Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [susceptibility of bacteria isolated from patients with lower respiratory tract infections to antibiotics (1986)]. | enlisting the help of various research institutions across the nation, ikemoto et al. have been pooling cultures of clinical isolates of respiratory tract infections and mapping out the correlations between patient backgrounds and the causative bacteria and the changes in the sensitivity spectra of the bacteria to various antibacterial and antibiotic agents annually since 1981. the following is a report of the 1986 findings. during the period from september, 1986 to march, 1987, 558 cases of res ... | 1989 | 2695657 |
| the prevention of severe lower respiratory infections in chronic bronchitis. | chronic bronchitis remains as a serious medical problem for many adults and a smaller proportion of children in the united states. the frequency of severe lower respiratory infections in patients with chronic bronchitis is quite variable. the infectious agents most likely responsible for severe lower respiratory disease include pneumococci, nontypable haemophilus influenza, mycoplasma pneumoniae, and branhamella catarrhalis among the bacteria, and influenza a and b viruses, with parainfluenza an ... | 1989 | 2697051 |
| [pertussis syndrome: study of 74 cases]. | pertussis syndrome controversy induced us to study 74 hospitalized patients, with pertussis cough and bordetella sp isolation in 29, other bacteria in 24 and viruses in 21. the most frequently isolated bacteria in the patients with negative culture for bordetella were haemophilus influenzae, streptococcus pneumoniae and branhamella catarrhalis. the viruses with highest incidence were respiratory syncitial viruses. the negative culture for bordetella, the lack of antibiotherapy previous to obtent ... | 1989 | 2698068 |
| differentiation of some species of neisseriaceae and other bacterial groups by dna-dna hybridization. | dna-dna hybridization using total genomic dna probes may represent a way of differentiating between miscellaneous bacterial species. this was studied with type and reference strains of 20 species in moraxella, kingella, and other selected gram-negative groups. both radioactive and biotin labelling were employed. most of the species examined were easily distinguished, such as moraxella (branhamella) catarrhalis, m.(b.) ovis, m. atlantae, m. phenylpyruvica, m. osloensis, neisseria elongata, n. men ... | 1989 | 2730785 |
| comparative in vitro activity of ciprofloxacin and other unrelated antimicrobials against bacterial respiratory tract pathogens. | ciprofloxacin is a new fluorinated 4-quinolone with a broad spectrum of antimicrobial activity which includes both gram-negative and gram-positive bacteria. in this study the in vitro activity of ciprofloxacin has been determined against bacteria associated with respiratory tract infections and compared with that of other antimicrobial agents used in the therapy of such infections. ciprofloxacin (mic90 0.008 mg/l) was highly active against haemophilus influenzae, including isolates producing bet ... | 1989 | 2737080 |
| [antimicrobial activity of cefteram comparison with other oral antibiotics]. | antimicrobacterial activities of cefteram (cftm) against clinical isolates collected in 1988 were compared with those of new beta-lactams. 1. antibacterial activities of cftm against streptococcus pneumoniae, streptococcus pyogenes, haemophilus influenzae, branhamella catarrhalis isolated from acute respiratory tract infections were 8- to 16-fold higher than those of cefaclor (ccl). 2. activities of cefixime (cfix) were superior to those of cftm against b. catarrhalis, escherichia coli, klebsiel ... | 1989 | 2746861 |
| in vitro activities of a dual-action antibacterial agent, ro 23-9424, and comparative agents. | the in vitro activity of the dual-action antibacterial agent ro 23-9424 was compared with those of cefotaxime, ceftazidime, ciprofloxacin, fleroxacin, imipenem, and amikacin against 358 aerobes and anaerobes. the mic ranges, mics for 50 and 90% of the strains (mic50s and mic90s), and percentage of strains susceptible for each agent at the recommended susceptible mic breakpoint were determined for each genus. the mic90s (micrograms per milliliter) of the agents against members of the family enter ... | 1989 | 2782857 |
| in-vitro activity of fce 22101 against respiratory tract pathogens with reference to production of beta-lactamases. | fce 22101 is a new penem with broad antibacterial spectrum, excluding the pseudomonads, and has stability to many beta-lactamases. fce 22101 and imipenem were very potent against the bacteria studied, including beta-lactamase producing strains, which can be isolated from patients with respiratory tract infections (mic less than or equal to 8 mg/l). no strains were found to be resistant to fce 22101. fce 22101 was rapidly bactericidal and more stable to inactivation by beta-lactamases from branha ... | 1989 | 2786517 |
| in-vitro activity of a new penem fce 22101. | the in-vitro activity of a new penem fce 22101 was evaluated in comparison with other antimicrobial agents against 966 aerobic and anaerobic gram-negative and gram-positive bacteria. fce 22101 inhibited 90% of enterobacteriaceae, haemophilus influenzae, h. parainfluenzae, h. ducreyi, neisseria gonorrhoeae, branhamella catarrhalis, staphylococcus aureus, staph. epidermidis and group b streptococcus at concentrations of 0.12-4.0 mg/l. pseudomonas aeruginosa was resistant with mic90 of greater than ... | 1989 | 2786518 |
| the bacteriology of acute maxillary sinusitis. | sinus secretions obtained by antral aspiration from 347 patients with acute maxillary sinusitis were examined bacteriologically. special attention was paid to the method by which anaerobic bacteria could be recovered. on the total, 485 sinus secretion samples were examined, of these 336 were aspirates, 149 yields of injection-aspirations. aerobic bacteria were cultured from 263 aspirates and from 100 injection-aspiration samples. only anaerobes were recovered from 6 sinuses. bacterial culture wa ... | 1989 | 2786617 |
| empirical treatment without bronchoscopy for pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. | an empirical approach to treating pneumocystis carinii pneumonia was adopted in a prospective study of 73 men with antibodies to human immunodeficiency virus 1 (hiv-1) presenting with respiratory problems. at presentation 49 patients (group 1) were thought to have a history, findings at clinical examination, chest radiograph, and arterial blood gas tensions typical of pneumocystis pneumonia, and empirical treatment was begun immediately. twenty four patients (group 2) were thought to have featur ... | 1989 | 2788935 |
| lomefloxacin, a new fluoroquinolone. studies on in vitro antimicrobial spectrum, potency, and development of resistance. | lomefloxacin (ny-198; sc-47111), a potent new difluoroquinolone, was studied to compare its in vitro activity with that of other antimicrobials against 2194 clinical isolates. lomefloxacin showed excellent inhibitory and bactericidal activity against strains of enterobacteriaceae and inhibited greater than 99% of the isolates at a concentration of 4 micrograms/ml or less. lomefloxacin exhibited good-to-moderate activity against strains of acinetobacter (mic90 4 micrograms/ml) and pseudomonas aer ... | 1989 | 2791485 |
| [clinical and pharmacokinetic study on cefodizime, a new cephalosporin antibiotic, in the pediatric infections]. | cefodizime (thr-221, cdzm), a new cephalosporin antibiotic, was evaluated for its safety and efficacy in 27 children with various bacterial infections. the episodes of infections included pneumonia (6 cases), bronchopneumonia (11 cases), lung abscess (1 case), acute pharyngitis (2 cases), cervical lymphadenitis (1 case), infected cephalohematoma (1 case), urinary tract infection (1 case), sepsis (2 cases) and purulent meningitis (2 cases). cdzm was effective in all but one, and its efficacy rate ... | 1989 | 2795854 |
| ticarcillin/clavulanic acid combination. treatment of bacterial infections in hospitalized children. | eighteen patients 2 months to 11 years of age with culture proven bacterial infections were treated with parenteral ticarcillin/clavulanic acid in a noncomparative study. seven patients had pneumonia, two had tracheobronchitis, three had soft tissue abscess, two had periorbital cellulitis, three had urinary tract infection and one had purulent bursitis. four of the 18 were bacteremic. organisms treated included staphylococcus aureus (6), pseudomonas aeruginosa (5), haemophilus influenzae (2), br ... | 1989 | 2805557 |
| comparative in-vitro activity of meropenem on clinical isolates from the united kingdom. | mics of meropenem were determined for a wide range of common bacteria of clinical importance. for enterobacteriaceae, aeromonas spp., haemophilus influenzae, branhamella catarrhalis, neisseria gonorrhoeae, gardnerella vaginalis, campylobacter coli/jejuni, beta-haemolytic streptococci and anaerobes other than clostridium difficile, mics were almost always within the range 0.002-0.5 mg/l. the activity of meropenem for these organisms was always greater than that of imipenem and piperacillin, and w ... | 1989 | 2808214 |
| [pharmacokinetic, bacteriological and clinical studies on cefpodoxime proxetil in the field of pediatrics]. | pharmacokinetic, bacteriological and clinical studies on cefpodoxime proxetil (cpdx-pr, cs-807), a newly developed oral cephem, were carried out in the treatment of infectious diseases in the field of pediatrics. 1. since cpdx demonstrates very powerful antimicrobial actions against such gram-negative bacilli as escherichia coli, salmonella sp., klebsiella pneumoniae and serratia sp., such gram-positive cocci as streptococcus pyogenes and streptococcus pneumoniae, and beta-lactamase producing br ... | 1989 | 2810729 |
| [laboratory and clinical studies on cefteram pivoxil in the field of pediatrics]. | laboratory and clinical studies on cefteram pivoxil(cefteram) a new cephem antibiotic, were carried out in the field of pediatrics. the results obtained are summarized as follows: 1. serum concentrations, urinary concentrations and urinary recovery rates of cefteram (cftm) were determined upon oral administration after meal of cefteram pivoxil (cftm-pi) at doses of 3 mg/kg granules in 2 cases and 6 mg/kg granules in 2. peak serum levels of cftm were obtained at 3 hours in 2 cases and 4 hours in ... | 1989 | 2810748 |
| [clinical studies on cefteram pivoxil granules in pediatrics]. | a newly developed cephalosporin, cefteram pivoxil (cftm-pi, t-2588), was evaluated clinically in 40 patients. a pharmacokinetic study was also performed with 8 patients. cftm-pi was administered as granules. one patient was given cftm-pi at a dose of 1.5 mg/kg, each of 3 patients was given the drug at a dose of 3 mg/kg and each of 4 patients at a dose of 6 mg/kg. in most cases, serum concentrations of cftm were determined at 2, 3, 4, and 6 hours after dosing. urinary concentrations of cftm were ... | 1989 | 2810757 |
| branhamella catarrhalis activates human b lymphocytes following interactions with surface igd and class i major histocompatibility complex antigens. | branhamella catarrhalis initiated dna synthesis in human blood or spleen cells enriched for b lymphocytes but did not activate t-lymphocyte-enriched fractions. monoclonal antibodies were used to determine which b-cell surface molecules were of importance for the activation signal. the addition of monoclonal antibodies reactive with igd, hla class i antigens, and b2-microglobulin to b lymphocyte cultures selectively inhibited the b-lymphocyte response to b. catarrhalis. antibody binding to igd an ... | 1988 | 2449982 |
| histamine release from human pulmonary mast cells induced by bacterial antigens. | antigens of four bacteria (staphylococcus aureus, haemophilus influenzae, streptococcus viridans, branhamella catarrhalis) were tested for their ability to release histamine from human pulmonary mast cells recovered by means of bronchoalveolar lavages. for the sake of comparison the action of bacterial antigens on human mesenteric and adenoidal mast cells obtained by enzymatic dispersion of the tissues was studied. bal mast cells released histamine in response to all studied bacterial antigens. ... | 1988 | 2468267 |
| the envelope structure of branhamella catarrhalis as studied by transmission electron microscopy. | the envelope structure of branhamella catarrhalis was studied by electron microscopy and compared with that of other bacteria of the family neisseriaceae, such as moraxella lacunata subsp. liquefaciens and neisseria gonorrhoeae. negative staining of b. catarrhalis showed a mamilliform surface similar to that of moraxella. on thin sections, the cell wall appeared to be made up of a wavy outer membrane tightly linked to a straight peptidoglycan layer. spicule-like structures protruded from the cel ... | 1988 | 2472827 |
| production and characterization of monoclonal antibodies directed against bordetella pertussis lipopolysaccharide. | hybrid cell lines producing monoclonal antibodies against bordetella pertussis lipopolysaccharide (lps) were established. the specificity of the antibodies was ascertained by enzyme-linked immunosorbent assay (elisa) and elisa-inhibition experiments with lps and delipidated polysaccharide fragments (ps-1 and ps-2) prepared from b. pertussis lps. monoclonal antibody 9-1-h5 reacted with b. pertussis lps only, whereas monoclonal antibodies 6-4-h6 and 9-2-a8 reacted with ps-1 and ps-2 as well as b. ... | 1988 | 2893806 |
| restriction fragment mapping of branhamella catarrhalis: a new tool for studying the epidemiology of this middle ear pathogen. | 1988 | 2899124 | |
| monoclonal antibody-based sandwich enzyme-linked immunosorbent assay for detection of bordetella pertussis filamentous hemagglutinin. | hybrid cell lines producing monoclonal antibodies against bordetella pertussis filamentous hemagglutinin (fha) were established. the specificity of the antibodies was ascertained by enzyme-linked immunosorbent assay (elisa), sandwich elisa, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by electroblotting. the monoclonal antibody-based sandwich elisa was developed for detection of b. pertussis fha. the assay had a detection limit of b. pertussis fha in concentrations rang ... | 1988 | 2903174 |
| a nosocomial outbreak of branhamella catarrhalis confirmed by restriction endonuclease analysis. | an outbreak of respiratory illness due to branhamella catarrhalis occurred in the intermediate care unit of a veterans administration hospital and involved patients and staff members. four patients had pneumonia and four had bronchitis. infected patients were placed in a cohort separated from noninfected patients and were treated. pharyngeal culture was used to survey prevalence in staff and all other patients on the unit; three of 18 staff members and two of 19 asymptomatic patients were positi ... | 1988 | 2834470 |
| the in-vitro activity of cp-62,993 against haemophilus influenzae, branhamella catarrhalis, staphylococci and streptococci. | the in-vitro activity of a new macrolide antibiotic cp-62,993 (pfizer ltd) was determined for 420 bacterial isolates, comprising 150 haemophilus influenzae, 48 branhamella catarrhalis, 50 staphylococcus aureus, 50 coagulase negative staphylococci, 50 beta-haemolytic streptococci, 50 streptococcus pneumoniae and 22 oral streptococci. cp-62,993 was compared with erythromycin and penicillin (ampicillin in the case of h. influenzae). the mics of cp-62,993 were found to be lower than those of erythro ... | 1988 | 2837451 |
| in vitro activities of azithromycin (cp 62,993), clarithromycin (a-56268; te-031), erythromycin, roxithromycin, and clindamycin. | the in vitro activity of azithromycin (cp 62,993 or xz-450) against haemophilus influenzae was greater than that of three other macrolides. however, azithromycin was four- to eightfold less active than erythromycin against the gram-positive cocci and against listeria monocytogenes. erythromycin and azithromycin were similar in their activity against legionella pneumophila, neisseria gonorrhoeae, neisseria meningitidis, and branhamella catarrhalis. | 1988 | 2840016 |
| rate of bactericidal activity for branhamella catarrhalis of a new macrolide, cp-62,993, compared with that of amoxicillin-clavulanic acid. | the rate of bactericidal activity of a new macrolide, cp-62,993, was compared with that of the combination of amoxicillin and clavulanic acid (in the proportion of 4 to 1) on strains of branhamella catarrhalis beta-lactamase producers. the antibacterial activity of cp-62,993 was bacterostatic at 0.01 micrograms/ml. after a 6-hour period of bacteriostasis a bactericidal activity (3 log10 cfu/ml) was observed for all concentrations from 0.1 to 10 micrograms/ml after 24 h. the bactericidal rate of ... | 1988 | 2843324 |
| beta-lactamase inhibition by acetylmethylene penicillanic acid compared to that of clavulanate and sulbactam. | the beta-lactamase inhibitory properties of 6-acetylmethylene penicillanic acid (6-ampa) were investigated and compared with those of other beta-lactamase inhibitors. 6-ampa inhibited the tem-1, tem-2, shv-1, pse-1, pse-2, pse-3, pse-4, oxa-2, oxa-3, and staphylococcus aureus beta-lactamases. it also inhibited the chromosomally-mediated beta-lactamases of the richmond-sykes type ia, ic and id type and the type iv klebsiella enzymes. beta-lactamases of branhamella catarrhalis and bacteroides frag ... | 1988 | 2850139 |
| comparison of the microbiology of group a and non-group a streptococcal tonsillitis. | we studied the microbial flora of tonsils removed from 20 children who suffered from recurrent group a beta-hemolytic streptococcal (gabhs) tonsillitis and 20 who had tonsillar hypertrophy following recurrent non-gabhs tonsillitis. similar polymicrobial aerobic and anaerobic flora were recovered from the cores of the tonsils in each group. beta-lactamase-producing bacteria (blpb) were recovered more often in the group with gabhs. this difference was due mostly to the lower incidence of beta-lact ... | 1988 | 3132074 |
| host range of the conjugative 25.2-megadalton tetracycline resistance plasmid from neisseria gonorrhoeae and related species. | high-level tetracycline resistance in strains of neisseria gonorrhoeae, neisseria meningitidis, kingella denitrificans, and eikenella corrodens has recently been described. the resistance in each species is due to the acquisition of 25.2-megadalton conjugative plasmids that carry the tetracycline resistance determinant tetm. we examined the ability of commensal neisseria species to serve as recipients in conjugation for these new plasmids. most of the recipients (n = 21) tested had detectable co ... | 1988 | 3132092 |
| evaluation of a ten-minute chromogenic substrate test for identification of pathogenic neisseria species and branhamella catarrhalis. | a ten-minute chromogenic substrate test was evaluated for its ability to rapidly identify pathogenic neisseria spp. and branhamella catarrhalis. identifications obtained with this system were compared to those obtained using conventional procedures. the test correctly identified 98.9% of 90 neisseria gonorrhoeae, 98.3% of 60 neisseria meningitidis, 96.2% of 26 neisseria lactamica, and 100% of 36 branhamella catarrhalis strains. eight neisseria subflava strains that grew on modified thayer-martin ... | 1988 | 3132371 |
| comparative antimicrobial activity of the new macrolide flurithromycin against respiratory pathogens. | the activity of flurithromycin against haemophilus influenzae, streptococcus pneumoniae, streptococcus pyogenes, branhamella catarrhalis and staphylococcus aureus was determined by the agar dilution method. flurithromycin showed high activity against streptococcus pneumoniae, streptococcus pyogenes and branhamella catarrhalis (mic90 = 0.032-0.25 mg/l). its mic90 value against haemophilus influenzae strains was 4.0 mg/l and 16 mg/l against staphylococcus aureus strains. flurithromycin has promisi ... | 1988 | 3132384 |
| the effects of sinus bacteria on human ciliated nasal epithelium in vitro. | the mechanisms by which bacteria colonize and damage ciliated epithelium are important in understanding the pathophysiology of rhinitis, sinusitis, and otitis. bacteria that have the ability to impair mucociliary clearance would be at an advantage in establishing infection of ciliated surfaces. this study investigates the effect of hemophilus influenzae, streptococcus pneumoniae, branhamella catarrhalis, and staphylococcus epidermidis on the ciliary activity of normal ciliated nasal epithelium i ... | 1988 | 3132682 |
| [branhamella catarrhalis infection]. | 1988 | 3133094 | |
| rapid identification of branhamella catarrhalis with 4-methylumbelliferyl butyrate. | branhamella catarrhalis can be distinguished from neisseria spp. by the presence of butyrate esterase. this enzyme can be rapidly detected when 4-methylumbelliferyl butyrate is used as the substrate. all b. catarrhalis strains tested gave a positive fluorescence reaction within 5 min, while neisseria spp. remained negative, even after 18 h of incubation. | 1988 | 3133392 |
| profiles of amino-acid utilisation and production amongst strains of branhamella catarrhalis. | utilisation and production of amino acids by isolates of branhamella catarrhalis was studied by ion exchange chromatography after cells had been grown in nutrient broth and mueller-hinton broth. the profiles of amino acids used and produced by each strain were compared by a single linkage cluster algorithm. the results of this study reflect the biochemical and physiological heterogeneity amongst strains of b. catarrhalis. | 1988 | 3133481 |
| [branhamella catarrhalis: incidence in pulmonary infections and determination of sensitivity to 5 antibiotics]. | this study reports 45 cases of respiratory tract infection associated with branhamella catarrhalis, diagnosed by bacteriological examination out of 980 sputum samples studied over a 6 months period. these infections were observed mainly in patients with chronic respiratory disease (68.9%). more than half of the isolates were found in pure culture, others were isolated from mixed infections most often with haemophilus influenzae, streptococcus pneumoniae or h. influenzae plus s. pneumoniae. 64.7% ... | 1988 | 3136431 |
| bactericidal activity of bmy-28100 versus amoxicillin/clavulanic acid against branhamella catarrhalis. | 1988 | 3137055 | |
| [respiratory infections caused by branhamella catarrhalis: clinical analysis concerning its pathogenicity]. | 1988 | 3137299 | |
| adherence of branhamella catarrhalis to human pharyngeal cells: its role in the pathogenesis of lower respiratory infection. | 1988 | 3138342 | |
| the epidemiology of respiratory tract pathogens in southern netherlands. | results of sputum cultures and susceptibility tests have been reviewed for the years 1977-1986, with approximately 1,700 positive cultures per year. haemophilus influenzae always occupied the first place, being grown in 65% of positive specimens in 1977 and 37% in 1986. streptococcus pneumoniae occupied the second place, rising from 17 to 27% in the same period, during which branhamella catarrhalis rose from 5 to 26%. based on the frequency of occurrence of individual bacterial species in the sp ... | 1988 | 3139445 |
| laboratory diagnosis of branhamella catarrhalis. | 1988 | 3139719 | |
| comparison of the outer membrane proteins of 50 strains of branhamella catarrhalis. | branhamella catarrhalis colonizes the respiratory tract of humans and commonly causes otitis media in children and respiratory infections in adults with chronic lung disease. in view of the emergence of this organism as an important human pathogen, we used sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) to examine the outer membrane proteins (omps) of 50 strains of b. catarrhalis. omps were isolated from broth culture supernatants. typical of other gram-negative bacteria, ei ... | 1988 | 3139777 |
| branhamella catarrhalis sepsis: a case report and review of the literature. | 1988 | 3139780 | |
| recurrent and penicillin v-resistant otitis media. a treatment study with amoxycillin/clavulanate and cefaclor. | clinical and bacteriological studies were performed in 122 children, aged 1-10 years, with recurrent otitis media or failed therapy with phenoxymethyl penicillin. a specimen for bacteriological culture was taken from the nasopharynx in all patients, and in our material haemophilus influenzae, branhamella catarrhalis and streptococcus pneumoniae were equally distributed, each forming one-third of the total bacterial count. thus, h. influenzae and b. catarrhalis (as well as their betalactamase-pro ... | 1988 | 3140574 |
| branhamella catarrhalis meningitis following otolaryngologic surgery. | a case of pyogenic meningitis caused by branhamella catarrhalis which occurred after pharyngoplasty, adenoidectomy and tympanostomy tube placement is reported. this organism is morphologically similar to neisseria meningitidis but often produces beta lactamase. therefore therapy should be directed by proper microbiologic identification and sensitivity results. | 1988 | 3140851 |
| efficacy of penicillin treatment in purulent maxillary sinusitis. a european multicenter trial. | three hundred and one patients with maxillary sinusitis participated in a double-blind, randomized study at 11 ent-clinics in europe. sinusitis was diagnosed by the presence of at least two signs and symptoms and sinus x-ray showing more than 6 mm swelling of the maxillary mucosa. a microbiological specimen was obtained by intrasinusal aspiration. the patients were randomly assigned to treatment either with bacampillin 800 mg b. i. d. or with amoxicillin 500 mg t. i. d. for ten days. the most fr ... | 1988 | 3141290 |
| spiramycin: in-vitro activity on branhamella catarrhalis. | this in-vitro study of susceptibility to spiramycin of 103 strains of branhamella catarrhalis isolated between 1982 and 1987 was performed by evaluation of their mics. more than 97% of strains remained susceptible with mic less than or equal to 8 mg/l (two strains). one strain presented a mic of 16 mg/l. there were no significant differences of susceptibility to spiramycin between penicillinase-producing and non-producing strains. | 1988 | 3141349 |
| [in vitro activity of 3 fluoroquinolones on branhamella catarrhalis]. | the in vitro antibacterial activities of three fluoroquinolones (pefloxacin, ofloxacin, ciprofloxacin) against 90 clinical isolates of branhamella catarrhalis were assessed by determination of minimum inhibitory concentrations (mics). 73.5% of the strains were producing penicillinase. the mics90 were as follow: ciprofloxacin = 0.2 mg/l. the mic50 and the mic90 were similar. there was no correlation of mics with beta-lactam resistance. lung parenchyma and bronchial mucus diffusion of these three ... | 1988 | 3141885 |
| branhamella catarrhalis bacteremia in children. | 1988 | 3141896 | |
| plasma bactericidal activity after administration of erythromycin estolate and erythromycin ethylsuccinate to healthy volunteers. | in a crossover design study, we compared the plasma bactericidal activities of erythromycin estolate (500 mg) and erythromycin ethylsuccinate (600 mg) after administration of a single oral dose to 12 healthy volunteers. both erythromycin esters displayed very good plasma bactericidal activities against streptococcus pneumoniae. the median bactericidal titers produced in plasma against streptococcus pyogenes and streptococcus pneumoniae were significantly higher with erythromycin estolate than wi ... | 1988 | 3142349 |
| rate of bactericidal activity for branhamella catarrhalis of fleroxacin compared with that of amoxycillin-clavulanic acid. | the rate of bactericidal activity of fleroxacin was compared with that of the combination of amoxycillin and clavulanic acid (in the proportion of 4 to 1) on beta-lactamase producing strains of branhamella catarrhalis. the rate of bactericidal activity of 1 mg/l was as rapid as that of 1 mg/l of amoxycillin-clavulanic acid combination. this rate was not significantly more rapid if the concentrations of fleroxacin were increased to 10 mg/l. in conclusion, the bactericidal activity of fleroxacin i ... | 1988 | 3144548 |
| the antibiotic susceptibilities and beta-lactamase production of clinical isolated branhamella catarrhalis from acute otitis media in children. | branhamella catarrhalis has been misconsidered as a normal resident in human respiratory tract for a long time. however, many authors recently have reported its pathogenecity and isolated it from the otolaryngological region. in our study, this organism can be isolated from the ear and nasal discharge in the child with acute otitis media by the rate of 7.5% and 21.4% respectively. out of this 107 isolated strains, 97 strains (90.7%) were found to be beta-lactamase producing organisms. the mic me ... | 1988 | 3144965 |
| branhamella catarrhalis septicemia in an infant with aids. | branhamella catarrhalis was isolated in blood culture from a 6-month-old infant with aids. the child had a nasopharyngeal infection with respiratory syncytial virus and pneumonitis with pneumocystis carinii. commensal organisms such as b. catarrhalis may be potential pathogens in infants with aids. | 1988 | 3146808 |
| pneumonia due to branhamella catarrhalis. | in 12 of 451 patients diagnosed as having pneumonia in a single hospital over 18 months the causative organism appeared to be branhamella catarrhalis. | 1988 | 3146819 |
| in vitro evaluation of ceftibuten (7432-s, sch 39720), a novel orally administered cephalosporin. | 7432-s (sch 39720) was the most active beta-lactam tested against the enterobacteriaceae, inhibiting 92% of strains at less than or equal to 8.0 micrograms/ml compared to 82%, 65% and 39% of strains inhibited by cefixime, cefuroxime and cefaclor, respectively. 7432-s was also very effective against haemophilus influenzae (mic90, less than or equal to 0.25 microgram/ml), branhamella catarrhalis (mic90, 4.0 micrograms/ml) and neisseria meningitidis (mic90, less than or equal to 0.25 microgram/ml). ... | 1988 | 3147148 |
| branhamella catarrhalis: fatty acid and lipopolysaccharide analysis of an atypical strain from blood culture. | a branhamella catarrhalis-like organism was isolated from blood cultures; it was atypical in showing negative nitrate and nitrite and positive gamma-glutamylaminopeptidase reactions, in agglutinating with neisseria meningitidis antisera, and in forming butyrous colonies. cell-wall fatty-acid and lipopolysaccharide analysis provided evidence that this isolate was an atypical b. catarrhalis. | 1988 | 3147160 |
| selective medium for branhamella catarrhalis with acetazolamide as a specific inhibitor of neisseria spp. | several semiselective media for branhamella catarrhalis have been proposed. these media allow growth of all members of the family neisseriaceae, and further differentiation is necessary. by addition of 10 micrograms of acetazolamide, a carbonic anhydrase inhibitor, per ml and incubation in air, a medium was created which reduced growth of neisseria spp. when saliva samples from 178 healthy schoolchildren were screened for the presence of b. catarrhalis, the carrier rate for this organism was est ... | 1988 | 3147992 |
| characterization of a plasmid isolated from branhamella catarrhalis and detection of plasmid sequences within the genome of a b. catarrhalis strain. | we isolated a 12.2-kb plasmid from two clinical strains of branhamella catarrhalis and evaluated its distribution among other b. catarrhalis strains by colony hybridization experiments using the whole plasmid as a probe. homology was detected with the two plasmid-bearing strains and also with a third b. catarrhalis strain named e7, which is plasmidless. southern transfer analysis of total digested e7 dna using the purified plasmid as a probe revealed a single band of hybridization, different fro ... | 1988 | 3148947 |
| [recent trend of incidence of respiratory pathogenic bacteria and its susceptibility to antimicrobial agents: studies in the year 1984-1986]. | based on a quantitative analysis of sputum cultures, pathogenic bacteria in respiratory ailments isolated in our laboratory during 1984 to 1986 were classified and analyzed. during the study period, the most frequently isolated agent was haemophilus influenzae followed by pseudomonas aeruginosa, branhamella catarrhalis and streptococcus pneumoniae. they together consisted of 70 approximately 74% of all the respiratory pathogenic bacteria isolated in our study. susceptibilities of above pathogens ... | 1988 | 3149325 |
| [clinical experience with ofloxacin in the treatment of chronic respiratory tract disease aggravated by acute infection]. | we studied the clinical usefulness of ofloxacin (oflx) in 13 patients with chronic respiratory tract diseases aggravated by acute infections with identified causative bacteria. 1. overall clinical efficacies were: highly effective 5, effective 6, slightly effective 2, and ineffective none, showing an efficacy rate of 84.6%. 2. in 6 patients with fever of over 37 degrees c, time lengths in days for symptoms to have been alleviated due to oflx treatment were; 1 day: 4 cases, 3 days: 1 case and 5 d ... | 1988 | 3149326 |
| in-vitro activity of amoxycillin/clavulanic acid and five other oral antibiotics against clinical isolates of haemophilus influenzae and branhamella catarrhalis. | the in-vitro activity of amoxycillin/clavulanic acid, amoxycillin, erythromycin, doxycycline, chloramphenicol and cephalexin against 183 clinical isolates of haemophilus influenzae and 61 of branhamella catarrhalis was determined. amoxycillin/clavulanic acid showed the greatest activity against h. influenzae. all isolates of b. catarrhalis were susceptible to amoxycillin/clavulanic acid, chloramphenicol, cephalexin and doxycycline. | 1988 | 3149634 |
| [branhamella catarrhalis and bronchopulmonary infection]. | 1988 | 3149788 | |
| antimicrobial susceptibility testing of haemophilus influenzae, branhamella catarrhalis, and neisseria gonorrhoeae. | 1988 | 3149883 | |
| [laboratory and clinical studies of rokitamycin dry syrup in the field of pediatrics]. | laboratory and clinical studies on rokitamycin (rkm) dry syrup, a new macrolide antibiotic, were carried out in the field of pediatrics. the results are summarized as follows. 1. plasma concentrations and urinary recovery rates after oral administration on fasting of rkm dry syrup at doses of 10 mg/kg and 20 mg/kg to 2 and 1 cases, respectively, were determined. peak plasma levels were obtained in 30 minutes after administration of both dosages with half-lives of 1.5 to 2.2 hours. a clear-cut do ... | 1988 | 3172461 |
| in-vitro and in-vivo activities of t-3262, a new pyridone carboxylic acid. | t-3262[p-toluenesulfonic acid salt of dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid monohydrate] is a new pyridone carboxylic acid with a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria. the activity of t-3262 against most enterobacteriaceae was comparable with that of ciprofloxacin except proteus spp. and providencia rettgeri and exceeded that of ofloxacin and norfloxacin. the activ ... | 1988 | 3182417 |
| comparative in-vitro activity of tigemonam, a new monobactam. | the in-vitro activity against gram-negative aerobic bacterial pathogens of a new oral monobactam, tigemonam, was compared with those of amoxycillin/clavulanic acid, aztreonam, cefaclor, ceftazidime, cefuroxime, ciprofloxacin, co-trimoxazole and gentamicin, by an agar-dilution method. tigemonam inhibited 90% of strains tested of escherichia coli, klebsiella spp., proteus spp., salmonella spp., haemophilus influenzae and branhamella catarrhalis at concentrations of 0.25 mg/l or below. the mic90 fo ... | 1988 | 3182428 |
| antimicrobial activity of ly163892, an orally administered 1-carbacephem. | ly163892 was found to be similar to cefaclor and slightly superior to cephalexin in antimicrobial activity and spectrum. bacteria with mic50 less than or equal to 8.0 mg/l included escherichia coli, klebsiella spp., proteus mirabilis, citrobacter diversus, haemophilus influenzae, branhamella catarrhalis, pathogenic neisseria spp., oxacillin-susceptible staphylococci, and streptococcus spp. strains that produced plasmid-mediated beta-lactamases generally remained susceptible to ly163892. ly163892 ... | 1988 | 3182429 |
| bacteriological findings of acute maxillary sinusitis in young adults. | bacteriological findings in 339 sinus secretions obtained by puncture were investigated in 238 young adult patients with acute maxillary sinusitis. aerobic and anaerobic cultures were performed immediately. a total of 76% of the secretions were positive. the most common pathogens isolated were haemophilus influenzae (50%), streptococcus pneumoniae (19%), streptococcus pyogenes (5%), and branhamella catarrhalis (2%). coagulase-negative staphylococci and staphylococcus aureus were isolated in 8 an ... | 1988 | 3182986 |
| antimicrobial activity, spectrum, and recommendations for disk diffusion susceptibility testing of ceftibuten (7432-s; sch 39720), a new orally administered cephalosporin. | the antimicrobial activity and spectrum of ceftibuten (7432-s; sch 39720) was determined on a wide variety of bacterial species selected for resistance to oral and parenteral beta-lactam antimicrobial agents. ceftibuten was found to be the most active beta-lactam tested against members of the family enterobacteriaceae, inhibiting 81.6% of strains at less than or equal to 8.0 micrograms/ml compared with 75.0 and 54.8% of strains inhibited by cefixime and cefuroxime, respectively. all strains of h ... | 1988 | 3190185 |
| in vitro activity of u-76,252 (cs-807), a new oral cephalosporin. | u-76,252 is the prodrug of u-76,253. mics of u-76,253 were 0.015 to 0.06 microgram/ml for greater than or equal to 90% of the strains of streptococcus spp., haemophilus influenzae, and proteus mirabilis; 0.25 to 1 microgram/ml for branhamella catarrhalis, escherichia coli, klebsiella spp., and citrobacter diversus; 1 to 8 micrograms/ml for staphylococcus spp.; and 2 to greater than 16 micrograms/ml for other members of the family enterobacteriaceae and aeromonas hydrophila; for 72% of the latter ... | 1988 | 3190194 |
| in vitro activities of pd 117,596 and reference antibiotics against 448 clinical bacterial strains. | the in vitro activity of pd 117,596, a new fluoroquinolone antibiotic, was tested against 448 bacterial isolates (15 genera) by agar dilution (inoculum, 10(4) cfu per spot). the activity of pd 117,596 was compared with that of 15 antibiotics against 327 gram-negative strains and with that of 8 other antibiotics against 121 gram-positive strains. pd 117,596 demonstrated the best activity against klebsiella spp., enterobacter spp., acinetobacter spp., serratia marcescens, and branhamella catarrhal ... | 1988 | 3196008 |
| in vitro activity of cefixime, a new oral cephalosporin. | the in vitro activities of cefixime and seven comparative oral antimicrobials were studied. mic90s of cefixime were 0.015-1 micrograms/ml for haemophilus influenzae, branhamella catarrhalis, escherichia coli, klebsiella, citrobacter diversus, proteus, providencia, aeromonas hydrophila and streptococcus. mic90s for other enterobacteriaceae were greater than or equal to 2 micrograms/ml; 44% of those strains were inhibited by less than or equal 1 microgram/ml. staphylococcus, psuedomonas aeruginosa ... | 1988 | 3219746 |
| [clinical evaluation of s 6472 granule preparation (sustained-release cefaclor) in chronic bronchitis]. | s 6472 granule preparation, a sustained-release cefaclor, was orally administered to 20 acutely exacerbated cases of chronic bronchitis at a daily dosage of 750 mg (titer) in 2 divided doses for a duration of 7-15 days and its clinical usefulness was evaluated. clinical efficacies were good in 17 cases and fair in 3 cases, with a rate of efficacy of 85.0%. organisms isolated from 13 patients were totalling 14 strains, i.e., 5 strains of streptococcus pneumoniae, 3 strains of branhamella catarrha ... | 1988 | 3241328 |
| antibacterial activities of cefpodoxime, cefixime, and ceftriaxone. | cefpodoxime, cefixime, and ceftriaxone inhibited branhamella catarrhalis at less than or equal to 1 microgram/ml, beta-hemolytic streptococci at less than or equal to 0.25 microgram/ml, neisseria meningitidis at less than or equal to 0.06 microgram/ml, and haemophilus influenzae (other than beta-lactamase-negative, ampicillin-resistant isolates) at less than or equal to 0.12 microgram/ml. the mics for 50% of isolates of the family enterobacteriaceae other than citrobacter freundii, enterobacter ... | 1988 | 3245701 |
| antimicrobial activity of mdl 19,592: an oral cephalosporin. | mdl 19,592, a semisynthetic oral cephalosporin, has an antimicrobial spectrum principally directed against gram-positive cocci (mic50, 0.25-4 micrograms/ml), branhamella catarrhalis (mic50, 1-2 micrograms/ml), and pathogenic neisseria spp. such as meningococci (mic50, 4 micrograms/ml). enterobacteriaceae, enterococci, pseudomonas spp., corynebacterium jeikeium, and acinetobacter calcoaceticus strains had mdl 19,592 mic50 of greater than or equal to 32 micrograms/ml. although mdl 19,592 generally ... | 1988 | 3246143 |
| [pharmacokinetic, bacteriological and clinical studies of sultamicillin fine granule in pediatric field]. | pharmacokinetic, bacteriological and clinical studies on sultamicillin (sbtpc) fine granule were carried out in the field of pediatrics. the results obtained are summarized as follows. 1. antibacterial activities of sbtpc against clinically isolated strains of haemophilus influenzae, haemophilus parainfluenzae, streptococcus pneumoniae, streptococcus pyogenes, streptococcus agalactiae, staphylococcus aureus, branhamella catarrhalis, and escherichia coli were compared with those of ampicillin (ab ... | 1988 | 3249362 |
| comparative in vitro activities of new 14-, 15-, and 16-membered macrolides. | the in vitro activities of several 14-, 15- and 16-membered macrolides were compared with that of erythromycin. in general, 14-membered macrolides such as erythromycin, clarithromycin, and flurithromycin were more active against streptococci and bordetella pertussis than was the 15-membered macrolide azithromycin, which was more active than 16-membered macrolides such as miocamycin and rokitamycin. clarithromycin was the most active compound against streptococcus pyogenes, pneumococci, listeria ... | 1988 | 3252753 |
| beta-lactamase-producing bacteria in head and neck infection. | we have summarized our experience in recovery of beta-lactamase-producing bacteria (blpb) in head and neck infection (hni). these hni include conjunctivitis, serous and chronic otitis media, cholesteatoma, chronic mastoiditis, chronic sinusitis, adenoiditis, recurrent tonsillitis in children and adults, peritonsillar abscess, and retropharyngeal abscess. beta-lactamase-producing bacteria were found in 262 (51%) of 513 patients with hni; 72% had aerobic blpb and 57% had anaerobic blpb. the infect ... | 1988 | 3258396 |
| bmy-28100, a new oral cephalosporin: antimicrobial activity against nearly 7,000 recent clinical isolates, comparative potency with other oral agents, and activity against beta-lactamase producing isolates. | the antimicrobial activity of bmy-28100 was tested against approximately 7,000 bacterial pathogens in a multicenter, multiphased collaborative investigation. the bmy-28100 spectrum and antimicrobial potency was most similar to that of cefaclor and superior to that of cephalexin among currently available cephalosporins. species that had greater than or equal to 90% of clinical strains inhibited by bmy-28100 (less than or equal to 8.0 micrograms/ml) were: citrobacter diversus, escherichia coli, kl ... | 1988 | 3259489 |
| beta-lactamase production in the upper respiratory tract flora in relation to antibiotic consumption: a study in children attending day nurseries. | the occurrence of beta-lactamase production in haemophilus influenzae, branhamella catarrhalis and moraxella nonliquefaciens was compared in 191 healthy children attending day nurseries in 2 municipalities differing with regard to the prescription rate of beta-lactam antibiotics. a significantly higher frequency of beta-lactamase production was recorded in m. nonliquefaciens isolated in the municipality with the higher prescription rate. a corresponding difference was not recorded for h. influen ... | 1988 | 3261446 |
| staphylococcus epidermidis and staphylococcus aureus in otitis media with effusion. | bacteriologic investigation of middle ear effusion (mee), external ear canal, and the nasopharynx was carried out on 458 patients with otitis media with effusion. staphylococcus epidermidis was the most common bacteria in mee, even after excluding the contaminants from the external ear canal, which had the same value of minimal inhibitory concentration as the paired mee. the bacterial agreement of s epidermidis between mee and the nasopharynx was extremely rare in contrast with haemophilus influ ... | 1988 | 3262358 |
| in-vitro activity and beta-lactamase stability of ly163892. | ly163892 is a new orally absorbed carbacephem. it inhibited streptococcus pyogenes and str. pneumoniae at less than or equal to 1 mg/l, but was less active against group b streptococci and groups c, f, g and bovis streptococci with mics of 1 to 2 mg/l for most but as high as 8 mg/l for some isolates. mic90 of methicillin-susceptible staphylococcus aureus was 8 mg/l, but greater than 128 mg/l for methicillin-resistant staphylococci. ly163892 had activity similar to cefaclor and cephalexin with mi ... | 1988 | 3263352 |
| in vitro antibacterial activity of fk482, a new orally active cephalosporin. | fk482 is a new orally active cephem antibiotic which offers some advantages over the commercially available oral beta-lactam antibiotics. it displayed a broad spectrum of activity in vitro against stock strains of gram-positive and gram-negative aerobes and anaerobes. fk482 was more active in vitro than cefixime (cfix), cefaclor (ccl) or cephalexin (cex) against clinical isolates of gram-positive organisms such as methicillin-sensitive staphylococcus aureus, coagulase-negative staphylococci incl ... | 1988 | 3264828 |
| in vitro evaluations of aminopenicillin/beta-lactamase inhibitor combinations. | sulbactam/ampicillin (unasyn) possesses the antimicrobial activity of each drug plus the synergistic action and qualities of sulbactam used as a beta-lactamase inhibitor. the combination has a spectrum of activity against many enterobacteriaceae, haemophilus species, branhamella catarrhalis, pathogenic neisseria species, acinetobacter anitratus, some pseudomonads, nearly all anaerobes (including bacteroides), staphylococcus species, streptococci, and the enterococci. sulbactam/ampicillin was fou ... | 1988 | 3265377 |
| [antimicrobial activities of sultamicillin against clinical isolates from upper respiratory tract infections]. | sultamicillin (sbtpc) is a mutual prodrug in which ampicillin (abpc) and a potent beta-lactamase inhibitor sulbactam (sbt) are ester-bound in an equimolar ratio. sbtpc is hydrolyzed during absorption after oral administration to provide abpc and sbt for systemic circulation. in the present study, the antimicrobial activities of sbtpc against 50 isolates each of 6 species (staphylococcus aureus, klebsiella pneumoniae subsp. pneumoniae, branhamella catarrhalis, haemophilus influenzae, streptococcu ... | 1988 | 3266508 |
| [antimicrobial activity of sultamicillin against clinical isolates from upper respiratory tract infections ii]. | in an attempt to examine the effect of sulbactam (sbt) on beta-lactamase activity, three hundred clinical isolates from the infected upper respiratory tract were tested for mics and disk sensitivities of ampicillin (abpc) and sultamicillin (sbtpc). beta-lactamase production was tested using the acidometry disk method (beta-check, taito pfizer co.). for strains such as klebsiella spp. which form mucoid type colonies, we used the ss culture medium which, by reducing the influence of huge amounts o ... | 1988 | 3266883 |
| five vs. ten days of therapy for acute otitis media. | in a double blind study 175 patients with acute otitis media were randomized into 2 treatment groups: 10 days of therapy with cefaclor or 5 days of therapy followed by 5 days of placebo. the dosage of cefaclor was 40 mg/kg/day administered orally in equally divided doses at 12-hour intervals. tympanocentesis before treatment yielded specimens that contained streptococcus pneumoniae or haemophilus influenzae or both in 55% of specimens. branhamella catarrhalis was isolated from 21% of specimens. ... | 1988 | 3277153 |
| comparative activity of the 4-quinolones. | minimal inhibitory concentrations (mics) of the 4-quinolones ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin, difloxacin, a-56620, and ci-934 are consistent world-wide, with allowances for differences in acquired resistance. mics of these drugs for enterobacteriaceae correlate with those of nalidixic acid, but resistance to the quinolones is rare if a breakpoint of greater than 2 mg/l is accepted. most intestinal pathogens are sensitive. acinetobacter, pseudomonas aeruginosa, and oth ... | 1988 | 3279501 |
| tigemonam, an oral monobactam. | tigemonam is an orally administered monobactam. at less than or equal to 1 microgram/ml it inhibited the majority of strains of escherichia coli, klebsiella spp., enterobacter aerogenes, citrobacter diversus, proteus spp., providencia spp., aeromonas hydrophila, salmonella spp., shigella spp., serratia marcescens, and yersinia enterocolitica. at less than or equal to 0.25 microgram/ml it inhibited haemophilus spp., neisseria spp., and branhamella catarrhalis. it did not inhibit pseudomonas spp. ... | 1988 | 3279906 |
| comparative in vitro activity of a new fluorinated 4-quinolone, t-3262 (a-60969). | the in vitro activity of a new quinolone, t-3262 [a-60969; dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1-, 4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid monohydrate], was compared with those of ciprofloxacin, ofloxacin, ceftazidime, imipenem, and gentamicin. t-3262 inhibited 90% of isolates of the family enterobacteriaceae at a concentration of less than or equal to 0.25 micrograms/ml. it was two to four times more active than ofloxacin and similarly or slightly less acti ... | 1988 | 3293524 |
| aetiology of acute pharyngitis and clinical response to empirical therapy with erythromycin versus amoxicillin. | one hundred and eighty-nine adults with acute pharyngitis had culture and serological evaluation for group a beta haemolytic streptococci (gabhs), mycoplasma pneumoniae, and branhamella catarrhalis. sixteen patients had evidence for infection with gabhs, none for m. pneumoniae, and one for b. catarrhalis. for those with gabhs, there was no significant difference between empirical treatment by erythromycin or amoxicillin. for those without gabhs, empirical treatment with erythromycin appeared to ... | 1988 | 3294074 |
| [laboratory and clinical studies on cefotetan in respiratory tract infections]. | seventy five patients with respiratory infections, including 40 cases of acute pneumonia, 33 cases of secondary infection after chronic pulmonary diseases and 2 cases of pulmonary abscess, were treated with cefotetan (ctt, yamatetan) by drip infusion in order to evaluate its clinical efficacy. the overall rate of effectiveness was 83.8%. ctt was examined comparatively with other beta-lactam antibiotics for antibacterial activity on clinically isolated strains of 3 major respiratory pathogens inc ... | 1988 | 3043035 |
| [studies on susceptibility of isolated organisms from pediatric infections against various antimicrobial agents]. | twelve oral antimicrobial agents were tested for their antimicrobial activities against causative organisms isolated from pediatric infections. activities of these antimicrobial agents against streptococcus pyogenes were also examined in relation to t-antigen typing of the species. the results of the investigation are summarized as follows. 1. against staphylococcus aureus, rokitamycin (rkm), josamycin, ofloxacin, minocycline exhibited strong antimicrobial activities, and few strains of s. aureu ... | 1988 | 3050184 |
| comparative in-vitro activity of a new oral carbacephem, ly163892. | the in-vitro activity of a new oral carbacephem, ly163892, was compared with cefaclor, cephalexin, cephradine, cefadroxil and selected penicillins against 529 bacterial isolates. ly163892 exhibited greater activity in vitro than all four cephalosporins against haemophilus influenzae, beta-lactamase producing branhamella catarrhalis, escherichia coli, klebsiella spp. and proteus mirabilis. ly163892 had equivalent potency to cefaclor against non-beta-lactamase producing b. catarrhalis, streptococc ... | 1988 | 3060458 |
| cefuroxime axetil. | cefuroxime axetil is a orally active prodrug formulation of cefuroxime, which upon absorption undergoes immediate deesterification to free cefuroxime. cefuroxime axetil offers an in vitro antibacterial spectrum against many gram-positive and some gram-negative organisms. its beta-lactamase stability makes it useful in treating a variety of infections caused by beta-lactamase-producing strains of haemophilus influenzae, branhamella catarrhalis, and staphylococcus aureus. cefuroxime axetil has goo ... | 1988 | 3063476 |
| [clinical trials of flomoxef in patients with chronic respiratory tract infections]. | flomoxef (fmox, 6315-s), a newly developed oxacephem drug, was administered to 6 patients with chronic respiratory tract infections. bacteriological examination of these infections using quantitative sputum cultures revealed that 2 patients had haemophilus influenzae, 2 had branhamella catarrhalis and 2 had mixed pathogens (one was with h. influenzae + b. catarrhalis and the other with streptococcus pneumoniae + b. catarrhalis). the administration of the drug was done by drip infusion, twice dai ... | 1988 | 3063850 |
| management of otitis media in infants and children: current role of old and new antimicrobial agents. | otitis media, the diagnosis most frequently made by the pediatrician, is most effectively treated with antimicrobial therapy. amoxicillin (or ampicillin) has been the standard for infants and children with acute otitis media because it is safe and effective for most of the causative bacterial pathogens. amoxicillin has also been shown to be effective for treatment of some children with otitis media with effusion ("secretory" otitis media) and is the recommended prophylactic antimicrobial agent f ... | 1988 | 3064037 |
| sinusitis in children. | upper respiratory tract infection and allergic inflammation are recognized as the important risk factors for acute sinusitis, with upper respiratory tract infection being most common. in children with acute or chronic sinusitis, the respiratory symptoms of nasal discharge, nasal congestion and cough are usually prominent. radiography has traditionally been used to determine the presence or absence of sinus disease. the radiographic findings most diagnostic of bacterial sinusitis are diffuse opac ... | 1988 | 3064040 |