Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| borderline tuberculoid leprosy following bcg vaccination. a case report. | borderline tuberculoid leprosy was diagnosed clinically and histologically in a four year-old boy about 6 months after intradermal vaccination with bcg. his mother reported that a lesion began to appear above the vaccination site on the arm 2 weeks after the vaccination, and a second lesion appeared on the chin 2 months later. responses in the lymphocyte transformation test to sonicated mycobacterium leprae, bcg, and to ppd were consistent with a tuberculoid leprosy infection. precipitation of b ... | 1981 | 7195879 |
| detection of mycobacterial lipids in skin biopsies from leprosy patients. | thin-layer chromatography was used to compare lipid extracts from lepromatous skin biopsies with those from normal skin and from mycobacterium leprae purified from armadillo spleen. several lipids were found in infected skin which were absent from normal skin but corresponded to lipids present in the purified m. leprae. these included mycolic acids, a 6-deoxyhexose-containing lipid (glycolipid i) and a wax ester (possibly related to the mycobacterium tuberculosis wax, phthiocerol dimycocerosate) ... | 1981 | 7196889 |
| fatal reaction to dapsone during treatment of leprosy. | a burmese boy being treated with dapsone (diaminodiphenylsulfone [dds]), 100 mg daily, for lepromatous leprosy had a fatal reaction to the drug 3 weeks after therapy was started. the clinical symptoms and progression of illness conform well to a "dds syndrome" first described in the early 1950s. although the syndrome clinically resembles infectious mononucleosis, neither epstein-barr virus nor cytomegalovirus was implicated as an etiologic agent in this case. the syndrome has been recognized dur ... | 1981 | 7235421 |
| [pathomorphologic changes in the internal organs of intact and mycobacterium leprae-infected 9-banded armadillos]. | the internal organs of nine-banded armadillos were examined histologically before and after inoculation of the animals with m. leprae. 3--4 months after the inoculation two animals developed tuberculoid structures in the lungs, liver and skin. a conclusion is made that experimental leprosy infection in nine-banded armadillos may run its course not only in the lepromatous but also in the tuberculoid form of the disease. | 1981 | 7295954 |
| [effect of antileprotic preparations on glycolytic processes in rats infected with human mycobacterium leprae]. | 1981 | 7314889 | |
| serology of leprosy. i. indirect hemagglutination test with stabilized sensitized red cells. | an indirect hemagglutination (iha) test has been described for the qualitative and quantitative detection of antibodies specific to mycobacterium leprae. aldehyde stabilized red cells were sensitized with a sonicate antigen prepared from m. leprae purified from armadillo liver. these cells were titrated against sera from patients with different types of leprosy, their healthy household contacts and patients with tuberculosis. specific antibodies were demonstrated in leprous sera by iha test afte ... | 1981 | 7334779 |
| [study of experimental leprosy in nude-mice inoculated with m. leprae--light and electron microscopic findings]. | 1981 | 6754678 | |
| hypothesis: do phases of immunosuppression during a mycobacterium leprae infection determine the leprosy spectrum? | 1981 | 6454034 | |
| inhibition of the proliferative response of peripheral blood lymphocytes to mycobacterial or fungal antigens by co-stimulation with antigens from various mycobacterial species. | soluble antigen preparations from mycobacterium leprae are reported to inhibit the response to other stimuli, of peripheral blood mononuclear cells from lepromatous leprosy cases (bl/ll) and also from tuberculoid cases (tt/bl) and normal donors. we confirm these findings and in addition, report that a similar suppressive effect is exerted by antigen from mycobacterium vaccae, mycobacterium nonchromogenicum and, to a lesser extent, mycobacterium tuberculosis and mycobactyerium kansasii. moreover, ... | 1981 | 6459289 |
| prothionamide and prothionamide-s-oxide in experimental leprosy. | 1981 | 6459296 | |
| bacterial persistence in leprosy. | bacterial persistence is the capability of microorganisms to survive in the host despite adequate antimicrobial treatment. this is a general phenomenon and has been observed during infection with a number of organisms. the subject is reviewed in relation to the treatment of leprosy. the presence of persisters in the large bacterial populations that exist in patients with lepromatous leprosy is not surprising. it is unlikely that in the near future a new drug or combination of drugs will be found ... | 1981 | 6792087 |
| the six disease of who. | 1981 | 6794841 | |
| an overview of carville research. | 1981 | 6797220 | |
| in vitro cultivation of m. leprae. | 1981 | 6797806 | |
| [reverse or inverse reaction - a present-day point]. | the reversal or inversal reactions, well studied in some research centers, is still imperfectly known, even contested or denied. this lack of knowledge has been one of the hindrances in the understanding of the mechanism of the hansenic neuritis. the evolution of the concepts about this question is studied, starting with souza lima and souza campos (1950), followed by tajiri (1955), up to the present "i reaction" of jopling, involving the "up grading" and "down grading" reactions. an interpretat ... | 1981 | 6749678 |
| an inquiry into the adoption of the term mycobacterium hansenii. | an inquiry was made among various organs of the public health service of the state of s. paulo, brazil, members of the scientific council and editorial board of "hansenologia internationalis", and professors of dermatology, bacteriology, neurology, pathology and preventive medicine of brazil, having in view the possibility of using the term mycobacterium hansenii in that periodical, as a substitute for mycobacterium leprae. the results were considered favorable to the change and led to the adopt ... | 1981 | 6749680 |
| intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (b663; lamprene). | a 33 year old male nigerian presented with widespread involvement of peripheral nerves, several of which were tender and painful. nerve biopsies confirmed the presence of mycobacterium leprae in both endoneurial and perineurial areas, mainly in foamy macrophages (virchow cells), but there were also large accumulations of an amorphous, acid-fast and alcohol-fast material which was not obviously of bacterial origin. appropriate stains indicated that this had many characteristics of lipofuscin. alt ... | 1981 | 6260900 |
| evaluation of fluorescent microscopy for detection of mycobacterium leprae. | 1981 | 6166792 | |
| demonstration of antibodies reacting with different determinants on mycobacterium leprae antigen 7. | a purified preparation of m. leprae antigen 7 was used to investigate the specificity of anti-m. leprae 7 antibodies in leprosy sera in a radioimmunoassay. a solution containing arabinogalactan (ag) and arabinomannan (am) inhibited the antibodies in some sera to a great extent, whereas the antibody activity was virtually unchanged in other sera under the same conditions. these findings indicate that the antibodies are directed against different determinants on m. leprae antigen 7. antibodies aga ... | 1981 | 6168595 |
| antigen-specific suppressor cells in subclinical leprosy infection. | a two-stage in-vitro culture system was used to assay cells which suppress the lympho-proliferative response to mycobacterium leprae (ml). responses to ml, purified protein derivative of tuberculin, and streptokinase-streptodornase were preferentially suppressed by mitomycin-treated cells which had been primed with the same antigen in a 7-day primary culture. healthy subjects exposed to leprosy for more than 3 years showed strong suppression of the response to ml antigens (11 of 12 showed more t ... | 1981 | 6171698 |
| comparison of 22 species of mycobacteria by immunodiffusion against an absorbed reference leprosy serum. | lithium acetate antigenic extracts of 22 species of acetone-treated mycobacteria were tested by immunodiffusion precipitation for reactivity with a pool of sera from treated lepromatous leprosy patients (arls). this arls had been adsorbed with m. bovis (bcg, m. vaccae, cardiolipin, and lecithin to make it specific for m. leprae when used in an indirect immunofluorescence test. the arls produced two precipitin lines with m. leprae extract, one of which formed a line of identity with extracts of m ... | 1981 | 6172393 |
| do anti-leprosy drugs reach mycobacterium leprae in peripheral nerves? | 1981 | 6110969 | |
| occurrence of gamma-glutamyl transpeptidase activity in several mycobacteria including mycobacterium leprae. | gamma-glutamyl transpeptidase (gamma-gt) activity, which catalyzes the transfer of the "gamma-glutamyl" group of gamma-glutamyl compounds to several dipeptide and amino acid acceptors, was found to be present in several mycobacteria, including m. leprae, both in cell suspensions and in cell-free sonicates. glycyl d-amino acids were active as acceptors, particularly glycyl-d-alanine and alpha, epsilon-diaminopimelic acid, among the amino acids. two mycobacterial isolates obtained from biopsy mate ... | 1981 | 6114046 |
| the carbol fuchsin staining of mycobacteria in leprosy institutes of southeast asia and japan, especially the effect of "basic fuchsin" used in the carbol fuchsin formula. | 1980 | 6170625 | |
| [acid-alcohol resistance of m. leprae; importance of the staining technic in the microbiological diagnosis of leprosy]. | 1980 | 6167135 | |
| intermittent chemotherapy of experimental leprosy in mice. | in this study we assess the degree of prolonged bacteriostasis of mycobacterium leprae after temporary exposure to ehtionamide or thiacetazone, and relate this to their efficacy when administered intermittently to mice with experimental leprosy infections. the results show that temporary exposure of m. leprae to either of these drugs results in a prolonged bacteriostatic effect, but that efficacy is rapidly lost as the interval between doses is increased. using the mouse foot pad system, growth ... | 1980 | 6153254 |
| soluble blue as a counterstain in the ziehl-neelsen procedure--a brief communication. | a technique is described using soluble blue instead of the conventional methylene blue as a counterstain for the ziehl-neelsen procedure. this increases the intensity of blue staining of non-bacterial contaminants and is useful in monitoring the progress of purification of m. leprae from host tissue. | 1980 | 6154018 |
| variation of in vitro lymphocyte responses to m. leprae antigen in borderline tuberculoid leprosy patients. | 1980 | 6154019 | |
| fluorescent leprosy antibody absorption (fla-abs) test for detecting subclinical infection with mycobacterium leprae. | 1980 | 6156918 | |
| immunological aspects of leprosy: ten years' activity at the armauer hansen research institute and prospects for further work. | 1980 | 6156919 | |
| microscopic counts carried out on mycobacterium leprae and m. tuberculosis suspensions. a comparison of three staining procedures. | standard smears of heat-killed mycobacterium leprae and m. tuberculosis h37rv were counted microscopically following staining by the ziehl-neelsen, auramine, and silver-methenamine methods. the numbers of stained bacillary bodies were consistently higher in the silver-methenamine stained smears compared to the ziehl-neelsen and auramine stained smears. the auramine smears were examined under ultraviolet illumination and permitted the enumeration of the brightly fluorescent bacilli against a blac ... | 1980 | 6162812 |
| [variants of the del río hortega ammoniacal silver carbonate metallic impregnation technic with special application to i: melanin and amastigotes of trypanosoma cruzi; ii: basal membranes; iii: fungi and hansen's bacilli]. | 1980 | 6184756 | |
| case for diagnosis. | 1980 | 6772986 | |
| production of a suppressor factor by human adherent cells treated with mycobacteria. | human peripheral blood mononuclear cell (mn) proliferation and lymphokine production induced by mitogen could be inhibited by heat killed whole mycobacteria. the inhibition was induced by a wide variety of mycobacteri but not by other gram-positive or gram-negative organisms or by latex particles. proliferation and lymphokine production by adherent cell-depleted lymphocytes was not inhibited by these organisms. adherent cells treated with mycobacteria had the ability to inhibit lymphocyte blasto ... | 1980 | 6774019 |
| inhibition of the incorporation of [3h]dopa in mycobacterium leprae by desoxyfructo-serotonin. | 1980 | 6775637 | |
| an assay for antibodies in leprosy sera reacting with ribonucleoprotein (rnp), a mycobacterial ribosomal antigen, using crossed immunoelectrophoresis with intermediate gel. | the technique of crossed immunoelectrophoresis with intermediate gel has been adapted to provide a quantitative assay for antibodies to a mycobacterial ribosomal antigen termed ribonucleoprotein (rnp) antigen. this antigen is no. 1 in the m. smegmatis reference system and corresponds to antigen no. 5 of m. leprae. the assay method measures changes in the rate of migration of the reference precipitin peak caused by the addition of serum in the intermediate gel and utilizes a lepromatous serum poo ... | 1980 | 6777312 |
| antibodies to mycobacteria in human tuberculosis. ii. response to nine defined mycobacterial antigens with evidence for an antibody common to tuberculosis and lepromatous leprosy. | antibodies to mycobacterial antigens were found in the sera of 33 of 52 patients with active tuberculosis by microimmunodiffusion tests. the highest titered sera were examined by a technique in which sera are placed in an intermediate gel between a reference goat antiserum field and a gel containing the antigens separated by one-dimensional electrophoresis. special patterns caused by the presence of patient's serum during the two-dimensional electrophoresis showed that nine distinct antibodies c ... | 1980 | 6780633 |
| a possible method for improving the efficacy of dapsone. | the antileprosy drug dapsone is unable to penetrate intact mycobacterium leprae in vitro, as determined by its effect on o-diphenoloxidase in the bacilli. when combined with the peptide polylysine, the sulfone drug passes through the bacterial cell membranes, and penetrates the enzyme protein, resulting in a 100% inhibition of its activity. | 1980 | 6781921 |
| antigenic evaluation of mycobacterium vaccae in relation to mycobacterium leprae. | immunodiffusion analysis of mycobacterium vaccae indicated the presence of at least nine antigens. using the technique of fused rocket immunoelectrophoresis, at least 13 such antigens were detected. comparative analysis of the m. vaccae antigen-antibody system with similar systems established for other mycobacterial species showed that m. vaccae shared a significant number of antigens with both typical and atypical mycobacteria. these included the already described beta and delta antigens that a ... | 1980 | 6782031 |
| cultivation of m. leprae in cell-free, semi-synthetic media. | attempts to cultivate m. leprae in cell-free, semi-synthetic media of various forms with lowered oxidation-reduction potential after due consideration of the biological significance of the acid-fastness of mycobacteria, resulted in the growth of this organism to the extent of visible to the naked eye. studies on the nutritional requirements at 30 degrees c, suggesting to have quite similar enzyme system as other bacterial species, if not quantitatively, but at least qualitatively. successful cul ... | 1980 | 6782814 |
| [a model for growing mycobacteria from leprous tissues placed in aliphatic hydrocarbons, tetradecane, a preliminary report]. | strains of mycobacteria were regularly cultured from human and armadillo lepromata in liquid media, supplemented with tetradecane and dimethylsulfoxide. these substances had to be emulsified with heavy inoculum in order to obtain positive subcultures in the tetradecane-dmso media. the use of nonpurified suspension of host-grown cells was advantageous for the primary cultivation. subcultures were grown in the inorganic salt-tetradecane-dimethyl-sulfoxide liquid media. strains did not grown on löw ... | 1980 | 6782815 |
| failure to detect o-diphenoloxidase in cultivable mycobacteria obtained from feral armadillos. | 1980 | 6783793 | |
| effect of mycobacterium leprae on lymphocyte proliferation: suppression of mitogen and antigen responses of human peripheral blood mononuclear cells. | evidence is presented that mycobacterium leprae suppresses the in vitro proliferative response of human peripheral blood mononuclear cells (pbm) to antigen and mitogen. lymphoproliferation induced by ppd or alloantigen stimulation was inhibited by concentrations of m. leprae which were not cytotoxic for lymphoblasts. in contrast, the inhibition of mitogen-stimulated pbm was seen only at higher concentrations of m. leprae which proved to be cytotoxic for lymphoblasts. the inhibitory effect was fo ... | 1980 | 6449337 |
| natural suppressor cells in human leprosy: the role of hla-d-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses. | six families with hla-d-identical siblings suffering from leprosy were studied. lymphocytes and macrophages isolated from the peripheral blood were co-cultured with allogeneic, hla-d-identical cells and stimulated with m. leprae antigens and concanavalin a. tuberculoid patients had circulating lymphocytes which showed marked functional suppression of lymphoproliferative responses to antigen and mitogen. in contrast, lepromatous patients showed weak lymphocyte suppressor activity. macrophages der ... | 1980 | 6451335 |
| mechanism of action of the folate blocker diaminodiphenylsulfone (dapsone, dds) studied in e. coli cell-free enzyme extracts in comparison to sulfonamides (sa). | the antibacterial activity of dds has been studied in whole cell (e. coli), cell-free folate synthesizing enzyme extracts and compared to effects obtained for sulfonamides (sa). it is shown that dds acts as a synthetase inhibitor in the folate synthesizing enzyme system. dds reacts with the substrate 7,8-dihydro-6-hydroxymethylpterinopyrophosphate to form a 7,8-dihydropteroic acid analog. bacterial growth kinetic studies were performed to test for possible synergistic activity of the analog in c ... | 1980 | 6988345 |
| segmental necrotizing granulomatous neuritis of leprosy. | in leprosy, the occurrence of necrotizing nodular lesions in peripheral nerves is a relatively uncommon complication. despite clinical and gross similarities, there are microscopical differences among groups of such cases, indicating that in all probability different pathogenetic mechanisms are operative. furthermore, the vast majority of such cases are not true abscesses but are characterized by caseous necrosis and granulomatous inflammation. the traditional collective name "nerve abscess" is ... | 1980 | 6988346 |
| vaccination in leprosy--observations and interpretations. | 1980 | 6988347 | |
| mechansism of action of dds. | 1980 | 6988348 | |
| at twenty years after shepard's method of inoculation of m. leprae in the foot pads of mice. | 1980 | 6988350 | |
| naturally occurring leprosy-like disease of wild armadillos: ultrastructure of lepromatous lesions. | 1980 | 6988587 | |
| in vitro synthesis of anti-mycobacterial antibodies in biopsies from skin lesions of leprosy patients. | to demonstrate local synthesis of anti-mycobacterium leprae antibodies, biopsies from skin lesions of leprosy patients were cultured in vitro in a medium containing 14c-labeled lysine and isoleucine, and the culture fluids were analyzed by crossed immunoelectrophoresis with intermediate gel and autoradiography. the results show that anti-m. leprae antibodies were synthesized in vitro in the biopsies from the skin lesions of leprosy patients and that the specificity of the locally produced antibo ... | 1980 | 6991410 |
| new dimensions in our understanding of the transmission of leprosy and their impact on priorities in leprosy control. | 1980 | 6991810 | |
| borderline tuberculoid leprosy with a 'lepromatous' nodule of the nasal mucosa: a case report. | 1980 | 6991811 | |
| thyroxine and leprosy. | 1980 | 6991812 | |
| study of evolution of nerve damage in leprosy. part iii--sciatic nerve lesions in mice inoculated with m. leprae with nerve conduction velocity correlates. | non-immunosuppressed swiss mice inoculated with 5000 m. leprae in each hind foot pad were subjected to nerve conduction velocity studies followed by light and electron microscopy and fibre tease of both sciatic nerves at sequential time intervals from the 4th to the 24th month. the conduction velocity was standardized for basal temperature of 35 degrees c and uninoculated mice were used as controls. progressive changes were noted in conduction velocity from the 6th post inoculation month and cor ... | 1980 | 6991814 |
| study of evolution of nerve damage in leprosy. part iv--an assessment. | 1980 | 6991815 | |
| intermittent rifampicin therapy in lepromatous leprosy. | a double blind trial involving intermittent administration of rifampicin in addition to daily dds has been undertaken in order to evaluate the efficacy as also the potential dangers of such a regimen. twenty untreated ll cases who were otherwise healthy were included in the study. ten cases received weekly 900 mg rifampicin for 6 weeks in addition to 100 mg daily dds, while the rest were treated likewise but were given similar looking placebo capsules instead of rfp. a nine month follow-up, as a ... | 1980 | 6991816 |
| [treatment of lepromatous hansen disease with a rifampicine-isoprodian association (author's transl)]. | thirty lepromatous patients were treated during 3 months. if clinical condition was notably improved, the bacillary index and the morphologic index remained almost un-changed and the histo-pathological features, advanced concurrently to the clinic aspects. | 1980 | 6991851 |
| ultrastructure of cells of the mononuclear-phagocyte series (mps) across the leprosy spectrum. | a systematic ultrastructural study of cells of the mps across the spectrum of leprosy has been carried out. graded changes in macrophage ultrastructure from the lepromatous to the tuberculoid poles have been shown. mycobacteria-filled macrophages in lepromatous leprosy are characterised by long cell processes, whereas in borderline tuberculoid leprosy these cells have a rounded appearance and are mainly characterised by numerous intracellular vacuoles. in borderline leprosy, macrophages have an ... | 1980 | 6993638 |
| myelination around multiple axons in the peripheral nerve. an unusual ultrastructural observation. | electron micrographs have been presented, demonstrating myelin ation around multiple axons. this is an exception from the normal 1:1 relationship of axon to schwann cell in a myelinated peripheral nerve fibre. | 1980 | 6994423 |
| [security measures recommended for the preparation of lepromine: who memorandum]. | 1980 | 6994912 | |
| activation of the alternative pathway of complement by mycobacteria and cord factor. | the ability of a number of mycobacteria and some of their components to activate complement was examined. mycobacterium bovis bcg (glaxo strain), mycobacterium leprae, mycobacterium lepraemurium, and cord factor activated the alternative pathway of complement in normal human serum and normal and c4-deficient guinea pig sera and generated biologically active products. bcg (pasteur strain) and muramyl dipeptide did not activate complement. the relevance of activation of complement by mycobacteria ... | 1980 | 6995341 |
| striated muscle in four categories of leprosy. ii. fine structural changes. | fine structural changes are described in 21 muscle biopsy specimens from patients with early and established tuberculoid or treated and untreated lepromatous leprosy. the predominant light microscopic finding on paraffin sections of atrophy of the muscle fiber was confirmed in semithin araldite sections, which also revealed considerable degenerative changes in a few or more fibers. these were more clearly seen in ultrathin sections, especially in the lepromatous muscle specimens. the degeneratio ... | 1980 | 6995357 |
| biochemical alteration in cells following phagocytosis of m. leprae--the consequence--a basic concept. | when macrophages from lepromatous leprosy patients are exposed to m. leprae, the macrophages show reduced protein synthesis. such a phenomenon is not seen with macrophages from tuberculoid patients or normal individuals. m. leprae phagocytized by schwann cells affect the incorporation of dna precursor in the cells, leading to failure of schwann cell association with axons in in vitro cultures. these 2 observations form a basis of proposing that basic biochemical events take place when m. leprae ... | 1980 | 6995358 |
| organized nerve culture. i. a technique to study the effect of m. leprae infection. | neonatal dorsal root ganglia were cultivated in vitro by the technique of murray. within a week bundles of organized nerve fibers containing proliferating schwann cells in different phases of axon association and fibroblast cells destined to become peri- or endoneural cells were obtained, peri- or endoneural cells were obtained. many of these nerve fibers were myelinated within 3-4 weeks. such 1 or 2 week old cultures were inoculated with m. leprae, and bacilli were found in the cytoplasm of sch ... | 1980 | 6995359 |
| organized nerve culture. ii. dna synthesis in schwann cells in the presence of m. leprae. | schwann cells that contain m. leprae fail to incorporate dna precursor, indicating blockage of dna synthesis. such a block could lead to no proliferation of schwann cells, an essential requirement for successful association with axons and consequent myelination. | 1980 | 6995360 |
| significance of immune reactions in leprosy. | 1980 | 6995566 | |
| immunology of leprosy. | 1980 | 6996917 | |
| delineation of a human t cell subset responsible for lepromin-induced suppression in leprosy patients. | 1980 | 6997379 | |
| immune response to mycobacterium leprae: further studies on the assessment of humoral immune response in mice. | immuncyte proliferation in the spleens of mice given both a primary and a second infection sixty days later, was detected soon after the second challenge was administered. plaque-forming cell assay for both the direct and developed plaques indicated that all cells producing antibody of both immunoglobulin classes were present in the animals when they were administered the second challenge. hemagglutinating antibody determinations indicated that igg antibodies are recognizable at a time when the ... | 1980 | 6999803 |
| effect of purification steps on the immunogenicity of mycobacterium leprae. | in studies aimed at the development of an antileprosy vaccine for use in man, mycobacterium leprae suspensions were prepared from livers of experimentally infected armadillos. the 2 methods of purification in chief use, carried out after irradiation of the tissue with 2.5 megarads of gamma irradiation from 60co, involved treatment with 0.1n naoh for 2 h at room temperature, trypsin and chymotrypsin digestion for 24h at 37 degrees, and separation in a 2-phase liquid polymer (dextran:polyethylene ... | 1980 | 7000133 |
| searches among mycobacterial cultures for antileprosy vaccines. | all mycobacteria species share some antigens, so there may be cultivable mycobacterial cultures that can provide vaccine protection against leprosy. vaccine protection against mycobacterium leprae infections in mice has been demonstrated for m. leprae itself, as living or heat-killed suspensions, and for mycobacterium bovis (bcg), as living suspensions. results are reported here with 17 other cultures. the mycobacterial suspensions were injected intradermally, and the mice were challenged in the ... | 1980 | 7000701 |
| the suppressive effect of m. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy. | peripheral blood lymphocytes from sixty leprosy patients and eight healthy contacts known to be responsive to m. leprae, were stimulated in vitro with concanavalin a (con a) or ppd alone or in combination with autoclaved, whole m. leprae. time kinetics and the percentage of inhibition induced by m. leprae differed in the two disease groups and contacts. antigen-generated suppression of con a-stimulated lymphocyte transformation was observed on day 4 in seventeen of twenty-one (80%) tuberculoid p ... | 1980 | 7002396 |
| viability of mycobacterium leprae after multiplication in mice. | to measure the rate at which mycobacterium leprae are killed in the course of the mouse footpad infection after the maximum of multiplication has been achieved, m. leprae were harvested shortly before and at intervals after multiplication had reached the level of 10(6) organisms per footpad, serially diluted, and inoculated into the footpads of passage mice. beginning 1 year later, foot-by-foot harvests of m. leprae were performed from passage mice, and the proportion of viable organisms in the ... | 1980 | 7002795 |
| comparative studies of antigen 21 in mycobacterium and nocardia species: possible taxonomic relationships with mycobacterium leprae. | studies of mycobacterium leprae, mycobacterium tuberculosis and nocardia caviae in comparison with each other and with other mycobacterium and nocardia species were performed on the basis of antigen 21 intramolecular heterogeneity. three different antisera were used: rabbit anti-mycobacterium smegmatis antiserum, rabbit anti-nocardia asteroides antiserum, and a lepromatous serum pool. with reference to each of the three antiserum sources used the strains were ranked in an order of relatedness or ... | 1980 | 7002798 |
| detection of antigen in nocardia caviae cross-reacting with mycobacterial antigen no. 21 in m. leprae using a lepromatous leprosy serum pool as antibody reagent. | eighteen strains of nocardia, representing five different species, were studied in crossed immunoelectrophoresis against a lepromatous leprosy serum pool for the presence of antigen no. 21. this mycobacterial antigen shows antigenic heterogeneity with species specific antigenic determinants defined in mycobacterium leprae. all four strains of n. caviae were found to share antigen no. 21 determinants with mucobacteria. all other strains of nocardia were negative in these direct immunoprecipitatio ... | 1980 | 7002810 |
| combined rifampin and dapsone chemotherapy of mycobacterium leprae infection of the neonatally thymectomized lewis rat. | neonatally thymectomized lewis rats (ntlr) were shown to be highly susceptible to infection with mycobacterium leprae. we have used them in chemotherapeutic studies as models of human lepromatous leprosy. ntlr chronically infected with m. leprae were treated with various regimens combining a background of the minimal effective dose (med) of dapsone (4,4'-diaminodiphenylsulfone, dds) or 100 times this dose in the diet with one to ten doses of rifampin (rmp) of 10 mg/kg. to test for persisting via ... | 1980 | 7002811 |
| the transmission of leprosy in man. | existing clinical, scientific, and epidemiological knowledge on the mode of transmission of human leprosy is reviewed under the following headings: a. the release of viable organisms from the host into the environment. b. the presence of viable organisms so released into the environment. c. entry into the new human host and distribution within the body. d. production of clinical illness. it is concluded that much of the published evidence deals with one, or rather few, parameters, whose relation ... | 1980 | 7002813 |
| effect of purification procedures on the viability of mycobacterium leprae. | 1980 | 7002817 | |
| [control of leprosy: fantasies and possibilities]. | 1980 | 7004552 | |
| conversion of reactions to leprolin and lepromin in patients with lepromatous leprosy by the transfer factor. | conversion of leprolin and early lepromin reactions was achieved by two injections of transfer factor made of lymphocytes from lepromin-positive tuberculoid leprosy patients. however, the late reaction to lepromin remained unchanged. the importance of the degree of sensitivity of the cell donor was demonstrated, and a booster dose was also found to be useful. the feasibility of using transfer factor in treatment of lepromatous leprosy is briefly discussed. | 1980 | 7004800 |
| macrophage culture from untreated leprosy cases. | macrophage cultures from the peripheral blood were performed in 25 untreated bacteraemic leprosy patients. the monocytes on conversion to macrophages in culture continued to harbour solidly stained m. leprae till the termination of culture. it is suggested that the majority of these bacilli are viable and capable of multiplication intracellularly in macrophages if cultures could be maintained for sufficiently long periods. it was observed that bacteraemia in leprosy can be detected by the cultur ... | 1980 | 7005539 |
| life cycle of mycobacterium leprae. | 1980 | 7005541 | |
| secondary sulphone resistance in leprosy (report of a case). | a case of secondary sulphone resistant lepromatous leprosy proved by mouse foot-pad tests is reported from pondicherry, india. | 1980 | 7005542 |
| antibodies against mycobacterium leprae antigen 7 from birth to 18 months of age: an indicator of intra-uterine infection in leprosy. | all babies of three non-leprosy mothers and ten tuberculoid leprosy mothers and four of five babies of mothers with inactive lepromatous leprosy showed a decline in serum concentration of antibodies against m. leprae antigen 7 during the first 4 months of life, as expected from catabolism of maternal igg. by contrast, ten of twenty babies of mothers with active lepromatous leprosy showed a decline in concentration of anti-m. leprae 7 antibodies considerably less than expected. this indicates tha ... | 1980 | 7006873 |
| lucio's phenomenon. | a 38-year-old woman had diffuse, nonnodular, lepromatous leprosy and lucio's phenomenon. most cases of lucio's phenomenon have been reported to have a leukocytoclastic vasculitis as the underlying pathologic abnormality. in this patient, however, the histologic picture of an early lesion of lucio's phenomenon showed a milk, mononuclear cell infiltration, endothelial swelling, vascular thrombosis, and ischemic necrosis. lepra bacilli were abundant around nerves and blood vessels, and many were no ... | 1980 | 7356353 |
| leprosy in a chimpanzee. postmortem lesions. | a young (5-7 year old) male chimpanzee died 33 months after the first clinical manifestations of a naturally acquired disease that was similar to disseminated leprosy in man. at autopsy there were diffuse or multifocal histiocytic infiltrations of the skin, nasal mucosa, pharynx, lung interstitium, liver, spleen, sclera, testicles, adrenal glands, and peripheral lymph nodes. major nerves of the forearms had extensive fibrosis. there were large numbers of acid-fast bacilli (afb), many occurring a ... | 1980 | 7193655 |
| [maintenance of armadillos in captivity and results of the inoculation of mycobacterium leprae]. | the authors report their experiences in raising armadillos and the results obtained in inoculating them with m. leprae. they begin by reporting on the origin of the animals, how they were captured, and their efforts until they found the right kind of housing for the armadillos. they also tell of their attempts to develop the correct feeding procedures. the result is the feed used now in their laboratory: chicken feed mixed with bread, eggs, meat and milk. along with this, they report on the way ... | 1980 | 7042562 |
| identification of mycobacterium leprae: use of wall-bound mycolic acids. | a simple method for extraction and analysis of wall-bound mycolic acids from small samples of mycobacteria is described. separation of mycolic acid classes according to their functional groups by thin-layer chromatography showed a difference between mycobacterium leprae and a number of strains of acid-fast bacilli cultured from leprosy biopsies in vitro. this technique is proposed as a convenient preliminary test in the identification of possible cultures of m. leprae. | 1980 | 7019389 |
| hydrocarbons of petroleum: ideal substance for mycobacteria. | 1980 | 6789600 | |
| combined chemotherapy against mycobacterium leprae in the mouse. | 1980 | 7018423 | |
| the immunogenicity of killed mycobacteria. | 1980 | 7012498 | |
| preliminary immunological studies in search of correlates of protective immunity carried out on some iranian leprosy patients and their families. | 1980 | 7012499 | |
| dapsone-resistant leprosy in a population of bamako (mali). | 1980 | 7012500 | |
| assaying dapsone in mouse diets. | 1980 | 7012501 | |
| quantitative study of the separation of mycobacterium leprae from armadillo tissue. | 1980 | 7012502 | |
| cultivable precursors of mycobacterium leprae. | during attempts at test tube culture of m. leprae in our laboratory we have repeatedly isolated a non-acid fast, coccoid organism from lepromatous tissue and skin smears (chatterjee, 1976). these organisms show a tendency to generate acid fast mycobacteria in test tube passages and in mice experimentally infected with these organisms, and a number of stable, pigmented mycobacterial cultures have been obtained from them that are being maintained in test tube media. in the first report cited above ... | 1980 | 7007724 |
| choice of skin slit smears for study of bacterial and morphological indices. | skin slit smears of 46 patients of lepromatous leprosy (16 untreated, 30 long treated) were studied from ear lobules, fingers, elbows and knees. in untreated patients ear lobules gave highest bi, as compared to other sites. mi from ear lobules was higher than elbows and knees but slightly lower than that from fingers. in treated patients sites other than ear lobules yielded solid staining bacilli more frequently. multiple sites and especially peripheral sites are recommended for study of skin sl ... | 1980 | 7007725 |
| third annual report of the undp/world bank/who special programme for research and training in tropical diseases. | 1980 | 7007726 | |
| demonstration of antibodies against mycobacterium leprae both in immunoglobulin g and m in sera from pregnant and non-pregnant lepromatous leprosy patients. | 1980 | 7007768 |