Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| isolation of trypanosomes in reference to the progress in microbiological purification techniques. | 2016 | 4722008 | |
| the use of laboratory animals. notes for the guidance of research workers. | 2016 | 4700674 | |
| the study of cells in cerebrospinal fluid by electron microscopy. a new method. | 2016 | 4898019 | |
| [granulomatous hepatitis in q fever]. | 2016 | 4840881 | |
| coxiella burnetii induces inflammatory interferon-like signature in plasmacytoid dendritic cells: a new feature of immune response in q fever. | plasmacytoid dendritic cells (pdcs) play a major role in antiviral immunity via the production of type i interferons (ifns). there is some evidence that pdcs interact with bacteria but it is not yet clear whether they are protective or contribute to bacterial pathogenicity. we wished to investigate whether coxiella burnetii, the agent of q fever, interacts with pdcs. the stimulation of pdcs with c. burnetii increased the expression of activation and migratory markers (cd86 and ccr7) as determine ... | 2016 | 27446817 |
| coxiella detection in ticks from wildlife and livestock in malaysia. | recent studies have shown that ticks harbor coxiella-like bacteria, which are potentially tick-specific endosymbionts. we recently described the detection of coxiella-like bacteria and possibly coxiella burnetii in ticks found from rural areas in malaysia. in the present study, we collected ticks, including haemaphysalis bispinosa, haemaphysalis hystricis, dermacentor compactus, dermacentor steini, and amblyomma sp. from wildlife and domesticated goats from four different locations in malaysia. ... | 2016 | 27763821 |
| hospital-based surveillance for infectious etiologies among patients with acute febrile illness in georgia, 2008-2011. | information on the infectious causes of undifferentiated acute febrile illness (afi) in georgia is essential for effective treatment and prevention. in may 2008, a hospital-based afi surveillance was initiated at six hospitals in georgia. patients aged ≥ 4 years with fever ≥ 38°c for ≥ 48 hours were eligible for surveillance. blood culture and serologic testing were conducted for leptospira spp., brucella spp., west nile virus (wnv), crimean-congo hemorrhagic fever virus, coxiella burnetii, tick ... | 2016 | 26438032 |
| prevalence and risk factors for campylobacter spp., salmonella spp., coxiella burnetii, and newcastle disease virus in feral pigeons (columba livia) in public areas of montreal, canada. | feral pigeons (columbia livia) can harbor a range of zoonotic pathogens. a transversal study was undertaken to estimate the prevalence of feral pigeons infected by various pathogens in public areas in montreal, quebec. cloacal swabs from captured birds were cultured for salmonella spp. and campylobacter spp. and tested by real-time polymerase chain reaction (rt-pcr) for the detection of coxiella burnetii. an oropharyngeal swab was also submitted to real-time reverse-transcription polymerase chai ... | 2016 | 26733736 |
| transcriptional profiling of coxiella burnetii reveals extensive cell wall remodeling in the small cell variant developmental form. | a hallmark of coxiella burnetii, the bacterial cause of human q fever, is a biphasic developmental cycle that generates biologically, ultrastructurally, and compositionally distinct large cell variant (lcv) and small cell variant (scv) forms. lcvs are replicating, exponential phase forms while scvs are non-replicating, stationary phase forms. the scv has several properties, such as a condensed nucleoid and an unusual cell envelope, suspected of conferring enhanced environmental stability. to ide ... | 2016 | 26909555 |
| absence of convincing evidence of coxiella burnetii infection in chile: a cross-sectional serosurvey among healthy adults in four different regions. | coxiella burnetii is an important zoonotic pathogen of global distribution. still, in most parts of south america including chile, systematic epidemiological data are lacking. the presented study aims to determine the seroprevalence of coxiella burnetii antibodies in healthy adults of four different regions in chile. | 2016 | 27716089 |
| a francisella-like endosymbiont in the gulf coast tick evolved from a mammalian pathogen. | ticks (order ixodida) vector pathogenic bacteria that cause diseases in humans and other mammals. they also contain bacteria that are closely related to pathogens but function as endosymbionts that provide nutrients that are missing from mammalian blood-their sole food source. for instance, mammalian pathogens such as coxiella burnetii and francisella tularensis, as well as coxiella-like and francisella-like endosymbionts (cles and fles, respectively) occur in ticks worldwide. however, it is not ... | 2016 | 27645766 |
| development of liposomal ciprofloxacin to treat lung infections. | except for management of pseudomonas aeruginosa (pa) in cystic fibrosis, there are no approved inhaled antibiotic treatments for any other diseases or for infections from other pathogenic microorganisms such as tuberculosis, non-tuberculous mycobacteria, fungal infections or potential inhaled biowarfare agents including francisella tularensis, yersinia pestis and coxiella burnetii (which cause pneumonic tularemia, plague and q fever, respectively). delivery of an antibiotic formulation via the i ... | 2016 | 26938551 |
| candidatus coxiella massiliensis infection. | bacteria genetically related to coxiella burnetii have been found in ticks. using molecular techniques, we detected coxiella-like bacteria, here named candidatus coxiella massiliensis, in skin biopsy samples and ticks removed from patients with an eschar. this organism may be a common agent of scalp eschar and neck lymphadenopathy after tick bite. | 2016 | 26811945 |
| the intervening sequence of coxiella burnetii: characterization and evolution. | the intervening sequence (ivs) of coxiella burnetii, the agent of q fever, is a 428-nt selfish genetic element located in helix 45 of the precursor 23s rrna. the ivs element, in turn, contains an orf that encodes a hypothetical ribosomal s23 protein (s23p). although s23p can be synthesized in vitro in the presence of an engineered e. coli promoter and ribosome binding site, results suggest that the protein is not synthesized in vivo. in spite of a high degree of ivs conservation among different ... | 2016 | 27595093 |
| analysis of the caenorhabditis elegans innate immune response to coxiella burnetii. | the nematode caenorhabditis elegans is well established as a system for characterization and discovery of molecular mechanisms mediating microbe-specific inducible innate immune responses to human pathogens. coxiella burnetii is an obligate intracellular bacterium that causes a flu-like syndrome in humans (q fever), as well as abortions in domesticated livestock, worldwide. initially, when wild type c. elegans (n2 strain) was exposed to mcherry-expressing c. burnetii (ccb) a number of overt path ... | 2016 | 27884946 |
| effector protein cig2 decreases host tolerance of infection by directing constitutive fusion of autophagosomes with the coxiella-containing vacuole. | coxiella burnetii replicates in an acidified lysosome-derived vacuole. biogenesis of the coxiella-containing vacuole (ccv) requires bacterial effector proteins delivered into host cells by the dot/icm secretion system. genetic and cell biological analysis revealed that an effector protein called cig2 promotes constitutive fusion of autophagosomes with the ccv to maintain this compartment in an autolysosomal stage of maturation. this distinguishes the ccv from other pathogen-containing vacuoles t ... | 2016 | 27435465 |
| atypical aetiology in patients hospitalised with community-acquired pneumonia is associated with age, gender and season; a data-analysis on four dutch cohorts. | microorganisms causing community-acquired pneumonia (cap) can be categorised into viral, typical and atypical (legionella species, coxiella burnetii, mycoplasma pneumoniae, and chlamydia species). extensive microbiological testing to identify the causative microorganism is not standardly recommended, and empiric treatment does not always cover atypical pathogens. in order to optimize epidemiologic knowledge of cap and to improve empiric antibiotic choice, we investigated whether atypical microor ... | 2016 | 27317257 |
| coxiella burnetii effector cvpb modulates phosphoinositide metabolism for optimal vacuole development. | the q fever bacterium coxiella burnetii replicates inside host cells within a large coxiella-containing vacuole (ccv) whose biogenesis relies on the dot/icm-dependent secretion of bacterial effectors. several membrane trafficking pathways contribute membranes, proteins, and lipids for ccv biogenesis. these include the endocytic and autophagy pathways, which are characterized by phosphatidylinositol 3-phosphate [pi(3)p]-positive membranes. here we show that the c. burnetii secreted effector coxie ... | 2016 | 27226300 |
| type i interferon counters or promotes coxiella burnetii replication dependent on tissue. | coxiella burnetii is an intracellular pathogen and the cause of q fever. gamma interferon (ifn-γ) is critical for host protection from infection, but a role for type i ifn in c. burnetii infection has not been determined. type i ifn supports host protection from a related pathogen, legionella pneumophila, and we hypothesized that it would be similarly protective in c. burnetii infection. in contrast to our prediction, ifn-α receptor-deficient (ifnar(-/-)) mice were protected from c. burnetii-ind ... | 2016 | 27068091 |
| complementation of arginine auxotrophy for genetic transformation of coxiella burnetii by use of a defined axenic medium. | host cell-free (axenic) culture of coxiella burnetii in acidified citrate cysteine medium-2 (accm-2) has provided important opportunities for investigating the biology of this naturally obligate intracellular pathogen and enabled the development of tools for genetic manipulation. however, accm-2 has complex nutrient sources that preclude a detailed study of nutritional factors required for c. burnetii growth. metabolic reconstruction of c. burnetii predicts that the bacterium cannot synthesize a ... | 2016 | 26969695 |
| development of an ex vivo tissue platform to study the human lung response to coxiella burnetii. | coxiella burnetii is an intracellular bacterial pathogen that causes human q fever, an acute debilitating flu-like illness that can also present as chronic endocarditis. disease typically occurs following inhalation of contaminated aerosols, resulting in an initial pulmonary infection. in human cells, c. burnetii generates a replication niche termed the parasitophorous vacuole (pv) by directing fusion with autophagosomes and lysosomes. c. burnetii requires this lysosomal environment for replicat ... | 2016 | 26902725 |
| disease burden of 32 infectious diseases in the netherlands, 2007-2011. | infectious disease burden estimates provided by a composite health measure give a balanced view of the true impact of a disease on a population, allowing the relative impact of diseases that differ in severity and mortality to be monitored over time. this article presents the first national disease burden estimates for a comprehensive set of 32 infectious diseases in the netherlands. | 2016 | 27097024 |
| coxiella burnetii dormancy in a fatal ten-year multisystem dysfunctional illness: case report. | in a previous study of a q fever outbreak in birmingham, our group identified a non-infective complex of coxiella burnetii (c.b.) antigens able to survive in the host and provoked aberrant humoral and cell-mediated immunity responses. the study led to recognition of a possible pathogenic link between c.b. infection and subsequent long-term post q fever fatigue syndrome (qfs). this report presents an unusually severe case of c.b. antigen and dna detection in post-mortem specimens from a patient w ... | 2016 | 27091026 |
| primary role for toll-like receptor-driven tumor necrosis factor rather than cytosolic immune detection in restricting coxiella burnetii phase ii replication within mouse macrophages. | coxiella burnetii replicates within permissive host cells by employing a dot/icm type iv secretion system (t4ss) to translocate effector proteins that direct the formation of a parasitophorous vacuole. c57bl/6 mouse macrophages restrict the intracellular replication of the c. burnetii. nine mile phase ii (nmii) strain. however, eliminating toll-like receptor 2 (tlr2) permits bacterial replication, indicating that the restriction of bacterial replication is immune mediated. here, we examined whet ... | 2016 | 26787725 |
| studying coxiella burnetii type iv substrates in the yeast saccharomyces cerevisiae: focus on subcellular localization and protein aggregation. | coxiella burnetii is a gram-negative obligate parasitic bacterium that causes the disease q-fever in humans. to establish its intracellular niche, it utilizes the icm/dot type ivb secretion system (t4bss) to inject protein effectors into the host cell cytoplasm. the host targets of most cognate and candidate t4bss-translocated effectors remain obscure. we used the yeast saccharomyces cerevisiae as a model to express and study six c. burnetii effectors, namely anka, ankb, ankf, cbu0077, caea and ... | 2016 | 26821324 |
| [in memoriam prof. behrend behrens, m.d., 23 may 1895--30 december 1969]. | 2016 | 4923644 | |
| [active geriatrics. a visit to rotterdam]. | 2016 | 4706650 | |
| [seamen's professional ocular diseases]. | 2016 | 5103241 | |
| [unevenness of ureter opacification in timed urography as a sign of reno-vascular hypertension]. | 2016 | 5053978 | |
| we can find ways to care for indigents. | 2016 | 5025582 | |
| nobel error. | 2016 | 5029230 | |
| [benzo(a)pyrene in polluted air]. | 2016 | 5085011 | |
| [nutrition of a patient with surgery of the digestive system]. | 2016 | 5000648 | |
| [mycosis of the central nervous system in blastomatous reticulosis]. | 2016 | 4921463 | |
| does prayer preserve? | 2016 | 4908759 | |
| [selection of the optimal regime of controlled breathing for patients who have undergone surgery in the trendelenburg position]. | 2016 | 4888597 | |
| [surgical management without sphincterectomy of anorectal fistulas in the anterior hemi-circumference]. | 2016 | 4887016 | |
| [neonatal tetany]. | 2016 | 4857413 | |
| the release of acetylcholine (ach) by the crossed olivo-cochlear bundle (cocb). | 2016 | 4835631 | |
| the principle of the 'aérosol sonique'. | 2016 | 4795628 | |
| [familial infections with candida]. | 2016 | 4726626 | |
| [contractile function of the myocardium in patients with the hypertensive form of glomerulonephritis]. | 2016 | 5017214 | |
| howard douglas fabing. feb. 21, 1907-july 29, 1970. | 2016 | 4934770 | |
| [3 hereditary growth disorders]. | 2016 | 5013579 | |
| unconscious versus potential affects. | 2016 | 4814472 | |
| [early blood coagulation disorders following open heart surgery]. | 2016 | 4686038 | |
| gastrografin as a therapeutic agent in stomal malfunction after gastric resection. | 2016 | 5079790 | |
| medicine takers. | 2016 | 4766238 | |
| mitochondria and cellular activity. | 2016 | 4893716 | |
| [proceedings: symptoms, diagnostic measures and treatment of thyroid carcinoma (author's transl)]. | 2016 | 4776121 | |
| physiopathological observations on the mechanism of stimulus sensitive myoclonus. a stereotactic study. | 2016 | 5084392 | |
| distortion produced by pinhole collimators. | 2016 | 5056700 | |
| [cellular and vascular elements and the connective tissue reaction in inflammation]. | 2016 | 5028885 | |
| [clinical experimentation with a new anti-hypertensive agent (st 155)]. | 2016 | 5025774 | |
| hysteria: in search of the animus. | 2016 | 4930937 | |
| [clinical aspects and therapy of uterine ruptures]. | 2016 | 4805265 | |
| treatment of advanced epithelial downgrowth. | 2016 | 4784905 | |
| letter: radioassay for serum folate. | 2016 | 4810082 | |
| [present forensic dentistry, from early times to today]. | 2016 | 4898140 | |
| [neonatal jaundice due to hepatic immaturity. physiopathology and treatment. role of enzyme inductors]. | 2016 | 5089129 | |
| [children with chronic non-specific lung disease and their birth dates]. | 2016 | 4831477 | |
| dosimetric properties of neutron beams produced by 16-60 mev deuterons on beryllium. | 2016 | 4699794 | |
| pancreatic grafts and diabetes. | 2016 | 4863248 | |
| quantitative histochemistry of the primate skin. v. glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. | 2016 | 4958265 | |
| aortic arch anomalies. | 2016 | 4920081 | |
| correlative assessment of the macroalbumin lung scan with the clinical and roentgenographic chest findings. | 2016 | 4951447 | |
| fixation of sea urchin eggs. an improved technique for the study of ultrastructure. | 2016 | 4862715 | |
| metastatic hemangiopericytoma cured by radiotherapy. a case report. | 2016 | 4835832 | |
| rupture of the right hemidiaphragm due to blunt trauma. | 2016 | 4951175 | |
| a comparison of combantrin with antepar and alcopar in helminthiasis in school children in lagos, nigeria. | 2016 | 4807492 | |
| the venous system of the corpus striatum. angiographic study. | 2016 | 4772447 | |
| current status of insulin in the treatment of diabetes mellitus. | 2016 | 4759071 | |
| [application of fluorescent angiography and angioscopy of the fundus oculi in neurology]. | 2016 | 5050043 | |
| obturator hernia. | 2016 | 5037804 | |
| yolk sac tumor associated with seminoma of the testis in adults. | 2016 | 4823489 | |
| clinical applications of brain blood flow studies. | 2016 | 4938393 | |
| the old private lunatic asylum at fishponds. | 2016 | 4915168 | |
| the occurrence of spina bifida cystica in south australia. | 2016 | 4861507 | |
| [studies on the effect of sulfamethoxypyrazine (longum) on carbohydrate metabolism in diabetic patients]. | 2016 | 4822858 | |
| [method of studying the electroretinogram of children in a state of hypnosis]. | 2016 | 4754090 | |
| manic psychosis in connection with q-fever. | 2016 | 4825660 | |
| evolution of the medical director concept. | 2016 | 4808782 | |
| collagen synthesis in keloid and hypertrophic scar following intralesional use of triamcinolone. | 2015 | 4377040 | |
| [preprosthetic surgery]. | 2015 | 4593428 | |
| [genetics of flash-nod-salaam seizures based on anamnestic examinations and electroencephalographic investigations of the family]. | 2015 | 4629997 | |
| chronic lymphedema of the scrotum and penis. | 2015 | 4527701 | |
| [acute inflammation of the maxillary sinuses with atypical symptoms simulating palatal abscess]. | 2015 | 4528133 | |
| hypertension and heart disease in the urban community. | 2015 | 4513125 | |
| [study of proteolytic activity in q fever]. | 2015 | 4646612 | |
| effects of alcohol, uncertainty and novelty upon response selection. | 2015 | 4427992 | |
| [effect of methoxyflurane on the cardiovascular system]. | 2015 | 4409375 | |
| history of the community psychiatry movement. | 2015 | 4894789 | |
| chemical modification of ehrlich ascites tumour cells by periodate and succinic anhydride: effects on metabolism and membrane permeability. | 2015 | 4355314 | |
| thrombotic thrombocytopenic purpura. recovery after splenectomy. | 2015 | 4285278 | |
| [3 new species of trombiculidae (acarina) from senegal]. | 2015 | 4668051 | |
| a proposal worthy of the support of every filipino nurse. | 2015 | 4488386 | |
| a study of services and needs of teenage pregnant girls in the large cities of the united states. | 2015 | 4682630 | |
| the development of the lower uterine segment. | 2015 | 4511745 | |
| [inter-individual differences in pharmacokinetics in humans: clinical importance]. | 2015 | 4703858 | |
| fluorescein angiography of the choroidal circulation. | 2015 | 4657179 |