Publications

early inflammatory and metabolic changes in association with agtr1 polymorphisms in prehypertensive subjects.	the seventh joint national committee on prevention, detection, evaluation, and treatment of high blood pressure in 2003 created a prehypertension category for persons with blood pressures ranging from systolic blood pressure (sbp) of 120-139 mm hg or diastolic blood pressure (dbp) from 80 to 89 mm hg, due to increased risk of cardiovascular disease.	2010	20864943
clinical efficacy of raltegravir against b and non-b subtype hiv-1 in the startmrk and benchmrk studies.	objective: we evaluated the long-term efficacy of raltegravir according to hiv-1 subtype (b and non-b) using data from 3 phase iii studies in treatment-experienced (benchmrk) and treatment-naïve (startmrk) hiv-infected patients. methods: hiv-1 subtypes were identified from baseline plasma specimens using genotypic data of the phenosense gt test (monogram biosciences). non-b subtypes were combined for the current analyses due to small numbers of each specific subtype. an observed failure (of) app ...	2010	21522004
image cytometric validation of breast carcinoma markers (er, her2 and mib-1) using tissue microarrays: rabbit monoclonal vs. fda-approved antibodies.	to use the acis iii (dako, carpinteria, california, u.s.a.) with tissue microarrays (tmas) to compare rabbit monoclonal antibodies (rmab) for er, her2, and mib-1 with fda-approved monoclonal (fmab) and polyclonal (fpab) antibodies.	2010	21434519
governor pio pico, the monster of california...no more: lessons in neuroendocrinology.	we hypothesize that pio pico, the last mexican governor of california, had acromegaly between at least ages 43 to 57, from 1844 to 1858, before pierre marie published the clinical description of acromegaly in 1886. pico's probable growth hormone-secreting pituitary tumor likely infarcted spontaneously after 1858. the tumor infarction resulted in burnt-out acromegaly and probably restored normal pituitary function. pearce bailey published the first account of pituitary tumor infarction only in 18 ...	2010	18597174
trophy-taking and dismemberment as warfare strategies in prehistoric central california.	we document evidence for trophy-taking and dismemberment with a new bioarchaeological database featuring 13,453 individuals from prehistoric central california sites. our study reveals 76 individuals with perimortem removal of body parts consistent with trophy-taking or dismemberment; nine of these individuals display multiple types of trophy-taking and dismemberment for a total of 87 cases. cases span almost 5,000 years, from the early period (3000-500 bc) to the late period (ad 900-1700). coll ...	2010	19544576
human physique and sexual attractiveness in men and women: a new zealand-u.s. comparative study.	men and women living in new zealand and california completed five studies regarding human physique and sexual attractiveness. in studies 1-3, women rated images of male stimuli and, in studies 4-5, men rated female stimuli. in study 1, women in both countries rated mesomorphic (muscular) and average male somatotypes as most attractive, followed by ectomorphic (slim) and endomorphic (heavily built) figures. in study 2, amount and distribution of masculine trunk hair (chest and abdominal) was alte ...	2010	19139985
genetic variation in cyp17a1 and pancreatic cancer in a population-based case-control study in the san francisco bay area, california.	pancreatic cancer is the fourth leading cause of cancer-related death in men and women in the united states. reproductive factors and steroid hormones have been suspected risk factors for many years, but the results from epidemiologic studies to date have been inconclusive. cyp17a1 encodes cytochrome p450c17alpha, an enzyme with 17alpha-hydroxylase and 17,20-lyase activities in estradiol biosynthesis. a polymorphism in the 5'utr promoter region of cyp17a1-34t/c(a1/a2) has been associated with ci ...	2010	19642097
sporotrichosis: a retrospective evaluation of 23 cases seen in northern california (1987-2007).	sporotrichosis is an uncommon to rare cutaneous and subcutaneous mycosis of animals and humans caused by the dimorphic fungus sporothrix schenckii. twenty-three mammalian cases of sporotrichosis examined between 1987 and 2007 at the university of california, davis - veterinary medical teaching hospital, were retrospectively evaluated with regard to the historical, clinical, diagnostic and treatment findings. cats were the most common species affected (n = 14). in addition, sporotrichosis was dia ...	2009	19659536
strategies for pandemic and seasonal influenza vaccination of schoolchildren in the united states.	vaccinating school-aged children against influenza can reduce age-specific and population-level illness attack rates. using a stochastic simulation model of influenza transmission, the authors assessed strategies for vaccinating children in the united states, varying the vaccine type, coverage level, and reproductive number r (average number of secondary cases produced by a typical primary case). results indicated that vaccinating children can substantially reduce population-level illness attack ...	2009	19679750
illnesses associated with chloropicrin use in california agriculture, 1992-2003.	with limitations imposed on the use of methyl bromide by international treaty, use of metam-sodium, chloropicrin, and other fumigants have increased; this increase has been accompanied by multiple community illness episodes. in this review we address the california experience of direct or indirect exposures to chloropicrin, after use of this fumigant as an active ingredient in agricultural pest control, from the years 1992-2003. the best available toxicology data demonstrate that, for brief expo ...	2009	19680609
a randomized controlled trial evaluating an alternative mouse or forearm support on change in median and ulnar nerve motor latency at the wrist.	the purpose of this study was to determine the effects of an alternative mouse and/or a forearm support board on nerve function at the wrist among engineers.	2009	19142961
polychlorinated biphenyls (pcbs) and their hydroxylated metabolites (oh-pcbs) in livers of harbor seals (phoca vitulina) from san francisco bay, california and gulf of maine.	bioaccumulation of endocrine disruptors in marine mammals positioned at the top of the food chain is of toxicological concern. livers from four pups and ten adult harbor seals (phoca vitulina) stranded in san francisco bay (sfb) and the gulf of maine (gom) were analyzed for polychlorinated biphenyls (pcbs) and their hydroxylated metabolites (oh-pcbs). we used gc-ecd and gc-nci/ms to investigate the presence of 28 pcbs and 8 oh-pcb metabolites, respectively. sigma(28)pcb concentrations (di- to oc ...	2009	19150735
genetic polymorphisms in the thioredoxin 2 (txn2) gene and risk for spina bifida.	txn2 encodes human thioredoxin 2, a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. txn2 knockout mice fail to complete neural tube closure by e10.5 and die in utero. we hypothesized that genetic variation in human txn2 gene may alter the function of the encoded protein in a manner associated with an increased risk for neural tube defects (ntds). a dna re-sequencing effort of the human txn2 gene was taken. after a variation in the promot ...	2009	19165900
fishing from past to present: continuity and resilience of red abalone fisheries on the channel islands, california.	archaeological data from coastal shell middens provide a window into the structure of ancient marine ecosystems and the nature of human impacts on fisheries that often span millennia. for decades channel island archaeologists have studied middle holocene shell middens visually dominated by large and often whole shells of the red abalone (haliotis rufescens). here we use modern ecological data, historical accounts, commercial red abalone catch records, and zooarchaeological data to examine long-t ...	2009	19544733
role of metabolic syndrome components in human immunodeficiency virus-associated stroke.	metabolic syndrome (mets) is a cluster of risk factors, including elevated mean arterial pressure (map), atherogenic dyslipidemia (elevated triglycerides [trg]), abdominal obesity (increased body mass index [bmi]), glucose intolerance (elevated glucose [glu]), and prothrombotic/inflammatory state (increases in uric acid [ua]), that are associated with increased risk of cerebrovascular disease. we studied if an association existed between mets components and human immunodeficiency virus (hiv)-ass ...	2009	19562611
a multimodal aging and dying course for first-year medical students improves knowledge and attitudes.	when medical schools change their curricula, this opens up opportunities for the development of new material and often eliminates previously designed courses. emory university's school of medicine revised its curriculum in 2007, combining clinical medicine and basic sciences in the first 18 months. as part of its first section on "the healthy human," it included a weeklong module on aging. the main objective of this study was to evaluate attitudes and knowledge about aging issues before and afte ...	2009	19563520
rapid-test sensitivity for novel swine-origin influenza a (h1n1) virus in humans.		2009	19564634
percutaneous suture edge-to-edge repair of the mitral valve.	to describe a new approach to percutaneous mitral valve repair and an illustrative first-in-man experience, we introduce a suture mediated "double orifice", "edge-to-edge" procedure which can be an effective surgical therapy for mitral regurgitation (mr) in selected patient.	2009	19577987
influenza vaccination among adults with asthma findings from the 2007 brfss survey.	asthma prevalence among u.s. adults is estimated to be 6.7%. people with asthma are at increased risk of complications from influenza. influenza vaccination of adults and children with asthma is recommended by the advisory committee on immunization practices. the healthy people 2010 objectives call for annual influenza vaccination of at least 60% of adults aged 18-64 years with asthma and other conditions associated with an increased risk of complications from influenza.	2009	19589448
evaluation of four cell lines for assay of infectious adenoviruses in water samples.	human viral contamination in drinking and recreational waters poses health risks. the application of pcr-based molecular technology has advanced our knowledge of the occurrence and prevalence of human viruses in water; however, it has provided no information on viral viability and infectivity. four human cell lines were compared for their sensitivity to different serotypes of human adenoviruses using the tcid50 test. the sensitivity of each cell line varied with different serotypes of adenovirus ...	2009	19590132
imported human rabies--california, 2008.	compared with rabies in developing countries, human rabies is rare in the united states, but animal rabies is common. in the united states, most human rabies cases are associated with rabid bats, whereas in developing countries, dogs are the most common reservoir and vector species. in march 2008, a case of imported human rabies in a recently arrived, undocumented mexican immigrant was laboratory confirmed by public health officials in california. the rabies virus isolated from the patient was a ...	2009	19590490
increased hemoglobin associated with vegf inhibitors in advanced renal cell carcinoma.	we retrospectively analyzed whether increased hemoglobin is a surrogate biomarker of efficacy for vascular endothelial growth factor (vegf) inhibitors in advanced renal cell carcinoma (rcc) patients. twelve patients were identified who had received bevacizumab alone or as combination therapy. eleven patients experienced a rise in hemoglobin. median change was 1.6 g/dl (0-4.0). degree of peak increase correlated with longer progression-free survival (pfs) in metastatic patients: increase of < 15% ...	2009	19603304
influenza vaccination and mortality: differentiating vaccine effects from bias.	it is widely believed that influenza (flu) vaccination of the elderly reduces all-cause mortality, yet randomized trials for assessing vaccine effectiveness are not feasible and the observational research has been controversial. efforts to differentiate vaccine effectiveness from selection bias have been problematic. the authors examined mortality before, during, and after 9 flu seasons in relation to time-varying vaccination status in an elderly california population in which 115,823 deaths occ ...	2009	19625341
low stage follicular lymphoma: biologic and clinical characterization according to nodal or extranodal primary origin.	studies suggest that primary extranodal follicular lymphoma (fl) is not infrequent but it remains poorly characterized with variable histologic, molecular, and clinical outcome findings. we compared 27 extranodal fl to 44 nodal fl using morphologic, immunohistochemical, and molecular genetic techniques and evaluated the clinical outcome of these 2 similarly staged groups. eight cases of primary cutaneous follicle center lymphoma were also studied. in comparison to nodal fl, a greater number of e ...	2009	19065102
chromosomal abnormalities among children born with conotruncal cardiac defects.	conotruncal heart defects compose 25% to 30% of nonsyndromic congenital heart defects. this study describes the frequency of chromosome abnormalities and microdeletion of 22q11 associated among infants and fetuses delivered with conotruncal heart malformations.	2009	19067405
a public health model for the molecular surveillance of hiv transmission in san diego, california.	current public health efforts often use molecular technologies to identify and contain communicable disease networks, but not for hiv. here, we investigate how molecular epidemiology can be used to identify highly related hiv networks within a population and how voluntary contact tracing of sexual partners can be used to selectively target these networks.	2009	19098493
polybrominated diphenyl ether flame retardants in the u.s. marine environment: a review.	polybrominated diphenyl ethers (pbdes) are used as flame retardants in polymeric materials such as furnishing foam, rigid plastics and textiles. the u.s. has historically led the world production of these man-made chemicals and was responsible for about 50% of the total global demand in 2001. paradoxically, scientific studies addressing sources, behavior and fate of pbdes in the u.s. environment are limited when compared to those in europe. this paper reviews the distribution of pbdes in marine ...	2009	19100622
an area-level model of vehicle-pedestrian injury collisions with implications for land use and transportation planning.	there is growing awareness among urban planning, public health, and transportation professionals that design decisions and investments that promote walking can be beneficial for human and ecological health. planners need practical tools to consider the impact of development on pedestrian safety, a key requirement for the promotion of walking. simple bivariate models have been used to predict changes in vehicle-pedestrian injury collisions based on changes in traffic volume. we describe the devel ...	2009	19114148
evaluation of the first year of a pilot program in community pharmacy: hiv/aids medication therapy management for medi-cal beneficiaries.	the advent of combined antiretroviral therapy (art) has increased treatment effectiveness but created new challenges for patients infected with human immunodeficiency virus (hiv) and for community pharmacists managing patients' drug therapy. the ability of pharmacist-provided medication therapy management (mtm) services to increase medication adherence, improve health outcomes, and reduce overall medical costs has been demonstrated in community pharmacies for chronic diseases such as diabetes an ...	2009	19125548
zoonotic bartonella species in fleas collected on gray foxes (urocyon cinereoargenteus).	bartonella spp. are fastidious, gram-negative, rod-shaped bacteria and are usually vector-borne. however, the vector has not been definitively identified for many recently described species. in northern california, gray foxes (urocyon cinereoargenteus) are infected with two zoonotic bartonella species, b. rochalimae and b. vinsonii subsp. berkhoffii. fleas (range 1-8 fleas per fox) were collected from 22 (41.5%) of 54 gray foxes from urban and backcountry zones near hoopa, california. the flea s ...	2009	19125660
frequency and etiology of solitary hot spots in the pelvis at whole-body positron emission tomography/computed tomography imaging.	to determine the frequency and etiology of a single hypermetabolic focus within the pelvis with no other areas of increased 18-fluorodeoxyglucose (fdg) uptake in the reminder of the whole body in an oncological population.	2009	19135929
biogeographic patterns in genomic diversity among a large collection of vibrio cholerae isolates.	vibrio cholerae strains are capable of inhabiting multiple niches in the aquatic environment and in some cases cause disease in humans. however, the ecology and biodiversity of these bacteria in environmental settings remains poorly understood. we used the genomic fingerprinting technique enterobacterial repetitive intergenic consensus sequence pcr (eric-pcr) to profile 835 environmental isolates from waters and sediments obtained at nine sites along the central california coast. we identified 1 ...	2009	19139224
hospitalized patients with novel influenza a (h1n1) virus infection - california, april-may, 2009.	since april 15 and 17, 2009, when the first two cases of novel influenza a (h1n1) infection were identified from two southern california counties, novel influenza a (h1n1) cases have been documented throughout the world, with most cases occurring in the united states and mexico. in the united states, early reports of illnesses associated with novel influenza a (h1n1) infection indicated the disease might be similar in severity to seasonal influenza, with the majority of patients not requiring ho ...	2009	19478723
atmospheric chemistry: the man who smells forests.		2009	19478760
what's needed next: a culture of candor.	if there's one thing that the past decade's business disasters should teach us, it's that we need to stop evaluating corporate leaders simply on the basis of how much wealth they create for investors. a healthier yardstick would be this: the extent to which leaders create firms that are economically, ethically, and socially sustainable. the first step toward accomplishing that task is to create a culture of candor. companies can't innovate, respond to stakeholder needs, or run efficiently unless ...	2009	19496471
new perspectives in human stem cell therapeutic research.	human stem cells are in evaluation in clinical stem cell trials, primarily as autologous bone marrow studies, autologous and allogenic mesenchymal stem cell trials, and some allogenic neural stem cell transplantation projects. safety and efficacy are being addressed for a number of disease state applications. there is considerable data supporting safety of bone marrow and mesenchymal stem cell transplants but the efficacy data are variable and of mixed benefit. mechanisms of action of many of th ...	2009	19519878
bartonella quintana in body lice and head lice from homeless persons, san francisco, california, usa.	bartonella quintana is a bacterium that causes trench fever in humans. past reports have shown bartonella spp. infections in homeless populations in san francisco, california, usa. the california department of public health in collaboration with san francisco project homeless connect initiated a program in 2007 to collect lice from the homeless to test for b. quintana and to educate the homeless and their caregivers on prevention and control of louse-borne disease. during 2007-2008, 33.3% of bod ...	2009	19523290
the incidence and clinical characteristics of herpes zoster among children and adolescents after implementation of varicella vaccination.	the varicella-zoster virus (vzv) vaccine strain may reactivate to cause herpes zoster. limited data suggest that the risk of herpes zoster in vaccinated children could be lower than in children with naturally acquired varicella. we examine incidence trends, risk and epidemiologic and clinical features of herpes zoster disease among children and adolescents by vaccination status.	2009	19536039
the complete genome of klassevirus - a novel picornavirus in pediatric stool.	diarrhea kills 2 million children worldwide each year, yet an etiological agent is not found in approximately 30-50% of cases. picornaviral genera such as enterovirus, kobuvirus, cosavirus, parechovirus, hepatovirus, teschovirus, and cardiovirus have all been found in human and animal diarrhea. modern technologies, especially deep sequencing, allow rapid, high-throughput screening of clinical samples such as stool for new infectious agents associated with human disease.	2009	19538752
a prospective, multicenter, randomized trial to assess efficacy of pioglitazone on in-stent neointimal suppression in type 2 diabetes: popps (prevention of in-stent neointimal proliferation by pioglitazone study).	the aim of this study was to clarify whether pioglitazone suppresses in-stent neointimal proliferation and reduces restenosis and target lesion revascularization (tlr) after percutaneous coronary intervention (pci).	2009	19539256
spatial spreading of west nile virus described by traveling waves.	in this work, we propose a spatial model to analyze the west nile virus propagation across the usa, from east to west. west nile virus is an arthropod-borne flavivirus that appeared for the first time in new york city in the summer of 1999 and then spread prolifically among birds. mammals, such as humans and horses, do not develop sufficiently high bloodstream titers to play a significant role in the transmission, which is the reason to consider the mosquito-bird cycle. the model aims to study t ...	2009	19167405
local veterinary diagnostic laboratory, a model for the one health initiative.	the san diego county animal disease diagnostic laboratory (addl) is unique in its emphasis on protecting both human and animal health in san diego county, and its use of interagency and community collaboration to create strong, effective public health programs. this article describes the addl core programs of avian and vector-borne disease surveillance, rabies testing, and animal abuse investigations and uses selected case studies to illustrate the need for a local veterinary diagnostic laborato ...	2009	19185199
distribution and diversity of the enterococcal surface protein (esp) gene in animal hosts and the pacific coast environment.	this study sought to evaluate the distribution of the enterococcal surface protein (esp) gene in enterococcus faecium in the pacific coast environment as well as the distribution and diversity of the gene in northern california animal hosts.	2009	19187132
repeated west nile virus epidemic transmission in kern county, california, 2004-2007.	west nile virus (wnv) has remained epidemic in kern county, ca, since its introduction in 2004 through 2007 when the human case annual incidence increased from 6-8 to 17 per 100,000, respectively. the 2007 increase in human infection was associated with contradicting surveillance indicators, including severe drought, warm spring but cool summer temperature anomalies, decreased rural and urban mosquito abundance but increased early season infection in urban culex quinquefasciatus say, moderate av ...	2009	19198528
multimedia transport and risk assessment of organophosphate pesticides and a case study in the northern san joaquin valley of california.	this paper presents a framework for cumulative risk characterization of human exposure to pesticides through multiple exposure pathways. this framework is illustrated through a case study of selected organophosphate (op) pesticides in the northern san joaquin valley of california. chemical concentrations in environmental media were simulated using a multimedia environmental fate model, and converted to contamination levels in exposure media. the risk characterization in this study was based on a ...	2009	19211125
integrative therapies in hospice and home health: introduction and adoption.	integrative therapies comprise a variety of nonpharmacologic methods that provide pain and symptom management. these therapies are increasingly gaining acceptance in the healthcare community as complementary to traditional treatments for pain. this article details the introduction, scope, and challenges healthcare organizations face when incorporating integrative therapies into their care plans.	2009	19212218
prognostic impact of human epidermal growth factor-like receptor 2 and hormone receptor status in inflammatory breast cancer (ibc): analysis of 2,014 ibc patient cases from the california cancer registry.	inflammatory breast cancer (ibc) is an aggressive form of breast cancer associated with overexpression of her2/neu (human epidermal growth factor-like receptor 2 (her2)) and poor survival. we investigated survival differences for ibc patient cases based on hormone receptor status and her2 receptor status using data from the california cancer registry, as contrasted with locally advanced breast cancer (labc), metastatic breast cancer (mbc) and non-t4 breast cancer.	2009	19228416
storm drains are sources of human fecal pollution during dry weather in three urban southern california watersheds.	coastal urbanized areas in southern california experience frequent beach water quality warnings in summer due to high concentrations of fecal indicator bacteria (fib). remediation can be difficult, as sources are often unknown. during two summers, we sampled three urbanized watersheds in santa barbara, ca at sites with historically high fib concentrations to determine if human fecal matter was influencing water quality. by quantification of a human-specific bacteroides marker (hbm), human waste ...	2009	19238954
courts. man denied release from hospital partly due to hiv delusions.		2009	19255979
evaluation of a human on-site urine multidrug test for emergency use with dogs.	a rapid, human on-site urine multidrug test was used to screen canine urine samples for the presence of five illegal drugs and drugs from three commonly abused drug classes. each sample was sent to a toxicology laboratory for gas chromatography/mass spectrometry (gc/ms) validation. on-site test results and gc/ms assays confirmed that the human on-site test kit did identify barbiturates, opiates, benzodiazepines, and amphetamines/methamphetamines in urine from dogs that had received these common ...	2009	19258416
methicillin-resistant staphylococcus aureus skin infections from an elephant calf--san diego, california, 2008.	methicillin-resistant staphylococcus aureus (mrsa) infections are a major cause of human skin and soft tissue infections in the united states. mrsa colonization and infection also have been observed in turtles, bats, seals, sheep, rabbits, rodents, cats, dogs, pigs, birds, horses, and cattle, and mrsa infections with an epidemiologic link to animal contact have been reported in veterinary personnel, pet owners, and farm animal workers. on january 29, 2008, the county of san diego health and huma ...	2009	19265780
parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of california.	evidence from animal and cell models suggests that pesticides cause a neurodegenerative process leading to parkinson's disease (pd). human data are insufficient to support this claim for any specific pesticide, largely because of challenges in exposure assessment. the authors developed and validated an exposure assessment tool based on geographic information systems that integrated information from california pesticide use reports and land-use maps to estimate historical exposure to agricultural ...	2009	19270050
cyp1a1/2 haplotypes and lung cancer and assessment of confounding by population stratification.	prior studies of lung cancer and cyp1a1/2 in african-american and latino populations have shown inconsistent results and have not yet investigated the haplotype block structure of cyp1a1/2 or addressed potential population stratification. to investigate haplotypes in the cyp1a1/2 region and lung cancer in african-americans and latinos, we conducted a case-control study (1998-2003). african-americans (n = 535) and latinos (n = 412) were frequency matched on age, sex, and self-reported race/ethnic ...	2009	19276377
sex differences in humeral bilateral asymmetry in two hunter-gatherer populations: california amerinds and british columbian amerinds.	this study uses two prehistoric amerindian populations of hunter-gatherer subsistence patterns to determine whether levels of sexual dimorphism in humeral bilateral cross-sectional asymmetry are related to sex-specific differences in activities among these populations. results confirmed that males of the california amerind population who engaged in the more unimanual activities of spear hunting and warfare were more asymmetrical than were their female counterparts who engaged in the more bimanua ...	2009	19280674
reptile infection with anaplasma phagocytophilum, the causative agent of granulocytic anaplasmosis.	granulocytic anaplasmosis (ga) is a potentially fatal tick-borne rickettsial disease that occurs sporadically in the far western united states. we evaluated the prevalence of anaplasma phagocytophilum in multiple species of lizards and snakes from enzootic sites in northern california, described the infestation prevalence of its tick vector ixodes pacificus on reptiles, and conducted an experimental challenge of western fence lizards (sceloporus occidentalis) and pacific gopher snakes (pituophis ...	2009	19281295
one in four california adolescent girls have had human papillomavirus vaccination.		2009	19288623
resuscitation of likely nonviable newborns: would neonatology practices in california change if the born-alive infants protection act were enforced?	the effects of the born-alive infants protection act of 2002, which defines the legal status of live-born infants have not been evaluated.	2009	19336366
long-term historical analysis of benthic communities and physical habitat in an agricultural stream in california's san joaquin river watershed.	this study was designed to characterize long-term annual temporal and spatial trends (2001 to 2007) in physical habitat and benthic communities and to determine relationships of habitat and benthic communities during this 7-year period in an agricultural stream in the san joaquin river watershed in california (del puerto creek). the canonical discriminant analysis indicated that there were no overall significant temporal patterns for the habitat metrics although spatial patterns were prominent f ...	2009	19337917
dispersion of response times reveals cognitive dynamics.	trial-to-trial variation in word-pronunciation times exhibits 1/f scaling. one explanation is that human performances are consequent on multiplicative interactions among interdependent processes-interaction dominant dynamics. this article describes simulated distributions of pronunciation times in a further test for multiplicative interactions and interdependence. individual participant distributions of approximately 1,100 word-pronunciation times were successfully mimicked for each participant ...	2009	19348544
swine influenza a (h1n1) infection in two children--southern california, march-april 2009.	on april 17, 2009, cdc determined that two cases of febrile respiratory illness occurring in children who resided in adjacent counties in southern california were caused by infection with a swine influenza a (h1n1) virus. the viruses from the two cases are closely related genetically, resistant to amantadine and rimantadine, and contain a unique combination of gene segments that previously has not been reported among swine or human influenza viruses in the united states or elsewhere. neither chi ...	2009	19390508
ecology of anaplasma phagocytophilum infection in gray foxes (urocyon cinereoargenteus) in northwestern california.	although granulocytic anaplasmosis, caused by infection of anaplasma phagocytophilum, is an emerging human and domestic animal disease, the ecology and natural history of the parasite is not well understood. gray foxes (urocyon cinereoargenteus) are relatively common, occasionally peri-urban mesocarnivores whose geographic distribution overlaps the reported distribution of granulocytic anaplasmosis in humans and domestic animals in north america. we evaluated the potential of foxes as hosts and ...	2009	19395744
availability of hiv postexposure prophylaxis services in los angeles county.	postexposure prophylaxis after sexual exposure to human immunodeficiency virus (hiv) is recommended by state and national agencies. a cross-sectional survey of 117 los angeles county sites found that 17 sites (14.5%) offer postexposure prophylaxis. ten sites (8.5%) offer postexposure prophylaxis to patients who are uninsured. general availability of postexposure prophylaxis should be a public health priority.	2009	19400685
update: infections with a swine-origin influenza a (h1n1) virus--united states and other countries, april 28, 2009.	since april 21, 2009, cdc has reported cases of respiratory infection with a swine-origin influenza a (h1n1) virus (s-oiv) transmitted through human-to-human contact. this report updates cases identified in u.s. states and highlights certain control measures taken by cdc. as of april 28, the total number of confirmed cases of s-oiv infection in the united states had increased to 64, with cases in california (10 cases), kansas (two), new york (45), ohio (one), and texas (six). cdc and state and l ...	2009	19407737
update: drug susceptibility of swine-origin influenza a (h1n1) viruses, april 2009.	since april 21, 2009, cdc has reported cases of respiratory infection with a swine-origin influenza a (h1n1) virus (s-oiv) that is being spread via human-to-human transmission. as of april 28, the total number of confirmed s-oiv cases in the united states was 64; these cases occurred in california (10 cases), kansas (two), new york (45), ohio (one), and texas (six). the viruses contain a unique combination of gene segments that had not been reported previously among swine or human influenza viru ...	2009	19407738
update: swine influenza a (h1n1) infections--california and texas, april 2009.	on april 21, 2009, cdc reported that two recent cases of febrile respiratory illness in children in southern california had been caused by infection with genetically similar swine influenza a (h1n1) viruses. the viruses contained a unique combination of gene segments that had not been reported previously among swine or human influenza viruses in the united states or elsewhere. neither child had known contact with pigs, resulting in concern that human-to-human transmission might have occurred. th ...	2009	19407739
changes in sediment and organic carbon accumulation in a highly-disturbed ecosystem: the sacramento-san joaquin river delta (california, usa).	we used the sacramento-san joaquin river delta ca (delta, hereafter) as a model system for understanding how human activities influence the delivery of sediment and total organic carbon (toc) over the past 50-60 years. sediment cores were collected from sites within the delta representing the sacramento river (sac), the san joaquin river (sjr), and franks tract (ft), a flooded agricultural tract. a variety of anthropogenic tracers including (137)cs, total dde (sigma dde) and brominated diphenyl ...	2009	19409575
the 'millionaires tax' and mental health policy in california.	despite long-standing and widespread opposition to new taxes, in 2004 californians approved a so-called millionaires tax, levied on those with taxable net income over $1 million. the proceeds, estimated to be $700 million to $1 billion per year, can only be spent on improving mental health services for people with or at risk of a disabling mental disorder. progress has been made in access to services, prevention programs, supported housing, and integrating mental health with the other human serv ...	2009	19414891
accuracy and precision of the volume-concentration method for urban stormwater modeling.	land use based models have been widely used to estimate stormwater pollutant loads for establishing standards and selecting best management practices. land use information is required to assign imperviousness or runoff coefficients and event mean concentrations for selected pollutants to the areas of the watersheds. this approach is useful to estimate the total mass discharges, but is dependent on various assumptions for parameters, which have rarely been validated with full-scale field data. th ...	2009	19439339
hydroxylated pcb metabolites (oh-pcbs) in archived serum from 1950-60s california mothers: a pilot study.	we are studying participants selected from the child health and development studies (chds), a longitudinal birth cohort of over 20,000 california pregnancies between 1959 and 1967, for associations between maternal body burden of organochlorine contaminants and thyroid function. we designed a pilot study using 30 samples selected among samples with high and low pcb concentrations to evaluate the feasibility of measuring oh-pcbs in the larger study population. gc-ecd and gc-nci/ms were used to de ...	2009	19439357
swine-origin influenza a (h1n1) virus infections in a school - new york city, april 2009.	on april 24, 2009, cdc reported eight confirmed cases of swine-origin influenza a (h1n1) virus (s-oiv) infection in texas and california. the strain identified in u.s. patients was confirmed by cdc as genetically similar to viruses subsequently isolated from patients in mexico. since april 24, the number of cases in the united states and elsewhere has continued to rise. as of april 28, approximately half (45) of all u.s. cases of s-oiv infection had been confirmed among students and staff member ...	2009	19444151
tumor markers and rectal cancer: support for an inflammation-related pathway.	inflammation may be a key element in the etiology of colorectal cancer. in our study, we examine associations between factors related to inflammation and specific rectal cancer mutations. a population-based study of 750 rectal cancer cases with interview and tumor dna were compared to 1,205 population-based controls. study participants were from utah and the northern california kaiser permanente medical care program. tumor dna was analyzed for tp53 and kras2 mutations and cpg island methylator p ...	2009	19452524
migration patterns of the emerging plant pathogen phytophthora ramorum on the west coast of the united states of america.	phytophthora ramorum (oomycetes) is the causal agent of sudden oak death and ramorum blight on trees, shrubs, and woody ornamentals in the forests of coastal california and southwestern oregon and in nurseries of california, oregon, and washington. in this study, we investigated the genetic structure of p. ramorum on the west coast of the united states, focusing particularly on population differentiation potentially indicative of gene flow. in total, 576 isolates recovered from 2001 to 2005 were ...	2009	19453234
monitoring habitat preserves in southern california using high spatial resolution multispectral imagery.	habitat preserve systems have been established adjacent to the densely populated regions of southern california to support indigenous plant and animal species that are listed as rare, threatened, or endangered. monitoring the condition of habitat across these broad preserves is necessary to ensure their long-term viability and may be effectively accomplished using remote sensing techniques with high spatial resolution visible and near-infrared (vnir) multispectral imagery. the utility of 1 m spa ...	2009	18500452
preparing for pandemic influenza: california confronts the legal implications.	california department of health services and california distance learning health network collaborated with the california conference of local health officers to produce the pandemic influenza and public health law: what public health departments need to know satellite broadcast and tabletop exercise training. local health officers, county counsels, school superintendents, hospital administrators, and senior decision makers in california planned for ways stakeholders would make legal use of publi ...	2009	18434565
the myth of the normal, average human brain--the icbm experience: (1) subject screening and eligibility.	in the course of developing an atlas and reference system for the normal human brain throughout the human age span from structural and functional brain imaging data, the international consortium for brain mapping (icbm) developed a set of "normal" criteria for subject inclusion and the associated exclusion criteria. the approach was to minimize inclusion of subjects with any medical disorders that could affect brain structure or function. in the past two years, a group of 1685 potential subjects ...	2009	18775497
effects of urban development on ant communities: implications for ecosystem services and management.	research that connects the effects of urbanization on biodiversity and ecosystem services is lacking. ants perform multifarious ecological functions that stabilize ecosystems and contribute to a number of ecosystem services. we studied responses of ant communities to urbanization in the lake tahoe basin by sampling sites along a gradient of urban land development. we sampled ant communities, measured vegetation characteristics, quantified human activities, and evaluated ant-community responses b ...	2009	18778268
potential for the emergence of japanese encephalitis virus in california.	the potential risk for the introduction and establishment of japanese encephalitis virus (jev) within california is described based on the literature. jev is a mosquito-borne arbovirus endemic to asia that when transmitted to humans can lead to japanese encephalitis (je), a disease affecting mostly children with a fatality rate up to 30%. the geographical expansion of jev in asia along with the recent introduction and rapid spread of west nile virus (wnv) across the united states, demonstrates t ...	2009	18973447
assisted reproduction for couples affected by human immunodeficiency virus in california.	survey results demonstrate that the majority of fertility clinics in california are willing to care for couples affected by human immunodeficiency virus (hiv) if legal restrictions are removed. in response to scientific advances and evolving clinical standards, california reversed the limitations placed on the provision of assisted reproduction for hiv-positive men in 2008.	2009	18973880
temporal predictability in food availability: effects upon the reproductive axis in scrub-jays.	florida scrub-jays (aphelocoma coerulescens) in a suburban environment with year-round access to multiple sources of abundant, human-source foods consistently breed earlier each year and have lower baseline levels of circulating corticosterone (cort) than jays in a nearby wildland setting. these findings suggest that food supplies influence cort levels, which in turn may partially determine the timing of reproduction. however, wildland birds with access to high-quality supplemental foods did not ...	2009	18756528
understanding and managing experiential aspects of soundscapes at muir woods national monument.	research has found that human-caused noise can detract from the quality of the visitor experience in national parks and related areas. moreover, impacts to the visitor experience can be managed by formulating indicators and standards of quality as suggested in park and outdoor recreation management frameworks, such as visitor experience and resource protection (verp), as developed by the u.s. national park service. the research reported in this article supports the formulation of indicators and ...	2009	19020928
nicotine withdrawal sensitivity, linkage to chr6q26, and association of oprm1 snps in the smoking in families (smofam) sample.	nicotine withdrawal symptoms are related to smoking cessation. a rasch model has been used to develop a unidimensional sensitivity score representing multiple correlated measures of nicotine withdrawal. a previous autosome-wide screen identified a nonparametric linkage (npl) log-likelihood ratio (lod) score of 2.7 on chromosome 6q26 for the sum of nine withdrawal symptoms.	2009	19959688
southern california drosophila conference: irvine, ca - september 11, 2009.	as has become tradition, this year's southern california drosophila conference was hosted by the developmental biology center (http://dbc.bio.uci.edu/) at the university of california, irvine. on september 11, 2009, speakers from institutions in los angeles, orange, riverside, and san diego counties presented their latest results in an informal and friendly atmosphere and had the opportunity to learn about new resources and facilities, establish collaborations, and network about job openings and ...	2009	19923916
a unified approach to molecular epidemiology investigations: tools and patterns in california as a case study for endemic shigellosis.	shigellosis causes diarrheal disease in humans from both developed and developing countries, and multi-drug resistance is an emerging problem. the objective of this study is to present a unified approach that can be used to characterize endemic and outbreak patterns of shigellosis using use a suite of epidemiologic and molecular techniques. the approach is applied to a california case study example of endemic shigellosis at the population level.	2009	19930709
pulmonary coccidioidomycosis: import illness and the importance of travel history.	a 35-year-old man presented at the outpatient department of pulmonary diseases with fever, rhinitis and coughing. he had recently been on holiday in california. except for a body temperature of 39.7 degrees c there were no other abnormal findings at the physical examination. chest x-ray showed a consolidation in the left upper lobe. under antibiotic treatment his clinical condition deteriorated. coccidioidomycosis was the suspected diagnosis and confirmed by the results of ct scanning and cultur ...	2009	19915230
adherence to screening for hepatocellular carcinoma among patients with cirrhosis or chronic hepatitis b in a community setting.	screening for hepatocellular carcinoma (hcc) has been shown to improve survival via earlier cancer detection. although hcc screening is considered standard of care in the usa, little is known of the adherence to this practice, especially in a community setting.	2009	19876735
factors associated with death or hospitalization due to pandemic 2009 influenza a(h1n1) infection in california.	pandemic influenza a(h1n1) emerged rapidly in california in april 2009. preliminary comparisons with seasonal influenza suggest that pandemic 2009 influenza a(h1n1) disproportionately affects younger ages and causes generally mild disease.	2009	19887665
pre-clinical pharmacology training in a student-centered veterinary curriculum.	the appropriate use of therapeutics is important to both human and animal health. the field of pharmacology is rapidly progressing such that it is impossible to convey to students every possible piece of information they will need to know throughout their veterinary careers. instead, it is more important to train students for lifelong and self-directed learning so that they will be able to adapt to the ever-changing pharmaceutical landscape. western university of health sciences college of veter ...	2009	19861712
update on emerging infections: news from the centers for disease control and prevention. hospitalized patients with novel influenza a (h1n1) virus infection--california, april-may, 2009.		2009	19866495
beyond the "model minority" stereotype: trends in health risk behaviors among asian/pacific islander high school students.	asian/pacific islander (api) students have been stereotyped as the "model minority." the objective of this study was to examine the trends in health risk behaviors among api students who participated in the san diego city schools youth risk behavior survey (yrbs) between 1993 and 2005.	2009	19630868
using behavioral economics to promote physical activity.	behavioral economics is a relatively new field of economics that uses experimental techniques to produce insights about human decision-making. one of its key findings is that people's preferences for actions are not absolute, but rather relative to some anchor point, and can therefore be influenced by changing the anchor. anchor points can be social norms, habits acquired in childhood, or a cultural frame-whether physical activity is presented as fun or as drudgery. physical activity promotion c ...	2009	19632266
growth of breastfed infants.	understanding normal growth for the healthy breastfed infant is an important component of promoting and supporting child health in general and breastfeeding in particular. in this article, we summarize what is known regarding differences in growth between breastfed and formula-fed infants; we describe the development and use of infant growth references and growth standards; we introduce the new world health organization growth velocity standards for early infancy (which provide standards for gai ...	2009	19827923
anatomical image library created.		2009	19831003
effects of dietary fiber, fats, and meat intakes on the risk of barrett's esophagus.	animal and human models suggest associations between fat intake, fiber intake, and the risk of esophageal adenocarcinoma. we evaluated whether these factors may act early in the carcinogenic pathway as a risk factor for barrett's esophagus, a potentially premalignant precursor to esophageal adenocarcinoma using a case-control design within the kaiser permanente, northern california population. incident barrett's esophagus cases (n = 296) were matched to persons with gastroesophageal reflux disea ...	2009	19838934
institutional profile: the university of california pharmacogenomics center: at the interface of genomics, biological mechanisms and drug therapy.	the pharmacogenomics center of the university of california, san francisco (ca, usa) fosters research and educational activities focused on the genomic basis for variation in drug response. investigators in the center conduct multidisciplinary and multicenter research on a diverse array of clinically used drugs with the goal of understanding the genetic factors that contribute to variation in therapeutic and adverse drug response. the center houses the large nih-supported pharmacogenomics of mem ...	2009	19842929
clinical and angiographic results with the next-generation resolute stent system: a prospective, multicenter, first-in-human trial.	the resolute trial examined the safety and efficacy of a next-generation zotarolimus-eluting coronary stent, resolute (medtronic cardiovascular inc., santa rosa, california).	2009	19850258
long-term clinical outcomes following en bloc resections for sacral chordomas and chondrosarcomas: a series of twenty consecutive patients.	retrospective study of 20 consecutive patients who underwent en bloc tumor excision of sacral chordomas and chondrosarcomas.	2009	19752710
tensaw virus genome sequence and its relation to other bunyaviridae.	tensaw virus (tsv) belongs to the genus orthobunyavirus within the bunyaviridae family. although tsv does not cause hemorrhagic fever as some other members of its family, serological studies have shown that serum from florida residents react against tsv indicating viral infection in humans. in this study, the three rna genome segments of a tsv isolated from anopheles crucians mosquitoes collected in north central florida in 2006 and a tsv isolate obtained from the cdc, fort collins, were sequenc ...	2009	19760176
the university of california center for the environmental implications of nanotechnology.	assessing nanomaterialsfor human health and ecotoxicological impact can be well aided by using high-throughput laboratory methods.	2009	19764201
truths and myths that influence the sexual decision-making process among young multiethnic college women.	in the united states, half of all new human immunodeficiency virus (hiv) cases are among 13- to 24-year-old women. heterosexual contact is the primary route of transmission (73%). young african americans account for 56% of reported hiv cases. in an earlier study, s. t. roberts and b. l. kennedy (2006) studied sexual decision making among 100 young multiethnic college women (ymcw). participants reported high condom use intention (84%) but inconsistent condom use (64%). participants perceived thei ...	2009	19766928
effect of prescribed fire for tick control in california chaparral.	prescribed fire was investigated as a method for controlling ixodid and argasid ticks in chaparral habitats in northern california. two experimental and two adjacent control plots within a wildlife preserve were monitored for 1 yr postburn. ticks were collected by flagging vegetation, by co2-baited pitfall trap, and by live-trapping rodents. twice as many rodents were caught at control sites compared with burn sites and no dusky-footed woodrats, neotoma fuscipes baird, were found in the treatmen ...	2009	19769046