Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| the mycolic acids of mycobacterium leprae harvested from experimentally infected nine-banded armadillos. | mycolic acid methyl esters were prepared from defatted cells of armadillo-derived mycobacterium leprae and analysed by thin-layer and high-performance liquid chromatography, proton magnetic resonance spectrometry and mass spectroscopy. the first type of mycolic acid characterized was an "alpha-mycolate" having two cis-cyclopropane rings, a 78-carbon main component and an overall size-range of 72 to 83 carbons. ketomycolates, with an 83-carbon main component, were the only other type of mycolate ... | 1982 | 7051928 |
| [comparative study of the lipids of mycobacterium leprae and other strains of mycobacteria]. | 1982 | 7051929 | |
| the who leprosy programme. | 1982 | 7051930 | |
| mycobacterium leprae and other mycobacteria difficult to culture. | 1982 | 7051931 | |
| mycobacterial lipids in infected tissue samples. | mycobacteria synthesize characteristic lipids which can readily be distinguished from those synthesized by the host cells which they infect during pathogenesis. this fact can be exploited to provide information about mycobacteria growing in infected tissue samples: (a) qualitative analysis of lipid extracts from lepromatous leprosy skin biopsies reveals the presence of several mycobacterial lipids including an m. leprae-specific glycolipid, phthiocerol dimycocerosate and mycolic acids; (b) quant ... | 1982 | 7051932 |
| ultrastructural alterations of mycobacterium leprae in skin biopsies of untreated and treated lepromatous patients. | 1. -- mycobacterium leprae cells under a process of progressive disaggregation are present in the skin of both treated and untreated patients. 2. -- the ultrastructural alterations observed during the degenerative process seem to be qualitatively similar in treated and untreated patients. 3. -- the proportion of altered m. leprae cells increases during the treatment, mainly with rifampicin and rifampicin + clofazimine + diaminodiphenyl sulfone. 4. -- the cell wall of m. leprae is the last bacter ... | 1982 | 7051933 |
| adsorption of mycobacteriophages on mycobacterium leprae: taxonomic significance. | the following bacteriophages were shown to adsorb on mycobacterium leprae: bk1, clark, sedge, baits, watson and d29. bacteriophages that did not adsorb on the leprosy bacilli were bg1, legendre, marshall, panetti, leo and wiseman. the taxonomic significance of these findings and some prospective consequences of these investigations are discussed. | 1982 | 7051934 |
| anomalous isoenzymes of lactate dehydrogenase in sera of patients with leprosy. | in an earlier study (saoji et al, 1980) we looked for anomalous (additional) isoenzymes in homogenates of 17 active and 25 of regressing lepromatous leprosy, three of erythema nodosum leprosum, eight of bt, 19 of tt and one of indeterminate leprosy. anomalous bands were found in 17 cases. they correlated with large numbers of viable organisms and were thought to originate from mycobacterium leprae. this communication describes the serum ldh isoenzymes of the same 78 cases. six of 17 cases with a ... | 1982 | 7098443 |
| bacteriological studies of armadillo livers infected with mycobacterium leprae. | 1982 | 7181543 | |
| thymus-dependent lymphocytes in leprosy. ii. effect of chemotherapy on t-lymphocyte subpopulations. | the basis of the immunological unresponsiveness seen in leprosy patients is unknown. untreated lepromatous leprosy patients display an unspecific cellular anergy which disappears with treatment, leaving an anergy specific for mycobacterium leprae. these patients suffer from a complication, erythema nodosum leprosum, characterized by a recurrent eruption of tender skin nodules disappearing in 2 to 3 days. these nodules show a histological picture reminiscent of an arthus reaction. erythema nodosu ... | 1982 | 7040440 |
| leprosy. | 1982 | 7040711 | |
| reversion of the downhill course of active lepromatous leprosy by repeated transfusions of fresh blood, donated by healthy but lepromin positive patients. | earlier studies of immunologic reconstitution therapy of active lepromatous leprosy patients by repeated infusions of viable allogeneic blood lymphocytes indicated a beneficial effect. in order to avoid cell separation and its associated risks, we attempted to transfer immunity passively into seven seriously ill lepromatous patients by repeated transfusions of fresh blood donated by healthy, but tuberculin and lepromin positive, subjects. the results showed clinical improvement in some cases wit ... | 1982 | 7041343 |
| [pathogenic mycobacteria]. | it is well established that mycobacteria other than tubercle bacilli and m. leprae are important human pathogens. at least 15 species comprise all the presently known mycobacterial pathogens of man. eleven species are potential pathogens because disease production often dependent on special factors of the human host. the comments include some characterization of the mycobacteria, especially of the potential pathogenic species. a summary of important nontuberculous mycobacterial diseases of man i ... | 1982 | 7041441 |
| immunoglobulin class specific antibodies to m. leprae in leprosy patients, including the indeterminate group and healthy contacts as a step in the development of methods for sero-diagnosis of leprosy. | iga, igm and igg anti-m. leprae antibody activity was quantitated by solid phase radioimmunoassay in groups of untreated leprosy patients throughout the spectrum, in lepromatous leprosy patients treated for more than 10 years, in an indeterminate leprosy group, and in a non-leprosy control group. iga, igm and igg anti-m. leprae antibody activity increased from the group of healthy individuals exposed to m. leprae but without clinical signs of leprosy to tuberculoid (bt and bt/tt) and further to ... | 1982 | 7042137 |
| demonstration of mycobacterial antigens in leprosy tissues. | biopsies from 69 patients with leprosy were stained to demonstrate mycobacterial antigens using immunoperoxidase methods. the same biopsies were cut and stained using fite-faraco, triff and hematoxylin-eosin for classifying the patients and to demonstrate mycobacteria. since m. leprae and bcg show extensive antigenic cross reactions, anti-bcg antibodies were used as primary antisera to demonstrate cross-reacting antigens of m. leprae. cross-reacting mycobacterial antigens were, thus, found in al ... | 1982 | 7042609 |
| bacterial growth kinetics of "m. lufu" in the presence and absence of various drugs alone and in combination. a model for the development of combined chemotherapy against m. leprae? | bacterial growth kinetic studies were performed in a series of potential inhibitors of m. leprae using "m. lufu" as a model strain. reasons why "m. lufu" is considered to be a better model than m. tuberculosis are presented. the inhibitory power of the single drugs has been quantified, the activity constants are calculated, and the synergistic, additive, or antagonistic behavior of the combinations is evaluated. it is demonstrated that a combination consisting of dapsone (dds), prothionamide (pt ... | 1982 | 7042611 |
| ultrastructural features of the multiplication of human and murine leprosy bacilli in macrophages of nude mice. | ultrastructural features of the growth of m. leprae and m. lepraemurium in nude mouse macrophages were studied by ultrathin sectioning and freeze-etching. in nude mouse macrophages, m. leprae produced spherical droplets (foamy structures) similar to those in human lepra cells. on the other hand, m. lepraemurium produced typical crystalline material in nude mouse macrophages, which is quite the same as that observed in the c3h strain mouse, spherical droplets in the form of foamy structures seem ... | 1982 | 7042613 |
| ultrastructural characteristics of mycobacterium bovis bcg and mycobacterium leprae. | freeze-fracture studies (ff) and ultrathin sectioning (uts) have been performed on mycobacterium bovis (bcg) and mycobacterium leprae (ml). ff of bcg revealed the presence of two populations of cells: one group having four fracture faces and the other showing only two; the latter showed a preferential cleavage along a plane across the cell wall (cw) having a smooth appearance devoid of particles, on both protoplasmic (pf) and exoplasmic (ef) fracture faces. on the other hand, ff of the plasma me ... | 1982 | 7042614 |
| adenosine triphosphate content of mycobacterium leprae: effect of purification procedures. | various procedures to decontaminate and purify m leprae free of host tissue material resulted in total retention of their intracellular atp and also infectiousness. the atp content of one million m. leprae cells, isolated from either livers, spleens, or lymph nodes of infected armadillos, or a nude mouse foot pad or a human biopsy specimen, was in the range of 1.17 to 1.40 picograms. suspensions could be decontaminated with 4% naoh and all non-bacterial atp could be eliminated by the combined ac ... | 1982 | 7042615 |
| statistical analysis of results obtained by two methods for testing drug activity against mycobacterium leprae. | 1982 | 7042616 | |
| preliminary studies of the metabolic activity of purified suspensions of mycobacterium leprae. | mycobacterium leprae isolated from armadillo tissue incorporated radioactivity from d-(14c)glucose and (14c)protein hydrolysate. in the presence of glucose, the rate of incorporation of (14c)protein hydrolysate was increased. uptake of glucose was inhibited by 2-deoxy-d-glucose and sodium azide; that of the amino acids was inhibited by puromycin and chloramphenicol and, weakly, by cycloheximide. | 1982 | 7042905 |
| immunological implications of necrotic, cellular and vascular changes in leprous neuritis: light and electron microscopy. | 1982 | 7043135 | |
| rapid, radiolabeled macrophage culture method for detection of dapsone-resistant mycobacterium leprae. | mycobacterium leprae cells extracted from the skin biopsies of 14 bacilliferous lepromatous patients were maintained in human-murine macrophage cultures for 3 weeks in the presence of [3h]thymidine and dds (4,4'-diaminodiphenyl sulfone). all cultures except one containing freshly extracted viable bacilli showed significant incorporation of [3h]thymidine as compared to control cultures containing heat-killed bacilli of the corresponding strain. six susceptible strains of m. leprae obtained from u ... | 1982 | 7044299 |
| "pro-eu-karyote" graft acceptance: a mechanism for intracellular parasitism - a new hypothesis for pathogenesis of leprosy. | 1982 | 7045602 | |
| the origin, morphology, and function of epithelioid cells. | epithelioid cells are cells of the mononuclear phagocyte system found in certain granulomas mainly associated with intense immunological activity. these cells show little phagocytic activity. in certain experimental granulomas such as those produced in guinea pigs sensitive to zirconium, and at sites of intense inflammatory reaction in man, they may contain varying amounts of rough endoplasmic reticulum ("secretory" epithelioid cells). in other situations such as tuberculoid leprosy and in some ... | 1982 | 7047374 |
| humoral immunity in leprosy: immunoglobulin g and m antibody responses to mycobacterium leprae in relation to various disease patterns. | a solid-phase radioimmunoassay, applying whole mycobacterium leprae as antigen and radiolabeled protein a from staphylococcus aureus as antibody-detecting reagent, was used for the determination of specific immunoglobulin g (igg) and igm antibody responses in leprosy patients. high igg anti-m. leprae antibody levels were found in lepromatous leprosy patients, whereas the antibody response in tuberculoid leprosy patients varied from negative, i.e., comparable with responses measured in normal ind ... | 1982 | 7047400 |
| the clinical diagnosis of dapsone resistant leprosy. | for the early recognition of dapsone resistance, it is essential to regularly examine patients at risk for suspicious new lesions, backed by regular clinical treatment records including smear results. the earlier the recognition and starting on alternative treatment, the better is the response. however, it is not advisable to change treatment without attempting at least clinical confirmation, and endorsing the chart so that the problem is not missed on subsequent occasions. | 1982 | 7047897 |
| histologic profile in apparently normal skin of leprosy patients. | 1982 | 7047898 | |
| effect of desoxy fructo serotonin (dfs) on the multiplication of m. leprae in mouse foot-pad. | 1982 | 7047899 | |
| a comparison of the skin scrape and skin biopsy methods in mouse foot-pad experiments with m. leprae. | 1982 | 7047900 | |
| increase in prevalence of leprosy caused by dapsone-resistant mycobacterium leprae. | 1982 | 6798411 | |
| dna isolated from mycobacterium leprae: genome size, base ratio, and homology with other related bacteria as determined by optical dna-dna reassociation. | dna derived from mycobacterium leprae (grown in armadillos) was isolated, purified, and analyzed spectrophotometrically. the genome size and the guanine-plus-cytosine content of m. leprae were 1.3 x 10(9) and 55.8%, respectively. among selected strains of mycobacterial, nocardial, and corynebacterial species, corynebacterium sp. 2628 lb, isolated from a human leprosy patient, showed the highest dna homology with m. leprae. of the dnas derived from mycobacteria, those of m. tuberculosis and m. sc ... | 1982 | 6801025 |
| detection of externally induced impairments in single bacterial cells by laser microbe mass analysis. | applying the laser microbe mass analyzer method (lamma), mass spectra (fingerprints) were taken from single bacterial cells not treated or treated with high temperature, x-irradiation, isonicotinic acid hydrazide (inh), or diaminodiphenylsulfone (dds). spectra of treated cells ("m. lufu," m. tuberculosis h37ra, e. coli) differ from those of controls in that the k+/na+ ratio was smaller and in that the intensities of peaks with m/e greater than 100 were lower. from the results with m. leprae the ... | 1982 | 6804403 |
| a comparison of the bactericidal activity of a series of rifampicins against mycobacterium leprae. | the bactericidal activity against mycobacterium leprae of six 3-(4-methylpiperazin-1-yl-iminomethyl)rifamycin sv (rifampicin) derivatives was compared with that of rifampicin in a modified proportional bactericidal test, using a smaller number of experimental animals and allowing the administration of a single dose of the drugs. no correlation was found between the in vitro activity of the rifamycin derivatives against m. tuberculosis or rapidly growing mycobacteria in vitro and the activity aga ... | 1982 | 7037013 |
| applications of flow cytometry on bacteria: cell cycle kinetics, drug effects, and quantitation of antibody binding. | 1982 | 7035105 | |
| feline leprosy: a review of forty-four cases from western canada. | forty-four files of cats diagnosed as having feline leprosy were reviewed. all except one were from along the pacific coast in the province of british columbia. the majority of cats were between one and three years of age and there was an increase in the number of diagnosis during the winter months.two types of granulomatous responses similar to the tuberculoid and lepromatous phases of human leprosy were recognized. in spite of the overall similarities in the cellular response to human leprosy ... | 1982 | 17422188 |
| the association of pregnancy and leprosy. ii. pregnancy in dapsone-resistant leprosy. | 1981 | 7035779 | |
| activity of the combination of isoniazid, protionamide and dapsone against mycobacterium leprae and some other mycobacteria. | no additive effect was found at the addition of isoniazid to either dapsone or protionamide against m. leprae and against highly dapsone-sensitive in vitro growing mycobacterium sp. strains. it is concluded that the indication of the administration of isoniazid in leprosy is extremely limited and could only be envisaged as a companion drug in combined therapy of dapsone-resistant multibacillary leprosy in light-skinned people, when aminoglycosides cannot be administered. | 1981 | 7037011 |
| serology of leprosy. ii. demonstration of specific antibodies to mycobacterium leprae by counter current electrophoresis. | a rapid and simple method for the demonstration of specific antibodies to mycobacterium leprae using counter current electrophoresis (cce) has been described. three types of antigens (sonicate antigen, surface antigen and purified protoplasmic protein antigen) were prepared from purified m. leprae and tested against sera from patients with different types of leprosy, and their healthy household contacts, by cce. antibodies specific to m. leprae were demonstrated by cce after absorption of sera w ... | 1981 | 7038297 |
| skin test response to m. leprae precursor coccoid organisms in a high leprosy endemic area as compared to lepromin. | the paper describes the results on several hundred skin tests on humans using antigens from leprosy derived non-acid fast coccoid organisms, and a mycobacterium that grew out of one of the coccoid organisms. early skin test response to the cytoplasmic fraction of one of the leprosy derived, non-acid fast, coccoid organism was very highly correlated with standard lepromin. | 1981 | 7038299 |
| inhibition of foot pad multiplication of m. leprae in mice vaccinated with leproma derived m. leprae precursor coccoid organism and passive transfer of dth response to normal mice through infusion of splenic cells of such vaccinated mice. | 1981 | 7038300 | |
| abstract of papers presented at the international symposium on mycobacterium leprae and other atypical mycobacteria. | 1981 | 7038301 | |
| [terminal innervation in 3 cases of leprous neuropathy (author's transl)]. | three cases of leprosy are reported. in all patients, the diagnosis was made by finding hansen bacilli in skin lesions, nasal secretions and ears, and the immunological typing of leprosy was established. conduction velocity of motor and sensory nerves was measured and muscle biopsies were obtained. histochemical typing of muscle fibers and measurement of the terminal innervation ratio of motor axon vitally stained with methylene blue were performed. a subclinical involvement of peripheral motor ... | 1981 | 7038820 |
| iga and igm antibodies against mycobacterium leprae in cord sera and in patients with leprosy: an indicator of intrauterine infection in leprosy. | a solid-phase radioimmunoassay was developed for demonstration and quantification of iga and igm anti-m. leprae antibodies. iga and igm anti-m. leprae antibodies were demonstrated in a lepromatous serum pool, in various amounts in individual patients with lepromatous leprosy, and in lower concentration in tuberculoid leprosy and non-leprosy controls. iga and igm anti-m. leprae antibodies were demonstrated in cord sera from babies of mothers with leprosy. the reliability of fetal iga and igm anti ... | 1981 | 7038849 |
| [lipidic constituents of "mycobacterium leprae" isolated from experimentally infected armadillo (author's transl)]. | mycobacterium leprae (obtained from experimentally infected armadillo) was submitted to saponification. the liposoluble part was methylated and fractionated by chromatographic methods. each fraction was studied by gas-liquid chromatography. cholesterol (from the infected host) and the main fatty acids were identified. mycolic acids were isolated, and their structures determined, using mass spectrometry. these structures are useful to make a comparison of m. leprae with some other mycobacteria. s ... | 1981 | 7020522 |
| paracrystalline inclusions in mycobacterium leprae. | the occurrence of paracrystalline inclusions of mycobacterium leprae infected with the mycobacteriophage d29 or treated with mitomycin c was reported before [5, 6]. in pursuing these studies we have now documented by electron micrography a number of paracrystals we thought sufficient to further describe these inclusions, and to show that they appeared to be formed in association with the intracellular membranous structures of the leprosy bacilli. | 1981 | 7020523 |
| incorporation of 3h-thymidine in mycobacterium leprae within differentiated human macrophages. | the factors influencing the incorporation of 3h-thymidine (3h-tdr) in the dna of mycobacterium leprae within macrophages derived from human blood have been evaluated. fifty strains of m. leprae derived from skin nodules of patients with lepromatous leprosy were studied for their ability to incorporate 3h-tdr. control macrophages of the same donor maintained alone, or with autoclaved m. leprae, showed low levels of baseline 3h-tdr incorporation. during a 15-day period of pulsing, 27 of the m. lep ... | 1981 | 7021836 |
| the uptake of 3h-thymidine in mycobacterium leprae inoculated mouse macrophage cultures as a rapid indicator of bacillary viability. factors influencing the specificity of the in vitro assay. | mouse peritoneal macrophages derived from balb/c were used as host cells for 17 human-derived m. leprae strains. simultaneous pulsing with 3h-thymidine (3h-tdr) showed uptake of the radiolabel in 58.8% of the bacilli over a 14 day period. preliminary data of three m. leprae strains indicate that the 3h-tdr is preferentially incorporated into the mycobacterial dna and not into the mammalian host cell dna. this in vitro assay provides a rapid assessment of m. leprae viability. the factors influenc ... | 1981 | 7024148 |
| a novel phenolic glycolipid from mycobacterium leprae possibly involved in immunogenicity and pathogenicity. | a phenolic glycolipid was obtained in high amounts (2% of dry weight) from mycobacterium leprae isolated from infected armadillo liver. infrared and nuclear magnetic resonance spectroscopy showed that it is closely related to "mycoside a" from mycobacterium kansasii and is therefore a glycosylphenolic phthiocerol diester. the crucial difference between the two products is in the composition of the attached trisaccharide. gas-liquid chromatography-mass spectroscopy showed that the product from m. ... | 1981 | 7024248 |
| a report on the biochemical analysis of mycobacterium w. | a mycobacterial strain known as mycobacterial strain w was analysed for its growth characteristics and biochemical traits. this strain was found to be a rapid grower, with luxurient growth on lowenstein-jensen medium, dubos agar, middlebrook's agar and sauton's medium. colonies were smooth, convex and nonpigmented. some of the colonies which appeared rough were similar to smooth colonies at least in biochemical characteristics. this organism was tolerant to wide range of temperatures and to chem ... | 1981 | 7024633 |
| discharge of m. leprae in milk of leprosy patients. | a quantitative estimation of discharge of m. leprae in the milk of 39 leprosy female patients has been made. twelve of the 39 patients (10 ll/bl and 1 each of t/bt and bb) showed bacilli in their milk. only one of these patients was on treatment. afb count in 10 ml of milk was found to range from 4.3 x 10(4) to 4.3 x 10(5). significance of discharge of such a large number of bacilli in breast milk is discussed. | 1981 | 7024634 |
| fourth annual report of the undp/world bank/who special programme for research and training in tropical diseases. | 1981 | 7024635 | |
| the immunology of leprosy: speculations on the leprosy spectrum. | leprosy is a chronic infectious disease caused by mycobacterium leprae. the disease presents a wide spectrum of clinical manifestations, ranging from lepromatous to tuberculoid leprosy; each form may be punctuated by episodes of acute exacerbation, called reactional states. these polar forms and reactional states appear to be determined by immunologic interactions between the host and the microorganism. this review describes the different measurable parameters that permit the classification of a ... | 1981 | 7025147 |
| studies of lysosomal enzymes in macrophages. iii. lysosomal enzyme activities in cultured macrophages infected with some species of mycobacteria. | 1981 | 7028685 | |
| [difference in infectivity of mycobacterium leprae from patients in immunosuppressed mice (author's transl)]. | 1981 | 7028712 | |
| [problems in designing a protocol for a leprosy vaccine trial. (author's transl)]. | investigations carried out by the scientific working group on immunology of leprosy (immlep) have led to the planning of field trials of an experimental vaccine preparation to be carried out in few years' time. the objectives of these trials have been defined as follows: 1) the main objective should be the assessment of the protective effect of the vaccine against leprosy, its various forms and more particularly the lepromatous form. 2) another important objective will be to determine the value ... | 1981 | 7029677 |
| [studies on the lipids of "mycobacterium gordonae" in comparison with those of "m. leprae" and of some other scotochromogenic mycobacteria (author's transl)]. | the mycolic acids were isolated from mycobacterium gordonae (strain atcc 14470), and purified by thin layer chromatography. three species were studied by mass spectrometry. the analogy between m. gordonae and m. leprae, based on the lack of tuberculostearic acid, was supported by the comparison of the structures of their mycolic acids. succinct analyses of the lipids of three other scotochromogenic strains of mycobacteria, using thin layer chromatography and gas-liquid chromatography, were perfo ... | 1981 | 7030172 |
| the mycobacterium smegmatis peroxidase, cross-reacting antigen with mycobacterium leprae. | 1981 | 7030274 | |
| potential anti-leprosy vaccine from killed icrc bacilli--a clinicopathological study. | 1981 | 7030942 | |
| the effect of body temperature and cell-mediated immunity on the growth of mycobacterium marinum and mycobacterium leprae in mice. | evidence is presented that the high susceptibility of armadillos to infection with mycobacterium leprae cannot be explained solely in terms of body temperature because mutant mice maintained with a body temperature similar to that of armadillos do not become heavily infected with m. leprae. the depression of cell-mediated immunity accompanying the low body temperature is not sufficient to produce an overwhelming infection. the results obtained with m. marinum suggest that whereas lack of cell-me ... | 1981 | 7031255 |
| a brief review of experiences with short-term clinical trials monitored by mouse-foot-pad-inoculation. | 1981 | 7031389 | |
| pharmacologically-active mediators of hypersensitivity reactions in the blood of lepromatous patients with erythema nodosum leprosum. | 1981 | 7031390 | |
| release of soluble factors from lymph nodes containing mycobacterial granulomas and their effect on fibroblast function in vitro. | 1981 | 7032710 | |
| the effect of delayed addition of antigen and 'e' rosetting on the proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal individuals or from patients with tuberculosis or leprosy. | some suppressor cells are reported to lose their activity when precultured without stimulus in vitro. we have investigated the role of such suppressors in responsiveness to mycobacterial antigens of peripheral blood mononuclear cells (pbmnc) from patients with leprosy or tuberculosis, or from normal donors. delayed addition of mycobacterial antigens (mycobacterium leprae, mycobacterium vaccae and mycobacterium tuberculosis), but not of a fungal antigen (candida albicans) caused enhanced response ... | 1981 | 7033116 |
| relationship between t-cell population in neonatally thymectomized lewis rats and susceptibility to infection with mycobacterium leprae. | the neonatally thymectomized lewis rat (ntlr) is highly susceptible to infection with m. leprae. however, a significant percentage of ntlr respond to infection with m. leprae in much the same way as do intact rats, yet show no evidence of residual thymus. to determine whether there was a correlation between the number of remaining t-cells and susceptibility to infection with m. leprae, a direct fluorescent antibody test was performed using a highly specific, absorbed antithymocyte globulin label ... | 1981 | 7033149 |
| experimental mycobacterial granulomas in guinea pig lymph nodes: ultrastructural observations. | a systematic ultrastructural study has been performed of the mononuclear phagocytes in granulomas induced by different types of mycobacteria, e.g. live bcg (pasteur), irradiated m. leprae and irradiated bcg (pasteur) in guinea pig lymph nodes. live bcg (pasteur) induces a granuloma which peaks at 2-3 weeks and by light microscopy, a large number of the infiltrating cells have the appearance of epithelioid cells. ultrastructurally a large proportion of these cells have a distinct appearance. they ... | 1981 | 7033491 |
| [studies on m. leprae isolated from the lymph of a lepromatous patient using the freeze-fracture technic]. | 1981 | 7034060 | |
| induction of delayed-type hypersensitivity to mycobacterium leprae in healthy individuals. | delayed-type hypersensitivity (dth) to a soluble mycobacterium leprae skin test antigen (sml) was successfully induced in healthy volunteers following immunization with 2 x 10(8) killed armadillo-derived m. leprae. no better sensitization was obtained by a mixture of live bcg and killed m. leprae. the relative specificity of the dth reaction to sml has been demonstrated in this study, since little cross-reactivity was observed to ppd, after immunization with bcg ro m, leprae alone, or combined. ... | 1981 | 7035030 |
| failure to induce delayed-type hypersensitivity to mycobacterium leprae in long-term treated lepromatous leprosy patients. | lepromatous leprosy (ll) patients whose bacillary load has decreased to almost undetectable levels by long-term chemotherapy failed to develop delayed-type hypersensitivity (dth) to mycobacterium leprae antigen following immunization with killed armadillo-derived m. leprae. when these ll patients were immunization with killed armadillo-derived m. leprae. when these ll patients were immunized with killed m. leprae in a mixture with live bcg, only dth to purified protein derivative (ppd) was induc ... | 1981 | 7035031 |
| [results of bacilloscopy practiced on 360 leprosy patients, treated for over 5 years by sulfone monotherapy and examined at bamako (mali)]. | 1981 | 6805233 | |
| [clinical and paraclinical aspects of secondary drug resistance to 4-4' diaminodiphenylsulfone in a population of leprosy patients in bamako, republic of mali]. | 1981 | 6805234 | |
| uptake of 3,4-dihydroxy[3h]phenylalanine by mycobacterium leprae isolated from frozen (-80 degrees c) armadillo tissue. | mycobacterium leprae separated from armadillo tissues stored at -80 degrees c is similar to that from human sources in its ability to take up 3h-labelled 3,4-dihydroxyphenylalanine (dopa). several inhibitors were studied which showed complete or partial inhibition of [3h]dopa uptake. these findings suggest that m. leprae isolated from frozen tissue possesses an active uptake system for [3h]dopa. | 1981 | 6806435 |
| typical or atypical mycobacteria? | 1981 | 6801836 | |
| immunogenetics of susceptibility to leprosy, tuberculosis, and leishmaniasis. an epidemiological perspective. | the literature on the genetic regulation of susceptibility in leprosy, tuberculosis, amd leishmaniasis is critically reviewed. of the three groups of diseases, leprosy has received the most attention from the standpoint of human genetics. there is now evidence that genetic factors, some of them hla-linked, play a role in tuberculoid leprosy. however, the evidence leaves considerable room for environmental determinants in addition to genetic background. several twin studies of tuberculosis have f ... | 1981 | 6804402 |
| bcg, corynebacterium parvum or mycobacterium leprae added to cultures of bcg-primed mouse spleen cells cause an enhanced primary antibody response in vitro. | a few weeks after mice were injected i.v. with 10(8) live mycobacterium bovis, bcg, the antibody response of their spleen cells to srbc in vitro was comparable with the response of cells from untreated mice. addition of bcg organisms to the culture vessels resulted in enhanced antibody-forming cell (afc) responses by the primed cells but not by the cells from the untreated mice. no evidence was found for a direct stimulation of b cells and cell depletion experiments suggested macrophages were di ... | 1981 | 7007221 |
| attempt to induce immune-tolerance to m. leprae in mice. | 1981 | 7012440 | |
| pathologic changes in striated muscles in leprosy. | eighteen muscle biopsies from male adult patients of lepromatous and borderline lepromatous leprosy were studied. bi in the biopsies ranged from 1 + to 3+. there was conspicuous absence of granuloma except for a collection of foamy histiocytes in intermysial region and on two occasions in the intermysial nerve endings in ll patients. at places solid staining bacilli were seen in normal looking muscles. none of the biopsies showed loss of muscle striations, fatty change, sarcolemmal changes, fibr ... | 1981 | 7012441 |
| bcg induced immunity to mycobacterium leprae in mice. | one to three bcg vaccinations were given to various groups of mice--25 to 2 days preceding challenge with myco. leprae. harvesting of myco. leprae was done every month upto a period of 7 months. lymph node enlargement was taken as an indicator of successful vaccination. an increasing degree of protection was noted in bcg immunised mice as observed by a reduced number of bacilli harvested. protection afforded was proportional to the number of doses of bcg given. | 1981 | 7012442 |
| towards a vaccine against leprosy. | 1981 | 7012444 | |
| does the suppression of the immune response in pre-clinical lepromatous leprosy affect both cell-mediated and humoral responses in mycobacterium leprae antigens? | 1981 | 7017316 | |
| activity of four clofazimine analogues against mycobacterium leprae. | 1981 | 7017318 | |
| the mononuclear cell series in leprosy: an ultrastructural report. | 1981 | 7017319 | |
| selective loss of mycobacterium leprae responsiveness of circulating lymphocytes in primary neuritic leprosy. | 1981 | 7017320 | |
| a claim for a mycobacterium leprae specific antigen. | 1981 | 6788723 | |
| permeability of mycobacterium leprae to dapsone: alteration by purification procedures. | permeability of mycobacterium leprae to dapsone in vitro was determined by the ability of the drug to inhibit o-diphenoloxidase of the bacilli. dapsone showed little effect on the enzyme activity of the intact organisms. when the m. leprae preparations were washed with trypsin, naoh, or acetone and ether, dds penetrated the bacillus to inhibit its o-diphenoloxidase. the method might be useful in studying the utilization of added metabolites by purified m. leprae suspensions. | 1981 | 6789004 |
| adenosine triphosphate content in mycobacterium leprae. a brief communication. | 1981 | 7019109 | |
| the 1980 journal--a perspective in leprosy. | 1981 | 7019112 | |
| [t and b lymphoid subpopulations in patients with leprosy]. | 1981 | 7047979 | |
| isolation and identification of mycolic acids in mycobacterium leprae and mycobacterium lepraemurium. | mycolic acids with a characteristic structure were isolated by high performance-liquid-chromatography (hplc) and mass-spectrometry from a foot pad of a nude mouse inoculated with mycobacterium leprae. mycolic acids with the same structure were also obtained from mycobacteria collected from the liver of an armadillo with experimental leprosy. mycolic acids were isolated from mycobacterium lepraemurium grown both in vivo and in vitro and these mycolic acids had different structures from those of m ... | 1981 | 7042604 |
| the problem of dapsone-resistant leprosy. | 1981 | 7042605 | |
| dapsone-resistant leprosy-the thelep approach. | 1981 | 7042606 | |
| primary dapsone-resistant leprosy in cebu, philippines. | a survey of the prevalence of primary dapsone-resistant leprosy in cebu, philippines, has yielded an estimate of 3.6 per 100. fifty-three of 55 patients proved to have m. leprae fully susceptible to dapsone. the organisms of two patients multiplied in mice administered the minimal effective dose of dapsone; and those of one of these patients also multiplied in mice administered dapsone in a 10-fold larger dose. | 1981 | 7042607 |
| in vitro stimulation of human lymphocytes with mycobacterial antigens. | 1981 | 7042608 | |
| mycobacterium leprae and the host response. | 1981 | 7040872 | |
| the lymphocyte transformation test in leprosy with special reference to its use in epidemiology. | 1981 | 7040878 | |
| in vitro lymphocyte stimulation using a purified antigen of mycobacterium leprae and tuberculin ppd. | 1981 | 7040879 | |
| subclinical infection in leprosy--its detection and control by fluorescent leprosy antibody absorption (fla-abs) test. | 1981 | 7040880 | |
| radioimmunoassay and other serologic tests and their application in epidemiological work. | 1981 | 7040881 | |
| leprosy--the source of infection and its mode of transmission. | 1981 | 7040883 | |
| occurrence of non-cultivable acid-fast bacilli in the environment and their relationship to m. leprae. | 1981 | 7040884 |