Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| identification of the rna pyrophosphohydrolase rpph of helicobacter pylori and global analysis of its rna targets. | rna degradation is crucial for regulating gene expression in all organisms. like the decapping of eukaryotic mrnas, the conversion of the 5'-terminal triphosphate of bacterial transcripts to a monophosphate can trigger rna decay by exposing the transcript to attack by 5'-monophosphate-dependent ribonucleases. in both biological realms, this deprotection step is catalyzed by members of the nudix hydrolase family. the genome of the gastric pathogen helicobacter pylori, a gram-negative epsilonprote ... | 2017 | 27974459 |
| bismuth-based quadruple therapy modified with moxifloxacin for helicobacter pylori eradication. | the aim of this study was to evaluate the efficacy, tolerability and safety of modified bismuth-based quadruple therapy for the second-line eradication treatment of helicobacter pylori (h. pylori) infection. | 2017 | 27973462 |
| conversion of an open salmon's technique to a laparoscopic gastric bypass. | there are a growing number of patients who require revisional bariatric surgery due to the failure of their primary procedures. the aim of this video is to present a laparoscopic revisional procedure for dysphagia and gastroesophageal reflux disease (gerd) after an uncommonly performed bariatric surgery, salmon's technique, consisting of a vertical banded gastroplasty and a horizontal stomach stapling with a roux-en-y bypass. | 2017 | 27966065 |
| characterization of gastric microbiota in twins. | contribution of host genetic backgrounds in the development of gastric microbiota has not been clearly defined. this study was aimed to characterize the biodiversity, structure and composition of gastric microbiota among twins. a total of four pairs of twins and eight unrelated individuals were enrolled in the study. antral biopsies were obtained during endoscopy. the bacterial 16s rrna gene was amplified and pyrosequenced. sequences were analyzed for the composition, structure, and α and β dive ... | 2017 | 27957630 |
| treatment of helicobacter pylori infected mice with bryophyllum pinnatum, a medicinal plant with antioxidant and antimicrobial properties, reduces bacterial load. | bryophyllum pinnatum (lam.) kurz (crassulaceae) is a plant known for its antiulcer properties. | 2017 | 27937097 |
| thrombocytopenia and infections. | acquired thrombocytopenia recognizes a myriad of causes. among these, infectious diseases play a relevant role since a low platelet count is commonplace along with other abnormal laboratory data. areas covered: this narrative review, after a brief presentation of the possible pathogenic mechanisms, is focused on the most prevalent infections associated with thrombocytopenia, namely those attributable to hepatitis c virus (hcv), human immunodeficiency virus (hiv) and helicobacter pylori. expert c ... | 2017 | 27936979 |
| ccr2 mediates helicobacter pylori-induced immune tolerance and contributes to mucosal homeostasis. | we previously demonstrated that h. pylori infection leads to increased induction of regulatory t cells in local and systemic immune compartments. here, we investigate the role of ccr2 in the tolerogenic programing of dendritic cells in a mouse model of h. pylori infection. | 2017 | 27933701 |
| racial and ethnic minorities at increased risk for gastric cancer in a regional us population study. | limited data are available on risk factors for gastric cancer in the united states. we aimed to characterize risk for gastric cancer based on race/ethnicity and additional established risk factors. | 2017 | 27939654 |
| effect of abdominal visceral fat on the development of new erosive oesophagitis: a prospective cohort study. | although abdominal visceral fat has been associated with erosive oesophagitis in cross-sectional studies, there are no data that describe its longitudinal effects. we aimed to evaluate the longitudinal effects of abdominal visceral fat on the development of new erosive oesophagitis in patients who did not have erosive oesophagitis at baseline. | 2017 | 27922485 |
| s2k-guideline helicobacter pylori and gastroduodenal ulcer disease. | 2017 | 27919112 | |
| common challenges in studying the structure and function of bacterial proteins: case studies from helicobacter pylori. | employing biophysical and structural methods is a powerful way to elucidate mechanisms of molecular recognition in bacterial pathogenesis. such studies invariably depend on the production of pure, folded and stable proteins. many proteins that can be expressed recombinantly ultimately fail to meet one or more of these criteria. the cag proteins from helicobacter pylori form a secretion system that delivers the oncoprotein, caga, into human gastric epithelial cells through an interaction between ... | 2017 | 27914074 |
| competition for iron between host and pathogen: a structural case study on helicobacter pylori. | helicobacter pylori (h. pylori) is a highly successful bacterial pathogen, which colonizes the stomach of more than half of the world's population. to colonize and survive in such an acidic and inhospitable niche, h. pylori cells have evolved complex mechanisms to acquire nutrients from human hosts, including iron, an essential nutrient for both the pathogens and host cells. however, human cells also utilize diverse strategies in withholding of irons to prevent the bacterial outgrowth. the compe ... | 2017 | 27914073 |
| inflammatory signaling pathways induced by helicobacter pylori in primary human gastric epithelial cells. | inflammatory signaling pathways induced by helicobacter pylori remain unclear, having been studied mostly on cell-line models derived from gastric adenocarcinoma with potentially altered signaling pathways and nonfunctional receptors. here, h. pylori-induced signaling pathways were investigated in primary human gastric epithelial cells. inflammatory response was analyzed on chemokine mrna expression and production after infection of gastric epithelial cells by h. pylori strains, b128 and b128δ c ... | 2017 | 27913793 |
| bismuth and non-bismuth quadruple therapy for helicobacter pylori eradication: time to make the switch in clinical practice? | 2017 | 27899016 | |
| the toronto helicobacter pylori consensus in context. | 2017 | 27899015 | |
| alcohol and cancer-individual risk factors. | 2017 | 27905157 | |
| medication adherence pattern and factors affecting adherence in helicobacter pylori eradication therapy. | background helicobacter pylori (h. pylori) infection is the most common chronic bacterial infection worldwide affecting approximately half of the world's population. a number of screening tests as well as complex multi-drug therapies are available for the detection and treatment of h. pylori infection. however, the optimum eradication rates of h. pylori infection can only be achieved if adherence to drug therapy is higher. therefore, it is of utmost importance to determine the factors leading to ... | 2017 | 27892443 |
| current treatment of helicobacter pylori infection. | 2017 | 27916266 | |
| selective staining of gastric biopsies for h. pylori does not affect detection rates or turnaround time and improves cost compared to reflexive staining. | to evaluate how reflexive versus selective h. pylori stains affect detection rates, turnaround time (tat), and cost savings in a real life practice environment following an institutional policy change. | 2017 | 27914768 |
| biofilm formation enhances helicobacter pylori survivability in vegetables. | to date, the exact route and mode of transmission of helicobacter pylori remains elusive. the detection of h. pylori in food using molecular approaches has led us to postulate that the gastric pathogen may survive in the extragastric environment for an extended period. in this study, we show that h. pylori prolongs its survival by forming biofilm and micro-colonies on vegetables. the biofilm forming capability of h. pylori is both strain and vegetable dependent. h. pylori strains were classified ... | 2017 | 27889168 |
| cardio-cerebrovascular disease and helicobacter pylori-related metabolic syndrome: we consider eradication therapy as a potential cardio-cerebrovascular prevention strategy. | 2017 | 27887801 | |
| the b-cell-activating factor signalling pathway is associated with helicobacter pylori independence in gastric mucosa-associated lymphoid tissue lymphoma without t(11;18)(q21;q21). | we previously reported that activation of the b-cell-activating factor (baff) pathway upregulates nuclear factor-κb (nf-κb) and induces bcl3 and bcl10 nuclear translocation in helicobacter pylori (hp)-independent gastric diffuse large b-cell lymphoma (dlbcl) tumours with evidence of mucosa-associated lymphoid tissue (malt). however, the significance of baff expression in hp independence of gastric low-grade malt lymphomas without t(11;18)(q21;q21) remains unexplored. sixty-four patients who unde ... | 2017 | 27873317 |
| high antibiotic resistance of helicobacter pylori and its effect on tailored and empiric eradication of the organism in lower silesia, poland. | at present, the resistance to antibiotics is considered the most important reason for helicobacter pylori (hp) eradication failure. the aim of this study was to estimate the prevalence of antimicrobial resistance of hp strains and to evaluate tailored and empiric therapeutic regimens in patients with peptic ulcer disease associated with infection of this microorganism. | 2017 | 27879042 |
| oral helicobacter pylori vaccine-encapsulated acid-resistant hp55/plga nanoparticles promote immune protection. | oral vaccination, is notoriously weak or nonimmunogenic. one of the major reasons is the inefficient antigen uptake caused by enzymolysis and hydrolysis in the gastrointestinal tract. in this study, acid-resistant hp55/plga nanoparticle was developed as an oral delivery system to protect h. pylori recombinant antigen ccf against the complex gastrointestinal environment. these ∼200nm particles controlled the release of antigen in the acidic environment (ph⩽5.5). immunized mice with hp55/plga-ccf ... | 2017 | 27865932 |
| the influence of helicobacter pylori on the ethnic distribution of barrett's metaplasia. | environmental risk factors associated with ethnicity may contribute to the occurrence of barrett's metaplasia. | 2017 | 27862104 |
| expressions of the caga protein and caga-signaling molecules predict helicobacter pylori dependence of early-stage gastric dlbcl. | we previously reported that early-stage gastric diffuse large b-cell lymphomas (dlbcls), including dlbcls with mucosa-associated lymphoid tissue (dlbcl[malt]) and without ("pure" dlbcl) the features of malt lymphomas, can achieve long-term complete remission after frontline helicobacter pylori (hp) eradication (hpe). we recently reported that expression of cytotoxin-associated gene a (caga) and caga-signaling molecules (phospho-src homology-2 domain-containing phosphatase [p-shp2] and phospho-ex ... | 2017 | 27864293 |
| detection of helicobacter pylori and the genotypes of resistance to clarithromycin and the heterogeneous genotype to this antibiotic in biopsies obtained from symptomatic children. | the aim of this study was to use a commercially available kit (genotype® helicodr; hain life science, germany) to detect helicobacter pylori infection and clarithromycin resistance genotype in biopsies obtained from symptomatic children. | 2017 | 27863951 |
| left ventricular assist devices and gastrointestinal evaluation: results of a consecutive case series. | to evaluate the benefit of preoperative gastrointestinal endoscopic evaluation in patients undergoing continuous flow left ventricular assist devices (cf-lvads) implantation. | 2017 | 27863356 |
| antiphospholipid syndrome, preeclampsia, and infection by helicobacter pylori. | 2017 | 27862565 | |
| helicobacter pylori infection modulates the expression of mirnas associated with dna mismatch repair pathway. | genetic and epigenetic inactivation of dna mismatch repair (mmr) genes might lead to modifications in cancer-related gene expression and cancer development. recently, it has been shown that the infection by helicobacter pylori, the major causative agent of gastric cancer, induces dna damage and inhibits mmr dna repair. also, it has been reported that micrornas (mirs) have an important role in regulating genomic stability and mmr dna repair. thus, the aim of this study was to identify mirs regula ... | 2017 | 27862371 |
| diagnostic accuracy of the (14)c-urea breath test in helicobacter pylori infections: a meta-analysis. | to summarize and appraise the available literature regarding the use of the (14)c-urea breath test in the diagnosis of helicobacter pylori infections in adult patients with dyspepsia and to calculate pooled diagnostic accuracy measures. | 2017 | 27848071 |
| addition of cranberry to proton pump inhibitor-based triple therapy for helicobacter pylori eradication. | proton pump inhibitor-based triple therapy with two antibiotics for helicobacter pylori eradication is widely accepted, but this combination fails in a considerable number of cases. some studies have shown that cranberry inhibits the adhesion of a wide range of microbial pathogens, including h. pylori. the aim of this study was to assess the effect of cranberry on h. pylori eradication with a standard therapy including lansoprazole, clarithromycin, and amoxicillin (lca) in patients with peptic u ... | 2017 | 27843960 |
| protection of mice against gastric colonization of helicobacter pylori by therapeutic immunization with systemic whole cell inactivated vaccines. | the protective effect of therapeutic immunization with heat inactivated helicobacter pylori cells administered with aluminum phosphate as an adjuvant was evaluated with "swiss albino mice" infected with h. pylori sydney strain 1 (ss1). the presence of bacteria in histological sections of the stomach was evaluated to confirm the colonization of h. pylori. the infection dose was determined to be 1 × 10(8) cells which resulted to be the optimal concentration to sustain infection for required time. ... | 2017 | 27843062 |
| dynamic changes in helicobacter pylori status following gastric cancer surgery. | helicobacter pylori eradication is recommended in patients with early gastric cancer. however, the possibility of spontaneous regression raises a question for clinicians about the need for "retesting" postoperative h. pylori status. | 2017 | 27840366 |
| effects of helicobacter pylori eradication on insulin resistance and metabolic parameters: a systematic review and meta-analysis. | previous studies have shown a close relationship between helicobacter pylori (h. pylori), insulin resistance, and altered metabolic parameters. however, the effects of h. pylori eradication on these conditions remain controversial. we carried out a systematic review and meta-analysis to evaluate the effects of h. pylori eradication on insulin resistance and metabolic parameters. | 2017 | 27832037 |
| integration of fluorescence imaging with proteomics enables visualization and identification of metallo-proteomes in living cells. | metalloproteins account for nearly one-third of proteins in proteomes. to date, the identification of metalloproteins relies mainly on protein purification and the subsequent characterization of bound metals, which often leads to losses of metal ions bound weakly and transiently. herein, we developed a strategy to visualize and subsequently identify endogenous metalloproteins and metal-binding proteins in living cells via integration of fluorescence imaging with proteomics. we synthesized a "met ... | 2017 | 27830853 |
| risk factors for intestinal metaplasia in a southeastern chinese population: an analysis of 28,745 cases. | to identify risk factors for intestinal metaplasia in a southeastern chinese population. | 2017 | 27832356 |
| role of probiotics in managing of helicobacter pylori infection: a review. | background:helicobacter pylori is a prevalent pathogen which is considered as an etiological cause for gastroduodenal ulcers, and a substantial risk factor for gastric malignancies. the vital factor to take into account is that roughly half of the world's population is infected with this bacterium. however, most subjects colonized remain asymptomatic and do not require any treatment. several antimicrobial agents such as amoxicillin, clarithromycin and metronidazole are used to eradicate the infe ... | 2017 | 27824431 |
| regression of gastric de novo diffuse large b-cell lymphoma following helicobacter pylori eradication: a case report. | we report a case of primary gastric diffuse large b-cell lymphoma (dlbcl), de novo dlbcl without the features of mucosa-associated lymphoid tissue (malt) lymphoma, which regressed after helicobacter pylori (hp) eradication. a 27-year-old japanese female with epigastralgia was revealed to have ulcerated lesions in the angle and antral regions on gastroscopy. biopsy specimen was consistent with a diagnosis of dlbcl without malt lymphoma component, indicating de novo development. her clinical stagi ... | 2017 | 27821034 |
| does helicobacter pylori eradication therapy trigger or protect against crohn's disease? | helicobacter pylori (h. pylori) infection is involved in multiple gastrointestinal and extra-gastrointestinal disorders. this review focuses on possible link between h. pylori eradication and crohn's disease (cd) which is a chronic inflammatory bowel disease (ibd). fecal calprotectin and; to lesser extent; fecal lactoferrin are sensitive and specific markers for monitoring cd activity. data about link between h. pylori eradication and cd are limited and inconclusive. the infection likely shifts ... | 2017 | 27821031 |
| characterization of the gastric microbiota in a pediatric population according to helicobacter pylori status. | helicobacter pylori colonizes the human stomach of approximately 50% of the world's population, and increases the risk of several gastric diseases. the goal of this study is to compare the gastric microbiota in pediatric patients with and without h. pylori colonization. | 2017 | 27820723 |
| clinical impact of colonoscopy for patients with early gastric cancer treated by endoscopic submucosal dissection: a matched case-control study. | gastric cancer frequently occurs synchronously with colorectal cancer (crc). | 2017 | 27810400 |
| analysis of the cost-effectiveness of using vonoprazan-amoxicillin-clarithromycin triple therapy for first-line helicobacter pylori eradication. | vonoprazan (vpz)-based triple therapy has been reported to have greater efficacy than a proton pump inhibitor (ppi)-based triple therapy for helicobacter pylori (h. pylori) eradication. however, because vpz is more expensive than ppis such as rabeprazole (rpz), economic evaluation is essential. | 2017 | 27806639 |
| the role of helicobacter pylori in laryngopharyngeal reflux. | objective the primary objective was to determine the prevalence of helicobacter pylori among patients with laryngopharyngeal reflux. the secondary objective was determining if h pylori eradication leads to greater symptom improvement in patients with laryngopharyngeal reflux as compared with standard proton pump inhibitor therapy alone. data sources embase, cumulative index to nursing and allied health literature, medline, world health organization international clinical trials registry platform ... | 2017 | 27803078 |
| quantum changes in helicobacter pylori gene expression accompany host-adaptation. | helicobacter pylori is a highly successful gastric pathogen. high genomic plasticity allows its adaptation to changing host environments. complete genomes of h. pylori clinical isolate um032 and its mice-adapted serial derivatives 298 and 299, generated using both pacbio rs and illumina miseq sequencing technologies, were compared to identify novel elements responsible for host-adaptation. the acquisition of a jhp0562-like allele, which encodes for a galactosyltransferase, was identified in the ... | 2017 | 27803027 |
| management of helicobacter pylori infection-the maastricht v/florence consensus report. | important progress has been made in the management of helicobacter pylori infection and in this fifth edition of the maastricht consensus report, key aspects related to the clinical role of h. pylori were re-evaluated in 2015. in the maastricht v/florence consensus conference, 43 experts from 24 countries examined new data related to h. pylori in five subdivided workshops: (1) indications/associations, (2) diagnosis, (3) treatment, (4) prevention/public health, (5) h. pylori and the gastric micr ... | 2017 | 27707777 |
| the helicobacter pylori autotransporter imaa tempers the bacterium's interaction with α5β1 integrin. | the human pathogen helicobacter pylori uses the host receptor α5β1 integrin to trigger inflammation in host cells via its cag pathogenicity island (cag pai) type iv secretion system (t4ss). here, we report that the h. pylori imaa protein (hp0289) decreases the action of the cag pai t4ss via tempering the bacterium's interaction with α5β1 integrin. previously, imaa-null mutants were found to induce an elevated inflammatory response that was dependent on the cag pai t4ss; here we extend those find ... | 2017 | 27795352 |
| nf-κb mediated transcription of darpp-32 prevents helicobacter pylori-induced cell death. | 2017 | 27789656 | |
| fruit and vegetable consumption, helicobacter pylori antibodies, and gastric cancer risk: a pooled analysis of prospective studies in china, japan, and korea. | epidemiological findings on the association between fruit and vegetable consumption and gastric cancer risk remain inconsistent. the present analysis included 810 prospectively ascertained non-cardia gastric cancer cases and 1,160 matched controls from the helicobacter pylori biomarker cohort consortium, which collected blood samples, demographic, lifestyle, and dietary data at baseline. conditional logistic regression adjusting for total energy intake, smoking, and h. pylori status, was applied ... | 2017 | 27759938 |
| rosacea and gastrointestinal disorders: a population-based cohort study. | rosacea is a common inflammatory facial skin condition. recent genetic and epidemiological studies have suggested pathogenic links between rosacea and gastrointestinal disorders, but data are limited. | 2017 | 27501017 |
| effects of genetic polymorphisms of cytochrome p450 enzymes and mdr1 transporter on pantoprazole metabolism and helicobacter pylori eradication. | pantoprazole is a proton pump inhibitor that is commonly used in the treatment of peptic ulcer disease (pud) and metabolized by cytochrome p450 (cyp) enzymes cyp2c19 and cyp3a4. pantoprazole is a substrate for multi-drug resistance protein 1 (mdr1). single nucleotide polymorphisms (snps) in cyp2c19, cyp3a4 and mdr1 affect enzyme activity or gene expression of proteins and may alter plasma pantoprazole concentrations and treatment success in pud. in this study, we aimed to investigate the associa ... | 2017 | 27611887 |
| trends in gastric and esophageal cancer incidence in northern portugal (1994-2009) by subsite and histology, and predictions for 2015. | gastric cancer (gc) and esophageal cancer (ec) share risk factors, and the incidence trends reflect differences in etiology according to their subtypes. we aimed to describe the incidence trends of gc (by topography) and ec (by histological type) in northern portugal for 1994-2009 and to estimate the incidence for 2015. we further analyzed exposure to the main risk factors for these cancers in the region over the last decades. | 2017 | 27647232 |
| the appropriate use of proton pump inhibitors (ppis): need for a reappraisal. | the advent of powerful acid-suppressive drugs, such as proton pump inhibitors (ppis), has revolutionized the management of acid-related diseases and has minimized the role of surgery. the major and universally recognized indications for their use are represented by treatment of gastro-esophageal reflux disease, eradication of helicobacter pylori infection in combination with antibiotics, therapy of h. pylori-negative peptic ulcers, healing and prophylaxis of non-steroidal anti-inflammatory drug- ... | 2017 | 27784575 |
| icos(+) foxp3(+) tils in gastric cancer are prognostic markers and effector regulatory t cells associated with helicobacter pylori. | regulatory t cells (tregs) have an immunosuppressive role in the tumor microenvironment. since effector tregs (etregs), which have highly suppressive functions, are located in a subpopulation of foxp3(+) cd4(+) tregs, the tcr-inducible costimulatory receptor (icos) was applied as a marker of etregs that infiltrated gastric cancer tissue and the induction pathway of icos(+) foxp3(+) cells was analyzed by flow cytometry and immunohistochemistry. in tumor-infiltrating lymphocytes (tils), icos(+) fo ... | 2017 | 27756099 |
| helicobacter pylori-negative gastric cancer: advanced-stage undifferentiated adenocarcinoma located in the pyloric gland area. | the incidence of helicobacter pylori-negative gastric cancer (hpngc) is extremely low. a 78-year old female without h. pylori infection was diagnosed with type 4 advanced-stage gastric prepylorus cancer. distal gastrectomy was performed as for hpngc (ct3n0m0). histological findings of the resected specimen showed poorly differentiated adenocarcinoma and signet ring cell carcinoma, which were located in the pyloric gland area, diffusely invaded beyond the serosa without lymph node metastasis (pt4 ... | 2017 | 27783218 |
| population attributable burden of helicobacter pylori-related gastric cancer, coronary heart disease, and ischemic stroke in china. | helicobacter pylori, a risk factor of cancer and chronic diseases, remains highly prevalent in china. this review aims to systematically evaluate the h. pylori-attributable burden for gastric cancer (gc), coronary heart disease (chd), and ischemic stroke (is) in the chinese population. helicobacter pylori prevalence was updated by pooling the results reported in studies across china. the population attributable fraction (paf) was calculated based on the h. pylori prevalence 10 years ago and rela ... | 2017 | 27771779 |
| clinicopathological characteristics of invasive gastric helicobacter pylori. | helicobacter pylori organisms have been observed deep within the stomach mucosa with an "intracellular" appearance, although the clinicopathological characteristics of such cases remain poorly understood. we analyzed 18 cases of deep mucosal h pylori and associated clinical (sex, age, history of h pylori infection, or proton pump inhibitor [ppi] use, medications, smoking, alcohol use, comorbidities, treatment response) and pathological (presence of lymphoid aggregates, intestinal metaplasia, ppi ... | 2017 | 27771376 |
| secretomic analysis of host-pathogen interactions reveals that elongation factor-tu is a potential adherence factor of helicobacter pylori during pathogenesis. | the secreted proteins of bacteria are usually accompanied by virulence factors, which can cause inflammation and damage host cells. identifying the secretomes arising from the interactions of bacteria and host cells could therefore increase understanding of the mechanisms during initial pathogenesis. the present study used a host-pathogen coculture system of helicobacter pylori and monocytes (thp-1 cells) to investigate the secreted proteins associated with initial h. pylori pathogenesis. the se ... | 2017 | 27764940 |
| fucosyltransferase-4 and oligosaccharide lewis y antigen as potentially correlative biomarkers of helicobacter pylori caga associated gastric cancer. | h. pylori cytotoxin associated antigen a (caga) plays a significant role in the progression of gastric cancer but their effect on fucosylation to develop gastric cancer is unknown. fucosyltransferase iv (fut4) is the key enzyme for synthesis of lewisy (ley) carried by glycoproteins and glycolipids on the cell membrane. herein, we compare the expression of caga, p-egfr, fut4 and ley in gastritis (n = 128, 176), gastric ulcer (n = 174, 213), and gastric cancer (n = 323, 261) tissue and serum sampl ... | 2017 | 27757838 |
| changing epidemiology of helicobacter pylori in japan. | helicobacter pylori (h. pylori) is known as the most important cause of gastric cancer. the prevalence of h. pylori infection varies widely by geographic area, age, and socioeconomic status. in japan, h. pylori infection has been highly correlated with the incidence rate of gastric cancer, and a reduction in h. pylori infection is therefore crucial for decreasing the incidence of gastric cancer, especially at the population level. infection occurs during childhood, commonly before 5 years of age ... | 2017 | 27757699 |
| inefficacy of triple therapy and comparison of two different bismuth-containing quadruple regimens as a firstline treatment option for helicobacter pylori. | increasing resistance of helicobacter pylori to antimicrobials necessitated the development of new regimens and the modification of existing regimens. the present study aimed to compare the efficacy of two bismuth-containing quadruple regimens-one including clarithromycin (c) instead of metronidazole (m) and triple therapy. | 2017 | 27748322 |
| natural (18)o and (13)c-urea in gastric juice: a new route for non-invasive detection of ulcers. | the (13)c-urea breath test ((13)c-ubt), developed a few decades ago, is widely used as a non-invasive diagnostic method to detect only the presence of the gastric pathogen helicobacter pylori infection; however, the actual disease state, i.e. whether the person harbouring h. pylori has peptic ulcer disease (pud) or non-ulcerous dyspepsia (nud), is still poorly understood. nevertheless, the present (13)c-ubt has numerous limitations, drawbacks and pitfalls owing to the ingestion of (13)c-labelled ... | 2017 | 27747374 |
| evaluation of the potential inhibitory activity of a combination of l. acidophilus, l. rhamnosus and l. sporogenes on helicobacter pylori: a randomized double-blind placebo-controlled clinical trial. | to investigate whether three strains of probiotics, l. acidophilus, l. rhamnosus, and l. sporogenes, had signifificant inhibitive effects on helicobacter pylori (h. pylori). | 2017 | 27761791 |
| assessment of antibacterial effect of garlic in patients infected with helicobacter pylori using urease breath test. | helicobacter pylori (h. pylori) is the most common pathogenic bacteria in the stomach. the aim of the current study was to explore the effect of oral garlic administration on bacterial urease activity inside the stomach and its contribution to the treatment of h. pylori infection. | 2017 | 27761418 |
| prevalence of helicobacter pylori ten years ago compared to the current prevalence in patients undergoing upper endoscopy. | helicobacter pylori has been extensively studied since 1982 it is estimated that 50% of the world population is affected. the literature lacks studies that show the change of its prevalence in the same population over time. | 2017 | 27759776 |
| relationship between the presence of helicobacter pylori with inflammatory endoscopic changes in gastroduodenal mucosa. | the influence of helicobacter pylori (hp) in inflammatory disorders of the digestive mucosa has been the subject of several studies since socioeconomic, personal and environmental factors were implicated in the bacteria transmission. | 2017 | 27759774 |
| relationship between esophagitis grades and helicobacter pylori. | the helicobacter pylori infection (hp) is related to the development of gastric lesions and lymphoma; however, it is not known if there is a relation with gastroesophageal reflux disease and reflux esophagitis. | 2017 | 27759772 |
| helicobacter pylori colonization and pregnancies complicated by preeclampsia, spontaneous prematurity, and small for gestational age birth. | preeclampsia (pe), small for gestational age (sga), and spontaneous preterm birth (ptb) each may be complications of impaired placental function in pregnancy. although their exact pathogenesis is still unknown, certain infectious agents seem to play a role. helicobacter pylori (h. pylori) colonization has been associated with increased risk for pe. our aim was to assess the association between h. pylori colonization and pe, sga, and ptb. | 2017 | 27786400 |
| helicobacter pylori infection and its related factors in junior high school students in nagano prefecture, japan. | there have been few reports on helicobacter pylori (h. pylori) infection in asymptomatic japanese children and adolescents. we hypothesized that the prevalence of h. pylori infection is very low among japanese children and that clinical variables such as serum pepsinogen and iron levels are associated with h. pylori infection. | 2017 | 27785853 |
| mechanisms for the induction of gastric cancer by helicobacter pylori infection: aberrant dna methylation pathway. | multiple pathogenic mechanisms by which helicobacter pylori infection induces gastric cancer have been established in the last two decades. in particular, aberrant dna methylation is induced in multiple driver genes, which inactivates them. methylation profiles in gastric cancer are associated with specific subtypes, such as microsatellite instability. recent comprehensive and integrated analyses showed that many cancer-related pathways are more frequently altered by aberrant dna methylation tha ... | 2017 | 27718135 |
| is the immunocromatographic fecal antigen test effective for primary diagnosis of helicobacter pylori infection in dyspeptic patients? | the diagnosis of h. pylori infection can be performed by non-invasive and invasive methods.the identification through a fecal antigen test is a non-invasive, simple, and relatively inexpensive test. | 2017 | 27706450 |
| drug resistance in helicobacter pylori. | helicobacter pylori has a worldwide distribution and is associated with the pathogenesis of various diseases of the digestive system. treatment to eradicate this microorganism involves the use of a combination of antimicrobials, such as amoxicillin, metronidazole, clarithromycin, and levofloxacin, combined with proton pump inhibitors. although the current therapy is effective, a high rate of treatment failure has been observed, mainly because of the acquisition of point mutations, one of the maj ... | 2017 | 27706449 |
| drug resistance in helicobacter pylori. | 2017 | 27706448 | |
| increased plasmacytic differentiation in gastric mucosa-associated lymphoid tissue lymphomas: helicobacter pylori eradication response and igg4+ plasma cell association. | gastric mucosa-associated lymphoid tissue (malt) lymphoma is a rare extranodal marginal zone b-cell lymphoma that is often associated with plasmacytic differentiation. however, the clinicopathological characteristics of gastric malt lymphoma with increased plasmacytic differentiation have not yet been studied. to assess the clinicopathological implications of gastric malt lymphoma with increased plasmacytic differentiation, 36 cases with increased plasmacytic differentiation and a control group ... | 2017 | 27697589 |
| is gastroscopy for fecal immunochemical test positive patients worthwhile? | the use of fecal immunochemical test (fit) in the screening for colorectal cancer is long established. however, more than 50 % of patients with positive fits have a negative colonoscopy. the role of a subsequent oesophago-gastro-duodenoscopy (ogd) is debatable. the aim of this study is to evaluate the yield of ogd in patients with positive fits. | 2017 | 27695973 |
| prevalence of helicobacter pylori infection in newly arrived refugees attending the migrant health service, south australia. | to determine the prevalence of helicobacter pylori infection in the refugee population attending the migrant health service, south australia, identify demographic factors associated with infection and compare prevalence of infection in refugees with that of the nonrefugee population in australia. | 2017 | 27717096 |
| use of random and site-directed mutagenesis to probe protein structure-function relationships: applied techniques in the study of helicobacter pylori. | mutagenesis is a valuable tool to examine the structure-function relationships of bacterial proteins. as such, a wide variety of mutagenesis techniques and strategies have been developed. this chapter details a selection of random mutagenesis methods and site-directed mutagenesis procedures that can be applied to an array of bacterial species. additionally, the direct application of the techniques to study the helicobacter pylori ferric uptake regulator (fur) protein is described. the varied app ... | 2017 | 27709595 |
| transient receptor potential vanilloid 4 (trpv4) silencing in helicobacter pylori-infected human gastric epithelium. | helicobacter pylori (hp) infection induces methylation silencing of specific genes in gastric epithelium. various stimuli activate the nonselective cation channel trpv4, which is expressed in gastric epithelium where it detects mechanical stimuli and promotes atp release. as cpg islands in trpv4 are methylated in hp-infected gastric epithelium, we evaluated hp infection-dependent changes in trpv4 expression in gastric epithelium. | 2017 | 27687509 |
| gastric and jejunal histopathological changes in patients undergoing bariatric surgery. | morbid obesity is a multifactorial disease that increasingly is being treated by surgery. | 2017 | 27683773 |
| inflammatory disorders associated with helicobacter pylori in the roux-en-y bypass gastric pouch. | the prevalence of helicobacter pylori in obese candidates for bariatric surgery and its role in the emergence of inflammatory lesions after surgery has not been well established. | 2017 | 27683772 |
| prevalence of helicobacter pylori from the oral cavity of mexican asymptomatic children under 5 years of age through pcr. | h. pylori infection is acquired early in life, but symptoms occur mainly in adults. the mode of transmission remains unclear, but several studies have demonstrated that the microorganism may be transmitted orally. h. pylori has been detected in the oral cavity of children, and some authors have studied infection prevalence due to the importance of the bacteria in gastric and extragastric pathology. in méxico, little is known about h. pylori prevalence in the oral cavity of asymptomatic children, ... | 2017 | 27665274 |
| clinical comparative study of the effects of helicobacter pylori colonization on oral health in children. | to isolate helicobacter pylori (hp) from the dental plaque of a selected group of children and to compare the oral and salivary findings of patients with those of a healthy control group. | 2017 | 27648050 |
| an enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and its potential anticancer application. | enzymatic glycosylation of sterols/steroids with glycosyltransferase hp0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated mcf-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities. | 2017 | 27647631 |
| similar efficacy of proton-pump inhibitors vs h2-receptor antagonists in reducing risk of upper gastrointestinal bleeding or ulcers in high-risk users of low-dose aspirin. | it is not clear whether h2-receptor antagonists (h2ras) reduce the risk of gastrointestinal (gi) bleeding in aspirin users at high risk. we performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (ppi) vs a h2ra antagonist in preventing recurrent upper gi bleeding and ulcers in high-risk aspirin users. | 2017 | 27641510 |
| assessment of sequential and standard triple therapy in treatment of helicobacter pylori infection in children dependent on bacteria sensitivity to antibiotics. | in the last decade a 10-day schema of sequential therapy of helicobacter pylori infection based on proton pomp inhibitor (ppi), amoxicillin (amo), clarithromycin (cla) and metronidazole (met) has been introduced. many studies have emphasized greater efficacy of this therapy in comparison to the efficacy of the standard 7-day triple therapy (ppi + amo + cla or met). | 2017 | 27629844 |
| efficacy of levofloxacin-based third-line therapy for the eradication of helicobacter pylori in peptic ulcer disease. | the resistance rate of helicobacter pylori is gradually increasing. we aimed to evaluate the efficacy of levofloxacin-based third-line h. pylori eradication in peptic ulcer disease. | 2017 | 27609487 |
| helicobacter pylori and preeclampsia. | 2017 | 27600628 | |
| 18f-fdg pet/ct in gastric malt lymphoma: a bicentric experience. | the role of 18f-fdg-pet/ct in evaluating gastric malt lymphoma is still controversial. in the literature the detection rate of 18f-fdg-pet/ct in patients with gastric malt lymphoma is variable, and the reason for this heterogeneity is not still clear. our aim was to investigate the particular metabolic behavior of these lymphoma. | 2017 | 27619357 |
| non-invasive detection and successful treatment of a helicobacter pylori infection in a captive rhesus macaque. | gastritis is a commonly diagnosed condition in non-human primates used in biomedical research. as in humans, helicobacter pylori infection may cause gastritis. the following report presents a method of non-invasive detection and a successful treatment protocol for this common pathogen. | 2017 | 27609810 |
| in vitro culture and phenotypic and molecular characterization of gastric stem cells from human stomach. | human gastric mucosa shows continuous self-renewal via differentiation from stem cells that remain poorly characterized. | 2017 | 27592706 |
| helicobacter pylori-induced cell death is counteracted by nf-κb-mediated transcription of darpp-32. | darpp-32 is a frequently amplified and overexpressed gene that promotes several oncogenic functions in gastric cancer. herein, we investigated the relationship between helicobacter pylori infection, proinflammatory nf-κb activation and regulation of darpp-32. | 2017 | 27590997 |
| functional (13)c-urea and glucose hydrogen/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active helicobacter pylori infection. | helicobacter pylori infection is considered to alter the bacterial flora in the upper gastrointestinal tract. this study aimed at investigating the presence of small intestinal bacterial overgrowth (sibo) in patients with active h. pylori infection assessed by functional breath testing. | 2017 | 27586816 |
| binary mixture of satureja hortensis and origanum vulgare subsp. hirtum essential oils: in vivo therapeutic efficiency against helicobacter pylori infection. | helicobacter pylori can cause many gastrointestinal and also extra-gastrointestinal disorders and is a major risk factor for gastric carcinoma and malt lymphoma. currently, numerous antibiotic-based therapies are available; however, these therapies have numerous drawbacks, mainly due to increasing prevalence of antibiotic resistant strains. thus, there is an urgent need to develop novel therapeutic agents against h. pylori infections. | 2017 | 27578489 |
| helicobacter pylori and gastric cancer: timing and impact of preventive measures. | helicobacter pylori (h. pylori) is a gram negative spiraliform bacterium that is commonly found in the stomach. h. pylori infection is still one of the world's most frequent infections, present in the stomachs of approximately one-half of the world's people. h. pylori infection is etiologically linked to histologic chronic active gastritis, peptic ulcer disease, and primary b-cell gastric lymphoma (gastric malt lymphoma) and represents the major risk factor for the development of sporadic non-ca ... | 2017 | 27573783 |
| helicobacter pylori, cancer, and the gastric microbiota. | gastric adenocarcinoma is one of the leading causes of cancer-related death worldwide and helicobacter pylori infection is the strongest known risk factor for this disease. although the stomach was once thought to be a sterile environment, it is now known to house many bacterial species leading to a complex interplay between h. pylori and other residents of the gastric microbiota. in addition to the role of h. pylori virulence factors, host genetic polymorphisms, and diet, it is now becoming cle ... | 2017 | 27573782 |
| syndromic gastric polyps: at the crossroads of genetic and environmental cancer predisposition. | gastric polyps occur in 1-4 % of patients undergoing gastroscopy. although most are sporadic, some gastric polyps are part of an underlying hereditary syndrome. gastric polyps can be seen in each of the well-known gastrointestinal polyposis syndromes, but also in lynch syndrome and in several rare not primarily gastrointestinal syndromes. in addition, gastric adenocarcinoma and proximal polyposis of the stomach (gapps) is a recently described heritable syndrome characterized by isolated gastric ... | 2017 | 27573780 |
| the japanese viewpoint on the histopathology of early gastric cancer. | japanese histopathologists have traditionally had greater opportunity to study the histology and clinical course of early gastric cancer because of technological developments including double contrast radiography and endoscopy systems, combined with the higher incidence of gastric cancer in the general population in japan. endoscopic resection is now considered best practice for treatment of early gastric cancers with a negligible risk of lymph node metastasis. histopathologic evaluation plays a ... | 2017 | 27573779 |
| endoluminal diagnosis of early gastric cancer and its precursors: bridging the gap between endoscopy and pathology. | although dye-based and image-enhanced endoscopic techniques have revolutionized endoscopic diagnosis, conventional white light endoscopy still plays an important role in the diagnosis of early gastric cancer (egc) during routine endoscopy. chromoendoscopy reveals morphological characteristics of the mucosal lesions by enhancing mucosal contrast, while narrow-band imaging (nbi) facilitates detailed evaluation of the vascular architecture and surface features. positive diagnostic findings of egc o ... | 2017 | 27573777 |
| russell body inflammatory polyp. | russell body gastroenteritis has been reported as a reactive inflammatory process in most cases and many of the reports were from the upper gastrointestinal tract, especially the stomach, which may be associated with helicobacter pylori infection and rarely associated with gastric carcinoma. russell body containing mott cells have been rarely seen in barrett's esophagus and duodenum, and only 2 cases have been reported in colon, including a transplant patient with diarrhea and a rectal tubulovil ... | 2017 | 27571792 |
| call for global vaccine instead of helicobacter pylori blind antibiotic therapy. | 2017 | 27549421 |