Publications

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[metastrongylus madagascariensis, a 4th species of pulmonary strongyle infesting the domestic swine]. 195613403457
[comparative quantitative investigations of the allocortex of wild and domestic swine]. 195613468676
[fibrillar architecture of the epidermis and sinus hair of the snout of the domestic pig (sus scrofa domesticus), detected by polarization]. 195514387122
the microscopic anatomy of the digestive tract of sus scrofa domestica. 195413207582
the trypanocidal effects of dimidium bromide (phenanthridinium 1553) on trypanosoma simiae in domestic pigs. 194818891584
[contribution to the study of cartilagines corniculata (santorini) and cuneiformis (wrisbergi) in the larynx of sus scrofa domestica]. 194818104325
the structure and differentiation of the specific cellular elements of the pars intermedia of the hypophysis of the domestic pig.the bearing of these results on the herring-cushing theory of pituitary secretion is apparent. for the first time a true secretion antecedent has been demonstrated in the cells of the pars intermedia, an antecedent which appears in the cells at the same period of development at which active pressor effects may be obtained from the gland extracts. the route of export of this material from the gland to its point of utilization, however, is unknown; it may go by way of the blood or, as required by ...192219868654
intestinal amebiasis in the domestic pig. 191019971978
a comparative study of the biological characters and pathogenesis of bacillus x (sternberg), bacillus icteroides (sanarelli), and the hog-cholera bacillus (salmon and smith).1. bacillus x (sternberg) belongs to the colon group. 2. bacillus icteroides (sanarelli) is a member of the hog-cholera group. 3. the various channels of infection, the duration of the disease and the gross and microscopical lesions in mice, guinea-pigs and rabbits are the same for bacillus icteroides and the hog-cholera bacillus. 4. the clinical symptoms and the lesions observed in dogs inoculated intravenously with bacillus icteroides, are reproduced in these animals by infection with the hog- ...190019866945
abnormal kidneys from the domestic pig (sus scrofa). 189417232112
transmission routes of african swine fever virus to domestic pigs: current knowledge and future research directions.african swine fever (asf) is a major threat to the pig industry in europe. since 2007, asf outbreaks have been ongoing in the caucasus, eastern europe and the baltic countries, causing severe economic losses for many pig farmers and pork producers. in addition, the number of asf cases in wild boar populations has dramatically increased over the past few years. evidence supports direct contact with infectious domestic pigs and wild boars, and consumption of contaminated feed, as the main transmis ...026966305
an engineering approach to modelling, decision support and control for sustainable systems.engineering research and development contributes to the advance of sustainable agriculture both through innovative methods to manage and control processes, and through quantitative understanding of the operation of practical agricultural systems using decision models. this paper describes how an engineering approach, drawing on mathematical models of systems and processes, contributes new methods that support decision making at all levels from strategy and planning to tactics and real-time contr ...017656345
discrimination of infant isolation calls by female greater spear-nosed bats, phyllostomus hastatus.in colonial species, recognition of offspring should be under strong selection. for accurate identification to occur offspring must emit individually distinctive signals and parents must be able to discriminate between signals. female greater spear-nosed bats (phyllostomus hastatus) roost in stable social groups and use infant vocalizations, termed isolation calls, to locate and identify their young. in this study, we investigate both the production and perception of isolation calls in p. hastat ...018311319
edema and tetraparesis in a miniature pig after allogeneic hematopoietic cell transplantation.a 3-mo-old, 12-kg, intact, miniature pig presented with severe neurologic signs on day 8 after hematopoietic cell transplantation. this pig had received an immunosuppressive regimen before transplantation that included an anticd3 immunotoxin for t-cell depletion, 100 cgy of total-body irradiation, and cyclosporine for 45 d. the pig began exhibiting erythematous lesions on posttransplantation day 7. he also demonstrated increased conscious proprioceptive deficits and recumbency but normal mentati ...023043783
differential limb loading in miniature pigs (sus scrofa domesticus): a test of chondral modeling theory.variation in mechanical loading is known to influence chondrogenesis during joint formation. however, the interaction among chondrocyte behavior and variation in activity patterns is incompletely understood, hindering our knowledge of limb ontogeny and function. here, the role of endurance exercise in the development of articular and physeal cartilage in the humeral head was examined in 14 miniature swine (sus scrofa domesticus). one group was subjected to graded treadmill running over a period ...022496283
genetic architecture of body size in mammals.much of the heritability for human stature is caused by mutations of small-to-medium effect. this is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.022546202
use of ¹⁸f-fluorodeoxyglucose positron emission tomography-computed tomography in a miniature pig (sus scrofa domestica) with pneumonia.a 1-y-old male miniature pig housed in our laboratory facility was evaluated for weight loss and rough coat condition. cbc results revealed neutrophilia. radiography of the thoracic area showed increased opacity throughout the thoracic cavity except for the right caudal lobe. ¹⁸f-labeled fluorodeoxyglucose positron emission tomography-computed tomography (fdg-pet-ct) revealed elevated standard uptake values in the area corresponding to the radiologic findings. follow-up thoracic radiography take ...022776053
characterization and repeat analysis of the compact genome of the freshwater pufferfish tetraodon nigroviridis.tetraodon nigroviridis is a freshwater pufferfish 20-30 million years distant from fugu rubripes. the genome of both tetraodontiforms is compact, mostly because intergenic and intronic sequences are reduced in size compared to other vertebrate genomes. the previously uncharacterized tetraodon genome is described here together with a detailed analysis of its repeat content and organization. we report the sequencing of 46 megabases of bacterial artificial chromosome (bac) end sequences, which repr ...010899143
centromeric heterochromation exchange by an autosomal reciprocal 1/16 translocation in the pig (sus scrofa domestica). 022896238
identification of the x chromosome of the domestic pig (sus scrofa domestica). 022896166
[not available]. 022896144
identification of the chromosomes of the domestic pig (sus scrofa domestica). an identification key and a landmark system. 022896553
quantitative pcr method for sensitive detection of ruminant fecal pollution in freshwater and evaluation of this method in alpine karstic regions.a quantitative taqman minor-groove binder real-time pcr assay was developed for the sensitive detection of a ruminant-specific genetic marker in fecal members of the phylum bacteroidetes. the qualitative and quantitative detection limits determined were 6 and 20 marker copies per pcr, respectively. tested ruminant feces contained an average of 4.1 x 10(9) marker equivalents per g, allowing the detection of 1.7 ng of feces per filter in fecal suspensions. the marker was detected in water samples ...016885315
segmented filamentous bacteria: commensal microbes with potential effects on research.segmented filamentous bacteria (sfb) are commensal bacteria that were first identified in the ilea of mice and rats. morphologically similar bacteria occur in a broad range of host species, but all strains have been refractory to in vitro culture thus far. although sfb were once considered innocuous members of the intestinal microbiota of laboratory rodents, they are now known to affect the development of the immune system in rodents and, subsequently, the phenotype of models of both enteric and ...024674582
surgical porcine myocardial infarction model through permanent coronary occlusion.using domestic pigs as an animal model, we here validated a reproducible and standardized myocardial infarction (mi) surgical model, to achieve the largest possible infarct extent with the lowest morbidity and mortality. to this end, we included several anesthetic and perisurgical precautions to minimize surgical complications. mortality and morbidity rates were compared among groups of pigs that underwent permanent occlusion at different locations of either the left circumflex or left anterior ...022330353
analyses of pig genomes provide insight into porcine demography and evolution.for 10,000 years pigs and humans have shared a close and complex relationship. from domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. here we present the assembly and analysis of the genome sequence of a female domestic duroc pig (sus scrofa) and a comparison with the genomes of wild and domestic pigs from europe and asia. wild pigs emerged in south east asia and subsequently spread across eurasia. our results reveal a deep phylogenetic split between eu ...023151582
porcine salivary analysis by 2-dimensional gel electrophoresis in 3 models of acute stress: a pilot study.the purpose of this research was to study changes in the salivary proteome of healthy pigs in stressful situations to identify any potential new salivary biomarker of stress. three groups of animals were subjected to 3 stress models: snaring restraint followed by simulated sampling of vena cava blood; brief transport by road; and restriction of movement in a digestibility cage. saliva was obtained from each animal before and 15 and 30 min after the induction of stress. the samples from the anima ...024688174
domestication and the mitochondrial genome: comparing patterns and rates of molecular evolution in domesticated mammals and birds and their wild relatives.studies of domesticated animals have led to the suggestion that domestication could have significant effects on patterns of molecular evolution. in particular, analyses of mitochondrial genome sequences from domestic dogs and yaks have yielded higher ratios of non-synonymous to synonymous substitutions in the domesticated lineages than in their wild relatives. these results are important because they imply that changes to selection or population size operating over a short timescale can cause si ...024459286
substantial variation in the extent of mitochondrial genome fragmentation among blood-sucking lice of mammals.blood-sucking lice of humans have extensively fragmented mitochondrial (mt) genomes. human head louse and body louse have their 37 mt genes on 20 minichromosomes. in human pubic louse, the 34 mt genes known are on 14 minichromosomes. to understand the process of mt genome fragmentation in the blood-sucking lice of mammals, we sequenced the mt genomes of the domestic pig louse, haematopinus suis, and the wild pig louse, h. apri, which diverged from human lice approximately 65 ma. the 37 mt genes ...023781098
laparoscopic anterior resection: new anastomosis technique in a pig model.bowel anastomosis after anterior resection is one of the most difficult tasks to perform during laparoscopic colorectal surgery. this study aims to evaluate a new feasible and safe intracorporeal anastomosis technique after laparoscopic left-sided colon or rectum resection in a pig model.025392669
community dynamics of carrion flies and their parasitoids in experimental carcasses in central argentina.insects are the predominant group regarding both species richness and abundance that develop on carrion. among them, the most important decomposers using carrion as a source of food for their development are the immature stages of the dipteran families calliphoridae, muscidae, and sarcophagidae. the large numbers of their larvae in carcasses are attacked by a rich community of parasitoids, including species of braconidae, ichneumonidae, and pteromalidae (hymenoptera: parasitica). the objective o ...022963038
effects of various anesthetic protocols on 18f-flurodeoxyglucose uptake into the brains and hearts of normal miniature pigs (sus scrofa domestica).this study used positron emission tomography-computed tomography (pet-ct) to evaluate the effects of 4 anesthetic protocols on 2-deoxy-2-[18f]-fluoro-d-glucose (18f-fdg) accumulation in the brains and hearts of miniature pigs (sus scrofa domestica). the 18f-fdg standard uptake value was quantified by dividing the brain into 6 regions: cerebellum, brainstem, and frontal, parietal, temporal, and occipital lobes. five (2 female and 3 male) clinically normal miniature pigs were premedicated with med ...022776126
house infestation dynamics and feeding sources of triatoma dimidiata in central veracruz, mexico.chagas disease is endemic in the state of veracruz, mexico, and we investigated here the dynamics of house infestation by chagas disease vectors to understand disease transmission and design effective control interventions. bug collections in 42 rural villages confirmed the widespread distribution of triatoma dimidiata in central veracruz. unexpectedly, collection data further indicated a clear pattern of seasonal infestation by mostly adult bugs. analysis of feeding sources with a polymerase ch ...022492153
assessment of postoperative analgesia after application of ultrasound-guided regional anesthesia for surgery in a swine femoral fracture model.management of pain in research swine used for studies involving painful procedures is a considerable challenge. here we assessed whether a regional anesthesia method is effective for pain control of hindlimb injuries in pigs used for research in bone fracture healing. for this randomized controlled study, we administered regional anesthesia before an experimental femoral injury was produced. using ultrasound guidance, we placed sterile infusion catheters near the sciatic and femoral nerves and a ...023849409
mood and personality interact to determine cognitive biases in pigs.cognitive bias has become a popular way to access non-human animal mood, though inconsistent results have been found. in humans, mood and personality interact to determine cognitive bias, but to date, this has not been investigated in non-human animals. here, we demonstrate for the first time, to the best of our knowledge, in a non-human animal, the domestic pig (sus scrofa domesticus), that mood and personality interact, impacting on judgement. pigs with a more proactive personality were more l ...027852940
new polymorphism of the influenza virus resistance mx1 gene in iberian domestic pigs.mx1 (myxovirus (influenza virus) resistance 1, interferon-inducible protein p78) gene has been implicated in the resistance to a wide range of rna viruses including influenza a in several species such as sus scrofa. in the present study a 28-bp deletion in exon 14 of the mx1 gene has been identified in iberian domestic pigs but not in other domestic breeds neither in wild boars. the mutation produces a frameshift giving a protein with 6 amino acid substitutions and the extension of the c-termina ...027774491
endoscopic ultrasonography-guided placement of a transhepatic portal vein stent in a live porcine model.percutaneous portal vein (pv) stent placement is used to manage pv occlusion or stenosis caused by malignancy. the use of endoscopic ultrasonography (eus) has expanded to include vascular interventions. the aim of this study was to examine the technical feasibility and safety of eus-guided transhepatic pv stent placement in a live porcine model.027803904
anomalous right coronary artery originating from the left sinus of valsalva in a yucatan minipig.a 39.2-kg, castrated male yucatan minipig (sus scrofa domestica) was presented for enrollment in a coronary artery study. angiography revealed an anomalous right coronary artery originating from the left sinus of valsalva. the left anterior descending, left circumflex, and anomalous right coronary arteries were implanted with metallic stents without complications. the minipig remained on the study for 3 mo until it reached its predetermined study endpoint, during which time it showed no clinical ...022546919
unravelling the complexity of domestication: a case study using morphometrics and ancient dna analyses of archaeological pigs from romania.current evidence suggests that pigs were first domesticated in eastern anatolia during the ninth millennium cal bc before dispersing into europe with early neolithic farmers from the beginning of the seventh millennium. recent ancient dna (adna) research also indicates the incorporation of european wild boar into domestic stock during the neolithization process. in order to establish the timing of the arrival of domestic pigs into europe, and to test hypotheses regarding the role european wild b ...025487340
novel technique for retroperitoneal implantation of telemetry transmitters for physiologic monitoring in göttingen minipigs (sus scrofa domesticus).telemetric monitoring of physiologic parameters in animal models is a critical component of chemical and biologic agent studies. the long-term collection of neurobehavioral and other physiologic data can require larger telemetry devices. furthermore, such devices must be implanted in a location that is safe, well-tolerated, and functional. göttingen minipigs (sus scrofa domesticus) present an ideal large animal model for chemical agent studies due to their relatively small size, characterized he ...025527027
blood-banking techniques for plateletpheresis in swine.during the past several years, trauma resuscitation in human patients has evolved from decreased use of crystalloids to increased use of blood products. of high interest is the role of platelets in trauma resuscitation. because conducting prehos- pital resuscitation in human trauma patients is very difficult, swine are often the animal model of choice for such studies because their coagulation and hemodynamic systems are similar to those in humans. however, consistent production of sufficient sw ...024827574
therapeutic uses of animal biles in traditional chinese medicine: an ethnopharmacological, biophysical chemical and medicinal review.forty-four different animal biles obtained from both invertebrates and vertebrates (including human bile) have been used for centuries for a host of maladies in traditional chinese medicine (tcm) beginning with dog, ox and common carp biles approximately in the zhou dynasty (c. 1046-256 bce). overall, different animal biles were prescribed principally for the treatment of liver, biliary, skin (including burns), gynecological and heart diseases, as well as diseases of the eyes, ears, nose, mouth ...025110425
a comparative anatomic and physiologic overview of the porcine heart.despite advances during the last 2 decades in every aspect of cardiovascular research (interventional cardiology, cardiopulmonary resuscitation, and so forth), western societies still are plagued by the consequences of cardiovascular disease. consequently the discovery of new regimens and therapeutic interventions is of utmost importance. research using human subjects is associated with substantial methodologic and ethical considerations, and the quest for an appropriate animal model for the hum ...025255064
assessment of gel-coated delayed self-gripping mesh.mesh hernia repair is one of the most frequently performed procedures in general surgery. recently, use of the self-gripping mesh demonstrated a beneficial effect on postoperative pain in inguinal hernia repairs. however, in intra-abdominal placement, the use of this novel mesh requires greater laparoscopic skill and dexterity because of the mesh's tendency to fold and adhere to itself and to any surrounding tissues. we hypothesized that gel-like coverage of a self-gripping mesh with a water-sol ...025516704
pharmacokinetics of sustained-release and transdermal buprenorphine in göttingen minipigs (sus scrofa domestica).the opioid buprenorphine has been shown to provide adequate postoperative analgesia in both companion and laboratory animals. however, its use is still hindered by the need for multiple parenteral injections to achieve continuous analgesia. the purpose of the current study was to conduct a pharmacokinetic analysis of 2 new long-acting formulations of buprenorphine-an injectable sustained-release buprenorphine (srb) and a transdermal buprenorphine (tdb) patch-in healthy göttingen minipigs by usin ...025650977
evaluation of genome based estimated breeding values for meat quality in a berkshire population using high density single nucleotide polymorphism chips.the accuracy of genomic estimated breeding values (gebv) was evaluated for sixteen meat quality traits in a berkshire population (n = 1,191) that was collected from dasan breeding farm, namwon, korea. the animals were genotyped with the illumina porcine 62 k single nucleotide polymorphism (snp) bead chips, in which a set of 36,605 snps were available after quality control tests. two methods were applied to evaluate gebv accuracies, i.e. genome based linear unbiased prediction method (gblup) and ...025358312
a mathematical analysis of obstructed diffusion within skeletal muscle.molecules are transported through the myofilament lattice of skeletal muscle fibers during muscle activation. the myofilaments, along with the myosin heads, sarcoplasmic reticulum, t-tubules, and mitochondria, obstruct the diffusion of molecules through the muscle fiber. in this work, we studied the process of obstructed diffusion within the myofilament lattice using monte carlo simulation, level-set and homogenization theory. we found that these intracellular obstacles significantly reduce the ...019527637
the community of hymenoptera parasitizing necrophagous diptera in an urban biotope.most reports published in the field of forensic entomology are focused on diptera and neglect the hymenoptera community. however, hymenoptera are part of the entomofaunal colonization of a dead body. the use of hymenoptera parasitoids in forensic entomology can be relevant to evaluate the time of death. hymenoptera parasitoids of the larvae and pupae of flies may play an important role in the estimation of the post-mortem period because their time of attack is often restricted to a small, well-d ...023895458
soybean yield and heterodera glycines responses to liquid swine manure in nematode suppressive soil and conducive soil.the soybean cyst nematode (scn), heterodera glycines, is a major factor limiting soybean yield. experiments were conducted in 2009 and 2010 to determine the effects of liquid swine manure and chemical fertilizer pk on soybean and corn yields, and on scn population in an scn-suppressive field (s-site) and an scn-conducive field (c-site) in minnesota. the experiment was a split-plot design with crop sequences as main plots and fertilizer treatments as subplots. the 2-yr crop sequences were sus-sus ...023589656
exposure of feral swine (sus scrofa) in the united states to selected pathogens.feral swine (sus scrofa) are widely distributed in the united states. in 2011 and 2012, serum samples and tonsils were recovered from 162 and 37 feral swine, respectively, in the us to evaluate exposure to important swine endemic pathogens. antibodies against porcine reproductive and respiratory syndrome virus (prrsv) and porcine circovirus type 2 (pcv2) were found in 2.5% and 25.3% of tested sera, respectively. positive serological reactions against mycoplasma hyopneumoniae and actinobacillus p ...025673913
tamoxifen decreases the myofibroblast count in the healing bile duct tissue of pigs.the aim of this study was to evaluate the effect of oral tamoxifen treatment on the number of myofibroblasts present during the healing process after experimental bile duct injury.023420165
validation of respiratory inductance plethysmography for measuring tidal volume in swine.measuring tidal volume (vt) in nonintubated swine or swine with leaking breathing circuits is challenging. the aim of this study was to validate respiratory inductance plethysmography (rip) for measuring vt in swine that are comparable in size to adult humans. to determine calibration curves, vt and rip readings were obtained from anesthetized swine (n = 8; weight, 46-50 kg) during positive-pressure (mechanical) ventilation and spontaneous breathing. for positive-pressure ventilation, 6 pigs wer ...026141447
optical coherence tomography of pulmonary arterial walls in humans and pigs (sus scrofa domesticus).pulmonary arterial hypertension (pah) is a devastating disorder characterized by progressive elevation of the pulmonary pressures that, in the absence of therapy, results in chronic right-heart failure and premature death. the vascular pathology of pah is characterized by progressive loss of small (diameter, less than 50 μm) peripheral pulmonary arteries along with abnormal medial thickening, neointimal formation, and intraluminal narrowing of the remaining pulmonary arteries. vascular pathology ...026141446
acute inflammatory response to transgastric natural orifice transluminal endoscopic surgery peritoneoscopy: an experimental study in swine.to investigate the impact of transgastric peritoneal access on plasma biomarkers of acute inflammatory response in comparison to laparoscopy.024270956
gastric endoscopic submucosal dissection: from animal model to patient.to assess whether the use of porcine models is useful for learning endoscopic submucosal dissection (esd), thus contributing to its subsequent application in human patients.024363524
effects of mobilization regimens in donors on outcomes of hematopoietic cell transplantation in miniature swine.toxicities and complications associated with hematopoietic cell transplantation currently limit this potentially curative therapy for malignant and nonmalignant blood disorders. miniature swine provide a clinically relevant model for studies to improve posttransplantation outcomes. miniature swine recipients of high-dose haploidentical hepatopoietic cell transplantation after reduced-intensity conditioning consisting of low-dose (100 cgy) total-body irradiation, partial t-cell depletion by using ...023561882
no evidence of gouléako and herbert virus infections in pigs, côte d'ivoire and ghana.a recent report suggested that 2 novel bunyaviruses discovered in insects in côte d'ivoire caused lethal disease in swine in south korea. we conducted cell culture studies and tested serum from pigs exposed to mosquitoes in côte d'ivoire and ghana and found no evidence for infection in pigs.026583956
one health, multiple challenges: the inter-species transmission of influenza a virus.influenza a viruses are amongst the most challenging viruses that threaten both human and animal health. influenza a viruses are unique in many ways. firstly, they are unique in the diversity of host species that they infect. this includes waterfowl (the original reservoir), terrestrial and aquatic poultry, swine, humans, horses, dog, cats, whales, seals and several other mammalian species. secondly, they are unique in their capacity to evolve and adapt, following crossing the species barrier, i ...026309905
evidence for litter differences in play behaviour in pre-weaned pigs.the aim of this study was to analyse spontaneous play behaviour in litters of domestic pigs (sus scrofa) for sources of variation at individual and litter levels and to relate variation in play to measures of pre and postnatal development. seven litters of commercially bred piglets (n = 70) were born (farrowed) within a penning system (pigsafe) that provided opportunities for the performance of spontaneous play behaviours. individual behaviour was scored based on an established play ethogram for ...026937060
miniature swine as a clinically relevant model of graft-versus-host disease.miniature swine provide a preclinical model of hematopoietic cell transplantation (hct) for studies of graft-versus-host disease. hct between mhc-matched or -mismatched pigs can be performed to mimic clinical scenarios with outcomes that closely resemble those observed in human hct recipients. with myeloablative conditioning, hct across mhc barriers is typically fatal, with pigs developing severe (grade iii or iv) gvhd involving the gastrointestinal tract, liver, and skin. unlike rodent models, ...026473348
denosumab could be a potential inhibitor of valvular interstitial cells calcification in vitro.denosumab is a fully human monoclonal antibody and novel antiresorptive agent that works by binding receptor activator of nuclear factor kappa-β ligand (rankl) and inhibiting the signaling cascade that causes osteoclast maturation, activity, and survival. we aimed to elucidate the effect of denosumab in the process of spontaneous and induced calcification in an in vitro porcine valvular interstitial cells (vics) model.027468412
using na3po4 to enhance in vitro animal models of aortic valve calcification.the pathogenesis of calcific aortic valvular disease (cavd) involves an active inflammatory process of valvular interstitial cells (vics) characterized by the activation of specific osteogenic signaling pathways and apoptosis. this process can be studied by analyzing certain molecular markers and gene expression pathways of spontaneous calcification. the purpose of our study is to investigate the role of sodium phosphate (na3po4) as a calcification promoter, with the aim of improving in vitro an ...027376093
use of domesticated pigs by mesolithic hunter-gatherers in northwestern europe.mesolithic populations throughout europe used diverse resource exploitation strategies that focused heavily on collecting and hunting wild prey. between 5500 and 4200 cal bc, agriculturalists migrated into northwestern europe bringing a suite of neolithic technologies including domesticated animals. here we investigate to what extent mesolithic ertebølle communities in northern germany had access to domestic pigs, possibly through contact with neighbouring neolithic agricultural groups. we emplo ...023982268
pancreatic islet plasticity: interspecies comparison of islet architecture and composition.the pancreatic islet displays diverse patterns of endocrine cell arrangement. the prototypic islet, with insulin-secreting beta-cells forming the core surrounded by other endocrine cells in the periphery, is largely based on studies of normal rodent islets. recent reports on large animals, including humans, show a difference in islet architecture, in which the endocrine cells are randomly distributed throughout the islet. this particular species difference has raised concerns regarding the inter ...020657742
evolution and spectral tuning of visual pigments in birds and mammals.variation in the types and spectral characteristics of visual pigments is a common mechanism for the adaptation of the vertebrate visual system to prevailing light conditions. the extent of this diversity in mammals and birds is discussed in detail in this review, alongside an in-depth consideration of the molecular changes involved. in mammals, a nocturnal stage in early evolution is thought to underlie the reduction in the number of classes of cone visual pigment genes from four to only two, w ...019720655
the pig peptideatlas: a resource for systems biology in animal production and biomedicine.biological research of sus scrofa, the domestic pig, is of immediate relevance for food production sciences, and for developing pig as a model organism for human biomedical research. publicly available data repositories play a fundamental role for all biological sciences, and protein data repositories are in particular essential for the successful development of new proteomic methods. cumulative proteome data repositories, including the peptideatlas, provide the means for targeted proteomics, sy ...026699206
analysis of gene expression and ultrastructure of stifle menisci from juvenile and adult pigs.the origin of the age-associated degenerative processes in meniscal tissue is poorly understood and may be related to an imbalance of anabolic and catabolic metabolism. the aim of the current study was to compare medial menisci isolated from juvenile pigs and degenerated medial menisci from adult pigs in terms of gene expression profile and ultrastructure. medial menisci were isolated from the knee joints of juvenile and adult pigs (n = 8 for each group). degeneration was determined histological ...026884408
electron probe x-ray microanalysis of boar and inobuta testes after the fukushima accident.we aimed to investigate the effect of chronic radiation exposure associated with the fukushima daiichi nuclear power plant (fnpp) accident on the testes of boar and inobuta (a hybrid of sus scrofa and sus scrofa domestica). this study examined the contamination levels of radioactive caesium (cs), especially (134)cs and (137)cs, in the testis of both boar and inobuta during 2012, after the fukushima accident. morphological analysis and electron-probe x-ray microanalysis (epma) were also undertake ...026825300
normal electrocardiogram of bama miniature pigs (sus scrofa domestica).this study determined the normal ecg patterns and values for bama miniature pigs. standard limb-lead ecg were recorded from 120 clinically healthy, unanesthetized piglets (age, 2 to 4 mo). the values for the ecg parameters (mean ± 1 sd) were: heart rate, 125.56 ± 18.80 bpm; p amplitude, 0.11 ± 0.03 mv; qrs amplitude, 0.63 ± 0.31 mv; p duration, 43.99 ± 5.98 ms; qrs complex, 55.27 ± 7.02 ms; rr interval, 487.55 ± 77.32 ms; pr interval, 90.72 ± 11.94 ms; qt interval, 244.72 ± 25.27 ms; and mean el ...027025805
when is it socially acceptable to feel sick?disease is a ubiquitous and powerful evolutionary force. hosts have evolved behavioural and physiological responses to disease that are associated with increased survival. behavioural modifications, known as 'sickness behaviours', frequently involve symptoms such as lethargy, somnolence and anorexia. current research has demonstrated that the social environment is a potent modulator of these behaviours: when conflicting social opportunities arise, animals can decrease or entirely forgo experienc ...024943375
spontaneous dilated cardiomyopathy and right-sided heart failure as a differential diagnosis for hepatosis dietetica in a production pig.an experimentally naïve 37.7-kg yorkshire-crossbred gilt died unexpectedly 2 d after arrival. necropsy revealed severe dilated cardiomyopathy characterized grossly by markedly dilated ventricles and thinned ventricular walls and interventricular septum. histologically there was multifocal myofiber attenuation and patchy loss of myofiber cross striations. the liver contained submassive to massive, diffuse hepatic centrilobular hemorrhage and degeneration. these lesions supported a diagnosis of di ...026310462
disease risks associated with free-ranging wild boar in saskatchewan.this study investigated the disease status of saskatchewan's feral wild boar population. whole carcasses, tissue samples, and/or serum from 81 hunter-killed boars from saskatchewan were submitted to the canadian wildlife health cooperative (cwhc) between 2009 and 2014. serological tests were negative for prrs, h1n1, and h3n2 swine influenza, pcv-2, and tge/prcv in 22/22 boars and for toxoplasma gondii and mycoplasma hyopneumoniae in 20/20 boars. of 20 boars whose sera were tested 20 were positiv ...026246630
pharmacokinetics of ceftiofur crystalline free acid in male rhesus macaques (macaca mulatta) after subcutaneous administration.trauma is a common sequela to agonistic social encounters in rhesus macaques (macaca mulatta), and veterinarians often prescribe antibiotics as part of a balanced treatment plan. long-acting, single-dose, injectable antibiotics for use in rhesus macaques are unavailable currently. ceftiofur crystalline free acid (ccfa) is a long-acting, single-dose, injectable third-generation cephalosporin that provides at least 7 d of ceftiofur therapeutic plasma concentrations in swine (sus scrofa domesticus) ...026424255
comparison of heart rate and blood pressure with toe pinch and bispectral index for monitoring the depth of anesthesia in piglets.determining depth of anesthesia (doa) is a clinical challenge in veterinary medicine, yet it is critical for the appropriate oversight of animals involved in potentially painful experimental procedures. here, we investigated various parameters used to monitor conscious awareness during surgical procedures and refined the application of noxious stimuli to anesthetized animals. specifically we used a common stimulus, a compressive toe pinch (tp), to determine physiologic changes that accompanied a ...026424252
improved bleeding scores using gelfoam(®) powder with incremental concentrations of bovine thrombin in a swine liver lesion model.topical hemostatic agents are used intra-operatively to prevent uncontrolled bleeding. gelfoam(®) powder contains a hemostatic agent prepared from purified pork skin gelatin, the efficacy of which is increased when combined with thrombin. however, the effect of increasing concentrations of thrombin on resultant hemostasis is not known. this study sought to evaluate the ability of various concentrations of thrombin in combination with gelfoam powder to control bleeding using a swine liver lesion ...027334382
efficacy and safety of a new single-port model for appendectomy: experimental study on swine.with the cooperation of surgeons and the engineering division of the company bhio supply(©) (esteio-rs, brazil), a permanent single port was developed.027073304
tissue repair genes: the tire database and its implication for skin wound healing.wound healing is an inherent feature of any multicellular organism and recent years have brought about a huge amount of data regarding regular and abnormal tissue repair. despite the accumulated knowledge, modulation of wound healing is still a major biomedical challenge, especially in advanced ages. in order to collect and systematically organize what we know about the key players in wound healing, we created the tire (tissue repair) database, an online collection of genes and proteins that wer ...027049721
radiographic morphometry of the lumbar spine in munich miniature pigs.the incidence of human spinal column disease remains high, and animal models still play important roles in prophylactic, diagnostic, and therapeutic research. because of their similar size to humans, pigs remain an important spine model. for pigs to serve as a model for the human spine, basic similarities and differences must be understood. in this study, morphometric data of the lumbar spine of munich miniature pigs (troll) were recorded radiologically, evaluated, and compared with recorded hum ...027177570
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