeding with vitamin b12 in euglena gracilis]. | 2000 | 101678 | |
| [oral long-term iron therapy without problems]. | 2000 | 101734 | |
| the elemental diet. | 2000 | 97415 | |
| [long term disodium-cromoglycate treatment in children with bronchiale asthma who responded unsatisfactorily to hyposensitation (author's transl)]. | the authors treated 53 asthmatic children for 1/2 to 2 years with disodium-cromoglycate (intal). the patients were selected of 412 children suffering of bronchial asthma. the patients were living at home and controled by the outpatient consultation of the hospital. the criteria of selection were: 1. failure of hyposensitization-treatment, or symptomatic therapy. 2. polysensibilisation. 3. anaphylactic shock. 4. lack of positive skin tests to allergen extracts ("endogenous asthma"). 40 patients g ... | 2000 | 97517 |
| [acylase activity of mycophilic fungi]. | the acylase activity was studied with 65 cultures of mycophilic fungi belonging to 56 species and 33 genera. among these: 9 species displayed the acylase activity toward ampicillin; 8 species, toward phenoxymethylpenicillin; 6 species, toward benzylpenicillin; and 21 species manifested the complex activity. many of the active species belonged to the bionecrotrophic group of mycophilic fungi, the number of necrotrophic fungi was less, while that of biotrophs and saprotrophs was even lower. | 2000 | 97501 |
| the results of basal and post pentagastrin gastric secretory studies in apparently healthy subjects, a preliminary communication. | pentagastrin stimulated gastric secretory studies were carried out in 26 apparently healthy subjects. each specimen of gastric juice was analysed for volume, ph, total acidity and major electrolytes. the data was analysed and compared with other published reports. | 2000 | 97409 |
| risk to the new-born from caesarean section. | 2000 | 15785 | |
| review of laxative utilization in a skilled nursing facility. | laxatives are the most frequently prescribed drugs in long-term care facilities. of all nursing home patients, 58 percent receive laxatives--often more than one, and usually on a "prn" basis. this pattern of dosage is probably used in an effort to prevent constipation. selection of a laxative should be based on careful evaluation of the cause of constipation, with due consideration being given to differences in drug effectiveness and the incidence of side effects. a review of laxative utilizatio ... | 2000 | 101574 |
| [interstitial nephropathies]. | 2000 | 101798 | |
| a study of blood utilization by diagnosis, month of transfusion, and geographic region of the united states. | the purpose of this study was to analyze blood utilization by 92,815 transfused patients treated in 300 united states hospitals during 1974. in order to achieve this end, transfused patients were first divided into 349 diagnosis groups. blood transfusion data for the highest ranking 50 groups in terms of total units administered to patients in the group are presented and discussed, as well as the blood needs of patients in 19 major disease categories such as malignant neoplasm. blood transfusion ... | 2000 | 92077 |
| [pure acute monocytic leukaemia: morphological, cytochemical and clinical study of 14 cases (author's transl)]. | 2000 | 98400 | |
| microbial invasion--the major ally of war (natural biological warfare). | 2000 | 97578 | |
| automated multiphasic health tests. | 2000 | 97506 | |
| weight, height and arm circumference of a group of low income esfahan children. | 2000 | 97397 | |
| nasogastric intubation technique for bile sampling in the baboon (papio ursinus). | a duodenal tube was introduced into the duodenum of the fasted baboon via the nasal passage. after the application of vacuum for several minutes, the baboon received an intravenous injection of pancreozymin and cholecystokinin which caused contraction of the gall bladder. aspiration of the bile sample was carried out via the duodenal tube. | 2000 | 110980 |
| [economic crisis in public health in the capitalist countries]. | 2000 | 97790 | |
| some factors, influencing the sensitivity of the antibody screening the groupamatic 360 system. | 2000 | 97759 | |
| [problems of electrocardiographic and vectorcardigoraphic diagnosis in postero-basal myocardial infarct and in right branch block]. | 2000 | 97684 | |
| [relations between myopia, education and intelligence]. | 2000 | 2189811 | |
| [determination of serum digitoxin by means of a solid-phase enzyme-linked immunosorbent assay (author's transl)]. | a solid-phase elisa-technique for clinical applications is described. it requires little apparatus other than a photometer and allows the rapid determination of serum digitoxin levels. it differs from the original technique only in the sample volume being smaller and a digitoxin calibration curve being required. concurrent assays by a reference method (86rb-erythrocyte assay) gave results in excellent agreement with the values obtained by the modified elisa-technique on samples from patients und ... | 2000 | 111013 |
| [the role of tuberculin test and fluoroscopy in detecting intra- thoracic tuberculosis in children and adolescents living in the rural area with high incidence of tuberculosis]. | the analysis of 91 case records of children and adolescents living in rural area with a high incidence of tuberculosis was made. these patients were detected through screening and by means of tuberculin diagnosis and fluorography carried out by a team of health workers on a case-finding mission. the organization of work with due regard for the local conditions makes it possible to use the above methods for an early detection of the given disease; to assess the results obtained from the very begi ... | 2000 | 2150699 |
| [effects of hypertrophy on cardiac systolic and diastolic performance in athletes with mild hypertension]. | aims of the study has been the evaluation of morphological and functional aspects of left ventricle in subjects undergoing mild hypertension and sport adaptation effects. these evaluations have been carried out by echo-doppler both at rest and during sharp increase in after load induced by isometric stress. together with the morphological parameters represented by mass index and by radius to thickness ratio, we have studied stroke volume and transmitral flow pattern assessing the maximum flow ve ... | 2000 | 2150692 |
| [treatment of waldenström's macroglobulinaemia with high-doses cyclic corticosteroids (author's transl)]. | 2000 | 111359 | |
| [catheter infection in subclavian vein puncture]. | 2000 | 101801 | |
| [muscle blood flow and capillary diffusion capacity in patients with rheumatoid arthritis (author's transl)]. | capillary blood flow (xenon-133) and diffusion capacity for chrom-51-edta (ps-product of renkin) of striated muscle tissue were examined by double isotope method in patients with rheumatoid arthritis. xenon-clearance and ps-product were studied under normal conditions and following hyperemisation. there existed no significant difference between rheumatoid patients and normal subjects and there was no evidence of increased capillary permeability. apparently, derangement of muscle capillaries is r ... | 2000 | 101713 |
| superoxide dismutase as a regulatory switch in mammalian testicular steroidogenesis. | the delta 4-pathway of testosterone biosynthesis in leydig cells, widely believed to proceed through pregnenolone--greater than pregnenedione--greater than progesterone route catalyzed by 5 delta-3 beta-hydroxysteroid dehydrogenase and delta 5-delta 4-isomerase respectively is shown to pass through an alternate pathway mediated by superoxide dismutase and peroxidase. a built-in regulatory switch is incorporated in this route, with the superoxide dismutase inducible upon lh-stimulation of the ley ... | 2000 | 2175181 |
| perinatal perspective: introduction to this issue of the qrb. | 2000 | 101945 | |
| ["first" and "second" generation sulfonylureas: distinction or difference? (author's transl)]. | 2000 | 98364 | |
| [keratinizing and calcifying odontogenic cyst (author's transl)]. | 2000 | 94605 | |
| natural sesquiterpenoids. | 2000 | 2193260 | |
| oral rehabilitation by prosthetic restoration after maxillectomy for malignant tumors. | in maxillectomy patients, speech intelligibility between before and after insertion of prostheses has been reviewed by many investigators. speech intelligibility was not related to the size of the defect, but rather to the defect region. speech intelligibility was considerably improved by the use of prostheses. a great difference could not be found in escape rate from the nasal cavity between before and after insertion of prostheses, but there was a remarkable change in the spirometer. postmaxil ... | 2000 | 94595 |
| [pre- and postoperative erythrocyte volume distribution curves in children with cyanotic heart defects]. | the behaviour of the volume distribution curves (vvk) of red blood cells in children with cyanosed organic heart defect is reported by taking preoperative and postoperative observations as a basis. mcv determined from the volume distribution curve amounts to 80.3 micron3. if the volume distribution curves of the preoperative patient group are compared with the postoperative patient group (4 months) by means of the criteria dsmax, ds, inclination and dispersion, no significant changes can be iden ... | 2000 | 89988 |
| control of drug self-administration: the role of aversive consequences. | 2000 | 101875 | |
| [cost and time of medical care in an out-patient-clinic (author's transl)]. | 2000 | 97650 | |
| diabetic ketoacidosis. continuous infusion of low-dose insulin. | 2000 | 97603 | |
| local control and lethal toxicity in limited small cell lung cancer. | 2000 | 2174843 | |
| [clinical biochemical aspects of the prophylaxis and therapy of senile cataract with zinc aspartate (author's transl)]. | in the aetiology and pathogenesis of senile cataract a disturbed glucose utilisation is found. this reflects a loss of activity of some key enzymes for glycolysis in the lens. these enzymes (ald, g6pdh, hk, ldh, mdh and phosphofructokinase) are zinc metal enzymes. the decrease in activity of these enzymes can be compensated by the administration of specific cations. with zinc one can improve the impaired glucose metabolism occurring in old age. for the prophylaxis and therapy of senile cataract ... | 2000 | 97466 |
| [profile of a nurse: ms. makiko nemoto, a young nurse trained in a seventh day adventists' school]. | 2000 | 97456 | |
| [emergency care and nursing. 17. tetanus, gas gangrene, foreign bodies, drowning, and electrocution]. | 2000 | 97454 | |
| interactions between pairs of dna-specific fluorescent stains bound to mammalian cells. | the interactions between dna-specific fluorescence stains complexed with mitotic chinese hamster cells were studied by spectrofluorometric and flow fluorometric techniques. the degree of binding interactions and of energy transfer between stains was determined from the intensities and shapes of fluorescence emission spectra of cells complexed with pairs of stains. the stain pairs hoechst 33258-chromomycin a3, hoechst 33258-ethidium bromide, and chromomycin a3-ethidium bromide exhibited efficient ... | 2000 | 86583 |
| intrafamilial spread of hepatitis bs antigen. | 2000 | 97419 | |
| [severely increased alpha fetoprotein and associated diseases]. | in 1977 and 1978 the serum concentration of alpha-1-fetoprotein (afp) in 3200 patients was measured for diagnostic purposes. values above 320 ng/ml were observed in 75 patients; they underwent closer study. the final diagnoses were hepatoma (50), germ cell tumors (15), other malignant tumors (6) and acute hepatitis (4). also, chronic hepatitis and liver coma may be associated with afp values above 320 ng/ml. repeated measurements usually provide further diagnostic information. | 2000 | 92051 |
| [prognosis and long term survival of intracranial aneurysms operated under hypervolemic hypotension--natural history of 104 cases of intracranial aneurysms (author's transl)]. | 2000 | 91990 | |
| [pathology of brain trauma and its clinical evaluation (author's transl)]. | 2000 | 91989 | |
| determination of fetal sex by ultrasound. | 2000 | 97313 | |
| hyponatremia. | 2000 | 97245 | |
| an estimation of dental treatment needs in two groups of refugees in sweden. | the aim of this study was to estimate dental treatment need in groups of chilean and polish refugees in sweden. of the nordic countries, sweden accepts the greatest number of refugees. an average of 5000 refugees arrived annually in 1981-85, increasing to 15,000 during 1986-87. refugees and their families now comprise 93% of non-nordic immigration. in 1981-83 a sample of 193 chilean and 92 polish refugees in the county of stockholm was selected for this study. dental treatment needs were calcula ... | 2000 | 2195841 |
| [decrease in the mutagenic effect of thiophosphamide from the action of a xyethylidene diphosphonic acid derivative]. | 2000 | 97173 | |
| effect of gonadotropin-releasing hormone on depressed mood. | 2000 | 91873 | |
| [madame g.'s hyperthyroidism]. | 2000 | 89684 |