Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| a case of chronic active epstein-barr virus infection mimicking adult-onset still's disease. | an 83-year-old man was diagnosed with adult-onset still's disease (aosd) based on clinical and laboratory findings. however, glucocorticoid had little effect. epstein-barr virus (ebv)-dna was detected in peripheral blood, and autopsy findings confirmed a diagnosis of chronic active ebv infection (caebv). caebv mimics aosd, and the presence of articular involvement and leukocytosis does not exclude the possibility of caebv. caebv should be included in the differential diagnosis of aosd, and measu ... | 2013 | 22370999 |
| a case of blastic plasmacytoid dendritic cell neoplasm: cytomorphological findings of the touch imprint specimen of lymph node. | the patient is a 75-year-old man with axillary lymphadenopathy presenting an indurated papule on his buttock. touch imprint cytology of the biopsied axillary lymph node revealed the monotonous appearance of medium-sized tumor cells. the nuclei had a slightly irregular contour, finely dispersed chromatin, and a conspicuous nucleolus. some tumor cells had intracytoplasmic microvacuoles. immunohistochemistry of the imprint specimens showed that the tumor cells were positive for cd56 and cd123. hist ... | 2013 | 22241735 |
| a case of infantile systemic lupus erythematosus with severe lupus nephritis and ebv infection. | infantile systemic lupus erythematosus (isle) is extremely rare. patients with isle usually become severely unwell and have poor prognosis. epstein-barr virus (ebv) infection has been implicated in the development of sle in both adults and children. recently, we experienced a case of isle with severe lupus nephritis (ln) and ebv infection. a 14-month-old japanese boy was diagnosed with isle according to the american rheumatism association criteria. renal biopsy showed ln classified as internatio ... | 2013 | 28509290 |
| correction: epstein barr virus and helicobacter pylori co-infection are positively associated with severe gastritis in pediatric patients. | [this corrects the article doi: 10.1371/journal.pone.0062850.]. | 2013 | 29294470 |
| cellular immune therapy for viral infections in transplant patients. | stem cell and organ transplantation are considered as the major advances of modern medicine. unfortunately the success of transplantation is limited by its toxicity and infectious complications as a result of profound immunosuppression. viral infections are an extremely common and predictable problem in these patients. antiviral drugs given either prophylactically or as early therapy for patients with detectable viral loads appear to be an effective strategy for reducing viral infections. howeve ... | 2013 | 24434332 |
| isolated primary lymphomatoid granulomatosis of central nervous system. | lymphomatoid granulomatosis (lg) is an infrequent extranodal epstein-barr virus (ebv)-associated b-cell lymphoproliferative disorder characterized by angiocentric and angiodestructive polymorphic lymphoid infiltration. cns is involved in one of every 4 patients, but isolated cns involvement at presentation is rare. a 67-year-old man was admitted to our hospital because of visual impairment. magnetic resonance imaging (mri) revealed a suprasellar mass lesion isointense to gray matter on t1 and t2 ... | 2013 | 24426332 |
| successful treatment with rituximab for angioimmunoblastic t-cell lymphoma. | we experienced a patient with angioimmunoblastic t-cell lymphoma (aitl) without epstein-barr virus-positive b (ebv-b) cells at initial presentation who progressed to aitl with expansion of ebv-b cells at relapse. based on the results of repeated biopsy, the patient was successfully treated with rituximab in combination with chemotherapy at relapse. a repeat biopsy may be necessary to determine the optimum therapeutic strategy at relapse, particularly for patients with suspected expansion of b ce ... | 2013 | 24371775 |
| partial least squares based gene expression analysis in ebv- positive and ebv-negative posttransplant lymphoproliferative disorders. | post-transplant lymphoproliferative disorder (ptld) is a common complication of therapeutic immunosuppression after organ transplantation. gene expression profile facilitates the identification of biological difference between epstein-barr virus (ebv) positive and negative ptlds. previous studies mainly implemented variance/regression analysis without considering unaccounted array specific factors. the aim of this study is to investigate the gene expression difference between ebv positive and ne ... | 2013 | 24377530 |
| reactive oxygen species mediate epstein-barr virus reactivation by n-methyl-n'-nitro-n-nitrosoguanidine. | n-nitroso compounds (nocs) and epstein-barr virus (ebv) reactivation have been suggested to play a role in the development of nasopharyngeal carcinoma (npc). although chemicals have been shown to be a risk factor contributing to the carcinogenesis of npc, the underlying mechanism is not fully understood. we demonstrated recently that n-methyl-n'-nitro-n-nitrosoguanidine (mnng) enhances the genomic instability and tumorigenicity of npc cells via induction of ebv reactivation. however, the mechani ... | 2013 | 24376853 |
| the levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children. | infectious mononucleosis (im) is the clinical presentation of primary infection with epstein-barr virus. although the literature contains a massive amount of information on im, most of this is related specifically to only children or adults separately. in order to distinguish any differences between preschool children and youth patients, we retrospectively analyzed their demographic and clinical features. | 2013 | 24459643 |
| proteomic characterization of murid herpesvirus 4 extracellular virions. | gammaherpesvirinae, such as the human epstein-barr virus (ebv) and the kaposi's sarcoma associated herpesvirus (kshv) are highly prevalent pathogens that have been associated with several neoplastic diseases. as ebv and kshv are host-range specific and replicate poorly in vitro, animal counterparts such as murid herpesvirus-4 (muhv-4) have been widely used as models. in this study, we used muhv-4 in order to improve the knowledge about proteins that compose gammaherpesviruses virions. to this en ... | 2013 | 24386290 |
| ebi2 is a negative regulator of type i interferons in plasmacytoid and myeloid dendritic cells. | epstein-barr virus induced receptor 2 (ebi2), a gαi-coupled g protein-coupled receptor, is a chemotactic receptor for b, t and dendritic cells (dc). genetic studies have also implicated ebi2 as a regulator of an interferon regulatory factor 7 (irf7)-driven inflammatory network (idin) associated with autoimmune diseases, although the corollary in primary type i ifn-producing cells has not been reported. here we demonstrate that ebi2 negatively regulates type i ifn responses in plasmacytoid dc (pd ... | 2013 | 24386204 |
| late onset epstein barr virus seropositive posttransplant lymphoproliferative disorder in two renal transplant receivers. | posttransplant malignancy is one of the most important complications of organ transplantation. immunosuppressive drugs, viral infections such as human herpes virus 8 or epstein-barr virus, exposure to carcinogenic factors such as sun, and host factors can be etiologic factors in the development of malignant disease. in this paper we report 2 cases of late posttransplant lymphoproliferative disorder with malign behavior. | 2013 | 24385813 |
| central nervous system involvement of epstein barr virus associated lymphoproliferative disorder in a child with acute lymphoblastic leukemia: successful treatment with rituximab and interferon-alpha. | central nervous system (cns) involvement of epstein-barr virus (ebv)-associated lymphoproliferative disease is a rare and serious complication in children with leukemia. although rituximab therapy seems to be promising in these cases, persistent hypogammaglobulinemia may appear after treatment due to complete depletion of normal b lymphocytes in the peripheral blood. here we report isolated cns involvement of ebv-associated lymphoproliferative disorder in a 4-year-old boy with acute leukemia. th ... | 2013 | 24385755 |
| post liver transplantation lymphoproliferative disorder mimics recurrence of hepatocellular carcinoma. | we report a case of epstein-barr virus (ebv)-related postliver transplantation lymphoproliferative disorder (ptld) in a patient with post liver transplant which initially presented in a ct scan image mimicking recurrence of hepatocellular carcinoma. histopathology showed atypical plasma cell-like infiltration, and immunohistochemistry confirmed diagnosis of ebv-associated diffuse large b-cell lymphoma. typical imaging from dynamic phases contrast ct scan might not accurately diagnose recurrent h ... | 2013 | 24351512 |
| activated ddr1 increases rs cell survival. | in this issue of blood, cader et al show that tumor microenvironment promotes epstein-barr virus (ebv)-driven lymphomagenesis in hodgkin lymphoma by a novel pathway involving latent membrane protein 1 (lmp1) and discoidin domain receptor 1 (ddr1), which is activated by collagen(s) and contributes to the survival of reed-sternberg (rs) cells. | 2013 | 24357706 |
| [factors involved in host-pathogen interaction for the risk of hodgkin lymphoma induced by epstein barr virus]. | hodgkin lymphoma (hl) is a neoplasm characterized by malignant cells called reed sternberg and hodgkin's cells in the lymphatic system. such cells comprise 1% of the tumor while the remainder is made up of lymphocytes, histiocytes, eosinophils and plasma non-neoplastic cells. the annual global incidence of hl is 3-10/100,000 inhabitants and is most commonly found in young adults. the mechanism by which cell transformation is accomplished is not entirely clear; however, some evidences suggest tha ... | 2013 | 24354244 |
| a meta-analysis on the ebv dna and vca-iga in diagnosis of nasopharyngeal carcinoma. | we conducted a meta-analysis to compare the ebv dna and vca-iga in diagnosis of nasopharyngeal carcinoma, and provide important evidence for screening method of npc. | 2013 | 24353651 |
| human natural killer cells prevent infectious mononucleosis features by targeting lytic epstein-barr virus infection. | primary infection with the human oncogenic epstein-barr virus (ebv) can result in infectious mononucleosis (im), a self-limiting disease caused by massive lymphocyte expansion that predisposes for the development of distinct ebv-associated lymphomas. why some individuals experience this symptomatic primary ebv infection, whereas the majority acquires the virus asymptomatically, remains unclear. using a mouse model with reconstituted human immune system components, we show that depletion of human ... | 2013 | 24360958 |
| [ex vivo inducing cultured epstein-barr virus specific cytotoxic t lymphocytes and evaluation of their killing effect]. | this study was aimed to explore the method for induction and expansion of eb virus specific cytotoxic t lymphocytes (ebv-ctl) in vitro, and to detect their killing effect. peripheral blood mononuclear cells (pbmnc) were collected from 6 ebv seropositive healthy donors, and ebv-transformed b lymphoblastoid cells (blcl)were used as the antigen-presenting cells and antigen stimulant which was irradiated by 40 gy (60)co irradiator. the autologous pbmnc and irradiated blcl were cultured to induce and ... | 2013 | 24370055 |
| human leukocyte antigens and epstein-barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers. | nasopharyngeal carcinoma (npc) is an epstein-barr virus (ebv) associated tumor. in addition to ebv, host genetic factors are believed to be important determinants of npc risk. of all genes studies to date, human leukocyte antigen (hla) genes have shown the most consistent evidence for association with npc, both from candidate-gene studies and genome-wide association studies (gwas). in this report we summarize results from recent studies that evaluated the association between hla and npc, and dis ... | 2013 | 24367763 |
| ebv infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis. | an amplifying role for oral epithelial cells (ecs) in epstein-barr virus (ebv) infection has been postulated to explain oral viral shedding. however, while lytic or latent ebv infections of oro/nasopharyngeal ecs are commonly detected under pathological conditions, detection of ebv-infected ecs in healthy conditions is very rare. in this study, a simple non-surgical tissue sampling procedure was used to investigate ebv infection in the periodontal epithelium that surrounds and attaches teeth to ... | 2013 | 24367478 |
| αvβ6- and αvβ8-integrins serve as interchangeable receptors for hsv gh/gl to promote endocytosis and activation of membrane fusion. | herpes simplex virus (hsv)--and herpesviruses in general--encode for a multipartite entry/fusion apparatus. in hsv it consists of the hsv-specific glycoprotein d (gd), and three additional glycoproteins, gh/gl and gb, conserved across the herpesviridae family and responsible for the execution of fusion. according to the current model, upon receptor binding, gd propagates the activation to gh/gl and to gb in a cascade fashion. questions remain about how the cascade of activation is controlled and ... | 2013 | 24367260 |
| [immunologic indexes, enzyme status of lymphocytes and functional activity of blood neutrophils in children with infectious mononucleosis caused by epstein-barr virus]. | explore the immunological parameters, levels of activity of nad(p)-dependent dehydrogenases lymphocytes, interferon status parameters, phagocytic activity and chemiluminescence response of neutrophils in the blood of children in the acute phase of infectious mononucleosis caused by the epstein-barr virus. | 2013 | 24340961 |
| not another case of mono: epstein-barr virus (ebv) associate hemophagocytic lymphohistiocytosis (hlh). | male, 30 final diagnosis: hemophagocytic lymphohistiocytosis (lhl) symptoms: abdominal pain • fever • hypotension • pancytopenia | 2013 | 24340129 |
| upregulation of endocan by epstein-barr virus latent membrane protein 1 and its clinical significance in nasopharyngeal carcinoma. | endocan (or called esm-1) has been shown to have tumorigenic activities and its expression is associated with poor prognosis in various cancers. latent membrane protein 1 (lmp1) is an epstein-barr virus (ebv)-encoded oncoprotein and has been shown to play an important role in the pathogenesis of ebv-associated nasopharyngeal carcinoma (npc). to further understand the role of lmp1 in the pathogenesis of npc, microarray analysis of lmp1-regulated genes in epithelial cells was performed. we found t ... | 2013 | 24340011 |
| epstein-barr viral productive amplification reprograms nuclear architecture, dna replication, and histone deposition. | the spontaneous transition of epstein-barr virus (ebv) from latency to productive infection is infrequent, making its analysis in the resulting mixed cell populations difficult. we engineered cells to support this transition efficiently and developed ebv dna variants that could be visualized and measured as fluorescent signals over multiple cell cycles. this approach revealed that ebv's productive replication began synchronously for viral dnas within a cell but asynchronously between cells. ebv ... | 2013 | 24331459 |
| two rare cases of epstein-barr virus-associated lymphoproliferative disorders in inflammatory bowel disease patients on thiopurines and other immunosuppressive medications. | the setting of chronic immunosuppression in inflammatory bowel disease (ibd) may promote the proliferation of epstein-barr virus-positive neoplastic clones. we report two rare cases of epstein-barr virus-associated lymphoproliferative disorder in ibd patients: one resembled lymphomatoid granulomatosis, and the other was a lymphoma resembling hodgkin lymphoma. there are currently no guidelines for the prevention of lymphoproliferative disorder in ibd patients on immunosuppressive therapy. | 2013 | 24330365 |
| rituximab in the treatment of ebv-positive low grade b-cell lymphoma. | following infection of b lymphocytes by epstein barr virus (ebv), the viral genome remains in the nucleus, and a latency phase is established, during which only a small proportion of the viral genes are expressed. among them, lmp1 is essential for transformation. rituximab is a potent agent used in the treatment of low grade b-cell lymphomas and is also widely used for the treatment of post-transplant lymphoproliferative disorders caused by ebv. the effect of rituximab treatment on the latent eb ... | 2013 | 24324119 |
| anti-mitochondrial antibody positive autoimmune hepatitis triggered by ebv infection in a young girl. | autoimmune hepatitis (aih) is rare in children. two types of childhood autoimmune hepatitis are recognized: aih type 1 which is characterized by the presence of smooth muscle (sma) and/or antinuclear (ana) antibodies; and aih type 2 which is positive for anti-liver kidney microsomal type 1 (anti-lkm-1) antibody. anti-mitochondrial antibody (ama) is considered the hallmark for primary biliary cirrhosis (pbc) that occurs primarily in adult women and is characterized by destruction of the intralobu ... | 2013 | 24206743 |
| acute pancreatitis as atypical manifestation of epstein-barr virus infection. | 2013 | 24206559 | |
| persistence of ebv antigen-specific cd8 t cell clonotypes during homeostatic immune reconstitution in cancer patients. | persistent viruses are kept in check by specific lymphocytes. the clonal t cell receptor (tcr) repertoire against epstein-barr virus (ebv), once established following primary infection, exhibits a robust stability over time. however, the determinants contributing to this long-term persistence are still poorly characterized. taking advantage of an in vivo clinical setting where lymphocyte homeostasis was transiently perturbed, we studied ebv antigen-specific cd8 t cells before and after non-myelo ... | 2013 | 24205294 |
| immunologic difference between hypersensitivity to mosquito bite and hemophagocytic lymphohistiocytosis associated with epstein-barr virus infection. | hemophagocytic lymphohistiocytosis (hlh) is a life-threatening, virus-triggered immune disease. hypersensitivity to mosquito bite (hmb), a presentation of chronic active epstein-barr virus infection (caebv), may progress to hlh. this study aimed to investigate the immunologic difference between the hmb episodes and the hlh episodes associated with ebv infection. immunologic changes of immunoglobulins, lymphocyte subsets, cytotoxicity, intracellular perforin and granzyme expressions, ebv virus lo ... | 2013 | 24204658 |
| epstein-barr virus_encoded lmp1 upregulates microrna-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced apoptosis by suppressing pdcd4 and fas-l. | approximately 30% of patients with epstein-barr virus (ebv)-positive advanced nasopharyngeal carcinoma (npc) display chemoresistance to cisplatin-based regimens, but the underlying mechanisms are unclear. the epstein-barr virus (ebv)-encoded latent membrane protein 1 (lmp1), a functional homologue of the tumor necrosis factor receptor family, contributes substantially to the oncogenic potential of ebv through the activation of multiple signaling pathways, and it is closely associated with a poor ... | 2013 | 24194922 |
| [sulfasalazine-induced dress syndrome associated with epstein barr virus reactivation]. | 2013 | 24225043 | |
| epstein-barr virus is a necessary causative agent in the pathogenesis of multiple sclerosis: commentary. | 2013 | 24218488 | |
| epstein-barr virus is a necessary causative agent in the pathogenesis of multiple sclerosis: no. | 2013 | 24218487 | |
| epstein-barr virus is a necessary causative agent in the pathogenesis of multiple sclerosis: yes. | 2013 | 24218486 | |
| an adult case of systemic epstein-barr virus-positive t/natural killer-cell lymphoproliferative disorder with good outcome. | epstein-barr virus-positive t/natural killer (nk)-cell lymphoproliferative disorder (ebv+t/nk lpd) encompasses a heterogeneous group of disorders that have a common feature with excessive lymphoid proliferation of mainly t cells and/or nk cells. this disease is rare, predominantly affects children and young adults, and associated with high mortality. herein, we report a case of ebv+t/nk lpd that occurred in an old woman with good outcome. the patient presented with fever, splenomegaly, and pancy ... | 2013 | 24228130 |
| activation of msrv-type endogenous retroviruses during infectious mononucleosis and epstein-barr virus latency: the missing link with multiple sclerosis? | the etiology of multiple sclerosis (ms) is still unclear. the immuno-pathogenic phenomena leading to neurodegeneration are thought to be triggered by environmental (viral?) factors operating on predisposing genetic backgrounds. among the proposed co-factors are the epstein barr virus (ebv), and the potentially neuropathogenic herv-w/msrv/syncytin-1 endogenous retroviruses. the ascertained links between ebv and ms are history of late primary infection, possibly leading to infectious mononucleosis ... | 2013 | 24236019 |
| defining the expression hierarchy of latent t-cell epitopes in epstein-barr virus infection with tcr-like antibodies. | epstein-barr virus (ebv) is a gamma herpesvirus that causes a life-long latent infection in human hosts. the latent gene products lmp1, lmp2a and ebna1 are expressed by ebv-associated tumors and peptide epitopes derived from these can be targeted by cd8 cytotoxic t-lymphocyte (ctl) lines. whilst ctl-based methodologies can be utilized to infer the presence of specific latent epitopes, they do not allow a direct visualization or quantitation of these epitopes. here, we describe the characterizati ... | 2013 | 24240815 |
| reversible bilateral basal ganglia lesions related to epstein-barr virus encephalitis. | 2013 | 24239413 | |
| high grade transformation in a case of adenoid cystic carcinoma associated with epstein-barr virus expression. | 2013 | 24247629 | |
| current treatment options for local residual nasopharyngeal carcinoma. | local residual disease occurs in 7-13 % after primary treatment for nasopharyngeal carcinoma (npc). to prevent tumor progression and/or distant metastasis, treatment is indicated. biopsy is the "gold standard" for diagnosing residual disease. because late histological regression frequently is seen after primary treatment for npc, biopsy should be performed when imaging or endoscopy is suspicious at 10 weeks. different modalities can be used in the treatment of local residual disease. interesting ... | 2013 | 24243165 |
| molecular properties of the epstein-barr virus bfrf3 gene. | 2013 | 24242362 | |
| studying epstein-barr virus pathologies and immune surveillance by reconstructing ebv infection in mice. | epstein-barr virus (ebv) is a γ herpes virus endemic in humans and transforming human b lymphocytes. it causes a variety of human pathologies ranging from infectious mononucleosis upon acute infection to ebv-driven b-cell lymphomas. in humans, ebv-infected cells are under powerful immune surveillance by t and nk cells. if this immune surveillance is compromised as in immunosuppressed (aids- or posttransplantation) patients, the virus can spread from rare, ebv-containing cells and cause life-thre ... | 2013 | 24241423 |
| human papillomavirus and epstein-barr virus co-infection in cervical carcinoma in algerian women. | despite the fact that the implication of human papillomavirus (hpv) in the carcinogenesis and prognosis of cervical cancer is well established, the impact of a co-infection with high risk hpv (hr-hpv) and epstein-barr virus (ebv) is still not fully understood. | 2013 | 24252325 |
| identification and characterization of ebv genomes in spontaneously immortalized human peripheral blood b lymphocytes by ngs technology. | we conducted genomic sequencing to identify epstein barr virus (ebv) genomes in 2 human peripheral blood b lymphocytes that underwent spontaneous immortalization promoted by mycoplasma infections in culture, using the high-throughput sequencing (hts) illumina miseq platform. the purpose of this study was to examine if rapid detection and characterization of a viral agent could be effectively achieved by hts using a platform that has become readily available in general biology laboratories. | 2013 | 24252203 |
| combination of arsenic and interferon-α inhibits expression of kshv latent transcripts and synergistically improves survival of mice with primary effusion lymphomas. | kaposi sarcoma-associated herpesvirus (kshv) is the etiologic agent of primary effusion lymphomas (pel). pel cell lines infected with kshv, but negative for epstein-barr virus have a tumorigenic potential in non-obese diabetic/severe combined immunodeficient mice and result in efficient engraftment and formation of malignant ascites with notable abdominal distension, consistent with the clinical manifestations of pel in humans. | 2013 | 24250827 |
| immunohistochemical expression of latent membrane protein 1 (lmp1) and p53 in nasopharyngeal carcinoma: moroccan experience. | nasopharyngeal carcinoma (npc) is a malignant epithelial tumor intimately associated with epstein-barr virus (ebv). npc is a characteristic tumor displaying epidemiological, genetic and regional distribution properties that makes it unique by its natural behavior. | 2013 | 24250311 |
| rapid generation of ebv-specific cytotoxic t lymphocytes resistant to calcineurin inhibitors for adoptive immunotherapy. | epstein-barr virus (ebv)-associated posttransplant lymphoproliferative disorder (ptld) remains a major cause of morbidity and mortality after hematopoietic stem cell (hsct) or solid organ transplant (sot). strategies to reconstitute immunity by adoptive transfer of ebv-specific cytotoxic t lymphocyte (ctl) therapy while highly effective in the hsct setting where immunosuppression can be withdrawn have been less successful in the sot setting where continued immunosuppression therapy is necessary. ... | 2013 | 24266973 |
| [infectious mononucleosis--a "childhood disease" of great medical concern]. | infectious mononucleosis is usually a benign self-limiting disease, which is caused by the epstein-barr virus (ebv), a member of the herpes virus family. ebv virions have a double-stranded, linear dna genome surrounded by a protein capsid. ebv is transmitted primarily through saliva, but transmission via blood and droplets also occurs. infectious mononucleosis is the most frequent clinical manifestation of ebv infection and occurs during primary infection with the virus. with some exceptions, on ... | 2013 | 24266247 |
| cd56 positive diffuse large b-cell lymphoma: a case report and literature review. | cd56 positive b-cell lymphoma is very rare. we experienced a case of cd56 positive diffuse large b-cell lymphoma, occurred in a young child. a 5-year-old girl complained with snoring and open mouth breathing. no any abnormality in laboratory or physical examination was present, except enlarged both tonsils. bilateral tonsillectomy was performed. cut sections of right tonsil showed a 2 cm size, solid mass. on microscopically, large monomorphic lymphoid cells were diffusely proliferated and showed ... | 2013 | 24294395 |
| post cardiac transplantation t-cell lymphoproliferative disorder presenting as a solitary lung nodule. | post-transplantation lymphoproliferative disorder (ptld) is an infrequent, but serious complication of solid organ and bone marrow transplantations. the vast majority of the cases are of b-cell origin and usually associated with epstein-barr virus (ebv) infection. the non-b (t and nk cell) ptlds account for up to 14% of the ptld cases in western countries. we report a case of a 66-year-old man who received an orthotopic heart transplant for cardiomyopathy 7 years prior to presentation. he was re ... | 2013 | 24294392 |
| epstein-barr virus infection correlates with the expression of cox-2, p16(ink4a) and p53 in classic hodgkin lymphoma. | classic hodgkin lymphoma (chl), a germinal-center related b cell neoplasm in almost all cases, is characterized by scarcity of the neoplastic hodgkin/reed-sternberg (h/rs) cells. epstein-barr virus (ebv) has been shown to affect cell cycle and regulation of apoptosis. in total, 95 cases of chl were studied. five-micrometer sections were prepared and stained with hematoxylin and eosin and immunohistochemical streptavidin-biotin methods for ebv-lmp-1, cox-2, p53, p16, ki-67 and cleaved caspase-3. ... | 2013 | 24294363 |
| cancer in hiv patients. | starting antiretroviral therapy (art) with low cd4 counts raises the likelihood of certain cancers, but others increase with longer time on therapy, reflecting the rising risk associated with older age. researchers in the usa looked at patterns of cancer incidence and timing after art initiation (yanik, et al. clin infect dis. 2013;57:756-64). the analysis included medical records from 11,485 participants in eight u.s. hiv clinical cohorts who started art between 1996 and 2011. around 80% were m ... | 2013 | 24322384 |
| [composite lymphoma consisting of adult t-cell leukemia-lymphoma and diffuse large b-cell lymphoma]. | a 68-year-old man was admitted to our hospital because of left back pain and systemic lymphadenopathy with hypercalcemia. serum anti-htlv-1 antibody was positive. left cervical lymph node (ln) biopsy revealed proliferation of medium-sized to large cd4-positive atypical cells with modest infiltration of cd20 and epstein-barr virus (ebv)-encoded rna dual-positive atypical large cells. monoclonal integration of htlv-1 proviral dna, plus clonal rearrangement of the t-cell receptor chain gene and the ... | 2013 | 24305540 |
| environmental factors in multiple sclerosis. | although genetic susceptibility explains the clustering of multiple sclerosis (ms) cases within families, the changes in ms risk that occur with migration can be explained only by changes in the environment. the strongest known risk factor for ms is infection with epstein-barr virus (ebv). compared with uninfected individuals, the hazard of developing ms is approximately 15-fold higher among individuals infected with ebv in childhood and about 30-fold higher among those infected with ebv in adol ... | 2013 | 24289836 |
| lupeol is one of active components in the extract of chrysanthemum indicum linne that inhibits lmp1-induced nf-κb activation. | we have previously reported that seventy percent ethanol extract of chrysanthemum indicum linne (cie) strongly reduces epstein-barr virus (ebv)-transformed lymphoblastoid cell line (lcl) survival by inhibiting virus-encoded latent infection membrane protein 1 (lmp1)-induced nf-κb activation. to identify an active compound(s) in cie that inhibits lmp1-induced nf-κb activation, activity-guided fractionation was employed. the ch2cl2 fraction of cie strongly reduced lmp1-induced nf-κb activation and ... | 2013 | 24303085 |
| no increase in epstein-barr virus viral load in a group of 30 asymptomatic patients with crohn's disease. | 2013 | 24300873 | |
| high seroprevalence of human herpesvirus 8 infection in patients with systemic lupus erythematosus. | systemic lupus erythematosus (sle) is an autoimmune disease that is associated with genetic and environmental factors and microbial infection. with respect to microbial infection, the epstein-barr virus (ebv) has been a widely discussed issue in recent decades. human herpesvirus 8 (hhv-8) belongs to the same γ-herpesvirus subfamily as ebv and is closely related to it. until now, only one paper has reported the prevalence of hhv-8 infection in sle patients. the goal of this study was to detect th ... | 2013 | 24283670 |
| acute cytomegalovirus hepatitis in an immunocompetent host. | a 52-year-old woman presented with a 1-week history of recurrent fevers and joint pains accompanied by abdominal and low back discomfort. she has a history of hypoparathyroidism and is on calcium supplements. physical examination revealed fever and tachycardia. the rest of the examination was normal. laboratory tests showed newly increased transaminase activity. serum bilirubin and prothrombin time were normal. she was admitted for evaluation of acute hepatitis. serology for hepatitis a, b, c an ... | 2013 | 24275336 |
| tcrγ rearrangement and epstein- barr virus are detected both in lymphadenopathy of adult-onset still's disease and in accompanying peripheral t-cell lymphoma. | 2013 | 24274721 | |
| il-35: a potential target for the treatment of atherosclerosis. | the imbalance of anti- inflammatory/pro-inflammatory cytokines plays an important role in the process of atherosclerosis. il-35 is an anti-inflammatory cytokine comprising the p35 subunit of il-12 and the subunit epstein-barr virus (ebv) -induced gene 3(ebi3). accumulating evidence showed that il-35 up-regulates the expression of anti-inflammatory cytokines, induces the generation of cd4 + regulatory t cells, inhibits cd4 + effector t cells response and other target cells activity, and reduces t ... | 2013 | 24273881 |
| the alice in wonderland syndrome. | the alice in wonderland syndrome is a term applied to altered bizarre perceptions of size and shapes of a patient's body and illusions of changes in the forms, dimensions, and motions of objects that a patient with this syndrome encounters. these metamorphopsias arise during complex partial seizures, migraine headaches, infections, and intoxications. the illusions and hallucinations resemble the strange phenomena that alice experienced in lewis carroll's alice's adventures in wonderland. charles ... | 2013 | 24290480 |
| epstein-barr virus associated primary intracranial smooth muscle tumor in hiv positive patient: case report and review of the literature. | the authors report a case of hiv-positive patient with primary intracranial smooth muscle tumor evidence of epstein-barr virus (eb v) infection in this tumor is proven by in situ hybridization for ebv-encoded rna (eber). review of the literature shows that the occurring of smooth muscle tumor at intracranial site is extremely rare and most cases are hiv-infected patient. it also shows an association with ebv infection. | 2013 | 24319862 |
| epstein-barr virus in cutaneous pathology. | epstein-barr virus (ebv) is a ubiquitous double-stranded dna gamma herpes virus and it is present in 95% of adults. ebv infection is seen in many oncological conditions, although there is controversy regarding whether ebv is causative, a cofactor, or just a coincidental infection. some of these conditions involve the skin as the main or as a secondary organ. in this report, we review several tumoral and nontumoral cutaneous conditions, which are related to ebv infection, and describe the epidemi ... | 2013 | 24257189 |
| abducens nerve palsy in a patient with scrub typhus: a case report. | abducens nerve palsy is a known but rare complication of a few bacterial and viral infections like mycoplasma pneumonia, cytomegalovirus, epstein-barr virus, hanta virus, herpes zoster, and measles. abducens nerve palsy due to scrub typhus is extremely rare and so far only one case has been reported in the literature. scrub typhus is a febrile illness caused by rickettsia, orientia tsutsugamushi, a gram negative intracellular obligate parasite which is endemic in asia. this disease can present w ... | 2013 | 24522141 |
| poor periodontal health: a cancer risk? | evidence indicates that chronic infections and inflammation are associated with increased risk of cancer development. there has also been considerable evidence that proves the interrelationship between bacterial and viral infections and carcinogenesis. periodontitis is a chronic oral infection thought to be caused by gram-negative anaerobic bacteria in the dental biofilm. periodontal bacteria and viruses may act synergistically to cause periodontitis. many studies have shown that periodontal poc ... | 2013 | 24554877 |
| lymphomatoid granulomatosis: a practical review for pathologists dealing with this rare pulmonary lymphoproliferative process. | lymphomatoid granulomatosis (lyg) is a rare b-cell lymphoproliferative disorder predominantly involving the lungs, but poorly-recognized among clinicians and pathologists. it is an epstein-barr virus (ebv)-driven disease mimicking several other diseases on clinical and radiological grounds, generally showing multiple, bilateral nodular, ill-defined infiltrates of the lungs tending to coalescence and/or cavitation. lyg often affects middle-aged males with an underlying immunodeficiency and common ... | 2013 | 24466760 |
| epstein-barr virus-induced hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is one of the complications of epstein-barr virus (ebv) infection. although the patients who have developed hlh following ebv have normal immune system, there are a few patients with ebv-induced immune deficiency who develop hlh as well. here, we describe the case of a 10-year-old girl with neurological complications caused by ebv-induced hlh. the patient received rituximab, leading to weakening inflammation associated with ebv infection and suppression o ... | 2013 | 24505517 |
| plasma cell neoplasms presenting with masses: a study on morphology, expression of cd56 and cyclin d1, and presence of epstein-barr virus in 39 thai patients in siriraj hospital. | plasma cell neoplasms (pcns) presenting with masses are not common. variable morphology, expression of cd56 and cyclin d1, and epstein-barr virus (ebv)-encoded small rna (eber) status have been described with a promising diagnostic role. there is no data of these findings in thai patients. | 2013 | 24511724 |
| hemophagocytic lymphohistiocytosis caused by primary epstein-barr virus in patient with crohn's disease. | we present a case of a 19-year-old man with a 6-year history of crohn's disease (cd), previously treated with 6-mercaptopurine, who was admitted to our department for epstein-barr virus (ebv) infection and subsequently developed a hemophagocytic lymphohistiocytosis (hlh). hlh is a rare disease which causes phagocytosis of all bone marrow derived cells. it can be a primary form as a autosomic recessive disease, or a secondary form associated with a variety of infections; ebv is the most common, t ... | 2013 | 24520429 |
| a novel mouse xenotransplantation model of ebv-t/nk-lpd and the application of the mouse model. | chronic active epstein-barr virus (ebv) infection (caebv), characterized by proliferation of ebv-infected t or nk cells, is a disease of unknown pathogenesis and requires hematopoietic stem cell transplantation for curative treatment. here we show that intravenous injection of peripheral blood mononuclear cells (pbmcs) isolated from patients with caebv to nod/shi-scid/il-2r γ(null) (nog) mice leads to engraftment of ebv-infected t or nk cells. analysis of tcr repertoire identified an identical p ... | 2013 | 24390103 |
| [allogenic hematopoietic stem cell transplantation with unrelated cord blood: report of three cases from the chilean cord blood bank]. | public cord blood banks are a source of hematopoietic stem cells for patients with hematological diseases who lack a family donor and need allogeneic transplantation. in june 2007 we started a cord blood bank with units donated in three maternity wards in santiago, chile. we report the first three transplants done with cord blood units form this bank. cord blood units were obtained by intrauterine collection at delivery. they were depleted of plasma and red cells and frozen in liquid nitrogen. t ... | 2013 | 24448864 |
| epstein-barr virus encoded lmp1 regulates cyclin d1 promoter activity by nuclear egfr and stat3 in cne1 cells. | the principal epstein-barr virus (ebv) oncoprotein, latent membrane protein 1 (lmp1) is strongly associated with nasopharyngeal carcinoma (npc), a prevalent cancer in china. the epidermal growth factor receptor (egfr) is important in carcinogenesis, as it is a ubiquitously expressed receptor tyrosine kinase. signal transducer and activator of transcription 3 (stat3) is a master transcriptional regulator in proliferation and apoptosis. our previous study demonstrated that the nuclear egfr could b ... | 2013 | 24499623 |
| [report of a case with secondary acute promyelocytic leukemia after therapy for hemophagocytic lymphohistiocytosis and review of literature]. | to explore the characteristics and risk of etoposide-related leukemia in the treatment of hemophagocytic lymphohistiocytosis (hlh). | 2013 | 24495767 |
| low-molecular-mass secretome profiling identifies c-c motif chemokine 5 as a potential plasma biomarker and therapeutic target for nasopharyngeal carcinoma. | cancer cell secretome profiling has been shown to be a promising strategy for identifying potential body fluid-accessible cancer biomarkers and therapeutic targets. however, very few reports have investigated low-molecular-mass (lmr) proteins (<15kda) in the cancer cell secretome. in the present study, we applied tricine-sds-gel-assisted fractionation in conjunction with lc-ms/ms to systemically identify lmr proteins in the secretomes of three nasopharyngeal carcinoma (npc) cell lines. we examin ... | 2013 | 24080422 |
| burkitt lymphoma: beyond discoveries. | first described in 1958 in uganda, burkitt lymphoma (bl) attracted interest worldwide following reports of its uneven geographic distribution and rapidly fatal clinical course. both suggested infectious etiology and curability. seminal discoveries followed in quick succession. viral etiology - due to epstein-barr virus (ebv) - was confirmed. chromosomal translocations, involving cellular myc, a protooncogene, were discovered, shown to be a hallmark of bl, and central to the genetic basis of canc ... | 2013 | 24079372 |
| high molecular weight complex analysis of epstein-barr virus latent membrane protein 1 (lmp-1): structural insights into lmp-1's homo-oligomerization and lipid raft association. | lmp-1 is a constitutively active tumor necrosis factor receptor analog encoded by epstein-barr virus. lmp-1 activation correlates with oligomerization and raft localization, but direct evidence of lmp-1 oligomers is limited. we report that lmp-1 forms multiple high molecular weight native lmp-1 complexes when analyzed by bn-page, the largest of which are enriched in detergent resistant membranes. the largest of these high molecular weight complexes are not formed by purified lmp-1 or by loss of ... | 2013 | 24075898 |
| liver in haematological disorders. | prothrombotic haematological disorders, in particular myeloproliferative disorders, are identified in a significant proportion of patients with budd-chiari syndrome and portal vein thrombosis (pvt). multiple prothrombotic disorders may coexist. pvt is diagnosed in one fourth of patients with cirrhosis and is more common with advanced liver disease and hepatocellular carcinoma. pvt in cirrhosis can precipitate decompensation. intrahepatic microthrombosis may play a role in the pathogenesis of hep ... | 2013 | 24090939 |
| fulminant epstein barr virus encephalitis - can it be due to x linked lymphoproliferative disease. | 2013 | 24096853 | |
| long-term exposure to belatacept in recipients of extended criteria donor kidneys. | patients in the benefit-ext study received extended criteria donor kidneys and a more intensive (mi) or less intensive (li) belatacept immunosuppression regimen, or cyclosporine a (csa). patients who remained on assigned therapy through year 3 were eligible to enter a long-term extension (lte) study. three hundred four patients entered the lte (n = 104 mi; n = 113 li; n = 87 csa), and 260 continued treatment through year 5 (n = 91 mi; n = 100 li; n = 69 csa). twenty patients died during the lte ... | 2013 | 24103072 |
| ebna-1 igg titers in sardinian multiple sclerosis patients and controls. | multiple sclerosis (ms) is thought to be triggered by environmental factors acting on a genetic predisposition. sardinians share a homogeneous genetic background and boast one of the highest ms prevalence worldwide. we investigated epstein-barr virus (ebv) antibody prevalence in sardinian population by elisa. our results show a higher serum prevalence of ebna-1 igg in ms patients compared to healthy controls. moreover, analyzing a subset of patients treated for 6 months with ifn-β, we observed a ... | 2013 | 24099984 |
| [lipschütz ulcer: a rare and underdiagnosed cause of genital ulcer]. | 2013 | 24106571 | |
| epstein-barr virus latent membrane protein 2 effects on epithelial acinus development reveal distinct requirements for the py and yeea motifs. | epstein-barr virus (ebv) is a gammaherpesvirus associated with numerous cancers, including the epithelial cancers nasopharyngeal carcinoma (npc) and gastric carcinoma. the latent membrane protein 2 (lmp2) encoded by ebv is consistently detected in npc tumors and promotes a malignant phenotype when expressed in epithelial cells by inducing transformation and migration and inhibiting differentiation. grown in three dimensions (3d) on matrigel, the nontumorigenic mammary epithelial cell line mcf10a ... | 2013 | 24109232 |
| x-linked lymphoproliferative syndromes and related autosomal recessive disorders. | x-linked lymphoproliferative (xlp) syndromes and related autosomal disorders are severe primary immune deficiencies triggered by infection with epstein-barr virus (ebv), the causative agent of infectious mononucleosis. recent findings reviewed herein provided key new insights into the genetic and immunological basis of these diseases. they also improved our comprehension of the immunological mechanisms controlling ebv infection. | 2013 | 24113228 |
| spontaneous lytic replication and epitheliotropism define an epstein-barr virus strain found in carcinomas. | the epstein-barr virus (ebv) is found in a variety of tumors whose incidence greatly varies around the world. a poorly explored hypothesis is that particular ebv strains account for this phenomenon. we report that m81, a virus isolated from a chinese patient with nasopharyngeal carcinoma (npc), shows remarkable similarity to other npc viruses but is divergent from all other known strains. m81 exhibited a reversed tropism relative to common strains with a reduced ability to infect b cells and a h ... | 2013 | 24120866 |
| post-transplant lymphoproliferative disorder after pancreas transplantation: a united network for organ sharing database analysis. | there are not a great deal of data on post-transplant lymphoproliferative disorder (ptld) following pancreas transplantation. we analyzed the united network for organ sharing national database of pancreas transplants to identify predictors of ptld development. a univariate cox model was generated for each potential predictor, and those at least marginally associated (p < 0.15) with ptld were entered into a multivariable cox model. ptld developed in 43 patients (1.0%) of 4205 pancreas transplants ... | 2013 | 24118329 |
| composite diffuse large b-cell lymphoma and classical hodgkin's lymphoma of the stomach: case report and literature review. | the combination of classical hodgkin's lymphoma (chl) and non-hodgkin lymphoma coexisting in the same patient is not common, especially in one extranodal location. here we present a rare case of composite diffuse large b-cell lymphoma (dlbcl) and chl occurring simultaneously in the stomach of a 53-year-old female who presented with upper abdominal discomfort and gas pain. surgery was performed and the disease was diagnosed pathologically as composite lymphoma of dlbcl and chl using hematoxylin-e ... | 2013 | 24115832 |
| a case of plasmablastic lymphoma of the liver without human immunodeficiency virus infection. | plasmablastic lymphoma (pbl) is a very rare b-cell lymphoproliferative disorder was with an aggressive clinical behavior that recently characterized by the world health organization. although pbl is most commonly observed in the oral cavity of human immunodeficiency virus (hiv)-positive patients, it can also be observed at extra-oral sites in hiv-negative patients. epstein-barr virus (ebv) may be closely related the pathogenesis of pbl. pbl shows different clinicopathological characteristics bet ... | 2013 | 24115831 |
| epidemiological features of aplastic anemia in indian children. | to study the socio-demographic profile and clinico-hematological features of aplastic anemia in children presenting at a single institution over 5 y. | 2013 | 24122422 |
| a new cloning and expression system yields and validates tcrs from blood lymphocytes of patients with cancer within 10 days. | antigen-specific t cell therapy, or t cell receptor (tcr) gene therapy, is a promising immunotherapy for infectious diseases and cancers. however, a suitable rapid and direct screening system for antigen-specific tcrs is not available. here, we report an efficient cloning and functional evaluation system to determine the antigen specificity of tcr cdnas derived from single antigen-specific human t cells within 10 d. using this system, we cloned and analyzed 380 epstein-barr virus-specific tcrs f ... | 2013 | 24121927 |
| isolated cerebral post-transplant lymphoproliferative disorder in a lymphoma recipient. | post-transplant lymphoproliferative disorder (ptld) can occur after solid organ transplantation (sot) or hematopoietic stem cell transplantation (hsct). the majority of ptlds are related to the reactivation of epstein-barr virus (ebv) in the lymphoid organs. pltds in hsct recipients tend to present with systemic involvement, and isolated ptld in these patients is rare. only 14 isolated cerebral ptlds have been reported in hsct recipients, and none have been reported in lymphoma patients. when di ... | 2013 | 24126003 |
| a novel hsp90 inhibitor at13387 induces senescence in ebv-positive nasopharyngeal carcinoma cells and suppresses tumor formation. | nasopharyngeal carcinoma (npc) is an epithelial malignancy strongly associated with epstein-barr virus (ebv). at13387 is a novel heat shock protein 90 (hsp90) inhibitor, which inhibits the chaperone function of hsp90 and reduces expression of hsp90-dependent client oncoproteins. this study aimed to evaluate both the in vitro and in vivo antitumor effects of at13387 in the ebv-positive npc cell line c666-1. | 2013 | 24156782 |
| epstein-barr virus-driven lymphomagenesis in the context of human immunodeficiency virus type 1 infection. | epstein-barr virus (ebv) is a ubiquitous human γ-herpes virus which establishes a life-long asymptomatic infection in immunocompetent hosts. in human immunodeficiency virus type 1 (hiv-1) infected patients, the impaired immunosurveillance against ebv may favor the development of ebv-related diseases, ranging from lymphoproliferative disorders to b cell non-hodgkin's lymphomas (nhl). antiretroviral therapy (art) has significantly modified the natural course of hiv-1 infection, resulting in decrea ... | 2013 | 24151490 |
| slippery substrates impair atp-dependent protease function by slowing unfolding. | atp-dependent proteases are responsible for most energy-dependent protein degradation across all species. proteases initially bind an unstructured region on a substrate and then translocate along the polypeptide chain, unfolding and degrading protein domains as they are encountered. although this process is normally processive, resulting in the complete degradation of substrate proteins to small peptides, some substrates are released prematurely. regions of low sequence complexity within the sub ... | 2013 | 24151080 |
| the cycle of ebv infection explains persistence, the sizes of the infected cell populations and which come under ctl regulation. | previous analysis of epstein-barr virus (ebv) persistent infection has involved biological and immunological studies to identify and quantify infected cell populations and the immune response to them. this led to a biological model whereby ebv infects and activates naive b-cells, which then transit through the germinal center to become resting memory b-cells where the virus resides quiescently. occasionally the virus reactivates from these memory cells to produce infectious virions. some of this ... | 2013 | 24146621 |
| crystal structure of the gamma-2 herpesvirus lana dna binding domain identifies charged surface residues which impact viral latency. | latency-associated nuclear antigen (lana) mediates γ2-herpesvirus genome persistence and regulates transcription. we describe the crystal structure of the murine gammaherpesvirus-68 lana c-terminal domain at 2.2 å resolution. the structure reveals an alpha-beta fold that assembles as a dimer, reminiscent of epstein-barr virus ebna1. a predicted dna binding surface is present and opposite this interface is a positive electrostatic patch. targeted dna recognition substitutions eliminated dna bindi ... | 2013 | 24146618 |
| a structural basis for brd2/4-mediated host chromatin interaction and oligomer assembly of kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus lana proteins. | kaposi sarcoma-associated herpesvirus (kshv) establishes a lifelong latent infection and causes several malignancies in humans. murine herpesvirus 68 (mhv-68) is a related γ2-herpesvirus frequently used as a model to study the biology of γ-herpesviruses in vivo. the kshv latency-associated nuclear antigen (klana) and the mhv68 mlana (orf73) protein are required for latent viral replication and persistence. latent episomal kshv genomes and klana form nuclear microdomains, termed 'lana speckles', ... | 2013 | 24146614 |