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isobolographically additive anticonvulsant activity between centella asiatica's ethyl acetate fraction and some antiepileptic drugs.to investigate interaction between orally given centella asiatica's ethyl acetate fraction (eaca) and intraperitoneally administered antiepileptic drugs (aeds), namely, phenytoin, valproate and gabapentin.200516858951
asiatic acid induces apoptosis in sk-mel-2 human melanoma cells.asiatic acid (aa) is a pentacyclic triterpene found in centella asiatica. in the present study, the mechanism of anticancer effect of aa on skin cancer was investigated. aa decreased viability and induced apoptosis in human melanoma sk-mel-2 cells in a time- and dose-dependent manner. aa also markedly increased intracellular reactive oxygen species (ros) level and enhanced the expression of bax but not bcl-2 protein in the cells. in addition, aa-induced activation of caspase-3 activity in a dose ...200515639343
cloning and expression of a farnesyl diphosphate synthase in centella asiatica (l.) urban.a cdna encoding farnesyl diphosphate synthase (fps; ec2.5.1.1/ec2.5.1.10) was isolated from centella asiacita (l.) urban, using degenerate primers based on two highly conserved domains. a full-length cdna clone was subsequently isolated by rapid amplification of cdna ends (race) pcr. the sequence of the cafps (c. asiatica farnesyl diphosphate synthase) cdna contains an open reading frame of 1029 nucleotides encoding 343 amino acids with a molecular mass of 39.6 kda. the deduced cafps amino acid ...200515879717
emerging role of centella asiatica in improving age-related neurological antioxidant status.free radicals have been hypothesized to play an important role in ageing process. there exists an imbalance between free radical production and antioxidant defense mechanism, which may lead to cell death during ageing. our study was designed to determine whether extract of centella asiatica, an antioxidant, when administered orally (300 mg/kg body weight/day) for 60 days would prevent age-related changes in antioxidant defense system, lipid peroxidation (lpo) and protein carbonyl (pco) content i ...200516026958
phenolic contents and antioxidant activity of some food and medicinal plants.to identify promising sources of antioxidants, some food and medicinal plants were studied for total phenolic contents and antioxidant activity. the leaves, bark and fruits of terminalia arjuna, terminalia bellerica, terminalia chebula and terminalia muelleri, the leaves and fruits of phyllanthus emblica, and the seeds of syzygium cumini were found to have high total phenolic contents (72.0-167.2 mg/g) and high antioxidant activity (69.6-90.6%). leaves of eucalyptusglobulus were a rich source of ...200516096138
immunomodulatory activities of centella asiatica and rhinacanthus nasutus extracts.centella asiatica (ca) and rhinacanthus nasutus (rn )have been used for treatment of various illnesses, but the mechanisms of action remain largely unknown. this study focused on the influence of ca and rn extracts on cell-mediated and humoral immune responses. in human peripheral blood mononuclear cells (pbmcs), ca (water extract) and rn (water and ethanol extracts) significantly increased proliferation and the production of il-2 and tnf-alpha. in contrast, an ethanol extract of ca inhibited hu ...200516236006
phlebotonics for venous insufficiency.chronic venous insufficiency (cvi) is a common condition caused by inadequate blood flow through the veins, usually in the lower limbs. it can result in considerable discomfort with symptoms such as pain, itchiness and tiredness in the legs. sufferers may also experience swelling and ulcers. phlebotonics are a class of drugs that are often used to treat cvi.200516034893
adjunctive periodontal treatment with centella asiatica and punica granatum extracts in supportive periodontal therapy.centella asiatica and punica granatum are medicinal plants that have been reported to promote tissue healing and modulate host responses. preliminary study revealed positive clinical effects of an innovative preparation from the two herbal extracts in the form of biodegradable chips as a subgingival adjunct to scaling and root planing. the purpose of this research was to evaluate further augmenting efficacy the combined herbal preparation may have among maintenance patients in comparison to stan ...200516022023
[topical chemotherapy for the treatment of burns].a burn is a tissue lesion which provokes different alterations that vary from topical erythema to total destruction of the structures affected. a burn always produces an alteration in the skin, a lesion in the corneal strata is sufficient to cause the skin to lose its capacity to act as a barrier. the objective the treatment for a burn has is to produce epithelization as soon as possible in order to prevent infection and to reduce functional and esthetic aftereffects. infection is the main cause ...200515981974
cloning of a cdna probably encoding oxidosqualene cyclase associated with asiaticoside biosynthesis from centella asiatica (l.) urban.a homology-based pcr method was used to clone a cdna encoding oxidosqualene cyclase from centella asiatica, which produces a large quantity of triterpene saponins such as asiaticoside and madecassoside. sequence analysis of one clone found sequences related to beta-amyrin synthase. an open reading frame in the full-length clone was named cabas (centella asiatica putative beta-amyrin synthase). on the basis of amino acid sequence, cabas appears to be an enzyme (beta-amyrin synthase) that synthesi ...200515834571
hepatotoxicity associated with the ingestion of centella asiatica.hepatotoxicity due to herbal remedies is being increasingly recognized. centella asiatica (centella asiatica linn urban) is commercialized for multiple conditions. its active principles are pentacyclic triterpenic saponosides (asiaticoside, madecassoside).200515801887
preliminary immunomodulatory activities of methanol extracts of eclipta alba and centella asiatica.an attempt has been made to assess the immunomodulatory activity of methanol extracts of whole plant of e. alba (1.6% wedelolactone) and c. asiatica (0.18% of asiaticoside) at five dose levels (dose-response relationship) ranging from 100 to 500 mg/kg body wt. using carbon clearance, antibody titer and cyclophosphamide immunosuppression parameters. in the case of e. alba, the phagocytic index and antibody titer increased significantly and the f ratios of the phagocytic index and wbc count were a ...200415185851
centella asiatica triterpenic fraction (cattf) reduces the number of circulating endothelial cells in subjects with post phlebitic syndrome.here we report a study performed in order to assess the number of circulating endothelial cells (ec) in normal subjects and in patients with postphlebitic syndrome (pps), and the effect of treatment with centella asiatica triterpenic fraction (cattf), a drug which has been demonstrated to be effective in promoting wound healing in vivo. ec counts were determined by means of differential centrifugation and phase contrast microscopy. patients with pps showed an increased number of circulating ec i ...20041743599
the healing effects of centella extract and asiaticoside on acetic acid induced gastric ulcers in rats.in this study, the healing effects of centella asiatica water extract (ce) and asiaticoside (ac), an active constituent of ce, on acetic acid induced gastric ulcers (kissing ulcers) in rats were examined. ce was prepared from centella asiatica dry plant and the concentration of ac in ce was quantitatively determined with the use of high performance liquid chromatography analysis. different concentrations of ce and ac were orally administered to rats with kissing ulcers. they were found to reduce ...200414987949
inhibitory effects of centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats.in this study, the effects of centella asiatica water extract (ce) and its active constituent, asiaticoside (ac), on the expression and activity of inducible nitric oxide synthase (inos) during gastric ulcer healing in rats were investigated. ce was prepared from centella asiatica dry plant and the concentration of ac in ce was quantitatively determined with the use of high performance liquid chromatography analysis. different concentrations of ce (0.10 g/kg and 0.25 g/kg) and ac (5 mg/kg and 10 ...200415643549
dermal fibroblast-associated gene induction by asiaticoside shown in vitro by dna microarray analysis.asiaticoside, isolated from centella asiatica, promotes fibroblast proliferation and extracellular matrix (ecm) synthesis in wound healing. the precise mechanism, however, in molecular and gene expression levels is still unclear.200415377342
stimulation of asiaticoside accumulation in the whole plant cultures of centella asiatica (l.) urban by elicitors.the effects of a number of different elicitors on asiaticoside production in whole plant cultures of centella asiatica were studied, including yeast extract, cdcl(2), cucl(2) and methyl jasmonate (mj). only mj and yeast extract stimulated asiaticoside production--1.53 and 1.41-fold, respectively. maximum asiaticoside production was achieved following treatment with 0.1 mm mj (116.8 mg/l). the highest asiaticoside production (342.72 mg/l) was obtained after 36 days of elicitation in cultures trea ...200415316748
total phenolics and antioxidant activities of fenugreek, green tea, black tea, grape seed, ginger, rosemary, gotu kola, and ginkgo extracts, vitamin e, and tert-butylhydroquinone.the total phenolics and antioxidant activities of fenugreek, green tea, black tea, grape seed, ginger, rosemary, gotu kola, and ginkgo extracts, vitamin e, and tert-butylhydroquinone, were determined. grape seed and green tea were analyzed for their phenolic constituents using high-performance liquid chromatography. the total phenolics of the plant extracts, determined by the folin-ciocalteu method, ranged from 24.8 to 92.5 mg of chlorogenic acid equivalent/g dry material. the antioxidant activi ...200415291494
[effect of total glucosides of centella asiatica on antagonizing liver fibrosis induced by dimethylnitrosamine in rats].to investigate the anti-liver fibrosis effect of total glucosides of centella asiatica (gca) in experimental rats.200415366600
asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts.asiaticoside, isolated from centella asiatica, promotes fibroblast proliferation and extracullar matrix synthesis in wound healing. the precise mechanism, however, in molecular and gene expression levels still remains partially understood. using cdna microarray technology, the alternation of genes expression profiles was determined in a human dermal fibroblast in vitro in the presence of asiaticoside (30 microg/ml). fifty-four genes, with known functions for cell proliferation, cell-cycle progre ...200415533060
protective effect of centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats.increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. in this study the cardio protective effect of centella asiatica on myocardial marker enzymes and antioxidant enzymes in adriamycin induced cardiomyopathy was investigated in rats. the rats administered with adriamycin (2.5 mg/kg body wt, i.p) caused myocardial damage that was manifested by the ele ...200415556170
[asiaticoside inducing apoptosis of tumor cells and enhancing anti-tumor activity of vincristine].asiaticoside (ats), a triterpene extracted from centella asiatica (l.) urban, a traditional chinese herb, possesses good wound healing activities because of its stimulative effect on collagen synthesis. recently, the anti-tumor effect of asiaticiside has been reported. this study was to examine the induction of apoptosis in cancer cells, and the enhancement of vincristine (vcr) cytotoxicity by asiaticoside.200415601545
inhibitory effects of centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of f344 rats.effects of the water extract of centella asiatica linn. on formation of azoxymethane (aom)-induced aberrant crypt foci (acf) and intestinal tumorigenesis in male f344 rats were investigated. treatment with the extract significantly decreased the number of larger acf (with four or more crypts per focus) in the large intestine in the early stage, while the number of methylated dna adducts was not decreased compared with that in the aom-treated group. in the post-initiation stage, the extract signi ...200415500935
thai medicinal plants modulate nitric oxide and tumor necrosis factor-alpha in j774.2 mouse macrophages.centella asiatica (ca) and rhinacanthus nasutus (rn) are thai medicinal plants traditionally used to treat a variety of disorders including inflammatory conditions and infections. nitric oxide (no) produced from activated macrophages plays a role in both inflammatory and anti-inflammatory processes. this study examined whether ca and rn modulate the production of no and tumour necrosis factor-alpha (tnf-alpha) by j774.2 mouse macrophages. expression of the inducible nitric oxide synthase (inos) ...200415507334
from medical herbalism to phytotherapy in dermatology: back to the future.plant-based therapeutic preparations are cyclically returning to complement dermatologic therapy. they serve as therapeutic alternatives, safer choices, or in some cases, as the only effective treatment. folk medicine tradition provides different indicators for use than the medical disease model. advantages of multiple synergistic components of crude extracts are discussed, as well as herbs already used in dermatology. bitter digestive stimulants are used for vitiligo. bioflavinoids from buckwhe ...200312919112
plant medicines of indian origin for wound healing activity: a review.research on wound healing drugs is a developing area in modern biomedical sciences. scientists who are trying to develop newer drugs from natural resources are looking toward the ayurveda, the indian traditional system of medicine. several drugs of plant, mineral, and animal origin are described in the ayurveda for their wound healing properties under the term vranaropaka. most of these drugs are derived from plant origin. some of these plants have been screened scientifically for the evaluation ...200315866825
gene expression changes in the human fibroblast induced by centella asiatica triterpenoids.the molecular pathways underlying the diverse biological activity of the triterpeniod compounds isolated from the tropical medicinal plant centella asiatica were studied with gene microarrays and real-time reverse transcription polymerase chain reaction (real-time rt-pcr) to quantify the expression of 1053 human genes in human fibroblasts. fibroblast cells grown in culture were used as a model system to evaluate the stimulation of wound healing by titrated extract from centella asiatica (teca) a ...200314531023
effect of centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of alzheimer's disease in rats.1. centella asiatica, an indian medicinal plant, has been described as possessing central nervous system activity, such as improving intelligence. in addition, we have demonstrated that c. asiatica has cognitive-enhancing and anti-oxidant properties in normal rats. oxidative stress or an impaired endogenous anti-oxidant mechanism is an important factor that has been implicated in alzheimer's disease (ad) and cognitive deficits seen in the elderly. 2. intracerebroventricular (i.c.v.) streptozotoc ...200312859423
effect of centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats.cognitive impairment in epileptics may be a consequence of the epileptogenic process as well as antiepileptic medication. thus, there is a need for drugs, which can suppress epileptogenesis as well as prevent cognitive impairment. in the present study, the effect of aqueous extract of centella asiatica (ca) (100 and 300 mg/kg), an indian medicinal plant known to possess antiepileptic, cognitive-enhancing and antioxidant property, was evaluated on the course of kindling development, kindling-indu ...200312543222
nutritional support for wound healing.healing of wounds, whether from accidental injury or surgical intervention, involves the activity of an intricate network of blood cells, tissue types, cytokines, and growth factors. this results in increased cellular activity, which causes an intensified metabolic demand for nutrients. nutritional deficiencies can impede wound healing, and several nutritional factors required for wound repair may improve healing time and wound outcome. vitamin a is required for epithelial and bone formation, ce ...200314653765
structure and potential immunological activity of a pectin from centella asiatica (l.) urban.s3a was a rg-i pectin isolated from centella asiatica that contained rha, ara, gal, glc and gala in molar ratio of 1.0:0.6:1.5:0.2:1.1 and had been found to have a backbone composed mainly of the disaccharide repeat unit, -->4)-alpha-d-galpa-(1-->2)-alpha-l-rhap-(1-->. based on methylation analysis, naio4 oxidation, partial acid hydrolysis and lithium-treatment, the structural features were elucidated. side chains of s3a were predominantly linked to o-4 of 1,2,4-linked alpha-l-rhap. the side cha ...200314572724
an improved hplc method for quantitative determination of six triterpenes in centella asiatica extracts and commercial products.an improved hplc qualitative and quantitative method of six triterpenes (asiaticoside, madecassoside, asiatic acid, madecassic acid, terminolic acid, and asiaticoside-b) in centella asiatica (raw plant material and preparations) is described in this paper. after 50 minutes the six active triterpenes were separated and detected in the methanolic extract at a limit of 0.01 microg/ml. the method uses a phenomenex aqua 5mu c18 (200 a) column as the stationary phase, a gradient mobile phase of water ...200312856998
anti-oxidant activity of centella asiatica on lymphoma-bearing mice.oral treatment with 50 mg x kg(-1) day(-1) of crude methanol extract of centella asiatica for 14 days significantly increased the anti-oxidant enzymes, like superoxide dismutase (sod), catalase and glutathione peroxidase (gshpx), and anti-oxidants like glutathione (gsh) and ascorbic acid decreased in lymphoma-bearing mice.200312837356
[effect of total triterpenes from centella asiatica on the depression behavior and concentration of amino acid in forced swimming mice].to evaluate the antidepressant activity of total triterpenes from centella asiatica in forced swimming test.200315058206
adjunctive periodontal treatment with centella asiatica and punica granatum extracts. a preliminary study.centella asiatica and punica granatum are medicinal herbs that have been reported to promote tissue healing and modulate host responses. the purpose of this study was to investigate the effects of the combined extracts from c. asiatica and p. granatum pericarp on periodontal healing following scaling and root planing in adult periodontitis patients.200314604059
immunomodulating effects of rasayana drugs in diabetics - a clinical study.immune system plays an important role in pathogenesis of diabetes (dm). besides hypoglycaemics, rasayanas are indicated in the management of dm. in several studies the immunomodulatroy potentials of rasayanas have been proved. a clinical trial of three rasayana drugs, asparagus recemosus (ar). bacopa monnieri (bm) and centella asiatica (ca) was carried out in diabetics. in this study, diabetics were found to have significantly lower levels of serum igg, increased serum iga and comparable levels ...200222557085
an in vitro, ex vivo, and in vivo demonstration of the lipolytic effect of slimming liposomes: an unexpected alpha(2)-adrenergic antagonism.most of the slimming products already developed for cosmetic applications did not result from strategies that integrate whole lipolysis-regulating mechanisms. we thus focused our attention on a more complete integration of these mechanisms and we developed slimming liposomes (slc) containing two micro-circulation activators, i.e., esculoside and centella asiatica extracts, one phosphodiesterase inhibitor, i.e., caffeine, and one fatty acid-beta oxidation activator, i.e., l-carnitine. the validit ...200212219247
in vitro anti-hepatoma activity of fifteen natural medicines from canada.fifteen crude drugs, stellaria media cyrill. (caryophyllaceae), calendula officinalis l. (compositae), achillea millefolium l. (compositae), verbascum thapsus l. (scrophulariaceae), plantago major l. (plantaginaceae), borago officinalis l. (boraginaceae), satureja hortensis l. (labiatae), coptis groenlandica salisb. (ranunculaceae), cassia angustifolia vahl. (leguminosae), origanum majorana l. (labiatae), centella asiatica l. (umbelliferae), caulophyllum thalictroides mich. (berberidaceae), pice ...200212203264
effect of different extracts of centella asiatica on cognition and markers of oxidative stress in rats.centella asiatica, a plant mentioned in indian literature has been described to possess cns effects such as stimulatory-nervine tonic, rejuvenant, sedative, tranquilizer and intelligence promoting property. in the present study aqueous, methanolic and chloroform extracts of c. asiatica were investigated for their effect on cognitive functions in rats. male wistar rats of 200-250 g were used to study the effect on learning and memory by using shuttle box, step through, step down and elevated plus ...200211801389
radioprotection of swiss albino mouse by centella asiatica extract.centella asiatica, has a considerable reputation in the indian system of medicine. it is a rasayan (general tonic), brain tonic, improves memory and strengthens the cns. in view of its multifarious uses, the plant extract was tested for its radioprotective properties. a sublethal dose of co 60 gamma radiation, i.e. 8 gy was selected for the purpose. animals were divided into two groups. the whole bodies were irradiated with co 60 gamma radiation externally, with and without drug extract. the dru ...200212458490
evaluation of the cytotoxicity, mutagenicity and antimutagenicity of emerging edible plants.this study evaluates the toxic, mutagenic and antimutagenic effects of emerging edible plants that are consumed as new leafy vegetables in taiwan. among eight plant extracts, only the extracts of sol (solanum nigrum l.) showed cytotoxicity to salmonella typhimurium ta100 in the absence of s9 mix. the toxicity of extracts from different parts of the sol plant, such as leaf and stem, immature fruit and mature fruit, towards s. typhimurium ta100 and human lymphocytes was also assayed. the immature ...200111527563
total triterpenic fraction of centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy.total triterpenic fraction of centella asiatica (ttfca) is effective in improving venous wall alterations in chronic venous hypertension and in protecting the venous endothelium. ttfca is active on connective tissue modulation, improves the synthesis of collagen and other tissue proteins by modulating the action of fibroblasts in the vein wall, and stimulates collagen remodeling in and around the venous wall. this is due to the modulating action of ttfca on fibroblasts as shown by experiments on ...200111666128
effect of centella asiatica linn on physical and chemical factors induced gastric ulceration and secretion in rats.centella asiatica is commonly mentioned as a rasayana in ayurveda, an ancient system of indian medicine for various ailments including abdominal disorders. rasayanas have been advocated for use in rejuvenation therapy. the present study was conducted to evaluate the possible anti-ulcerogenic activity of fresh juice of c. asiatica (caj) against ethanol-, aspirin-, cold-restraint stress- and pyloric ligation induced gastric ulcers in rats. the drug given orally in doses of 200 and 600 mg/kg twice ...200111480209
protection against radiation-induced conditioned taste aversion by centella asiatica.radiations are known to cause behavioural perturbations like conditioned taste aversion (cta), performance decrement, learning, etc., even at very low doses. the manifestation of radiation-induced behavioural degradation has not been understood well and requires further studies. therefore, the effects of low-dose whole-body 60co gamma-irradiation in male rats were studied in terms of body weight and cta learning. for cta, the consumption of saccharin solution was considered as a parameter. to pr ...200111399290
hemorrhoids and varicose veins: a review of treatment options.hemorrhoids and varicose veins are common conditions seen by general practitioners. both conditions have several treatment modalities for the physician to choose from. varicose veins are treated with mechanical compression stockings. there are several over-the-counter topical agents available for hemorrhoids. conservative therapies for both conditions include diet, lifestyle changes, and hydrotherapy which require a high degree of patient compliance to be effective. when conservative hemorrhoid ...200111302778
standardisation and quality evaluation of centella asiatica linn.centella asiatica linn. is a well-known medicinal herb used in various types of diseases, it was noticed that the herb is being heavily adulterated with the cheaper substances. a critical stud of the authentic and maker samples (available in powder for) s carried out to study current status of the drug in the local market. powder analysis of the market samples shoes fragments of sclerenchymatous net, which is a characteristic feature of some umbelliferous fruits. occurrence of prismatic crystals ...200122557022
effects of the total triterpenic fraction of centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial.the aim of this study was to demonstrate whether total triterpenic fraction of centella asiatica (ttfca), was effective in improving the microcirculation in venous hypertension and microangiopathy. forty patients with severe venous hypertension, ankle swelling, lipodermatosclerosis were included. after informed consent, patients were randomized into a treatment and a placebo group: those in the treatment group received ttfca (tablets, 60 mg, twice daily for 8 weeks). the two groups of subjects w ...200111666117
medicinal foodstuffs. xxvii. saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins b, c, and d, from centella asiatica cultivated in sri lanka.ursane- and oleanane-type triterpene oligoglycosides, centellasaponins b, c, and d, were isolated from the aerial parts of centella asiatica (l.) urban cultivated in sri lanka together with madecassoside, asiaticoside, asiaticoside b, and sceffoleoside a. the chemical structures of centellasaponins b, c, and d were determined on the basis of chemical and physicochemical evidence to be madecassic acid 28-o-beta-d-glucopyranosyl(1-->6)-beta-d-glucopyranoside, madasiatic acid 28-o-alpha-l-rhamnopyr ...200111605675
in vitro keratinocyte antiproliferant effect of centella asiatica extract and triterpenoid saponins.psoriasis is a hyperproliferative skin disorder estimated to be present in 1-3% of most populations. conventional therapy using corticosteroids, vitamin d analogs and cytotoxic agents eg psoralens is associated with low success rate and many side effects. traditional plant remedies may provide leads for new treatments. a rapid-throughput, in vitro bioassay has been utilised to examine plants for inhibitory effects on the growth of svk-14 keratinocytes. centella asiatica, a reputed anti-psoriatic ...200111417919
increase in echogenicity of echolucent carotid plaques after treatment with total triterpenic fraction of centella asiatica: a prospective, placebo-controlled, randomized trial.the aim of this study was to evaluate whether total triterpenic fraction of centella asiatica (ttfca), was effective in modulating collagen production over 12 months, by producing an increase in echogenicity in echolucent carotid plaques. part i was a pilot study aimed at evaluating the effects of ttfca on different types of plaques. part ii was a prospective, randomized, placebo-controlled trial aimed at evaluating the effects of ttfca on hypoechoic-echolucent plaques. the sonographic examinati ...200111666118
treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial.the variation of capillary filtration rate (cfr), ankle circumference (ac), and ankle edema (ae) was evaluated in three groups of patients with venous hypertension (ambulatory venous pressure >42 mm hg) and in a group of normal subjects before and after treatment for 4 weeks with total triterpenic fraction of centella asiatica (ttfca), a venoactive drug acting on the microcirculation and on capillary permeability. group a (20 patients)was treated with ttfca 60 mg thrice daily, group b (20 patien ...200111666125
[effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency].the aim of this comparative clinical study was to evaluate the efficacy of the association of alphatocopherol, rutin, melilotus officinalis, and centella asiatica with oral administration in patients with chronic venous insufficiency.200111292962
microcirculatory effects of total triterpenic fraction of centella asiatica in chronic venous hypertension: measurement by laser doppler, tcpo2-co2, and leg volumetry.the aim of this prospective, randomized study was to demonstrate whether an oral preparation of ttfca was effective in improving the microcirculation and edema (leg volume) in venous microangiopathy. forty patients with venous hypertension were included. treatment was prescribed for 6 weeks (tablets, 60 mg twice daily). patients were randomized into a treatment and a placebo group. there were 20 patients in each group. in the treatment group the mean age was 42 (sd 7; m:f = 10:10); in the placeb ...200111666123
flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of centella asiatica.the aim of this study was the evaluation of microcirculatory alterations associated with edema in passengers travelling for more than 3 hours and the study of the effects of ttfca (total triterpenic fraction of centella asiatica) on the development of microcirculation alterations and edema, in a prospective, randomized study. laser doppler flowmetry (ldf), transcutaneous po2 and pco2, rate of ankle swelling (ras) were used. subjects were randomized after informed consent into two groups: one con ...200111666121
treatment of diabetic microangiopathy and edema with total triterpenic fraction of centella asiatica: a prospective, placebo-controlled randomized study.the aim of this study was to demonstrate in a prospective, placebo-controlled, randomized study, whether total triterpenic fraction of centella asiatica (ttfca) is effective in improving the microcirculation in diabetic microangiopathy and neuropathy, patients with severe diabetic microangiopathy, neuropathy, and edema; patients with microangiopathy without neuropathy; and healthy subjects were included. microangiopathy was defined by laser doppler and capillary filtration (rate on ankle swellin ...200111666119
development of a novel dosage form for intramuscular injection of titrated extract of centella asiatica in a mixed micellar system.titrated extract of centella asiatica (teca), a drug used in treating systemic scleroderma, is poorly water-soluble. a conventional dosage form for the intramuscular injection of teca, propylene glycol (pg)-based teca solution, causes severe pain after intramuscular injection. to improve the solubility of teca and reduce pain after injection, mixed micellar systems composed of 10% surfactant mixture (tween 20 and tween 85) and 90% phosphate-buffered saline, ph 7.0 (pbs) were prepared. as the rat ...200111376976
total triterpenic fraction of centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model.a single-blind, placebo-controlled, randomized study was performed on the effects of different doses of the total triterpenic fraction of centella asiatica (ttfca) in patients with venous hypertensive microangiopathy. a combined microcirculatory model that considers laser doppler flowmetry (ldf) and transcutaneous oxygen (po2), transcutaneous carbon dioxide tension (pco2) measurements was combined with the symptom evaluation. ldf tests included the baseline resting flow, the venoarteriolar refle ...200111666126
evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of centella asiatica: a clinical prospective randomized trial with a microcirculatory model.fifty patients with diabetic microangiopathy were studied by laser doppler flowmetry (measuring skin blood flow at rest) (rf) and the venoarteriolar response (var), by transcutaneous po2 and pco2 measurements, and by capillary permeability evaluation (rate of ankle swelling [ras]). thirty of these patients were treated for 6 months with total triterpenic fraction of centella asiatica (ttfca) (60 mg twice daily), a drug active on microcirculation and capillary permeability. a control group of ten ...200111666124
modification of the echogenicity of femoral plaques after treatment with total triterpenic fraction of centella asiatica: a prospective, randomized, placebo-controlled trial.the aim of this study was to evaluate whether ttfca (total triterpenic fraction of centella asiatica), was effective, by modulating collagen production, in a period of 12 months, increasing the echogenicity of echolucent plaques at the femoral bifurcation. hypoechoic atherosclerotic plaques have been found to be associated with an increased evidence of cerebrovascular events. in this type of plaques stromal composition is limited as the collagen component is generally very low; the plaque compos ...200111666127
topical formulation of a new plant extract complex with refirming properties. clinical and non-invasive evaluation in a double-blind trial.we tested an otc formulation versus placebo in a double-blind trial to evaluate its ability to improve elasticity and firmness of the skin. the clinical non-invasive evaluation in 20 volunteers shows: 1. no adverse reactions such as itching or irritation 2. efficacy and cosmetic acceptibility of the test cream 3. an increase in electrical capacitance (moisture content) even though without statistical significance. this result is not surprising because the patients had healthy skin and were relat ...200018503475
chemical, pharmacological and clinical profile of the east asian medical plant centella asiatica.centella asiatica is a medicinal plant that has been in use since prehistoric times. its active constituents include pentacyclic triterpene derivatives. studies have been conducted in particular to investigate the madecassosides and asiaticosides. in common with most traditional phytotherapeutic agents, centella asiatica is used in folk medicine to treat a wide range of indications. in contrast to other medicinal plants, however, centella asiatica has been subjected to quite extensive experiment ...200011081995
characterization of an ursane triterpenoid from centella asiatica with growth inhibitory activity against spilarctia obliqua.a new triterpenoid glycoside 3-o-[a-l-arabinopyranosyl] 2 a, 3 ß , 6 ß , 23-a tetrahydroxyurs-12-ene-28-oic acid ( 1 ) accompanied by 6ß-hydroxyasiatic acid and asiatic acid were isolated from centella asiatica . the structure of 1 was established by physicochemical data. compound 1 exhibited dose-dependent growth inhibitory activity against larvae of spilarctia obliqua but was not as active as azadirachtin.200021214472
individuals at risk of coronary heart disease (chd), its prevention and management by an indigenous compound.a variety of rist factors have been suspected for causing the coronary heart disease. 406 cases of both sex groups with age range of 35 to 55 years were selected from three distinct localities of varanasi city. individuals who reported single or more risk factors of chd were isolated from the population of the particular areas. after a detailed preliminary screening of the subjects various physical, physiological, psychological and biochemical measurements were carried out. other basis of initia ...200022556998
creams for preventing stretch marks in pregnancy.many women develop stretch marks (striae gravidarum) during pregnancy. a number of creams have been used to remove these stretch marks.200010796111
[resources distribution and pharamacognostic identification of centella asiatica (l.) urban produced in china].to investigate the resources distribution and morphological histology of centella asiatica distributed in china, and offer evidences for exploiting the plant resources and drafting the quality standards.200012512431
a double-blind, placebo-controlled study on the effects of gotu kola (centella asiatica) on acoustic startle response in healthy subjects.investigations of the pharmacologic profile of medicinal plants have revealed that a number of plants with purported anxiolytic activity bind to cholecystokinin (cck) receptors. this finding is intriguing in view of the proposed involvement of cck in the pathophysiology of fear and anxiety. this double-blind, placebo-controlled study was undertaken to evaluate the anxiolytic activity of gotu kola (centella asiatica) in healthy subjects. gotu kola has been used for centuries in ayurvedic and trad ...200011106141
effects of centella asiatica on ethanol induced gastric mucosal lesions in rats.centella asiatica is a herbal medicine widely used in china and india for wound healing. the aim of this study was to examine its effects on the prevention of ethanol induced gastric lesions in rats. gastric transmucosal potential difference (pd) was reduced by the application of 50% ethanol in the gastric ex-vivo chamber model and centella extract (ce) accelerated its recovery. oral administration of ce (0.05 g/kg, 0.25 g/kg and 0.50 g/kg) before ethanol administration significantly inhibited g ...200011104366
asiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxicity.asiatic acid, a triterpene of centella asiatica (l.) urban (umbelliferae), has been patented as a treatment for dementia and an enhancer of cognition by the hoechst aktiengesellschaft (ep 0 383 171 a2). we modified the chemical structure of asiatic acid and obtained 36 derivatives of asiatic acid in an attempt to prepare neuroprotective compounds that were more efficacious than asiatic acid itself. the neuroprotective activities of these derivatives were evaluated using primary cultures of rat c ...200011758977
anti-herpes simplex virus activities of crude water extracts of thai medicinal plants.a number of thai medicinal plants, recommended as remedies for herpesvirus infection and have been used in primary health care were investigated for their intracellular activities against herpes simplex viruses (hsv). centella asiatica l., maclura cochinchinensis cornor, and mangifera indica l. contained both anti-hsv-1 and -2 activities, as determined by plaque inhibition assay. an inhibition of the production of infectious hsv-2 virions from infected vero cells could also be demonstrated. comb ...200010715843
electrospray characterization of selected medicinal plant extracts.extracts of selected medicinal plants were examined by electrospray mass spectrometry (esi-ms). this technique allowed identification of the main components of each extract, thereby providing a typical finger-print of the examined plants. more specifically, anthocyanins (vaccinium myrtillus), isoflavones (glycine max, soybean), flavonol-glycosides and terpenes (ginkgo biloba), triterpenes (centella asiatica), caffeoyl-quinic acids (cynara scolymus, artichoke), ginsenosides (panax ginseng), catec ...200010898155
the effect of tetrandrine and extracts of centella asiatica on acute radiation dermatitis in rats.radiation injury to the skin is one of the major limiting factors in radiotherapy. we designed this study using sprague-dawley rats to evaluate the reduction in skin injury achieved using natural products from plant extracts as protection. the acute skin reaction in tetrandrine- and madecassol-treated animals appeared earlier, but was significantly less severe, than in the control group. the peak skin reactions in the tetrandrine group were less serious than those of the control group at three d ...199910443466
in vitro and in vivo wound healing activity of asiaticoside isolated from centella asiatica.the activity of asiaticoside, isolated from centella asiatica, has been studied in normal as well as delayed-type wound healing. in guinea pig punch wounds topical applications of 0.2% solution of asiaticoside produced 56% increase in hydroxyproline, 57% increase in tensile strength, increased collagen content and better epithelisation. in streptozotocin diabetic rats, where healing is delayed, topical application of 0.4% solution of asiaticoside over punch wounds increased hydroxyproline conten ...199910350364
triterpenes from centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds.titrated extract from centella asiatica (teca) is a drug which has been used for many years in europe for the treatment of wound healing defects. it is a reconstituted mixture of 3 triterpenes extracted from the plant, asiatic acid, madecassic acid and asiaticoside. in this report, we studied the effects of teca and its separated components in the wound chamber model described by schilling et al. stainless steel wound chambers were surgically inserted under the skin of rats and received serial i ...199910356407
asiaticoside-induced elevation of antioxidant levels in healing wounds.asiaticoside derived from the plant centella asiatica is known to possess good wound healing activity. enhanced healing activity has been attributed to increased collagen formation and angiogenesis. since antioxidants have been reported to play a significant role in the wound healing process we studied the effect of asiaticoside on the levels of certain antioxidants in the wound so as to explore the possible involvement of such a mechanism in the asiaticoside induced wound healing. asiaticoside ...199910189951
effect of different drying methods on concentrations of several phytochemicals in herbal preparation of 8 medicinal plants leaves.the effect of oven drying at 50ᵒc ± 1ᵒc for 9 hour, 70ᵒc ± 1ᵒc for 5 hour and freeze drying on retention of chlorophyll, riboflavin, niacin, ascorbic acid and carotenoids in herbal preparation consisting of 8 medicinal plants was evaluated. the medicinal plants selected were leaves of apium graveolens (saderi), averrhoa bilimbi (belimbing buluh), centella asiatica (pegaga), mentha arvensis (pudina), psidium guajava (jambu batu), sauropus androgynous (cekor manis), solanum nigrum (terung meranti) ...199922692357
extraction and analysis of cosmetic active ingredients from an anti-cellulitis transdermal delivery system by high-performance liquid chromatography.a new transdermal delivery system that controls cellulitis is evaluated using reversed-phase high-performance liquid chromatography coupled with photodiode array detection. an extraction procedure and the validation of the analytical method to assay the active excipients from the centella asiatica plant (asiaticoside, madacessic acid, and asiatic acid) are described. excellent results ae obtained in terms of linearity, accuracy, and specificity of the analytical method.199910065405
evaluation of topical formulations of aqueous extract of centella asiatica on open wounds in rats.formulations (ointment, cream and gel) of aqueous extract of c. asiatica, when applied topically, thrice daily for 24 days on the open wounds in rats increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in collagen content and tensile strength. the treated wounds epithelialised faster and the rate of wound contraction was higher as compared to control wounds. the process of healing was better with gel formulation when compared to other two formulati ...19989731470
in vitro evaluation of inhibitory nature of extracts of 18-plant species of chhindwara against 3-keratinophilic fungi.effect of extract of 18 plant species, viz., acorus calamus, adhatoda vasica, amomum subulatum, andrographis paniculata, boerhaavia diffusa, cassia occidentalis, centella asiatica, cymbopogon citratus, hemidesmus indicus, hyptis suaveolens, malvestrum sp., passiflora edulis, pergularia daemia, peristrophe bicalyculata, shuteria hirsuta, solanum nigrum, tecoma stans, and verbascum chinense on the growth of microsporum gypseum, chrysosporium tropicum and trichophyton terrestre was evaluated and di ...199710386016
effects of centella asiatica extract on dermal wound healing in rats.effects of oral and topical administration of an alcoholic extract of c. asiatica on rat dermal wound healing was studied. the extract increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in dna, protein and collagen content of granulation tissues. quicker and better maturation and crosslinking of collagen was observed in the extract-treated rats, as indicated by the high stability of acid-soluble collagen and increase in aldehyde content and tensil ...19969246912
quantitative determination of triterpenes in extracts and phytopreparations of centella asiatica (l.) urban.a new method for separation and quantitative determination of triterpenes in centella asiatica herb and its pharmaceutical preparations has been developed. separation of all pharmacologically relevant triterpenes (asiaticoside, madecassoside, asiatic- and madecassic acid) was achieved by hplc employing the reversed-phase separation system acetonitrile/water on rp18 columns at a detection wavelength of 205 nm. quantification was carried out by the method of external standard with calibration curv ...199623194862
allergic contact dermatitis from butoxyethyl nicotinic acid and centella asiatica extract. 19958706410
cytotoxic and anti-tumour properties of certain taxa of umbelliferae with special reference to centella asiatica (l.) urban.centella asiatica (l.) urban (umbelliferae) is commonly used in the ayurvedic system of medicine to treat various diseases. the present study examines the anti-tumour effect of the crude extract (ce) of centella asiatica as well as its partially purified fractions (af) from chromatographic procedures by both in vitro short and long term chemosensitivity and in vivo tumour model test systems. af dose dependently inhibited the proliferation of the transformed cell lines significantly more than did ...19958569247
in vitro experiments with centella asiatica: investigation to elucidate the effect of an indigenously prepared powder of this plant on the acid-fastness and viability of m. tuberculosis.the herb centella asiatica (linn.), found throughout india, is acclaimed to have medicinal properties and has been used in leprosy patients from very early times. it is considered that the active compound of this herb, called asiaticoside, probably acts on the waxy covering of m. leprae. the in vitro effect of an indigenously produced dry powder of centella asiatica (ca) on the acid-fastness and viability of m. tuberculosis was investigated in the present study. the results indicate that ca may ...19947983394
allergic contact dermatitis due to centella asiatica extract. 19947821029
amino acid analysis of intellan, a herbal product used in enhancing brain function.analysis of the drug "intellan" and two reputed plants i.e. centella asiatica and herpestis monniera used in the preparation of the drug reveals that glutamic and aspartic acids are present in high concentration in the drug and are also required by brain in high concentration to keep itself in higher gears. both these amino acids are used as neurotransmitters and also in stabilizing and stimulating the activities of brain, thus resulting in better performance.199416414752
[the microcirculatory activity of centella asiatica in venous insufficiency. a double-blind study].in 87 patients with chronic venous hypertensive microangiopathy the efficacy of oral fttca (centella asiatica) administered for 60 days was tested. the microcirculatory effects of two dosages (30 mg bid and 60 mg bid) versus placebo was assessed in a double blind study. the compound was well tolerated and no unwanted effects were observed. microcirculatory parameters--peri-malleolar skin flux at rest (rf) and transcutaneous po2 and pco2--improved as did the abnormally increased rf, pco2 decrease ...19947936334
pharmacognostic studies on centella asiatica (l) urban.the paper deals with pharmacognosy of centella asiatica (l.) urban, including its morphological, anatomical, chemical constituents and powder analysis. stomata are mostly anisotricytic, isotricytic and few tetracytic. sphaero-crystals of calcium oxalate are observed in palisade, spongy and ground parenchyma of leaf lamina, petiole and rhizome and absent in roots. uniseriate flagellate conical hairs present only on abaxial surface of leaf and all over the petiole. the venation is palmatous actino ...199322556625
enhancement of the attachment on microcarriers and tpa production by fibroblast cells in a serum-free medium by the addition of the extracts of centella asiatica.the addition of ethanol extracts of centella asiatica showed a remarkable enhancement of fibroblast cells attachment to cytodex beads in serum-free (sf) medium. it also improves tpa production in both batch and perfusion cultivations. the optimal concentration for sf medium was determined as 2 ppm of the extracts when using cytodex iii. in batch cultivation a high specific tpa production rate was obtained, compared to that from 5% fbs containing medium. however, a fast specific growth rate was o ...19937764663
centella asiatica (indian pennywort), an effective therapeutic but a weak sensitizer.the sensitizing capacity of centella asiatica (raw extract) and its triterpenic constituents asiaticoside, asiatic acid and madecassic acid has been studied in guinea pigs. the extract itself as well as the 3 acids were found to be very weak sensitizers. centella asiatica extract is used effectively in the treatment of keloids, leg ulcers, phlebitis, slow-healing wounds, leprosy, surgical lesions, striae distensae and cellulitis. although applied frequently to damaged skin, the risk of acquiring ...19938281778
effects of plant extract centella asiatica (linn.) on cold restraint stress ulcer in rats.extract of c. asiatica (linn.) inhibited significantly gastric ulceration induced by cold and restraint stress (crs) in charles-foster rats, antiulcer activity of plant extract was compared with famotidine (h2-antagonist) and sodium valproate (anti-epileptic). plant extract, formotidine and sodium valproate showed a dose dependent reduction of gastric ulceration. plant extract increased brain gaba level which was also dose dependent. pretreatment with bicuculline methiodide (specific gabaa-antag ...19921293014
[activity of centella asiatica in venous insufficiency].in this a review concerning ttfca, its effects on metabolism in the connective tissue of the vascular wall and on the microcirculation are presented and discussed. this compound is effective in venous insufficiency, reducing ankle edema, foot swelling, capillary filtration rate and by improving microcirculatory parameters (rf, var po2-pco2). ttfca displays a significant activity in venous hypertensive microangiopathy and its effects are dose-dependent.19921528498
allergic contact dermatitis from a cream containing centella asiatica extract. 19921387057
triterpenoids and their glycosides from the bark of schefflera octophylla.a new triterpene and its glycosides were isolated from the bark of schefflera octophylla together with asiatic acid and asiaticoside. based on spectroscopic data, especially 2dnmr, and chemical transformations the structures of the new compounds were determined as 3 alpha-hydroxy-urs-12-ene-23,28-dioic acid and 3 alpha-hydroxy-urs-12-ene-23,28-dioic acid 28-o-[alpha-l-rhamnopyranosyl (1----4)-o-beta-d-glucopyranosyl (1----6)]-beta-d-glucopyranoside. for the first time asiaticoside was isolated f ...19921367880
prophylaxis of striae gravidarum with a topical formulation. a double blind trial.synopsis a prophylactic antistriae cream (centella asiatica extract, alpha-tocopherol, and collagen-elastin hydrolisates) was assessed by a double blind trial in 80 pregnant women. in the placebo group 22 women (56%) presented striae, whereas in the treated group only 14 women (34%) developed striae in this pregnancy; this difference was significant (p < 0.05; chi(2) test). an arbitrary score was designed to assess the intensity of striae (from 0 to 3); this score was 1.42 (sd 0.5) in the treate ...199119291041
effects of centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins.the effects were studied of the total triterpenic fraction of centella asiatica on serum levels of the uronic acids and lysosomal enzymes involved in mucopolysaccharide metabolism (beta-glycuronidase, beta-n-acetylglucosaminidase, arylsulfatase) in patients with varicose veins. the basal levels of uronic acids (467.7 +/- 69.3 micrograms/ml) and of lysosomal enzymes (beta-glycuronidase 1.8 +/- 0.4 microm/min/l, beta-n-acetylglucosaminidase 23.1 +/- 0.4 microm/min/l, arysulfatase 0.078 +/- 0.003 m ...19902150405
improvement of capillary permeability in patients with venous hypertension after treatment with ttfca.the vsc (vacuum suction chamber) device, a new system to evaluate local capillary permeability, was used with laser doppler flowmetry to study variations of permeability and of the microcirculation in 10 normal subjects; in 22 patients with moderate, superficial venous hypertension; and in 12 patients with postphlebitic limbs and severe venous hypertension. all these patients had distal (ankle and foot edema) in the evening. after a first assessment these subjects were studied again after two we ...19902389834
pharmacokinetics of the total triterpenic fraction of centella asiatica after single and multiple administrations to healthy volunteers. a new assay for asiatic acid.a new hplc assay method was used to investigate the pharmacokinetics of asiatic acid after oral administration of the total triterpenic fraction of centella asiatica in single doses (30 or 60 mg) and after a 7-day treatment (30 or 60 mg twice daily). twelve healthy volunteers received each treatment following a randomized cross-over design with trials separated by a 3-week interval. the time of peak plasma concentration was not affected by dosage difference or by treatment scheme. differences in ...19902329813
capillary filtration and ankle edema in patients with venous hypertension treated with ttfca.the variation of capillary filtration rate (cfr), ankle circumference (ac), and ankle edema (ae) was evaluated in three groups of patients with venous hypertension (ambulatory venous pressure greater than 42 mmhg) and in a group of normal subjects before and after treatment for four weeks with total triterpenic fraction of centella asiatica (ttfca), a venoactive drug acting on the microcirculation and on capillary permeability. group a (20 patients) was treated with ttfca 60 mg tid; group b (20 ...19902305995
stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from centella asiatica.the drug "titrated extract from centella asiatica" (teca), used for its stimulating properties on the healing of wounds, is a mixture of 3 terpenes extracted from a tropical plant: asiatic acid (30%, w/w), madecassic acid (30%, w/w) and asiaticoside (40%, w/w). the effects of teca and its individual components were checked on human foreskin fibroblast monolayer cultures. teca increased the collagen synthesis in a dose-dependent fashion whereas a simultaneous decrease in the specific activity of ...19902354631
an experimental study of the anti-hsv-ii action of 500 herbal drugs.experimental assessments were made on the anti-hsv-ii action of 500 herbs by determinations of the virus inhibition logarithm (vil). 13 highly effective herbs (vil greater than or equal to 4.00) were screened cut, providing a rational basis for clinical therapy. among these effective herbs, 10 were aqueous extracts of artemisia anomala, centella asiatica, epimedium sagittatum, hibiscus mutabilis, hosta plantaginea, hypericum japonicum, inula japonica, mosla punctata, rhododendron simsii, and rhu ...19892550706
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