Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| hla-linked control of susceptibility to tuberculoid leprosy and association with hla-dr types. | in an attempt to confirm an hla-linked effect on the course of mycobacterium leprae infection observed in families from surinam (south america), we conducted a similar family study in an endemic area in india. we observed a significant (p less than .05) excess of identical hla-glo haplotypes only from healthy parents among siblings affected with tuberculoid leprosy. compared with healthy controls, unrelated patients with tuberculoid leprosy (n = 15) showed a significant heterogeneity at the hla- ... | 1980 | 7008255 |
| foot pad enlargement as a measure of induced immunity to mycobacterium leprae. | foot pad enlargement (fpe) has been used as a measure of induced immunity to m. leprae, fpe peaked at 2-3 days, but it sometimes persisted for 4 weeks or more. both as the inducing and eliciting antigen, heat-killed m. leprae were effective, and the optimum dose was about 1 x 10(7) bacilli. higher doses were associated with flattening of the dose-response curve. disrupted bacilli were not effective in immunizing mice, but they elicited fpe responses in mice immunized with intact bacilli. cord fa ... | 1980 | 7009447 |
| evidence for species-specific lipid antigens in mycobacterium leprae. | a partially purified lipid fraction from mycobacterium leprae yielded distinct lines of precipitation with antisera from two lepromatus patients and from an infected armadillo. there was no reaction to the sera from patients with tuberculosis or a m. avium infection or to the serum from a normal armadillo. the activity in the lipid fraction was unaffected by mild alkali, and upon hydrolysis the fraction yielded 6-deoxyhexoses. this information suggests that the lipid antigens of m. leprae may be ... | 1980 | 7009448 |
| an improved embedding method for electron microscopy of lepromata. | spurr's resin mixture has been found to be the embedding material most suitable for electron microscopic studies of lepromata at present. like methacrylate, it can penetrate well into foamy structures and the leprosy bacilli within foamy structures. on the other hand, like epon 812, it is stable against the electron beam and can preserve ultrafine structures. additionally, we have found that the use of dimethylformamide or dimethylsulfoxide instead of propylene oxide as substituter improves the ... | 1980 | 7009449 |
| thoughts on the immunology of leprosy. | 1980 | 7009450 | |
| identification problems of strain 0122. | 1980 | 7009452 | |
| genetics and leprosy. | 1980 | 7009982 | |
| multivariate analysis of the activity of rifamycins against rapidly growing mycobacteria, to define an in vitro screening model for their activity against mycobacterium leprae. | in an attempt to select a group of rapidly growing mycobacteria which could serve as a model for the in vitro screening of rifamycin derivatives for their activity against mycobacterium leprae, the mic values of 237 strains of rapidly growing mycobacteria were determined for 4 reference rifamycins with known activity against m. leprae and 19 rifamycins with unknown activity against m. leprae. study of the results by a multivariate statistical technique, the principal components analysis, defined ... | 1980 | 7011330 |
| drug resistance in leprosy. | 1980 | 7026426 | |
| leprosy without mycobacterium leprae. | 1980 | 7021515 | |
| superoxide dismutase, peroxidatic activity and catalase in mycobacterium leprae purified from armadillo liver. | superoxide dismutase has been identified and peroxidatic activity demonstrated in mycobacterium leprae. the superoxide dismutase, shown indirectly to be a manganese-containing enzyme, was present at low activity in the cell-free extract. peroxidatic activity was detected in a haemoprotein on polyacrylamide gels, but quantitative assay was not possible. catalase, although present in a cell-free extract, appeared to be a host-derived enzyme, thus emphasizing the importance of establishing the auth ... | 1980 | 7021767 |
| the genetic hypothesis for susceptibility to lepromatous leprosy. | evidence for genetic influence of the host response to infection with mycobacterium leprae is reviewed. a complex segregation analysis is performed on data for 91 families from mactan, philippines, in each of which at least one offspring developed lepromatous leprosy. the data are not found to be inconsistent with an autosomal recessive hypothesis for susceptibility to lepromatous leprosy. heritability estimates in the range of 80% were calculated for sib-sib pairs under the multifactorial hypot ... | 1979 | 511131 |
| leprosy's footprints in bone-marrow histiocytes. | 1979 | 85259 | |
| leprosy's footprints in bone marrow. | 1979 | 88011 | |
| identification of a mycobacterium leprae specific protein antigen(s) and its possible application for the serodiagnosis of leprosy. | acetone-killed mycobacterium leprae separated from infected armadillo liver tissue without the use of proteases were treated with 0.2 m lithium acetate, 20 mm edta, ph 8.8 solution, and the concentrated antigen extract was analyzed by ouchterlony immunodiffusion. the antigen extract gave a single immunoprecipitate when reacted with pooled lepromatous leprosy (ll) patients sera made highly specific for m. leprae by adsorption. apparently identical precipitates were produced by reacting the antige ... | 1979 | 90666 |
| pyridine extractability of acid-fastness from mycobacterium leprae. | various mycobacteria were tested for their ability to retain acid-fastness after treatment with pyridine: a) mycobacterium leprae separated from organs of 20 experimentally infected armadillos (which were sacrificed); b) m. leprae separated from a biopsy of a lepromatous patient; c) direct smears of lepromatous tissues from armadillos; d) eighteen cultivable mycobacteria obtained from the american type culture collection (atcc); e) cultivatable mycobacteria separated from the lymph nodes of a wi ... | 1979 | 90667 |
| pyridine extraction of m. leprae. | 1979 | 90668 | |
| the harada's staining method for leprosy bacilli. | 1979 | 91361 | |
| importance of the neural predilection of mycobacterium leprae in leprosy. | it is suggested that continuous leakage of bacilli into the circulation from a primary focus of intraneural infection may simultaneously initiate bacillary dissemination and the suppression of cell-mediated immunity. both these features are essential for the development of lepromatous leprosy. nerve involvement in leprosy, previously thought of as a diagnostic feature of the disease and as a complication of therapy, may represent an essential phase in the cycle of infection and reinfection by my ... | 1979 | 91779 |
| therapeutic effect of intravenously administered yeast glucan, in mice locally infected by mycobacterium leprae. | 1979 | 94971 | |
| reconstructive surgery for hansen's disease (leprosy). | 1979 | 115386 | |
| metabolic inhibitors of host-tissue origin in mycobacterium leprae. | it is not clear why host-derived bacteria are metabolically inert, compared to organisms grown in vitro. o-diphenoloxidase is the only metabolic property proven to be present in mycobacterium leprae separated from infected human as well as animal (mouse and armadillo) tissues. however, highly concentrated suspensions of m. leprae obtained from the organs of experimentally infected armadillos showed little or extremely low o-diphenoloxidase, while the organisms bound 14c-labeled dopa. when these ... | 1979 | 117257 |
| the review of chemotherapeutric trials on leprosy and its present states in korea. | 1979 | 118593 | |
| cholesterol dynamics in macrophages implication for the bacteriology and pathology of leprosy. | m. leprae in the host multiplies abundantly in macrophages rich in cholesterol. host-grown leprosy bacilli have an extremely high cholesterol content and in this respect they occupy a unique place among procariotic cells. m. leprae takes up cholesterol from the environment and it is not clear whether it can synthesize cholesterol and if so from which precursors. mycobacteria can be grown from leprous tissues in primary cultures only in the presence of cholesterol. these strains quickly adapt to ... | 1979 | 121019 |
| mycobacterium leprae: atypical and unclassified. | once m. leprae is grown on artificial media in the test tube, it might prove to have a great variety of characteristics quite different to those expected from our knowledge of m. leprae isolated from the susceptible host. the cultures might be slow or fast growing, pigmented or colorless, pathogenic for the armadillo, or not; they might produce limited disease in the foot pad of mice, or the contrary. the in vitro m. leprae culture might or might not provoke a lepromine reaction; the culture mig ... | 1979 | 121020 |
| epidemiology of leprosy. | 1979 | 121021 | |
| [mycobacterial antigens of the hansen group studied with immuno-electrophoresis]. | 1979 | 121830 | |
| [lepromin scars in leprosy patients and persons without manifestations of the disease tested with human antigen and various concentrations of armadillo antigens (double-blind study)]. | 1979 | 121832 | |
| [early reaction (fernandez) in children and adolescents without contact or manifestations of leprosy, tested with human lepromin and different concentrations of armadillo antigens in 3 double-blind studies]. | 1979 | 121833 | |
| [in vitro culture of mycobacterium leprae]. | 1979 | 121842 | |
| [dapsone resistance in west africa]. | 1979 | 121854 | |
| cross-reactions between mycobacteria. ii. crossed immunoelectrophoretic analysis of soluble antigens of bcg and comparison with other mycobacteria. | cross-reactions between mycobacterium bovis bcg and various other mycobacteria, nocardia asteroides, corynebacterium pyogenes and listeria monocytogenes were studied by incorporating antibodies against these bacteria in the intermediate gel of a crossed immunoelectrophoretic system with bcg antigen and anti-bcg antibodies. in the bcg reference system forty-four distinct antigenic components were recorded, of which thiryt-three cross-reacted with mycobacterium tuberculosis, twenty-five with m. av ... | 1979 | 106465 |
| neonatally thymectomized lewis rats infected with mycobacterium leprae. 2. histopathologic and electron microscopic observations. | we report the histologic and electron microscopic findings following intravenous inoculation of m. leprae into neonatally thymectomized lewis rats, which were killed one to two years later. all organs appeared normal grossly. histologic changes were confined to the footpads, snout, ears, tail, and testes, all of which were involved in every rat. the tissues were edematous and infiltrated by varying numbers of foamy macrophages. in the footpads muscle fibers were vacuolated, and small nerves show ... | 1979 | 122625 |
| in vitro activation of neutrophils by suspensions of mycobacterium leprae. | activation, defined as an increase in the proportion of cells that reduce nitroblue-tetrazolium in vitro, is present in neutrophils from patients with reactional lepromatous leprosy but not in neutrophils from patients with non-reactional lepromatous leprosy. neutrophils from patients with all forms of leprosy are equally well activated by endotoxin in vitro. we have now shown that in vitro activation induced by mycobacterium leprae suspensions is of comparable magnitude in neutrophils from pati ... | 1979 | 122626 |
| defective blood mononuclear phagocyte function in patients with leprosy. | patients with lepromatous leprosy possess a defective lymphocyte function in vivo and in vitro that is less evident in the tuberculoid form. data concerning their macrophage ability to digest mycobacterium leprae are controversial. the purpose of this study was to determine whether monocytes from patients with either tuberculoid or lepromatous leprosy were altered in their enzyme systems, that is myeloperoxidase-dependent and myeloperoxidase-independent systems. the ability of adherent blood mon ... | 1979 | 122627 |
| electron microscopic observations of intracytoplasmic membrane systems and cell division in mycobacterium lepraemurium. | the fine structures and the interconnections between the intracytoplasmic membrane systems and cell division of murine leprosy bacilli in liver tissue from mice infected intraperitoneally with mycobacterium lepraemurium, hawaiian strain, were studied in ultrathin serial sections at the electron microscopic level. intracellular membranous organelles (mesosomes) were seen as vesicular, tubular and/or lamellar structures. the formation of mesosomes appeared to be initiated by invagination and/or fo ... | 1979 | 122629 |
| concanavalin a induced suppressor activity in human leprosy. | peripheral blood lymphocytes from nine normal subjects and 40 patients with leprosy were pretreated in vitro with concanavalin a (con a). cells from normal subjects pretreated for 24 hours showed consistent and effective generation of suppressive activity which inhibited mitogen induced transformation of autologous lymphocytes. prolongation of con a pretreatment to 40 hours resulted in maximal suppressive activity. tuberculoid leprosy patients had lymphocytes in their blood which on 24 hour pret ... | 1979 | 161322 |
| superoxide, superoxide dismutase, lipoperoxidation, and m. leprae. | 1979 | 222696 | |
| diabetic status in leprosy. | the diabetic status of the local jhansi patients (120 cases) was established before and after antileprosy treatment. control studies were performed in normal healthy subjects (50 persons) without family history of diabetes mellitus. random normals showed an incidence of diabetes only 2%, while leprosy patients (94 males and 26 females) had incidence of diabetic status of 14.2%. the highest incidence (19.3%) of diabetes was in lepromatous leprosy and lowest incidence (6.4%) in tuberculoid leprosy ... | 1979 | 261975 |
| recommended safety requirements for the preparation of lepromin: a who memorandum. | the need for standardizing the preparation of lepromin and establishing safety requirements for it was recognized by the scientific working group on the immunology of leprosy (immlep) and its steering committee in 1978. it has now recommended the preparation of standard integral (mitsuda-type) lepromin and, in collaboration with the who biologicals unit, has drafted requirements for its preparation and testing. these direct that the source material should be mycobacterium leprae from biopsy spec ... | 1979 | 317019 |
| discharge of mycobacterium leprae from the mouth in lepromatous leprosy patients. | 1979 | 370480 | |
| [study of m. leprae ultrastructure in human leproma]. | 1979 | 371265 | |
| comparative ultrastructure of mycobacterium leprae and mycobacterium lepraemurium cell envelopes. | the structural properties of the cell envelopes of mycobacterium leprae and mycobacterium lepraemurium were investigated by freeze-fracture, freeze-etching, and negative-staining techniques. freeze-fracture split the cell wall and exposed the internal features of the peptidoglycolipid mycosidic filamentous network. the cell membrane was also split into two asymmetric faces. the external fracture face was characterized by linear arrays of intramembranous particles, whereas the protoplasmic fractu ... | 1979 | 374395 |
| immunological changes observed in indeterminate and lepromatous leprosy patients and mitsuda-negative contacts after the inoculation of a mixture of mycobacterium leprae and bcg. | this investigation was carried out to study the possibility of eliciting favourable immunological changes in small groups of mitsuda-negative patients with indeterminate leprosy, lepromatous patients who were bacteriologically negative after prolonged treatment with sulphones, and in mitsuda-negative contacts by means of stimulation with a mixture of autoclaved tissues from mycobacterium leprae-infected armadillos and living bcg. a radical change was observed in the specific immunological activi ... | 1979 | 383331 |
| delayed hypersensitivity responses in mice and guinea pigs to mycobacterium leprae, mycobacterium vaccae, and mycobacterium nonchromogenicum cytoplasmic proteins. | antigenic relationships between mycobacterium vaccae, m. nonchromogenicum, and m. leprae were examined in mice and guinea pigs injected with m. vaccae or m. nonchromogenicum suspensions. the growth of both organisms in outbred icr and four inbred mouse strains was followed up to 30 days. m. nonchromogenicum persisted in the livers and spleens of the inbred mice substantially better than did the m. vaccae population in the same mouse strains. a translucent colony variant of m. vaccae isolated fro ... | 1979 | 383613 |
| in vitro lymphocyte stimulation in leprosy; simultaneous stimulation with mycobacterium leprae antigens and phytohaemagglutinin. | 1979 | 385182 | |
| experimental leprosy with nude mice. | 1979 | 389919 | |
| behaviour of macrophages to mycobacterium leprae. a tissue culture study. | macrophage culture was performed on 45 healthy adults who were initially categorised on the basis of their lepromin reactivity using dharmendra antigen. there were 25 individuals in the lepromin positive group and 20 in the lepromin negative group. the cultures were challenged with m. leprae and the macrophages studied at varying time intervals of culture. no difference was evident in the behaviour of cultured macrophages to m. leprae in both the groups. the lepra bacilli were phagocytosed by th ... | 1979 | 390240 |
| a study of scrotal biopsy in subsided cases of lepromatous leprosy. | scrotal biopsies were obtained from 38 cases of lepromatous leprosy who were clinically subsided and had negative skin smears. twenty six (68.4%) of these cases revealed bacilli in the dartos muscle. none except one showed a specific lesion in the dartos. bacilli obtained from 2 out of 7 cases multiplied in the mouse foot-pad. bacilli were found to be persisting in the dartos muscle despite prolonged treatment before as well as after clinical subsidence of the disease. the persisting bacilli in ... | 1979 | 390241 |
| [comparative study of the variable averages and bacilloscopic and morphologic indexes in virchowian hansen patients treated with rifampicin and diaminediphenylsulfone]. | 1979 | 390679 | |
| the significance of the presence of m. leprae in tuberculoid cases. | 1979 | 392190 | |
| systemic involvement in tuberculoid leprosy--pathogenesis of leprosy. | occurrence of leprous pathology/bacilli in the internal organs in cases of polar tuberculoid leprosy, support the systemic nature and haematagenous transmission and spread of the disease process. pathogenesis of leprosy has been postulated. | 1979 | 392191 |
| dapsone-resistant leprosy in ethiopia. | 1979 | 392212 | |
| palatal involvement in lepromatous leprosy. | 1979 | 392213 | |
| cultivation requirements for treponema pallidum, mycobacterium leprae and other microbial and mammalian microaerophilic cells. | atmospheric and biological evolution progressed simultaneously and today certain cell types flourish only at oxygen tensions which were ambient 600 million years ago, i.e., at 5 to 10 mm hg. in man, a continuous oxygen flow at these pressures is supplied in the skin where treponema pallidum, mycobacterium leprae and members of the genus rickettsia grow best. in vitro studies support the microaerophilic status of these organisms and of certain other microbial and mammalian cells. vigorous growth ... | 1979 | 392268 |
| [experimental transmission of m. leprae in mice treated with anti-lymphocyte serum (author's transl)]. | 1979 | 395145 | |
| [expermental transmission of m. leprae into the testes of mice born from 60co-irradiated pregnant mice]. | 1979 | 395146 | |
| advances in dermatology: 1--leprosy immunology. | 1979 | 395793 | |
| antibody activity against mycobacterium leprae antigen 7 in leprosy: studies on variation in antibody content throughout the spectrum and on the effect of dds treatment and relapse in bt leprosy. | 1979 | 396427 | |
| the saga of the skin smear. | 1979 | 397385 | |
| selection of sites for slit-skin smears. | 1979 | 397387 | |
| the fingers as sites of leprosy bacilli in pre-relapse patients. | 1979 | 397388 | |
| the development of an active vaccine against leprosy. | 1979 | 397704 | |
| lepromatous leprosy as a model of schwann cell pathology and lysosomal activity. | a brief illustrated account is presented of the light microscopic pathology, histochemistry of lysosomal enzymes, and fine structural changes in the nerves of patients with untreated or treated lepromatous leprosy. predominant bacillation of the schwann cells of unmyelinated fibres, degeneration of their axons, prominence of phagolysosomes, and disappearance of these cells with endoneurial collagenosis were observed on electronmicroscopic examination of the index branch of the radial cutaneous n ... | 1979 | 399208 |
| the relevance to protection of three forms of delayed skin-test response evoked by m. leprae and other mycobacteria in mice. correlation with the classical work in the guinea-pig. | the controversy surrounding the protective role of 'delayed hypersensitivity' in tuberculous guinea-pigs has never been resolved. this controversy has arisen because the term 'delayed hypersensitivity' is used indiscriminately to describe both a type of necrotic skin-test reactivity which does not appear until 4-6 weeks after infection, and also non-necrotic reactions which can be elicited within a few days. responses closely analogous to both have been characterized in mice immunized with mycob ... | 1979 | 399333 |
| phagosome/lysosome fusion: a possible prerequisite for the enhancement of antibody responses in vitro by bcg, mycobacterium leprae and corynebacterium parvum. | primary in vitro antibody responses to srbc were suppressed in cultures prepared from the spleens of cba mice injected i.v. 20 days previously with 10(8) liver bcg. in contrast, cultures prepared from mice injected with dead bcg showed enhanced responses. in vitro spleen cell responses of the mice had returned to normal levels 4--6 weeks after their injection, but if dead bcg, m. leprae or c. parvum was added to the cultures, responses were enhanced. the enhancing effect of the added bacteria co ... | 1979 | 399339 |
| do leprosy patients in papua new guinea take their dapsone? | 1979 | 399578 | |
| the brown animal sanatory institution. | 1979 | 372441 | |
| the effect of freezing and storage in liquid nitrogen on the viability and growth of mycobacterium leprae. | the effects of rapid and slow rates of freezing in liquid nitrogen, storage in liquid nitrogen for 12 months, and the rate of subsequent thawing on the viability and growth of m. leprae in the mouse footpad were studied. some loss of viability of m. leprae was detected, and this was found to be associated with the freezing process, rather than with storage or thawing. slow freezing was less deleterious than quick freezing, with a loss of viability of 90% compared with 98%. the growth pattern of ... | 1979 | 372533 |
| antigenic analysis of mycobacterium leprae. | about twenty distinct antigenic components have been demonstrated in mycobacterium leprae (m. leprae) by crossed immunoelectrophoresis against a rabbit antiserum produced by immunization with concentrated m. leprae antigen. this system allows a more detailed analysis of the antigenic relationship between m. leprae and other mycobacteria and a better characterization of the antigenic content of various m leprae preparations than with previously available anstisera of the antigenic content of vari ... | 1979 | 373076 |
| respiratory system involvement in leprosy. | 1979 | 376452 | |
| fluorescence microscopy for detection of m. leprae in tissue sections. | the fluorescence method was compared with the fite-faraco method for detecting acid-fast microorganisms in paraffin sections of cases of leprosy. biopsies were obtained from 50 cases of leprosy covering all varieties and at varying stages of treatment. the fluorescence method was better than the fite-faraco method; 22 biopsies showing acid-fast organisms in fluorescence microscopy and 20 in the fite-faraco method. its superiority was evidenced in two cases in which the organisms were very scanty ... | 1979 | 376453 |
| therapeutic effects of adding rimactane (rifampicin) 450 milligrams daily or 1200 milligrams once monthly in a single dose to dapsone 50 milligrams daily in patients with lepromatous leprosy. | 1979 | 376454 | |
| use of a common indian herb "mandukaparni" in the treatment of leprosy. a preliminary report. | 1979 | 376942 | |
| the role of macrophages in leprosy as studied by protein synthesis of macrophages from resistant and susceptible hosts--a mouse and human study. | 3h-leucine uptake by macrophages from swiss white and c57bl mice before and after m. leprae infection was studied. a depression in 3h-leucine uptake after infection was observed only in swiss white mice. 3h-leucine uptake was also studied in blood derived macrophages from normals, and ll and tt patients. a depression was obtained in 3h-leucine uptake after m. leprae infection in macrophages from ll patients. | 1979 | 376943 |
| histopathologic study of clinically normal appearing skin in lepromatous leprosy. | skin biopsies from clinically normal skin of the scalp, axillary and groin regions in 20 lepromatous leprosy patients revealed significant histopathological findings in upto 25 percent of the patients. the positive findings could, perhaps, be enhanced by studying larger skin materials from these body areas. indeed, no skin area appears to be immune from invasion by myco. leprae. | 1979 | 376944 |
| the significance of changes in the nasal mucosa in indeterminate, tuberculoid and borderline leprosy. | a study of nasal biopsies from 137 leprosy patients classified on the basis of clinical, microbiological and skin biopsy as indeterminate, tuberculoid, borderline-tuberculoid and borderline-leproma was undertaken. changes suggestive of leprosy viz., nerve and smooth muscle inflammation with a few acid fast bacilli in a proportion of the biopsies were seen in all groups of patients examined. this suggests, that even in indeterminate and tuberculoid leprosy the disease becomes generalised by the t ... | 1979 | 376945 |
| induction of cell-mediated immunity to mycobacterium leprae in guinea pigs. | guinea pigs immunized with intact or disrupted armadillo-grown human mycobacterium leprae administered in aqueous or oil vehicles were tested with various dilutions of m. leprae suspended in saline, water-soluble m. leprae extract, purified protein derivative, and a water-soluble extract of normal armadillo tissue. the results demonstrated the following. (i) under no conditions was any skin test reactivity found to normal armadillo tissue extract. (ii) positive sensitization to both m. leprae an ... | 1979 | 378838 |
| lymphocyte transformation test in healthy contacts of patients with leprosy. i. influence of exposure to leprosy within a household. | fifty-three household contacts of lepromatous patients, 37 household contacts of tuberculoid patients, and 91 control persons were examined with the lymphocyte transformation test (ltt) for their responses to whole and sonicated antigen preparations from m. leprae, to bcg, m. avium, m. gordonae, and phytohemagglutinin (pha). the study was carried out in the gurage area of ethiopia in 15 households with a leprosy patient and 15 matched control households. household contacts of lepromatous patient ... | 1979 | 378871 |
| lymphocyte transformation test in healthy contacts of patients with leprosy. ii. influence of consanguinity with the patient, sex, and age. | the study was carried out in the gurage area of ethiopia, where 53 household contacts of lepromatous patients, 37 household contacts of tuberculoid patients, and 91 control persons were examined with the lymphocyte transformation test (ltt) for their responses to whole and sonicated antigen preparation from m. leprae to bcg, m. avium, m. gordonae and phytohemagglutinin. the potential influence of host factors, namely the state of consanguinity with the leprosy patient, sex and age on the ltt res ... | 1979 | 378872 |
| committee 2: workshop on the microbiology of leprosy. | 1979 | 378875 | |
| committee 4: workshop on experimental chemotherapy of leprosy. | 1979 | 378876 | |
| research in leprosy. a report of a committee set up by the medical research council to study future prospects. | recommendations for future research in leprosy include (i) cultivation of m. leprae in vitro; (ii) genetic control of susceptibility, including twin studies and hla typing; (iii) precise antigenic analysis of m. leprae; (iv) mechanisms involved in the macrophage response to mycobacterial infections; (v) more use of experimental models such as normal mice infected with m. lepraemurium; (vi) reassessment of the protection afforded by bcg; (vii) assessment of protection afforded by killed (armadill ... | 1979 | 380853 |
| in vitro studies on biopsies from leprosy cases. | 1979 | 381188 | |
| comparative biochemistry and drug design for infectious disease. | in the past two decades, biochemistry and molecular biology have demonstrated the existence of potentially exploitable biochemical differences between etiologic agents of disease and their hosts. known differences between organism and host with respect to metabolism and polymer structure point to the detailed characterization of key proteins as the focus for the development of potential inhibitors. in the last decade, the methodology of the isolation, characterization, and inactivation of protei ... | 1979 | 382357 |
| interaction of mycobacterium leprae and mycobacteriophage d29. | this study of the interaction between mycobacterium leprae and the mycobacteriophage d29 showed that the viruses caused a patchy damage of cell wall structure and the accumulation in the host of internal crystalline structures. whether the observed ultrastructural alterations were caused by the replication of d29 was not clear. mitomycin c also caused the accumulation of crystalline structures in m. leprae. | 1978 | 382947 |
| leprosy-like disease of wild armadillos in french acadiana, louisiana. | 1978 | 376833 | |
| the role of macrophages in the lymphoproliferative response to mycobacterium leprae in vitro. | peripheral blood lymphocytes from patients suffering from lepromatous leprosy do not normally react in vitro to stimulation by mycobacterium leprae antigens. in contrast, we found that t cells from non-responding patients in combination with macrophages from responding patients or healthy contacts did respond well to m. leprae. conversely, t cells from responding patients or healthy contacts in combinations with macrophages from non-responding patients failed to respond. it seems, therefore, tha ... | 1978 | 373933 |
| cutaneous leishmaniasis and leprosy. | eight patients who had concomitant leprosy and leishmaniasis are described. two patients with lepromatous leprosy had high resistance leishmaniasis, implying that the immune deficiency in lepromatous leprosy is specific to mycobacterium leprae. | 1978 | 653788 |
| reversal reaction in patients with lepromatous leprosy after transplantation of human fetal thymic grafts. | an attempt has been made to reconstitute impaired cell-mediated immunity in 1 patient with indeterminate, 4 patients with borderline and 2 patients with polar lepromatous leprosy by grafting three thymus glands obtained from human fetuses of 14--19 weeks gestation. most of these patients had severe ulcerative erythema nodosum leprosum (enl) and were intolerant to dapsone. after thymus transplantation these patients were followed for 1 1/2 years. during this period, all conventional chemotherapy ... | 1978 | 664571 |
| combinations of rifampicin and isoprodian in the treatment of mycobacterium leprae infections in mice. | 1978 | 701209 | |
| reversal reactions in lepromatous leprosy following transfer factor therapy. | five patients with active leprosy, four with polar lepromatous (ll) and one with borderline lepromatous (bl) disease, were each treated with transfer factor (tf) from approximately 7.4 x 10(9) lymphocytes given in 36 divided doses over a 12-week period. the tf was prepared from blood donated by normal, healthy, lepromin skin test-positive individuals. during treatment all four of the ll patients, but not the bl patient, developed clinical reversal reactions. histopathologically, skin biopsies in ... | 1978 | 717642 |
| gut-associated iga deficiency in lepromatous leprosy. | sera, intestinal secretions and intestinal biopsies were collected from twelve biopsy-proved lepromatous leprosy patients with the help of a capsule invented by roy choudhury. sera from another twenty-five proved lepromatous cases were also included. sera and intestinal aspirates from twenty-five normal subjects and twenty patients with intestinal tuberculosis were also taken as controls. acid-fast organisms, morphologically resembling mycobacterium leprae, were detected in the intestinal aspira ... | 1978 | 725534 |
| activity of derivatives and analogs of dapsone against mycobacterium leprae. | of 25 dapsone derivatives and analogs screened for activity against mycobacterium leprae in the mouse footpad system, only 7 were active. all seven were metabolized to or contaminated with dapsone. | 1978 | 727767 |
| immunological relatedness of ribosomes from mycobacteria, nocardiae and corynebacteria, and microorganisms in leprosy lesions. | serological relatedness of ribosomes from microorganisms of the mycobacterium, nocardia, and corynebacterium genera has been analyzed by the microplate immunodiffusion technique. mycobacterium and nocardia proved homogeneous and closely related taxa, whereas corynebacterium was found to be a heterogeneous phylum connected by remote links to the others. the taxonomic position of "diphtheroid microorganisms" (non-acid-fast, gram-positive bacteria morphologically similar to corynebactria), which we ... | 1978 | 730371 |
| development of hodgkin's disease in a patient with leprosy. | we present a patient with leprosy who developed hodgkin's disease of the nodular sclerosing type. there are two previous reports describing the combination of leprosy and hodgkin's disease in a single patient [3, 9]. hodgkin's disease was diagnosed 14 months after the complete disappearance of mycobacterium leprae from the skin lesions, under treatment with dds (diamino-diphenyl-sulfone). hodgkin's disease was treated by irradiation and chemotherapy. obstructive jaundice developed which resolved ... | 1978 | 745813 |
| development of an anti-leprosy vaccine -- progress in dharmendra. | 1978 | 374867 | |
| towards development of a vaccine against leprosy. introduction. | 1978 | 374868 | |
| five cultivable mycobacterial strains giving blast transformation and leukocyte migration inhibition of leukocytes analogous to mycobacterium leprae. | 1978 | 374869 | |
| delayed hypersensitivity skin reactions to homologous and heterologous antigens in guinea-pigs immunized with m. leprae and four selected cultivable mycobacterial strains. | 1978 | 374870 |