Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| laboratory suncus: a new model animal for tonsil research. | palatine and tubal tonsils of normal and horseradish peroxidase (hrp) sensitized laboratory suncuses (suncus murinus) were examined by immunoelectron microscopy. the individual tonsil consisted of lymphoepithelial symbiosis containing m cells and a lymph nodule. the high-endothelial venules and efferent lymphatics were situated in the parafollicular region of the nodule. staining of the frozen tonsil sections by our recently developed anti-suncus t and b lymphocyte monoclonal antibodies revealed ... | 1996 | 9082781 |
| preference of lymphocyte-homing to high endothelial venules in palatine tonsils of musk shrew (suncus murinus). | we studied the lymphocyte-homing to palatine tonsils of the musk shrew, a new experimental animal originally developed in japan. the tonsils of the animals have typically high endothelial venules (hev) in the parafollicular region. the in vivo migration test showed that blood-circulating lymphocytes were able to home to the tonsils through the hev. the in vitro lymphocyte-hev binding assay clearly indicated the binding preference of the lymphocytes to be the tonsillar hev. first, binding of b ce ... | 1996 | 9082798 |
| prevalence of rat fleas in and around delhi (india) area and their susceptibility status to insecticides. | a rapid survey in delhi and surrounding areas was undertaken in september 1994, during plague outbreak in district beed (maharashtra) and surat (gujarat) to monitor rodent/flea population and to determine susceptibility status of fleas to insecticides. the five rodent species in order of their prevalence were rattus rattus (86.06%), mus musculus (15.33%), suncus murinus (2.47%), bandicoota indica (0.48%) and b. bengalensis (0.48%). two flea species, xenopsylla cheopis and x. astia, were captured ... | 1996 | 8806038 |
| the pharmacology of the emetic response to upper gastrointestinal tract stimulation in suncus murinus. | this paper is the first to describe aspects of the mechanics of retching in the insectivore suncus murinus (house musk shrew) and in an animal of such a small size (approximately 50 g). in anaesthetised animals using the novel stimulus of mechanical stimulation of the upper gastrointestinal tract as the provocative stimulus the frequency of retching was found to be about 4 retches/s, a much higher frequency than in other species (dog, cat, ferret). these studies show that quantification of retch ... | 1996 | 8836619 |
| gr205171: a novel antagonist with high affinity for the tachykinin nk1 receptor, and potent broad-spectrum anti-emetic activity. | it has been demonstrated recently that antagonists of the tachykinin nk1 receptor, specifically cp-99,994 and gr203040, possess anti-emetic activity in a range of species. to optimise this activity, a series of analogues based around the structure of gr203040 have been synthesised and their affinity at the human tachykinin nk1 receptor determined. in addition, the potency of these analogues to inhibit emesis induced in the ferret by whole-body x-irradiation has been examined. a range of substitu ... | 1996 | 8876035 |
| seroepidemiology of hantaan virus infection in taiwan. | in order to investigate the infection rate of hantaan virus in taiwan, a total of 6,536 human serum samples were collected from residents, selected by stratified random sampling, from 19 townships covering four different ethnic groups: aborigines, fukien taiwanese, hakka taiwanese, and mainland chinese. serum samples were screened for hantaan virus antibodies by indirect immunofluorescence. the prototype hantaan virus (76/118)-infected vero e6 cells were used as the viral antigen for the antibod ... | 1996 | 8950687 |
| distribution of alpha- and beta-subunits of glycoprotein hormones in thyrogonadotroph in the anterior pituitary cells of the musk shrew (suncus murinus). | in order to examine the distribution pattern of alpha- and beta-subunits of glycoprotein hormones in small and large granules in the thyrogonadotrophs of the musk shrew, we used an antiserum against a synthesized peptide consisting of the sequence 37-53 of the rat alpha-subunit, which is highly conservative among several mammalian species, and also antisera to lh beta, fsh beta and tsh beta. both alpha- and lh beta-subunits were colocalized in what appeared at the light-microscopic level to be t ... | 1996 | 8993627 |
| [mechanisms of cytotoxic drug-induced emesis and its prevention]. | in this review, i have attempted to provide an overview of the pathways by which cytotoxic drugs induce emesis. the mechanisms of serotonin 5-ht3 antagonists and new antiemetics are also discussed. old data especially from the experiments employing area postrema ablation must be re-evaluated because it is likely that the operation has damaged other important nucleus in the brain stem. therefore, the concept of the chemoreceptor trigger zone and "vomiting center" proposed by borison et al. in 195 ... | 1996 | 8855716 |
| developmental pattern of axonal pathways in the house shrew maxillary nerve. | the topographic patterns of peripheral receptors and effectors seem to contribute to the construction of the neuronal circuit in the central nervous system (cns) in mammals. many patterns replicating those of the periphery have been found in the cns, and fasciculation has been regarded as having a central role in the pattern replication. the house shrew, suncus murinus, is an excellent species in which to study this topic because it has a vibrissae system arranged in a single ordered fashion and ... | 1996 | 8849667 |
| prophylactic effect of serotonin uptake inhibitors against motion sickness in suncus murinus. | the prophylactic effect of serotonin uptake inhibitors, imipramine and fluoxetine, against motion sickness was investigated in suncus murinus. imipramine (s.c.) and fluoxetine (i.p.) inhibited motion-induced emesis dose dependently with id50 values of 1.7 and 26 mg/kg, respectively. the results suggest that increasing the concentration of serotonin in the synaptic cleft can prevent motion-induced emesis and that serotonin uptake inhibitors are effective as anti-motion sickness drugs. | 1996 | 8864690 |
| hair growth and skin in the kinky-coat (kc) musk shrew, suncus murinus. | hair growth and skin structure were examined in kinky coat (kc) musk shrews, suncus murinus. the first hair growth cycle and the development of hair bulbs were normal. histological characteristics of hair follicles and bulbs were similar in kc/kc and normal +/kc shrews. the mean thickness of epidermis and dermis did not differ significantly between the kc/kc and +/kc shrews. and no histological abnormalities were observed in the epidermis, dermis and hypodermis of the kc/kc shrews. consequently, ... | 1996 | 8840138 |
| liver apoptosis after dimethylnitrosamine administration in shrews. | female house musk shrews (suncus murinus, insectivora) were given a single i.p. dose of 30 mg/kg dimethylnitrosamine (dmn) at 8 weeks of age which was lethal 36 to 48 hrs after dosing. liver tissues were collected from shrews killed 3, 6, 16, 24 and 36 hrs after treatment, and the sequential development of the lesions was characterized. dmn induced acute centrilobular cell injury. in 6 hrs, a few cells became apoptotic in the centrilobular area; the number increased at 16 hrs and 24 hrs, and was ... | 1996 | 8811299 |
| presence and structure of anal and vaginal tonsils in the laboratory shrew (suncus murinus). | in all the laboratory shrews (suncus murinus) examined, a pair of tonsil-like structures was found at the boundary between the anus and the ostium urogenitoanalis. moreover, the same tissues were recognized between the vagina and the ostium urogenitoanalis in 9 of the 13 females examined. they indicated clear epitheliolymphocyte symbiosis around both mucosal crypts (anal and vaginal crypts) and outer lymph nodules including the germinal centers, and were demarcated from other tissues by the fibr ... | 1996 | 8712373 |
| marked depression of radiation-induced emesis by olfactory bulbectomy or pre-exposure using low doses. | acute emetic response to relatively low-doses of x-irradiation on suncus (suncus murinus) was examined. the behaviors recorded for each subject, using a video-cassette recorder system, were (1) the number of emesis, during exposure to a dose of 3.0 gy; (2) emesis threshold. results showed that the emetic threshold was observed at 0.85 gy, and the number of radioemesis during exposure was 29. however, the observed threshold dose became 2.22 gy following olfactory bulbectomy. the emetic number dec ... | 1996 | 8631391 |
| development of a laboratory colony of the musk shrew (suncus murinus, insectivora) exhibiting a high incidence of spontaneous diabetes mellitus. | 1996 | 8699804 | |
| chemical features of monoaminergic and non-monoaminergic neurons in the brain of laboratory shrew (suncus murinus) are changed by systemic administration of monoamine precursors. | 5-hydroxy-l-tryptophan (5-htp) and l-3,4-dihydroxyphenylalanine (l-dopa) were injected intraperitoneally (i.p.) into the laboratory shrew (suncus murinus). immunocytochemical and immunofluorescence studies were carried out on serial or same sections of the brain, which were reacted with specific antisera to dopamine (da) or serotonin (5-ht) produced in our laboratory. we observed that cell bodies and nerve terminals of many catecholaminergic (canergic) neurons exhibited 5-htp uptake and conversi ... | 1995 | 8848292 |
| enantiospecific inhibition of emesis induced by nicotine in the house musk shrew (suncus murinus) by the neurokinin1 (nk1) receptor antagonist cp-99,994. | effects of the nk1 receptor antagonist cp-99,994 on nicotine-induced emesis were examined in suncus murinus. cp-99,994 (3 and 10 mg/kg i.p.) attenuated emesis to (-)nicotine (4 mg/kg s.c.). cp-100,263 (3 and 10 mg/kg i.p.), the enantiomer of cp-99,994 with 1000 fold lower affinity for the nk1 receptor was without effect and rp67580 reduced emesis only at a dose of 30 mg/kg i.p. responses to nk1 antagonists were ranked according to their affinities for the suncus murinus nk1 receptor. | 1995 | 8788968 |
| [histological studies on postnatal development of the musk gland in house musk shrews (suncus murinus)]. | the development of the musk gland in house musk shrews aged 0 to 21 days was studied lectin histochemically. on about 3 days of age, the musk gland could be discriminated from surrounding skin. this organ developed markedly on days 3 to 7, and its development continued to 21 days of age. histologically, on day 1, the bulges that should develop into musk glands were identified in the vicinity of hair germs. on days 3 to 7, these bulges developed markedly, and on day 21 their structure revealed al ... | 1995 | 7498330 |
| lymphoid tissue in the kidney of the musk shrew, suncus murinus. | we describe a lymphoid tissue in the kidney of the musk shrew, suncus murinus. an anatomically well organised lymphoid tissue, resembling the mucosa-associated lymphoid tissue, is associated with the epithelium of the renal pelvis and the ureter, respectively. lymphoid tissue distributed along the arcuate artery and arcuate vein is not structurally organised in centre and periphery. this tissue type is most prominently developed between blood vessels. immunocytochemistry revealed s-100-immunorea ... | 1995 | 7570577 |
| genetic variation and geographic distribution on the mitochondrial dna in local populations of the musk shrew, suncus murinus. | the musk shrew (suncus murinus) is widely distributed throughout asia and east africa. the mitochondrial dna (mtdna) of this species was analyzed in individuals from 31 local populations in nine asian countries and mauritius, using 17 restriction endonucleases. although fourteen and nine mtdna haplotypes were detected from bangladesh and nepal, respectively, one to four haplotypes were found in each southeast asian country, and one common haplotype existed in japan, philippines, vietnam, thailan ... | 1995 | 7632440 |
| mating alters gonadotropin-releasing hormone cell number and content. | female musk shrews (suncus murinus) are induced ovulators, which lack a behavioral and ovarian estrous cycle. females mate the first time they are introduced to a male, but a second or third mating, at least 24 h later, is usually required to induce ovulation. because gnrh-immunoreactive (gnrh-ir) cell numbers increase during and after exposure to a male, we hypothesized that mating promotes synthesis of this important peptide. to test this hypothesis, we examined changes in gnrh-ir cell number ... | 1995 | 7895675 |
| development of the chondrocranial base of the musk shrew, suncus murinus (insectivora). | to reveal the developmental process of the chondrocranial base of the musk shrew, suncus murinus (insectivora), light microscopic observation of serial sections and macroscopic observation with whole-mount differential staining of bone and cartilage were performed on day-17 to -22 embryos. the following unusual findings were obtained: (1) the sphenoethmoidal commissure formed a part of the posterior edge of the tectum nasi, implying that the posterior portion of the paries nasi in the mammalian ... | 1995 | 7601229 |
| blockade of motion- and cisplatin-induced emesis by a 5-ht2 receptor agonist in suncus murinus. | 1. the effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (dol), a 5-hydroxytryptamine 5-ht2a/5-ht2c receptor agonist, on motion- and cisplatin-induced emesis were studied in suncus murinus. subcutaneous injection of dol, 30 min prior to the emetic stimuli, dose-dependently blocked the emesis induced by motion sickness and cisplatin (20 mg kg-1, i.p.) with estimated id50 values of 640 and 780 micrograms kg-1, respectively. 2. alpha-methyl-5-hydroxytryptamine (alpha-me-5-ht), a periph ... | 1995 | 7780647 |
| relationships between morphometric and mitochondrial dna differentiation in laboratory strains of musk shrews (suncus murinus). | morphometric differentiation among six strains of musk shrews (suncus murinus) originating in bangladesh (ban), sri lanka (sri), and four japanese areas, nagasaki (nag), okinawa island (oki), tokunoshima island (tku), and taramajima island (tr), was examined by use of skull and external measurements. these data were compared with mitochondrial dna (mtdna) differentiation previously reported. significant sexual dimorphism was observed in all morphometric characters of the six strains, except for ... | 1995 | 7772382 |
| sedative effect of medetomidine and its reversal by atipamezole in house musk shrews (suncus murinus). | this study was undertaken to evaluate the sedative effect of medetomidine, an alpha 2-adrenoceptor agonist, and the counteractive effect of atipamezole, an antagonist to medetomidine, in house musk shrews (suncus murinus). two hundred, 300, 400, or 600 micrograms/kg of medetomidine was intraperitoneal injected into 89 house musk shrews. a sedative effect was produced in one to two minutes after injection. the dose-dependent prolongation of the sedative duration and the dose-dependent appearance ... | 1995 | 7705479 |
| the anti-emetic activity of gk-128 in suncus murinus. | in suncus murinus, various emetic responses and the anti-emetic activity of a new 5-hydroxytryptamine3 (5-ht3) receptor antagonist, gk-128 (2-[(2-methylimidazol-1-yl) methyl benzo[f]thiochromen-1-one monohydrochloride hemihydrate), were investigated. cancer chemotherapeutic agents, cisplatin and cyclophosphamide, dose-dependently induced emesis of long-lasting duration. the 5-ht3 receptor agonist, 2-methyl-5-ht, and copper sulfate also induced emesis of short duration. however, another 5-ht3 rec ... | 1995 | 8846809 |
| the broad-spectrum anti-emetic activity of the novel non-peptide tachykinin nk1 receptor antagonist gr203040. | 1. following our earlier observations that the tachykinin nk1 receptor antagonist cp-99,994 is an effective anti-emetic in ferrets, we have examined the anti-emetic effects of a more potent and novel nk1 receptor antagonist, gr203040, against various emetic stimuli in the ferret, dog and house musk shrew (suncus murinus). 2. in ferrets, gr203040 (0.1 mg kg-1 s.c. or i.v.) is effective against emesis induced by radiation, cisplatin, cyclophosphamide, copper sulphate, ipecacuanha or morphine. 3. i ... | 1995 | 8719790 |
| distribution of taste buds on the epiglottis of the rat and house shrew, with special reference to air and food pathways. | we investigated the positioning of the epiglottis in the pharyngo-laryngeal region and the distribution of taste buds on the epiglottis in the rat and house shrew, animals which have different feeding habits. in the fixed samples of both species, when the mouth was closed or slightly opened, the epiglottis was found to protrude into the nasopharyngeal hiatus above the soft palate. but it retracted from its position when the mouth was widely opened. in omnivorous rats (n = 6), the mean number (me ... | 1995 | 8559556 |
| experimental models for carcinogenesis in the house musk shrew, suncus murinus, insectivora. | animal carcinogenicity studies have mainly been performed on rodents. from the phylogenetic point of view, animals closer to humans must be included in these studies. insectivora are considered to be the most primitive placental mammals and much closer to the early primates than rodents. among the insectivora, the house musk shrew (suncus murinus, family soracidae), has been bred under laboratory condition. this animal is small having a short life span, and a comparatively low incidence of spont ... | 1995 | 8573996 |
| a novel dodecadepsipeptide, cereulide, is an emetic toxin of bacillus cereus. | a vacuole-formation substance, cereulide of bacillus cereus, is an emetic toxin in animals. both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in suncus murinus, a new animal model of emesis. vagotomy or a 5-ht3 receptor antagonist completely abolished this emetic effect. therefore, cereulide causes emesis through the 5-ht3 receptor and stimulation of the vagus afferent. we also found that our purified cereulide caused swelling of mitochondria of hep ... | 1995 | 7781985 |
| evidence for the lack of hepatic n-acetyltransferase in suncus (suncus murinus). | the abilities of liver cytosol fractions from the suncus and sprague-dawley (sd) rats to n-acetylate aniline, p-aminobenzoic acid, p-aminosalicylic acid and 2-aminofluorene (af) were compared. the cytosol from rats n-acetylated these substrates at efficient rates, whereas the cytosol from the suncus did not n-acetylate these substrates at detectable rates. when af was given to the suncus, 2-acetylaminofluorene (aaf), a metabolite of af formed by n-acetyltransferase (nat), was not detectable in s ... | 1995 | 7488230 |
| collagen fibrils in the odontoblast layer in the teeth of the rat and the house shrew, suncus murinus, by scanning electron microscopy using a maceration method. | it is not well known whether there are gaps in the tight junctions between odontoblasts and whether the fluid flows from the pulp to the predentin through these gaps. the collagen fibrils in the odontoblast layer were investigated using a maceration method in order to show the existence of the gaps between tight junctions of the odontoblasts. the mandibles containing teeth of the rat and the house shrew were digested by naoh maceration and revealed the architecture of the collagen fibrils under ... | 1995 | 7554943 |
| characterization of a novel brain neutral glycosphingolipid composition in house musk shrew (suncus murinus). | glycosphingolipids were extracted from the brain of house musk shrew (suncus murinus). neutral glycosphingolipids were purified by qae-sephadex column chromatography followed by high-performance liquid chromatography using an iatrobeads column. purified glycosphingolipids were identified by high-performance thin-layer chromatography, carbohydrate analysis, fast-atom bombardment mass spectrometry and tlc immunostaining. the ganglioside pattern was almost the same as the pattern obtained for rat b ... | 1995 | 7601161 |
| immunocytochemical identification of serotonergic supraependymal nerve fibers in the third ventricle of the house musk shrew, suncus murinus. | supraependymal fibers of the house musk shrew (suncus murinus) were examined by conventional scanning electron microscopy (sem), backscattered electron (bse) imaging of enzyme immunohistochemistry and by immunotransmission electron microscopy in the dorsal part of the third ventricular wall. in this region, ependymal cells were not so heavily ciliated and conventional sem studies showed two main categories of supraependymal fibers. the first type consisted of long fibers fasciculated which were ... | 1995 | 7625602 |
| distribution of chicken-ii gonadotropin-releasing hormone in mammalian brain. | brains of nonmammalian vertebrates typically contain multiple forms of gonadotropin-releasing hormone (gnrh). until recently, only the mammalian form of gnrh (mgnrh) had been isolated in placental mammals. biochemical and histological data show that both mgnrh and chicken-ii gnrh (cgnrh-ii) are present in a primitive placental mammal, the musk shrew (suncus murinus). similar to the case in nonmammalian species, in the musk shrew, neurons that express cgnrh-ii are located in a discrete cluster in ... | 1995 | 7673483 |
| distribution of lectin binding in the testes of the musk shrew, suncus murinus. | distribution of lectin binding in the testis of the musk shrew, suncus murinus, was investigated by light and transmission electron microscopy. not only spermatogenic cells but also sertoli cells bound some lectins. canavalia ensiformis agglutinin (con a) and wheat germ agglutinin (wga, triticum vulgaris), indicating the presence of d-mannose and n-acetyl-d-glucosamine respectively, showed an intense reaction in the acrosomal region of early to late spermatids. ricinus communis agglutinin i (rca ... | 1995 | 7591995 |
| identification of chicken gnrh ii in brains of metatherian and early-evolved eutherian species of mammals. | two molecular forms of gnrh (chicken gnrh ii and a second variant) are present in the brains of species from all the major vertebrate groups. in mammals, two forms are present in metatherian species and early-evolved eutherian species, but chicken gnrh ii has not been identified in more advanced eutherian species. we investigated the nature of gnrh molecular forms in several early-evolved mammalian species, using high performance liquid chromatography and radioimmunoassay with specific gnrh anti ... | 1994 | 7716279 |
| activities of drug-metabolizing enzymes in the liver of suncus murinus: possible lack of n-acetyltransferase activity in liver cytosol. | the amounts of several drug-metabolizing enzymes in livers of suncus murinus (suncus) were studied in comparison with rats. the content of cytochrome p450 in suncus was less than one third that seen in rats. activities of glutathione s-transferase, udp-glucuronyltransferase and arylhydroxycarbon hydroxylase in suncus were less than half those in rats. activity of flavin-containing monooxygenase in suncus was 71% that of rats. interestingly, n-acetyltransferase (nat) activity in suncus liver cyto ... | 1994 | 8153148 |
| identification of hairs of three asian commensal mammals: suncus murinus, bandicota bengalensis, and rattus exulans. | hairs of 3 major asian commensal mammals, suncus murinus (l.), bandicota bengalensis (gray and hardwicke), and rattus exulans (peale), were studied, identified, and compared with those of better-known commensal species to provide an overview of their hair morphologies. techniques were developed for authentic hair specimen collection and rapid slide mounting to aid in the timely analysis of food products. the study showed that hairs of b. bengalensis and r. exulans are easily identified to the re ... | 1994 | 8199475 |
| oxygenation of unsaturated fatty acids by hepatic microsomes of musk shrew (suncus murinus). | the cytochrome p-450-dependent monooxygenase in musk shrew (suncus; suncus murinus) liver microsomes metabolized unsaturated fatty acids (oleic, linoleic, alpha-linolenic and arachidonic acids) to a variety of oxygenated products. alpha-linolenic acid was the most active substrate. the oxygenation activity increased with an increase in the number of cis double-bonds in the c18 fatty acids. this suggests that the introduction of cis double-bonds in c18 fatty acids is important for the binding of ... | 1994 | 8205390 |
| evolution of alanine:glyoxylate aminotransferase 1 peroxisomal and mitochondrial targeting. a survey of its subcellular distribution in the livers of various representatives of the classes mammalia, aves and amphibia. | as part of a wider study on the molecular evolution of alanine:glyoxylate aminotransferase 1 (agt1) intracellular compartmentalization, we have determined the subcellular distribution of immunoreactive agt1, using postembedding protein a-gold immunoelectron microscopy, in the livers of various members of the classes mammalia, aves, and amphibia. as far as organellar distribution is concerned, three categories could be distinguished. in members of the first category (type i), all, or nearly all, ... | 1994 | 7813517 |
| absence of emetic effects of morphine and loperamide in suncus murinus. | the house musk shrew suncus murinus recently has been introduced for the study of emesis. we investigated the emetic effects of the opioids morphine (0.1-21.5 mg/kg i.p.) and loperamide (0.01-10 mg/kg i.p.) and found a complete lack of emetogenic potential. nicotine, however, dose dependently induced vomiting in the suncus with an ed50 of 8.8 mg/kg s.c. and a 100% incidence at 20 mg/kg. this drug-induced vomiting was reduced by morphine or loperamide: ed50 values obtained were 1.2 mg/kg i.p. for ... | 1994 | 8045273 |
| morphogenesis of esophageal carcinoma induced by n-methyl-n'-nitro-n-nitrosoguanidine in the house musk shrew, suncus murinus (insectivora). | the histological changes occurring in the esophageal mucosa of shrews (suncus murinus) after n-methyl-n'-nitro-n-nitrosoguanidine (mnng) treatment were investigated sequentially. six-week-old female shrews were given a 50 micrograms/ml mnng solution as drinking water for 30 weeks, and 5 selected at random were killed at 10 and 20 weeks of age, and thereafter at 5-week intervals until 45 weeks of age. controls were killed at 45 weeks of age. the mnng-induced esophageal lesion in shrews began from ... | 1994 | 7852183 |
| immunohistochemical characterization of b cells and t cells in musk shrew (suncus murinus) lymphoid tissues using monoclonal antibodies. | we have developed and characterized three monoclonal antibodies (mabs), which recognize the surface antigens of musk shrew b cells and t cells. about 30% of all lymph node cells reacted with the mab st1. staining of frozen sections showed that st1-positive cells were located in the primary lymphoid follicles of lymph nodes, and were absent in the thymus. mabs st4 and st2 were also surface-reactive. the st1-negative (about 60% of the total) lymph node cells reacted positively with st4, and about ... | 1994 | 7698900 |
| spermatogenesis and ultrastructure of a peculiar acrosomal formation in the musk shrew, suncus murinus. | spermatogenesis and acrosomal formation in the musk shrew, suncus murinus, were studied by light and transmission electron microscopy. the cycle of the seminiferous epithelium was divided into 13 stages based on the characteristics of acrosomal change and nuclear shape, appearance of meiotic figures, location of spermatids, and period of spermiation. the relative frequencies of stages 1 to 13 were 5.1, 5.9, 10.1, 8.8, 12.5, 11.5, 10.6, 7.9, 6.0, 4.8, 8.9, 3.1 and 4.8, respectively. additionally, ... | 1994 | 7649786 |
| occipital roof development in the japanese musk shrew, suncus murinus. | the occipital squama of the japanese musk shrew, suncus murinus, consists only of membrane bone which arises from the periosteal bony band of the supraoccipital cartilage. no cartilaginous tectum posterius, generally forming the dorsal border to the foramen magnum, was found in the developing chondrocranium. also additional intramembranous ossification centres were occasionally observed, and could be interpreted as being the primordium of the interparietal bone. these observations indicate that ... | 1994 | 7961150 |
| phenotypic changes of aadc-only immunopositive premammillary neurons in the brain of laboratory shrew suncus murinus by systemic administration of monoamine precursors. | after 5-hydroxy-l-tryptophan (5-htp) and l-3,4-dihydroxyphenylalanine (l-dopa) were injected i.p. in the laboratory shrew suncus murinus, immunocytochemical and immunofluorescence studies were conducted on continuous or same sections of the brain, using specific anti-tyrosine hydroxylase (th), anti-aromatic l-amino acid decarboxylase (aadc), anti-dopamine (da) and anti-serotonin (5-ht) antisera which were produced in our laboratory. the results of double-staining by the immunofluorescence method ... | 1994 | 7845627 |
| testosterone implants in specific neural sites activate female sexual behaviour. | sexual behaviour in most female mammals is regulated by oestrogen, often acting synergistically with progesterone. moreover, the most important neural site of action for oestradiol is the ventromedial nucleus. in the female musk shrew, suncus murinus, testosterone (t) activates sexual behaviour. virgin females first engage in copulatory behaviour many hours in advance of follicular development and ovulation, when plasma oestradiol levels are very low. testosterone, produced by the ovaries and th ... | 1994 | 7987373 |
| apical cell escape from the neuroepithelium and cell transformation during terminal lip fusion in the house shrew embryo. | the house shrew embryo has many cells in the ventricular lumen and on the luminal surface of the fusing terminal lip of the cephalic neural tube. the origin and fate of these cells were studied by means of light and electron microscopy, and by dii labeling in a whole-embryo culture system. the cells appeared at stage 11a and persisted until stage 12a. most of the cells seemed to originate from the neuroepithelium, as shown by frequent observations of epithelial cell escape and dii labeling analy ... | 1994 | 7526743 |
| neurofilament expression in lens cells of the house shrew, suncus murinus. | immunohistochemical analysis demonstrated that lens cells of the laboratory house shrew, suncus murinus, expressed many intracellular filaments that immunoreacted with pooled monoclonal antibodies against 70-kda, 160-kda, and 210-kda neurofilament triplet proteins. immunopositive filaments in lens cells first appeared in day 13 embryos, while the invaginating lens placode was thickening, and this immunoreactivity was still present in immature lens fiber cells of the adult animal. western blot an ... | 1994 | 7522420 |
| distinctive features of the gametes and reproductive tracts of the asian musk shrew, suncus murinus. | insectivora are of special interest as the most primitive of the eutherian mammals, but essentially nothing is known of their gamete function. in this respect, the asian musk shrew (suncus murinus), investigated in the present study, displays many idiosyncrasies. in the epididymis, the giant acrosome undergoes further stabilization, its unusual resilience being especially evident in a "rim" created by a persistent close alignment of the outer acrosomal and overlying plasma membranes. however, un ... | 1994 | 8199263 |
| effect of starving and refeeding on lipid metabolism in suncus. | we have previously reported that fatty liver is easily induced in a novel experimental animal, suncus murinus (suncus) by withholding food, and that apolipoprotein b (apo b) is not actively synthesized in the liver. in the present paper we describe the effect of starving and refeeding on lipid and lipoprotein metabolism in suncus, in order to explore the mechanisms of induction of fatty liver by starving and of its improvement by refeeding. starvation induced increase in triglyceride content and ... | 1994 | 8206866 |
| antiemetic effects of serotonergic 5-ht1a-receptor agonists in suncus murinus. | the antiemetic effects of six serotonergic 5-ht1a-receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetrarin (8-oh-dpat), 4-(4-[4-(2-pyrimidinyl)piperazin-1-yl]butyl)-2,3,4,5- tetrahydro-1,4-benzoxazepine-3,5-dione (sun8399), buspirone, gepirone, ipsapirone and tandospirone, against motion sickness were investigated in suncus murinus. subcutaneous injection of all six agonists completely and dose-dependently suppressed motion-induced emesis. pretreatment with 8-oh-dpat or sun8399 dose-dependently ... | 1994 | 8028227 |
| induction of emesis in suncus murinus by pyrogallol, a generator of free radicals. | 1. we investigated whether or not pyrogallol, a generator of free radicals, is emetogenic in suncus murinus, the house musk shrew. pyrogallol (i.p.) caused dose-dependent emesis in suncus with an ed50 value of 77.3 mg kg-1. at a dose of 128 mg kg-1, all suncus vomited with mean latency of 18.8 +/- 5.2 min and the number of vomiting episodes was 8.6 +/- 2.9. 2. the prophylactic effects of n-(2-mercaptopropionyl)-glycine (mpg), an antioxidant, and tropisetron, a 5-hydroxytryptamine3 (5-ht3) recept ... | 1994 | 8004387 |
| distribution and steroid dependence of aromatase enzyme immunoreactivity in limbic nuclei of the female musk shrew brain. | in the female musk shrew (suncus murinus) neural aromatization of testosterone to estradiol is critical for the expression of sexual behavior. to localize the brain regions capable of aromatization, we used immunocytochemistry to map the distribution of aromatase enzyme. aromatase immunoreactivity (arom-ir) has a discrete distribution primarily limited to the lateral septum (ls), central nuclei of the amygdala (ce) and the bed nucleus of the stria terminalis (bst). in these nuclei the intensity ... | 1994 | 8156384 |
| tess line: a laboratory line of the musk shrew (suncus murinus, insectivora), triple-homozygous for the curly hair (ch), cream coat-color (cr) and red-eyed dilution (rd) genes and segregating the sucrase deficients (suc/suc). | the tess line, the first tester line of the suncus has been developed. the tess shrews are homozygous for three morphological mutant genes, ch, cr and rd. the gene (suc) for sucrase activity deficiency in intestinal brush-border membranes also exists in the line, and its frequency was 34.3%. the deficients could easily be identified by the drastic body-weight losing up to more than 15% of the initial weight, that aroused two days after replacement of the drinking water for its 10%-sucrose soluti ... | 1994 | 8119332 |
| effects of iron and deferoxamine on cisplatin-induced emesis: further evidence for the role of free radicals. | the effects of ferric chloride and deferoxamine, an iron chelator, on cisplatin-induced emesis were studied in suncus murinus. pretreatment with ferric chloride (fecl3, 16-64 mg/kg) increased the number of 20 mg/kg cisplatin-induced vomiting episodes. deferoxamine (256 mg/kg) significantly reduced the number of vomiting episodes and prolonged the latency. these results further support the involvement of free radicals in the generation of cisplatin-induced emesis. | 1993 | 8181539 |
| adenosine induces contractions in suncus ileum. | purinoceptor-mediated responses were characterized in the ileum of suncus murinus. adenosine as well as adenosine 5'-triphosphate (atp) contracted the ileum in a concentration-dependent manner. contractile responses to transmural electrical stimulation were attenuated by adenosine only at high concentrations. theophylline competitively blocked the adenosine-induced contraction. atropine also inhibited the adenosine-induced contraction but in a non-competitive manner. the atp-induced contraction ... | 1993 | 8121076 |
| follicular growth rate and lack of influence of oestradiol valerate, testosterone propionate and aminoglutethimide phosphate on ovarian follicular development in the musk shrew, suncus murinus l. | growth rate of follicles and effects of administration of oestradiol valerate (ev), testosterone propionate (tp) and aminoglutethemide phosphate (agp) on the development of ovarian follicles of the adult musk shrew were investigated. the follicular growth rate was estimated by mitotic index before and 2 hr after colchicine treatment to the shrews. mitotic index of granulosa cells increased linearly with the increase in the follicular diameter. the calculated mean duration of mitosis was 0.48 hr. ... | 1993 | 8112760 |
| involvement of free radicals in cisplatin-induced emesis in suncus murinus. | the participation of free radicals in cisplatin-induced emesis was investigated in the house musk shrew, suncus murinus. thiobarbituric acid (tba) values, which indicate the degree of lipid peroxidation, in brain, liver and small intestine were increased significantly 60 min after the treatment with cisplatin (20 mg/kg, i.p.). moreover, cisplatin (20 mg/kg, i.p.)-induced emesis was prevented by intraperitoneal injection of n-(2-mercaptopropionyl)glycine (mpg), a radical scavenging agent, with id ... | 1993 | 8223958 |
| [lectin histochemical studies on the musk gland in the house musk shrew (suncus murinus)]. | the musk gland of the adult house musk shrews (suncus murinus) of both sexes was studied lectin histochemically. the musk gland was a kind of scent gland, consisted of congregation of branched or unbranched simple tubuloalveolar gland holocrine in nature and was attached by an apocrine gland-like structure (sweat gland) in the deeper layer of its periphery. acinar cells of the musk gland were distinguishable into three type from basal to luminal parts of the acinus; immature cells, mature cells ... | 1993 | 8354366 |
| [fine structure of the vomeronasal organ in the house musk shrew (suncus murinus)]. | fine structure of the vomeronasal organ (vno) was examined in an insectivore, house musk shrew (suncus murinus), from a viewpoint of comparative anatomy. the vno was a pair of tubular structure, about 6mm in length, and situated at the base of the nasal septum. the medial wall of the lumen of the vno was lined with the sensory epithelium (se) consisting of sensory, supporting and basal cells, while the respiratory epithelium (re) lining the lateral wall was pseudostratified and covered with micr ... | 1993 | 8354364 |
| x-irradiation-induced emesis in suncus murinus. | x-irradiation-induced emesis was investigated in suncus murinus, a house musk shrew. whole body x-irradiation caused emesis, and the calculated ed50 value that induced emesis in 50% of animals was 429 cgy. at the irradiation dose of 800 cgy all the animals vomited 10.0 +/- 2.4 times with a latency of 20.0 +/- 2.9 min. the emetogenic effect of x-irradiation was dependent on the part of the body exposed. abdominal x-irradiation at 1000 cgy caused emesis in all animals studied, whereas the same dos ... | 1993 | 8360859 |
| co-existence of gonadotrophins (fsh, lh) and thyrotrophin (tsh) in single anterior pituitary cells of the musk shrew, suncus murinus. | according to recent immunocytochemical studies of anterior pituitary cells, it is obvious that the "one cell-one hormone" theory must be modified. many pituitary morphologists have demonstrated that there are some cells that contain two hormones. in this study, we demonstrate by means of immuno-electronmicroscopy the co-existence of gonadotrophins (fsh and lh) and thyrotrophin (tsh) in the same anterior pituitary cells of the musk shrew. these cells were remarkably altered in their ultrastructur ... | 1993 | 8513484 |
| [diurnal rhythms in locomotor activity of the house musk shrew, suncus murinus]. | a diurnal rhythm of locomotor activity in male and female house musk shrews (jic:sun) aged approximately one year was observed under a schedule of 12 hr light and 12 hr darkness (light on at 07:00) over a period of 10 days. in general, the pattern of locomotor activity was similar in both sexes, with around 24-hr diurnal rhythm. a few typical patterns of locomotor activity in these animals were as follows: a. locomotion interval was close in the light phase, while was sparse in the dark phase. b ... | 1993 | 8462628 |
| esophageal carcinoma in house musk shrews, suncus murinus (insectivora), induced by n-methyl-n'-nitro-n-nitrosoguanidine. | female 6-week-old shrews were given a solution of n-methyl-n'-nitro-n-nitrosoguanidine (mnng) at a concentration of 50 micrograms/ml or 100 micrograms/ml in the drinking water. all 11 shrews receiving 100 micrograms/ml mnng died 8-13 days after the beginning of carcinogen administration and 6 of the 20 shrews receiving 50 micrograms/ml mnng died after 10-54 days. when animals were between 43 and 54 weeks of age, multiple esophageal lesions were evoked in all 14 that had received 50 micrograms/ml ... | 1993 | 8408184 |
| electrophysiological properties of suncus (suncus murinus) cardiac muscle. | 1. electrophysiological properties of cardiac muscle in suncus murinus were compared with those of rat and guinea pig. 2. the resting potential and resting potassium permeability were smallest in suncus heart. 3. the action potential duration in suncus was also shortest, and effects of tetraethylammonium suggested that transient outward current is well developed in suncus. 4. elicitation of slow response was very difficult in suncus, suggesting poor development of the calcium channel. | 1993 | 8102963 |
| presence and differential distribution of distinct forms of immunoreactive gonadotropin-releasing hormone in the musk shrew brain. | gonadotropin-releasing hormone (gnrh) immunoreactive cells and fibers were revealed in olfactory regions, the ventral forebrain, and in the midbrain of the musk shrew (suncus murinus). immunoreactive neurons in olfactory and telencephalic areas were specific for the mammalian form of gnrh. cell bodies in the midbrain, however, cross-reacted with an antibody specific for chicken-ii gnrh. high-performance liquid chromatography and radioimmunoassay analyses confirmed these results; high levels of c ... | 1993 | 8264863 |
| blood supply to the cranial venae cavae and the heart in the laboratory shrew (suncus murinus). | the blood supply to the cranial venae cavae on both sides and to the heart was studied macroscopically in 40 adult laboratory shrews (suncus murinus) of both sexes injected either with neoprene latex into the abdominal aorta (25 animals) or with mercox into the left ventricle (15 animals). the 1st branch of the left subclavian artery in 23 animals of the 1st group ramified caudal to the aortic arch and descended between the aorta and the trachea to supply mainly the large left cranial vena cava ... | 1993 | 8300430 |
| characterization of mycoplasma strains isolated from house musk shrews (suncus murinus) and their infectivity in mice and rats. | five mycoplasma strains isolated from house musk shrews (suncus murinus) in the central institute for experimental animals were characterized and compared with three murine mycoplasma strains, mycoplasma pulmonis m 53, m. arthritidis pg6, and m. neurolyticum type a, and with reference strain g3-5 previously isolated from a house musk shrew. these isolates fermented glucose, but did not hydrolyze urea and arginine, passed through membrane filters of 450 nm pore size, were sensitive to digitonin, ... | 1993 | 8354358 |
| characterization of serum lipoproteins from suncus: a candidate animal model for abetalipoproteinemia. | we have previously reported that fatty liver was induced in a novel experimental animal, suncus murinus (suncus), by 24-h fasting and that apolipoprotein b (apo b) was not actively synthesized in the liver. however, a faint signal of apo b mrna was detected in the liver, suggesting possible synthesis of apo b. small amounts of vldl and ldl have been separated from suncus serum by ultracentrifugation. electron microscopic study of the lipoproteins revealed the existence of small particles in vldl ... | 1993 | 8370676 |
| embryonic development of the house shrew (suncus murinus). ii. embryos at stages 11 and 12 with 13 to 29 pairs of somites, showing limb bud formation and closed cephalic neural tube. | the embryonic development of the laboratory house shrew (suncus murinus) was observed during the period from 13 to 29 pairs of somites and was compared with that of other mammalian species. this period ranged from 10 to 12 days after fertilization. embryos were allocated to stages 11a-c and 12a-c according to somitic count. these embryos were characterized by the following features. 1. the curvature of the body became gradually enhanced, changing from a parenthesis-like to a bracket-like shape. ... | 1993 | 8430900 |
| comparison of nucleotide sequences from upstream of the dq52 gene to the s mu region of immunoglobulin heavy-chain gene loci between suncus murinus, mouse and human. | the nucleotide sequence of a 4621 base pair fragment of dna, from a position upstream of dsq52 to the s mu region within immunoglobulin heavy-chain gene loci of suncus murinus was determined. the sequence contained one d gene, three jh genes and an enhancer. suncus murinus is an insectivore and is one of the most primitive mammals. both primates and rodents are thought to have originated from insectivores and to have evolved separately. we also determined the nucleotide sequence of a region betw ... | 1993 | 8464428 |
| muscle study of the musk shrew (suncus murinus riukiuanus). i. gluteal and thigh muscles. | the gluteal and thigh muscles of the musk shrew (suncus murinus riukiuanus) were macroscopically studied. the sartorius was not observed in any of the specimens examined. the gracilis was divided into two bellies. the semitendinosus had two heads of origin, the ischial and vertebral. however, most of the gluteal and thigh muscles of this animal were quite similar with respect to origin, insertion, and also nerve supply to those muscles of rodents and primates, including human beings. all the glu ... | 1993 | 8517115 |
| emetic responses of sorex unguiculatus. | we have shown previously that suncus murinus, a species of the insectivore, can vomit in response to various emetogenic stimuli. in the present study we investigated whether or not sorex unguiculatus, which belongs to different subfamily (soricinae) of insectivore, vomits in response to emetogenic drugs. subcutaneous injection of veratrine and oral administration of copper sulfate caused emesis in the animal. histological study showed that bilateral structure of the area postrema was not importa ... | 1993 | 8519299 |
| [innervation of the external ear in humans and the musk shrew]. | the external ear appears only in mammals and possesses a great diversity of forms. in addition, multiple nerves are distributed in the external ear. the nerves which are distributed in the external ear were investigated in humans and in the musk shrew (suncus murinus) in a macroscopic study. the following results were obtained. cranial nerves (cn) v, vii, x and cervical nerves supply the auricle and the external meatus in both humans and the musk shrew. branches of the third division of cn v sup ... | 1993 | 8463885 |
| retinal projections in the house musk shrew, suncus murinus, as determined by anterograde transport of wga-hrp. | retinal projections in the house musk shrew (suncus murinus) were determined by the anterograde transport of wheat germ agglutinin conjugated to horseradish peroxidase (wga-hrp). unilateral injection of wga-hrp into the vitreous body resulted in the terminal labeling of the optic projections in the suprachiasmatic nucleus (sch), the ventral (cglv) and dorsal (cgld) lateral geniculate nuclei, the intergeniculate leaflet (igl), the pretectum, the superficial layers of the superior colliculus (cs), ... | 1992 | 1472991 |
| grouping of hantaviruses by small (s) genome segment polymerase chain reaction and amplification of viral rna from wild-caught rats. | a single pair of consensus primers in the polymerase chain reaction (pcr) amplified a conserved region of the small genome segment of twenty hantavirus isolates. isolates tested included representatives of the four recognized hantaviruses, hantaan, seoul, puumala and prospect hill, as well as isolates from mus musculus (leakey), bandicota indica (thailand 749), and suncus murinus (thottapalayam). viruses from the nairovirus and phlebovirus genera yielded negative results. the amplification produ ... | 1992 | 1354416 |
| production of specific antibody against l-dopa and its ultrastructural localization of immunoreactivity in the house-shrew (suncus murinus) lateral habenular nucleus. | an antiserum was raised against l-dopa bound to bovine serum albumin, purified by affinity chromatography, and its specificities were verified by immunoblotting and enzyme-linked immunosorbent assays. the antiserum did not cross-react with dopamine (da), tyrosine, tyramine, octopamine, norepinephrine or epinephrine. immunocytochemical studies using the pap method revealed that tyrosine hydroxylase- and l-dopa positive but aromatic l-amino acid decarboxylase- and da-negative neurons were present ... | 1992 | 1359476 |
| morphological study of parafollicular cells and the parathyroid gland in the house shrew (suncus murinus). | a morphological study of parafollicular cells in the thyroid gland and parathyroid gland of the house shrew (suncus murinus) was made. the results indicated that (1) there were two pairs of parathyroid glands which were located in the upper part of the house shrew thyroid gland, (2) the volumes of the house shrew parathyroid glands ranged from 0.014 to 0.079 mm3, (3) the number of parafollicular cells along the follicles was largest in the upper part of the thyroid lobe, while no parafollicular ... | 1992 | 1436955 |
| intestinal disaccharidases in the house musk shrew, suncus murinus: occurrence of sucrase deficiency. | 1. disaccharidase activities of the small-intestinal brush border membrane were studied in six laboratory lines of the house musk shrew, suncus murinus. 2. sucrase activity was detected in all shrews of one line, but not in any shrew of three lines. in the other two lines it was found in some shrews, but not in the others. 3. maltase, isomaltase, trehalase and lactase activities were found in all shrews of all the lines examined. 4. sucrase was normally associated with isomaltase to form an enzy ... | 1992 | 1458837 |
| embryonic development of the house shrew (suncus murinus). i. embryos at stages 9 and 10 with 1 to 12 pairs of somites. | the embryonic development during the period from 1 to 12 pairs of somites was observed in an insectivore species, the house shrew (suncus murinus), which has been bred within a closed colony. embryos were staged by the number of somite pairs. each stage was punctuated at every addition of three pairs of somites and numbered after the carnegie system. the first somite became apparent between 8 and 9.0 days after fertilization, and the 12th somite appeared between 9.5 and 10.0 days. the rate of so ... | 1992 | 1514703 |
| dat-582, a novel serotonin3 receptor antagonist, is a potent and long-lasting antiemetic agent in the ferret and dog. | the antiemetic effects of a novel serotonin3 receptor antagonist, dat-582 [(6r)-(-)-n-[1-methyl-4-(3-methylbenzyl)hexahydro-1h-1,4- diazepin-6-yl]-1h-indazole-3-carboxamide dihydrochloride] were compared with those of the existing serotonin3 receptor antagonists, ondansetron and granisetron, in experimental animals. in ferrets, dat-582 (0.003-0.1 mg/kg i.v. twice) dose-relatedly prolonged the latency to the first emetic episode and decreased the number of emetic episodes induced by cisplatin (10 ... | 1992 | 1532032 |
| decrease in the content of cytochrome p450iie by fasting in liver microsomes of house musk shrew (suncus murinus). | the effects of fasting on hepatic cytochrome p450 in the mature male house musk shrew, suncus murinus (suncus), were studied by western blot analyses and enzyme assays. the content of p450iie protein was decreased, by fasting, to 24% of the control level in contrast to the results with rats, in which p450iie protein was increased to 172% by fasting. these changes reflected on catalytic activities, such as aniline hydroxylase and n-nitrosodimethylamine demethylase activities, which were decreased ... | 1992 | 1596279 |
| neural distribution of estrogen receptor immunoreactive cells in the female musk shrew. | in this report we describe the neural distribution of estrogen receptor immunoreactivity (er-ir) in the female musk shrew (suncus murinus). the highest concentrations of neurons containing er-ir were found in the preoptic areas, the lateral septum, the anterior arcuate and ventromedial nuclei of the hypothalamus, the medial nuclei of amygdala, and the midbrain central grey. additional preoptic, hypothalamic, limbic and midbrain nuclei also contained er-ir cells. the distribution of er-ir was sim ... | 1992 | 1467965 |
| mating induces puberty in the female musk shrew. | female musk shrews (suncus murinus), lacking a behavioral estrous cycle, engage in copulatory behavior whenever tested; even during pregnancy, sexual activity can be displayed. studies suggest that protracted sexual behavior has a functional significance in this species. virgin females receiving a series of ejaculations over the course of several days are more likely to ovulate and subsequently deliver than animals given the same number of ejaculations over an interval of a few hours. after the ... | 1992 | 1511100 |
| ultrastructural study of postnatal development of the tonsillar crypt epithelium of the musk shrew, suncus murinus. | an ultrastructural study was made of the postnatal development of the tonsillar crypt epithelium in the musk shrew, suncus murinus. on day 3 after birth, a particular kind of large lymphoid cell was first seen to move through the basement membrane into the epithelium. the next migration was that of lymphocytes, which passed through holes in the basement membrane. on days 5 to 7, the lymphocytes formed clusters, and pale epithelial cells of low electron density appeared. the cell clusters and pal ... | 1992 | 1416082 |
| distribution of gonadotrophins within the anterior pituitary cells of the musk shrew (suncus murinus l.). | gonadotrophs in the anterior pituitary gland of the musk shrew were first identified by means of electron microscopic immunocytochemistry. the gonadotrophs of the musk shrew revealed quite unusual ultrastructural features that have never been seen before in other species. these cells contained two types of secretory granules, i.e., small dense, round-shape granules and large lucent, irregular-shape granules. fsh beta and lh beta were mostly observed together on both small and large secretory gra ... | 1992 | 1605381 |
| mating stimulates estradiol production by ovaries of the musk shrew (suncus murinus). | asian musk shrews (suncus murinus) are induced ovulators, but exhibit no cyclic changes in reproductive structures or in sexual behavior. mating behavior is induced by contact with a male. to determine if mating induces changes in ovarian steroidogenesis, ovaries removed from unmated animals and at 3, 10, 15, and 36 h after mating were cultured for 4 h in the presence or absence of gonadotropins (lh + fsh, 1 microgram/ml). histological analysis revealed no obvious changes in follicular size or a ... | 1992 | 1591343 |
| kinky coat, a new autosomal recessive mutation in the musk shrew, suncus murinus. | a kinky-coat mutant was discovered at the fifth generation of the ban strain originating from wild musk shrews (suncus murinus) in bangladesh. mating experiments indicated that the kinky-coat character is controlled by a single autosomal recessive gene designated kc (kinky coat), which is not allelic to the gene ch (curly hair) previously reported in the tr strain derived from wild musk shrews on taramajima island, japan. because the kc/kc homozygotes were fully fertile and viable, the kc gene s ... | 1992 | 1577081 |
| red-eyed dilution (rd), a novel coat-color mutant gene in the musk shrew (suncus murinus, insectivora). | a novel coat-color mutant was found in the musk shrew (suncus murinus). mutant shrews were characterized by light-gray coat, pinkish skin and red eyes. mating experiment demonstrated that the mutant character was controlled by a single autosomal recessive gene. the gene could be traced back to at least four heterozygous carriers captured in naha city, okinawa in 1983. the name, red-eyed dilution, was proposed for this mutant character with the gene symbol rd. linkage analysis proved no close rel ... | 1992 | 1577078 |
| [establishment of an outbred strain (jic: sun) in the house musk shrew, suncus murinus]. | planned reproduction of the house musk shrew, suncus murinus was investigated using 3,016 females for mating. the birth rate and the weaning rate attained were 77.2% and 82.3%, respectively. the average litter size was 3.4. the mean value of the productive index (number of weaned individuals/number of females mated) was estimated as 2.2. the highest value of the productive index, 2.6, was recorded when the fourth litter was used for reproduction. no seasonal fluctuation in the reproductive abili ... | 1992 | 1577077 |
| inheritance and breeding of the waltzing mutant in the musk shrew (suncus murinus, insectivora) characterized by the circling and head-shaking behaviors. | a behavioral mutant was found in the laboratory-bred musk shrew (suncus murinus). the affected shrews were characterized by the behaviors of tight circling in both directions and frequent head shaking in horizontal. they could definitely be identified by at least day 10 after birth. these abnormal behaviors were steady and permanent through life. mating experiments demonstrated that the mutant character is expressed by a single autosomal recessive gene in homozygote with complete penetrance. the ... | 1992 | 1577073 |
| magnificent expression of asialo gm1 on thymus cells and spleen t cells of the musk shrew, suncus murinus. | the expression of asialo gm1 (ga1) was observed on almost all thymocytes from young musk shrew, at the age of 4 weeks by flow cytometric analysis. in adult shrew aged 10 months, the ratio of ga1-negative thymocytes was increased. among several anti-glycolipid antibodies used, anti-gm1 and anti-forssman also reacted with the thymocytes. protein fraction of the thymocytes was analyzed by sds-page followed by immunoblotting. anti-ga1 and anti-gm1 showed two bands and one band, respectively, however ... | 1992 | 1563258 |
| cisplatin-induced emesis in suncus murinus. | emetic responses to cisplatin and participation of vagal innervation in emesis were studied in suncus. intraperitoneal and intravenous administration of cisplatin caused dose-dependent emesis. ed50 values, latencies and frequencies were not significantly different between the two administrations. cis-diaqodiammineplatinum (dap), an active metabolite of cisplatin, also induced emesis, but with significantly shorter latency. vagotomy completely abolished both types of vomiting. these results sugge ... | 1992 | 1513079 |
| morphometric analysis of small follicles in the ovary of the musk shrew (suncus murinus l.) at different ages. | on the basis of morphological characteristics of granulosa cells surrounding the oocyte, the small follicles (class 1) in the ovary of the musk shrew were classified into four groups: type b (flattened cells), type b/c (mixture of flattened and cuboidal cells), type c (single layer of cuboidal cells), and type d (more than one to two layers of cuboidal cells without epitheloid cells in the theca). the pattern of small follicular development was characterized by a short early dormant followed by ... | 1992 | 1601250 |
| role of histamine in motion sickness in suncus murinus. | the levels of histamine (ha) and tele-methylhistamine (t-mh) were determined in five brain regions of suncus murinus (suncus) and the effects of motion stimulus or drugs influencing the turnover of these amines were studied to elucidate the role of histamine in motion sickness. shaking the animals for 2 min increased ha contents in telencephalon and diencephalon without significantly changing the t-mh levels. alpha-fluoromethylhistidine (alpha-fmh), which is presumed to deplete the neuronal ha, ... | 1991 | 1741719 |
| 5-hydroxytryptamine is emetogenic in the house musk shrew, suncus murinus. | the emetic effects of 5-hydroxytryptamine (5-ht) and 5-ht3 receptor agonists were investigated in the house musk shrew, suncus murinus. 5-hydroxytryptamine (5-ht; i.p., i.v., s.c.) and 2-methyl-5-ht (2-me-5-ht; i.p.) but not 5-hydroxyindoleacetic acid (i.p.) or 5-methoxytryptamine (i.p.) induced emesis with very short latency. tropisetron (ics 205-930, a 5-ht3 receptor antagonist, s.c.) blocked the emesis induced by 5-ht (10 mg/kg, i.p.) and 2-me-5-ht (5 mg/kg, i.p.) with respective id50 values ... | 1991 | 1725807 |
| tropical photoperiods affect reproductive development in the musk shrew, suncus murinus. | the purpose of the present studies was to determine whether reproductive development in male musk shrews (original stock from guam island, 13 degrees n latitude) could be altered by small, ecologically relevant changes in photoperiod. in the first experiment, effects of changes in photoperiod equivalent to those seen between the 2 solstices on guam island (90 min) on reproductive maturation were investigated. the results showed that a 90-min difference in photoperiod had a significant effect on ... | 1991 | 1801008 |
| evidence that neural aromatization of androgen regulates the expression of sexual behaviour in female musk shrews. | abstract the experiments reported on here were conducted to test the hypothesis that sexual behaviour in the female musk shrew (suncus murinus) is regulated by the neural aromatization of testosterone to oestradiol. in the first experiment ovariectomized animals received subcutaneous hormone implants containing either an aromatizable androgen (testosterone or androstenedione), a non-aromatizable androgen (dihydrotestosterone or methyltrienolone), or cholesterol. only females that received an aro ... | 1991 | 19215490 |