Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| assimilation of ammonia and growth of biotin deficient aspergillus nidulans. | biotin deficiency in aspergillus nidulans has been found to increase the uptake of ammonium ions, associated with a marked increase in the activity of nadp-linked glutamate dehydrogenase, which is found to be the major route of ammonia assimilation in this culture. the results obtained are discussed with respect to the growth of aspergillus nidulans during biotin deficiency. | 1976 | 5283 |
| chlorate toxicity in aspergillus nidulans. studies of mutants altered in nitrate assimilation. | it had previously been held that chlorate is not itself toxic, but is rendered toxic as a result of nitrate reductase-catalysed conversion to chlorite. this however cannot be the explanation of chlorate toxicity in aspergillus nidulans, even though nitrate reductase is known to have chlorate reductase activity. among other evidence against the classical theory for the mechanism of chlorate toxicity, is the finding that not all mutants lacking nitrate reductase are clorate resistant. both chlorat ... | 1976 | 8697 |
| effect of the area gene on regulation of arginine catabolism in aspergillus nidulans. | the area gene which is known to be involved in ammonium repression in aspergillus nidulans was found to participate in regulation of arginine catabolism. mutations in this gene are hypostatic to mutations in arca, sudpro and suepro genes which are responsible for regulation of synthesis of arginine catabolic enzymes. | 1976 | 62492 |
| atmospheric mutagens. i. sulfur oxides and nitrogen oxides. | 1976 | 134284 | |
| adenosine triphosphatase of aspergillus nidulans: effect of growth temperature. | 1976 | 140148 | |
| the effect of glucose and manganese on adenosine-3',5'-monophosphate levels during growth and differentiation of aspergillus nidulans. | the role of cyclic adenosine monophosphate (camp) during growth and development of aspergillus nidulans was investigated. in normal cultures the highest amount of camp, expressed on a dry weight basis, was found after 24 h of growth when still more than 5% glucose was present in the medium. after depletion of the medium even a slight fall in camp was noted. glucose concentrations ranging from 0.5-12% resulted in a slight decrease in the amount of camp as measured after 24 h of growth. cultures w ... | 1976 | 179489 |
| mutants of aspergillus nidulans lacking nicotinamide adenine dinucleotide-specific glutamate dehydrogenase. | ten mutants of aspergillus nidulans lacking nicotinamide adenine dinucleotide-specific glutamate dehydrogenase (nad-gdh) have been isolated, and their mutations (gdhb1 through gdhb10) have been shown to lie in the gdhb gene. in addition, a temperature-sensitive gdhb mutant (gdhb11) has been isolated. a revertant (designated r-5) of the mutant gdhb1 bears an additional lesion in the gdhb gene and has altered nad-gdh activity with altered km values for ammonia or ammonium ions and for alpha-ketogl ... | 1976 | 173707 |
| formation in the dark, of virus-induced deoxyribonuclease activity in anacystis nidulans, an obligate photoautotroph. | in anacystis nidulans, upon infection with cyanophage as-1, after a lag period of 1 h the level of deoxyribonuclease (dnase) activity increaded rapidly up to 15- to 20-fold in 4 to 5 h in the light. in contrast, the ribonuclease and phosphomonoesterase activities increased significantly only 4 to 5 h after infection, i.e. as late as 1 h prior to lysis. in complete darkness, the nuclease levels remained unaltered. however, when the infected cells were exposed to light for 1 or 2 h after infection ... | 1976 | 177400 |
| mitotic crossing over and nondisjunction in translocation heterozygotes of aspergillus. | to analyze mitotic recombination in translocation heterozygotes of a. nidulans two sets of well-marked diploids were constructed, homo- or heterozygous for the reciprocal translocations t1 (il;viir) or t2 (il;viir) and heterozygous for selective markers on il. it was found that from all translocation heterozygotes some of the expected mitotic crossover types could be selected. such crossovers are monosomic for one translocated segment and trisomic for the other and recovery depends on the relati ... | 1976 | 773747 |
| chloral hydrate induced haploidization in aspergillus nidulans. | this is the first report of induction of haploidization in aspergillus nidulans by chloral hydrate, which is an efficient polyploidizing agent for higher plants and a psychotropic drug for man. a new procedure has been described to isolate haploids from diploids with a very high frequency, as compared to p-fluorophenylalanine, which is generally used for this purpose. | 1976 | 786720 |
| fungal infections after renal transplantation. | fungal infections occurred in 3 of 22 renal transplants (13.6%). two patients developed rhinocerebral phycomycosis, and rhizopus arrhizus was isolated from cultures of the nasal conchae. both patients were treated with systemic amphotericin b. three-and-a-half months after transplantation the third patient developed an acute ureteral obstruction secondary to infection with aspergillus nidulans; this necessitated removal of the graft. there was no immediate mortality associated with these fungal ... | 1976 | 786944 |
| the genetic instability and mutagenic interaction of chromosomal duplications present together in haploid strains of aspergillus nidulans. | previous work has shown that strains of aspergillus nidulans with a chromosome segment in duplicate (one in normal position, one translocated to another chromosome) are unstable. deletions occur from either duplicate segment. the present work has shown that when a chromosome i duplication and a chromosome iii duplication are together in a haploid, deletions from the intact iii duplication generally precede deletions from particular sections of the i duplication. furthermore, the iii duplication ... | 1976 | 787776 |
| cytochrome abnormalities and cyanide-resistant respiration in extranuclear mutants of aspergillus nidulans. | the cytochrome spectra of two extranuclear mutants of aspergillus nidulans and the double-mutant recombinant formed from them have been examined both at room temperature and at the temperature of liquid n2 and compared with those of the wild-type strain. the oligomycin-resistant, slow growing mutant contained an increased amount of cytochrome c without any loss of cytochromes b and a,a3. the cold-sensitive mutant, apparently normal when grown at 37 c, showed an increased amount of cytochrome c a ... | 1976 | 1107321 |
| [a genetic transfer system in a cyanophyte of the genus aphanocapsa]. | the possibility of a genetic transfer, through a process of transformation, has been shown in a unicellular, facultative chemoheterotroph blue-green algae, aphanocapsa 6714. similarly to the process described with anacystis nidulans, the recipient strain becomes competent when the growth reaches its second, slower, exponential phase. the genetic marker conferring resistance to p-f-phenylalanine has been transferred with a frequency 20 to 100 times higher than that of the spontaneous mutations. t ... | 1976 | 817846 |
| isolation and characterization of a cyanophage infecting the unicellular blue-green algae a. nidulans and s. cedrorum. | 1976 | 821247 | |
| functional 70s hybrid ribosomes from blue-green algae and bacteria. | hybrid 70s ribosomes were produced by combing anacystis nidulans and escherichia coli 30s and 50s subunits. both the a. nidulans 30se. coli 50s and e. coli 30s- a. nidulans 50s hybrids were functional in synthesizing protein when tested in a standard in vitro amino acid incorporating system. both 70s hybrids were inhibited by streptomycin but the degree of inhibition was dependent upon the source of the 30s subunit. the ability to form functional 70s ribosomes from subunits of blue-green algae a ... | 1976 | 822798 |
| genetics of biosynthesis and overproduction of penicillin. | 1976 | 823642 | |
| [action of various beta(1-3)-d-glucanases on the wall of yeasts: taxonomic applications]. | purified beta-(1-3)-d-glucanases (from aspergillus nidulans, badidiomycetes sp. qm 806, trichoderma viride) are used to release protoplasts from various yeasts. two of them may prove taxonomic correlation. the enzyme of basidomycetes sp. releases protoplasts from ascomycetes, the enzyme of t. viride releases protoplasts from ascomycetes and heterobasidiomycetes; none of them acts on the basidiomycetes. | 1976 | 826331 |
| role of nicotinic acid in pyridoxine biosynthesis in aspergillus nidulans. | 1976 | 999690 | |
| the effects of temperature on genetic instability in aspergillus nidulans. | previous work has shown that strains of aspergillus nidulans with a chromosome segment in duplicate (one in normal position, one translocated to another chromosome) are unstable. deletions occur from either duplicate segment. the present work has shown that most deletions occur from the translocated duplicate segment. furthermore, it has been found that the overall frequency of deletions from a duplication is dependent upon the temperature of growth. the overall frequency of deletions from a chr ... | 1976 | 765807 |
| hyper-repressible operator-type mutant in sulphate permease gene of aspergillus nidulans. | 1976 | 765839 | |
| a temperature-sensitive mutant of aspergillus nidulans reversibly blocked in nuclear division. | 1976 | 767122 | |
| initial characterization of aspergillus nidulans mutants blocked in the nuclear replication cycle. | several hundred temperature-sensitive mutants of aspergillus nidulans were screened for ability of their conidia to produce germ tubes at the nonpermissive temperature while still remaining with the original single conidial nucleus. | 1976 | 770457 |
| determination of the execution points of mutations in the nuclear replication cycle of aspergillus nidulans. | cultures of nuclear replication cycle mutants of aspergillus nidulans were transferred to the nonpermissive temperature, and the fraction of nuclei still able to reach mitosis was determined. for the determinations, benomyl [methyl-1(butylcarbomoyl)benzimidazolecarbamate] was added to trap nuclei in mitosis, and these were detected by staining with aceto-orcein. the assumptions and controls required to relate the experimentally determined fractions to the points where a mutation blocks the nucle ... | 1976 | 770458 |
| tubulin-like protein from aspergillus nidulans. | 1976 | 773373 | |
| cholorate toxicity in aspergillus nidulans: the selection and characterisation of chlorate resistant mutants. | mutation in at least ten genes can result in chlorate reistance in aspergillus nidulans. mutation in seven of these genes also results in the inability to use nitrate as nitrogen source. the various classes of resistant mutant obtained occur in different proportions, depending on whether or not a mutagenic treatment is employed, and also on which nitrogen source is used for selection. the prinicipal effect of mutagen arises because mutations in the niad gene, the nitrate reductase structural gen ... | 1976 | 773908 |
| well-marked strains of aspergillus for tests of environmental mutagens: identification of induced mitotic recombination and mutation. | 1976 | 775325 | |
| mutants of aspergillus nidulans lacking pyruvate kinase. | 1976 | 776698 | |
| the isolation of nuclei from the filamentous fungus aspergillus nidulans. | a method has been developed for isolating nuclei from the filamentous fungus aspergillus nidulans. in this procedure, the mycelia from 14 to 16 h spore-derived cultures of a. nidulans nri, a stable diploid strain, were frozen with liquid nitrogen and homogenized in a waring blender. after homogenization, the mycelia were warmed to 4 degrees c and the nuclei were purified from the homogenate by differential centrifugation followed by sedimentation through 2.1 m-sucrose. the final nuclear yield wa ... | 1976 | 778331 |
| effect of glucose, ammonium and media maintenance on the time of conidiophore initiation by surface colonies of aspergillus nidulans. | 1976 | 778332 | |
| agar as a carbon source and its effect on the utilization of other carbon sources by acetate non-utilizing (acu) mutants of aspergillus nidulans. | 1976 | 778333 | |
| integrator gene in aspergillus nidulans. | 1976 | 778641 | |
| enhancement of tissue invasion in murine aspergillosis by systemic administration of suspensions of killed corynebacterium parvum. | the effect of killed corynebacterium parvum vaccine on the course of murine aspergillosis is described. a grid-counting technique was employed to quantitate tissue invasion by aspergillus nidulans in the brain, heart, and kidneys (the target organs) of normal mice and of mice treated systemically with killed c. parvum vaccine. simultaneous treatment of mice with c. parvum and a. nidulans significantly increased the mortality rate, in contrast to treatment of mice with c. parvum prior to or follo ... | 1976 | 779492 |
| proceedings: influence of microwaves on genetical processes of aspergillius nidulans. | 1976 | 781259 | |
| partial purification of methionine binding protein from aspergillus nidulans by affinity chromatography. | 1976 | 782531 | |
| nucleosome structure in aspergillus nidulans. | the structure of chromatin from aspergillus nidulans was studied using micrococcal nuclease and dnaase i. limited digestion with micrococcal nuclease revealed a nucleosomal repeat of 154 base pairs for aspergillus and 198 base pairs for rat liver. with more extensive digestion, both types of chromatin gave a similar quasi-limit product with a prominent fragment at 140 base pairs. the similarity of the two limit digests suggests that the structure of the 140 base pair nucleosome core is conserved ... | 1976 | 782724 |
| polyamine and ornithine metabolism during the germination of conidia of aspergillus nidulans. | 1. the activities of ornithine decarboxylase, s-adenosylmethionine decarboxylase and ornithine-2-oxoglutarate aminotransferase were studied during the first 24 h of conidial germination in aspergillus nidulans. 2. increases (over 100-fold) in the activities of ornithine decarboxylase and s-adenosylmethionine decarboxylase occurred during the emergence of the germ-tube and before the doubling of dna and this was followed by a sharp fall in the activities of both enzymes by 16h. 3. the increase in ... | 1976 | 791270 |
| [dna degradation induced by radiation in aspergillus nidulans]. | 1976 | 791383 | |
| phosphorus uptake in biotin deficient aspergillus nidulans: an evidence for the involvement of binding protein in this process. | 1976 | 791857 | |
| relationship of the genetic determination of impaired penicillin production in naturally occurring strains to that in induced mutants of aspergillus nidulans. | 1976 | 792389 | |
| estimation of the generation time and peripheral growth zone of aspergillus nidulans and alternaria solani hyphae from radial growth rates and ranges in apical cell length. | 1976 | 792392 | |
| purification of a deoxyribonuclease from aspergillus nidulans. | 1976 | 793906 | |
| mitosis, septation, branching and the duplication cycle in aspergillus nidulans. | mitosis, septation and branching were studied in undifferentiated mycelia and leading hyphae of aspergillus nidulans, a mould which forms incomplete septa. after spore germination, nuclei divided synchronously until germ-tube hyphae contained 8 or 16 nuclei; mitosis occurred when the volume of cytoplasm per haploid nucleus was about 60 mum3. intercompartment development was not synchronized, consequently mitosis in the mycelium as a whole eventually became asynchronous. during the stage of async ... | 1976 | 796408 |
| formation of nadph-nitrate reductase activity in vitro from aspergillus nidulans niad and cnx mutants. | mutants of a. nidulans at several loci lack detectable nadph-nitrate reductase activity. these loci include niad, the structural gene for the nitrate reductase polypeptide, and five other loci termed cnxabc, e, f, g and h which are presumed to be involved in the formation of a molybdenum-containing component (mcc) necessary for nitrate reductase activity. when forzen mycelia from a. nidulans deletion mutant niad26 were homogenized in a ten broeck homogenizer together with frozen mycelia from eit ... | 1976 | 796678 |
| panel discussion on submammalian systems. | 1976 | 796705 | |
| synthesis of polyamines in the germinating conidia of aspergillus nidulans. | 1976 | 798705 | |
| the effects of putrescine, spermidine, and spermine on the growth of a polyamine-requiring mutant of aspergillus nidulans. | 1976 | 798706 | |
| presence of histones in aspergillus nidulans. | five major histone proteins have been extracted from chromatin isolated from purified nuclei of the fungus, aspergillus nidulans. these proteins had chromatographic properties which were similar to reference calf thymus histones and were purified to electrophoretic homegeneity by gel chromatography of bio-gel p10, bio-gel p60, and sephadex g-100. electrophoresis of these proteins in three different systems (urea-starch, urea-acetic acid polyacrylamide, and discontinuous sds polyacrylamide) showe ... | 1976 | 799641 |
| choline-o-sulphate utilization in aspergillus nidulans. | 1976 | 800000 | |
| maternal inheritance of extranuclear mitochondrial markers in aspergillus nidulans. | 1976 | 800001 | |
| tumor induction by a single subcutaneous injection of sterigmatocystin in newborn mice. | sterigmatocystin, a mycotoxin produced by aspergillus versicolor, aspergillus sydowi, aspergillus nidulans, and a species of bipolaris, was given to newborn balb/c x dba/2f1 (hereafter referred to as cd2f1) mice by a single s.c. administration in 1% gelatin suspension. in an acute toxicity study, the maximum tolerated dose of sterigmatocystin was 5 mug/g body weight. in a chronic study, a single s.c. injection of 5, 1, or 0.5 mug/g body weight gave rise to high incidences of lung and liver adeno ... | 1976 | 1268822 |
| the reconstitution of anacystis nidulans dna-dependent rna polymerase from its isolated subunits. | the dna-dependent rna polymerase of the blud-green alga anacystis nidulans was reconstituted from its isolated subunits in the absence of urea. applying this technique the kinetics and the subunit requirements of the reconstitution process were analyzed. the results reveal differences with respect to the reconstitution of escherichia coli polymerase. reconstitution proceeds much more slowly in the case of the a. nidulans enzyme. reconstitution here is absolutely dependent on the presence of the ... | 1976 | 814000 |
| uv mutagenesis in inhibitor depleted conidia of aspergillus nidulans. | uv treated conidia of a strain of aspergillus nidulans (meth gl. bial) depleted of germination inhibitory substances have been examined for inactivation and mutation induction at groups of suppressor gene loci defining three classes of methionine revertants. an exponential decline in the colony forming ability and quadratic increase in mutation frequency (for each class of revertant) as the incident dose increased were observed. the induced mutation frequency for each class and the loss of colon ... | 1976 | 14997599 |
| metabolism of delta-aminolevulinic acid in red and blue-green algae. | delta-aminolevulinic acid was incorporated in vivo into c-phycocyanin and b-phycoerythrin in two species of the rhodophyta (cyanidium caldarium, porphyridium cruentum) and three species of the cyanophyta (anacystis nidulans, plectonema boryanum, phormidium luridum). amino acid analysis of phycocyanin-(14)c from c. caldarium cells which had been incubated with delta-aminolevulinate-4-(14)c showed that 84% of the radioactivity incorporated was present in the phycocyanobilin chromophore and less th ... | 1975 | 16659103 |
| counterimmunoelectrophoresis in the diagnosis of mycetoma and its sensitivity as compared to immunodiffusion. | counterimmunoelectrophoresis used for the diagnosis of mycetoma was found superior to immunodiffusion (id) especially when using neat serum and 1:2 dilution (p=less than 0.0001 with neat serum; and less than 0.01 with 1:2 dilution). it is recommended for routine use in mycology laboratories for following up patients on treatment and for confirming the diagnosis of sera that are weakly positive by id. | 1975 | 817400 |
| the inheritance of penicillin titre in wild-type isolates of aspergillus nidulans. | in a sample of 52 wild-type isolates of aspergillus nidulans, penicillin titre ranged from 0-0 to 14-4 units/ml. these differences in titre were under genetic control. most of the variation between isolates was attributable to differences between heterokaryon-compatibility groups although significant differences were also found within groups. genetic variation for penicillin titre was observed among the progeny in four of seven crosses between wild-type isolates. in these four crosses the variat ... | 1975 | 803549 |
| the design of fermentation and biological assay procedures for assessment of penicillin production in populations of aspergillus nidulans. | 1975 | 805120 | |
| the fine structure of the branched alpha-d-glucan from the blue-green alga anacystis nidulans: comparison with other bacterial glycogens and phytoglycogen. | the fine structure of the glycogen from the blue-green alga anacystis nidulans has been examined. after selective hydrolysis of all (1 yields 6)-alpha-d linkages by a bacterial isoamylase, the resulting mixture of linear chains was subjected to gel permeation chromatography. for purposes of comparison, the glycogens from escherichia coli and arthrobacter sp., amylopectin, phytoglycogen from sweet corn, and shell-fish glycogen were treated similarly. the profiles of the unit chains of a nidulans ... | 1975 | 806344 |
| labeling the deoxyribonucleic acid of anacystis nidulans. | analysis of cell-free extracts of anacystis nidulans disclosed the absence of both thymidine phosphorylase (ec 2.4.2.4) and thymidine kinase (ec 2.7.1.21) activities. thymine and thymidine were incorporated inefficiently by intact cells of a. nidulans either in the presence or absence of deoxyguanosine (250 mug/ml). deoxythymidine monophosphate incorporation was also inefficient. radioactive deoxyadenosine, at a minimally toxic level (3 mug/ml), was incorporated effectively into the deoxyribonuc ... | 1975 | 809413 |
| sequence studies on 16s ribosomal rna from a blue-green alga. | the 16s ribosomal rna of the blue green alga anacystis nidulans has been characterized in terms of the oligomers generated by digestion with t1 ribonuclease. a. nidulans by this criterion is definitely a procaryote; being no more distant from bacilli or enterics than the latter two are from one another. a. nidulans appears to be somewhat more closely related to the bacilli than to the enterics. | 1975 | 813006 |
| hemolytic, cytotoxic and complement inactivating properties of extracts of different species of aspergillus. | some of the biological properties of saline extracts of the mycelia of several species of the aspergillus genus, namely, a. fumigatus, a. flavus, a. niger, a. nidulans, a. parasitucus and a. glaucus, were studied. only the extract prepared from a. fumigatus was found to be hemolytic for sheep red blood cells. in contrast, all the extracts with the only exception of that of a. glaucus, had cytotoxic effects on vero cells. both, the hemolytic and cytotoxic constituents of the extracts were removab ... | 1975 | 813147 |
| [thermosensitive lethal mutants in aspergillus nidulans]. | 1975 | 785156 | |
| acquired resistance to benzimidazole derivatives. | 1975 | 773644 | |
| mitochondrial dna from aspergillus nidulans. | 1975 | 773682 | |
| subcellular mislocation of cysteine synthase in a cysteine auxotroph of aspergillus nidulans. | 1975 | 773683 | |
| ornithine decarboxylase activity in germinating conidia of aspergillus nidulans. | 1975 | 773695 | |
| altered instability due to genetic changes in a duplication strain of aspergillus nidulans. | 1975 | 767217 | |
| role of organic phosphates in the formation of phosphatases in aspergillus nidulans. | 1975 | 767255 | |
| a cis-dominant regulatory mutation affecting enzyme induction in the eukaryote aspergillus nidulans. | 1975 | 1089206 | |
| increased fusion frequency of aspergillus nidulans protoplasts. | 1975 | 1089544 | |
| glucose uptake by aspergillus nidulans, purification and properties of glucose binding protein. | 1975 | 1089548 | |
| mutations which affect amino acid transport in aspergillus nidulans. | mutants deficient in amino acid transport (aau), and unable to utilize l-glutamate as a sole carbon and nitrogen source, have been isolated. there are four unlinked genes involved: aaua, aaub, aauc and aaud. the transport levels of certain amino acids, and the growth characteristics on certain nitrogen and carbon sources and toxic amino acid analogues, indicate that: aauai has defective transport of acidic amino acids; aaubi has defective transport of acidic and neutral amino acids; aauci and aa ... | 1975 | 1089752 |
| a gene cluster in aspergillus nidulans with an internally located cis-acting regulatory region. | work reported here on the fungus aspergillus nidulans has provided the first definitive demonstration of operon-type organisation in an eukaryote genome. it has been shown that the prna and prnb genes concerned with proline metabolism form a gene cluster with the regulatory region lying between the two putative structural genes prna and prnb. regulatory mutations (prnd) probably leading to relief of carbon catabolite repression, map in between prna and prnb and are cis-dominant with respect to b ... | 1975 | 1089903 |
| initiator constitutive mutation with an 'up-promoter' effect in aspergillus nidulans. | a mutation leading to strong constitutivity for a uric acid-xanthine permease in the lower eukaryote aspergillus nidulans has been found to be tightly linked to the putative structural gene whose expression it controls in the cis configuration. in addition, it increases the maximal induced level of transport 2.5-fold. this is the first demonstration of an initiator or promoter mutation in an eukaryote. | 1975 | 1089904 |
| autolytic enzymes in hyphae of aspergillus nidulans: their action on old and newly formed walls. | walls, purified from hyphae of the ascomycete aspergillus nidulans, autolyzed on incubation and liberated glucose, mannose, galactose, n-acetylglucosamine, and soluble oligosaccharides. digestion proceeded at linear rates until approximately 3% of the wall polymers had been hydrolyzed and then slowed markedly. the change in the rate of autolysis was not due to loss of enzyme activity but was caused by the disappearance of a fraction of the wall which was highly susceptible to digestion. radioact ... | 1975 | 1090573 |
| keratomycosis in lucknow. | 1975 | 1092323 | |
| reciprocal translocations and translocation disomics of aspergillus and their use for genetic mapping. | two new techniques are described for genetic mapping of reciprocal translocations in a. nidulans, which can be used to locate centromeres and meiotically unlinked markers. they both make use of unbalanced disomics from heterozygous translocation crosses. these are mainly hyperhaploids of two classes: either typical-looking n + 1 with a normal chromosome in addition to a haploid set containing the translocation, or translocation disomics. when large chromosome segments are involved, such disomics ... | 1975 | 1092596 |
| effect of l-histidine on the catabolism of nitrogenous compounds in aspergillus nidulans. | 1975 | 1094095 | |
| nitrate utilization and growth in biotin-deficient aspergillus nidulans. | a marked increase in the cellular synthesis accompanied by a decrease in the total fatty acid content was observed when aspergillus nidulans was grown on nh4no3 as a sole nitrogen source, in the medium containing avidin. because of the increased uptake of nh4(plus), the level of nh4(plus), was lowered in the medium; as a result there is early uptake and assimilation of nitrate by a biotin-deficient culture as compared with the normal culture of a. nidulans. at about 17mm concentration, nh4(plus) ... | 1975 | 1097067 |
| the effect of chloral hydrate upon mitosis in aspergillus nidulans. | 1975 | 1097582 | |
| quantitative tissue invasion of the murine brain as a phenotypic marker of strain virulence in aspergillus nidulans. | in this study the extent of fungal invasion in tissues of the target organs (brain, heart and kidney) has been quantitated histologically in dba/2j mice inoculated intravenously with 3 strains of aspergillus nidulans of different virulence. this was done to determine the relation between tissue invasion and strain virulence as determined by time-mortality bioassay. it was found that quantitatively tissue invasion by a. nidulans was target organ specific. relative tissue invasion within each of t ... | 1975 | 1099700 |
| homolanthionine in fungi: accumulation in the methionine-requiring mutants of aspergillus nidulans. | homolanthionine, a higher homologue of cystathionine, was found to accumulate in the mutants of aspergillus nidulan impaired in the synthesis of methionine from homocysteine. the additional introduction of mutation resulting in a block at cystathionine gamma-synthase but not at cystathionine beta-synthase abolishes accumulation of both homolanthionine and cystathionine. this suggests a possible participation of cystathionine gamma-synthase in homolanthionine synthesis. | 1975 | 1101592 |
| mutants affecting histidine utilization in aspergillus nidulans. | 1975 | 1102388 | |
| an easy way of obtaining aspergillus nidulans haploids in the parasexual cycle using n-glycosyl polifungin. | 1975 | 1102390 | |
| enzymatic lesions in methionine mutants of aspergillus nidulans: role and regulation of an alternative pathway for cysteine and methionine synthesis. | in aspergillus nidulans the pathway involving cystathionine formation is the main one for homocysteine synthesis. mutants lacking cystathionine gamma-synthase or beta-cystathionase are auxotrophs suppressible by: (i) mutations in the main pathway of cysteine synthesis (cysa1, cysb1, and cysc1), (ii) mutations causing stimulation of cysteine catabolism (su101), and (iii) mutations in a presumed regulatory gene (suameth). a relative shortage of cysteine in the first group of suppressors causes a d ... | 1975 | 1102536 |
| mutations affecting mitotic recombination frequency in haploids and diploids of the filamentous fungus aspergillus nidulans. | a haploid strain of asp. nidulans with a chromosome segment in duplicate (one in normal position on chromosome i, one translocated to chromosome ii) shows mitotic recombination, mostly by conversion, in ade in a frequency slightly higher than in the equivalent diploid. a method has been devised, using this duplication, for the selection of rec and uvs mutations. six rec mutations have been found which decrease recombination frequency in the haploid. one mutation selected as uv sensitive showed a ... | 1975 | 1102911 |
| cytoplasmic and nuclear mutations to chloramphenicol resistance in aspergillus nidulans. | two chloramphenicol resistance mutations out of 123 tested in aspergillus nidulans are inherited extranuclearly as judged by transmissibility in heterokaryons, lack of segregation at meiosis, and independent segregation from all of the eight nuclear linkage groups. they do not recombine with each other. however, experiments in collaboration with g. turner and r.t. rowlands show that they do recombine with cytoplasmic mutations to oligomycin resistance (rowlands and turner, 1973) and cold-sensiti ... | 1975 | 1102919 |
| pyrimidine biosynthesis in aspergillus nidulans: isolation and preliminary characterisation of auxotrophic mutants. | 113 pyrimidine auxotrophs, unable to synthesise ump have been selected in aspergillus nidulans. these mutants can be classified by complementation into eight groups, and genetic analysis has shown that five loci are involved. one complex locus consists of the mutually complementing pyra, pyrb and pyrc groups, as well as the cis-dominant pyrn group, members of which do not complement with members of the a, b or c groups. pyra mutants have been shown to lack cpsase-ur, pyrb and pyrc mutants have b ... | 1975 | 1102932 |
| proceedings: fungicides causing mitotic segregation in aspergillus diploids. | 1975 | 1102965 | |
| amide utilization in aspergillus nidulans: evidence for a third amidase enzyme. | a mutation in a gene designated gmda has been found to lead to loss of ability of aspergillus nidulans to use benzamide, phenylacetamide and several other amides as sole nitrogen sources for growth. the gmda1 lesion results in low levels of an enzyme, called the general amidase, which has acitivity for a wide range of amide substrates. this enzyme is reressed by certain nitrogen-containing metabolites, including ammonium, but is probably not regulated by induction or by carbon catabolite repress ... | 1975 | 1104771 |
| studies of partially repressed mutants at the tama and area loci in aspergillus nidulans. | mutants, designated tamar, have been isolated on the basis of simultaneous resistance to toxic analogues thiourea, aspartate hydroxamate and chlorate with l-alanine as the sole nitrogen source. tamar mutants are also resistant to methylammonium. this resistance of tamar mutants is correlated with partially repressed activity of a number of enzyme and transport systems regulated by ammonium. furthermore, tam-ar mutants have low nadp-glutamate dehydrogenase (nadp-gdh) activity and also efflux ammo ... | 1975 | 1105154 |
| sexual differentiation in aspergillus nidulans: the requirement for manganese and its effect on alpha-1,3 glucan synthesis and degradation. | aspergillus nidulans was grown on media with added amounts of manganese ranging from 0--2.5 mum. manganese deficiency prevented cleistothecium development, although good vegetative growth was retained. subsequent analysis of the mycelium produced under mn2+ deficient growth revealed that alpha-1,3 glucan, the man carbon and energy source for fructification, was virtually absent from the cell wall. several enzymes related to cell wall composition were investigated. beta-1,3 glucanase, and very re ... | 1975 | 1106342 |
| formation of 2,4-dihydroxybenzoic acid & resorcinol as intermediates in the degradation of salicylic acid by aspergillus nidulans. | 1975 | 1107218 | |
| hybridization and selection for increased penicillin titre in wild-type isolates of aspergillus nidulans. | repeated hybridization and selection among wild-type isolates produced strains of aspergillus nidulans with increased penicillin titre. four independent selection lines were established, each originating from a sexual cross between two different heterokaryon-incompatible wild-type isolates. in each generation, two selected high-titre sister strains were crossed to produce the next generation. an initial increase in titre was obtained in each line, but after four or five generations of selection ... | 1975 | 1107473 |
| hybridization and selection for increased penicillin titre in wile-type isolates of aspergillus nidulans. | repeated hybridization and selection among wild-type isolates produced strains of aspergillus nidulans with increased penicillin titre. four independent selection lines were established, each originating from a sexual cross between two different heterokaryon-incompatible wild-type isolates. in each generation, two selected high-titre sister strains were crossed to produce the next generation. an initial increase in titre was obtained in each line, but after four or five generations of selection ... | 1975 | 1107474 |
| the inheritance of penicillin titre in crosses between lines of aspergillus nidulans selected for increased productivity. | selection for increased penicillin production among the progeny of pairwise crosses between wild-type isolates of aspergillus nidulans resulted in the production of high-titre strains. three crosses were made between strains with increased titre derived from independent selection lines. significant genetic variation was found among the progeny of each cross, indicating that different genes for increased titre had been selected in each line. gene action was additive in each cross. renewed selecti ... | 1975 | 1107475 |
| genetic control of chromosome instability in aspergillus nidulans as a mean for gene amplification in eukaryotic microorganisms. | a haploid strain of aspergillus nidulans carrying i-ii duplication homozygous for the leaky mutation ade20 shows impreved growth on minimal medium. the duplication, though more stable than disomics, still shows instability. several methods were used for detecting genetic control of improved stability. (a) visual selection, using a duplicated strain which is very unstable due to uv sensitivity, (ade20, bial/dp ya2; uvsb). one stable strain showed a deletion (or a lethal mutation?) distal to bia o ... | 1975 | 1107799 |
| cysteine biosynthesis in aspergillus nidulans. | the existence of two postulated pathways of anabolic cysteine biosynthesis in aspergillus midulans was investigated. no activities of the postulated pathway involving s-sulfocysteine as intermediate have been detected. investigations on cyteine and methionine requiring mutants revealed independent regulation of o-acetylserine sulfhydrylase by endogeneous cysteine and methionine pools. the reaction catalysed by o-acetylserine sulfhydrylase is postulated as the only anabolic pathway of cysteine bi ... | 1975 | 1108603 |
| an unstable strain of aspergillus foetidus segregating proline auxotrophs. | two basic colony types have been obtained through single conidial isolation from the bode strain of aspergillus foetidus as well as from mutants of this unstable strain. type i is prototrophic whereas type ii is an auxotroph requiring proline. when a type i strain is grown on complex medium it gradually becomes overwhelmed by type ii sectors of growth. however, essentially pure cultures of type i can be maintained on minimal medium (lacking proline). the yield of glucoamylase from type ii cultur ... | 1975 | 1147611 |
| mycotoxin-producing potential of mold flora of dried beans. | to evaluate the potential for mycotoxin production by molds in dried beans, the mold flora of 114 samples was determined both before and after surface disinfection of the beans with 5% naocl. surface disinfection substantially reduced mold incidence, indicating that contamination was mainly on the surface. the flora, both before and after disinfection, was dominated by species of the aspergillus glaucus group, the toxicogenic species a ochracues, penicillium cyclopium, and p. viridicatum, and sp ... | 1975 | 1168442 |