Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| effects of panax notoginseng saponin rg1 on cardiac electrophysiological properties and ventricular fibrillation threshold in dogs. | to study the effects of rg1 isolated from saponins of panax notoginseng on cardiac electrophysiological properties and ventricular fibrillation threshold (vft). | 1995 | 8701769 |
| a comparative study on commercial samples of ginseng radix. | a total of 37 commercial samples of ginseng radix, the origins of which belonged to panax ginseng c. a. meyer, p. quinquefolia linn. (american ginseng), and p. notoginseng burkill (sanchi-ginseng), respectively, were collected from the taiwan herbal markets. the contents of nine ginsenosides, rb(1), rb(2), rc, rd, re, rf, rg(1), rg(2), r(0), and three malonylginsenosides, mrb(1), mrb(2), mrc, in these samples were determined by high-performance liquid chromatography. it was found that the saponi ... | 1995 | 17238100 |
| effects of panax notoginseng saponins on receptor-operated ca2+ channels in vascular smooth muscle. | the effects of saponins of panax notoginseng (pngs) on the alpha-adrenoceptor agonists-induced contractile responses and ca2+ movement were studied in dog mesenteric artery (ma) and saphenous vein (sv). pngs reduced the contractions and the 45ca influx (from 0.36 +/- 0.03 to 0.14 +/- 0.05 mumol.g-1 wet strip) induced by phenylephrine (phe) without effect on kcl-induced contraction and 45ca influx which were nearly completely inhibited by nifedipine 0.1 mumol.l-1. pngs did not change the 45ca eff ... | 1994 | 7717059 |
| effects of panax notoginseng saponins on myocardial adenosinetriphosphatase. | effects of total panax notoginseng saponins (pns) and panax notoginseng saponin monomers rb1 and rg1 (rb1, rg1) on total atpase and na(+)-k(+)-exchanging atpase of guinea pig heart were studied. it was found that pns inhibited the total myocardial atpase, but had no significant effect on the myocardial na(+)-k(+)-exchanging atpase. the total atpase was inhibited by rg1, and more clearly by rb1. the automaticity and contractility of isolated guinea pig atria were inhibited by rb1. rg1 decreased t ... | 1994 | 7801779 |
| the effect of chinese hepatoprotective medicines on experimental liver injury in mice. | the purpose of this study was to compare the hepatoprotective effects of seven chinese herbal compounds/mixtures on four known hepatotoxicants in mice. these compounds include fulvotomentosides oleanolic acid, total saponins of panax japonicus (jgs), total saponins of panax notoginseng (ngs), sweroside, oxymatrine, and dimethyl dicarboxylate biphenyl (ddb). all have previously been reported to exhibit hepatoprotective effects. acute liver injury was produced in male cf-1 mice by ccl4, acetaminop ... | 1994 | 7934088 |
| effect of notoginsenoside r1 on the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells. | among other chinese herb drugs, panax notoginseng is used to treat cardiovascular diseases. to elucidate any possible effects of this drug on the hemostatic system in vitro, we analyzed the influence of one of its major active constituents on fibrinolytic parameters of cultured human umbilical vein endothelial cells (huvecs). when confluent cultures of huvecs (passages 2 to 3) were conditioned with purified notoginsenoside r1 (nr1), a dose- (0.01 to 100 micrograms nr1/ml) and time-dependent incr ... | 1994 | 8018658 |
| [effects and mechanism of total saponins of panax notoginseng on anti-inflammation and analgesia]. | in this study the effects of total saponins of panax notoginseng (tspn) and electroacupuncture (ea) were compared. liquid paraffin was intraperitoneally injected (0.1 ml/mouse) to establish the animal model with inflammation. the mice were randomly divided into 4 groups with different treatments for 7 days: ea group, tspn group (100 mg.kg intraperitoneal administration), naloxone (nx) plus tspn group and ea plus tspn group. the pain threshold was measured by a detector (eq-9e) and the nitroblue ... | 1994 | 8044000 |
| [clinical effect and experimental study of xijian tongshuan pill]. | xijian tongshuan pill (xjts), consisted of siegesbeckia orientalis, moschus moschiferus, hirudo nipponica, prunus persicae, carthamus tinctoruis, ligusticum wallichi, panax notoginseng, angelica sinensis, borneolum, etc, were used in treating 70 patients with cerebral thrombosis. the marked effective rate was 82.9%, total effective rate was 96.7%. in control group a, dextranum and venoruton were used, in control group b cyclandelate capsule were used. the marked effective rate was 61.7% and 61.1 ... | 1994 | 8044010 |
| effect of panax notoginseng saponins on increased proliferation of cultured aortic smooth muscle cells stimulated by hypercholesterolemic serum. | panax notoginseng saponins (pns) was extracted from a chinese herb medicine. after preparation of cultured aortic smooth muscle cell (smc) from primary aortic explants, the cytotoxicity of hypercholesterolemic serum (hcs) for cultured cells was determined by trypan blue exclusion test, and [3h]thymidine incorporation and cell numbers were counted at the same time. the results showed that hcs (0.5 mg cholesterol.ml-1) increased the incorporation of [3h]thymidine into cultured cells (3722 +/- 440 ... | 1993 | 8249623 |
| [blood-lipid decreasing action of total saponins of panax notoginseng (burk.) f.h. chen]. | blood-lipid decreasing action of total saponins of panax notoginseng was studied. the results showed that after the saponins were given po 100 mg/kg and 200 mg/kg to rats and quails, two high lipid model animals, for seven days, their tch and tg were evidently decreased (p < 0.05). | 1993 | 8274218 |
| [effects of panaxatriol saponins (pts) isolated from panax notoginseng on the action potential and delayed rectifier current (ix) in sheep cardiac purkinje fibers]. | the electrophysiological effects of pts in sheep cardiac purkinje fibers were studied. pts was shown to increase the duration of action potential (apd30, apd50 and apd90) at the concentrations of 2.5 micrograms/ml and 5.0 micrograms/ml. however, the amplitude of action potential (apa) remained unchanged. the result of using double microelectrode voltage clamp method showed that pts (1.25-10.0 micrograms/ml) depressed the delayed (outward) rectifier current (ix) in time- and dose-dependent manner ... | 1993 | 8328288 |
| [a prospective clinical study on reversion of 200 precancerous patients with hua-sheng-ping]. | 200 precancerous patients were treated by the drug hua-sheng-ping, the process was monitored by endoscopic histo-pathologic examination, and biochemical criteria. results: the total effective rate was 95.5%, which was higher than that of control group (57%), p < 0.01. the recipe is composed of some medicinal herbs such as chrysanthemum morifolium, glycyrrhiza uralensis, panax notoginseng. it is indicated for syndromes such as spleen-stomach asthenic cold etc. and has been proved to be an effecti ... | 1993 | 8339031 |
| [effects of panaxadiol saponins isolated from panax notoginseng on intracellular and extracellular calcium]. | panaxadiol saponins (pds) contain saponins panax notoginseng b1 and e. the spontaneous beating induced by isoproterenol in isolated rat right atria and the increase of contractile force induced by ca2+ in isolated guinea pig colon were inhibited by pds 75 and 150 micrograms.ml-1, respectively and perhexiline 6.25 and 12.5 mumol.l-1, respectively. it suggested that pds could block the potential-dependent and receptor-operated calcium channel in smooth muscle. pds 150 micrograms.ml-1 and perhexili ... | 1993 | 8010067 |
| [studies on film-covered soil setting seedling of panax notoginseng (burk.) f.h. chengfu]. | film-covered soil setting seedling can markedly raise the yield of seedling and seedling establishment of panax notoginseng, thus providing higher economic benefit. the increase of yield in trial plots was about 8.82%-24% higher than the control. | 1992 | 1292489 |
| [effect of panaxatriol saponins isolated from panax notoginseng (pts) on myocardial ischemic arrhythmia in mice and rats]. | pts, one of the major effective components of panax notoginseng was found to exert remarked antiarrhythmic activities on coronary artery ligation induced ischemic and reperfused arrhythmias in rats. pts also reduced the size of myocardial infarct. for i.v. cacl2-ach induced atrial fibrillation and/or flutter in mice, pts produced a significant protective effect. in addition, pts showed an action of prolonging the life under the condition of normobaric hypoxia. | 1992 | 1293932 |
| [saponins in the fruit pedicels of panax notoginseng (burk.) f.h. chen (continue)]. | six saponins were isolated from the fruit pedicels of panax notoginseng. five of them were identified as gypenoside-xvii, -xv, ginsenoside-rb1, and notoginsenoside-fc, -fa on the basis of chemical methods, spectroscopic analysis and comparison with authentic standards. quantitative determination of the major saponins in fruit pedicels from the plant was made by thin layer chromatography-densitometry. | 1992 | 1294178 |
| [comparative effects of panax notoginseng saponins, verapamil, and norepinephrine on cerebral circulation in anesthetized rats and rabbits]. | in urethane-anesthetized new zealand rabbits, mean blood pressure (mbp) and cerebrovascular resistance (cvr) fell by 27-47% and 11-17% (p < 0.05), respectively after panax notoginseng saponins (pns) 20-80 mg.kg-1 i.v. verapamil (ver) 30 micrograms.kg-1 i.v. showed similar effects, but norepinephrine (ne) 30 micrograms.kg-1 i.v. showed opposite effects. pns and ver reduced the mbp and cvr in sodium pentobarbital-anesthetized wistar rats. the actions of pns and ver on cerebral blood flow (cbf) wer ... | 1992 | 1302439 |
| [effects of panax notoginseng saponins on monophasic action potentials of heart and automaticity and contractility of isolated atria]. | the effects of panax notoginseng saponins (pns) on monophasic action potentials (map) recorded from the myocardial surface by means of contact electrode were studied in 30 open-chest rabbits. the mapa was increased and mapd50, mapd90 were prolonged with pns (100, 200 mg.kg-1, iv), while the vmax remained unchanged. pns (300-1200 micrograms.ml-1) inhibited the automaticity of isolated guinea pig right atria and the contractility of the left atria. the positive inotropic action of ouabain (0.2 mum ... | 1992 | 1302443 |
| [saponins in fruits pedicels of panax notoginseng (burk.). f.h. chen]. | six saponins were isolated from the fruit pedicels of panax notoginseng for the first time. they were identified as ginsenoside-rc, -rb3, -re, notoginsenoside-fe, -r1 and gypenoside ix by chemical and spectroscopic analysis. | 1992 | 1418533 |
| [effects of artificial cultured panax notoginseng cell on cardiovascular system]. | alcoholic extract from artificial cultured panax notoginseng cell (scc) ip has been found conducive to increasing the resistance of mice to anoxia. in vitro it helps to increase the outflow of coronary vessels, decrease the heart rate, inhibit the constriction of aortic strip stimulated by nor-epinephrine and relax spasmodic constriction of ileum smooth muscles markedly. scc powder suspension on po administration can contract bleeding and coagulation time. the pharmacologic activities of scc are ... | 1992 | 1418584 |
| [a preliminary survey on zhuang nationality medicinal crops at traditional herbs market of jingxi county in guangxi zhuang autonomous region]. | this paper reports an investigation and study on the zhuang nationality medicinal crops available on the traditional herbs market in jingxi county of guangxi zhuang autonomous region. there are 380 species belonging to 129 families and 322 genus, among which notably embelia parviflora, malus doumeri, panax notoginseng, polygala fallax, etc. this study may serve as a reference for exploitation and utilization of the zhuang nationality medicinal herbs resources. | 1992 | 1524671 |
| effects of saponins of panax notoginseng on sodium-potassium-adenosine triphosphatase and calcium-magnesium-adenosine triphosphatase. | rat brain synaptosomal na(+)-k(+)-atpase was activated by panax notoginseng (pns, 0.1-1.0 mg.ml-1), fraction rb1 (25-200 micrograms.ml-1), and fraction rg1 (50-200 micrograms.ml-1). activating rates were respectively 84-227%, 12-48%, and 12-22%. results implied that rb1 and rg1 were not the major components of pns, which were responsible for the activating effects. ca(2+)-mg(2+)-atpase was inhibited by pns (0.1-1.0 mg.ml-1) and rb1 (100-200 micrograms.ml-1), but not by rg1. it was proposed that ... | 1991 | 1668565 |
| reduction of cellular damage induced by cerebral ischemia in rats. | a model of incomplete cerebral ischemia involving bilateral ligation of the common carotid arteries in rats, was used to examine the potential of a chinese herbal preparation and of nifedipine to reduce cell damage following cerebral ischemia. the herbal preparation contained ginsengosides and extracts of panax notoginseng, ligusticum chuanxiong hort., carthamus tinctorius l. and salvia militorrhiza bge. histological evidence of cell damage and the formation of peroxidation products were both re ... | 1991 | 1791915 |
| [separation and identification of main medicinal saponin components from mass cell cultures of panax notoginseng (burk) f. h. chen]. | five main saponins were separated from the cell cultures of panax notoginseng (burk) f. h. chen. they were sanchinoside rb1, re, r1, rg1 and rh1 identified by tlc, hplc, ir, m. p., 13cnmr and ei-ms. saponin components of the cell cultures were almost the same as those of the cultivated plants. but the content of saponins was different between the cell cultures and the cultivated plants. saponin extraction and separation procedure suitable for the cell cultures has to be different from that for t ... | 1991 | 1823984 |
| immunomodulating chinese herbal medicines. | traditional chinese medicine always pays close attention to the strengthening of the patient's general resistance against illness, there are many chinese herbs used for thousands of years are considered as tonics. animal experiments and modern clinical trails have shown that quite a number herbs are immunologically active, and most of the tonics are excellent immunomodulating agents, such as polysaccharides or saponins isolated from astragalus mongholicus, acanthopanax senticosus and panax notog ... | 1991 | 1841992 |
| [hypoglycemic effect of sanchinoside c1 in alloxan-diabetic mice]. | sanchinoside c1 (ginsenoside rg1), one of the major effective components of panax notoginseng, was reported to be effective in lowering glucose-induced hyperglycemia and synergizing the action of insulin in normal animals. the present study was aimed at investigating its effects on diabetic animals and comparing them with that of insulin. the results showed that sanchinoside c1 was able to lower plasma glucose level in alloxan-diabetic mice. the action was strengthened with repeated administrati ... | 1991 | 1950574 |
| [effects of total saponins of panax notoginseng on ca2+ influx into myocardial cells]. | using simultaneous recording of action potential (ap) and contractile force (fc) in right ventricle papillary muscle of guinea pig and measurement of 45ca uptake by cultured myocardial cells of neonatal rat, the effects of total saponins of panax notoginseng (pns) on the ca2+ influx into myocardial cells were studied. the duration of the fast ap was shortened, fc was decreased and the maximal upstroke velocity and amplitude of the slow ap were depressed by pns. the 45ca uptake by cultured myocar ... | 1990 | 1965091 |
| [effects of total saponins of panax notoginseng on increasing pgi2 in carotid artery and decreasing txa2 in blood platelets]. | total saponins of panax notoginseng (pns) were given orally 100 mg/(kg.d) to rabbit for 8 wk. aortic atherosclerotic plaque formation was restrained as compared to the control group. radioimmunoassay was used to investigate the effects of pns on the contents of prostacyclin in carotid artery and thromboxane a2 in blood platelets of rat. oral administration of pns 25,50,100 mg/(kg.d) for 10 d, the caused an increase of prostacyclin in carotid artery and a decrease of thromboxane a2 in blood plate ... | 1990 | 2119543 |
| [protective effects of panax notoginseng saponins on experimental myocardial injury induced by ischemia and reperfusion in rat]. | effects of total saponins of panax notoginseng (pns) and purified ginsenosides rb1 and rg1 from pns on myocardial injury induced by cardiac ischemia and reperfusion were studied with rat hearts in situ and in vitro. in pentobarbital-anesthetized rats, pns pretreatment (100 and 200 mg/kg) provided significant reduction in myocardial infarct size after left descending coronary artery ligation (40 min) and reperfusion (120 min) in comparison with the control. pns 12.5 and 25 mg/l, rb1 10 mg/l, and ... | 1990 | 2403009 |
| establishment of panax notoginseng tissue culture. | calli were induced from panax notoginseng roots, tubers, stems, petioles, leaves, and flower buds, and preliminary identification of medicinal compounds in the callus was carried out by tlc, using subcultured sixth-generation calli. the results demonstrated that callus was capable of synthesizing saponins, including ginsenosides rb1, rg1, and rh1. the saponin content (5.33%, d.w.) in the callus was higher than that in intact plants (4.25%, d.w.). callus also produced a larger amount of sapogenin ... | 1989 | 2491311 |
| [effects of panax notoginseng saponin rb1 and rg1 on myocardial action potential and slow inward current]. | the effects of rb1, rg1 (purified saponin of panax notoginseng) on contraction force, action potential and slow inward current of guinea pig papillary muscles were studied by intracellular microelectrodes and voltage clamp techniques. the contraction force was decreased and the apd20 was shortened in the presence of rb1 1 mg/ml, while the rp, apa and vmax remained unchanged. the amplitude of isi was decreased from a peak value of 9.8 +/- 1.6 to 7.3 +/- 3.4 microa after 20 min perfusion with rb1 ... | 1989 | 2641849 |
| [effects of panax notoginseng saponins on cardiac action potentials and slow inward current]. | the effects of total saponins of panax notoginseng (pns) on contraction force, normal and slow response action potentials and slow inward current of guinea pig papillary muscles were studied by intracellular microelectrodes and voltage clamp techniques. the contraction force was decreased and the apd20, apd90 of normal ap were shortened in the presence of pns 1 mg/ml, while the rp, apa and vmax remained unchanged. the apa of slow ap induced with high k+ was decreased to 85% of its normal value a ... | 1989 | 2816411 |
| [effects of panax notoginseng saponins on hemorrhagic shock in rabbits]. | 1988 | 3188935 | |
| [depressant actions of panax notoginseng saponins on vascular smooth muscles]. | 1988 | 3188952 | |
| [negative chronotropic and inotropic effects of panax notoginseng saponins]. | 1988 | 3218533 | |
| [effect of sapogenins from the leaves of panax notoginseng on migraine]. | 1988 | 3248333 | |
| [studies on anti-arrhythmia effects of panaxatriol saponins isolated from panax notoginseng]. | 1988 | 3421105 | |
| [studies on the flavonoids from the leaves of panax notoginseng (burk.) f. h. chen]. | 1987 | 3446380 | |
| calcium antagonistic action of saponins from panax notoginseng (sanqi-ginseng). | 1987 | 3448392 | |
| sanchinan-a, a reticuloendothelial system activating arabinogalactan from sanchi-ginseng (roots of panax notoginseng). | 1987 | 3602143 | |
| [pharmacological studies on notoginseng saponins isolated from the fibrous root of panax notoginseng]. | 1987 | 2957098 | |
| [anti-inflammatory effects of total saponins of panax notoginseng]. | 1986 | 2954374 | |
| cardiovascular pharmacology of panax notoginseng (burk) f.h. chen and salvia miltiorrhiza. | the cardiovascular pharmacology of two chinese herbs, salvia miltiorrhiza (sm) and panax notoginseng (burk) f. h. chen (png) were studied both in vivo and in vitro. extracts of both herbs suppressed systemic blood pressure in albino rats and rabbits, an effect which was blocked or reversed by atropine, propranolol, and chlorpheniramine plus cimetidine. this reversed hypertension was blocked by phenoxybenzamine. these results indicate that these herbs have multiple effector sites in the cardiovas ... | 1986 | 3799531 |
| [isolation and identification of sanchinoside b1 and b2 from rootlets of panax notoginseng (burk.) f. h. chen]. | 1985 | 4072700 | |
| [research on the plant of panax notoginseng]. | 1985 | 2938783 | |
| [anti-arrhythmic effect of total saponins of panax notoginseng]. | 1984 | 6087608 | |
| [effect of total saponins of panax notoginseng on adrenocortical function of rats and guinea pigs]. | 1984 | 6232822 | |
| [analgesic and central nervous system inhibiting effects of total saponins extracted from the leaves of panax notoginseng]. | 1984 | 6237766 | |
| [cardiac and hemodynamic effect of total saponins of panax notoginseng]. | 1984 | 6239510 | |
| [sapogenins from rootlets of panax notoginseng]. | 1984 | 6242107 | |
| [sapogenins in the flower buds of panax notoginseng]. | 1984 | 6242382 | |
| [effect of panax notoginseng on experimental disseminated intravascular coagulation (dic)]. | 1984 | 6502462 | |
| an oxepane derivative of panaxadiol from the leaves of panax notoginseng. | hydrolysis of the crude saponin isolated from the leaves of panax notoginseng (burk.) f. h. chen yields five sapogenins which are separated by column chromatography. the structures of four of those were elucidated earlier to be panaxadiol, panaxatriol, dammar-20(22)en-3beta, 12beta,26-triol and 20(r)-dammaran-3beta, 12beta,20,25-tetrol. the fifth sapogenin is identified as an oxepane derivative probably arising from acid catalyzed dehydration and rearrangement of panaxadiol. the structure as pro ... | 1984 | 17340249 |
| [hemodynamic effects of san chi (panax notoginseng) root, leaf, flower and saponins on anesthetized dogs]. | 1983 | 6679973 | |
| [effects of general saponin of panax notoginseng and sanchinoside c1 on blood sugar in experimental animals (author's transl)]. | 1982 | 7102339 | |
| [studies of the effects of gynura segetum and panax notoginseng on the ultrastructure of platelets in guinea-pigs]. | 1982 | 7168330 | |
| [two new dammaran sapogenins from leaves of panax notoginseng.]. | hydrolysis of the crude saponin extracted from the leaves of panax notoginseng (b urk.) f. h. c hen yields five sapogenins which are separated by column chromatography. two of these are identified to be panaxadiol and panaxatriol whose structures were elucidated earlier. the third sapogenin ist found to be dammar-20(22)en-3beta, 12beta,-26-triol by carbon-13 nmr. the structure of the fourth sapogenin is established by x-ray diffractometry and carbon-13 nmr to be 20 ( r)-dammaran-3beta, 12beta, 2 ... | 1982 | 17396906 |
| dammarane saponins of flower buds of panax notoginseng (sanchi-ginseng). | 1982 | 17402096 | |
| [studies on antihemorrhagic principles in the crude drugs for hemostatics. ii. on antihemorrhagic principle in sanchi ginseng radix (author's transl)]. | 1981 | 7320834 | |
| [an analysis of ddt residue in panax notoginseng (author's transl)]. | 1981 | 6211266 | |
| [chemical studies of san-chi panax notoginseng (burk.) f. h. chen. i. studies on the constituents of san-chi root hairs]. | 1980 | 7457155 |