Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| sickness absence. | 2009 | 2654393 | |
| marketing hospice: the untold story. | 2009 | 2653366 | |
| [metrological aspects of the spectral analysis of cardiac rhythm]. | there are factors (presence of slow waves with the period that exceeds the recording duration, nonmultiplicity of the analysed oscillation periods to realisation), which do not allow reliable and reproducible estimations of the spectrum parameters in the slow area even in case of the stable patient's state. in case there are oscillations in the heart rhythm with periods comparable with the recording duration application of such a well known method like the elimination of polynominal trend to inh ... | 2009 | 2747492 |
| surgical glove perforation. | 2009 | 2765822 | |
| primary ciliary dyskinesia and young's syndrome. | 2009 | 2663254 | |
| [phenotype study of varieties of carcinomas originating in the oro-pharyngo-laryngeal mucosa. anatomo-clinical considerations]. | an immunohistological analysis with a panel of monoclonal and polyclonal antibodies was performed in 20 cases of squamous cell carcinoma originating in the oral cavity, oropharynx and larynx. the epithelial antigens were detected in all cases with variable patterns of positivity: cytokeratins and epithelial membrane antigen were positive in a high number of neoplastic cells in the carcinomas with a high grade of differentiation, whereas a lesser number of positive cells was observed in the poorl ... | 2009 | 2695818 |
| socioeconomic differences in rates of cesarean section. | increasing cesarean-section rates have focused attention on variations in the use of this procedure that appear to be independent of medical indication. we investigated the relation between the rate of primary cesarean section and socioeconomic status in a cohort of 245,854 singleton infants born to non-hispanic white, black, asian-american, and mexican-american residents of los angeles county, california. on the basis of birth-certificate data for 1982 and 1983, a significant relation, independ ... | 2009 | 2747759 |
| efficacy and toxicity elicited by recombinant interferons alpha and gamma when administered in combination to tumor-bearing mice. | administration of rhuifn-alpha a/d and rmuifn-gamma as single agents to tumor-bearing mice resulted in a dose-related antitumor effect in each of the six models studied. when the ifns were given in combination, the effects varied between the tumor systems. no increase in efficacy was seen in mice bearing b16-f10 melanoma or m5076 reticulum cell sarcoma while additive antitumor activity was shown in the ka31 fibrosarcoma and p388 leukemia systems. mice inoculated with l1210 lymphoma or colon 38 c ... | 2008 | 2562640 |
| low dose cyclosporin a therapy in chronic posterior uveitis. | nine patients with chronic posterior endogenous uveitis of varying aetiology, not satisfactorily controlled with systemic corticosteroids alone, were treated with low dose oral cyclosporin a (mean maintenance dose 4.0 +/- 1.1 mg/kg/day). six of the nine patients also continued to receive oral prednisolone (15 mg/day or less). during a follow up period of 6-30 (mean 17) months, seven have shown sustained visual improvement. nephrotoxicity was the major side effect with serum creatinine concentrat ... | 2008 | 2612672 |
| nursing, medical staffs critical to admitting doctors. | 2008 | 3391551 | |
| a practical approach to light chain typing in monoclonal gammopathy. | 2008 | 3098452 | |
| measurement of nonuniform current densities and current kinetics in aplysia neurons using a large patch method. | a large patch electrode was used to measure local currents from the cell bodies of aplysia neurons that were voltage-clamped by a two-microelectrode method. patch currents recorded at the soma cap, antipodal to the origin of the axon, and whole-cell currents were recorded simultaneously and normalized to membrane capacitance. the patch electrode could be reused and moved to different locations which allowed currents from adjacent patches on a single cell to be compared. the results show that the ... | 2008 | 2713443 |
| measurement of nonuniform current densities and current kinetics in aplysia neurons using a large patch method. | a large patch electrode was used to measure local currents from the cell bodies of aplysia neurons that were voltage-clamped by a two-microelectrode method. patch currents recorded at the soma cap, antipodal to the origin of the axon, and whole-cell currents were recorded simultaneously and normalized to membrane capacitance. the patch electrode could be reused and moved to different locations which allowed currents from adjacent patches on a single cell to be compared. the results show that the ... | 2008 | 2713443 |
| characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment. | we have studied the effect of ursodeoxycholic acid on the serum and urinary bile acids in seven patients with moderate to severe primary biliary cirrhosis. bile acids were characterized by gas-liquid chromatography-mass spectrometry and quantified by capillary gas-liquid chromatography. serum bile acids were elevated 26-fold over control values, with 2.2 times more cholic acid than chenodeoxycholic acid. urinary bile acid output was elevated 22-fold over control values with a cholic acid:chenode ... | 2008 | 2621422 |
| the concept of mental illness. | in recent years it has often been suggested that there is no such thing as mental illness. in naive cartesianism this assertion starts out from the assumption that illness may develop solely from physical causes. before clarifying what mental illness is, we should ask what is understood by the general notion of 'illness'. a constituent of the general disease concept is an unvoluntary and sufficiently serious disturbance of vital functions that needs to be defined in detail-and not just any regio ... | 2008 | 2695924 |
| attendings who never attend. | 2008 | 2772025 | |
| a preliminary blueprint: central institute of nursing. | 2008 | 2267166 | |
| [orthognathic surgical therapy. 1. preventive dentistry problems]. | 2008 | 3256773 | |
| maximal relaxation rates of esophageal, nose, and mouth pressures during a sniff reflect inspiratory muscle fatigue. | maximal relaxation rate (mrr, % pressure fall/10 msec) of the inspiratory muscles is reduced with fatigue. we have investigated whether mrr of esophageal pressure (pes) generated by voluntary sniffs is decreased by fatigue, and whether sniff nasopharyngeal (pnp) and mouth (pmo) mrr reflect these changes. in 10 normal subjects, control mrr of sniff pes correlated closely to pnp mrr (r = 0.977, p less than 0.001) and pmo mrr (r = 0.947, p less than 0.001). to produce inspiratory muscle fatigue, fo ... | 2007 | 2712448 |
| [bone mineral content in 1094 healthy residents of the taiyuan district]. | 2007 | 2168802 | |
| [diagnostic and interventional radiology in pulmonary embolism]. | the clinical picture of pulmonary embolism (pe) ist remarkably unspecific and one has to rely mainly on imaging techniques to obtain a reliable diagnosis. pe is not a primary disease but the complication of deep venous thrombosis (dvt), and thus there is a strong correlation between pulmonary embolism and venous thrombosis. radiologic screening of these diseases is based on invasive and noninvasive tests. chest x-ray has a low predictive value of 63% and helps mainly in ruling out other diagnose ... | 2007 | 1947962 |
| correlation of electrophoretic mobilities from capillary electrophoresis with physicochemical properties of proteins and peptides. | excellent correlation was observed for the electrophoretic mobilities measured by capillary zone electrophoresis versus q/mw2/3, where q is the calculated charge and mw is the molecular weight. mobilities of a set of 33 diverse peptides from enzymatic digests and 10 intact proteins were measured for separations at ph 2.35, 8.0, and 8.15 with constant ionic strength, temperature, and viscosity. the correlation suggests that the frictional drag is proportional to the surface area of a sphere that ... | 2007 | 1952066 |
| analytical methods: technical notes. | 2007 | 1951352 | |
| [aggression in the emergency service]. | 2007 | 1994106 | |
| surface properties of mussel adhesive protein component films. | mussel adhesive protein (map) is the adhesive agent used by the blue sea mussel (mytilus edulis) to attach the animal to various underwater surfaces. it is composed of 75-->85 repeating decameric units with the reported primary sequence nh2-a(1)-k(2)-p(3)-s(4)-y(5)-hyp(6)-hyp(7)-t(8)-dopa(9)-k(10)-cooh. this study identifies and compares the surface properties of the decameric unit, selected fragments and individual amino acid constituents with the complete map preparation. these molecular syste ... | 2006 | 1472585 |
| does inhibition of k+ transport in glial cells by local anaesthetics contribute to seizures? | 2006 | 2361286 | |
| [adenanthera pavonina, composition of the fat and mass spectrometric analysis of the sterolglucosides]. | 2005 | 1197419 | |
| fraction of s-phase cells in blood mononuclear cells in non-hodgkin's lymphomas--correlation with clinical features and prognosis. | a consecutive material of 111 untreated patients with non-hodgkin's lymphoma was studied with respect to fraction of s-phase cells in blood mononuclear cells in relation to presence of monoclonal b cells in blood (mbcb). fraction of s-phase cells was determined by flow cytometry and estimation of mbcb was performed by kappa:lambda analysis. the fraction of s-phase cells was significantly higher (p less than 0.001) in mbcb-positive cases (median 1.2%) than in the mbcb-negative (median 0.7%). mbcb ... | 2005 | 2785930 |
| [small shot in the appendix]. | 2005 | 1168977 | |
| [transosseous osteosynthesis in fractures of the metacarpal bones]. | 2005 | 1143767 | |
| [colonic perforation in a case of pheochromocytoma]. | 2005 | 1160218 | |
| the pursuit of happiness (and health) 200 years later. | 2005 | 1074726 | |
| [what happens when the cilia remain immobile?]. | 2005 | 1082535 | |
| letter: is that apicoectomy really necessary? | 2005 | 1061540 | |
| statistical methods that distinguish between attributes of assessment: prolongation of life versus quality of life. | the authors propose a method to generate information relevant to the decision tree that adds additional perspective to the characterization of health quality during survival. their approach uses survival data to distinguish two attributes of utility: prolongation of life and quality of life (qol). health-state transition probabilities correspond to the prolongation of life and are modeled in a discrete-time transient semi-markov process. quality-of-life-state transition probabilities are derived ... | 2003 | 1573984 |
| [treatment of postoperative digestive fistulas by perfusion-aspiration]. | the experience of the first surgical clinic from tirgu-mureş is described, concerning the treatment of postoperative digestive fistulae in a group of 13 patients. the fact is stressed that the occurrence of such fistulae is more frequent following gastrectomies with gastrojejunostomy, gastrectomies for neo-plastic lesions, extensive gastrectomies--as compared with total gastrectomies. the method i of trémolières is used with a perfusion system in which a cathether is inserted in the drain tube a ... | 2002 | 136672 |
| tests of tubal patency: comparison of laparoscopy and hysterosalpingography. | tubal patency in 86 infertile patients was investigated by hysterosalpingography and the laparoscopic methylene blue test. hysterosalpingography indicated 33 cases of interstitial tubal occlusion, 18 cases of fimbrial occlusion, and 8 cases of combined occlusions. laparoscopy indicated 28 cases of interstitial tubal occlusion, 18 cases of fimbrial occlusion, and 7 combined cases. in addition, laparoscopy revealed 57 cases of periadnexal adhesions and 13 cases of fimbrial phimosis in patients wit ... | 2002 | 137026 |
| a quantitative assessment of the cytotoxicity associated with chromosomal aberration detection in chinese hamster ovary cells. | regulatory guidelines suggest testing chemicals up to cytotoxic doses in chromosomal-aberration assays. to investigate the utility and limitations of various cytotoxicity indicators we used chinese hamster ovary (cho) cells to test 8 chemicals with differing ratios of cytotoxicity to clastogenicity. we measured immediate or delayed cell killing and growth inhibition (atp levels, cell counts, colony-forming efficiency, cfe) and cell-cycle perturbations (mitotic index, mi; average generation time, ... | 2002 | 1370242 |
| [role of laparoscopy in the diagnosis of closed injuries to the abdominal organs]. | 2002 | 135860 | |
| prognostic aspects of electroclinical and neuroendocrine data in severe brain injury. | 2001 | 113991 | |
| [study of hepatitis b antigens and antibodies in women isosensitized to the rhesus antigen]. | 1999 | 104435 | |
| juvenile xanthogranuloma (naevoxantho-endothelioma). | 1998 | 104812 | |
| lidocaine inhibits prolactin secretion in gh4c1 cells by blocking calcium influx. | the mechanism of the inhibitory effect of local anesthetics on hormone secretion was studied in the gh4c1 line of rat pituitary tumor-derived cells. lidocaine between 0.1 and 5 mm exerted significant dose-dependent inhibition on the increment in cytosol ca2+ concentration ([ca2+]i) and prolactin (prl) secretion induced by 30 mm k+. for both effects the ic50 was 0.25 mm and maximal inhibition occurred at 5 mm. a normal response returned within 20 min after removal of lidocaine from the incubation ... | 1992 | 1280232 |
| oral susceptibility of aedes albopictus to dengue type 2 virus: a study of infection kinetics, using the polymerase chain reaction for viral detection. | female aedes albopictus mosquitoes, aged 1 week, were infected with den-2 dengue virus. the kinetics of infection in mosquito brain and mesenteron were monitored using dna probes with polymerase chain reaction (pcr) amplification of target dna sequences coding for den-2 virus envelope protein, compared with the standard immunofluorescence assay technique (ifa). rates of virus detection in the mesenteron of orally infected mosquitoes rose to 38% by day 4 post-inoculation, then declined until day ... | 1992 | 1463895 |
| electroencephalographic study of rat hyperthermic seizures. | the behavior and eeg of rat hyperthermic convulsions was studied. we found that a long run of high-voltage slow waves without convulsions, high-voltage irregular activity consisting of spikes and waves with intermittent myoclonus, and rapid spike and wave bursts accompanied by generalized clonic convulsions occurred sequentially. this behavioral and eeg activity is analogous to human febrile convulsions and supports the usefulness of this model for studies of human febrile convulsions. rats freq ... | 1991 | 2044491 |
| taxonomy of leishmania. use of isoenzymes. suggestions for a new classification. | the authors propose a new classification for the genus leishmania ross, 1903 based both on the use of intrinsic and extrinsic characters and on linnean and adansonian methods. the type of vertebrate host makes it possible to recognize the genus group: leishmania designates kinetoplastida parasites of mammals. neighbouring forms which parasite reptiles are now grouped in the genus sauroleishmania ranque, 1973. characteristics of the intravectorial cycle (supra- and peri-pyloric) are used to defin ... | 1990 | 2080829 |
| [experimental study of the activity of a number of enzyme-substrate systems after inhalation of aluminum-cobalt-molybdenum catalyst]. | 1990 | 2116994 | |
| purification and characterization of the major group-specific core antigen vp7 of bluetongue virus synthesized by a recombinant baculovirus. | the major core protein, vp7, of bluetongue virus serotype 10 (btv-10) has been purified from insect cells infected with a genetically manipulated recombinant baculovirus. the high level expression of vp7 (in excess of 100 mg per litre of culture) and its presence in the soluble fraction of infected cells following lysis by detergent has allowed the purification of the protein virtually to homogeneity (95%) by a simple two-step procedure of ammonium sulphate fractionation and ion-exchange chromat ... | 1990 | 2174958 |
| disappearance of a putative da-neuron antibody following adrenal medulla transplantation: relationship to a striatal-derived da neuron trophic factor. | 1990 | 2290972 | |
| location of phosphotyrosine-containing proteins by immunocytochemistry in the rat forebrain corresponds to the distribution of the insulin receptor. | cellular regulation by certain growth factor receptors and protooncogene products involves tyrosine kinase activity with the resultant tyrosine phosphorylation of protein substrates. in the present report we describe the distribution of phosphotyrosine-containing material detected by immunocytochemistry (icc) in the rat forebrain. specificity of the affinity-purified antibody against phosphotyrosine used in the icc technique was demonstrated by the ability of phosphotyrosine and p-nitrophenyl ph ... | 1990 | 1693770 |
| transiently catecholaminergic (tc) cells in the bowel of the fetal rat: precursors of noncatecholaminergic enteric neurons. | experiments were done to study the fate of transient catecholaminergic (tc) cells that develop in the rodent gut during ontogeny. when they are first detected, at day e11 in rats, tc cells are distributed along the vagal pathway, in advance of the descending fibers of the vagus nerves, and in the foregut. the early tc cells coexpress the immunoreactivities of several neural markers, including 150-kda neurofilament protein, peripherin, microtubule associated protein (map) 5, and growth-associated ... | 1990 | 1976556 |
| [painfree treatment of burns and shorter hospital stay: plastic film over burnwound allows tissue respiration]. | 1990 | 249106 | |
| the prevalence of hantaan viruses among rattus norvegicus in tokyo in the 1960's. | during the 1960's, 15 out of 89 rats (16.8%) captured in the port area and 6 out of 59 rats (10.2%) in the suburb of tokyo were seropositive against hantaan viruses. | 1989 | 2573224 |
| whole rat embryos require methionine for neural tube closure when cultured on cow serum. | headfold-stage rat embryos, when cultured on cow serum without supplemental methionine, failed to close their neural tubes, lacked eyes and branchial arches, were abnormally shaped and were reduced in protein content compared to methionine-supplemented embryos. methionine was essential during the first 18 h of culture, a period in which neural tube closure was initiated in supplemented cultures. all cow serum samples tested were found to require methionine addition, and the methionine was not re ... | 1989 | 2600678 |
| resistance control in hypertension. | in hypertension the small arteries undergo structural changes that increase vascular resistance, both in vivo and in vitro. the hallmark of a physiological vascular amplifier is that enhanced resistance responses must occur about the resting value. for this to happen, the average radius of the resistance vessels must be narrower than normal; increased wall thickness without narrowing does not result in this type of amplification. in primary hypertension in spontaneously hypertensive rats (shr), ... | 1989 | 2681590 |
| bombesin-induced hypothermia in the insulin-treated rat: effect on tail-skin temperature. | bombesin-like peptides are widely distributed in the mammalian central nervous system and appear to participate in the regulation of a variety of autonomic functions. bombesin has been shown to alter feeding behavior, locomotor activity, and thermoregulation. microinfusion of bombesin into the preoptic area of the hypothalamus produces a reduction in core body temperature, but only if the rat has been cold-exposed, food-deprived, or pretreated with insulin. the mechanism for bombesin-induced hyp ... | 1989 | 2695893 |
| the occurrence of ectopic pregnancy with and without clomiphene citrate use in assisted and nonassisted reproductive technology. | an eleven-year review of treatment records of patients who became pregnant as a result of infertility treatment (n = 3692) was conducted. all records were examined to determine whether clomiphene citrate (cc) was used in the cycle of conception and whether or not an ectopic pregnancy occurred. data were additionally analyzed for the incidence of ectopic pregnancy with and without assisted reproductive technology (art). the incidence of ectopic pregnancy was similar between cc (3.4%) and non-cc ( ... | 1989 | 2698906 |
| possible role of ammonia in experimental cancer anorexia. | plasma concentrations of ammonia were elevated significantly in tumor-bearing rats prior to the onset of anorexia and continued to increase as the tumor grew and anorexia developed. associated with this hyperammonemia were elevated levels of brain glutamine and large neutral amino acids (phenylalanine, tyrosine, tryptophan, methionine, histidine). concentrations of the dopamine metabolites, dopac or hva were elevated in the corpus striatum, nucleus accumbens, hypothalamus and amygdala of anorect ... | 1989 | 2731036 |
| time of application of negative pressure pulses and upper airway muscle activity. | effect of upper airway pressure changes on thoracic inspiratory muscles has been shown to depend on the time of application during the breathing cycle. the present study was designed to investigate the importance of the time of application of upper airway negative pressure pulses on upper airway muscles. the upper airway was functionally isolated into a closed system in 24 anesthetized spontaneously breathing rabbits. negative pressure pulses were applied in early (within the first 200 ms) and l ... | 1989 | 2759965 |
| central baroreflex regulation by the renal nerves in anesthetized rats. | to determine whether the renal nerves affect central baroreflex regulation, the aortic depressor nerve (adn) was stimulated electrically, while blood pressure, heart rate, and splanchnic nerve activity were recorded in renal denervated and sham-operated rats anesthetized with urethane. tail cuff systolic pressure fell 6 days after renal denervation, but mean blood pressure recorded after anesthetizing with urethane did not differ between renal denervated and sham-operated rats. urinary sodium ex ... | 1989 | 2761074 |
| production of laudanosine following infusion of atracurium in man and its effects on awakening. | twenty patients were given maximal doses of atracurium or vecuronium by infusion during surgery. anaesthesia was maintained with an infusion of thiopentone, nitrous oxide and fentanyl. in patients administered atracurium, the plasma laudanosine concentration at cessation of surgery was 0.34 (sd 0.22) micrograms ml-1; there was little tendency to cumulate during operation. a 20% higher arterial concentration of thiopentone was found at awakening in patients given atracurium, suggesting cns stimul ... | 1989 | 2765346 |
| adsorptive endocytosis of lysosomal enzymes by human fibroblasts: presence of two different functional systems that deliver an acid hydrolase to lysosomes. | endocytosis of human spleen beta-glucuronidase by human fibroblasts can be completely impaired by the competitive inhibitor mannose 6-phosphate or by pretreatment with acid phosphatase or endoglycosidases h or f. however, endocytosis of bovine spleen and liver beta-glucuronidase is partially impaired by the same treatments, suggesting that the bovine enzyme contains two endocytosis recognition markers located in separate enzyme domains. the mannose 6-phosphate recognition marker seems to be resp ... | 1989 | 2913951 |
| physicochemical characterization of [3h] dhea binding in rat liver. | dehydroepiandrosterone (dhea), the native clinical steroid and steroid precursor, may have a targeted physiologic role. a high affinity (kd 2.3nm) and steroid specific [3h] dhea binding macromolecule in male sprague-dawley rat hepatic cytosol suggests that dhea may have receptor mediated physiologic action. 3[h] dhea binding was highest in the liver followed by kidney and testis cytosols. sulfhydryl reagents such as n-ethylmalemide and iodoacetamide inhibited the binding of [3h]dhea by up to 60- ... | 1988 | 2972284 |
| septic complications in patients with permanent pacemakers. | nine patients with implanted pacemakers had the diagnosis of septicaemia to endocarditis. the diagnosis was established on the basis of a repeatedly positive haemoculture. the interval since the first pacemaker implantation to the onset of sepsis to endocarditis was about 5 years. all nine patients had previous reoperation either of the pacemaker or its lead due to decubitus. while, in four patients, the route of infection was a pacemaker lead in its extravascular couse, in 5 patients the source ... | 1988 | 3069327 |
| nasopharyngeal carcinoma: result of treatment with cis-diamminedichloroplatinum ii, 5 fluorouracil, and radiation therapy. | combined ct (cddp + 5fu) and rt were given to 28 patients with npc during july 1982-may 1985. two, 1, 4, and 21 were in stages i-iv (ajc), respectively. none had distant metastasis. four did not complete the planned treatment, and one each had more or fewer ct courses than planned. the median duration of follow-up of surviving patients was 29 months (19-52,x 31.1). objective response (cr + pr) at the primary lesion was 27/28 (96.4%), whereas cr was 23/28 (82%). cr + pr and cr of the regional nod ... | 1988 | 3343153 |
| lymphocytes proliferation kinetics and sce variation after rubella vaccination. | the effect of anti-rubella vaccination on lymphocyte proliferation kinetics in vitro and on sce frequency was studied in three young women. the studies were carried out by taking blood samples before vaccination (day 0) and subsequently on days 7, 14, 28 and 42. the mitotic index (mi) shows a decrease at day 14 and 28 followed at day 42 by an increase above day 0 levels. the average cell cycle (acc) shows a decrease at day 14 followed by an increase at day 28. complex variations were also found ... | 1988 | 3352628 |
| comparison of cryofixation methods for skin biopsies from sheep infested with psoroptes ovis (acari: psoroptidae). | two methods of cryofixing skin samples from sheep infested with psoroptes ovis were compared. in one method the skin biopsy was placed in a capped vial before immersion, while the other allowed direct contact with liquid nitrogen. no statistically significant differences were found between the cryofixation methods with regard to location of p. ovis sections or engaged mouthparts. direct contact with liquid nitrogen is recommended as the preferred method for cryofixing epidermal feeding ectoparas ... | 1988 | 3388743 |
| topographically selective reinnervation of adult mammalian skeletal muscles. | in 2 rat muscles, serratus anterior and the diaphragm, the rostrocaudal axis of the motor pool is mapped onto the rostrocaudal axis of the muscle's surface (laskowski and sanes, 1987a). one possible basis for this orderly topography is that motor axons and intramuscular structures bear labels that favor connectivity among positionally matched partners. to test for the existence of such labels, we asked whether axons would selectively reinnervate appropriate portions of the muscles following nerv ... | 1988 | 3411370 |
| catalase-dependent ethanol oxidation in perfused rat liver. requirement for fatty-acid-stimulated h2o2 production by peroxisomes. | the purpose of this study was to measure rates of catalase-dependent ethanol uptake and rates of h2o2 generation in perfused rat livers in the presence of fatty acids of varying chain length. rates of ethanol uptake in livers from fasted rats, perfused in a recirculating system, of about 80 mumol g-1 h-1 were decreased to about 10 mumol g-1 h-1 by the addition of an inhibitor of alcohol dehydrogenase (adh), 4-methylpyrazole. the medium-chain-length fatty acid, laurate (12:0; 1 mm), increased rat ... | 1988 | 3416882 |
| the effects of heparin on the physicochemical properties of reconstituted collagen. | pepsin-solubilized bovine dermal collagen was reconstituted in 0.02 m sodium phosphate (ph 7.2), concentrated to 30-40 mg/ml, and adjusted to physiological ionic strength by addition of sodium chloride. these preparations, at 4-15 degrees c, are fibrillar suspensions composed of fibrils of varying diameters and nonassociated molecules. addition of heparin to these suspensions promoted a dose-dependent increase in average fibril diameter as measured by turbidimetry and electron microscopic analys ... | 1988 | 3126021 |
| [cerebrovascular incidents in 4 hemodialysis patients treated with erythropoietin]. | human recombinant erythropoietin (r-huepo) is very effective in the treatment of anemia of hemodialyzed patients. we describe 4 patients who developed symptoms of central nervous dysfunction during r-huepo therapy. three exhibited typical hypertensive encephalopathy, whereas signs of cerebral ischemia were found in the fourth. the increase in blood viscosity with r-huepo treatment, leading to a rise in peripheral vascular resistance and blood pressure especially in previously hypertensive patien ... | 1988 | 3187475 |
| low propensity for poultry isolates of pasteurella multocida to acquire adaptive resistance to oxytetracycline. | thirty independently derived reference strains and clinical isolates of pasteurella multocida were tested to determine their potential for acquiring adaptive resistance to oxytetracycline in an effort to better understand the prolonged high efficacy of the antibiotic for pasteurellosis in poultry. all reference strains and clinical isolates exhibited uniform susceptibility as measured with the broth dilution method. none of the strains or isolates readily acquired significant resistance when gro ... | 1988 | 3196263 |
| soft drug derivatives related to perhexiline. part ii: in vivo studies. | a series of cyclohexylaralkylamines derived from perhexiline and synthesized according to the "soft drug" concept were evaluated for haemodynamic effects and myocardial oxygen consumption in vivo. in anaesthetized rabbits, the most active compounds, 2, 5, and 11 decreased arterial blood pressure, to a greater extent dp/dtmax and, to a lesser extent heart rate. the decrease in cardiac work and the decrease in cardiac output varied concomitantly. the cardiac effort index decreased in all cases to ... | 1988 | 3196404 |
| temporal coding of resonances by low-frequency auditory nerve fibers: single-fiber responses and a population model. | 1. we recorded responses of low-frequency auditory nerve fibers (characteristic frequency (cf) less than 3 khz) in the cat to resonant stimuli with varied natural frequencies, damping coefficients, and sound pressure levels. responses to resonances were synchronized to frequencies lying between the peak frequency of the stimulus spectrum and a frequency near the fiber's cf. the frequency of the dominant synchrony in the response varied systematically as a function of the stimulus parameters. 2. ... | 1988 | 3199176 |
| ultrastructural identification of calbindin-d28k-immunoreactive cells in the rat superficial pineal body. | the vitamin-d-dependent calcium-binding protein, calbindin-d28k, was detected immunocytochemically in the majority of pericapillary pinealocytes of the rat superficial pineal body. the interstitial cells were calbindin-negative. the significance of these findings is discussed. | 1988 | 3213416 |
| [virus diseases of the nervous system in selected patients at a neurologic specialty unit during a 9-year period]. | during a 9-year period an unselected population of 377 patients with clinically suspected viral diseases of the nervous system were hospitalized. due to the serological findings a definite viral etiology could be established in 123 (33%). with respect to clinical syndromes serological evidence of viral etiology was found in 74% of mono- respectively oligoneuritides, 43% of meningoencephalitides, whereas in polyneuritis only in 18%. concerning different virus strains varicella zoster virus appear ... | 1988 | 3222963 |
| the cardiovascular effects of deconditioning after endurance training in rats. | the haemodynamic effects of endurance training and physical deconditioning were studied in anaesthetized rats using aortic and left ventricular pressure recordings and volume measurements by thermodilution method during isoproterenol and cacl2 loads. the resting stroke volume was significantly larger in the training group (tg i, n = 10) than in the control group (cg i, n = 13). during the cacl2 infusion stroke index, end-diastolic and end-systolic volumes increased in the tg i, but decreased in ... | 1988 | 3227925 |
| oxygen toxicity protecting enzymes in the human brain. | regional distribution of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities were studied in 22 anatomic sites of 5 human brains. no significant regional differences were observed in cytosolic activities of any enzyme studied, nor in particulate activities of superoxide dismutase, catalase and glutathione reductase, whereas particulate glutathione peroxidase activities were distributed unevenly, the highest activities observed in the basal nucleus and amy ... | 1988 | 3235996 |
| hypogammaglobulinemia and depressed natural killer cell cytotoxicity in a patient with pneumocystis carinii infection. | 1988 | 3263615 | |
| hepatitis b virus infection in children in taiwan. | 1988 | 3273357 | |
| effect of tidal volume and peep on rate of edema formation in in situ perfused canine lobes. | the effects of raising tidal volume and positive end-expiratory pressure (peep) on rate of edema formation were studied in in situ canine left upper lobe preparations. edema was induced by increasing blood flow to the left upper lobe (4-8 times normal). in the same animal, at equivalent flows and microvascular hydrostatic pressures, rate of edema formation observed with larger tidal volumes was significantly higher than that observed with smaller tidal volumes (0.73 +/- 0.29 vs. 0.58 +/- 0.30, p ... | 1988 | 3292503 |
| expression of glutathione s-transferase isoenzymes in human small cell lung cancer cell lines. | a glutathione s-transferase (gst) isoenzyme having common antigenicity to rat placental form (gst-p) and human placental form (gst-pi) has recently been suggested may be a marker of carcinogenesis. in the present study we have investigated the expression of this isoenzyme in three small cell lung cancer cell lines in order to determine whether or not this isoenzyme can be used as a general marker of carcinogenesis. gst activity towards 1-chloro-2,4-dinitrobenzene in two of the cell lines (nes an ... | 1988 | 2826036 |
| copy choice illegitimate dna recombination. | precise excision of tn10 and related transposons occurs by recombination between directly repeated 9 bp sequences that flank the transposon. the excision, which is a model for a class of illegitimate dna recombination events, was stimulated 10(6) times by induction of single-stranded dna synthesis, occurred during conversion of single-stranded dna to double-stranded form, and entailed no transfer of physical material from parental to progeny molecules. we conclude that it occurred by copy choice ... | 1988 | 2832066 |
| rapid diagnosis of bovine herpesvirus encephalitis: comparison of nucleic acid hybridization and immunoperoxidase methods using clinical samples. | 1988 | 2844043 | |
| in vitro motility of isolated adults and segments of onchocerca volvulus, brugia pahangi and acanthocheilonema viteae. | observations were made on the spontaneous motility in vitro of entire adult worms and segments of onchocerca volvulus, brugia pahangi and acanthocheilonema viteae. segment motility was recorded in a mechano-transducer apparatus and responses of worm tissues to anthelmintics and other pharmacological agents were compared. entire adult female o. volvulus showed varied patterns of motor activity, ranging from continuous low level whole body motion to periodic spasmodic contractions interspersed bet ... | 1988 | 2852396 |
| effect of a trypsin inhibitor from soybeans (bowman-birk) on the secretory activity of the human pancreas. | this study was undertaken to clarify the issue of whether feedback regulation of pancreatic enzyme secretion occurs in humans. a naturally occurring inhibitor of trypsin and chymotrypsin, the bowman-birk inhibitor of soybeans, was used to reduce the activities of these enzymes normally secreted by the pancreas into the duodenum. pure pancreatic juice was collected by endoscopic retrograde cannulation of the pancreatic duct in a protocol consisting of three periods: period 1 (15 min), collections ... | 1988 | 2446949 |
| enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding. | the stimulus specificity for enhancement of dynorphin gene expression in rat spinal cord was studied by combined measurements of the peptide dynorphin a 1-8 and preprodynorphin mrna levels during peripheral inflammation induced by several agents. the density of kappa receptors, the putative receptor for dynorphin peptides, was examined using receptor binding with autoradiographic visualization. mu and delta receptor classes were also studied. all inflammatory agents tested (carrageenan, phorbol ... | 1988 | 2906426 |
| identification of carbohydrate moieties involved in edta-stable or edta-sensitive cell contact of dictyostelium discoideum. | antisera against purified contact site a glycoprotein, with an apparent molecular weight of 80 x 10(3) (80 kda), from dictyostelium discoideum were raised by using freund's adjuvant (antiserum-a) and by using alu-gel-s (antiserum-b) as immunoadjuvants. they were converted into fab fragments for the cell agglutination assay. fab fragments of antiserum-b inhibited only edta-stable cell contact, whereas fab fragments of antiserum-a (fab-a) inhibited edta-sensitive cell contact as well as edta-stabl ... | 1987 | 3115971 |
| abnormalities of erythrocyte membrane fatty acid composition in human essential hypertension. | the fatty acid content of erythrocyte plasma membrane was estimated in cells of 17 untreated hypertensive patients, and compared to that of 16 control subjects matched for age, sex and weight. mean linoleic acid (18:2) content was significantly lower in hypertensives than controls, whereas arachidonic acid (20:4) and oleic acid (18:1) were significantly higher. these results provide further evidence for an alteration in the physiochemical structure of the plasma membrane in cells of hypertensive ... | 1987 | 3508198 |
| molecular hybridization versus isoelectric focusing to determine tem-type beta-lactamases in gram-negative bacteria. | isoelectric focusing and molecular hybridization with a tem dna probe were used to screen for tem beta-lactamase in 328 bacterial isolates representing 11 gram-negative genera. the tem enzyme was detected in 50% of isolates, and nine additional types of beta-lactamase could be identified in 36.9% of isolates. the tem gene was detected in 53.6% of isolates. the results obtained by both methods were concordant in 92.7% of the entire sample. in situ colony hybridization with a specific probe theref ... | 1987 | 3551834 |
| a novel yeast mutant defective in the processing of ras proteins: assessment of the effect of the mutation on processing steps. | biosynthesis of ras1 and ras2 proteins of saccharomyces cerevisiae involves processing, fatty acid acylation and transport to plasma membranes. we now report the isolation of a mutant, termed dpr1, defective in these biosynthetic events. the dpr1 cells are temperature sensitive for growth and display sterile phenotype specific to a cells. the following observations were made using cells overproducing the ras2 protein. (i) in the dpr1 cells, the ras2 proteins remain as precursors and accumulate i ... | 1987 | 3556161 |
| cimetidine and neonatal small bowel adaptation: an experimental study. | histamine2-blockers are being used more extensively in the pediatric short gut patient as an agent to accelerate small bowel adaptation. reversal of lipid malabsorption and a direct trophic effect on the intestinal crypt cells have been postulated as the mechanism for the salutary influence of cimetidine. weanling sprague-dawley rats underwent 85% small bowel resection. controls had repair of a simple ileal transection. rats received either a fat-defined rat chow only, or chow with high- or low- ... | 1987 | 3612436 |
| oxytocin and vasopressin immunoreactivity in hypothalamic and extrahypothalamic sites in late pregnant and postpartum rats. | this study examines immunoreactive levels of oxytocin (ot) and arginine-vasopressin (avp) from acid extracts of the paraventricular nucleus (pvn), supraoptic nucleus (son), anterior commissural nucleus (acn) and the suprachiasmatic nucleus (scn) as well as selected extrahypothalamic sites in pregnant or postpartum (pp) rats. animals are sacrificed between 08.30 and 10.30 h 16 or 22 days after sperm is detected in their vaginal smears or on the morning after parturition. peptide levels of pregnan ... | 1987 | 3614554 |
| effect of hyperthermia on the sensitivity of human colon carcinoma cells to mitoxantrone. | the effect of temperature on the cytotoxicity of mitoxantrone (mx) was investigated by exposing human widr colon carcinoma cells to elevated temperatures in the presence of drug. the survival of treated cells was determined by their ability to proliferate and to form colonies in vitro. it was demonstrated that incubation of widr cells with mx at 42 degrees c produced not only a higher toxicity but also a more rapid action than when cells were exposed to drug at 37 degrees c. by measuring the amo ... | 1987 | 3621216 |
| [human rights and nursing]. | 1987 | 3645762 | |
| synaptic organization of the nucleus raphe dorsalis of the cat. | this electron microscopic study describes the different types of synaptic terminals found in the nucleus raphe dorsalis of the adult cat. serial section analysis was used extensively to confirm the nature of the synaptic contact established by the various classes of terminals. five different classes of terminals are identified according to the shape and packing density of the synaptic vesicles and type of contact they establish. the most common class (rdi-type) contains densely packed, round, ag ... | 1987 | 3694237 |
| passive resistance of the human knee: the effect of remobilization. | changes of circumferential dimensions and passive resistance of the human knee caused by immobilization, were studied during remobilization. patients immobilized with a long leg cast after tibial fractures or ligamentous injuries were studied immediately after removal of the cast and after mean periods of 18, 36 and 81 days of remobilization. immobilization resulted in a decrease of circumferential dimensions. the difference in mid-thigh circumference between the immobilized and the unaffected l ... | 1987 | 3795907 |
| hydrophobic interactions of brush border alkaline phosphatases: the role of phosphatidyl inositol. | tissue-specific (intestinal) and tissue-nonspecific (kidney) rat alkaline phosphatases are released from their respective brush border membranes by different enzymes. to elucidate the mechanism underlying their membrane attachment, we tested the ability of these enzymes to partition into lipid or aqueous phases both before and after treatment with phospholipases and proteases. interaction with triton x-114 micelles was eliminated or decreased by treatment of intestinal enzyme with phospholipase ... | 1987 | 3813562 |
| human lipoprotein lipase complementary dna sequence. | lipoprotein lipase is a key enzyme of lipid metabolism that acts to hydrolyze triglycerides, providing free fatty acids for cells and affecting the maturation of circulating lipoproteins. it has been proposed that the enzyme plays a role in the development of obesity and atherosclerosis. the human enzyme has been difficult to purify and its protein sequence was heretofore undetermined. a complementary dna for human lipoprotein lipase that codes for a mature protein of 448 amino acids has now bee ... | 1987 | 3823907 |
| [electrical and contractile properties of the smooth muscle of the femoral artery in the rabbit]. | 1987 | 2446933 |